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Perioperative Management of Patients with Undergoing Mechanical Circulatory Support

In conclusion this special edition focuses the attention of the reader on the next step up for mechanical circulatory support. The excellent survival records move towards reducing complications for even better outcomes. We thank the authors who have vast experience in their field and believe these review articles to be not only discussion of published literature but also be seen through the eyes of the practicing doctor. We hope they will be interesting for many specialities medics and allied professionals who are working with patients in advanced heart failure supported by machines.

Hemodynamic Monitoring in Critically Ill Patients

This series of Annals of Translational Medicine presents a collection of review articles on hemodynamic monitoring in the critically ill patient. The limits and scopes of hemodynamic monitoring has broadened over the last decades with the incorporation of new less invasive techniques such as bedside point-of-care echocardiography. On the other hand, resuscitation concepts have changed and moved from a cardiac output centered approach to perfusion-driven strategies.

Tumor Associated Macrophages in Solid Tumor: Friend or Foe

The focused series aims to highlight the current status of TAMs research in context to solid tumors in a preclinical and clinical setting. We have invited distinguished scientists from the different onco- immunology field for this focused series. I hope, the reviews will help the reader to understand in detail macrophages topographical and temporal heterogeneity and functional diversity in different tumor types.

New Impact Factor for Annals of Translational Medicine: 3.297

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2019 citation year: 3.297.

Here, we would like to extend our heartfelt gratitude to all our Editorial Team Members, Guest Editors, authors, and reviewers for their significant contributions. We look forward to the continuous cooperation with all the individuals mentioned above and those who are interested in translational medicine to bring more exciting content to readers in the coming future. Read More>>

Cancer Metastasis: Molecular signaling and therapeutic options

As guest editor of this special series of the Annals of Translational Medicine (ATM), I would like to share with the readers at large the contributions from invited authors who provided their unique and expert perspectives on the important and critical topics of this focus series titled “Cancer Metastasis: Molecular signaling and therapeutic options”.

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others), as of April 2020. Around 60 AME journals’ peer review systems are now integrated seamlessly into the Publons platform (https://publons.com/about/home). The partnership was done to recognize our expert peer reviewers spontaneously for their review contribution.

Implementation of transparent peer review at Annals of Translational Medicine

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a transparent peer review process as an option for all manuscripts submitted to ATM from March 19, 2020.

ATM Annual Report 2019

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2020. 2019 has seen much progress for the journal:
- The first Impact Factor for ATM: 3.689
- More than 1000 papers have been published in ATM in 2019
- The retrieval of ATM in PubMed increased rapidly with a total of 2, 372, 977 times in 2019.
- The number of total citations by SCI journals has significantly increased to 11,592 until Dec. 2019
- The pageviews of ATM is increasing significantly, with a total of 1,034,942 hits in 2019.

Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions

Background: The coronavirus disease 2019 (COVID-19) outbreak originating in Wuhan, Hubei province, China, coincided with chunyun, the period of mass migration for the annual Spring Festival. To contain its spread, China adopted unprecedented nationwide interventions on January 23, 2020. These policies included large-scale quarantine, strict controls on travel and extensive monitoring of suspected cases. However, it is unknown whether these policies have had an impact on the epidemic. We sought to show how these control measures impacted the containment of the epidemic.

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Vol 8, No 17 (September, 2020)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Foxk1 regulates cancer progression

Daniel J. Garry, Geunho Maeng, Mary G. Garry

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Limitations of the Barcelona clinic liver cancer staging treatment strategy in hepatocellular carcinoma patients with performance status 1

Jung Hwan Yu, Jin-Woo Lee

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The interplay between miR-1245a and BRCA2 in colorectal cancer

Andreas Scorilas, Konstantina Panoutsopoulou, Panagiotis Tsiakanikas

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Child Pugh and ALBI grade: past, present or future?

Margherita Rimini, Giulia Rovesti, Andrea Casadei-Gardini

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Changes in prognostic factors for patients with hepatocellular carcinoma underwent transarterial chemoembolization with the transition of the time: Child-Pugh class, Albumin-Bilirubin grade, and then

Takumi Kawaguchi, Shigeo Shimose, Sakura Yamamura, Dan Nakano, Masatoshi Tanaka, Takuji Torimura

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Original Article

Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12-CXCR4/7 axis in bone marrow microenvironment

Hanbo Cao, Yuan Gao, Ruixuan Wang, Qinglong Guo, Hui Hui

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Apatinib as first-line treatment in patients with advanced hepatocellular carcinoma: a phase II clinical trial

Zhenyu Hou, Keyun Zhu, Xuejiao Yang, Ping Chen, Wei Zhang, Yunlong Cui, Xiaolin Zhu, Tianqiang Song, Qiang Li, Huikai Li, Ti Zhang

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Efficacy and safety of CD19 chimeric antigen receptor T cells in the treatment of 11 patients with relapsed/refractory B-cell lymphoma: a single-center study

Chen Huang, Lili Wu, Ruixia Liu, Weijing Li, Zheng Li, Jianqiang Li, Lihong Liu, Baoen Shan

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Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predict in vitro fertilization and embryo transfer outcomes

Qian Yi, Chao Meng, Ling-Bo Cai, Yu-Gui Cui, Jia-Yin Liu, Yan Meng

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Identification of molecular features correlating with tumor immunity in gastric cancer by multi-omics data analysis

Yin He, Xiaosheng Wang

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Differential expression of genes related to calcineurin and mTOR signaling and regulatory miRNAs in peripheral blood from kidney recipients under tacrolimus-based therapy

Vivian Bonezi, Fabiana Dalla Vecchia Genvigir, Patrícia de Cássia Salgado, Claudia Rosso Felipe, Helio Tedesco-Silva Jr, José Osmar Medina-Pestana, Alvaro Cerda, Sonia Quateli Doi, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata

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Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer

Xiangmei Zhang, Jingping Li, Qing Yang, Yanfang Wang, Xinhui Li, Yunjiang Liu, Baoen Shan

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Clinical features and mortality-related factors of extensive burns among young adults: the Kunshan disaster experience

Ying-Zi Huang, Guo-Zhong Lu, Hong-Sheng Zhao, Li-Jun Liu, Jun Jin, Yun-Fu Wu, Jian Wu, Fu-Li Zhao, Ning Liu, Wen-Ming Liu, Long Liu, Tuan-Jie Zhu, Er-Zhen Chen, Qin Gu, Hong-Wei Ye, Xiu-Ming Xi, Bin Du, Yang Yi, Hai-Bo Qiu

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Bioabsorbable high-purity magnesium interbody cage: degradation, interbody fusion, and biocompatibility from a goat cervical spine model

Xiuwu Guo, Haocheng Xu, Fan Zhang, Feizhou Lu

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Repeated radioembolization in advanced liver cancer

Max Masthoff, Philipp Schindler, Fabian Harders, Walter Heindel, Christian Wilms, Hartmut H. Schmidt, Andreas Pascher, Lars Stegger, Kambiz Rahbar, Moritz Wildgruber, Michael Köhler

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Shifting workstyle to teleworking as a new normal in face of COVID-19: analysis with the model introducing intercity movement and behavioral pattern

Kenji Karako, Peipei Song, Yu Chen, Wei Tang

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Blocking the Notch signal transduction pathway promotes tumor growth in osteosarcoma by affecting polarization of TAM to M2 phenotype

Shuguang Ren, Xiangmei Zhang, Yueyang Hu, Jianhua Wu, Yingchao Ju, Xu Sun, Yunjiang Liu, Baoen Shan

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A pilot study of expanded newborn screening for 573 genes related to severe inherited disorders in China: results from 1,127 newborns

Xiaomei Luo, Yu Sun, Feng Xu, Jun Guo, Lin Li, Zhiwei Lin, Jun Ye, Xuefan Gu, Yongguo Yu

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The impact of antibiotics on the metabolic status of obese adults without bacterial infection: a systematic review and meta-analysis

Naofumi Yoshida, Yoshihiro Saito, Yasushi Tsujimoto, Shunsuke Taito, Masahiro Banno, Yuki Kataoka, Tomoya Yamashita, Ken-ichi Hirata

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Genetic polymorphisms in neuroendocrine disorder-related candidate genes associated with pre-pregnancy obesity in gestational diabetes mellitus patients by using a stratification approach

Kai Wei Lee, Siew Mooi Ching, Navin Kumar Devaraj, Fan Kee Hoo

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Novel inflammation-based prognostic nomograms for individualized prediction in hepatocellular carcinoma after radical resection

Jianxing Zeng, Jinhua Zeng, Qionglan Wu, Kongying Lin, Jianyang Zeng, Pengfei Guo, Weiping Zhou, Jingfeng Liu

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Reconstruction of the ocular surface by autologous transplantation of rabbit adipose tissue-derived stem cells on amniotic membrane

Ting Qiu, Lei Cui, Jian-Jiang Xu, Jia-Xu Hong, Jun Xiang

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Regulation of the regeneration of intestinal stem cells after irradiation

Liping Liang, Lijun Shen, Guoxiang Fu, Ye Yao, Guichao Li, Yun Deng, Hui Zhang, Menglong Zhou, Wang Yang, Guoqiang Hua, Zhen Zhang

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Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma

Gehui Ni, Kai Wang, Yufei Zhou, Xiaodong Wu, Jiaqi Wang, Hongcai Shang, Lijun Wang, Xinli Li

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Diagnostic accuracy of metagenomic next-generation sequencing for active tuberculosis in clinical practice at a tertiary general hospital

Wenting Jin, Jue Pan, Qing Miao, Yuyan Ma, Yao Zhang, Yingnan Huang, Yumeng Yao, Yi Su, Qingqing Wang, Mengran Wang, Bing Li, Rong Bao, Xiaodong Gao, Honglong Wu, Bijie Hu

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The profiles of biopsy-proven renal tubulointerstitial lesions in patients with glomerular disease

Jin Dong, Yanqin Li, Shuling Yue, Xiaoting Liu, Long Wang, Mengqi Xiong, Guobao Wang, Sheng Nie, Xin Xu

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Analysis of preoperative circulating tumor cells for recurrence in patients with hepatocellular carcinoma after liver transplantation

Zhitao Chen, Xiaohong Lin, Chuanbao Chen, Yinghua Chen, Qiang Zhao, Linwei Wu, Dongping Wang, Yi Ma, Weiqiang Ju, Maogen Chen, Xiaoshun He

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Development and formulation of the classification criteria for osteoarthritis

Cibo Huang, Zhiyi Zhang, Yaolong Chen, Yue Zhang, Dan Xing, Like Zhao, Jianhao Lin, Yifang Mei, Hsiao-Yi Lin, Yi Zheng, Wei-Chung Tsai, Shengyun Liu, Quan Jiang, Yi Liu, Jinwei Chen, Zhizhong Ye, Min Chen, Yingjuan Chen, Cong-Qiu Chu, Ming Gao, Lan He, Jin Lin, Lijun Wu, Jianhua Xu, Pinting Yang, Xuewu Zhang, Qing Jiang, Guanghua Lei, Mengtao Li, Wanling Yang, Xin Gu, Yixin Zhou, Dongyi He, Wei Liu, Weiya Zhang, Changhai Ding, Xiaofeng Zeng, on behalf of the COACH Group

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Hearing dysfunction in patients with Neuro-Sjögren: a cross-sectional study

Tabea Seeliger, Lena Bönig, Torsten Witte, Thea Thiele, Anke Lesinski-Schiedat, Martin Stangel, Thomas Lenarz, Nils Christian Prenzler, Thomas Skripuletz

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A prospective randomized cohort study on 3D-printed artificial vertebral body in single-level anterior cervical corpectomy for cervical spondylotic myelopathy

Feng Wei, Nanfang Xu, Zihe Li, Hong Cai, Feifei Zhou, Jun Yang, Miao Yu, Xiaoguang Liu, Yu Sun, Ke Zhang, Shengfa Pan, Fengliang Wu, Zhongjun Liu

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The utilization of aerosol therapy in mechanical ventilation patients: a prospective multicenter observational cohort study and a review of the current evidence

Shan Lyu, Jie Li, Limin Yang, Xiaoliang Du, Xiaoyi Liu, Libo Chuan, Guoqiang Jing, Zhenyan Wang, Weiwei Shu, Chunjuan Ye, Qionglan Dong, Jun Duan, James B. Fink, Zhancheng Gao, Zongan Liang, on behalf of Respiratory Care Committee Society

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A comparison of the delivery of inhaled drugs by jet nebulizer and vibrating mesh nebulizer using dual-source dual-energy computed tomography in rabbits: a preliminary in vivo study

Qixing Wang, Yuhao Liu, Zhengfang Zhu, Jian Hu, Li Li, Sheng Wang

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Adequate tissue acquisition rate of peroral cholangioscopy-guided forceps biopsy

Takumi Onoyama, Yohei Takeda, Soichiro Kawata, Hiroki Kurumi, Hiroki Koda, Taro Yamashita, Wataru Hamamoto, Yuri Sakamoto, Kazuya Matsumoto, Hajime Isomoto

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Coronavirus disease 2019: MRI examination procedures and infection prevention and protection

Xiaoyong Shen, Jinwen Meng, Qidong Wang, Lingmei Ni, Zifeng Zhong, Shaohua Hu, Feng Chen

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Impact of examined lymph node count on staging and long-term survival of patients with node-negative stage III gastric cancer: a retrospective study using a Chinese multi-institutional registry with Surveillance, Epidemiology, and End Results (SEER) data validation

Nannan Zhang, Huihui Bai, Jingyu Deng, Wei Wang, Zhe Sun, Zhenning Wang, Huimian Xu, Zhiwei Zhou, Han Liang

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The influences of TGF-β1 upon the human adenocarcinoma cell of lung A549 and cellular immunity

Min-Jie Li, Xi Wang, Ying Chen, Guang-Jian Li, Guang-Qiang Zhao, Bing-Quan Xiang, Xue-Qiang Wei, Yu-Jie Lei, Yun-Chao Huang

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Analysis of 2019-nCoV receptor ACE2 expression in different tissues and its significance study

Tao Han, Jing Kang, Gao Li, Jing Ge, Jia Gu

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Prognostic nomogram on clinicopathologic features and serum indicators for advanced non-small cell lung cancer patients treated with anti-PD-1 inhibitors

Rong Chai, Yinxing Fan, Jiayi Zhao, Fan He, Jianong Li, Yiping Han

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A novel parametric method-based nomogram of left ventricular internal diameters in normal Chinese adults

Huayiyang Zou, Yonghong Yong, Jinan Zhang, Bin Zhou, Lingjuan Zan, Xinzheng Lu, Xiangqing Kong

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Association of circulating 25-Hydroxyvitamin D and its related genetic variations with hepatocellular carcinoma incidence and survival

Hui Liu, Xia Jiang, Qiaohua Qiao, Liying Chen, Koichi Matsuda, Guangyi Jiang, Tunan Yu, Yifan Wang, Hui Lin, Xiao Liang, Xiujun Cai

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Induced membrane technique combined with antibiotic-loaded calcium sulfate–calcium phosphate composite as bone graft expander for the treatment of large infected bone defects: preliminary results of 12 cases

Zihou Zhao, Guoliang Wang, Yong Zhang, Wen Luo, Shiyu Liu, Zhaohui Zeng, Yunyan Liu, Yong Zhou, Yunfei Zhang

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High mobility group box 2 modulates the progression of osteosarcoma and is related with poor prognosis

Shicong Yang, Ziyin Ye, Zhuo Wang, Liantang Wang

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Ultrasound features and the diagnostic strategy of subhepatic appendicitis

Dong Yu, Chenyao Gu, Shuchen Zhang, Hui Yang, Taotao Yao

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Clinical characteristics of recovered COVID-19 patients with re-detectable positive RNA test

Jianghong An, Xuejiao Liao, Tongyang Xiao, Shen Qian, Jing Yuan, Haocheng Ye, Furong Qi, Chengguang Shen, Lifei Wang, Yang Liu, Xiaoya Cheng, Na Li, Qingxian Cai, Fang Wang, Jun Chen, Guojun Li, Qiu’e Cai, Yingxia Liu, Yunfang Wang, Feng Zhang, Yang Fu, Qing He, Xiaohua Tan, Lei Liu, Zheng Zhang

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The relationship between KRAS gene mutation and intestinal flora in tumor tissues of colorectal cancer patients

Xinke Sui, Yan Chen, Baojun Liu, Lianyong Li, Xin Huang, Min Wang, Guodong Wang, Xiaopei Gao, Lu Zhang, Xinwei Bao, Dengfeng Yang, Xiaoying Wang, Changqing Zhong

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Lipoxin A4 protects rat skin flaps against ischemia-reperfusion injury through inhibiting cell apoptosis and inflammatory response induced by endoplasmic reticulum stress

Dawei Xin, Renfu Quan, Linru Zeng, Canda Xu, Yanghua Tang

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Investigation of hub genes involved in diabetic nephropathy using biological informatics methods

Zhanting Li, Jianxin Liu, Weiwei Wang, Yunchun Zhao, Dengfeng Yang, Xiaodong Geng

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Risk factors of postoperative nausea and vomiting after total hip arthroplasty or total knee arthroplasty: a retrospective study

Yingjie Wang, Qi Yang, Jin Lin, Wenwei Qian, Jin Jin, Peng Gao, Baozhong Zhang, Bin Feng, Xisheng Weng

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Xanthogranulomatous cholecystitis: experience in 100 cases

Lei Feng, Zhen You, Junhe Gou, Erwen Liao, Liping Chen

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Expressions and relationship of Krüppel-like factor 15 and endothelial nitric oxide synthase in experimental deep venous thrombosis

Xianguang Yang, Yaoyu Xiang, Fuke Wang, Guofeng Cai, Yanlin Li, Ling Zhong, Li Pu, Yang Yang, En Song

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Review Article

The emerging prospects of circular RNA in tumor immunity

Lingjiao Meng, Pingan Ding, Sihua Liu, Ziyi Li, Meixiang Sang, Baoen Shan

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Transfer RNA-derived small RNAs: potential applications as novel biomarkers for disease diagnosis and prognosis

Yang Jia, Wei Tan, Yedi Zhou

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Challenges and strategies of clinical application of CAR-T therapy in the treatment of tumors—a narrative review

Weijing Li, Lili Wu, Chen Huang, Ruixia Liu, Zheng Li, Lihong Liu, Baoen Shan

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Current role of imaging in COVID-19 infection with recent recommendations of point of care ultrasound in the contagion: a narrative review

Darshan Gandhi, Nitin Jain, Kanika Khanna, Shuo Li, Love Patel, Nishant Gupta

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Future of immune checkpoint inhibitors: focus on tumor immune microenvironment

Yunlong Jia, Lihua Liu, Baoen Shan

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In vivo retinal imaging in translational regenerative research

Ifat Sher, Daniel Moverman, Hadas Ketter-Katz, Elad Moisseiev, Ygal Rotenstreich

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The effect of intestinal flora on immune checkpoint inhibitors in tumor treatment: a narrative review

Dan Wang, He Hao, Xing Li, Zhiyu Wang

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Management of hyponatremia associated with acute porphyria—proposal for the use of tolvaptan

Isabel Solares, Marta Tejedor, Daniel Jericó, Monserrat Morales-Conejo, Rafael Enríquez de Salamanca, Antonio Fontanellas, Alberto Tejedor-Jorge

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Case Report

Novel AMBRA1-ALK fusion identified by next-generation sequencing in advanced gallbladder cancer responds to crizotinib: a case report

Yuling Zhou, Analyn Lizaso, Xinru Mao, Nong Yang, Yongchang Zhang

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Hyperprogressive disease in advanced cancer patients with liver metastasis treated with PD-1 inhibitors: two case reports

Zhuangbin Lin, Qing Liu, Qiongyin Wei, Lan Lin, Xiangqi Chen, Dan Xue

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Transanal minimally invasive surgery (TAMIS) for rectal tumor: a case report and literature review

Huipeng Wang, Tao Ye, Jun Chen, Lifeng Gong, Wenjie Chen, Jiamen Shen, Jiaying Zhao, Yuankun Cai

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Editorial on Gastroesophageal Cancer 2020¹

Editorial for the series on gastric and gastroesophageal cancer treatment in 2020

Khaldoun Almhanna

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Review Articles on Gastroesophageal Cancer 2020¹

Palliative care for patients with esophageal cancer: a narrative review

Dana L. Guyer, Khaldoun Almhanna, Kanako Y. McKee

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Targeted therapies for gastroesophageal cancers

Andrew Hsu, Rani Chudasama, Khaldoun Almhanna, Alexander Raufi

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Esophageal cancer in Aleppo, Syria 2010–2020: a rare cancer in a war zone

Samer Alhames, Andrew Hsu, Fadi Rustam, Rami Kassar, Mohamad bisher Shihade, Khaldoun Almhanna

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Narrative review of the role of gastroenterologist in the diagnosis, treatment and palliation in gastric and gastroesophageal cancer

Liege I. Diaz, Shruti Mony, Jason Klapman

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A narrative review of Barrett’s esophagus in 2020, molecular and clinical update

Aamir N. Dam, Jason Klapman

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Locoregional gastric cancer: a narrative review of multidisciplinary management

Ari Pelcovits, Khaldoun Almhanna

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Treatment for metastatic adenocarcinoma of the stomach and gastroesophageal junction: 2020

Andrew Hsu, Adam S. Zayac, Aditya Eturi, Khaldoun Almhanna

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Does tumor profile in gastric and gastroesophageal (GE) junction cancer justify off-label use of targeted therapy?—a narrative review

Christopher Del Prete, Arun Muthiah, Khaldoun Almhanna

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Editorial Commentary

Adjuvant EGFR TKIs in NSCLC harboring EGFR mutations: looking for a consensus way

Ilaria Attili, Antonio Passaro, Lorenzo Spaggiari, Gianluca Spitaleri, Filippo de Marinis

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Pembrolizumab (and friends) in pediatric malignancies: should we consider Hodgkin lymphoma a world of its own?

Mattia Algeri, Franco Locatelli

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Oncolytic immunotherapy for metastatic cancer: lessons and future strategies

Zong-Sheng Guo

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Radiotherapy tumor volume for limited-stage small cell lung cancer: less is more

Antonin Levy, Corinne Faivre-Finn

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EGFR and non-small cell lung cancer: implications for surgical practice

Gonzalo Varela, Nuria M. Novoa

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Letter to the Editor

Adjuvant therapy in patients with rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and radical resection in pathological stages I–III

Leonardo S. Lino-Silva, César Zepeda-Najar, Rosa A. Salcedo-Hernández

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Coronavirus disease 19 positivity after negative results from six consecutive tests

Jung Hee Kim, Jong Hyun Baek, Mathieu Boudier-Revéret, Min Cheol Chang

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Serum lactate dehydrogenase level may predict acute respiratory distress syndrome of patients with fever infected by SARS-CoV-2

Yang Zhou, Ning Ding, Guifang Yang, Wen Peng, Fengning Tang, Cuirong Guo, Xiangping Chai

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Erratum

Erratum to the effect of RAS blockers on the clinical characteristics of COVID-19 patients with hypertension

Zheyong Huang, Jiatian Cao, Yumeng Yao, Xuejuan Jin, Zhe Luo, Yuan Xue, Chouwen Zhu, Yanan Song, Ying Wang, Yunzeng Zou, Juying Qian, Kaihuan Yu, Hui Gong, Junbo Ge

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Disclosure:

1. The series “Gastroesophageal Cancer 2020” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Khaldoun Almhanna served as the unpaid Guest Editor for the series.

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Deceased donor kidney transplant in a 70-year-old Jehovah’s Witness patient: to transplant or not to transplant—a case report

Giselle Guerra, Mariella Ortigosa-Goggins, Jeffrey J. Gaynor, Gaetano Ciancio

Obstructive jaundice secondary to fungal infection: a rare case report

Weizhe Zhong, Ping Wang, Chuanyong Zhang, Zhuqing Rao, Xiaowei Wang, Xiongxiong Pan, Haoming Zhou, Xuehao Wang

Editorial

Discovering biomarkers of radioresistance in a radiosensitive cancer: a clinical paradox in nasopharyngeal carcinoma

Laura L.Y. Tan, Melvin L. K. Chua

Liver resection is always a good choice for hepatocellular carcinoma (HCC) patients regardless of Barcelona Clinic Liver Cancer (BCLC) stage: the therapeutic hierarchy

Maria Guarino, Nicola Caporaso, Filomena Morisco

Predictive scores for hepatocellular carcinoma: a race with no winners?

Raffaella Tortora, Marco Guarracino, Giovan Giuseppe Di Costanzo

Infective endocarditis in the 21th century

Francesco Nappi, Cristiano Spadaccio, Christos Mihos

Functional magnetic resonance imaging evaluation of central sensitization in an experimental model of pain in rats with induced endometriosis

Julio Cesar Rosa-e-Silva, Helmer Herren, Juliana Meola, Omero Benedicto Poli-Neto, Ana Carolina Japur de Sá Rosa-e-Silva

Emerging multi-modal diagnostic approaches for moyamoya disease

Jae W. Song, Zhaoyang Fan

Treatment of Barcelona Clinic Liver Cancer Stage C hepatocellular carcinoma: liver resection versus TACE and beyond

Ya Ruth Huo, Hao Xiang, Michael Vinchill Chan

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

COVID-19 is shifting the adoption of wearable monitoring and telemedicine (WearTel) in the delivery of healthcare: opinion piece

Ralph J. Mobbs, Daniel Ho, Wen Jie Choy, Callum Betteridge, Henry Lin

Prevention and treatment of strokes associated with carotid artery stenosis: a research priority

Kosmas I. Paraskevas

Albumin-bilirubin score: an additional tool for the management of patients with hepatocellular carcinoma

Matteo Serenari, Giorgio Ercolani

Combination of biomarkers for the detection of hepatocellular carcinoma

Malin Sternby Eilard, Fredrik Åberg

Hysteroscopic removal of retained products of conception: historic approach or new iteration?

Usha Verma, Frank A. Crespo

Ovarian cancer: state of the art and perspectives of clinical research

Stergios Boussios, Nicholas Pavlidis

Editorial Commentary

New evidence for liver venous deprivation: safety and feasibility for extended liver resections

Jiang Zhang, Christian J. Steib

Veverimer: an advance in base therapy for metabolic acidosis

Clayton Brady, Elie R. Chemaly, James W. Lohr, Mark D. Parker

Diagnosis in interstitial lung disease: highly confident histopathological results from transbronchial cryobiopsy are reliable

Lars Hagmeyer, Sandhya Matthes, Konrad Frank, Winfried Randerath

Multikinase inhibitors to treat hepatocellular carcinoma failures to sorafenib—time has come for a better approach

Saleh A. Alqahtani, Massimo Colombo

Molecular downstaging: a new paradigm for neoadjuvant endocrine therapy

Emanuela Ferraro, Monica N. Fornier

Perifissural nodules: ready for application into lung cancer CT screening?

Anton Schreuder, Cornelia M. Schaefer-Prokop

Distinct metabolic preference of atypical KRAS mutant

Heesun Cheong

It is time to prepare for D-CARE!

Christoph Suppan, Marija Balic

Home spirometry to assess efficacy of pirfenidone in progressive unclassifiable interstitial lung disease: better the devil you know than the devil you don’t

Giacomo Sgalla, Pier-Valerio Mari, Luca Richeldi

Keynote-158 study, FDA granted accelerated approval of pembrolizumab for the treatment of patients with advanced PD-L1-positive cervical cancer

Edith Borcoman, Christophe Le Tourneau

Anti-PD1 monotherapy in hepatocellular carcinoma: a step forward or already behind?

Silvia Catanese, Florian Lordick

Time to stop using hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma?—the SCOOP-2 trial experience

Markus Peck-Radosavljevic, Simona Bota, Florian Hucke

Of fungi and men: role of fungi in pancreatic cancer carcinogenesis

Heling Wang, Mjriam Capula, Bastiaan P. Krom, Dicky Yee, Elisa Giovannetti, Dongmei Deng

Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease

Anirudh R. Gone, Wei Chen

IMPassionate about immunotherapy for TNBC: from change, to revolution and to cure?

Elena Vagia, Massimo Cristofanilli

Tivozanib in advanced inoperable hepatocellular carcinoma: considerations for patients with liver cirrhosis

Hyunwoo Oh, Jeong-Hoon Lee

Exenatide at mealtimes in type 1 diabetes—no MAG1C with exenatide, or with other glucagon-like peptide-1 receptor agonists

Sheila A. Doggrell

Devil in the detail: MET overexpression fails as surrogate marker for MET exon 14 splice site mutations in NSCLC

Matthew R. Strickland, Pasi A. Jänne

Optimizing adjuvant therapy in EGFR-mutated non-small cell lung cancer

Annemarie F. Shepherd, Isabel R. Preeshagul, Narek Shaverdian, Abraham J. Wu, Daphna Y. Gelblum, Daniel R. Gomez, Andreas Rimner, Charles B. Simone II

Paving the way to precision medicine for diabetic kidney disease: the PRIORITY trial

Meir Schechter, Gil Leibowitz, Ofri Mosenzon

Towards a tailored systemic therapy for liver cancer

Rodolfo Sacco, Antonio Facciorusso

The LncRNA, the phosphatase, and the macrophage: can they team up for support in inflammatory diseases?

Marcel Kuhny, Michael Huber

The role of c-MET inhibitors in advanced hepatocellular carcinoma: now and future

Hyun Young Woo, Jeong Heo

Combined locoregional and systemic therapy for advanced hepatocellular carcinoma: finally, the future is obscure

Khashayar Farsad, Nima Nabavizadeh, Adel Kardosh, Janice H. Jou, Willscott E. Naugler, Kenneth J. Kolbeck

Endothelial growth factor receptor-mutant lung cancer and post-operative care management: one size does not fit all

Javeryah Safi, Sarah W. Gordon, Peter Lee, Howard Li, Patrick Nana-Sinkam, Rachit D. Shah, Ray W. Shepherd, Samira Shojaee

Dose escalation in the era of ablative lung irradiation: is more dose better when it comes to delivery of lung stereotactic body radiation therapy?

Fiori Alite, Anand Mahadevan

MET immunochemistry: a reliable screening tool for MET exon 14 skipping mutations in non-small cell lung cancer?

Melinda A. Pruis, Jan H. von der Thüsen, Hendrikus Jan Dubbink

Angiogenesis inhibitors for advanced hepatocellular carcinoma: in search for the right partner

Claudia Campani, Lorenza Rimassa, Nicola Personeni, Fabio Marra

Tenascin-C: an emerging prognostic biomarker in diabetes

Saori Yonebayashi, Kazuko Tajiri, Siqi Li, Akira Sato

Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma—targeting a novel PD-1 epitope to treat hepatocellular carcinoma

Yannick Sebastiaan Rakké, Dave Sprengers, Jaap Kwekkeboom, Jan Nicolaas Maria IJzermans

Comment on a recent genetic study on the risk profile of Hirschsprung’s disease from a pediatric surgeon’s perspective

Nana Nakazawa-Tanaka, Geoffrey J. Lane, Atsuyuki Yamataka

Immune checkpoint inhibitor in liver cancer—unique regional differences

Shuntaro Obi, Takahisa Sato, Shinpei Sato

Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) versus chemotherapy in luminal B early breast cancer: lessons from the CORALLEEN trial

Claudia De Angelis, Michail Ignatiadis, Martine Piccart-Gebhart

Prognostic models in papillary renal cell carcinoma

Kyrollis Attalla, Martin H. Voss, A Ari Hakimi

Transbronchial cryobiopsy for diffuse parenchymal lung diseases: evidence that demands a (favorable) verdict

Matthew Aboudara, Fabien Maldonado

A large randomized clinical trial is necessary to establish the role of camrelizumab in hepatocellular carcinoma

Nishal Ravindran, Paul J. Thuluvath

Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?

Charlotte K. Boughton, Roman Hovorka

A biologically effective dose threshold for stereotactic body radiation therapy—can we put the issue to BED?

Michael Mix, Jeffrey A. Bogart

Cigarette smoking and lung function decline beyond quitting

Jennifer L. Perret, E. Haydn Walters

Safety and preliminary signs of efficacy with the combination of pembrolizumab plus oxaliplatin and S-1 in Japanese gastric cancer patients

Maria Alsina, Elizabeth C. Smyth

Sorafenib plus doxorubicin in advanced hepatocellular carcinoma patients: hope or hype?

Kit Shing, Gerry Kwok, Joanne Chiu, Tan To Cheung, Thomas Yau

Transbronchial cryobiopsy in the diagnosis of interstitial lung diseases: methodologies and perspectives from the Cryo-PID and COLDICE studies

Carey Suehs, Arnaud Bourdin, Isabelle Vachier, Nicolas Molinari, Micaela Romagnoli

Antibiotic stewardship in critically ill patients with suspected ventilator-associated pneumonia

Jumpei Yoshimura, Hideki Hashimoto, Kazuma Yamakawa

Why aren’t we getting consistent results for heart dose and mortality during thoracic radiotherapy?

Jianxin Xue, You Lu, Feng-Ming (Spring) Kong

Tivozanib for hepatocellular carcinoma: not likely a new option

Florian Estrade, Fanny Le Du, Laurence Crouzet, Héloïse Bourien, Léa Muzellec, Julien Edeline

New solutions to old problems—metabolic acidosis in chronic kidney disease

John Sy, Joline L. T. Chen, Kamyar Kalantar-Zadeh

Lenvatinib in elderly hepatocellular carcinoma patients, a new therapeutic option in first line

Gael S. Roth, Bleuenn Brusset, Thomas Decaens

Macrophage depletion: a potential immunomodulator treatment of endometriosis-associated pain?

Thomas M. D’Hooghe, Arne Vanhie, Valerie A. Flores, Hugh S. Taylor

Transarterial chemoembolization (TACE) plus sorafenib: a real winning combination?

Xavier Adhoute, Rodolphe Anty, Marc Bourlière

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Hepatobiliary phase hypointensity on gadobenate dimeglumine- enhanced magnetic resonance imaging may improve the diagnosis of hepatocellular carcinoma

Yueming Li, Jianwei Chen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Liting Wen, Dairong Cao, Jinsheng Hong

Developmental characteristics of the cytokine profile in aqueous humor and its relationship with the inflammatory response in children

Weiyi Lai, Xiaohang Wu, Dongni Wang, Zhenzhen Liu, Duoru Lin, Lanqin Zhao, Weirong Chen, Haotian Lin, Yizhi Liu

Evaluation of factors affecting the visualization of dye after transbronchial dye injection: an animal experiment

Jung Seop Eom, Hyo Yeong Ahn, Yeong Dae Kim, Insu Kim, Hee Yun Seol

A self-reported Frailty Index predicts long-term mortality in hospitalized patients with cirrhosis

You Deng, Lin Lin, Lijun Hou, Xiaofei Fan, Tianming Zhao, Lihong Mao, Xiaoyu Wang, Bangmao Wang, Yingli Ma, Chao Sun

Absent filling of the superficial middle cerebral vein is associated with reperfusion but not parenchymal hematoma in stroke patients undergoing thrombectomy: an observational study

Sheng Zhang, Ruiting Zhang, Bo Jin, Zongjie Shi, Chenguang Li, Yannan Yu, Zhen Wang

Bioinformatic analysis and in vitro validation of a five-microRNA signature as a prognostic biomarker of hepatocellular carcinoma

Wang Li, Xiangshuo Kong, Tao Huang, Lujun Shen, Peihong Wu, Qi-Feng Chen

Mitotically associated long non-coding RNA is a tumor promoter in anaplastic thyroid cancer

Nai-Si Huang, Bo-Wen Lei, Li-Cheng Tan, Peng-Cheng Yu, Xiao Shi, Yu Wang, Qing-Hai Ji, Wen-Jun Wei, Zhong-Wu Lu, Yu-Long Wang

SPECTnet: a deep learning neural network for SPECT image reconstruction

Wenyi Shao, Steven P. Rowe, Yong Du

TP53 mutation and tumoral PD-L1 expression are associated with depth of invasion in desmoplastic melanomas

Llucia Alos, Carla Fuster, Paola Castillo, Pedro Jares, Adriana Garcia-Herrera, Marta Marginet, Fernando Agreda, Ana Arance, Elena Gonzalvo, Mireia Garcia, Susana Puig, Cristina Teixido

Mitral valve repair and surgical ablation for atrial functional mitral regurgitation

Jinmiao Chen, Yulin Wang, Minzhi Lv, Zhaohua Yang, Shijie Zhu, Lai Wei, Tao Hong, Wenjun Ding, Yi Lin, Chunsheng Wang

Development of a simple nonalcoholic fatty liver disease scoring system indicative of metabolic risks and insulin resistance

Seogsong Jeong, Kyuwoong Kim, Jooyoung Chang, Seulggie Choi, Sung Min Kim, Joung Sik Son, Gyeongsil Lee, Won Kim, Sang Min Park

Artesunate alleviates myocardial ischemia/reperfusion-induced myocardial necrosis in rats and hypoxia/reoxygenation-induced apoptosis in H9C2 cells via regulating the FAK/PI3K/Akt pathway

Shunyang Fan, Deyin Zhang, Fuyun Liu, Yuqi Yang, Hongliang Xu

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

MiR-3121-3p promotes tumor invasion and metastasis by suppressing Rap1GAP in papillary thyroid cancer in vitro

Ming Xu, Jun Zhou, Qiulei Zhang, Kehao Le, Zihan Xi, Pengfei Yi, Xiangwang Zhao, Jie Tan, Tao Huang

Impact of cataract screening integrated into establishment of resident health record on surgical output in a rural area of south China

Xuhua Tan, Wei Wang, Yi Zhu, Chuan Chen, Xiaozhang Qiu, Jingmin Xu, Chao Hou, Lixia Luo, Wenyong Huang, Yizhi Liu

A comparison of perioperative safety for breast augmentation in cis- vs. trans patients

Kyle S. Gabrick, Fouad Chouiari, Kitae E. Park, Omar Allam, Mohammed Ali Mozaffari, John A. Persing, Michael Alperovich

Quantifying the causal impact of funding bedside antigen testing on the incidence of respiratory syncytial virus infection in Japan: a difference-in-differences study

Sung-mok Jung, Hyojung Lee, Yichi Yang, Hiroshi Nishiura

Novel electromagnetic-based navigation for percutaneous transforaminal endoscopic lumbar decompression in patients with lumbar spinal stenosis reduces radiation exposure and enhances surgical efficiency compared to fluoroscopy: a randomized controlled trial

Junlong Wu, Shengxiang Ao, Huan Liu, Wenkai Wang, Wenjie Zheng, Changqing Li, Chao Zhang, Yue Zhou

Proton pump inhibitors and the risk of hospital-acquired acute kidney injury in children

Yanqin Li, Mengqi Xiong, Minliang Yang, Long Wang, Sheng Nie, Diankun Liu, Mingjing Pi, Aihua Zhang, Jianhua Mao, Hai-Peng Liu, Huimin Xia, Hong Xu, Zhangsuo Liu, Shipin Feng, Wei Zhou, Xuemei Liu, Yonghong Yang, Yuhong Tao, Yunlin Feng, Chunbo Chen, Mo Wang, Yan Zha, Jian-Hua Feng, Qingchu Li, Shuwang Ge, Jianghua Chen, Yongcheng He, Siyuan Teng, Chuanming Hao, Bi-Cheng Liu, Ying Tang, Wenjuan He, Fan Fan Hou, Xin Xu

A preliminary study on the visual outcomes after LaserACE for presbyopia

Ye Xu, Meiyan Li, Peijun Yao, Ruoyan Wei, Xingtao Zhou

Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk

Guan-Tian Lang, Jin-Xiu Shi, Liang Huang, A-Yong Cao, Chen-Hui Zhang, Chuan-Gui Song, Zhi-Gang Zhuang, Xin Hu, Wei Huang, Zhi-Ming Shao

Cataract complications study: an analysis of adverse effects among 14,520 eyes in relation to surgical experience

Alexander Aaronson, Antti Viljanen, Piotr Kanclerz, Andrzej Grzybowski, Raimo Tuuminen

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Analysis of the strategy of LT4 prescribing and TSH monitoring for thyroid carcinoma after lobectomy

Zhihong Wang, Trevor E. Angell, Wei Sun, Yuan Qin, Liang He, Wenwu Dong, Dalin Zhang, Ting Zhang, Liang Shao, Chengzhou Lv, Ping Zhang, Haixia Guan, Hao Zhang

Spontaneous ventilation video-assisted thoracic surgery for mediastinal tumor resection in patients with pulmonary function deficiency

Weizhe Huang, Hongsheng Deng, Yuting Lan, Runchen Wang, Fan Ge, Zhenyu Huo, Yi Lu, Weiyi Lin, Guo Lin, Wenhua Liang, Hengrui Liang, Jianxing He

ICSI outcomes in patients with orgasmic dysfunction and anejaculation by percutaneous epididymal sperm aspiration (PESA)

Jianzheng Fang, Li Shu, Lingbo Cai, Yugui Cui, Jiayin Liu, Xiaoyu Yang

Effect of cataract surgery on quality of life for patients with severe vision impairment due to age-related macular degeneration

Claudia Taipale, Andrzej Grzybowski, Raimo Tuuminen

Genetic alterations in cfDNA of benign and malignant thyroid nodules based on amplicon-based next-generation sequencing

Siting Cao, Shuang Yu, Yali Yin, Lei Su, Shubin Hong, Yingying Gong, Weiming Lv, Yanbing Li, Haipeng Xiao

Qualitative and quantitative assessment of pendelluft: a simple method based on electrical impedance tomography

Ling Sang, Zhanqi Zhao, Po-Jen Yun, Inéz Frerichs, Knut Möller, Feng Fu, Xiaoqing Liu, Nanshan Zhong, Yimin Li

Real-time surgical margin assessment using ICG-fluorescence during laparoscopic and robot-assisted resections of colorectal liver metastases

Friso B. Achterberg, Babs G. Sibinga Mulder, Ruben P. J. Meijer, Bert A. Bonsing, Henk H. Hartgrink, J. Sven D. Mieog, Aimen Zlitni, Seung-min Park, Arantza Farina Sarasqueta, Alexander L. Vahrmeijer, Rutger-Jan Swijnenburg

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Perception of femininity and attractiveness in Facial Feminization Surgery

Ann Hui Ching, Allister Hirschman, Xiaona Lu, Seija Maniskas, Antonio J. Forte, Michael Alperovich, John A. Persing

Intraoperative thermal insulation in off-pump coronary artery bypass grafting surgery: a prospective, double blind, randomized controlled, single-center study

Lin Jin, Xiaodan Han, Ying Yu, Liying Xu, Huilin Wang, Kefang Guo

Research hotspots and trends analysis of ankylosing spondylitis: a bibliometric and scientometric analysis from 2009 to 2018

Miaomiao Liang, Yan Meng, Siming Zhou, Zhengbo Tao, Lin Tao

Effects of radioactive iodine treatment on cardiovascular disease in thyroid cancer patients: a nationwide cohort study

Kyeong Jin Kim, Ji Eun Song, Ji Yoon Kim, Jae Hyun Bae, Nam Hoon Kim, Hye Jin Yoo, Hee Young Kim, Ji A. Seo, Nan Hee Kim, Juneyoung Lee, Kyung Mook Choi, Sei Hyun Baik, Sin Gon Kim

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Screening and identification of a CD44v6 specific peptide using improved phage display for gastric cancer targeting

Dan Zhang, Jin Huang, Weiming Li, Zhiyong Zhang, Meng Zhu, Yun Feng, Yan Zhao, Yarui Li, Shaoying Lu, Shuixiang He

Comparison of iPTH and calcium levels between total thyroidectomy and lobectomy: a prospective study of 840 thyroid cancers with three years of follow-up

Xiaoli Liu, Xuehai Bian, Changlin Li, Jingwei Xin, Qingfeng Fu, Chunhai Zhang, Fang Li, Jinxi Jiang, Gianlorenzo Dionigi, Hui Sun

Beta-elemene inhibits differentiated thyroid carcinoma metastasis by reducing cellular proliferation, metabolism and invasion ability

Lei Zhao, Jian Wei, Shiqi Wang, Tingting Lang, Xiaoguang Shi, Zhongyan Shan, Weiping Teng

Disparities in survival following surgery among patients with different histological types of N2-III non-small cell lung cancer: a Surveillance, Epidemiology and End Results (SEER) database analysis

Gang Jin, Xin Wang, Cai Xu, Jifeng Sun, Zhiyong Yuan, Jun Wang, Lujun Zhao

Fibrosis index predicts variceal bleeding and reduces need for nonselective beta-blocker in compensated cirrhosis with initial small esophageal varices without red-color sign

Sheng-Fu Wang, Yu-Tung Huang, Chien-Hao Huang, Shang-Hung Chang, Chun-Yen Lin

A comparison of the burden of lung cancer attributable to tobacco exposure in China and the USA

Xiaomei Wu, Bo Zhu, Shuang Xu, Yong Liu, Yifei Bi, Baosen Zhou

A better method for the dynamic, precise estimating of blood/ haemoglobin loss based on deep learning of artificial intelligence

Yu-Jie Li, Li-Ge Zhang, Hong-Yu Zhi, Kun-Hua Zhong, Wen-Quan He, Yang Chen, Zhi-Yong Yang, Lin Chen, Xue-Hong Bai, Xiao-Lin Qin, Dan-Feng Li, Dan-Dan Wang, Jian-Teng Gu, Jiao-Lin Ning, Kai-Zhi Lu, Ju Zhang, Zheng-Yuan Xia, Yu-Wen Chen, Bin Yi

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Study Protocol

PRactice of VENTilation in Patients with Novel Coronavirus Disease (PRoVENT-COVID): rationale and protocol for a national multicenter observational study in The Netherlands

Noor S. Boers, Michela Botta, Annisa M. Tsonas, Anna Geke Algera, Janesh Pillay, Dave A. Dongelmans, Janneke Horn, Alexander P. J. Vlaar, Markus W. Hollmann, Lieuwe D. J. Bos, Frederique Paulus, Ary Serpa Neto, Marcus J. Schultz, The PRoVENT-COVID investigators

Review Article

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Management of internal carotid artery near-occlusion: the need for updated evidence

Constantine N. Antonopoulos, Alexandros Giosdekos, Spyridon N. Mylonas, Christos D. Liapis

Narrative review on serous primary peritoneal carcinoma of unknown primary site: four questions to be answered

Elie Rassy, Tarek Assi, Stergios Boussios, Joseph Kattan, Julie Smith-Gagen, Nicholas Pavlidis

Management of asymptomatic carotid stenosis

J. David Spence

Postoperative Endophthalmitis and Toxic Anterior Segment Syndrome Prophylaxis: 2020 Update

Jesse D. Sengillo, Ying Chen, Diley Perez Garcia, Stephen G. Schwartz, Andrzej Grzybowski, Harry W. Jr Flynn

Treatment of the extracranial carotid artery in tandem lesions during endovascular treatment of acute ischemic stroke: a systematic review and meta-analysis

Joyce Hellegering, Maarten Uyttenboogaart, Reinoud P. H. Bokkers, Mostafa El Moumni, Clark J. Zeebregts, Maarten J. van der Laan

Brain imaging biomarkers of carotid artery disease

Hediyeh Baradaran, Ajay Gupta

Intraoperative risks of radiation exposure for the surgeon and patient

Nathaniel W. Jenkins, James M. Parrish, Evan D. Sheha, Kern Singh

Intraoperative image guidance for cervical spine surgery

Sertac Kirnaz, Harry Gebhard, Taylor Wong, Raj Nangunoori, Franziska Anna Schmidt, Kosuke Sato, Roger Härtl

Sharing of decision-making for infective endocarditis surgery: a narrative review of clinical and ethical implications

Francesco Pollari, Cristiano Spadaccio, Michela Cuomo, Massimo Chello, Antonio Nenna, Theodor Fischlein, Francesco Nappi

Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes

Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique

Narrative review: the holy grail: update on pharmacotherapy for heart failure with preserved ejection fraction

Pablo Alejandro Paz, Barbara Daniela Mantilla, Erwin E. Argueta, Debabrata Mukherjee

Optimal diuretic strategies in heart failure

Sarabjeet S. Suri, Salpy V. Pamboukian

A narrative review of intraoperative floppy iris syndrome: an update 2020

Xue Yang, Zhaochuan Liu, Zhigang Fan, Andrzej Grzybowski, Ningli Wang

Guidelines on prosthetic heart valve management in infective endocarditis: a narrative review comparing American Heart Association/American College of Cardiology and European Society of Cardiology guidelines

Umberto Maria Satriano, Antonio Nenna, Cristiano Spadaccio, Francesco Pollari, Theodor Fischlein, Massimo Chello, Francesco Nappi

Asymptomatic Carotid Stenosis and Risk of Stroke (ACSRS) study: what have we learned from it?

Kosmas I. Paraskevas, Andrew N. Nicolaides, Stavros K. Kakkos

Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis?

Stergios Boussios, Michele Moschetta, Peeter Karihtala, Eleftherios P. Samartzis, Matin Sheriff, George Pappas-Gogos, Mehmet Akif Ozturk, Mario Uccello, Afroditi Karathanasi, Michail Tringos, Elie Rassy, Nicholas Pavlidis

Opioid transdermal delivery system: a useful method for pain management in children

Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attinà, Palma Maurizi, Alberto Romano, Antonio Ruggiero

A pilot protocol and review of triple neuroprotection with targeted hypothermia, controlled induced hypertension, and barbiturate infusion during emergency carotid endarterectomy for acute stroke after failed tPA or beyond 24-hour window of opportunity

Sherif Sultan, Yogesh Acharya, Nora Barrett, Niamh Hynes

Lens regeneration in humans: using regenerative potential for tissue repairing

Zhenzhen Liu, Ruixin Wang, Haotian Lin, Yizhi Liu

New frontiers in esophageal radiology

Eric J. Schmidlin, Ritu R. Gill

Management and prognosis of acute extracranial internal carotid artery occlusion

Lukas Mayer, Astrid Grams, Christian F. Freyschlag, Maria Gummerer, Michael Knoflach

Advances in pharmacotherapy of cataracts

Jingjie Xu, Qiuli Fu, Xiangjun Chen, Ke Yao

A narrative review of the interpretation of guidelines for the treatment of infective endocarditis

Umberto Benedetto, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Marc R. Moon, Francesco Nappi

A management framework for left sided endocarditis: a narrative review

Francesco Nappi, Cristiano Spadaccio, Marc R. Moon

Anesthesiological considerations in emphysema surgery

Philip Woldt, Philipp Kruse, Bjoern Ellger

Narrative review in the current role of angiotensin receptor-neprilysin inhibitors

Jose B. Cruz Rodriguez, Cameron Cu, Tariq Siddiqui

Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery

Luigi Bonavina

Systemic anti-cancer treatment in malignant ovarian germ cell tumours (MOGCTs): current management and promising approaches

Mario Uccello, Stergios Boussios, Eleftherios P. Samartzis, Michele Moschetta

Inflammation of carotid plaques and risk of cerebrovascular events

Pavel Poredos, Igor D. Gregoric, Mateja K. Jezovnik

Personalized-medicine on carotid endarterectomy and stenting

Gaetano Lanza, David Giannandrea, Jessica Lanza, Stefano Ricci, Gian Franco Gensini

Fugitive aerosols in the intensive care unit: a narrative review

Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin

Redo aortic valve replacement for prosthesis endocarditis in patients previously classified as high or prohibitive risk: a narrative review

Francesco Pollari, Renate Ziegler, Francesco Nappi, Irena Großmann, Jörg Steinmann, Theodor Fischlein

Recent developments in intraocular lens power calculation methods—update 2020

Giacomo Savini, Leonardo Taroni, Kenneth J. Hoffer

Environmental triggers of dermatomyositis: a narrative review

Christina E. Bax, Spandana Maddukuri, Adarsh Ravishankar, Lisa Pappas-Taffer, Victoria P. Werth

Intranasal drugs for analgesia and sedation in children admitted to pediatric emergency department: a narrative review

Valeria Pansini, Antonietta Curatola, Antonio Gatto, Ilaria Lazzareschi, Antonio Ruggiero, Antonio Chiaretti

A narrative review of early surgery versus conventional treatment for infective endocarditis: do we have an answer?

Umberto Benedetto, Cristiano Spadaccio, Federico Gentile, Marc R. Moon, Francesco Nappi

Therapeutic strategies in Wilson disease: pathophysiology and mode of action

Wolfgang Stremmel, Ralf Weiskirchen

The modern approach to esophageal palliative and emergency surgery

Anny Godin, Moishe Liberman

Fluorescence-guided surgery of the esophagus

Paul Chandler, Ory Wiesel, Danny A. Sherwinter

The management of carotid restenosis: a comprehensive review

Francesco Stilo, Nunzio Montelione, Rosalinda Calandrelli, Marisa Distefano, Francesco Spinelli, Vincenzo Di Lazzaro, Fabio Pilato

Why are we still debating criteria for carotid artery stenosis?

Victor J. Del Brutto, Heather L. Gornik, Tatjana Rundek

Metformin and ovarian cancer: the evidence

Elina Urpilainen, Ulla Puistola, Stergios Boussios, Peeter Karihtala

Advances in imaging for lung emphysema

Katharina Martini, Thomas Frauenfelder

Lung emphysema and lung cancer: what do we know about it?

Ramón A. Tubío-Pérez, María Torres-Durán, Mónica Pérez-Ríos, Alberto Fernández-Villar, Alberto Ruano-Raviña

Current and future immunotherapy approaches in ovarian cancer

Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk

Ovarian cancer risk assessment in the era of next-generation sequencing

Renata Colombo Bonadio, Jéssica Rojas Crespo, Maria Del Pilar Estevez-Diz

Intraoperative image guidance for lateral position surgery

Peter R. Swiatek, Michael H. McCarthy, Joseph Weiner, Shivani Bhargava, Avani S. Vaishnav, Sravisht Iyer

Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

Administration of dry powders during respiratory supports

Wei-Ren Ke, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Patricia Tang, Lan Chen, Donghao Chen, Hak-Kim Chan

A narrative review of diagnosis of infective endocarditis—imaging methods and comparison

Sanjeet Singh Avtaar Singh, Marco Fabio Costantino, Gianpaolo D’Addeo, Damiano Cardinale, Rosario Fiorilli, Francesco Nappi

The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis—a narrative review article

Wolfgang Stremmel, Martina Lukasova, Ralf Weiskirchen

Telomerase reverse transcriptase promoter mutations in thyroid carcinomas: implications in precision oncology—a narrative review

Xiaotian Yuan, Tiantian Liu, Dawei Xu

Paraesophageal hernia: to fundoplicate or not?

Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan

The modern approach to esophagectomy—review of the shift towards minimally invasive surgery

Daniel P. Dolan, Scott J. Swanson

Lung transplantation for emphysema

Ilhan Inci

Magnetic resonance imaging of carotid plaques: current status and clinical perspectives

Mohamed Kassem, Alexandru Florea, Felix M. Mottaghy, Robert van Oostenbrugge, M. Eline Kooi

Impact of cerebral ischemic lesions on the outcome of carotid endarterectomy

Rodolfo Pini, Andrea Vacirca, Sergio Palermo, Enrico Gallitto, Chiara Mascoli, Mauro Gargiulo, Gianluca Faggioli

Preoperative planning for intraoperative navigation guidance

Shahbaaz A. Sabri, Philip J. York

Intraoperative image guidance for endoscopic spine surgery

Jason I. Liounakos, Gregory W. Basil, Hikari Urakawa, Michael Y. Wang

Current practices on genetic testing in ovarian cancer

Florentia Fostira, Marios Papadimitriou, Christos Papadimitriou

Pulmonary vasodilator use in continuous-flow left ventricular assist device management

Preethi Pirlamarla, Eduardo Rame, Charles Hoopes, Indranee Rajapreyar

Inhaled antibiotics during mechanical ventilation—why it will work

Maxime Desgrouas, Stephan Ehrmann

Inhaled pulmonary vasodilators: a narrative review

Kai Liu, Huan Wang, Shen-Ji Yu, Guo-Wei Tu, Zhe Luo

Hyperthermic intraperitoneal chemotherapy in ovarian cancer: Qui Bono?

John Spiliotis

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Frank Tacke, Ralf Weiskirchen

Non-alcoholic fatty liver diseases: current challenges and future directions

Elke Roeb

Human cutaneous B cells: what do we really know?

Irina Lerman, Drew C. Mitchell, Christopher T. Richardson

Cholesterol, carotid artery disease and stroke: what the vascular specialist needs to know

Kosmas I. Paraskevas, Frank J. Veith, Hans-Henning Eckstein, Jean-Baptiste Ricco, Dimitri P. Mikhailidis

Upfront debulking surgery for high-grade serous ovarian carcinoma: current evidence

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CT imaging features of carotid artery plaque vulnerability

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Evolution of and developments in simultaneous bilateral cataract surgery. Update 2020

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Current state of navigation in spine surgery

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Endovascular embolization in renal trauma: a narrative review

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Antiplatelet and anticoagulation strategies for left ventricular assist devices

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Guideline

Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition)

Zhiyi Zhang, Cibo Huang, Quan Jiang, Yi Zheng, Yi Liu, Shengyun Liu, Yingjuan Chen, Yifang Mei, Changhai Ding, Min Chen, Xin Gu, Dan Xing, Min Gao, Lan He, Zhizhong Ye, Lijun Wu, Jianhua Xu, Pinting Yang, Xuewu Zhang, Yue Zhang, Jinwei Chen, Jin Lin, Like Zhao, Mengtao Li, Wanling Yang, Yixin Zhou, Qing Jiang, Cong-Qiu Chu, Yaolong Chen, Weiya Zhang, Wei-Chung Tsai, Guanghua Lei, Dongyi He, Wei Liu, Yongfei Fang, Darong Wu, Jianhao Lin, Cheng-Chung Wei, Hsiao-Yi Lin, Xiaofeng Zeng

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

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What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

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