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Reviewer of the Month (2021)

In 2021, ATM reviewers continue to make outstanding contributions to the peer review process. The following reviewers are highlighted and commended for their professional effort and enthusiasm in reviews. Let us take this chance to express our heartfelt gratitude for their tremendous effort and valuable contributions to the journal and to the scientific process!

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

Heart Failure Update and Advances in 2021

This series of Annals of Translational Medicine introduces a collection of review articles on the full spectrum of heart failure (HF), given the tremendous growth that the field has experienced over the recent years. The crucial role of guideline directed medical therapy (GDMT) instituted at the primary care level is along with the role of advanced therapies for refractory cases, as both are interconnected and are two poles of a continuum.

Medical Aerosol in Acute and Critical Care

As guest editors of this special series of the Annals of Translational Medicine (ATM), we would like to share with the readers at large the contributions from invited authors who provided their unique and expert perspectives on the important and critical topics of this focus series titled “Medical Aerosols in Acute and Critical Care”.

Artificial Intelligence in Molecular Imaging

This series of articles in Annals of Translational Medicine explores the intersection of MI and AI and hints at the future impact of these rapidly changing technologies. Manuscripts include both original research and review articles that cover topics such as the use of generative adversarial networks (GANs) in medical imaging, molecular neuroimaging, the use of AI for response assessment, and prostate-specific membrane antigen (PSMA)-based therapy in prostate cancer, among others.

Innovations and Updates in Esophageal Surgery

With the goal of serving our patients best by providing them expert and up-to-date care, we hope all physicians- general and thoracic surgeons, gastroenterologists, radiologists and oncologists, will find this concise but thorough review helpful and interesting.

Unresolved Basic Issues in Hepatology

Basic research and comparative human medical advances during the last decades and centuries have significantly improved diagnostic and treatment modalities in Hepatology. However, the evolution of this area has sparked not only scientific and clinical benefits but also controversies. The focused series “Unresolved Basic Issues in Hepatology” contains 13 reviews from leading experts from Australia, Austria, Canada, China, France, Germany, India, UK and USA highlighting current perspectives on hot and often controversial discussed topics in the field of Hepatology.

ATM Annual Report 2020

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2021. In 2020, ATM has made great progress under the join-efforts of experts worldwide.

- More than 1700 papers have been published in ATM in 2020.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,452,243 times in 2020.
- The number of total citations by SCI journals has significantly increased to 21,008 until Dec. 2020
- The pageviews of ATM is increasing significantly, with a total of 2,230,740 hits in 2020.

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Vol 9, No 11 (June, 2021)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Association of heart rate with cardiovascular events and mortality in hypertensive and normotensive population: a nationwide prospective cohort study

Yuebo Wang, Lu Yin, Bo Hu, Lap Ah Tse, Yu Liu, Haibin Ma, Wei Li; on behalf of PURE-China Investigator group

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Adherence to the Standards for Reporting of Diagnostic Accuracy Studies (STARD): a survey of four journals in laboratory medicine

Fei-Fei Zheng, Wei-Hong Shen, Fang Gong, Zhi-De Hu, Giuseppe Lippi, Ana-Maria Šimundić, Patrick M. M. Bossuyt, Mario Plebani, Kaiping Zhang

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Critical appraisal of TNM versus HKU staging system for postoperative prognostic evaluation of hepatocellular carcinoma

Wong Hoi She, Albert C. Y. Chan, Ka Wing Ma, Wing Chiu Dai, Kenneth S. H. Chok, Tan To Cheung, Chung Mau Lo

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Ghrelin attenuates drowning injury via dual effects on damage protection and immune repression

Min Chen, Hongwei Lin, Yanjun Gao, Zaiqiang Wang, Yujuan Li, Faguang Jin

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A rapid near-patient RT-PCR test for suspected COVID-19: a study of the diagnostic accuracy

Paul Hofman, Jacques Boutros, Didier Benchetrit, Jonathan Benzaquen, Sylvie Leroy, Virginie Tanga, Olivier Bordone, Maryline Allégra, Virginie Lespinet, Julien Fayada, Charlotte Maniel, Jennifer Griffonnet, Eric Selva, Giancarlo Troncone, Giuseppe Portella, Thibaut Lavrut, Richard Chemla, Michel Carles, Marius Ilié, Charles Marquette

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Detection of ALK fusion transcripts in plasma of non-small cell lung cancer patients using a novel RT-PCR based assay

Simon Heeke, Jonathan Benzaquen, Audrey Vallee, Maryline Allegra, Julien Mazieres, Julien Fayada, Jaya Rajamani, Michael Lee, Ellen Ordinario, Angelica Tiotiu, Jacques Cadranel, Michel Poudenx, Denis Moro-Sibilot, Fabrice Barlesi, Radj Gervais, Juliette Thariat, Virginie Tanga, Jacques Boutros, Marius Ilié, Véronique Hofman, Charles-Hugo Marquette, Marc G. Denis, Paul Hofman; on behalf of the STALKLUNG01 Study Consortium Investigators

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Temporal haemodynamic changes after bisoprolol treatment in patients with uncontrolled hypertension

Weiwei Zeng, Brian Tomlinson

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Ulinastatin inhibits NLRP3-induced apoptosis in a PD cell model

Yicheng Lin, Dongsheng Xu, Feng Gao, Xiaolei Zheng

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Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients

Lijing Cheng, Meiling Yuan, Shu Li, Zhiying Lian, Junjing Chen, Weibiao Lin, Jianbo Zhang, Shupeng Zhong

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Tregs-derived interleukin 35 attenuates endothelial proliferation through STAT1 in pulmonary hypertension

Naifu Wan, Wuwei Rong, Wentong Zhu, Daile Jia, Peiyuan Bai, Guizhu Liu, Qiangyou Wan, Ankang Lyu

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An analysis of the surgical outcomes of laparoendoscopic single-site myomectomy and multi-port laparoscopic myomectomy

Shi-Fang Zhou, Hai-Yan Wang, Kun Wang

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Brain function state in different phases and its relationship with clinical symptoms of migraine: an fMRI study based on regional homogeneity (ReHo)

Ming Lei, Junjian Zhang

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Clinical evaluation and animal experimental study of different mass concentrations of pingyangmycin in the local injection treatment of lip venous malformation

Weili Yuan, Xukai Wang, Lei Xue, Fang Zhang

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VEGF gene transfection restores the angiogenesis of oral submucous fibrosis in mice

Ying Sun, Tao Wang, Qi-Tao Wen, Da-Hai Yu, Jing-Xin Chen

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LncRNA-GAS5 promotes spinal cord repair and the inhibition of neuronal apoptosis via the transplantation of 3D printed scaffold loaded with induced pluripotent stem cell-derived neural stem cells

Rongxue Shao, Changming Li, Yan Chen, Liang Zhang, Hejie Yang, Zhijing Zhang, Jun Yue, Wenshuo Gao, Hang Zhu, Hao Pan, Hui Zhou, Renfu Quan

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Potential therapeutic targets and biological mechanisms of Centella asiatica on hepatic fibrosis: a study of network pharmacology

Yuli Fan, Xiaoyan Yin

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Moderate calorie restriction ameliorates reproduction via attenuating oxidative stress-induced apoptosis through SIRT1 signaling in obese mice

Shaohong Zhang, Mengxiao Zhang, Shuoshuo Sun, Xiao Wei, Yu Chen, Peng Zhou, Rendong Zheng, Guofang Chen, Chao Liu

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Novel coronavirus pneumonia detection and segmentation based on the deep-learning method

Zhiliang Zhang, Xinye Ni, Guanying Huo, Qingwu Li, Fei Qi

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Ideal cardiovascular health metrics and epicardial adipose tissue volume in a Northern Chinese population: a cross-sectional study

Wenyi Yang, Haiyan Shi, Xin Huang, Yufei Ma, Bo Guan, Shasha Sun, Yan Yu, Jiakun Luo, Fan Tian, Jian Cao

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Pharmacokinetics, pharmacodynamics, and safety of single- and multiple-dose intravenous ceftobiprole in healthy Chinese participants

Wan-Zhen Li, Hai-Lan Wu, Yuan-Cheng Chen, Bei-Ning Guo, Xiao-Fen Liu, Yu Wang, Ju-Fang Wu, Jing Zhang

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Osimertinib for the treatment of epidermal growth factor receptor-mutated non-small cell lung cancer patients with leptomeningeal metastases and different T790M status

Haiyan Xu, Hengqi Chen, Jianxin Kong, Ye Zhang, Shan Liu, Guangjian Yang, Lu Yang, Yan Wang

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Geographic variations in idiopathic epiretinal membranes in China

Mengqiao Xu, Minwen Zhou, Xiaodong Sun, Xiang Shi

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Adaptive immunity-related gene expression profile is correlated with clinical phenotype in patients with acute myeloid leukemia

Peng Chen, Yi Liu, Rui Zhang, Haitao Wang, Juan Zhang, Meng Guo, Zhenlan Du

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Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1β through blocking the NF-κB/HIF-2α signaling pathway

Pengzhen Wang, Yanchen Ye, Wei Yuan, Yanping Tan, Shaoheng Zhang, Qingqi Meng

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Earlier diagnosis improves COVID-19 prognosis: a nationwide retrospective cohort analysis

Yi-Jun Chen, Wen-Hua Jian, Zhen-Yu Liang, Wei-Jie Guan, Wen-Hua Liang, Ru-Chong Chen, Chun-Li Tang, Tao Wang, Heng-Rui Liang, Yi-Min Li, Xiao-Qing Liu, Ling Sang, Lin-Ling Cheng, Feng Ye, Shi-Yue Li, Nuo-Fu Zhang, Zhe Zhang, Ying Fang, Jian-Xing He, Nan-Shan Zhong, Jin-Ping Zheng

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Review Article

The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology—a narrative overview of the literature

Gerrit S. Maier, Manuel Weissenberger, Maximilian Rudert, Klaus E. Roth, Konstantin Horas

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A narrative review of research progress on drug therapies for glioblastoma multiforme

Xiangjin Zheng, Qin Tang, Liwen Ren, Jinyi Liu, Wan Li, Weiqi Fu, Jinhua Wang, Guanhua Du

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A narrative review of multiple endocrine neoplasia syndromes: genetics, clinical features, imaging findings, and diagnosis

Xuefang Hu, Jian Guan, Yangdi Wang, Siya Shi, Chenyu Song, Zi-Ping Li, Shi-Ting Feng, Jie Chen, Yanji Luo

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Scientific landscape and trend analysis of keloid research: a 30-year bibliometric review

Yuming Chong, Xiao Long, Yuh-Shan Ho

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Collection on reports of molecules linked to epithelial-mesenchymal transition in the process of treating metastasizing cancer: a narrative review

Yiyi Cai, Boyuan Wang, Bingying Li, Xintong Huang, Haoyue Guo, Yu Liu, Bin Chen, Sha Zhao, Shengyu Wu, Wei Li, Lei Wang, Keyi Jia, Hao Wang, Peixin Chen, Minlin Jiang, Xuzhen Tang, Hui Qi, Chunlei Dai, Junyan Ye, Yayi He

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A narrative review of hybrid ablation for persistent and longstanding persistent atrial fibrillation

Ali Khoynezhad, Nikhil Warrier, Tiffany Worthington, Adrian Shandling

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Current research advances in microRNA-mediated regulation of Krüppel-like factor 4 in cancer: a narrative review

Xi Yang, Cheng Chen, Li Li, Tian Xiao, Yong-Dong Zou, Duo Zheng

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Surgical Technique

A new patch technique for valve-sparing aortic root repair in acute type A aortic dissection

Ling-Chen Huang, Zheng Xu, Xiao-Fu Dai

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Case Report

Successful treatment of EGFR T790M-mutant non-small cell lung cancer with almonertinib after osimertinib-induced interstitial lung disease: a case report and literature review

Longqiu Wu, Wenjuan Zhong, An Li, Zhengang Qiu, Ruilian Xie, Huaqiu Shi, Shun Lu

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Study Protocol

Laparoscopic total left-sided surgical approach versus traditional bilateral surgical approach for treating hiatal hernia: a study protocol for a randomized controlled trial

Zhi Zheng, Weitao Zhang, Chenglin Xin, Na Zeng, Mengyi Li, Xiaoye Liu, Jun Cai, Fandong Meng, Dong Liu, Jie Zhang, Jie Yin, Jun Zhang, Zhongtao Zhang

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Editorial on Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology¹

Present and future of hyperthermic intrathoracic chemotherapy (HITHOC) in thoracic surgical oncology

Marcello Migliore

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Original Article on Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology¹

Assessment of concentration and penetration depth of cisplatin in human lung tissue after decortication and hyperthermic exposure

Christopher Larisch, Till Markowiak, Elena Loch, Christian Großer, Patrick J. Bednarski, Karolina Mueller, Hans-Stefan Hofmann, Michael Ried

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Review Article on Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology¹

Narrative review of theoretical considerations regarding HITHOC between past and future

Tamas F. Molnar, Andras Drozgyik

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Hyperthermic intrathoracic chemotherapy (HITHOC): narrative review of the current literature, recommendations and future studies

Till Markowiak, Christopher Larisch, Hans-Stefan Hofmann, Michael Ried

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Perioperative anaesthetic management of patients undergoing thoracic cytoreductive surgery and HITHOC

Felipe Unigarro-Londoño, Ricard Navarro-Ripoll, David Sánchez-Lorente, Laureano Molins

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Hypertermic Intrathoracic Chemotherapy (HITHOC) for thymoma: a narrative review on indications and results

Vittorio Aprile, Diana Bacchin, Stylianos Korasidis, Roberta Ricciardi, Iacopo Petrini, Marcello Carlo Ambrogi, Marco Lucchi

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A narrative review of hyperthermic intrathoracic chemotherapy for advanced lung cancer

Kimberly Song, Raja M. Flores

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New horizons in non-small-cell lung cancer patients with ipsilateral pleural dissemination (M1a): review of the literature

Hao Li, Taorui Liu, Zewen Sun, Zhenfan Wang, Xianping Liu, Fan Yang

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Editorial Commentary on Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology¹

Hyperthermic intrathoracic chemotherapy (HITHOC) should be included in the guidelines for malignant pleural mesothelioma

Marcello Migliore, Michael Ried, Laureano Molins, Marco Lucchi, Marcello Ambrogi, Tamas F. Molnar, Hans-Stefan Hofmann

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Disclosure:

1. The series “Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Marcello Migliore served as the unpaid Guest Editor for the series.

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Intensive multidisciplinary treatment strategies and patient resilience to challenge long-term survival in metastatic colorectal cancer: a case report in real life and clinical practice

Gemma Bruera, Francesco Pepe, Umberto Malapelle, Mario Di Staso, Antonella Dal Mas, Daniela Di Giacomo, Gaia Scerbo, Michela Santilli, Eugenio Ciacco, Maurizio Simmaco, Giancarlo Troncone, Claudio Coco, Felice Giuliante, Enrico Ricevuto; on behalf of Oncology Network ASL1 Abruzzo

Editorial

Cancer immunotherapy: recent advances and challenges

Umang Swami, Mohammed Milhem

Ground glass opacities of the lung before, during and post COVID-19 pandemic

Marcello Migliore

Carotid artery stenosis and stroke: controversies in prevention and treatment

Kosmas I. Paraskevas

The importance of being solid for a ground glass opacity of the lung

Luca Bertolaccini, Lorenzo Spaggiari

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

Rare variants: data types and analysis strategies

Chayanika Goswami, Amrita Chattopadhyay, Eric Y. Chuang

Advantages of ocular regeneration research

Susanna S. Park

Letter to the Editor

New insights into mechanisms of Alzheimer’s disease revealed by a dynamic functional magnetic resonance imaging study

Yicheng Long

Response to: effect of vasa vasorum in cerebrovascular compensation: 2 case reports

Long Li, Adam A. Dmytriw, Liqun Jiao

Elevated lipoprotein(a) and risk of coronary heart disease according to different lipid profiles in the general Chinese community population: the CHCN-BTH study

Yong Hu, Yong-Ming He

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Real-world data on the clinicopathological traits and outcomes of hospitalized liver hemangioma patients: a multicenter study

Tengqian Tang, Xishu Wang, Yilei Mao, Jing Li, Tianfu Wen, Weidong Jia, Yongjun Chen, Tao Peng, Lingxiao Liu, Ruifang Fan, Kuansheng Ma, Feng Xia

Newly detected liver nodules with a history of colorectal cancer: are they metastatic? Review of 2,632 cases in a single center

Kai Zhu, Wentao Wang, Rongkui Luo, Danjun Song, Xi Wang, Qiang Gao, Jia Fan, Jian Zhou, Shengxiang Rao, Xiaoying Wang

Vof16-miR-205-Gnb3 axis regulates hippocampal neuron functions in cognitively impaired diabetic rats

Wenfang Peng, Bojin Xu, Xiaoxu Ge, Juan Du, Liuqing Xi, Lili Xia, Qianqian Wang, Shan Huang

Development of a new EGFR antibody antagonist which exhibits potential biological effects against laryngeal cancer

Kai Ren, Binquan Wang, Qingyan Qi

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Three novel mutations in Chinese patients with CSF1R-related leukoencephalopathy

Min Chu, Dong-Xin Wang, Yue Cui, Yu Kong, Li Liu, Ke-Xin Xie, Tian-Xinyu Xia, Jing Zhang, Ran Gao, Ai-Hong Zhou, Chao-Dong Wang, Li-Yong Wu

Findings from the 45 and Up Study: smoking is not associated with the risk of early-onset cataract

Jiaqing Zhang, Xiaotong Han, Wei Wang, Jason Ha, Zhenzhen Liu, Xianwen Shang, Lei Zhang, Xuhua Tan, Mingguang He, Lixia Luo

Clinical comparison of tenosynovial giant cell tumors, synovial chondromatosis, and synovial sarcoma: analysis and report of 53 cases

Wei Wang, Man-Mei Long, Cheng-Jiang Wei, Xi-Wei Cui, Jie-Yi Ren, Yi-Hui Gu, Qing-Feng Li, Shun-Dong Dai, Bin Gu, Zhi-Chao Wang

Norcantharidin triggers apoptotic cell death in non-small cell lung cancer via a mitophagy-mediated autophagy pathway

Zhilong Liu, Baoxia Li, Mingrong Cao, Jianwei Jiang

The effect of docosahexaenoic acid on predicting the survival of patients with idiopathic pulmonary arterial hypertension

Xu Huai, Yuanyuan Sun, Xiuying Sun, Wenhui Wu, Lan Wang, Rong Jiang, Sugang Gong, Jinling Li, Yuqing Miao, Ping Yuan, Qinhua Zhao

Effect of novel bicaval anastomosis technique for transplantation with and without prior cardiac surgery history

Feng Shi, Zongli Ren, Min Zhang, Zhiwei Wang, Zhiyong Wu, Xiaoping Hu, Zhipeng Hu, Hongbing Wu, Wei Ren, Luocheng Li, Yongle Ruan, Rui Hu

Next generation sequencing for diagnosis of central nervous system aspergillosis in liver transplant recipients

Fang Chen, Yujing Zhao, Chuan Shen, Longzhi Han, Xiaosong Chen, Jianjun Zhang, Qiang Xia, Yongbing Qian

Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire as an outcome measure for ossification of posterior longitudinal ligament patients in East Asia: an investigation of reliability, validity, and responsiveness

Shuyang Li, Joe Kodama, Leixin Wei, Tingkui Wu, Hiroyasu Fujiwara, Yukitaka Nagamoto, Lee A. Tan, Yanbin Zhao, Fengshan Zhang, Shengfa Pan, Yu Sun, Feifei Zhou, Takashi Kaito, Peng Cao, Beiyu Wang, Xiaoguang Liu

Evaluation of the reporting quality of guidelines for gastric cancer using the RIGHT checklist

Xuan Wu, Ding Li, Haiyang Chen, Jing Han, Hanqiong Zhou, Zhen He, Yanfang Ma, Bingqi Dong, Yingxi Wu, Kristina A. Matkowskyj, Aslam Ejaz, Khaldoun Almhanna, Qiming Wang

Clinical effectiveness of orthodontic miniscrew implantation guided by a novel cone beam CT image-based computer aided design and computer aided manufacturing (CAD-CAM) template

Lingling Qiu, Hui Xu, Pingping Feng, Xiaoyan Sha, Hongwei Zhang

MCTS1 promotes invasion and metastasis of oral cancer by modifying the EMT process

Zhexun Huang, Qiao Su, Wuguo Li, Hui Ren, Huiqiang Huang, Anxun Wang

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A. Nolta, Susanna S. Park

The ‘Hybrid method’ for the treatment of congenital clubfoot

Federico Canavese, Mounira Mansour, Léa Souchon, Antoine Samba, Alain Dimeglio

The functional method: experience from the Robert Debré Hospital

Philippe Souchet, Jean-Pierre Delaby, Matthieu Campana, Jason Chinnappa, Brice Ilharreborde, Anne-Laure Simon

Safety of immune checkpoint inhibitors in patients with cancer and pre-existing autoimmune disease

Swetha Alexander, Umang Swami, Aneet Kaur, Yubo Gao, Munazza Fatima, Meredith M. Ginn, Jill E. Stein, Petros Grivas, Yousef Zakharia, Namrata Singh

Local FK506 implants in non-human primates to prevent early acute rejection in vascularized composite allografts

Alexandre G. Lellouch, Corentin B. Taveau, Alec R. Andrews, Joseph Molde, Zhi Yang Ng, Philipp Tratnig-Frankl, Ivy A. Rosales, Marion Goutard, Elise Lupon, Laurent A. Lantieri, Robert B. Colvin, Mark A. Randolph, Joachim Kohn, Curtis L. Cetrulo Jr

CT/MRI LI-RADS version 2018 versus CEUS LI-RADS version 2017 in the diagnosis of primary hepatic nodules in patients with high- risk hepatocellular carcinoma

Kun Lv, Xin Cao, Yinlei Dong, Daoying Geng, Jun Zhang

Factors associated with corneal high-order aberrations before and after femtosecond laser-assisted in situ keratomileusis

Jun Zeng, Gongpu Lan, Min Zhu, Kai Sun, Qun Shi, Guoqing Ma, Quan Liu

Feasibility of anterior pedicle screw fixation in lumbosacral spine: a radiographic and cadaveric study

Wei-Xing Xu, Bin Xu, Wei-Guo Ding, Hong-Feng Sheng, Di Lu, Tian-Hong Hu

Clinical course and outcomes of COVID-19 patients with a history of cerebrovascular disease: a retrospective study in Wuhan

Yang Bai, Yong Liang, Fang Wang, Ligang Chen, Yulong Zhao, Shoujie Zhao, Yejing Zhu, Yushu Dong, Guobiao Liang, Dongfeng Chen, Lei Liu

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Problem-based learning and case-based learning in dental education

Haiyan Wang, Jing Xuan, Lijun Liu, Xuemin Shen, Yaoyang Xiong

Virtual reality and 3D printing improve preoperative visualization of 3D liver reconstructions—results from a preclinical comparison of presentation modalities and user’s preference

Florentine Huettl, Patrick Saalfeld, Christian Hansen, Bernhard Preim, Alicia Poplawski, Werner Kneist, Hauke Lang, Tobias Huber

Influence of primary payer status on non-ST-segment elevation myocardial infarction: 18-year retrospective cohort national temporal trends, management and outcomes

Saraschandra Vallabhajosyula, Viral K. Desai, Pranathi R. Sundaragiri, Wisit Cheungpasitporn, Rajkumar Doshi, Vikas Singh, Allan S. Jaffe, Amir Lerman, Gregory W. Barsness

Long-term outcomes of a totally thoracoscopic approach for reoperative mitral valve replacement: a propensity score matched analysis

Peijian Wei, Jian Liu, Jiexu Ma, Yuyuan Zhang, Zhao Chen, Yanjun Liu, Tong Tan, Hongxiang Wu, Jimei Chen, Jian Zhuang, Huiming Guo

Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist

Yongjie Yang, Yanfang Ma, Jingli Lu, Shuzhang Du, Jingmin Zhang, Haiyang Meng, Zhe Chen, Qiwen Zhang, Xiaojian Zhang, Wenyin Shi, Francesco Girolamo, Santiago Cepeda, Jian Kang

A skin in situ immune cell detection kit for the diagnosis and classification of cutaneous lupus erythematosus

Qianwen Li, Kaili Chen, Yueming Deng, Xiguang Liu, Guozhang Ma, Jinrong Zeng, Jianyun Lu, Ming Zhao, Haijing Wu, Qianjin Lu

Pathological features of persistent adnexal masses in pregnancy

Zhiqiang Zhang, Xiaojuan Zheng, Miao Zhang, Jinfeng Li, Jing Zhao, Jing Zheng, Shuzhen Wang

Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes

Christoph Knappich, Thomas Lang, Pavlos Tsantilas, Sofie Schmid, Michael Kallmayer, Bernhard Haller, Hans-Henning Eckstein

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Prevalence and risk of chronic kidney disease in oral lichen planus: a large cross-sectional study from eastern China

Yiwen Deng, Chengyi Wang, Yeqing Shen, Bo Shen, Feng Ding, Guoyao Tang, Wei Liu

Microbubble-mediated sonothrombolysis with BR38 of a venous full blood thrombus in a rat embolic stroke model

Tobias Braun, Laura Sünner, Maaike Hachenberger, Clemens Müller, Astrid Wietelmann, Martin Juenemann, Jörn Pons-Kühnemann, Manfred Kaps, Tibo Gerriets, Marlene Tschernatsch, Joachim Roth, Mesut Yenigün

The central nervous system can directly regulate breast cancer progression and blockage by quercetin

Tianyu Luo, Yanmei Zhang, Xiaoyuan Liu, Qianyi Liang, Ling Zhu, Hai Lu, Huachao Li, Hongyan Zhang, Chunmin Yang, Jiahua Wu, Rui Xu, Yuzhu Zhang, Qianjun Chen

SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases

Baoyan Xu, Qiao Yang, Yingzi Tang, Zhaoxia Tan, Haiyan Fu, Jing Peng, Xiaomei Xiang, Linlin Gan, Guohong Deng, Qing Mao, Pin-Xian Xu, Yi Jiang, Jianqiang Ding

Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration

Juan Zhou, Weiguo Li, Xiang Wen, Dan Zeng, Jilei Lin, Shiyi Chen, Na Zang, Yu Deng, Xiaohong Xie, Luo Ren, Enmei Liu

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration

Un Chul Park, Susanna S. Park, Bo Hee Kim, Sung Wook Park, Young Joo Kim, Whitney Cary, Johnathon D. Anderson, Jan A. Nolta, Hyeong Gon Yu

CYP2C19 genotype has prognostic value in specific populations following coronary stenting

Wenyao Wang, Chunli Shao, Bo Xu, Jingjia Wang, Min Yang, Jing Chen, Kuo Zhang, Siyuan Wang, Ping Li, Yi-Da Tang

SMOX expression predicts the prognosis of non-small cell lung cancer

Zhanghao Huang, Shuo Wang, Hai-Jian Zhang, You Lang Zhou, Jia-Hai Shi

The clinical value of valve metagenomic next-generation sequencing when applied to the etiological diagnosis of infective endocarditis

Sishi Cai, Ye Yang, Jue Pan, Qing Miao, Wenting Jin, Yuyan Ma, Chunmei Zhou, Xiaodong Gao, Chunsheng Wang, Bijie Hu

An evaluation of the reporting quality in clinical practice guidelines for hepatocellular carcinoma using the RIGHT checklist

Haiyang Chen, Meng Tao, Ding Li, Jing Han, Cheng Cheng, Yanfang Ma, Yingxi Wu, Vishal G. Shelat, Francisco Tustumi, Sanjaya K. Satapathy, Koo Jeong Kang, Qiming Wang

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8

Elyse M. Salpeter, Brian C. Leonard, Antonio J. Lopez, Christopher J. Murphy, Sara Thomasy, Denise M. Imai, Kristin Grimsrud, K. C. Kent Lloyd, Jiong Yan, Rossana Sanchez Russo, Suma P. Shankar, Ala Moshiri

Electrolytes and clinical outcomes in patients with acute ischemic stroke or transient ischemic attack

Anxin Wang, Xue Tian, Hongqiu Gu, Yingting Zuo, Xia Meng, Pan Chen, Hao Li, Yongjun Wang

Semi-supervised generative adversarial networks for closed-angle detection on anterior segment optical coherence tomography images: an empirical study with a small training dataset

Ce Zheng, Victor Koh, Fang Bian, Luo Li, Xiaolin Xie, Zilei Wang, Jianlong Yang, Paul Tec Kuan Chew, Mingzhi Zhang

A bibliometric analysis of Wnt signaling pathway: from the top-100 cited articles to emerging trends

Jia-Qi Xu, Ning Tang, Ling-Feng Zhang, Chen Tan, Yang Su, Daniel M. George, Guang-Xu He, Tian-Long Huang

Mechanism of miR-204-5p in exosomes derived from bronchoalveolar lavage fluid on the progression of pulmonary fibrosis via AP1S2

Liang Zhu, Yahui Chen, Mo Chen, Wenwen Wang

DAPK2 activates NF-κB through autophagy-dependent degradation of I-κBα during thyroid cancer development and progression

Yan Jiang, Ji Liu, Hua Xu, Xiao Zhou, Liu He, Chenfang Zhu

Review Article

Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

Sangwan Park, Brian C. Leonard, Vijay Krishna Raghunathan, Soohyun Kim, Jennifer Y. Li, Mark J. Mannis, Christopher J. Murphy, Sara M. Thomasy

The dark side of immunotherapy

Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami

Endovascular management of pelvic trauma

Arlene Weir, Padraic Kennedy, Stella Joyce, David Ryan, Liam Spence, Mark McEntee, Michael Maher, Owen O’Connor

Systematic review of the effectiveness of carotid surgery and endovascular carotid stenting versus best medical treatment in managing symptomatic acute carotid artery dissection

Sherif Sultan, Niamh Hynes, Yogesh Acharya, Edel Kavanagh, Fionnuala Jordan

Treatment of patch infection after carotid endarterectomy: a systematic review

Tim M. Wikkeling, Senne A. van Gijssel, Maarten J. van der Laan, Clark J. Zeebregts, Ben R. Saleem

From Codivilla to Ponseti: historical narrative review on clubfoot treatment in Italy

Flavia Alberghina, Gianluca Testa, Sergio Monforte, Vito Pavone, Antonio Andreacchio

Clinical importance of testing for clopidogrel resistance in patients undergoing carotid artery stenting—a systematic review

Sabine L. Collette, Reinoud P. H. Bokkers, Rudi A. J. O. Dierckx, Maarten J. van der Laan, Clark J. Zeebregts, Maarten Uyttenboogaart

Systematic review of the top 10 ranked spine articles in the last 10 years [2011–2021]

Sihyong J. Kim, Ralph J. Mobbs

Narrative Review of Carotid disease and the kidney

Luca Zanoli, Dimitri P. Mikhailidis

Gene therapy for inherited retinal diseases

Yan Nuzbrokh, Sara D. Ragi, Stephen H. Tsang

CAR T-cell therapy in mature lymphoid malignancies: clinical opportunities and challenges

Mayur Narkhede, Amitkumar Mehta, Stephen M. Ansell, Gaurav Goyal

Immune checkpoint inhibitors in lymphoma: challenges and opportunities

Haris Hatic, Devi Sampat, Gaurav Goyal

Objective analysis of intermediate-term outcome of the Ponseti technique: a review of the experience from Los Angeles

Lewis E. Zionts, Edward Ebramzadeh, Sophia N. Sangiorgio

Impact of carotid stenosis on cerebral hemodynamic failure and cognitive impairment progression: a narrative review

Giovanna Viticchi, Lorenzo Falsetti, Eleonora Potente, Marco Bartolini, Mauro Silvestrini

This is a narrative review of the functional evaluation of clubfoot treatment with gait analysis

Lori A. Karol, Kelly A. Jeans

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

Targeting vascular endothelial growth factor using retinal gene therapy

Sook H. Chung, Sonia L. Frick, Glenn Yiu

Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

Jeff Rytlewski, Mohammed M. Milhem, Varun Monga

Narrative Review of the objective analysis of long-term outcome of the Ponseti technique: experience from Dallas

B. Stephens Richards

Hepatic trauma

Rene Roberts, Rahul A. Sheth

Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Louise B. D. Banning, Stan Benjamens, Reinoud P. H. Bokkers, Clark J. Zeebregts, Robert A. Pol

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

Clubfoot treatment in China before and after the advent of the Ponseti technique: a historical narrative review

Jingchun Li, Yiqiang Li, Hongwen Xu, Federico Canavese

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Endovascular embolization in renal trauma: a narrative review

Tyler Andrew Smith, Adriene Eastaway, Duncan Hartt, Keith Bertram Quencer

Clinical examination and classification systems of congenital clubfoot: a narrative review

Federico Canavese, Alain Dimeglio

Narrative review of ring fixator management of recurrent club foot deformity

Zachery Meyer, Jacob R. Zide, Alexander Cherkashin, Mikhail Samchukov, Daniel D. Bohl, Anthony I. Riccio

Splenic trauma: endovascular treatment approach

Maxwell Cretcher, Catherine E. P. Panick, Alexander Boscanin, Khashayar Farsad

Pluripotent stem cell therapy for retinal diseases

Ishrat Ahmed, Robert J. Johnston Jr, Mandeep S. Singh

Clubfoot management in the Middle East: a survey-based review

Ismat Ghanem, Maroun Rizkallah

Current status of intralesional agents in treatment of malignant melanoma

Misam Zawit, Umang Swami, Hassan Awada, Joyce Arnouk, Mohammed Milhem, Yousef Zakharia

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Narrative review of vascular iatrogenic trauma and endovascular treatment

Tyler Andrew Smith, David Gage, Keith Bertram Quencer

The basic science of optic nerve regeneration

Lindsay Fague, Yin Allison Liu, Nicholas Marsh-Armstrong

MicroRNA and diabetic retinopathy—biomarkers and novel therapeutics

Zeljka Smit-McBride, Lawrence S. Morse

Multimodality carotid plaque tissue characterization and classification in the artificial intelligence paradigm: a narrative review for stroke application

Luca Saba, Skandha S. Sanagala, Suneet K. Gupta, Vijaya K. Koppula, Amer M. Johri, Narendra N. Khanna, Sophie Mavrogeni, John R. Laird, Gyan Pareek, Martin Miner, Petros P. S kakis, Athanasios Protogerou, Durga P. Misra, Vikas Agarwal, Aditya M. Sharma, Vijay Viswanathan, Vijay S. Rathore, Monika Turk, Raghu Kolluri, Klaudija Viskovic, Elisa Cuadrado-Godia, George D. Kitas, Neeraj Sharma, Andrew Nicolaides, Jasjit S. Suri

Narrative review of the management of a relapsed clubfoot

Karim Masrouha, Alice Chu, Wallace Lehman

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Animal models of diabetic retinopathy

Jose Quiroz, Amirfarbod Yazdanyar

The role of gut microbiome in modulating response to immune checkpoint inhibitor therapy in cancer

Abdul Rafeh Naqash, Alba J. Kihn-Alarcón, Chara Stavraka, Kathleen Kerrigan, Saman Maleki Vareki, David James Pinato, Sonam Puri

The quick carotid scan for prevention of strokes due to carotid artery disease

George S. Lavenson Jr, Charles A. Andersen

Clubfoot pathology in fetus and pathogenesis. A new pathogenetic theory based on pathology, imaging findings and biomechanics—a narrative review

Ernesto Ippolito, Giulio Gorgolini

A systematic review of endovascular treatment for chronic total occlusion of the internal carotid artery

Piotr Myrcha, Peter Gloviczki

Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction

Vaia Florou, Sonam Puri, Ignacio Garrido-Laguna, Breelyn A. Wilky

Biomarkers of therapeutic response with immune checkpoint inhibitors

Poorva Bindal, Jhanelle E. Gray, Theresa A. Boyle, Vaia Florou, Sonam Puri

Surgical treatment of locally recurrent rectal cancer: a narrative review

Zhaoya Gao, Jin Gu

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

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Editorial on Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology¹

Original Article on Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology¹

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