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Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

While China’s academic field is flourishing, ATM is blooming and become a choice of publication venue for more and more recognized affiliations. For ATM, it is precisely a type of recognition—by the country's top academic institutions and the most important think tanks in the country in the form of publication venue choice—that makes ATM stay in the scientific research fronts and able to further realize its mission of translating between bench and bedside. ATM's educational value is mostly based on the objective opinions of a group of field experts within the scientific community.

Endovascular Interventions in Trauma

Trauma is a leading cause of death and disability and predominately effects young patients. Trauma teams include many health care professionals from many subspecialties. Endovascular specialists such as interventional radiologists and vascular surgeons play an ever growing role in this team and in the care of these patients. In this focused series on endovascular interventions in trauma, articles will discuss the endovascular treatment of traumatic aortic injury, splenic, hepatic, renal pelvic and extremity trauma. Additionally, we include an article on the emerging technology of resuscitative endovascular balloon occlusion of the aorta (REBOA).

Annals of Translational Medicine (ATM) is now a member of Committee on Publication Ethics (COPE)

Lung Cancer Management—The Next Decade (Ongoing)

This special series on “Lung Cancer Management—The Next Decade” is edited by Dr. Calvin S. H. Ng. Lung cancer remains a disease associated with high morbidity and mortality. It is only in the past decade or so that newer forms of therapies have gradually become available. Targeted and immunotherapies, specialized radiation ion therapies; and operative approaches that are more tailored to the individual with improved precision and lower surgical trauma have been in rapid development.

ATM Annual Report 2021

Greetings from the editorial office of ATM. We wish you a happy new year in 2022. In 2021, ATM has made great progress under the joint-efforts of experts worldwide.

- More than 1800 papers have been published in ATM in 2021.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,860,685 times in 2021.
- The number of total citations by SCI journals has significantly increased to 36,500 till December 2021.
- The pageviews of ATM journal website is increasing significantly, with a total of 2,869,820 hits in 2021.

Highlights in Anesthesia and Critical Care Medicine (Ongoing)

Guest Editors: Tobias Eckle and Benjamin Scott (Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA)

Novel Tools and Therapies for Ocular Regeneration

This special series is very timely since there has been a recent increase in the momentum of translational research in ocular regeneration. This increase stems partially from the success of ocular gene therapy. This special eye series includes review and original articles of novel tools and therapies being developed for ocular regeneration. The goal of this eye series is to provide some overview of the latest research being done in the area of ocular regeneration in order to highlight the broad potential in this field.

Challenges in Clinical Trials (Ongoing)

This special series on “Challenges in Clinical Trials” is edited by Dr. Weiping Wen, Dr. Yanhong Deng, Dr. Qian Shi and Dr. Jun (Vivien) Yin. As with any industry, the challenges facing those working in clinical trials are numerous: from patient recruitment, adoption of technology, regulatory requirements, and spiraling costs. This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.

Carotid Artery Stenosis and Stroke-Prevention and Treatment Part II

Prevention and treatment of ischemic carotid-related strokes is a research priority. All controversial issues should be addressed to optimize patient outcomes. The current series are the second part of two series on the prevention and treatment of carotid artery stenosis and carotid-related strokes. Hopefully, these two series will help to answer many of the current questions and to resolve some of the controversial issues on the topic.

New Impact Factor for Annals of Translational Medicine: 3.932

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2020 citation year: 3.932.

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Reviewer of the Month (2021)

In 2021, ATM reviewers continue to make outstanding contributions to the peer review process. The following reviewers are highlighted and commended for their professional effort and enthusiasm in reviews. Let us take this chance to express our heartfelt gratitude for their tremendous effort and valuable contributions to the journal and to the scientific process!

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

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Vol 10, No 9 (May, 2022)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary

The anti-Trop-2 antibody-drug conjugate Sacituzumab Govitecan—effectiveness, pitfalls and promises

Emanuela Guerra, Saverio Alberti

Annals of Translational Medicine

2022;

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:501

| https://dx.doi.org/10.21037/atm-22-621

(May 2022)

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Original Article

Wedge resection before lobectomy for patients with T1N0M0 non-small cell lung cancer: a propensity score matching analysis

Yuan Zeng, Ying Huang, Junhui Fu, Ke Xu, Wenhua Liang, Fei Cui, Zhexue Hao, Xukai Li, Tuo Xing, Jianxing He, Jun Liu

Annals of Translational Medicine

2022;

(9)

:502

| https://dx.doi.org/10.21037/atm-21-5246

(May 2022)

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Management and prognosis comparison between incidental and nonincidental intravenous leiomyomatosis: a retrospective single-center real-life experience

Peipei Shi, Hongyang Xiao, Hua Li, Wenbin Tang, Aimin Ren, Li Ma, Ruiqin Tu, Sheng Yin, Jiarong Zhang

Annals of Translational Medicine

2022;

(9)

:503

| https://dx.doi.org/10.21037/atm-21-5376

(May 2022)

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Evaluation of the effects of four types of tea on the activity of cytochrome P450 enzymes with a probe cocktail and HPLC-MS/MS

Xueyan Wang, Yanping Liu, Liming Ye, Ying Wei, Yingqiang Fu, Yu Chen, Linchuan Liao

Annals of Translational Medicine

2022;

(9)

:504

| https://dx.doi.org/10.21037/atm-21-5490

(May 2022)

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Chinese contribution to NEJM, Lancet, JAMA, and BMJ from 2011 to 2020: a 10-year bibliometric study

Jinlin Wu, Huili Li, Yan Huang, Guang Tong, Miao Tian, Yanfen Wu, Changjiang Yu, Jue Yang, Ruixin Fan, Tucheng Sun, Xin Li, Jian Zhuang

Annals of Translational Medicine

2022;

(9)

:505

| https://dx.doi.org/10.21037/atm-21-6793

(May 2022)

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High sodium reduced the expression of PTH1R and Klotho by inhibiting 1,25(OH)₂D₃ synthesis in cultured proximal tubule epithelial cells

Jie Gu, Jialin Shi, Xujiao Chen, Jianping Mao, Huaizhou You, Jing Chen

Annals of Translational Medicine

2022;

(9)

:506

| https://dx.doi.org/10.21037/atm-21-5910

(May 2022)

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The gut microbiome contributes to splenomegaly and tissue inflammation in a murine model of primary biliary cholangitis

Cheng-Bo Wang, Yan Wang, Yuan Yao, Jin-Jun Wang, Koichi Tsuneyama, Qiong Yang, Bin Liu, Carlo Selmi, M. Eric Gershwin, Shu-Han Yang, Zhe-Xiong Lian

Annals of Translational Medicine

2022;

(9)

:507

| https://dx.doi.org/10.21037/atm-21-5448

(May 2022)

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The efficacy and safety of chimeric antigen receptor T cells in digestive system cancers: a systematic review and meta-analysis

Zijun Zhao, Junwei Zhang, Jin Bian, Xin Lu

Annals of Translational Medicine

2022;

(9)

:508

| https://dx.doi.org/10.21037/atm-21-5019

(May 2022)

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Effect of GnRH-a pretreatment before frozen-thawed embryo transfer on pregnancy outcome of adenomyosis-associated infertile patients with 56 cm³ ≤ uterine volume ≤100 cm³

Wen Zhang, Bing Han, Caihong Ma, Jie Qiao

Annals of Translational Medicine

2022;

(9)

:509

| https://dx.doi.org/10.21037/atm-21-6247

(May 2022)

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Direct electromagnetic coupling to determine diagnostic bone fracture stiffness

Jakob G. Wolynski, Milan M. Ilić, Kevin M. Labus, Branislav M. Notaroš, Christian M. Puttlitz, Kirk C. McGilvray

Annals of Translational Medicine

2022;

(9)

:510

| https://dx.doi.org/10.21037/atm-21-5315

(May 2022)

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CD106/VCAM-1 distinguishes a fibroblast subpopulation with high colony-forming capacity and distinct protein expression from the uterosacral ligament

Yizhen Sima, Junwei Li, Chengzhen Xiao, Leimei Xu, Ling Wang, Yisong Chen

Annals of Translational Medicine

2022;

(9)

:511

| https://dx.doi.org/10.21037/atm-21-5136

(May 2022)

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Monogenic basis of young-onset cryptogenic stroke: a multicenter study

Wei-Zhuang Yuan, Liang Shang, Dai-Shi Tian, Shi-Wen Wu, Yong You, Cheng-Lin Tian, Bo Wu, Jun Liu, Qin-Jian Sun, Qing Liu, Wei-Hai Xu

Annals of Translational Medicine

2022;

(9)

:512

| https://dx.doi.org/10.21037/atm-21-3843

(May 2022)

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Combining PET with MRI to improve predictions of progression from mild cognitive impairment to Alzheimer’s disease: an exploratory radiomic analysis study

Fan Yang, Jiehui Jiang, Ian Alberts, Min Wang, Taoran Li, Xiaoming Sun, Axel Rominger, Chuantao Zuo, Kuangyu Shi; for the Alzheimer’s Disease Neuroimaging Initiative

Annals of Translational Medicine

2022;

(9)

:513

| https://dx.doi.org/10.21037/atm-21-4349

(May 2022)

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Machine learning-based combined nomogram for predicting the risk of pulmonary invasive fungal infection in severely immunocompromised patients

Chenggong Yan, Peng Hao, Guangyao Wu, Jie Lin, Jun Xu, Tianjing Zhang, Xiangying Li, Haixia Li, Sibin Wang, Yikai Xu, Henry C. Woodruff, Philippe Lambin

Annals of Translational Medicine

2022;

(9)

:514

| https://dx.doi.org/10.21037/atm-21-4980

(May 2022)

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The role of head-up cardiopulmonary resuscitation in sudden cardiac arrest: a systematic review and meta-analysis

Ying Kiat Tan, Ming Xuan Han, Benjamin Yong-Qiang Tan, Ching-Hui Sia, Claire Xin Yi Goh, Aloysius Sheng-Ting Leow, Derek J. Hausenloy, Edwin Shih Yen Chan, Marcus Eng Hock Ong, Andrew Fu Wah Ho

Annals of Translational Medicine

2022;

(9)

:515

| https://dx.doi.org/10.21037/atm-21-4984

(May 2022)

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An analysis of lncRNA-miRNA-mRNA networks to investigate the effects of HDAC4 inhibition on skeletal muscle atrophy caused by peripheral nerve injury

Yuming Gu, Yinghao Lin, Ming Li, Chenyu Zong, Hualin Sun, Yuntian Shen, Jianwei Zhu

Annals of Translational Medicine

2022;

(9)

:516

| https://dx.doi.org/10.21037/atm-21-6512

(May 2022)

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Overexpression of miR-651-5p inhibits ultraviolet radiation-induced malignant biological behaviors of sebaceous gland carcinoma cells by targeting ZEB2

Haiyan Zhao, Xiaochun Yang, Juan Liu, Fang Han, Zhengrong Yang, Zhongyin Hu, Mingzhi Liu, Yan Mei

Annals of Translational Medicine

2022;

(9)

:517

| https://dx.doi.org/10.21037/atm-21-3897

(May 2022)

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Application of one-third tubular steel plates and screws for fixation of medial column in pilon fractures

Zhuo Wang, Jian Zhang, Jin-Shan He, Hong-Wei Gao, Peng-Tao Chen, Yue-Lai Zhou, Yong-Chao Fang, Yao Lu, Le Hu

Annals of Translational Medicine

2022;

(9)

:518

| https://dx.doi.org/10.21037/atm-22-92

(May 2022)

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SLC2A1 plays a significant prognostic role in lung adenocarcinoma and is associated with tumor immunity based on bioinformatics analysis

Yuhang Wang, Hui Wen, Daqiang Sun

Annals of Translational Medicine

2022;

(9)

:519

| https://dx.doi.org/10.21037/atm-22-1430

(May 2022)

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Extraction of entity relations from Chinese medical literature based on multi-scale CRNN

Tingyin Chen, Xuehong Wu, Linyi Li, Jianhua Li, Song Feng

Annals of Translational Medicine

2022;

(9)

:520

| https://dx.doi.org/10.21037/atm-22-1226

(May 2022)

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Identification of immune-related biomarkers in embryos with neural tube defects via a bioinformatics analysis

Qingli Huang, Li Yang, Binbin Nong, Haisi Gan, Huizhen Wu, Meiyan Li, Mingyang Jin, Liling Xie

Annals of Translational Medicine

2022;

(9)

:521

| https://dx.doi.org/10.21037/atm-22-1273

(May 2022)

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Association between bilirubin and nonalcoholic fatty liver disease in the non-obese Chinese population: a cross-sectional study

Xiaochuang Shu, Ya Zheng, Zhaofeng Chen, Qinghong Guo, Yuping Wang, Rui Ji, Yongning Zhou

Annals of Translational Medicine

2022;

(9)

:522

| https://dx.doi.org/10.21037/atm-22-1187

(May 2022)

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Enhancement of LncRNA-HFRL expression induces cardiomyocyte inflammation, proliferation, and fibrosis via the sequestering of miR-149-5p-mediated collagen 22A inhibition

Xiaohua Li, Yun Teng, Miao Tian, Hailong Qiu, Junfei Zhao, Qiang Gao, Yong Zhang, Jian Zhuang, Jimei Chen

Annals of Translational Medicine

2022;

(9)

:523

| https://dx.doi.org/10.21037/atm-22-1756

(May 2022)

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Development and validation of an eight-gene signature based predictive model to evaluate the prognosis of hepatocellular carcinoma patients: a bioinformatic study

Jiehao Zhang, Xin Fu, Nannan Zhang, Weizhen Wang, Hui Liu, Yibin Jia, Yongzhan Nie

Annals of Translational Medicine

2022;

(9)

:524

| https://dx.doi.org/10.21037/atm-22-1934

(May 2022)

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Complications and oncological outcomes after salvage surgery for recurrent and residual hypopharyngeal squamous cell carcinoma: a retrospective cohort study

Ye Zhang, Zehao Huang, Meng Xu, Jie Liu, Zhengjiang Li, Changming An, Shaoyan Liu, Xiaolei Wang

Annals of Translational Medicine

2022;

(9)

:525

| https://dx.doi.org/10.21037/atm-22-1844

(May 2022)

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Establishment of a patient-derived organoid model and living biobank for nasopharyngeal carcinoma

Xian-Wen Wang, Tian-Liang Xia, Hao-Cheng Tang, Xiong Liu, Ri Han, Xiong Zou, Yun-Teng Zhao, Ming-Yuan Chen, Gang Li

Annals of Translational Medicine

2022;

(9)

:526

| https://dx.doi.org/10.21037/atm-22-1076

(May 2022)

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Review Article

The characteristics of fundus microvascular alterations in the course of glaucoma: a narrative review

Xintong Fan, Yue Ying, Ruyi Zhai, Qilian Sheng, Yanan Sun, Huan Xu, Xiangmei Kong

Annals of Translational Medicine

2022;

(9)

:527

| https://dx.doi.org/10.21037/atm-21-5695

(May 2022)

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Artificial intelligence and anesthesia: a narrative review

Valentina Bellini, Emanuele Rafano Carnà, Michele Russo, Fabiola Di Vincenzo, Matteo Berghenti, Marco Baciarello, Elena Bignami

Annals of Translational Medicine

2022;

(9)

:528

| https://dx.doi.org/10.21037/atm-21-7031

(May 2022)

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Case Report

A simple and practical intraoperative ventilation technique for uniportal video-assisted thoracoscopic tracheal reconstruction: a case report

Pan Wang, Qiang Wang, Wenjie Zhang, Hui Zheng, Jun Zhao

Annals of Translational Medicine

2022;

(9)

:529

| https://dx.doi.org/10.21037/atm-21-6215

(May 2022)

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Letter to the Editor

Comment on comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients: a systematic review and meta-analysis

Jiangfeng Wu, Lifang Ge, Qiaoqian Chen, Anli Zhao, Yinghong Guo

Annals of Translational Medicine

2022;

(9)

:530

| https://dx.doi.org/10.21037/atm-22-323

(May 2022)

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Comparison of in vitro maturation and in vitro fertilization for polycystic ovary syndrome patients—reply letter

Yalan Xu, Jie Qiao

Annals of Translational Medicine

2022;

(9)

:531

| https://dx.doi.org/10.21037/atm-2022-7

(May 2022)

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Erratum

Erratum to long-term chest CT follow-up in COVID-19 Survivors: 102–361 days after onset

Editorial Office

Annals of Translational Medicine

2022;

(9)

:532

| https://dx.doi.org/10.21037/atm-2022-2

(May 2022)

PDF Full Text Open Access

Erratum to clinical impact of craniopharyngioma classification based on location origin: a multicenter retrospective study

Editorial Office

Annals of Translational Medicine

2022;

(9)

:533

| https://dx.doi.org/10.21037/atm-2022-9

(May 2022)

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

The removal of floating right heart thrombi and pulmonary embolus using AngioJet device and venoarterial extracorporeal membrane oxygenation: a case report

Guang Chen, Xiaolong Zhang, Qin Wang, Jie Qin, You-Zu Xu, Xiang Li, Fei Li, Xiang Wang, Bin Hu, Haiwei Chu, Dexing Zheng, Jiecheng Zhang, Wenjun Zhao, Lingping Ma

Single-port combined subsegment resection (RS3b + S1bi) with a rare branching segment pattern of the bronchi and vessels: case report and literature review

Zhengxin Yin, Lianggang Zhu, Xianfei Zhang, Hecheng Li

Editorial

Growing contributions of Chinese authors in the plastic and reconstructive surgery literature

Kathy S. He, Johnny I. Efanov

Does everyone understand the terminology ‘borrowed’ from computer sciences creeping into medical sciences?

Gurinder Singh

Editorial Commentary

Sacituzumab govitecan in triple-negative breast cancer

Alexandre de Nonneville, Anthony Goncalves, Emilie Mamessier, François Bertucci

Letter to the Editor

The promises and challenges of pragmatism: lesson from of a recent clinical trial

Xiaoxi Yao, Peter A. Noseworthy

The iPad/iPhone 3D photography app—a promising device, but how about its accuracy?

Wanlin Fan, Alexander C. Rokohl, Yongwei Guo, Ludwig M. Heindl

Reply to letter to the editor: “The iPad/iPhone 3D photography app—a promising device, but how about its accuracy?”

Yuming Chong, Xinyu Liu, Mai Shi, Jiuzuo Huang, Nanze Yu, Xiao Long

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Prognostic value of CD247 in patients with head and neck squamous cell carcinoma: bioinformatic analysis of TCGA database

Peng Lin, Xiao-Li Hu, Yuan-Yuan Hu, Mai-Ying Liu, Qian-Yu Wang, Yan Ding, Jia-Cai Ye

The prognostic value of chemotherapy or/and radiotherapy in adenoid cystic carcinoma and adenoid basal carcinoma of the uterine cervix

Kun Liu, Yong Shi, Lili Qiao, Guodong Deng, Ning Liang, Jian Xie

Network pharmacology and bioinformatics analysis identified essential genes of Jingulian in the treatment of rheumatoid arthritis and COVID-19

Haiyan Zhou, Changchao Zou, Bing Wang, Chao Li, Muzhi Lin, Lili Mo, Bei Zhang, Niwen Huang, Bo Wei, Xiufang Yang, Wupeng Liu, Guobao Xiong, Zheng Shen, Wei Zhou, Xingde Liu, Wei Li, Mingzhu Gao

Surface-based morphological patterns associated with neuropsychological performance, symptom severity, and treatment response in Parkinson’s disease

Jiajie Mo, Bowen Yang, Xiu Wang, Jianguo Zhang, Wenhan Hu, Chao Zhang, Kai Zhang

Gut microbiome dysbiosis in patients with hepatitis B virus-related hepatocellular carcinoma after extended hepatectomy liver failure

Yu-Chong Peng, Jing-Xuan Xu, Chuan-Fa Zeng, Xin-Hua Zhao, Le-Qun Li, Lu-Nan Qi

Fluoride-coated high-purity magnesium cage promotes bone fusion in goat models

Luchao Yu, Yu Sun, Mingfei Wang, Yinghao Wu, Xiaonong Zhang, Jianguang Xu

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Personalized tooth-supported digital guide plate used in the treatment of trigeminal neuralgia with balloon compression

Wen-Bin Wei, Yi-Wen Wang, Zi-Xiang Han, Zhi-Yang Liu, Yue-Min Liu, Min-Jie Chen

A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer

Shunsheng Lin, Runge Fan, Wenyu Li, Wei Hou, Youkun Lin

Identification of novel drug targets for the risk and prognosis of COVID-19

Yi-Han Gan, Ya-Nan Ou, Yu-Xiang Yang, Yue-Ting Deng, Yi Liu, Lan Tan, Jin-Tai Yu

Automatic bleeding detection in laparoscopic surgery based on a faster region-based convolutional neural network

Surong Hua, Junyi Gao, Zhihong Wang, Palashate Yeerkenbieke, Jiayi Li, Jing Wang, Guanglin He, Jigang Jiang, Yao Lu, Qianlan Yu, Xianlin Han, Quan Liao, Wenming Wu

Long-term effects of total vs. partial pancreatectomy among patients with pancreatic cancer: a population-based study

Zhiwen Yang, Qiang Tao, Salamu Mijiti, Dandong Luo, Xiang Tang, Jia Liu, Lingmin Jiang, Zonghao Liu, Chen Liang, Xinyue Tu, Peng Zhao, Andreas Minh Luu, Francesco Serra, Roberta Gelmini, Yong Wang, Yun Zheng

The relationship between serum exosome HBV-miR-3 and current virological markers and its dynamics in chronic hepatitis B patients on antiviral treatment

Weiqiang Gan, Xi Chen, Zeqian Wu, Xiang Zhu, Jing Liu, Tong Wang, Zhiliang Gao

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Preparation and identification of an anti-nicarbazin monoclonal antibody and its application in the agriculture and food industries

Hong Shen, Qiqi Zhao, Bilian Chen, Chao Li, Jue Li, Han Sun, Yu Chen, Wanqin Chen, Yu Yi, Jianfeng Mei, Yanlu Zhang, Guoqing Ying

The better surgical timing and approach for orbital fracture: a systematic review and meta-analysis

Jian Zhang, Xin He, Yanxiu Qi, Pingping Zhou

Transthyretin-induced increase in circ_0007411 represses neovascularization of human retinal microvascular endothelial cells in hyperglycemia via the miR-548m/PTPN12/SKP1/EGFR pathway

Di Hu, Yikun Tian, Lu Ye, Yu Xin, Jun Shao

The research status of central venous catheterization-associated thrombosis: a bibliometrics analysis

Yan Sun, Xuedan Li, Yan Zhang, Sheng Tang

Transcriptome sequencing analysis revealed the molecular mechanism of podoplanin neutralization inhibiting ischemia/ reperfusion-induced microglial activation

Shuang Qian, Lei Qian, Ye Yang, Jie Cui, Yiming Zhao

Screening of periodontitis-related genes and immune cells based on an integrated bioinformatics analysis

Qiang Ban, Xiaofang Ling, Hui Ding, Jiansheng Meng, Yuan Li, Juanfei Zhang, Mingyi Zhu

Establishment of normal reference range for thromboelastography based on 17,708 cases in Beijing, China

Chao Wei, Jin-Yang Zhao, Shu-Ying Wang, Hui-Ning Sun, Nai-Zhe Guan

Bioinformatic analyses of the role of m6A RNA methylation regulators in abdominal aortic aneurysm

Changgeng Fu, Linghe Feng, Jiawei Zhang, Dajun Sun

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Lipid-lowering treatment in a rabbit model of atherosclerosis: a vessel wall magnetic resonance imaging study

Yejun Wu, Fangbing Li, Yilin Wang, Tianxiang Hu, Lianbo Gao

New classification for advanced breast cancer patients experiencing disease progression during salvage treatment: a single-center retrospective cohort study

Jiahuai Wen, Liping Ren, Wenxia Li, Junhong Li, Lezhen Huang, Zhongyu Yuan, Qianjun Chen

Myocardial protection of propofol on apoptosis induced by anthracycline by PI3K/AKT/Bcl-2 pathway in rats

Xiaobei Zhang, Xiaokun Wang, Xiaofeng Liu, Weihao Luo, Hongwei Zhao, Yiqing Yin, Kuibin Xu

Choroid automatic segmentation and thickness quantification on swept-source optical coherence tomography images of highly myopic patients

Menghan Li, Jian Zhou, Qiuying Chen, Haidong Zou, Jiangnan He, Jianfeng Zhu, Xinjian Chen, Fei Shi, Ying Fan, Xun Xu

Acute intermittent porphyria: prevalence of pathogenic HMBS variants in China, and epidemiological survey in Hebei Province, China

Liyan Ma, Yu Tian, Xuan Qi, Pei Li, Jie Li, Qing Teng, Yuelin Ma, Songyun Zhang

External verification and improvement of the Neo-Bioscore staging system in a Chinese cohort

Rui Geng, Ningning Min, Yiqiong Zheng, Chenyan Hong, Wuri Lige, Huan Wu, Yufan Wei, Yanjun Zhang, Xiru Li

Development and validation of the interpretability analysis system based on deep learning model for smart image follow-up of nail pigmentation

Yanqing Chen, Haofan Liu, Zhaoying Liu, Yang Xie, Yingxue Yao, Xiaofen Xing, Han Ma

DeepSSR: a deep learning system for structured recognition of text images from unstructured paper-based medical reports

Hao Liu, Huijin Wang, Jieyun Bai, Yaosheng Lu, Shun Long

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Uncorrected near vision acuity and associated factors in a coastal province in southern China: the Fujian eye cross sectional study

Qinrui Hu, Yang Li, Xueying Qin, Tao Ren, Bin Wang, Yonghua Hu, Xiaoxin Li

User acceptance of wearable intelligent medical devices through a modified unified theory of acceptance and use of technology

Zheng Yin, Jiayu Yan, Shengyu Fang, Dongbo Wang, Demin Han

A localization method for guide pin insertion points in the treatment of femoral neck fracture with closed reduction and percutaneous cannulated screw fixation

Lingsen Yang, Yang Li, Lu Qi, Wenpeng Xie, Yanhua Chen

VSIG4 overexpression alleviates acute kidney injury of mice via inhibition of M1-macrophages activation

Yan Li, Yong Liu, Furong Li, Yiqin Wang, Kailong Wang, Jinghong Zhao

Resurfacing the complex finger defect and sensation reconstruction with the free distal ulnar artery perforator flap: a self-controlled case series study

Haicheng Dou, Xian Zhang, Yiheng Chen, Guangheng Xiang, Feiya Zhou

Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage

Qi Sun, Ailing Gui, Aihua Zou, Yichen Yan, Shi Qiu, Shun Zhu, Wen Liu, Ji Zuo, Qunling Zhang, Ling Yang

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Current usage and challenges of master protocols—based on survey results by ASA BIOP oncology methodology working group master protocol sub-team

Xiaoyun Li, Chengxing Lu, Kristine Broglio, Paul Bycott, Jie Chen, Qi Jiang, Jianchang Lin, Jingjing Ye, Jun Yin

Single-cell transcriptomic analysis revealing changes in retinal cell subpopulation levels and the pathways involved in diabetic retinopathy

Rui Zhang, Chengyu Huang, Yixuan Chen, Ting Li, Long Pang

Network pharmacological analysis of active components of Tongqiao Huoxue Decoction in the treatment of intracerebral hemorrhage

Ji Wu, Xue-Yu Li, Jing Liang, Jian Xie, Cheng-Neng Deng, Zhi-Jun Chen, Chang-Sheng Lai, Zhao-Jian Yang

Risk factors for C₅ palsy following the posterior spinal process-splitting laminoplasty for cervical ossification of the posterior longitudinal ligament: a case control study

Nan Li, Kaiping Zhao, Yan An, Kai Yan, Bo Liu, Da He

Screening of prognostic immune genes and establishment of prognostic model of cervical adenocarcinoma based on bioinformatics analysis

Yunhua Yi, Jiangxin Sheng, Jichan Nie

Engineered exosomes for targeted delivery of miR-187-3p suppress the viability of hemangioma stem cells by targeting Notch signaling

Ze-Liang Zhao, Chao Liu, Qi-Zhang Wang, Hai-Wei Wu, Jia-Wei Zheng

The combined use of acetazolamide and Rhodiola in the prevention and treatment of altitude sickness

Chengzhu Cao, Huan Zhang, Yongchun Huang, Yameng Mao, Lan Ma, Shoude Zhang, Wei Zhang

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

Global and Chinese publications in plastic surgery journals between 2010 and 2020: a bibliometric analysis

Han Zeng, Xiaolei Jin, Chenzhi Lai

Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis

Li Dai, Shuang Lu, Tianbai Shen, Ying Li, Jianjie Chen

Mutational characteristics of Chinese Han and ethnic minorities in southwestern China: a propensity score matched analysis

Yongchun Zhou, Xin Liu, Yinjin Guo, Zhuoying Li, Shunhui Zhu, Quan Li, Xiaoxiong Wang, Ruijiao Yang, Zhenghai Shen, Hongsheng Li, Yaxi Du, Luyao Ma, Shaocong Shen, Yunyi Lan, Yunchao Huang

The outcome of surgical and non-surgical treatments for traumatic optic neuropathy: a comparative study of 685 cases

Wang Wei, Shang-Feng Zhao, Yong Li, Jia-Liang Zhang, Jiang-Ping Wu, Hao-Cheng Liu, Si Sun, Gui-Dong Song, Jian-Min Ma, Jun Kang

Deletion of the miR-144/451 cluster aggravates lethal sepsis-induced lung epithelial oxidative stress and apoptosis

Fan Wu, Xiaoling Yuan, Weili Liu, Lijun Meng, Xiuru Li, Xiang Gao, Shuting Zhou, Lei Fang, Duonan Yu

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma

Hongcheng Zhu, Hui Chen, Guangzong Chen, Ming Liu, Li Chu, Yu Gu, Yun Chen, Chi Zhang, Qin Qin, Yanan Chen, Weiwei Chen, Jianhong Fan, Yongzhan Nie, Junqiang Chen, Shixiu Wu, Xinchen Sun, Weixin Zhao, Kuaile Zhao

Interference with connective tissue growth factor attenuated fibroblast-to-myofibroblast transition and pulmonary fibrosis

Zhizhou Yang, Mengmeng Wang, Liping Cao, Rui Liu, Yi Ren, Liang Li, Yuhao Zhang, Chao Liu, Wei Zhang, Shinan Nie, Zhaorui Sun

Upregulation of FOXO1 contributes to lipopolysaccharide-induced pulmonary endothelial injury by induction of autophagy

Ying Zhao, Hui Zhang, Shu-Li Zhang, Juan Wei, Liang-Liang Zheng, Jian-Kui Du, Xiao-Yan Zhu, Lai Jiang, Yu-Jian Liu

Yinzhihuang oral liquid protects against non-alcoholic steatohepatitis via modulation of the gut-liver axis in mice

Shuyu Li, Fangyuan Chen, Yanting Zou, Liuxin Ning, Guangcong Zhang, Shuncai Zhang, Qunyan Yao

GFAT1 is highly expressed in cancer stem cells of pancreatic cancer

Zhe Wang, Tiantao Kuang, Wenchuan Wu, Dansong Wang, Wenhui Lou, Dayong Jin, Xuefeng Xu, Lei Zhang

New indication of Chuankezhi injection for steroid-resistant focal segmental glomerulosclerosis and its mechanism of action

Rui Liang, Xiang-Na Yang, Shan Lin, Wei-Qing Yi, Xiao-Gang Chen, Xin Dong, Long-Gang Guo, Yan-Kun Li, Yue-Rui Zhao, Hua Xu

Emergency department treatment process planning: a field research, case analysis, and simulation approach

Xiaoyan Huang, Shuai Zhou, Xudong Ma, Zhitao Yang, Yuanyuan Xu, Xiaoxiao Shen, Zengni Zhang, Guang Ning, Erzhen Chen, Na Li, Yong Lu

Electroacupuncture of the Baihui and Shenting acupoints for vascular dementia in rats through the miR-81/IL-16/PSD-95 pathway

Chunmei Ma, Ying Zhou, Wei Yi, Xianxi Zhou, Wenping Guo, Xiaowu Xu, Jing Luo, Ziwei Luo, Aijun Liu, Dongfeng Chen

Review Article

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

A narrative review of research progress on the role of NLRP3 inflammasome in acne vulgaris

Wei Zhu, Hai-Lin Wang, Xian-Le Bu, Jun-Bo Zhang, Yuan-Gang Lu

Sources of bias for single-arm phase II cancer clinical trials

Sin-Ho Jung

Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis

Jiayu Li, Qi Wang, Honghao Wang

Challenges and opportunities in biomarker-driven trials: adaptive randomization

Yeonhee Park

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review

Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu

Novel clinical trial design and analytic methods to tackle challenges in therapeutic development in rare diseases

Yimei Li, Rima Izem

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Reflections from a NMOSD case with serum AQP4-Ab negativity but CSF positivity: narrative review of how to interpret AQP4-Ab test results

Qun Xue, Shugang Cao, Qianyun Rui

Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology

Weihua Zhang, Haitao Ren, Xiaotun Ren, Fang Fang, Hongzhi Guan

The emerging roles of machine learning in cardiovascular diseases: a narrative review

Liang Chen, Zhijun Han, Junhong Wang, Chengjian Yang

Treatment and application of stem cells from different sources for cartilage injury: a literature review

Pengzhen Wang, Shaoheng Zhang, Qingqi Meng, Pingping Zhu, Wei Yuan

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Narrative review of autoantibodies in idiopathic inflammatory myopathies

Yilin Liu, Yiming Zheng, Hongjun Hao, Yun Yuan

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Focal cryotherapy for prostate cancer: a contemporary literature review

Srinath Kotamarti, Thomas J. Polascik

CIRMI—a new term for a concept worthy of further exploration: a narrative review

Gladness Dakalo Nethathe, Jeffrey Lipman, Ronald Anderson, Charles Feldman

Erratum

Erratum to the downregulation of miR-129-5p relieves the inflammatory response in acute respiratory distress syndrome by regulating PPARγ-mediated autophagy

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Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

From bud to blossom: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in Annals of Translational... More >>

ATM Annual Report 2021

Greetings from the editorial office of ATM. We wish you a happy new year in 2022. In 2021, ATM has made great progress under the joint-efforts of experts worldwide. More >>

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