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New Impact Factor for Annals of Translational Medicine: 3.932

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2020 citation year: 3.932.

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Reviewer of the Month (2021)

In 2021, ATM reviewers continue to make outstanding contributions to the peer review process. The following reviewers are highlighted and commended for their professional effort and enthusiasm in reviews. Let us take this chance to express our heartfelt gratitude for their tremendous effort and valuable contributions to the journal and to the scientific process!

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

Heart Failure Update and Advances in 2021

This series of Annals of Translational Medicine introduces a collection of review articles on the full spectrum of heart failure (HF), given the tremendous growth that the field has experienced over the recent years. The crucial role of guideline directed medical therapy (GDMT) instituted at the primary care level is along with the role of advanced therapies for refractory cases, as both are interconnected and are two poles of a continuum.

Medical Aerosol in Acute and Critical Care

As guest editors of this special series of the Annals of Translational Medicine (ATM), we would like to share with the readers at large the contributions from invited authors who provided their unique and expert perspectives on the important and critical topics of this focus series titled “Medical Aerosols in Acute and Critical Care”.

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Vol 9, No 14 (July, 2021)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary

Molecule-based osteoarthritis diagnosis comes of age

Zhongyang Lv, Dongquan Shi

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Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both?

Daniel V. Santi, Luc Cabel, François-Clément Bidard

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Human albumin infusion strategy in liver cirrhosis: liberal or restrictive?

Zhaohui Bai, Gang Cheng, Nahum Méndez-Sánchez, Xingshun Qi

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Original Article

Three-dimensional facial scanner in the hands of patients: validation of a novel application on iPad/iPhone for three-dimensional imaging

Yuming Chong, Xinyu Liu, Mai Shi, Jiuzuo Huang, Nanze Yu, Xiao Long

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En bloc procurement of porcine abdominal multiple organ block for ex situ normothermic machine perfusion: a technique for avoiding initial cold preservation

Chuanbao Chen, Maogen Chen, Xiaohong Lin, Yiwen Guo, Yihao Ma, Zhitao Chen, Weiqiang Ju, Xiaoshun He

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Proteins in plasma as a potential biomarkers diagnostic for pelvic organ prolapse

Tao Wang, Yuqing Liu, Ling Mei, Tao Cui, Dongmei Wei, Yueyue Chen, Xiaoli Zhang, Linbo Gao, Shihong Zhang, Lanfang Guo, Pei Yang, Xiaoyu Niu

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Analysis of the dynamic relationship between immune profiles and the clinical features of patients with COVID-19

Pingping Ren, Chaohong Zhu, Yongchun He, Hong Jiang, Jianghua Chen

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Implementing sequencing-based surveillance in developing countries: findings from a pilot rollout for hepatitis A in China

Xiaotong Hu, Wenting Zhou, Li Zhang, Jingjing Lv, Bingyu Yan, Yang Zhou, Weijun Hu, Yuanyuan Dong, Biyu Chen, Man Liu, Jingyuan Cao, Fujie Xu, Lanjuan Li

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Dexamethasone-loaded thermo-sensitive hydrogel attenuates osteoarthritis by protecting cartilage and providing effective pain relief

Qi-Shan Wang, Bing-Xin Xu, Kai-Jian Fan, Yun-Shan Fan, Hui Teng, Ting-Yu Wang

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Biomechanical testing of three coracoclavicular ligament reconstruction techniques with a 3D printing navigation template for clavicle-coracoid drilling

Ji Qi, Shijie Fu, Ruiyue Ping, Kai Wu, Ziyu Feng, Yanxiao Xu, Xiaoguang Guo, Dingkun Lin, Lei Zhang

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Research hotspots and trends of microRNA in periodontology and dental implantology: a bibliometric analysis

Kang Gao, Yiping Dou, Menghao Lv, Yihui Zhu, Sitong Hu, Pan Ma

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Bepridil, a class IV antiarrhythmic agent, can block the TREK-1 potassium channel

Ying Wang, Zhijie Fu, Zhiyong Ma, Na Li, Hong Shang

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Mid-aortic syndrome is associated with increased left ventricular mass index in Takayasu arteritis

Xu Meng, Lin Zhao, Xueqi Dong, Xiongjing Jiang, Jun Cai, Huimin Zhang, Wenjun Ma, Haiying Wu, Ying Lou, Linping Wang, Xianliang Zhou

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Protective role of 17β-estradiol treatment in renal injury on female rats submitted to brain death

Roberto Armstrong-Jr, Fernanda Yamamoto Ricardo-da-Silva, Marina Vidal-dos-Santos, Cristiano de Jesus Correia, Lucas Ferreira Anunciação, Raphael dos Santos Coutinho e Silva, Luiz Felipe Pinho Moreira, Henri Gerrit Derk Leuvenink, Ana Cristina Breithaupt-Faloppa

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Enlarged perivascular spaces and hemorrhagic transformation after acute ischemic stroke

Quhong Song, Yajun Cheng, Yanan Wang, Junfeng Liu, Chenchen Wei, Ming Liu

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Risk factors associated with surveillance loss after endoscopic submucosal dissection in patients with gastric neoplasm

Manwoo Lee, Kyungchul Kim, Yong Kang Lee, Byung Kyu Park, San Lee, Han Ho Jeon

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Regional and remote connectivity patterns in focal extratemporal lobe epilepsy

Wenyu Liu, Qiang Yue, Qiyong Gong, Dong Zhou, Xintong Wu

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Value of artificial intelligence model based on unenhanced computed tomography of urinary tract for preoperative prediction of calcium oxalate monohydrate stones in vivo

Lei Tang, Wuchao Li, Xianchun Zeng, Rongpin Wang, Xiushu Yang, Guangheng Luo, Qijian Chen, Lihui Wang, Bin Song

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Nomogram for predicting pathologic complete response after transarterial chemoembolization in patients with hepatocellular carcinoma

Jian Lin, Xiaowei Li, Xiaodong Shi, Lei Zhang, Hongzhi Liu, Jingfeng Liu, Kui Wang, Feng Shen

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The polymorphism of the CARD8 inflammasome-related gene is associated with glutamic-acid-decarboxylase-antibody positivity in patients with type 1 diabetes mellitus

Haipeng Pang, Xiaoxiao Sun, Shuoming Luo, Jian Lin, Xiajie Shi, Yang Xiao, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou

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Initial experience with a robotic hepatectomy program at a high-volume laparoscopic center: single-center experience and surgical tips

Boram Lee, YoungRok Choi, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han

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Cost-effectiveness analysis of hemodialysis plus hemoperfusion versus hemodialysis alone in adult patients with end-stage renal disease in China

Haiyin Wang, Huajie Jin, Wendi Cheng, Xiaoxiao Qin, Yashuang Luo, Xin Liu, Yuyan Fu, Gengru Jiang, Wei Lu, Chunlin Jin, Mark Pennington

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The effect of enhanced bone marrow in conjunction with 3D-printed PLA-HA in the repair of critical-sized bone defects in a rabbit model

Zhiqing Liu, Wenxiang Chu, Linyuan Zhang, Yueting Wang, Zanjing Zhai, Fengxiang Liu

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Previous mode of delivery affects subsequent pregnancy outcomes: a Chinese birth register study

Xiaoxu Chen, Jinsong Gao, Juntao Liu, Jing Hu, Sijian Li, Yabin Tang, Mei Zhong, Jing He, Sibiu Liao, Jimmying Yang, Xiaowei Liu, Xietong Wang, Xiaohong Liu, Xinghui Liu, Yinli Cao, Tianyun Wang, Caixia Liu, Jingxia Sun

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Reliability and agreement of the central and mid-peripheral corneal thickness measured by a new Scheimpflug based imaging

A-Yong Yu, Junming Ye, Giacomo Savini, Yiran Wang, Tianjiao Zhang, Min Chen, Qinmei Wang, Jinhai Huang

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Problem-based learning and case-based learning in dental education

Haiyan Wang, Jing Xuan, Lijun Liu, Xuemin Shen, Yaoyang Xiong

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Cost-effectiveness analysis of genotype screening and therapeutic drug monitoring in patients with inflammatory bowel disease treated with azathioprine therapy: a Chinese healthcare perspective using real-world data

Dayong Zeng, Xiaoting Huang, Shen Lin, Rongfang Lin, Xiuhua Weng, Pinfang Huang

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Assessment of racial differences in the incidence of thrombocytopenia induced by trastuzumab emtansine: a systematic review and meta-analysis

Jingyi Zhang, Yaning Yang, Ru Chen, Shanshan Chen, Jiayu Wang, Yang Luo, Fei Ma, Binghe Xu, Ying Fan

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A modified suture technique for the treatment of patients with pernicious placenta previa and placenta accreta spectrum: a case series

Lei Zhu, Junli Lu, Wenyang Huang, Jing Zhao, Menghui Li, Huiyu Zhuang, Yanfang Li, Hao Liu, Lingyun Du

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The efficacy of different instruments combined with Nd:YAP in endodontic retreatment

Fan Cheng, Yaqin Zhu

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Atorvastatin improves bone marrow endothelial progenitor cell function from patients with immune-related hemocytopenia

Juan Qian, Qian Shen, Chun-Xia Yan, Hong Yin, Xin Cao, Zeng-Hua Lin, Yi-Feng Cai, Hong Liu

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The association of homocysteine, folate, vitamin B12, and vitamin B6 with fracture incidence in older adults: a systematic review and meta-analysis

Tao He, Xiangyun Jin, Yee Sin Koh, Qingyu Zhang, Chao Zhang, Fanxiao Liu

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Selection of high-producing clones by a relative titer predictive model using image analysis

Weihong Tao, Waqas Ahmed, Meijin Guo, Ali Mohsin, Bing Wu, Rongxiu Li

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The mechanisms of Chuanxiong Rhizoma in treating spinal cord injury based on network pharmacology and experimental verification

Bo Tao, Qi Wang, Jiangang Cao, Yimingjiang Yasen, Lei Ma, Chao Sun, Jun Shang, Shiqing Feng

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Prognostic factors of patients with small cell lung cancer after surgical treatment

Cheng Zeng, Nana Li, Feng Li, Peng Zhang, Kai Wu, Donglei Liu, Song Zhao

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The effects of GelMA hydrogel on nerve repair and regeneration in mice with spinal cord injury

Hongcheng Zhang, Jinhui Xu, Saijilafu

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CD73 expression in myeloid-derived suppressor cells is correlated with clinical stages in head and neck squamous cell carcinomas

Weihui Zheng, Ying Zhu, Xiaolong Chen, Jianqiang Zhao

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Chemerin/ChemR23 signaling mediates the effects of ultra-high molecular weight polyethylene wear particles on the balance between osteoblast and osteoclast differentiation

Fengchao Zhao, Dingwei Cang, Jianzhi Zhang, Li Zheng

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Novel ETV1 mutation in small cell lung cancer transformation resistant to EGFR tyrosine kinase inhibitors

Yan Zhou, Hao Bai, Jinjing Xia, Wang-Yang Xu, Lei Cheng, Liwen Xiong

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A study of the efficacy and tolerability of capecitabine and lobaplatin in advanced HER-2 negative breast cancer patients

Yuan Yuan, Lili Zhang, Zhe Zhang, Yu Qian, Yue Teng

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Skin wound healing promoted by novel curcumin-loaded micelle hydrogel

Ping Zhou, Hao Zhou, Jian Shu, Shaozhi Fu, Zhu Yang

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The clinical features and prognosis of type 4C myocardial infarction in patients with non-ST-segment elevation myocardial infarction

Jixiang Wang, Honggang Gao, Jianyong Xiao, Mingdong Gao, Yin Liu, Jing Gao

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Identifying a possible new target for diagnosis and treatment of postmenopausal osteoporosis through bioinformatics and clinical sample analysis

Ting Liu, Jiajun Huang, Dongni Xu, Yuxi Li

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METTL3-induced UCK2 m⁶A hypermethylation promotes melanoma cancer cell metastasis via the WNT/β-catenin pathway

Hao Wu, Haochao Xu, Dongdong Jia, Tao Li, Liming Xia

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The lncRNA-miRNA-mRNA ceRNA network in mural granulosa cells of patients with polycystic ovary syndrome: an analysis of Gene Expression Omnibus data

Hengxi Chen, Shuting Cheng, Wei Xiong, Xin Tan

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Liraglutide inhibits the progression of prediabetes in rats by reducing Raf-1 kinase inhibitor protein

Fei Gao, Dingying Wu, Lingling Guo, Lixue Wang, Min Hao, Ling Li, Dongmei Ni, Haojie Hao

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TGR5 protects against cholestatic liver disease via suppressing the NF-κB pathway and activating the Nrf2/HO-1 pathway

Haojun Yang, Fengyong Luo, Yi Wei, Yuwen Jiao, Jun Qian, Shuai Chen, Yu Gong, Liming Tang

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Metastatic patterns and prognosis of young lung cancer patients: a population-based study by age

Lan Yang, Fang Fang, Juan Chan, Bojiang Chen, Wenxin Luo, Qing Zhu, Dan Liu, Weimin Li

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Long-term follow-up study of loose combined cutting seton surgery for patients with high anal fistula

Congcong Zhi, Zichen Huang, Dun Liu, Lihua Zheng

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Identification of significant immune-related genes for epilepsy via bioinformatics analysis

Xiaodan Luo, Tao Xiang, Hongmi Huang, Lin Ye, Yifei Huang, Yuan Wu

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Development of a machine learning model to predict the risk of late cardiogenic shock in patients with ST-segment elevation myocardial infarction

Zhixun Bai, Shan Hu, Yan Wang, Wenwen Deng, Ning Gu, Ranzun Zhao, Wei Zhang, Yi Ma, Zhenglong Wang, Zhijiang Liu, Changyin Shen, Bei Shi

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Pharmacokinetics of treprostinil in children with functional single-ventricle pulmonary arterial hypertension: a randomized controlled trial

Xi Chen, Xiao-Man Cai, Ming-Jie Zhang, Jing-Han Xu, Hao Li, Zhuo-Ming Xu

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Clinical impact of craniopharyngioma classification based on location origin: a multicenter retrospective study

Wenfu Hu, Binghui Qiu, Fen Mei, Jian Mao, Lizhi Zhou, Fan Liu, Jun Fan, Yi Liu, Ge Wen, Songtao Qi, Yun Bao, Jun Pan

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Cost-effectiveness of Anbainuo plus methotrexate compared to conventional disease-modifying antirheumatic drugs for rheumatoid arthritis patients in China

Feng Tian, Zhenhua Wen, Jingyang Li, Xiaowen Luo, Li Deng, Liang Zhang, Jingyun He, Fangling Yao, Zheng Liao

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The potential differential diagnosis value and clinical significance of CD35 expression in B-chronic lymphoproliferative disorders

Yu Shi, Lu Liu, Hui Yang, Xiao Chen, Yan Wang, Sishu Zhao, Huimin Jin, Yujie Wu

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Assessment of liver injury using indocyanine green fluorescence imaging

Yan Chen, Ge Liu, Yulin Wu, Huiming Cai

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Evaluation of the roles and regulatory mechanisms of PD-1 target molecules in NSCLC progression

Yun-Qiang Zhang, Ye Yuan, Jun Zhang, Cheng-Yi Lin, Jia-Long Guo, Hua-Song Liu, Qiang Guo

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Comprehensive analysis of prognostic predictors for patients with limited-stage small-cell lung cancer who underwent resection followed by adjuvant chemotherapy

Jian Feng, Yiyang Wang, Wenhua Yao, Jizhuang Luo, Keke Yu

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Cannabinoid receptor agonist WIN55212-2 reduces unpredictable mild stress-induced depressive behavior of rats

Chao-Chao Zhong, Ya-Nan Gao, Xin-Chong Huang, Xiang Zhu, Hai-Hang Miao, Xing-Guo Xu, Yi-Bin Qin

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MiR-519d-5p modulates the sensitivity of breast cancer to chemotherapy by forming a negative feedback loop with RELA

Ding Li, Tingting Wang, Zelei Yu, Yi Zhang, Xuan Wu, Ning Zheng, Wenzhou Zhang, Lixian Wu

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Evaluation of the reporting quality of clinical practice guidelines on melanoma using the RIGHT checklist

Yongjie Yang, Yanfang Ma, Jingli Lu, Qiwen Zhang, Kelei Guan, Kefeng Liu, Jian Kang, Shuzhang Du, Shu Tang, Xuehui Liu, Ailing Zhang, Dirk Schadendorf, Sanjiv S. Agarwala, Xiaojian Zhang

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Evaluation of the reporting quality of clinical practice guidelines on prostate cancer using the RIGHT checklist

Kefeng Liu, Yanfang Ma, Yongjie Yang, Jingli Lu, Jie Zhao, Shuzhang Du, Xuepei Zhang, Chunlei Liu, Francesco Del Giudice, Masaki Shiota, Shingo Hatakeyama, Xiaojian Zhang, Jian Kang

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A quality evaluation of the clinical practice guidelines on breast cancer using the RIGHT checklist

Hanqiong Zhou, Haiyang Chen, Cheng Cheng, Xuan Wu, Yanfang Ma, Jing Han, Ding Li, Geok Hoon Lim, Warren M. Rozen, Naohiro Ishii, Pankaj G. Roy, Qiming Wang

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Reporting quality of practice guidelines on colorectal cancer: evaluation using the RIGHT reporting checklist

Jing Han, Meng Tao, Xuan Wu, Ding Li, Yanfang Ma, Shaheenah Dawood, Colin W. Steele, Ker-Kan Tan, Qiming Wang

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The association between hyperuricemia and left atrial enlargement in healthy adults

Danhong Fang, Na Wang, Qinfen Chen, Gaojun Wu, Jiansheng Wu, Wenbin Zhang, Guosheng Fu

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Hemodynamic changes of anesthesia, pneumoperitoneum, and head-down tilt during laparoscopic surgery in elderly patients

Dongyuan Jin, Hui Yu, Hai Li, Nannan Zhao, Ying Zhang, Junfeng Li, Jian Cui, Danian Tang, Yue Li, Yichao Teng, Ping Zeng

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Phase II study of sequential chemoradiotherapy with L-asparaginase, dexamethasone, ifosfamide, cisplatin, and etoposide (DICE-L) in the early stage of extranodal natural killer (NK)/T-cell lymphoma

Yao Zhang, Yizhen Liu, Zuguang Xia, Jia Jin, Kai Xue, Jiachen Wang, Hui Sun, Fangfang Lv, Xiaojian Liu, Junning Cao, Xiaonan Hong, Ye Guo, Xuejun Ma, Qunling Zhang

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Identification of MAP3K15 as a potential prognostic biomarker and correlation with immune infiltrates in osteosarcoma

Zhuning Chen, Haoran Kong, Zhaopeng Cai, Keng Chen, Boyang Wu, Haonan Li, Peng Wang, Yanfeng Wu, Huiyong Shen

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The impact of body composition parameters on severe toxicities in patients with locoregionally advanced nasopharyngeal carcinoma undergoing neoadjuvant chemotherapy

Xing Xing, Xin Zhou, Youqi Yang, Yujiao Li, Chaosu Hu, Chunying Shen

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Azithromycin induces apoptosis in airway smooth muscle cells through mitochondrial pathway in a rat asthma model

Liqin Wu, Juan Yin, Qi Zhang, Meiyan Wang, Wei Dai, Jian Zhou, Yuanrong Dai

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Plasma proteomic profiling reveals biomarkers associated with aortic dilation in patients with bicuspid aortic valve

Wenrui Ma, Jingjing Zhang, Kehua Xu, Shiqiang Yan, Dingqian Liu, Hui Huang, Yuyi Tang, Guoquan Yan, Yongxin Sun, Jun Li, Weijia Zhang, Chunsheng Wang, Kai Zhu, Hao Lai

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Combined analysis of C-reactive protein in pleural fluid and serum is effective in the differential diagnosis of exudative pleural effusions

Shuo-Yao Qu, Yong Zhang, Shuo Wu, Ming-Ming Wang, Ling-Li Liu, Xue-Min Yang, Hui-Liang Shan, Juan-Li Yang, Pei Chen, Xin-Yu Ti

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The integration of bevacizumab improves tumor response and survival in patients with refractory cervical cancer treated with radical chemoradiotherapy

Hua Yang, Ying Zhang, Changhao Liu, Bin Feng, Jianjun Zhang, Yan Zhou, Yutian Yin, Jianping Li, Weiwei Li, Vincent Balaya, Mei Shi, Lina Zhao, Lichun Wei

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Protective effects of fucoidan purified from Undaria pinnatifida against UV-irradiated skin photoaging

Rongrong Jing, Keke Guo, Yulan Zhong, Lusheng Wang, Jungang Zhao, Bingyan Gao, Ziyi Ye, Yu Chen, Xuenan Li, Nuo Xu, Xuan Xuan

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Review Article

Biological properties of andrographolide, an active ingredient of Andrographis Paniculata: a narrative review

Vaclav Vetvicka, Luca Vannucci

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Uncovering the pathophysiology of irritable bowel syndrome by exploring the gut-brain axis: a narrative review

He-Yong Tang, Ai-Juan Jiang, Xi-Yang Wang, Hao Wang, Yuan-Yuan Guan, Fei Li, Guo-Ming Shen

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Application of artificial intelligence in gastrointestinal disease: a narrative review

Jun Zhou, Na Hu, Zhi-Yin Huang, Bin Song, Chun-Cheng Wu, Fan-Xin Zeng, Min Wu

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Narrative review of pembrolizumab for the treatment of esophageal cancer: evidence and outlook

Zixian Jin, Jianfei Shen, Chunguo Wang, Dong Chen, Bo Zhang, Jian Zhang, Jaffer A. Ajani, Jaafar Bennouna, Joseph Chao, Harry H. Yoon, Hongyu Zhu, Yuhang Ruan, Chengchu Zhu, Anyi Xu

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Case Report

Diagnosing scrub typhus without eschar: a case report using metagenomic next-generation sequencing (mNGS)

Jie Li, Changwen Chen, Fangqiang Zou, Lin Liu, Baolong Wang, Huan Kang, Binsen Liu, Shouhong Wang, Tiehe Qin

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Editorial on Endovascular Interventions in Trauma

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

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Review Article on Endovascular Interventions in Trauma

Emerging approaches to pre-hospital hemorrhage control: a narrative review

Leila Jamal, Aman Saini, Keith Quencer, Izzet Altun, Hassan Albadawi, Aditya Khurana, Sailendra Naidu, Indravadan Patel, Sadeer Alzubaidi, Rahmi Oklu

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Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

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Splenic trauma: endovascular treatment approach

Maxwell Cretcher, Catherine E. P. Panick, Alexander Boscanin, Khashayar Farsad

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Hepatic trauma

Rene Roberts, Rahul A. Sheth

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Endovascular management of pelvic trauma

Arlene Weir, Padraic Kennedy, Stella Joyce, David Ryan, Liam Spence, Mark McEntee, Michael Maher, Owen O’Connor

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Endovascular interventions in the management of acute extremity trauma: a narrative review

Aditya Khurana, Keith Quencer, Aman Saini, Andrew Sill, Hassan Albadawi, Leila Jamal, Sailendra Naidu, Indravadan Patel, Sadeer Alzubaidi, Rahmi Oklu

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Endovascular embolization in renal trauma: a narrative review

Tyler Andrew Smith, Adriene Eastaway, Duncan Hartt, Keith Bertram Quencer

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Narrative review of vascular iatrogenic trauma and endovascular treatment

Tyler Andrew Smith, David Gage, Keith Bertram Quencer

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Editorial on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II¹

Carotid artery stenosis and stroke: controversies in prevention and treatment

Kosmas I. Paraskevas

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Original Article on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II¹

Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes

Christoph Knappich, Thomas Lang, Pavlos Tsantilas, Sofie Schmid, Michael Kallmayer, Bernhard Haller, Hans-Henning Eckstein

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Review Article on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II¹

The quick carotid scan for prevention of strokes due to carotid artery disease

George S. Lavenson Jr, Charles A. Andersen

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A systematic review of endovascular treatment for chronic total occlusion of the internal carotid artery

Piotr Myrcha, Peter Gloviczki

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Preclinical carotid atherosclerosis as an indicator of polyvascular disease: a narrative review

Pavel Poredos, Mateja K. Jezovnik

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Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Louise B. D. Banning, Stan Benjamens, Reinoud P. H. Bokkers, Clark J. Zeebregts, Robert A. Pol

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Multimodality carotid plaque tissue characterization and classification in the artificial intelligence paradigm: a narrative review for stroke application

Luca Saba, Skandha S. Sanagala, Suneet K. Gupta, Vijaya K. Koppula, Amer M. Johri, Narendra N. Khanna, Sophie Mavrogeni, John R. Laird, Gyan Pareek, Martin Miner, Petros P. Sfikakis, Athanasios Protogerou, Durga P. Misra, Vikas Agarwal, Aditya M. Sharma, Vijay Viswanathan, Vijay S. Rathore, Monika Turk, Raghu Kolluri, Klaudija Viskovic, Elisa Cuadrado-Godia, George D. Kitas, Neeraj Sharma, Andrew Nicolaides, Jasjit S. Suri

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New insight into biology, molecular diagnostics and treatment options of unstable carotid atherosclerotic plaque: a narrative review

Arkadiusz Migdalski, Arkadiusz Jawien

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A narrative review of the pathophysiology of ischemic stroke in carotid plaques: a distinction versus a compromise between hemodynamic and embolic mechanism

Laura Mechtouff, Lucie Rascle, Valentin Crespy, Emmanuelle Canet-Soulas, Norbert Nighoghossian, Antoine Millon

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Impact of carotid stenosis on cerebral hemodynamic failure and cognitive impairment progression: a narrative review

Giovanna Viticchi, Lorenzo Falsetti, Eleonora Potente, Marco Bartolini, Mauro Silvestrini

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Narrative Review of Carotid disease and the kidney

Luca Zanoli, Dimitri P. Mikhailidis

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Clinical importance of testing for clopidogrel resistance in patients undergoing carotid artery stenting—a systematic review

Sabine L. Collette, Reinoud P. H. Bokkers, Rudi A. J. O. Dierckx, Maarten J. van der Laan, Clark J. Zeebregts, Maarten Uyttenboogaart

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Systematic review of the effectiveness of carotid surgery and endovascular carotid stenting versus best medical treatment in managing symptomatic acute carotid artery dissection

Sherif Sultan, Niamh Hynes, Yogesh Acharya, Edel Kavanagh, Fionnuala Jordan

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Treatment of patch infection after carotid endarterectomy: a systematic review

Tim M. Wikkeling, Senne A. van Gijssel, Maarten J. van der Laan, Clark J. Zeebregts, Ben R. Saleem

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Erratum

Erratum to chemoprotective effect of atorvastatin against benzo(a)pyrene-induced lung cancer via the inhibition of oxidative stress and inflammatory parameters

Editorial Office

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Erratum to automatic prediction of treatment outcomes in patients with diabetic macular edema using ensemble machine learning

Editorial Office

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Erratum to analysis of endometrial microbiota in intrauterine adhesion by high-throughput sequencing

Editorial Office

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Erratum to isotretinoin induced small vessel vasculitis: a life- threatening pulmonary-renal syndrome—a case report

Editorial Office

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Disclosure:

1. The series “Carotid Artery Stenosis and Stroke: Prevention and Treatment Part II” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Kosmas I. Paraskevas served as the unpaid Guest Editor for the series.

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Liquid biopsy in esophageal cancer: a case report of false-positive circulating tumor DNA detection due to clonal hematopoiesis

Jonathan Spoor, Ben M. Eyck, Peggy N. Atmodimedjo, Maurice P. H. M. Jansen, Jean C. A. Helmijr, John W. M. Martens, Berend J. van der Wilk, J. Jan B. Lanschot, Winand N. M. van Dinjens

Radical resection of solitary tracheal extramedullary plasmacytoma under non-intubated anesthesia: a case report

Yinjun Li, Yu Jiang, Zixuan Su, Hengrui Liang, Jianxing He, Shuben Li

Congestive heart failure associated with POEMS syndrome that was adequately distinguished from cardiac amyloidosis: a case report and literature review

Goshi Hagiwara, Masahisa Arahata, Kohei Hosokawa, Masaya Shimojima, Shinji Nakao

Editorial

Some comments on using of Web of Science Core Collection for bibliometric studies in Ann Transl Med. Vol. 8

Yuh-Shan Ho

Advantages of ocular regeneration research

Susanna S. Park

Editorial Commentary

More promising results of liver intravoxel incoherent motion imaging analysis for the assessment of nonalcoholic steatohepatitis and fibrosis

Yì Xiáng J. Wáng, Ben-Heng Xiao, Cun-Jing Zheng, Ting Li, Nazmi Che-Nordin, Wei Wang

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

Saving critically ill COVID-19 patients with mechanical circulatory support

Rui Li, Senlin Hu, Peng Chen, Jiangang Jiang, Guanglin Cui, Dao-Wen Wang

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8

Elyse M. Salpeter, Brian C. Leonard, Antonio J. Lopez, Christopher J. Murphy, Sara Thomasy, Denise M. Imai, Kristin Grimsrud, K. C. Kent Lloyd, Jiong Yan, Rossana Sanchez Russo, Suma P. Shankar, Ala Moshiri

Interaction between hepatitis B virus infection and the efficacy of camrelizumab in combination with apatinib therapy in patients with hepatocellular carcinoma: a multicenter retrospective cohort study

Guosheng Yuan, Rong Li, Qi Li, Xiaoyun Hu, Jian Ruan, Wenzhe Fan, Junjie Wang, Wei Huang, Mengya Zang, Jinzhang Chen

Mechanical thrombectomy reduces the gap in treatment outcomes of ischemic stroke between hospital levels of care: analysis of a Korean nationwide data

Kwon-Duk Seo, Min Jin Kang, Jae Kwang Lee, Sang Hyun Suh, Kyung-Yul Lee

The effects of smoking and drinking on the oral and esophageal microbiota of healthy people

Zhengqi Li, Yong Liu, Lizhou Dou, Yueming Zhang, Shun He, Deli Zhao, Wei Zhang, Guiqi Wang

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Diagnostic prediction of ovine fracture healing outcomes via a novel multi-location direct electromagnetic coupling antenna

Jakob G. Wolynski, Kevin M. Labus, Jeremiah T. Easley, Branislav M. Notaroš, Milan M. Ilić, Christian M. Puttlitz, Kirk C. McGilvray

Current usage of stereotactic body radiotherapy for oligometastatic prostate cancer in Korea: patterns of care survey (KROG 19-08)

Sun Hyun Bae, Won Il Jang, Hyun-Cheol Kang, Young Il Kim, Yong Ho Kim, Woo Chul Kim, Hee Kwan Lee, Jin Ho Kim

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Cost-effectiveness analysis of camrelizumab in the second-line treatment for advanced or metastatic esophageal squamous cell carcinoma in China

Fan Yang, Yu Fu, Arun Kumar, Mingsheng Chen, Lei Si, Sirikan Rojanasarot

Nomograms-based prediction of overall and cancer-specific survivals for patients diagnosed with major salivary gland carcinoma

Zhiyong Guo, Zilin Wang, Yige Liu, Jing Han, Jiannan Liu, Chenping Zhang

CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer

Yue Shi, Tao Han, Chong Liu

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

The clinical value of valve metagenomic next-generation sequencing when applied to the etiological diagnosis of infective endocarditis

Sishi Cai, Ye Yang, Jue Pan, Qing Miao, Wenting Jin, Yuyan Ma, Chunmei Zhou, Xiaodong Gao, Chunsheng Wang, Bijie Hu

Guideline-directed low-density lipoprotein management in high-risk ischemic stroke or transient ischemic attack admissions in China from 2015 to 2019

Hong-Qiu Gu, Kai-Xuan Yang, Xin Yang, Chun-Juan Wang, Tian-Jie Lyu, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Chelsea Liu, Hao Li, Yong Jiang, Yong-Jun Wang, Zi-Xiao Li

Predicted outcomes of subdividing M1-stage metastatic lung cancer based on the prognosis and the response to local consolidative therapy

Fang Wang, Jiani Gao, Yijiu Ren, Hang Su, Yunlang She, Dong Xie, Chang Chen

Ozone induces BEL7402 cell apoptosis by increasing reactive oxygen species production and activating JNK

Shuiying Tang, Bihong Xu, Jincheng Li, Meifeng Zhong, Ziyang Hong, Wei Zhao, Tao Zeng, Xiaofeng He

Risk factors for radiation induced lymphopenia in patients with breast cancer receiving adjuvant radiotherapy

Fang Chen, Hao Yu, Hong Zhang, Yaqing Nong, Qian Wang, Haiman Jing, Ying Han, Junjie Wu, Zheng Zhou, Li Yang, Zhiyuan Xu, Yaya Liu, Pingfu Fu, Jian-Yue Jin, Victor Hsue, Amy Chang, Feng-Ming (Spring) Kong

Long-term chest CT follow-up in COVID-19 Survivors: 102–361 days after onset

Xi Yin, Xiaoqing Xi, Xiangde Min, Zhaoyan Feng, Basen Li, Wei Cai, Chanyuan Fan, Liang Wang, Liming Xia

Genetically determined low income modifies Alzheimer’s disease risk

Rong-Ze Wang, Yu-Xiang Yang, Hong-Qi Li, Xue-Ning Shen, Shi-Dong Chen, Mei Cui, Yi Wang, Qiang Dong, Jin-Tai Yu

Daidzein ameliorated concanavalin A-induced liver injury through the Akt/GSK-3β/Nrf2 pathway in mice

Shang-Lin Li, Rui Cao, Xiao-Fan Hu, Peng Xiong, Guang-Yuan Zhao, Ya-Nan Xie, Zhi-Min Wang, Ya-Kun Li, Bo Yang, Jun Yang

Effectiveness and safety of bevacizumab in extensive-disease small cell lung cancer: a systemic review and meta-analysis

Jiaxi He, Hui Pan, Jianxing He, Shuben Li

Circular RNA _0015278 inhibits the progression of non-small cell lung cancer through regulating the microRNA 1278/SOCS6 gene axis

Yiwang Ye, Xuan Wu, Feihu Long, Wei Yue, Da Wu, Yuancai Xie

Differences in artificial ligament graft osseointegration of the anterior cruciate ligament in a sheep model: a comparison between interference screw and cortical suspensory fixation

Hong Li, Fangyi Jiang, Yunsheng Ge, Fang Wan, Hongyun Li, Shiyi Chen

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A. Nolta, Susanna S. Park

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

Role of competitive endogenous RNA networks in the pathogenesis of coronary artery disease

Jiebin Zuo, Mengxi Xu, Danning Wang, Weizhe Bai, Gang Li

Application of an indocyanine green-mediated fluorescence imaging navigation system in detecting mice tumors

Xueyan Zhao, Ziyu Wang, Yulin Wu, Huiming Cai

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration

Un Chul Park, Susanna S. Park, Bo Hee Kim, Sung Wook Park, Young Joo Kim, Whitney Cary, Johnathon D. Anderson, Jan A. Nolta, Hyeong Gon Yu

Survival benefit of immune checkpoint inhibitor monotherapy in patients with non-small cell lung cancer recurrence after completely pulmonary resection

Hiroaki Kuroda, Yusuke Takahashi, Suguru Shirai, Hirotomo Takahara, Takeo Nakada, Noriaki Sakakura, Hirokazu Matsushita

Identification of diagnostic and prognostic signatures derived from preoperative blood parameters for oral squamous cell carcinoma

Xiang Wu, Yuan Yao, Yibin Dai, Pengfei Diao, Yuchao Zhang, Ping Zhang, Sheng Li, Hongbing Jiang, Jie Cheng

A novel variant in fibrillin-1 is responsible for early-onset familial thoracic aortic aneurysms in Marfan patients

Yanyu Duan, Haiying Chang, Jiayuan Ling, Shaoqiang Liu, Yiming Zhong

Novel nanoliposomes alleviate contrast-induced acute kidney injury in New Zealand rabbits by mediating inflammatory response

Hong Zhang, Peng Zhang, Xue Zhang, Yanqiu Song, Zhican Zeng, Xiaofeng Fu, Han Fu, Qin Qin, Naikuan Fu, Zhigang Guo

Study Protocol

Diagnosis of acute respiratory distress syndrome (DARTS) by bedside exhaled breath octane measurements in invasively ventilated patients: protocol of a multicentre observational cohort study

Laura A. Hagens, Nanon F. L. Heijnen, Marry R. Smit, Alwin R. M. Verschueren, Tamara M. E. Nijsen, Inge Geven, Marcus J. Schultz, Dennis C. J. J. Bergmans, Ronny M. Schnabel, Lieuwe D. J. Bos; on behalf of the DARTS consortium

Review Article

Gene therapy for inherited retinal diseases

Yan Nuzbrokh, Sara D. Ragi, Stephen H. Tsang

A narrative review of plaque and brain imaging biomarkers for stroke risk stratification in patients with atherosclerotic carotid artery disease

Simone J. A. Donners, Raechel J. Toorop, Dominique P. V. de Kleijn, Gert J. de Borst

Reflections from a NMOSD case with serum AQP4-Ab negativity but CSF positivity: narrative review of how to interpret AQP4-Ab test results

Qun Xue, Shugang Cao, Qianyun Rui

Toward a clinical optoretinogram: a review of noninvasive, optical tests of retinal neural function

Ravi S. Jonnal

Pluripotent stem cell therapy for retinal diseases

Ishrat Ahmed, Robert J. Johnston Jr, Mandeep S. Singh

Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology

Weihua Zhang, Haitao Ren, Xiaotun Ren, Fang Fang, Hongzhi Guan

Methodological and reporting quality of pediatric clinical practice guidelines: a systematic review

Shu Zhang, Lei Wu, Yang Wang, Qi Zhou, Xufei Luo, Joseph L. Mathew, Qi Wang, Yang Song, Yaolong Chen

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Animal models of diabetic retinopathy

Jose Quiroz, Amirfarbod Yazdanyar

Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis

Jiayu Li, Qi Wang, Honghao Wang

Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

Sangwan Park, Brian C. Leonard, Vijay Krishna Raghunathan, Soohyun Kim, Jennifer Y. Li, Mark J. Mannis, Christopher J. Murphy, Sara M. Thomasy

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Targeting vascular endothelial growth factor using retinal gene therapy

Sook H. Chung, Sonia L. Frick, Glenn Yiu

The basic science of optic nerve regeneration

Lindsay Fague, Yin Allison Liu, Nicholas Marsh-Armstrong

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Properties improvement of titanium alloys scaffolds in bone tissue engineering: a literature review

Weiyang Zuo, Lingjia Yu, Jisheng Lin, Yong Yang, Qi Fei

Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review

Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu

A narrative review of tumor heterogeneity and challenges to tumor drug therapy

Liang Zhu, Minlin Jiang, Hao Wang, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu, Zixuan Zheng, Yayi He

MicroRNA and diabetic retinopathy—biomarkers and novel therapeutics

Zeljka Smit-McBride, Lawrence S. Morse

Tailoring glucocorticoids in patients with severe COVID-19: a narrative review

Ming-Hao Luo, Yi-Qi Qian, Dan-Lei Huang, Jing-Chao Luo, Ying Su, Huan Wang, Shen-Ji Yu, Kai Liu, Guo-Wei Tu, Zhe Luo

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

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Editorial on Endovascular Interventions in Trauma

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Editorial on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II1

Original Article on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II1

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Editorial on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II¹

Original Article on Carotid Artery Stenosis and Stroke—Prevention and Treatment Part II¹

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