Home - Annals of Translational Medicine

Ovarian Cancer: State of the Art and Perspectives of Clinical Research

Ovarian cancer is composed of three histological subtypes: epithelial (90%), germ cell (5%), and sex cord stromal cell (5%). Epithelial ovarian cancer (EOC) is the most lethal gynecological disorder due to lack of effective early detection strategies. The forthcoming special series focuses on several key elements that are essential for an understanding of this heterogeneous group of malignancies.

Lung Emphysema

Lung emphysema represents a major public health burden and still accounts for 5% of all deaths worldwide. Hence, it is essential to further understand this disease in order to develop effective diagnostic and therapeutic strategies. In our focused series, we highlight this disease from several aspects beginning with advances in imaging, going through developments of surgical and interventional therapies of lung volume reduction, perioperative anesthesiologic considerations, and giving an overview of the different phenotypes of chronic obstructive disease and correlations between lung cancer and lung emphysema, and concluding with lung transplantation for lung emphysema.

OCT Angiography in Glaucoma

Therefore the review articles published in current series cover several essential and currently under investigation research areas. The reviews are important for all clinicians dealing with glaucoma patients, researchers working on any of the chronic progressive neurodegenerative diseases one of which is glaucoma, and those engineers, mathematicians and physicists whose research involves clinical aspects.

Gastroesophageal Cancer 2020

This series of Annals of Translational Medicine presents a collection of review articles on the treatment of gastric and gastroesophageal cancer in 2020. The treatment of this cancer has been evolving overtime in both the locally advanced and the metastatic setting. Treatment ranges from Endoscopic resection in early stage disease and perioperative chemotherapy in locally advanced disease to combination of chemotherapy and targeted therapy in the metastatic setting.

Carotid Artery Stenosis and Stroke: Prevention and Treatment Part I

The aim of the current series is to provide an outline of the various controversial issues and techniques, as well as to present the strengths and limitations of the various proposed diagnostic imaging modalities that need to be addressed by future research, thus optimizing stroke outcomes for patients.

Perioperative Management of Patients with Undergoing Mechanical Circulatory Support

In conclusion this special edition focuses the attention of the reader on the next step up for mechanical circulatory support. The excellent survival records move towards reducing complications for even better outcomes. We thank the authors who have vast experience in their field and believe these review articles to be not only discussion of published literature but also be seen through the eyes of the practicing doctor. We hope they will be interesting for many specialities medics and allied professionals who are working with patients in advanced heart failure supported by machines.

Hemodynamic Monitoring in Critically Ill Patients

This series of Annals of Translational Medicine presents a collection of review articles on hemodynamic monitoring in the critically ill patient. The limits and scopes of hemodynamic monitoring has broadened over the last decades with the incorporation of new less invasive techniques such as bedside point-of-care echocardiography. On the other hand, resuscitation concepts have changed and moved from a cardiac output centered approach to perfusion-driven strategies.

Tumor Associated Macrophages in Solid Tumor: Friend or Foe

The focused series aims to highlight the current status of TAMs research in context to solid tumors in a preclinical and clinical setting. We have invited distinguished scientists from the different onco- immunology field for this focused series. I hope, the reviews will help the reader to understand in detail macrophages topographical and temporal heterogeneity and functional diversity in different tumor types.

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Vol 9, No 1 (January, 2021)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Is the Barcelona Clinic Liver Cancer guideline for treating intermediate to advanced staged hepatocellular carcinoma still appropriate?

Koo Jeong Kang, Keun Soo Ahn

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Addition of apatinib to transarterial chemoembolization leads to improved outcome in patients with intermediate and advanced hepatocellular cancer

Pauline Viviane Pocha, Chencheng Xie, Christine Pocha

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The addition of radiofrequency ablation for patients receiving sorafenib: new evidence for a new standard?

Michael Lock, Brandon M. Meyers, Amol Mujoomdar

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Original Article

Effect of a medicinal and edible decoction YH0618 on chemotherapy-induced dermatologic toxicity: a randomized controlled trial

Jieshu You, Yanhua He, Hui Zhi, Victor Hofun Lee, Suetmui Chan, Lixing Lao, Huanlan Liu, Jianping Chen

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Dual inhibition of RNAi therapeutic miR-26a-5p targeting cMet and immunotherapy against EGFR in endometrial cancer treatment

Yun Liu, Yixuan Cai, Yue Chang

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Real-world results of the implementation of preoperative anaemia clinic with intravenous iron therapy for treating iron-deficiency anaemia: a propensity-matched case-control study

Hairil R. Abdullah, Tanakorn Thamnachit, Ying Hao, Wan Yen Lim, Li Ming Teo, Yilin Eileen Sim

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What is the optimal number of neoadjuvant chemotherapy cycles for resectable colorectal liver oligometastases?

Qichen Chen, Xingchen Li, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Hong Zhao, Jianqiang Cai

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Short-term dietary restriction ameliorates brain injury after cardiac arrest by modulation of mitochondrial biogenesis and energy metabolism in rats

Minggen Zhou, Tao Yu, Xiangshao Fang, Qiulin Ge, Fengqing Song, Zitong Huang, Longyuan Jiang, Peng Wang

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Endometrial cavity fluid is associated with deleterious pregnancy outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection: a retrospective cohort study

Wen-Xiu Zhang, Lian-Bao Cao, Ying Zhao, Jing Li, Bo-Feng Li, Jia-Nan Lv, Lei Yan, Jin-Long Ma

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Effect of liver injury on prognosis and treatment of hospitalized patients with COVID-19 pneumonia

Guo-Guang Ma, Ya-Xing Shen, Ling Wu, Zhe Luo, Chou-Wen Zhu, Shi-Yao Chen, Kai-Huan Yu, Feng Li

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Prognostic factors for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome: a multicenter study in China

Haitao Shang, Tao Bai, Shenghua Zhu, Xiaoqian Yang, Chang Liu, Dong Xu, Yuzheng Zhuge, Yuhu Song, Xiaohua Hou

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Nomograms based on clinicopathological factors and inflammatory indicators for prediction of early and late recurrence of hepatocellular carcinoma after surgical resection for patients with chronic hepatitis B

Tianxing Dai, Mingbin Deng, Linsen Ye, Guozhen Lin, Rongqiang Liu, Yinan Deng, Rong Li, Wei Liu, Hua Li, Yang Yang, Guihua Chen, Guoying Wang

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Characteristics and clinical subtypes of cancer patients in the intensive care unit: a retrospective observational study for two large databases

Shaowei Gao, Yaqing Wang, Lu Yang, Zhongxing Wang, Wenqi Huang

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A STING-related prognostic score predicts high-risk patients of colorectal cancer and provides insights into immunotherapy

Si-Yuan Chen, Siyu Chen, Wanjing Feng, Ziteng Li, Yixiao Luo, Xiaodong Zhu

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Incidence and prognosis of undifferentiated cancers of the digestive system: a population-based cohort study

Jingping Qiu, Yan Xin

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Clinical results and complications associated with oblique lumbar interbody fusion technique

Cheng Cheng, Kai Wang, Can Zhang, Hao Wu, Fengzeng Jian

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High serum gamma-glutamyl transpeptidase concentration associates with poor postoperative prognosis of patients with hepatitis B virus-associated intrahepatic cholangiocarcinoma

Bo Zhang, Shuang Liu, Binghai Zhou, Lei Guo, Hui Li, Jiuliang Yan, Wentao Zhang, Mincheng Yu, Zheng Chen, Yongfeng Xu, Yongsheng Xiao, Qinghai Ye

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Inhibition of laser induced rats choroidal neovascularization by intravitreous injection of sEphB4-HSA

Shikun He, Sha Ouyang, Xiaohua Li, Binyun Ma

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The trend of indirect anastomosis formation in a 2-vessel occlusion plus encephalo-myo-synangiosis rat model

Wensheng Li, Lei Wei, Bocheng Wang, Shuangqi Gao, Tengchao Huang, Zhangyu Li, Robin Bhattarai, Hui Wang, Ying Guo, Chuan Chen

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The effect of 1.9-mm versus 2.4-mm probes in transbronchial cryobiopsies for interstitial lung diseases: a prospective analysis

Guowu Zhou, Yanhong Ren, Jun Li, Ting Yang, Nan Su, Ling Zhao, Shumeng Wang, Dan Wang, Ying Li, Zheng Tian, Ruihong Liu, Huaping Dai, Chen Wang

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Computed tomography-measured bone mineral density as a surrogate marker of survival after resection of colorectal liver metastases

Shinichi Ikuta, Tsukasa Aihara, Takayoshi Nakajima, Meidai Kasai, Naoki Yamanaka

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Association between comorbid diabetes mellitus and prognosis of patients with sepsis in the intensive care unit: a retrospective cohort study

Shan Lin, Shanhui Ge, Wanmei He, Mian Zeng

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Rapid, accurate, multifunctional and self-assisted vision assessment and screening with interactive desktop autostereoscopy

Xiaoke Li, Jing Zhong, Yiyao Wang, Hantao Zhang, Jinrong Li, Kunyang Li, Li Gu, Min Zheng, Jin Yuan, Hang Fan, Dongyan Deng, Yao Wang, Jianying Zhou

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Additional chemotherapy improves survival in stage II–III pulmonary sarcomatoid carcinoma patients undergoing surgery: a propensity scoring matching analysis

Yanhong Cen, Chunxu Yang, Jiangbo Ren, Yan Gong, Conghua Xie

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Poor consistency between reflux symptom index and laryngopharyngeal pH monitoring in laryngopharyngeal reflux diagnosis in Chinese population

Jun-Yao Wang, Tao Peng, Li-Li Zhao, Gui-Jian Feng, Yu-Lan Liu

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Elevated lipoprotein(a) and risk of coronary heart disease according to different lipid profiles in the general Chinese community population: the CHCN-BTH study

Chunyue Guo, Han Cao, Guangliang Shan, Wei Zhao, Han Zhang, Kaijun Niu, Ze Cui, Naijun Tang, Kuo Liu, Li Pan, Xiaoyan Han, Zhengfang Wang, Ge Meng, Jixin Sun, Anqi Shan, Yuxiang Yan, Huijing He, Zhiyuan Xu, Yajing Cao, Wenjuan Peng, Yanyan Sun, Yunyi Xie, Xiaohui Liu, Bingxiao Li, Fuyuan Wen, Ling Zhang

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Survey on uric acid in Chinese subjects with essential hypertension (SUCCESS): a nationwide cross-sectional study

Jing Liu, Luyuan Chen, Hong Yuan, Kai Huang, Guangping Li, Ningling Sun, Yong Huo, on behalf of the SUCCESS investigation group

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Higher plasma NT-proBNP levels correlate with syndrome of inappropriate antidiuretic hormone and poor prognosis in neurological patients

Qing-Ling Zeng, Wen-Tao He, Gang Yuan

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Macrophage-derived netrin-1 contributes to endometriosis- associated pain

Shaojie Ding, Xinyue Guo, Libo Zhu, Jianzhang Wang, Tiantian Li, Qin Yu, Xinmei Zhang

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No diffuse intrahepatic biliary stricture after ABO-incompatible adult living donor liver transplantation using tailored rituximab-based desensitization protocol

Koji Natsuda, Takahiro Murokawa, Kwang-Woong Lee, Kyung Chul Yoon, Suk Kyun Hong, Jeong-Moo Lee, Jae-Hyung Cho, Nam-Joon Yi, Kyung-Suk Suh

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Primary tumor surgery improves survival of cancer patients with synchronous solitary bone metastasis: a large population-based study

Wei Wu, Honghua Zhang, Zhong Fang, Feng Li

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Identification of a novel interplay between intestinal bacteria and metabolites in Chinese patients with IgA nephropathy via integrated microbiome and metabolome approaches

Hongwei Wu, Donge Tang, Fengping Zheng, Shanshan Li, Xinzhou Zhang, Lianghong Yin, Fanna Liu, Yong Dai

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Plasma cytokines interleukin-18 and C-X-C motif chemokine ligand 10 are indicative of the anti-programmed cell death protein-1 treatment response in lung cancer patients

Yida Wang, Hanxiao Chen, Tianzhuo Zhang, Xue Yang, Jia Zhong, Yuyan Wang, Yujia Chi, Meina Wu, Tongtong An, Jianjie Li, Xinghui Zhao, Zhi Dong, Ziping Wang, Jun Zhao, Minglei Zhuo, Jing Huang

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Efficacy of immune-checkpoint inhibitors in advanced non-small cell lung cancer patients with different metastases

Meng Qiao, Fei Zhou, Likun Hou, Xuefei Li, Chao Zhao, Tao Jiang, Guanghui Gao, Chunxia Su, Chunyan Wu, Shengxiang Ren, Caicun Zhou

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Anthropometric parameters and liver histology influence lipid metabolic changes in HCV chronic hepatitis on direct-acting antiviral treatment

Domenico Iossa, Martina Vitrone, Massimo Gagliardi, Erasmo Falco, Enrico Ragone, Rosa Zampino, Emanuele Durante-Mangoni

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Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients—a pilot clinical study

Angelos Karlas, Max Masthoff, Michael Kallmayer, Anne Helfen, Michail Bariotakis, Nikolina Alexia Fasoula, Michael Schäfers, Max Seidensticker, Hans-Henning Eckstein, Vasilis Ntziachristos, Moritz Wildgruber

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Predicting aggressive histopathological features in esophageal cancer with positron emission tomography using a deep convolutional neural network

Joe Chao-Yuan Yeh, Wei-Hsiang Yu, Cheng-Kun Yang, Ling-I Chien, Ko-Han Lin, Wen-Sheng Huang, Po-Kuei Hsu

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miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1

Wenliang Tan, Zhirong Lin, Xianqing Chen, Wenxin Li, Sicong Zhu, Yingcheng Wei, Liyun Huo, Yajin Chen, Changzhen Shang

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Surface-treated 3D printed Ti-6Al-4V scaffolds with enhanced bone regeneration performance: an in vivo study

Guangdao Zhang, Pengyu Zhao, Lin Lin, Limei Qin, Zhiguang Huan, Sander Leeflang, Amir A. Zadpoor, Jie Zhou, Lin Wu

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Bone mineral density, osteopenia, osteoporosis, and fracture risk in patients with atopic dermatitis: a systematic review and meta- analysis

Di Wu, Xiang-Dong Wu, Xi Zhou, Wei Huang, Changqi Luo, Yong Liu

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Predictive factors of postoperative pancreatic fistula after laparoscopic pancreatoduodenectomy

Jikuan Jin, Guangbing Xiong, Jiali Li, Xingjun Guo, Min Wang, Zhen Li, Feng Zhu, Renyi Qin

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CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis

Weidong Shi, Chenyue Zhang, Zhouyu Ning, Yongqiang Hua, Ye Li, Lianyu Chen, Luming Liu, Zhen Chen, Zhiqiang Meng

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Automatic prediction of treatment outcomes in patients with diabetic macular edema using ensemble machine learning

Baoyi Liu, Bin Zhang, Yijun Hu, Dan Cao, Dawei Yang, Qiaowei Wu, Yu Hu, Jingwen Yang, Qingsheng Peng, Manqing Huang, Pingting Zhong, Xinran Dong, Songfu Feng, Tao Li, Haotian Lin, Hongmin Cai, Xiaohong Yang, Honghua Yu

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Clinical findings in a group of COVID-19 patients: a single-center retrospective study

Fang Ji, Liang Wang, Chunyang Li, Liping Wang, Jungui Hao, Mingjia Dai, Yan Liu, Xiucheng Pan, Juanjuan Fu, Li Li, Guangde Yang, Jianye Yang, Xiao Zhang, Jiachuan Wang, Renhao Wang, Xuebing Yan, Bing Gu

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Roles of NANOGP8 in cancer metastasis and cancer stem cell invasion during development of castration-resistant prostate cancer

Yi Sui, Wei Zhang, Rujian Zhu, Lili Gao, Ting Cao, Chuhong Chen, Min Gong, Hongbo Zhu, Tao Tang, Bo Yu, Tao Yang

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Diagnosis and management of protracted bacterial bronchitis: a survey of Chinese pediatricians

Qinyuan Li, Ziyao Guo, Yuanyuan Li, Guangli Zhang, Xiaoyin Tian, Ruixue Gu, Zhengxiu Luo

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Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer

Xi Chen, Yuan-Liang Yan, Shuang-Shuang Zeng, Zhi-Cheng Gong, Zhi-Jie Xu

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Risk factors of regional lymph node (RLN) metastasis among patients with bone sarcoma and survival of patients with RLN-positive bone sarcoma

Yimin Dong, Wei Wu, Honglei Kang, Wei Xiong, Dawei Ye, Zhong Fang, Hanfeng Guan, Hui Liao, Feng Li

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Impact of anesthesia methods on perioperative systemic inflammation and long-term outcomes in patients undergoing surgery for hepatocellular carcinoma: a propensity score-matched analysis

Hao Zhang, Kefang Guo, Xingfeng Sun, Yi Liu, Ziwen Zhong, Wenchang Zhou, Weian Zeng, Lu Wang, Juan P. Cata, Wankun Chen, Changhong Miao

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Endoscopic ultrasound efficacy in staging gastric linitis plastica lesion: a retrospective multicentric French study

Stephanie Morgant, Pascal Artru, Ammar Oudjit, Nelson Lourenco, Arnaud Pasquer, Thomas Walter, Jean-Marc Gornet, Alexandre Rouquette, Catherine Brezault, Romain Coriat

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A multi-center study of prediction of macular hole status after vitrectomy and internal limiting membrane peeling by a deep learning model

Yijun Hu, Yu Xiao, Wuxiu Quan, Bin Zhang, Yuqing Wu, Qiaowei Wu, Baoyi Liu, Xiaomin Zeng, Ying Fang, Yu Hu, Songfu Feng, Ling Yuan, Tao Li, Hongmin Cai, Honghua Yu

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Identification of crucial genes mediating abdominal aortic aneurysm pathogenesis based on gene expression profiling of perivascular adipose tissue by WGCNA

Siliang Chen, Dan Yang, Bao Liu, Yuexin Chen, We Ye, Mengyin Chen, Yuehong Zheng

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Sex-specific survival benefit in early skin melanoma based on 8th AJCC edition: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) database

Ran Mo, Chen Chen, Yanan Jiang, Zhouji Ma, Xueyong Meng, Qian Tan

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A novel prognostic nomogram for patients with surgically resected perihilar cholangiocarcinoma: a SEER-based study

Pengfei Li, Lujun Song

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Hepatobiliary phase hypointensity on gadobenate dimeglumine- enhanced magnetic resonance imaging may improve the diagnosis of hepatocellular carcinoma

Yueming Li, Jianwei Chen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Liting Wen, Dairong Cao, Jinsheng Hong

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The predictive prognostic values of serum interleukin-2, interleukin-6, interleukin-8, tumor necrosis factor-α, and procalcitonin in surgical intensive care unit patients

Yamin Yan, Yan Hu, Xiaorong Wang, Zhenghong Yu, Yingjia Tang, Yuxia Zhang, Wenyan Pan

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The effects of TGF-β1 on staphylococcus epidermidis biofilm formation in a tree shrew biomaterial-centered infection model

Yujie Lei, Yushan Xu, Peng Jing, Bingquan Xiang, Keda Che, Junting Shen, Minjie Ning, Ying Chen, Yunchao Huang

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Profiles of alternative splicing landscape in breast cancer and their clinical significance: an integrative analysis based on large-sequencing data

Jun-Xian Du, Yong-Lei Liu, Gui-Qi Zhu, Yi-Hong Luo, Cong Chen, Cheng-Zhe Cai, Si-Jia Zhang, Biao Wang, Jia-Liang Cai, Jian Zhou, Jia Fan, Zhi Dai, Wei Zhu

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N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular carcinoma

Shen Shen, Jingya Yan, Yize Zhang, Zihui Dong, Jiyuan Xing, Yuting He

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Quadrangular resection versus chordal replacement for degenerative posterior mitral leaflet prolapse

Jiexu Ma, Jian Liu, Peijian Wei, Ximeng Yao, Yuyuan Zhang, Liangzheng Fang, Zhao Chen, Yanjun Liu, Tong Tan, Hongxiang Wu, Huanlei Huang, Bin Xie, Jimei Chen, Jian Zhuang, Huiming Guo

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Incision and flap design during total auricular reconstruction using a 2-stage strategy

Yangxue Ou, Tongyu Cao, Qingguo Zhang, Tun Liu

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Clinical manifestations of blood cell parameters and inflammatory factors in 92 patients with COVID-19

Rongrong Deng, Changzheng Wang, Yi Ye, Liyao Gou, Zhongxiao Fu, Bo Ye, Feng Shao, Xiaomei Zhang, Weiyang Fu, Jianping Xiao, Tao Li, Huan Qi, Chengbin Li

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Temporal dynamic changes of intrinsic brain activity in Alzheimer’s disease and mild cognitive impairment patients: a resting-state functional magnetic resonance imaging study

Ting Li, Zhengluan Liao, Yanping Mao, Jiaojiao Hu, Dansheng Le, Yangliu Pei, Wangdi Sun, Jixin Lin, Yaju Qiu, Junpeng Zhu, Yan Chen, Chang Qi, Xiangming Ye, Heng Su, Enyan Yu

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EEG power spectral analysis reveals tandospirone improves anxiety symptoms in patients with Alzheimer’s disease: a prospective cohort study

Zhengluan Liao, Xiaoyu Zhao, Ting Li, Yanping Mao, Jiaojiao Hu, Dansheng Le, Yangliu Pei, Yan Chen, Yaju Qiu, Junpeng Zhu, Jixin Lin, Heng Su, Linju Zhang, Enyan Yu

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Disrupted balance of long and short-range functional connectivity density in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) patients: a resting-state fMRI study

Yanping Mao, Zhengluan Liao, Xiaozheng Liu, Ting Li, Jiaojiao Hu, Dansheng Le, Yangliu Pei, Wangdi Sun, Jixin Lin, Yaju Qiu, Junpeng Zhu, Yan Chen, Chang Qi, Heng Su, Enyan Yu

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Review Article

A narrative review of the roles of the miR-15/107 family in heart disease: lessons and prospects for heart disease

Manni Zheng, Min Wang

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A narrative review of machine learning as promising revolution in clinical practice of scoliosis

Kai Chen, Xiao Zhai, Kaiqiang Sun, Haojue Wang, Changwei Yang, Ming Li

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A narrative review of central nervous system involvement in acute leukemias

Dalma Deak, Nicolae Gorcea-Andronic, Valentina Sas, Patric Teodorescu, Catalin Constantinescu, Sabina Iluta, Sergiu Pasca, Ionut Hotea, Cristina Turcas, Vlad Moisoiu, Alina-Andreea Zimta, Simona Galdean, Jakob Steinheber, Ioana Rus, Sebastian Rauch, Cedric Richlitzki, Raluca Munteanu, Ancuta Jurj, Bobe Petrushev, Cristina Selicean, Mirela Marian, Olga Soritau, Alexandra Andries, Andrei Roman, Delia Dima, Alina Tanase, Olafur Sigurjonsson, Ciprian Tomuleasa

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A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management

Zhi Zheng, Yi-Xuan Ding, Yuan-Xu Qu, Feng Cao, Fei Li

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Stem cell secretome, regeneration, and clinical translation: a narrative review

Chukwuweike Gwam, Nequesha Mohammed, Xue Ma

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The reliability of adductor tubercle as an anatomical landmark for joint line restoration in revision knee arthroplasty: a systematic review

Berardo Di Matteo, Daniele Altomare, Andrea Dorotei, Giovanni Francesco Raspugli, Tommaso Bonanzinga, Maurilio Marcacci, Elizaveta Kon, Francesco Iacono

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A narrative review of risk factors and interventions for cancer- related cognitive impairment

Lu Bai, Enyan Yu

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Study Protocol

A phase III study on neoadjuvant chemotherapy versus neoadjuvant toripalimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma: Henan Cancer Hospital Thoracic Oncology Group 1909 (HCHTOG1909)

Yan Zheng, Xian-Ben Liu, Hai-Bo Sun, Jinliang Xu, Sining Shen, Yu-Feng Ba, Ming Yan, Zimin Qin, Bao-Xing Liu, Zong-Fei Wang, Shi-Lei Liu, Rui-Xiang Zhang, Pei-Nan Chen, Guang-Hui Liang, Dongfeng Yuan, Zhen-Xuan Li, Qi Liu, Hao-Ran Wang, Hao-Miao Li, Hongwei Lv, Xiaochao Ma, Jianping Zhu, Yong-Kui Yu, Wen-Qun Xing, written on Henan Cancer Hospital Thoracic Oncology Group (HCHTOG)

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iMDT Corner¹

Pulmonary angiosarcoma presenting with diffuse alveolar hemorrhage: a case report

Min Yu, Weibin Huang, Yan Wang, Guangsuo Wang, Lingwei Wang, Weihua Tao, Saadia A. Faiz, Fung Him Ng, Huiping Li

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Case Report

A rare case of an unexpected difficult airway management in a diffuse idiopathic skeletal hyperostosis patient and post-operative airway evaluation with 3D printing technique

Xiaoqing Zhang, Jun Wang, Yajie Liu, Zhengqian Li, Bin Han

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Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report

Carolina Dagli-Hernandez, Renata Caroline Costa de Freitas, Elisangela da Silva Rodrigues Marçal, Rodrigo Marques Gonçalves, Andre Arpad Faludi, Jéssica Bassani Borges, Gisele Medeiros Bastos, Bruna Los, Augusto Akira Mori, Raul Hernandes Bortolin, Glaucio Monteiro Ferreira, Victor Fernandes de Oliveira, Thiago Dominguez Crespo Hirata, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata

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A rare case of primary pulmonary inflammatory pseudotumor-like follicular dendritic cell sarcoma successfully treated by lobectomy

Huayu He, Qi Xue, Fengwei Tan, Lin Yang, Xin Wang, Yushun Gao, Yousheng Mao, Juwei Mu, Dali Wang, Jun Zhao, Liang Zhao, Shugeng Gao

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A case report of membranous occlusion of the subclavian vein: a rare cause of McCleery syndrome

Jingjing Yin, Zhenhong Qi, Yu Chen, Yuexin Chen

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Atypical hemolytic uremic syndrome after childbirth: a case report

Hong Sang Choi, Jae Won Yun, Hee-Jin Kim, Doyeun Oh, Nah Ihm Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae

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The emergence of various genetic alterations mediated the Osimertinib resistance of a patient harboring heterozygous germline EGFR T790M: a case report

Bin Liu, Jianwen Qin, Yan Yin, Liang Zhai, Guangxin Liu, Analyn Lizaso, Dongsheng Shi

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Changes in cognitive function and related brain regions in chronic benzene poisoning: a case report

Jiaojiao Hu, Enyan Yu, Zhengluan Liao

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Letter to the Editor

Predictive value of neutrophil-leucocyte in cardiac surgery

Weimin Zhang, Xuandong Jiang

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Editorial on Current State of Intraoperative Imaging²

Editorial for current state of intraoperative imaging in spinal surgery

Sheeraz Qureshi

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Review Article on Current State of Intraoperative Imaging²

Intraoperative risks of radiation exposure for the surgeon and patient

Nathaniel W. Jenkins, James M. Parrish, Evan D. Sheha, Kern Singh

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Current state of navigation in spine surgery

Nathaniel Rawicki, James E. Dowdell, Harvinder S. Sandhu

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The current state of navigation in robotic spine surgery

Meng Huang, Tyler A. Tetreault, Avani Vaishnav, Philip J. York, Blake N. Staub

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Preoperative planning for intraoperative navigation guidance

Shahbaaz A. Sabri, Philip J. York

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Narrative review of intraoperative imaging guidance for decompression-only surgery

Sohrab Virk, Sheeraz Qureshi

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Narrative review of intraoperative image guidance for transforaminal lumbar interbody fusion

Joseph A. Weiner, Michael H. McCarthy, Peter Swiatek, Philip K. Louie, Sheeraz A. Qureshi

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Intraoperative image guidance for lateral position surgery

Peter R. Swiatek, Michael H. McCarthy, Joseph Weiner, Shivani Bhargava, Avani S. Vaishnav, Sravisht Iyer

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Intraoperative image guidance for the surgical treatment of adult spinal deformity

Venkat Boddapati, Joseph M. Lombardi, Hikari Urakawa, Ronald A. Lehman

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Intraoperative image guidance for endoscopic spine surgery

Jason I. Liounakos, Gregory W. Basil, Hikari Urakawa, Michael Y. Wang

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Intraoperative image guidance for cervical spine surgery

Sertac Kirnaz, Harry Gebhard, Taylor Wong, Raj Nangunoori, Franziska Anna Schmidt, Kosuke Sato, Roger Härtl

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Current innovation in virtual and augmented reality in spine surgery

Frank J. Yuk, Georgios A. Maragkos, Kosuke Sato, Jeremy Steinberger

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Erratum

Erratum to aberrant amplitude low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in generalized anxiety disorder (GAD) and their roles in predicting treatment remission

Editor Team

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Erratum to comprehensive bioinformatics analysis of the TP53 signaling pathway in Wilms’ tumor

Changjing He, Huatao Qin, Haizhou Tang, Di Yang, Yufeng Li, Zhenwen Huang, Donghu Zhang, Changheng Lv

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Disclosure:

1. The series “iMDT Corner” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding.

2. The series “Current State of Intraoperative Imaging” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Sheeraz Qureshi served as the unpaid Guest Editor for the series.

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Diagnostic electrophysiological study in a highly trained young woman with presyncopal symptoms during exercise: a case report

Fernando de la Guía-Galipienso, Fabian Sanchis-Gomar, Aurelio Quesada-Dorador

Pulmonary vein stenosis after lung transplantation: a case report and literature review

Lei Jing, Wenhui Chen, Zhenguo Zhai, Xin Pan, Xincao Tao, Lei Cao, Li Zhao, Lijuan Guo, Chaoyang Liang, Jingyu Chen, Chen Wang

Identifying familial hypercholesterolemia in an early onset ischemic cerebrovascular disease patient and the cascade screening in the pedigree: a case report

Yuan Yuan, Xiaoyan Zhao, Xiangyun Teng, Yunfeng Zhang

Bosworth-type fibular entrapment fracture of the ankle without dislocation: a rare case report and a review of the literature

Sang-Jin Han, Jong-Heon Kim, Du-Bin Yang, Boo-Seop Kim, Hyun-Soo Ok

Endoscopy during neurotomy of the nervus intermedius for nervus intermedius neuralgia: a case report

Zhuhuan Song, Jian Chen, Jianhong Shen, Zhongzheng Jia, Qinwei Wang, Shichen Jiang, Xide Xu, Wei Shi

Editorial

Editorial for the series on pain therapy

Antonio Ruggiero

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

Esophageal surgery in the 21^st century

Ory Wiesel

Hyperthermic intrathoracic chemotherapy (HITHOC) should be included in the guidelines for malignant pleural mesothelioma

Marcello Migliore, Michael Ried, Laureano Molins, Marco Lucchi, Marcello Ambrogi, Tamas F. Molnar, Hans-Stefan Hofmann

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

SPECTnet: a deep learning neural network for SPECT image reconstruction

Wenyi Shao, Steven P. Rowe, Yong Du

Coronary artery disease: differential expression of ceRNAs and interaction analyses

Sheng Kang, Yong Ye, Guang Xia, Hai-Bo Liu

The role of primary tumor SUVmax in the diagnosis of invasion depth: a step toward clinical T2N0 esophageal cancer

Dong Lin, Guobing Liu, Dongxian Jiang, Yangli Yu, Hao Wang, Hongcheng Shi, Lijie Tan

Kiaa0101 serves as a prognostic marker and promotes invasion by regulating p38/snail1 pathway in glioma

Junhui Liu, Lun Gao, Jianmin Liao, Ji’an Yang, Fan’en Yuan, Qianxue Chen

Clinical characteristics, inflammation and coagulation status in patients with immunological disease-related chronic cerebrospinal venous insufficiency

Si-Ying Song, Duo Lan, Xiao-Qin Wu, Yu-Chuan Ding, Xun-Ming Ji, Ran Meng

Endarterectomy versus stenting for the prevention of periprocedural stroke or death in patients with symptomatic or asymptomatic carotid stenosis: a meta-analysis of 10 randomized trialsWenqiang Xin, Shixue Yang, Qifeng Li, Xinyu Yang

Wenqiang Xin, Shixue Yang, Qifeng Li, Xinyu Yang

The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review

Dong Lin, Xiaosang Chen, Lijie Tan

A nomogram for the predicting of survival in patients with esophageal squamous cell carcinoma undergoing definitive chemoradiotherapy

Peiliang Wang, Maoqi Yang, Xin Wang, Zongxing Zhao, Minghuan Li, Jinming Yu

Alteration of spatial patterns at the network-level in facial synkinesis: An independent component and connectome analysis

Zhen-Zhen Ma, Ye-Chen Lu, Jia-Jia Wu, Si-Si Li, Wei Ding, Jian-Guang Xu

Maternally expressed 3 protects the intestinal barrier from cardiac arrest-induced ischemia/reperfusion injury via miR-34a-3p/sirtuin 1/nuclear factor kappa B signaling

Xianwei Huang, Mandong Pan, Penghui Du, Yinrong Chen, Caixia Zhang, Wang Lu, Jiyan Lin

Risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections: a nationwide population-based study

Seon Cheol Park, Sun Young Won, Na Hye Kim, Heun Choi, Tae Mi Youk, Hyun Jung Lee, Han Ho Jeon

Deep learning for differentiating novel coronavirus pneumonia and influenza pneumonia

Min Zhou, Dexiang Yang, Yong Chen, Yanping Xu, Jin-Fu Xu, Zhijun Jie, Weiwu Yao, Xiaoyan Jin, Zilai Pan, Jingwen Tan, Lan Wang, Yihan Xia, Longkuan Zou, Xin Xu, Jingqi Wei, Mingxin Guan, Fuhua Yan, Jianxing Feng, Huan Zhang, Jieming Qu

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Intravenous fluids for pain management in head and neck cancer patients undergoing chemoradiation

Charlotte I. Rivers, Austin J. Iovoli, Udit Chatterjee, Gregory M. Hermann, Anurag K. Singh

Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes

Christoph Knappich, Thomas Lang, Pavlos Tsantilas, Sofie Schmid, Michael Kallmayer, Bernhard Haller, Hans-Henning Eckstein

Markers of muscle damage and strength performance in professional football (soccer) players during the competitive period

Vladimir Khaitin, Eduard Bezuglov, Artemii Lazarev, Sergey Matveev, Olga Ivanova, Nicola Maffulli, Evgeny Achkasov

Detection of SARS-CoV-2 in the ocular surface in different phases of COVID-19 patients in Shanghai, China

Meiyan Li, Yaling Yang, Taiwen He, Ruoyan Wei, Yinzhong Shen, Tangkai Qi, Tian Han, Zhigang Song, Zhaoqin Zhu, Xiaopeng Ma, Jing Zhao, Yixiao Lin, Yang Shen, Weiming Yang, Keqing Zhao, Hongzhou Lu, Xingtao Zhou

Comparison of capecitabine-based regimens with platinum-based regimens in Chinese triple-negative breast cancer patients with liver metastasis

Yimeng Chen, Yin Guan, Jiayu Wang, Fei Ma, Yang Luo, Shanshan Chen, Pin Zhang, Qing Li, Ruigang Cai, Qiao Li, Hongnan Mo, Ying Fan, Weihong Zhao, Binghe Xu

Genitalia-related nursing embarrassment and its associated factors among female nurses in mainland China: a nationwide cross-sectional study

Guoyi Yang, Huixin Liu, Jia Wang, Zixian Geng, Ling Wang, Tao Xu

Fractional heat shock protein 27 urine excretion as a short-term predictor in acute exacerbation of chronic obstructive pulmonary disease

Denise Traxler, Matthias Zimmermann, Elisabeth Simader, Elisa Einwallner, Dragan Copic, Alexandra Graf, Thomas Mueller, Cecilia Veraar, Mitja Lainscak, Robert Marčun, Mitja Košnik, Matjaž Fležar, Aleš Rozman, Peter Korošec, Walter Klepetko, Bernhard Moser, Hendrik J. Ankersmit

Predicting subretinal fluid absorption with machine learning in patients with central serous chorioretinopathy

Fabao Xu, Yifan Xiang, Cheng Wan, Qijing You, Lijun Zhou, Cong Li, Songjian Gong, Yajun Gong, Longhui Li, Zhongwen Li, Li Zhang, Xiayin Zhang, Chong Guo, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Chenjin Jin, Haotian Lin

A comparison of the inflammatory response following autologous compared with allogenic islet cell transplantation

Wen Yuan Chung, Cristina A. Pollard, Rohan Kumar, Christopher J. Drogemuller, Bashoo Naziruddin, Cordula Stover, Eyad Issa, John Isherwood, Jill Cooke, Marlon F. Levy, P. Toby H. Coates, Giuseppe Garcea, Ashley R. Dennison

Correlation between apparent diffusion coefficient and pathological characteristics of patients with invasive breast cancer

Yuhui Chen, Jiandong Wang, Xiuxiu Zhang, Wuyao Yang, Hongye Chen, Baoshi Bao, Yue Qiu, Lin Tian

MiR-29c-3p inhibits epithelial-mesenchymal transition to inhibit the proliferation, invasion and metastasis of cervical cancer cells by targeting SPARC

Ting Zou, Yan Gao, Mingrong Qie

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Perception of femininity and attractiveness in Facial Feminization Surgery

Ann Hui Ching, Allister Hirschman, Xiaona Lu, Seija Maniskas, Antonio J. Forte, Michael Alperovich, John A. Persing

A comparison of perioperative safety for breast augmentation in cis- vs. trans patients

Kyle S. Gabrick, Fouad Chouiari, Kitae E. Park, Omar Allam, Mohammed Ali Mozaffari, John A. Persing, Michael Alperovich

Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration

Un Chul Park, Susanna S. Park, Bo Hee Kim, Sung Wook Park, Young Joo Kim, Whitney Cary, Johnathon D. Anderson, Jan A. Nolta, Hyeong Gon Yu

Relationship between intraoperative measured parameters of parathyroid gland and pathological patterns in patients with secondary hyperparathyroidism

Xiaoliang Sun, Xiaoqing Zhang, Ling Zhang, Meng Yang, Yao Lu

Analysis of the autoimmune response against BP180 in patients with Alzheimer’s disease

Ya-Nan Wang, Christoph M. Hammers, Xuming Mao, Hong-Zhong Jin, Jing Yuan, Li Li

SLC6A8 is involved in the progression of non-small cell lung cancer through the Notch signaling pathway

Yan Feng, Xiangyu Guo, Huaping Tang

Albumin-bilirubin index and platelet-albumin-bilirubin index contribute to identifying survival benefit candidates in patients with hepatocellular carcinoma and Child-Pugh grade A undergoing transcatheter arterial chemoembolization with sorafenib treatment

Keshu Hu, Jia Yuan, Bei Tang, Feng Zhang, Shenxin Lu, Rongxin Chen, Lan Zhang, Zhenggang Ren, Xin Yin

Predicting the cumulative number of disaster deaths during the early stage of earthquakes

Marie Fujimoto, Hiroshi Nishiura

Functional differences and similarities in activated peripheral blood mononuclear cells by lipopolysaccharide or phytohemagglutinin stimulation between human and cynomolgus monkeys

Zhi Lin, Ying Huang, Hua Jiang, Di Zhang, Yanwei Yang, Xingchao Geng, Bo Li

Fracture mapping of complex intra-articular calcaneal fractures

Ming Ni, Miko Lin Lv, Wanju Sun, Yingqi Zhang, Jiong Mei, Duo Wai-Chi Wong, Haowei Zhang, Yongwei Jia, Ming Zhang

Variables in the Danish Hernia Databases: inguinal and ventral

Jacob Rosenberg, Hans Friis-Andersen, Lars Nannestad Jørgensen, Kristoffer Andresen

A novel artificial intelligence-assisted triage tool to aid in the diagnosis of suspected COVID-19 pneumonia cases in fever clinics

Cong Feng, Lili Wang, Xin Chen, Yongzhi Zhai, Feng Zhu, Hua Chen, Yingchan Wang, Xiangzheng Su, Sai Huang, Lin Tian, Weixiu Zhu, Wenzheng Sun, Liping Zhang, Qingru Han, Juan Zhang, Fei Pan, Li Chen, Zhihong Zhu, Hongju Xiao, Yu Liu, Gang Liu, Wei Chen, Tanshi Li

Associations of hand washing frequency with the incidence of illness: a systematic review and meta-analysis

Yangqin Xun, Qingxia Shi, Nan Yang, Nan Yang, Yan Li, Wenwen Si, Qianling Shi, Zijun Wang, Xia Liu, Xuan Yu, Qi Zhou, Minyan Yang, Yaolong Chen

Oral atenolol treatment for infantile hemangiomas: clinical analysis of 133 consecutive patients

Ze-Liang Zhao, Chao Liu, Qi-Zhang Wang, Hai-Wei Wu, Jia-Wei Zheng

Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study

Chongxiang Chen, Qiaozhen Hu, Jiaojiao Wang, Tianmeng Wen, Chaoyang Zhu, Weiyan Tan, Xuelin Chen, Qingyu Zhao, Wei Wang, Huijiao Cao, Huan Li

Effects of notoginseng leaf triterpenes on small molecule metabolism after cerebral ischemia/reperfusion injury assessed using MALDI–MS imaging

Lei Wang, Ting Zhu, Hui-Bo Xu, Xiao-Ping Pu, Xin Zhao, Fang Tian, Tao Ding, Gui-Bo Sun, Xiao-Bo Sun

A biomarker-based age, biomarkers, clinical history, sex (ABCS)-mortality risk score for patients with coronavirus disease 2019

Meng Jiang, Changli Li, Li Zheng, Wenzhi Lv, Zhigang He, Xinwu Cui, Christoph F. Dietrich

An enhanced level of LAMP-2A participates in CD4⁺T cell hyperactivity in patients with primary biliary cholangitis

Keshuai Sun, Shuoyi Ma, Siyuan Tian, Miao Zhang, Yansheng Liu, Bo Li, Xia Zhou, Xiaohong Zheng, Xinmin Zhou, Lu Wang, Ying Han

A cohort study of hepatectomy-related complications and prediction model for postoperative liver failure after major liver resection in 1,441 patients without obstructive jaundice

Bin Li, Yingyi Qin, Zhiquan Qiu, Jun Ji, Xiaoqing Jiang

The effect of primary site, functional status and treatment modality on survival in gastroenteropancreatic neuroendocrine neoplasms with synchronous liver metastasis: a US population-based study

Ning Pu, Joseph R. Habib, Michael Bejjani, Hanlin Yin, Minako Nagai, Jianan Chen, Benedict Kinny-Köster, Qiangda Chen, Jicheng Zhang, Jun Yu, Wenchuan Wu, Wenhui Lou

Development and validation of a risk stratification model for predicting the mortality of acute kidney injury in critical care patients

Haofan Huang, Yong Liu, Ming Wu, Yi Gao, Xiaxia Yu

Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells

Lanlin Hu, Yutong Liang, Kelv Wu, Caixia Wang, Tao Zhang, Rui Peng, Fangdong Zou

Association of apnea-hypopnea index during rapid eye movement sleep with insulin resistance in patients with suspected obstructive sleep apnea: a cross-sectional study

Juanjuan Zou, Yupu Liu, Huajun Xu, Lili Meng, Jianyin Zou, Yingjun Qian, Bin Chen, Hongliang Yi, Jian Guan, Shankai Yin

Single versus two-stage phalloplasty for transgender female-to-male patients: a systematic review of the literature

Maria T. Huayllani, Daniel Boczar, Humza Y. Saleem, Gabriela Cinotto, Francisco R. Avila, Oscar J. Manrique, Pedro Ciudad, Brian D. Rinker, Antonio J. Forte

Pyrotinib versus trastuzumab emtansine for HER2-positive metastatic breast cancer after previous trastuzumab and lapatinib treatment: a real-world study

Feng Li, Fengrui Xu, Jianbin Li, Tao Wang, Li Bian, Shaohua Zhang, Zefei Jiang

Mechanisms underlying pro-arrhythmic abnormalities arising from Pitx2-induced electrical remodelling: an in silico intersubject variability study

Yijie Zhu, Jieyun Bai, Andy Lo, Yaosheng Lu, Jichao Zhao

The predictive value of urinary kidney injury molecular-1 for long-term graft function in kidney transplant patients: a prospective study

Minyan Zhu, Zhejun Chen, Yuehan Wei, Yanhong Yuan, Liang Ying, Hang Zhou, Xiajing Che, Min Fang Zhang, Zhaohui Ni, Ming Zhang, Shan Mou

The usefulness of intraoperative consultation for the diagnosis of borderline ovarian tumors

Rosa A. Salcedo-Hernández, David F. Cantú-de-León, Delia Pérez-Montiel, Leticia García-Pérez, Leonardo S. Lino-Silva, César Zepeda-Najar, Salim A. Barquet-Muñoz

Upgraded nomograms for the prediction of complications and survival in patients with colorectal liver metastases treated with neoadjuvant chemotherapy followed by hepatic resection

Qichen Chen, Rui Mao, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Hong Zhao, Jianqiang Cai

Comparison of the visual performance between Oculentis MF30 and Tecnis ZMB00 multifocal intraocular lenses

Lingying Ye, Tianyu Chen, Zhixiang Hu, Qingwen Yang, Qiudong Su, Jin Li

Clinicopathological characteristics and prognostic factors of pulmonary sarcomatoid carcinoma: a large population analysis

Jin Gang, Qiao Yan, Song Xiang, Li Zheng, Lujun Zhao

Comparative proteomics analysis for identifying the lipid metabolism related pathways in patients with Klippel-Feil syndrome

Ziquan Li, Cong Zhang, Bintao Qiu, Yuchen Niu, Ling Leng, Siyi Cai, Ye Tian, Terry Jianguo Zhang, Guixing Qiu, Nan Wu, Zhihong Wu, Yipeng Wang

Clinical characteristics and HLA genotypes in Chinese patients with anti-SLA/LP-positive autoimmune hepatitis

Hai-Ping Zhang, Yan-Min Liu, Zhao Li, Yin-Xue Ma, Li-Juan Li, Dan-Tong Zhao, Jin-Li Lou, Zu-Hua Gao, Hui-Ping Yan

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A. Nolta, Susanna S. Park

The value of lactate/albumin ratio for predicting the clinical outcomes of critically ill patients with heart failure

Wenqin Guo, Lingyue Zhao, Hanjun Zhao, Fanfang Zeng, Changnong Peng, Wenyu Guo, Hongbing Yan

Elongated axial length and myopia-related fundus changes associated with the Arg130Cys mutation in the LIM2 gene in four Chinese families with congenital cataracts

Xun Wang, Yanli Qin, Aierxiding Abudoukeremuahong, Meimei Dongye, Xulin Zhang, Dongni Wang, Jing Li, Zhuoling Lin, Yahan Yang, Lin Ding, Haotian Lin

Survival analysis of second primary malignancies after cervical cancer using a competing risk model: implications for prevention and surveillance

Runmei Li, Yue Zhang, Bingqing Ma, Kangming Tan, Henry S. Lynn, Zhenyu Wu

Effectiveness and safety of insulin glargine Gla-300 in insulin-naïve type 2 diabetes subjects in a real-life setting—the GOAL_RO trial

Daniela Stegaru, Simona Nicodim, Delia Vladu, Olimpia Guțu, Adriana Onaca, Florina Pîrvu, Mihaela Moise, Cristian Guja, for the GOAL_RO Study Group

Selective right middle and lower lobar blockade for minimally invasive cardiac surgery: a prospective, single-center, randomized controlled study

Yun Ren, Yi Lyu, Ying Yu, Lin Jin, Yan Hu, Kefang Guo, Jing Cang

RNA-binding protein QKI suppresses breast cancer via RASA1/MAPK signaling pathway

Yun Cao, Chengyu Chu, Xiaoyan Li, Siwen Gu, Qiang Zou, Yiting Jin

Impact of different therapies on the survival of patients with stage I–IIA cervical cancer with intermediate risk factors

Jichan Nie, Qinjiao Wu, Anqi Yan, Zhiyong Wu

Bioelectrical impedance analysis for predicting postoperative complications and survival after liver resection for hepatocellular carcinoma

Gil Ho Lee, Hyo Jung Cho, Garam Lee, Han Gyeol Kim, Hee Jung Wang, Bong-Wan Kim, Mi Young Lee, So Young Yoon, Choong-Kyun Noh, Chul Won Seo, Jung Woo Eun, Jae Youn Cheong, Sung Won Cho, Soon Sun Kim

Post hoc analysis of two clinical trials to compare the immunogenicity and safety of different polio immunization schedules in Chinese infants

Ting Zhao, Zhaojun Mo, Zhifang Ying, Teng Huang, Yanchun Che, Guoliang Li, Xiaolei Yang, Mingbo Sun, Li Jiang, Li Shi, Hui Ye, Zhimei Zhao, Xiaochang Liu, Jing Li, Yanping Li, Rongcheng Li, Ruiju Jiang, Jianfeng Wang, Yuting Fu, Rufei Ma, Hongyuan Shi, Huan Yang, Changgui Li, Jingsi Yang, Qihan Li

Systemic immune-inflammation index: a prognostic tiebreaker among all in advanced pancreatic cancer

Alessandro Bittoni, Federica Pecci, Giulia Mentrasti, Sonia Crocetti, Alessio Lupi, Andrea Lanese, Chiara Pellei, Chiara Ciotti, Luca Cantini, Riccardo Giampieri, Edoardo Lenci, Enrica Giglio, Federica Bini, Cecilia Copparoni, Tania Meletani, Maria Giuditta Baleani, Rossana Berardi

A novel prophylactic Chinese parachute ankle brace

Xi Zhou, Di Wu, Xiangdong Wu, Zhengyao Li, Bin Yan, Leilei Liang, Yu He, Yong Liu

Regulation of smooth muscle contractility by the epithelium in rat tracheas: role of prostaglandin E2 induced by the neurotransmitter acetylcholine

Lei Zhao, Yu-Ting Liang, Dong-Bo Tian, Rui-Gang Zhang, Jiehong Huang, Yun-Xin Zhu, Wen-Liang Zhou, Yi-Lin Zhang

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Association of a novel PKHD1 mutation in a family with autosomal dominant polycystic liver disease

Jiaru Wang, Huayu Yang, Ruohan Guo, Xinting Sang, Yilei Mao

Gender differences of relationship between serum lipid indices and type 2 diabetes mellitus: a cross-sectional survey in Chinese elderly adults

Xiao-Wei Ji, Guo-Shan Feng, Hong-Lan Li, Jie Fang, Jing Wang, Qiu-Ming Shen, Li-Hua Han, Da-Ke Liu, Yong-Bing Xiang

Co-existence of myopia and amblyopia in a guinea pig model with monocular form deprivation

Lu Tian, Ya-Tu Guo, Ming Ying, Yang-Chen Liu, Xuan Li, Yan Wang

The effects of UCP2 on autophagy through the AMPK signaling pathway in septic cardiomyopathy and the underlying mechanism

Jia-Yu Mao, Long-Xiang Su, Dong-Kai Li, Hong-Min Zhang, Xiao-Ting Wang, Da-Wei Liu

Artificial intelligence-based myocardial texture analysis in etiological differentiation of left ventricular hypertrophy

Fei Yu, Haibo Huang, Qihui Yu, Yuqing Ma, Qi Zhang, Bo Zhang

Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2

Ruojing Wang, Jing Chen, Fan Ding, Lin Zhang, Xuan Wu, Yi Wan, Jianying Hu, Xiaoyan Zhang, Qing Wu

Distinctive genomic characteristics in POLE/POLD1-mutant cancers can potentially predict beneficial clinical outcomes in patients who receive immune checkpoint inhibitor

Junjun He, Wei Ouyang, Wugan Zhao, Lin Shao, Bing Li, Bihao Liu, Dejuan Wang, Han Han-Zhang, Zhou Zhang, Liang Shao, Wencai Li

Molecular profiling of Chinese systemic anaplastic large cell lymphoma patients: novel evidence of genetic heterogeneity

Li-Hua Zhong, Zhi-Da Wu, Jian-Chao Wang, Zai-Zeng Wu, Fang-Fang Chen, Wei-Feng Zhu, Yan-Ping Chen, Gang Chen

Vimentin regulation of autophagy activation in lung fibroblasts in response to lipopolysaccharide exposure in vitro

Pan Pan, Longxiang Su, Xiaoting Wang, Wenzhao Chai, Dawei Liu, Licheng Song, Lixin Xie

Development and validation of magnetic resonance imaging- based radiomics models for preoperative prediction of microsatellite instability in rectal cancer

Wei Zhang, Zixing Huang, Jian Zhao, Du He, Mou Li, Hongkun Yin, Song Tian, Huiling Zhang, Bin Song

Investigating the protective effect of tanshinone IIA against chondrocyte dedifferentiation: a combined molecular biology and network pharmacology approach

Yushen Zhang, Liguo Sun, Xincheng Liu, Dongze Zhu, Jingyi Dang, Yingsen Xue, Hongbin Fan

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Immune profiling and immunotherapeutic targets in pancreatic cancer

Felicia L. Lenzo, Shumei Kato, Sarabjot Pabla, Paul DePietro, Mary K. Nesline, Jeffrey M. Conroy, Blake Burgher, Sean T. Glenn, Boris Kuvshinoff, Razelle Kurzrock, Carl Morrison

Trends in conditional overall survival of esophageal cancer: a population-based study

Wei Deng, Zhao Yang, Xin Dong, Rong Yu, Weihu Wang

The role of magnification correction in macular vessel density assessment: a contralateral eye study in anisometropia patients

Dan Fu, Meiyan Li, Li Zeng, Jianmin Shang, Zhiqiang Yu, Xingtao Zhou

Clinical outcomes following surgical mitral valve repair or replacement in patients with rheumatic heart disease: a meta-analysis

Yefan Jiang, Chen Wang, Geng Li, Si Chen

Compliance with the Surviving Sepsis Campaign guideline 1-hour bundle for septic shock in China in 2018

Lu Wang, Xudong Ma, Huaiwu He, Longxiang Su, Yanhong Guo, Guangliang Shan, Ye Wang, Xiang Zhou, Dawei Liu, Yun Long, China National Critical Care Quality Control Center Group

MET deletion is a frequent event in gastric/gastroesophageal junction/esophageal cancer: a cross-sectional analysis of gene status and signal distribution in 1,580 patients

Jan Trøst Jørgensen, Jens Mollerup, Hui Yang, Ning Go, Karsten Bork Nielsen

Review Article

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

The modern approach to esophageal palliative and emergency surgery

Anny Godin, Moishe Liberman

New frontiers in esophageal radiology

Eric J. Schmidlin, Ritu R. Gill

Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

Environmental triggers of dermatomyositis: a narrative review

Christina E. Bax, Spandana Maddukuri, Adarsh Ravishankar, Lisa Pappas-Taffer, Victoria P. Werth

Updates in pharmacotherapy of heart failure with reduced ejection fraction

Clifton Espinoza, Haider Alkhateeb, Tariq Siddiqui

The CLASI, a validated tool for the evaluation of skin disease in lupus erythematosus: a narrative review

Srita Chakka, Rebecca L. Krain, Josef Symon S. Concha, Benjamin F. Chong, Joseph F. Merola, Victoria P. Werth

Diagnostic management of nonalcoholic fatty liver disease: a transformational period in the development of diagnostic and predictive tools—a narrative review

Natalia Rosso, Adam M. Stephenson, Pablo J. Giraudi, Claudio Tiribelli

Revisiting hemochromatosis: genetic vs. phenotypic manifestations

Gregory J. Anderson, Edouard Bardou-Jacquet

Molecular landscape of head and neck cancer and implications for therapy

Camile S. Farah

Paraesophageal hernia: to fundoplicate or not?

Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan

Pulmonary vasodilator use in continuous-flow left ventricular assist device management

Preethi Pirlamarla, Eduardo Rame, Charles Hoopes, Indranee Rajapreyar

Administration of dry powders during respiratory supports

Wei-Ren Ke, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Patricia Tang, Lan Chen, Donghao Chen, Hak-Kim Chan

The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis—a narrative review article

Wolfgang Stremmel, Martina Lukasova, Ralf Weiskirchen

Non-alcoholic fatty liver diseases: current challenges and future directions

Elke Roeb

The dark side of immunotherapy

Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami

Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry

Renato Salvador, Mario Costantini, Salvatore Tolone, Pietro Familiari, Ermenegildo Galliani, Bastianello Germanà, Edoardo Savarino, Stefano Merigliano, Michele Valmasoni

Measurements of deposited aerosol dose in infants and small children

Timothy E. Corcoran

Inhaled pulmonary vasodilators: a narrative review

Kai Liu, Huan Wang, Shen-Ji Yu, Guo-Wei Tu, Zhe Luo

Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

Sangwan Park, Brian C. Leonard, Vijay Krishna Raghunathan, Soohyun Kim, Jennifer Y. Li, Mark J. Mannis, Christopher J. Murphy, Sara M. Thomasy

Gene therapy for inherited retinal diseases

Yan Nuzbrokh, Sara D. Ragi, Stephen H. Tsang

Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

Jeff Rytlewski, Mohammed M. Milhem, Varun Monga

Artificial intelligence in molecular imaging

Edward H. Herskovits

Evolving treatment paradigms in esophageal cancer

Ilit Turgeman, Irit Ben-Aharon

Pain assessment in clinical trials: a narrative review

Livia Puljak, Krste Boric, Svjetlana Dosenovic

Narrative review of pharmacotherapy for transthyretin cardiac amyloid

Jose B. Cruz Rodriguez, Jose A. Tallaj

Narrative review of intrathecal drug delivery (IDD): indications, devices and potential complications

Michele Antonio Capozza, Silvia Triarico, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero

Intranasal drugs for analgesia and sedation in children admitted to pediatric emergency department: a narrative review

Valeria Pansini, Antonietta Curatola, Antonio Gatto, Ilaria Lazzareschi, Antonio Ruggiero, Antonio Chiaretti

Human cutaneous B cells: what do we really know?

Irina Lerman, Drew C. Mitchell, Christopher T. Richardson

Narrative Review of Carotid disease and the kidney

Luca Zanoli, Dimitri P. Mikhailidis

Aerosol delivery via noninvasive ventilation: role of models and bioanalysis

Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mohamed E. A. Abdelrahim

De novo gastroesophageal reflux disease esophageal surgery in bariatrics: a literature review and analysis of the current treatment options

Rene Aleman, Emanuele Lo Menzo, Samuel Szomstein, Raul J. Rosenthal

A narrative review of malnutrition in chronic liver disease

Soan Shin, Dae Won Jun, Waqar Khalid Saeed, Dong Hee Koh

A narrative review of near-infrared fluorescence imaging in hepatectomy for hepatocellular carcinoma

Weiqi Zhang, Zhenhua Hu, Jie Tian, Chihua Fang

Fluorescence-guided surgery of the esophagus

Paul Chandler, Ory Wiesel, Danny A. Sherwinter

Fugitive aerosols in the intensive care unit: a narrative review

Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin

Endovascular embolization in renal trauma: a narrative review

Tyler Andrew Smith, Adriene Eastaway, Duncan Hartt, Keith Bertram Quencer

Optimal diuretic strategies in heart failure

Sarabjeet S. Suri, Salpy V. Pamboukian

Therapeutic strategies in Wilson disease: pathophysiology and mode of action

Wolfgang Stremmel, Ralf Weiskirchen

Targeting vascular endothelial growth factor using retinal gene therapy

Sook H. Chung, Sonia L. Frick, Glenn Yiu

Advances in the interventional management of neuropathic pain

Vishal Varshney, Jill Osborn, Rahul Chaturvedi, Vrajesh Shah, Krishnan Chakravarthy

A narrative review of prehypertension and the cardiovascular system: effects and potential pathogenic mechanisms

Lin Zhao, Xu Meng, Qiong-Yu Zhang, Xue-Qi Dong, Xian-Liang Zhou

The modern approach to esophagectomy—review of the shift towards minimally invasive surgery

Daniel P. Dolan, Scott J. Swanson

Robotics and minimally invasive esophageal surgery

Ealaf Shemmeri, Jon O. Wee

Inhaled antibiotics during mechanical ventilation—why it will work

Maxime Desgrouas, Stephan Ehrmann

Narrative review in the current role of angiotensin receptor-neprilysin inhibitors

Jose B. Cruz Rodriguez, Cameron Cu, Tariq Siddiqui

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Frank Tacke, Ralf Weiskirchen

Esophageal disease in lung transplant patients

John S. Young, Antonio Coppolino

The role of bile acids in cholestatic liver injury

Shi-Ying Cai, James L. Boyer

A graphical guide for constructing a finite element model of the cervical spine with digital orthopedic software

Weidong Wu, Zhihua Han, Bin Hu, Chun Du, Zehua Xing, Chao Zhang, Jianqing Gao, Bin Shan, Chun Chen

Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes

Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique

It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis

Amit Khurana, Nilofer Sayed, Prince Allawadhi, Ralf Weiskirchen

A path to successful patient outcomes through aerosol drug delivery to children: a narrative review

Arzu Ari

Dairy consumption and hepatocellular carcinoma risk

Bodo C. Melnik

Review of aerosol delivery in the emergency department

Patricia A. Dailey, Courtney M. Shockley

Dermatomyositis and malignancy: should all patients with dermatomyositis undergo malignancy screening?

Urmi Khanna, Fabrizio Galimberti, Yumeng Li, Anthony P. Fernandez

Surgical techniques of phalloplasty in transgender patients: a systematic review

Daniel Boczar, Maria T. Huayllani, Humza Y. Saleem, Gabriela Cinotto, Francisco R. Avila, Salam Kassis, Xiaona Lu, Brian D. Rinker, Antonio J. Forte

Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery

Luigi Bonavina

Opioid transdermal delivery system: a useful method for pain management in children

Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attinà, Palma Maurizi, Alberto Romano, Antonio Ruggiero

Narrative review: the holy grail: update on pharmacotherapy for heart failure with preserved ejection fraction

Pablo Alejandro Paz, Barbara Daniela Mantilla, Erwin E. Argueta, Debabrata Mukherjee

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

Rolf Teschke, Jack Uetrecht

Antiplatelet and anticoagulation strategies for left ventricular assist devices

Renzo Y. Loyaga-Rendon, Toshinobu Kazui, Deepak Acharya

Narrative review of vascular iatrogenic trauma and endovascular treatment

Tyler Andrew Smith, David Gage, Keith Bertram Quencer

Splenic trauma: endovascular treatment approach

Maxwell Cretcher, Catherine E. P. Panick, Alexander Boscanin, Khashayar Farsad

Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction

Vaia Florou, Sonam Puri, Ignacio Garrido-Laguna, Breelyn A. Wilky

Covert clues: the non-hallmark cutaneous manifestations of dermatomyositis

Rochelle L. Castillo, Alisa N. Femia

Polishing the crystal ball: mining multi-omics data in dermatomyositis

Rochelle L. Castillo, Alisa N. Femia

Consensus

2020 expert consensus statement on neuro-protection after cardiac arrest in China

Qingbian Ma, Liqun Feng, Tao Wang, Yongqiu Li, Zhenzhong Li, Bin Zhao, Xiuchuan Qin, Qingxi Li, Shizheng Wu, Hongbin Sun, Jun Yuan, Lan Chu, Jian Wu, Yuxiang Gu, Peter Pang, Zhi Chen, Dongsheng Fan, on behalf of the Brain and Vascular Branch & First Aid and Resuscitation Branch of the Chinese Society of Cardiothoracic and Vascular Anaesthesiology

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.