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Novel Tools and Therapies for Ocular Regeneration

This special series is very timely since there has been a recent increase in the momentum of translational research in ocular regeneration. This increase stems partially from the success of ocular gene therapy. This special eye series includes review and original articles of novel tools and therapies being developed for ocular regeneration. The goal of this eye series is to provide some overview of the latest research being done in the area of ocular regeneration in order to highlight the broad potential in this field.

Challenges in Clinical Trials (Ongoing)

This special series on “Challenges in Clinical Trials” is edited by Dr. Weiping Wen, Dr. Yanhong Deng, Dr. Qian Shi and Dr. Jun (Vivien) Yin. As with any industry, the challenges facing those working in clinical trials are numerous: from patient recruitment, adoption of technology, regulatory requirements, and spiraling costs. This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.

Carotid Artery Stenosis and Stroke-Prevention and Treatment Part II

Prevention and treatment of ischemic carotid-related strokes is a research priority. All controversial issues should be addressed to optimize patient outcomes. The current series are the second part of two series on the prevention and treatment of carotid artery stenosis and carotid-related strokes. Hopefully, these two series will help to answer many of the current questions and to resolve some of the controversial issues on the topic.

New Impact Factor for Annals of Translational Medicine: 3.932

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2020 citation year: 3.932.

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Reviewer of the Month (2021)

In 2021, ATM reviewers continue to make outstanding contributions to the peer review process. The following reviewers are highlighted and commended for their professional effort and enthusiasm in reviews. Let us take this chance to express our heartfelt gratitude for their tremendous effort and valuable contributions to the journal and to the scientific process!

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

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Vol 9, No 17 (September, 2021)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Evaluation of nodal status in intrahepatic cholangiocarcinoma: a population-based study

Xiaoyuan Chen, Dawei Rong, Long Zhang, Chuangye Ni, Guoyong Han, Yiwei Lu, Xuejiao Chen, Yun Gao, Xuehao Wang

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Inhibit inflammation and apoptosis of pyrroloquinoline on spinal cord injury in rat

Qiao Zhou, Hui Jin, Naiqi Shi, Shumei Gao, Xiaoyu Wang, Shunxing Zhu, Meijuan Yan

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Spindle and kinetochore-associated complex subunit 3 (SKA3) promotes stem cell-like properties of hepatocellular carcinoma cells through activating Notch signaling pathway

Shuya Bai, Wei Chen, Mengli Zheng, Xiju Wang, Wang Peng, Yuchong Zhao, Yun Wang, Si Xiong, Bin Cheng

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Hypoxia-preconditioned mesenchymal stem cells attenuate microglial pyroptosis after intracerebral hemorrhage

Jianyang Liu, Jialin He, Yan Huang, Lite Ge, Han Xiao, Liuwang Zeng, Zheng Jiang, Ming Lu, Zhiping Hu

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Effect of stroke screening survey on intravenous thrombolysis and long-term outcomes in acute ischemic stroke patients: the real- world evidence from Shanghai, China

Fen Li, Yuqian Chen, Lan Hong, Bifan Zhu, Duo Chen, Xinyu Qin, Guangfeng Gao, Jianhua Xu, Xin Cheng, Qiang Dong, Chunlin Jin, Kun Fang

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Three-dimensional fracture mapping of multi-fragmentary patella fractures (AO/OTA 34C3)

Yu Zhan, Yingqi Zhang, Xuetao Xie, Congfeng Luo

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Cost-effectiveness of combination antiviral treatment with extended duration for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B in China

Runqin Li, Xiao Lin, Jing-Yue Wang, Xiaomo Wang, Junfeng Lu, Yali Liu, Zhenhuan Cao, Shan Ren, Lina Ma, Yi Jin, Sujun Zheng, Zhongjie Hu, Li Wang, Xinyue Chen

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A novel efficient and precise technique for removing acetabular osteophytes in patients undergoing total hip arthroplasty: the SH-9Hospital acetabular edge file

Yongyun Chang, Keyu Kong, Yiming Zeng, Degang Yu, Jingwei Zhang, Mengning Yan, Yuanqing Mao, Huiwu Li, Zanjing Zhai

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Application of various surgical techniques in liver transplantation: a retrospective study

Zhitao Chen, Weiqiang Ju, Chuanbao Chen, Tielong Wang, Jia Yu, Xitao Hong, Yuqi Dong, Maogen Chen, Xiaoshun He

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LncRNA THRIL is involved in the proliferation, migration, and invasion of rheumatoid fibroblast-like synoviocytes

Yaoyao Zou, Chuyu Shen, Ting Shen, Jingnan Wang, Xuepei Zhang, Qian Zhang, Runlu Sun, Lie Dai, Hanshi Xu

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LncRNA FTX promotes the malignant progression of colorectal cancer by regulating the miR-214-5p–JAG1 axis

Luxiang Pan, Mingrui Du, Haixia Liu, Boyang Cheng, Maorong Zhu, Bo Jia, Yinwen Wang, Wei He, Xiaoju Li, Chenlin Liu, Jintao Gu, Meng Li, Yingqi Zhang, Li Yao, Yi Zhang, Qiang Hao

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Differences in artificial ligament graft osseointegration of the anterior cruciate ligament in a sheep model: a comparison between interference screw and cortical suspensory fixation

Hong Li, Fangyi Jiang, Yunsheng Ge, Fang Wan, Hongyun Li, Shiyi Chen

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Hemorrhagic stroke outcomes of KApSR patients with co-morbid diabetes and Alzheimer’s disease

Amanda L. Trout, Christopher J. McLouth, Patrick Kitzman, Michael R. Dobbs, Lisa Bellamy, Kelley Elkins, Justin F. Fraser

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Cancer gene related characterization of patterns and point of recurrence after resection of colorectal liver metastases

Hauke Lang, Janine Baumgart, Wilfried Roth, Markus Moehler, Michael Kloth

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Neutrophil extracellular trap formation index predicts occurrences of deep surgical site infection after laparotomy

Zehua Duan, Shilong Sun, Cheng Qu, Kai Wang, Fang Chen, Xinyu Wang, Chengnan Chu, Baochen Liu, Jieshou Li, Weiwei Ding

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MiR-552-3p promotes malignant progression of gallbladder carcinoma by reactivating the Akt/β-catenin signaling pathway due to inhibition of the tumor suppressor gene RGMA

Fengliang Song, Zhao Yang, Liang Li, Yanping Wei, Xuewu Tang, Shuowu Liu, Miao Yu, Jin Chen, Suyang Wang, Jingbo Fu, Kecheng Zhang, Pinghua Yang, Xinwei Yang, Zhong Chen, Baohua Zhang, Hongyang Wang

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Second primary malignancies associated with radiation therapy in cervical cancer patients diagnosed between 1975 and 2011: a population-based competing-risk study

Yijun Wu, Yuming Chong, Chang Han, Kai Kang, Zhikai Liu, Fuquan Zhang

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TNF-α-stimulated nucleus pulposus cells induce cell apoptosis through the release of exosomal miR-16 targeting IGF-1 and IGF-1R in rats

Qi-Chen Zhang, Yan-Pei Zou, Shun-Qi Hu, Tai-Wei Zhang, Hao Zhou, Bing Liang, Chen-Yang Zhuang, Hui-Ren Wang, Li-Bo Jiang, Xi-Lei Li

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Effect of pyrroloquinoline quinone on lipopolysaccharide-induced autophagy in HAPI microglia cells

Shumei Gao, Qiao Zhou, Hui Jin, Naiqi Shi, Xiaoyu Wang, Li Zhang, Meijuan Yan

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ACY1 regulating PTEN/PI3K/AKT signaling in the promotion of non-small cell lung cancer progression

Hong Chen, Wei Wang, Caizhi Xiao, Dongqin Xia, Fangfei Li, Shaoyong Liu

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Artesunate attenuates foam cell formation by enhancing cholesterol efflux

Yan Qian, Li Xia, Lai Wei, Weiwei Jiang

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Phosphoproteomics identifies potential downstream targets of the integrin α2β1 inhibitor BTT-3033 in prostate stromal cells

Bingsheng Li, Pan Li, Weiping Xia, Baiyang You, Qingfeng Yu, Bo Zhang, Ru Huang, Ruixiao Wang, Yuhan Liu, Zhi Chen, Yu Gan, Yao He, Martin Hennenberg, Christian G. Stief, Xiang Chen

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Dipetidyl peptidase-4 and transferrin receptor serve as prognostic biomarkers for acute myeloid leukemia

Jie Wei, Guan Ye Nai, Yi Dai, Xun Jun Huang, Ming Yue Xiong, Xiang You Yao, Zhi Ning Huang, Si Nian Li, Wei Jie Zhou, Yan Huang, Peng Cheng, Dong Hong Deng

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Analysis of the expression profile of serum exosomal lncRNA in breast cancer patients

Xin Zhao, Xuhui Guo, Dechuang Jiao, Jiujun Zhu, Hui Xiao, Yue Yang, Shengnan Zhao, Jingyang Zhang, Feifei Jiao, Zhenzhen Liu

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Comprehensive analysis of lncRNA and miRNA expression profiles and ceRNA network construction in negative pressure wound therapy

Jie Wu, Yong Qin, Zhirui Li, Jiantao Li, Litao Li, Sheng Tao, Daohong Liu

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Triptolide inhibits neutrophil extracellular trap formation

Haiyu Guan, Lifen Xie, Zhenzhen Ji, Rui Song, Jieying Qi, Xiaoli Nie

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Transcription factor EB mediates oxidative stress-induced intervertebral disc degeneration via the NF-κB signaling pathway

He Liang, Zhou Liu, Yunhao Wang, Deguo Wang, Jiwei Tian

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Key immune-related gene ITGB2 as a prognostic signature for acute myeloid leukemia

Jie Wei, Xun-Jun Huang, Yan Huang, Ming-Yue Xiong, Xiang-You Yao, Zhi-Ning Huang, Si-Nian Li, Wei-Jie Zhou, Da-Lang Fang, Dong-Hong Deng, Peng Cheng

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LncRNA KCNQ1OT1 promoted hepatitis C virus-induced pyroptosis of β-cell through mediating the miR-223-3p/NLRP3 axis

Ben Niu, Lixuan Yao, Yating Zhang, Xueshan Xia, Heng Su

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Distribution of the population and health projects of the Joint Fund in China between 2006 and 2019

Hongmei Zhou, Xiaoqiu Yang, Quan Liu, Jun Pu, Rong Lei

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Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor

En-Qi Qiao, Hong-Jian Yang, Xing-Fei Yu, Li-Jie Gong, Xi-Ping Zhang, Dao-Bao Chen

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Diagnostic performance of CT-derived resting distal to aortic pressure ratio (resting Pd/Pa) vs. CT-derived fractional flow reserve (CT-FFR) in coronary lesion severity assessment

Quan Li, Yang Zhang, Chunliang Wang, Shiming Dong, Yijin Mao, Yida Tang, Yong Zeng

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Downregulation of FEM1C enhances metastasis and proliferation in colorectal cancer

Runqing Huang, Jianxia Li, Yang Fu, Yanhong Deng

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LAMC2 promotes the proliferation of cancer cells and induce infiltration of macrophages in non-small cell lung cancer

Meiyuan Liu, Rui Cai, Tian Wang, Xia Yang, Meng Wang, Zhongsheng Kuang, Yuhui Xie, Jiren Zhang, Yanfang Zheng

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Review Article

Experimental animal models of drug-induced sensorineural hearing loss: a narrative review

Xuexin Lin, Jia Luo, Jingqian Tan, Luoying Yang, Mitian Wang, Peng Li

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Wilson disease and the differential diagnosis of its hepatic manifestations: a narrative review of clinical, laboratory, and liver histological features

Shannon M. Schroeder, Karen E. Matsukuma, Valentina Medici

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Study Protocol

The BYPASS-CTCA Study: the value of Computed Tomography Cardiac Angiography (CTCA) in improving patient-related outcomes in patients with previous bypass operation undergoing invasive coronary angiography: Study Protocol of a Randomised Controlled Trial

Anne-Marie Beirne, Krishnaraj S. Rathod, Emily Castle, Mervyn Andiapen, Amy Richards, Anna Bellin, Victoria Hammond, Thomas Godec, James C. Moon, Ceri Davies, Christos V. Bourantas, Andrew Wragg, Amrita Ahluwalia, Francesca Pugliese, Anthony Mathur, Daniel A. Jones

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Retraction

Retraction to using a deep recurrent neural network with EEG signal to detect Parkinson’s disease

Shixiao Xu, Zhihua Wang, Jutao Sun, Zhiqiang Zhang, Zhaoyun Wu, Tiezhao Yang, Gang Xue, Chuance Cheng

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Olaparib effectively treats local recurrence of extrahepatic cholangiocarcinoma in a patient harboring a BRCA2-inactivating mutation: a case report

Wenxin Li, Zuohong Ma, Xibo Fu, Zhiqiang Hao, Hai Shang, Junping Shi, Mengping Lei, Mian Xu, Shili Ning, Xiangdong Hua

Homozygous deletion of the HLA-B gene as an acquired-resistance mechanism to nivolumab in a patient with lung adenocarcinoma: a case report

He Zhang, Weiwei Dong, Huixia Zhao, Zhiyan Zeng, Fengyun Zhang, Yanyan Hu, Qiuwen Li, Jing Chen, Erhong Meng, Wenhua Xiao

An unusual presentation of acute deep vein thrombosis after the Moderna COVID-19 vaccine—a case report

Chandur Bhan, Nimarta Bheesham, Fnu Shakuntulla, Monica Sharma, Chenyu Sun, Mitchell Weinstein

Clinical pharmacist participation in selecting and dosing targeted drugs for a patient with ALK-positive non-small cell lung cancer: a case report

Caifu Fang, Tao Liu, Weiting Liang, Shiyin Feng, Zhiqiang Su, Hongmei Tang, Hongbing Huang, Zhuojia Chen

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Correlation of PIK3CA mutation with programmed death ligand-1 (PD-L1) expression and their clinicopathological significance in colorectal cancer

Ae Ri Ahn, Kyoung Min Kim, Kyu Yun Jang, Woo Sung Moon, Gi Won Ha, Min Ro Lee, Myoung Ja Chung

Recognizing blood pressure patterns in sedated critically ill patients on mechanical ventilation by spectral clustering

Shengjun Liu, Longxiang Su, Xin Liu, Xueqian Zhang, Zuyu Chen, Chun Liu, Na Hong, Yali Li, Yun Long

Kv3.1 channelopathy: a novel loss-of-function variant and the mechanistic basis of its clinical phenotypes

Xiaoyang Li, Yongsheng Zheng, Shaoyuan Li, Umesh Nair, Chong Sun, Chongbo Zhao, Jiahong Lu, Victor Wei Zhang, Snezana Maljevic, Steven Petrou, Jie Lin

The important roles and molecular mechanisms of annexin A₂ autoantibody in children with nephrotic syndrome

Qing Ye, Yingying Zhang, Jieqiu Zhuang, Ye Bi, Hong Xu, Qian Shen, Jialu Liu, Haidong Fu, Jingjing Wang, Chunyue Feng, Xiaoxiao Tang, Fei Liu, Weizhong Gu, Fei Zhao, Jianjiang Zhang, Yuanhan Qin, Shiqiang Shang, Hongqiang Shen, Xuejun Chen, Huijun Shen, Aimin Liu, Yonghui Xia, Zhihong Lu, Qiang Shu, Jianhua Mao

CALD1 promotes the expression of PD-L1 in bladder cancer via the JAK/STAT signaling pathway

Cheng Li, Fuhan Yang, Ruiliang Wang, Wei Li, Niraj Maskey, Wentao Zhang, Yadong Guo, Shenghua Liu, Hong Wang, Xudong Yao

Expression of tiRNA and tRF in APP/PS1 transgenic mice and the change of related proteins expression

Honglin Lu, Lin Liu, Shu Han, Binbin Wang, Jin Qin, Kailin Bu, Yingzhen Zhang, Zhongzhong Li, Lina Ma, Jing Tian, Kun Zhang, Tong Li, Huixian Cui, Xiaoyun Liu

Randomized controlled trial of acupuncture for anxiety and depression in patients with chronic insomnia

Chenyong Liu, Yanan Zhao, Shan Qin, Xiaoqiu Wang, Yuanyuan Jiang, Wenzhong Wu

Hypoglycemia following the use of glucagon-like peptide-1 receptor agonists: a real-world analysis of post-marketing surveillance data

Zhe Zhao, Yan Tang, Yang Hu, Huijuan Zhu, Xiaoguang Chen, Bin Zhao

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

The clinical value of valve metagenomic next-generation sequencing when applied to the etiological diagnosis of infective endocarditis

Sishi Cai, Ye Yang, Jue Pan, Qing Miao, Wenting Jin, Yuyan Ma, Chunmei Zhou, Xiaodong Gao, Chunsheng Wang, Bijie Hu

Circulating S100A4 as a prognostic biomarker for patients with nonparoxysmal atrial fibrillation after catheter ablation

Lijun Qian, Jinlong Gong, Wenjie Ma, Yan Sun, Jian Hong, Di Xu, Ming Chu

Comparative healing of swine skin following incisions with different surgical devices

Yuting Zhong, Yufan Wei, Ningning Min, Qingyu Guan, Jin Zhao, Junyong Zhu, Huayu Hu, Rui Geng, Chenyan Hong, Yashuang Ji, Jie Li, Yiqiong Zheng, Yanjun Zhang, Xiru Li

Development and evaluation of an early death risk prediction model after acute type A aortic dissection

Yuhui Zhang, Tongyun Chen, Qingliang Chen, Hou Min, Jiang Nan, Zhigang Guo

The clinical value of serum hepatic parenchyma cell volume-normalized hepatitis B surface antigen levels in hepatitis B e antigen -positive and -negative chronic hepatitis B patients

Lei Tan, Shi-Lei Xu, Zhi-Shuo Mo, Jian-Rong Liu, Wei-Qiang Gan, Jie-Huan Chen, Zhi-Liang Gao, Ze-Qian Wu

Correlation of m6A methylation with immune infiltrates and poor prognosis in non-small cell lung cancer via a comprehensive analysis of RNA expression profiles

Bo Dong, Chunli Wu, Shi-Hao Li, Lan Huang, Chunyang Zhang, Bin Wu, Yinliang Sheng, Yafei Liu, Guanchao Ye, Yu Qi

Propofol protects hippocampal neurons in sleep-deprived rats by inhibiting mitophagy and autophagy

Weixin Dai, Yong Xiao, Youbing Tu, Fei Xiao, Yizhi Lu, Yinying Qin, Yubo Xie

ACSL4 contributes to sevoflurane-induced ferroptotic neuronal death in SH-SY5Y cells via the 5' AMP-activated protein kinase/ mammalian target of rapamycin pathway

Lei Cheng, Xiaodan Zhu, Yang Liu, Kai Zhu, Kang Lin, Fujun Li

SULF2 is a novel diagnostic and prognostic marker for high-grade bladder cancer with lymphatic metastasis

Jianhua Huang, Cheng Li, Wentao Zhang, Fuhan Yang, Ruiliang Wang, Junfeng Zhang, Wei Li, Xudong Yao

Retrospective validation of 11–13 weeks’ gestation ultrasound characteristics as predictive tools for twin-twin transfusion syndrome and selective intrauterine growth restriction in monochorionic diamniotic twin pregnancies

Yin-Di Zhu, Jin-Yan Bian, Yu-Ping Liao, Ting Hu, Ming-Yue Wang, You-Guo Chen, Mei-Fang Pan, Xin-Xian Gu

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Interaction between hepatitis B virus infection and the efficacy of camrelizumab in combination with apatinib therapy in patients with hepatocellular carcinoma: a multicenter retrospective cohort study

Guosheng Yuan, Rong Li, Qi Li, Xiaoyun Hu, Jian Ruan, Wenzhe Fan, Junjie Wang, Wei Huang, Mengya Zang, Jinzhang Chen

Identifying unmet non-COVID-19 health needs during the COVID-19 outbreak based on social media data: a proof-of-concept study in Wuhan city

Wei-Fa Yang, Danping Zheng, Reynold C. K. Cheng, Jingya Jane Pu, Yu-Xiong Su

Classification and immune invasion analysis of breast cancer based on m6A genes

Qiang Qin, Da Lang Fang, Weijie Zhou, Yuhua Meng, Jie Wei

3D-printed personalised prostheses for bone defect repair and reconstruction following resection of metacarpal giant cell tumours

Lin Xu, Hao Qin, Zhilin Cheng, Wen-Bo Jiang, Jia Tan, Xiang Luo, Wenhua Huang

Identification of key genes in cutaneous squamous cell carcinoma: a transcriptome sequencing and bioinformatics profiling study

Dan-Dan Zou, Dan Xu, Yuan-Yuan Deng, Wen-Juan Wu, Juan Zhang, Ling Huang, Li He

Novel nucleic acid aptamer gold (Au)-nanoparticles (AuNPs-AptHLA-G5-1 and AuNPs-AptHLA-G5-2) to detect the soluble human leukocyte antigen G5 subtype (HLA-G5) in liquid samples

Tao Su, Hui Wang, Yuanqing Yao

An integrated analysis of DNA promoter methylation, microRNA regulation, and gene expression in gastric adenocarcinoma

Hongyun Huang, Lang Xie, Xiaoxuan Feng, Zheng Zheng, Juntao Ouyang, Yan Li, Jinlong Yu

A novel immune-related ceRNA network that predicts prognosis and immunotherapy response in lung adenocarcinoma

Wei-Jing Gong, Tao Zhou, San-Lan Wu, Yi-Fei Huang, Li-Ping Xiang, Jia-Qiang Xu, Yong Han, Yong-Ning Lv, Yu Zhang, Fang Zeng

Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans

Jianhua Li, Jingfeng Zhong, Chunfa Huang, Jiewen Guo, Bingyu Wang

Quantitative assessment of crystal dissolution in gout during urate-lowering therapy with computer-aided MicroPure imaging: a cohort study

Qiao Wang, Hui Bao, Le-Hang Guo, Feng-Shan Jin, Xiao-Long Li, Hao-Hao Yin, Wen-Wen Yue, An-Qi Zhu, Li-Fan Wang, Li-Ping Sun, Hui-Xiong Xu

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Identification of the distinctive role of DPT in dilated cardiomyopathy: a study based on bulk and single-cell transcriptomic analysis

Yang Lu, Qiongfeng Wu, Jie Liao, Shaoshao Zhang, Kai Lu, Shuaitao Yang, Yuwei Wu, Qian Dong, Jing Yuan, Ning Zhao, Yimei Du

MRI-based three-dimensional reconstruction for staging cervical cancer and predicting high-risk patients

Jingjing Zhang, Yingteng Wang, Dongyan Cao, Keng Shen

Treatment burden of robotic gastrectomy for locally advanced gastric cancer (LAGC): a single western experience

M. Juanita Rodriguez, Ana Sofia Ore, Khoschy Schawkat, Kevin Kennedy, Andrea Bullock, Douglas K. Pleskow, Jonathan Critchlow, A. James Moser

Evaluation of reporting quality in clinical practice guidelines for acute myeloid leukemia using the RIGHT checklist

Ding Li, Cheng Cheng, Ziming Wang, Yi Zhang, Dongbei Li, Wenping Song, Baoxia He, Xuan Wu, Wenzhou Zhang

Comparison of treatments for hepatocellular carcinoma patients with portal vein thrombosis: a systematic review and network meta-analysis

Jianchen Luo, Liangliang Xu, Lian Li, Jingfu Zhang, Ming Zhang, Mingqing Xu

Shaping ability of four single-file systems in the instrumentation of second mesiobuccal canals of three-dimensional printed maxillary first molars

Fulu Xu, Yuerong Zhang, Yongchun Gu, Yifan Ping, Ruyu Zhou, Juan Wang

Preliminary study of the use of E6/E7mRNA detection in screening and triage management of HR-HPV infection during pregnancy

Yong-Mei Yang, Shi-Jun Wang, Feng-Ying Wang, Rui Chen, Qun Xiao, Ning Kang, Qing-Ping Liao

Acoustic features as novel predictors of difficult laryngoscopy in orthognathic surgery: an observational study

Ming Xia, Shuang Cao, Ren Zhou, Jia-Yi Wang, Tian-Yi Xu, Zhi-Kai Zhou, Yan-Min Qian, Hong Jiang

Identification of potential biomarkers in ovarian carcinoma and an evaluation of their prognostic value

Junyan Cai, Jiayi Qiu, Hongliang Wang, Jiacheng Sun, Yanan Ji

Phospho-EGFRTyr992 is synergistically repressed by co-inhibition of histone deacetylase (HDAC) and phosphatidylinositol 3-kinase (PI3K), which attenuates resistance to erlotinib in head and neck cancer cells

Xuejun Chen, Wen Gao, Gaofei Yin, Wei Guo, Junwei Huang, Zhigang Huang, Yang Zhang

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

A comparative analysis of gallbladder torsion and acute gallbladder disease without torsion: a single-center retrospective case series study

Woo Young Nho, Jong Kun Kim, Se Kook Kee

Safflower yellow pigment and Sanqi Panax notoginseng in the treatment of acute cerebral infarction: a systematic review, meta-analysis, and cost-effectiveness analysis

Yang Li, Yan Lin, Zhixiang Shi, Yuxuan Hu, Taihang Shao, Mengyuan Li, Jiawen Zhu, Lizhou Sun, Feng Chang

Entity relation extraction from electronic medical records based on improved annotation rules and BiLSTM-CRF

Tingyin Chen, Yongmei Hu

Risk factors of continuous renal replacement therapy following total aortic arch replacement under moderate hypothermia

Bo Li, Qing-Liang Chen, Bo-Chen Yao, Nan Jiang, Feng Zhao, Min Ren, Jing Sun, Li-Na Xu, Zhi-Gang Guo

Mechanism of action of resolvin D1 in inhibiting the progression of aortic dissection in mice

Bo Li, Bo-Chen Yao, Zhi-Gang Guo, Shao-Peng Zhang, Yan-Qiu Song, Nan Jiang, Xiao-Zhong Ma, Qing-Liang Chen

Analysis of whole-exome data of cfDNA and the tumor tissue of non-small cell lung cancer

Yuanzhou Wu, Qunqing Chen, Qiangzu Zhang, Man Li, Hui Li, Longfei Jia, Yang Huang, Jian Zhang

Protective effect of ultrasound microbubble combined with gross saponins of tribulus terrestris on glaucomatous optic nerve damage

Xiaoli Shen, Junhong Guo, Ning Fan, Mingying Lai, Lina Huang, Jiantao Wang, Qiang Li

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Prognostic nomogram for predicting long-term survival in bronchopulmonary carcinoid tumor patients receiving resection

Qiao Li, Qichen Chen, Jinghua Chen, Zijing Wang, Pan Wang, Hong Zhao, Jun Zhao

Aberrant miRNA-mRNA regulatory network in polycystic ovary syndrome is associated with markers of insulin sensitivity and inflammation

Yulan Qin, Yuhuan Wang, Hui Zhao, Zhaoxia Yang, Yani Kang

Development of nomograms related to inflammatory biomarkers to estimate the prognosis of bladder cancer after radical cystectomy

Wentao Zhang, Fuhan Yang, Aimaitiaji Kadier, Yifan Chen, Yang Yu, Junfeng Zhang, Jiang Geng, Yang Yan, Wei Li, Xudong Yao

Combined transcriptomic and lipidomic analysis of D-4F ameliorating bleomycin-induced pulmonary fibrosis

Yong Xia, Mei Cheng, Yanyan Hu, Man Li, Lin Shen, Xiang Ji, Xiaopei Cui, Xiangju Liu, Weiling Wang, Haiqing Gao

Extrachromosomal circular DNAs are common and functional in esophageal squamous cell carcinoma

Zhenguo Sun, Na Ji, Renchang Zhao, Jinghui Liang, Jin Jiang, Hui Tian

Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis

Nana Li, Lingxiao Qiu, Cheng Zeng, Zeming Fang, Shanshan Chen, Xiangjin Song, Heng Song, Guojun Zhang

Establishment and evaluation of a compound fear behavior model of Tourette’s syndrome in rats

Qian Chu, Anran Song, Run Zhao, Jianmin Liu, Huishan Shi, Pulin Liu, Chengda Dong, Zhaojun Yan

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

CCR2 and PTPRC are regulators of tumor microenvironment and potential prognostic biomarkers of lung adenocarcinoma

Jie Wei, Dalang Fang, Weijie Zhou

Comparison of severe and critical COVID-19 patients imported from Russia with and without influenza A infection in Heilongjiang Province: a retrospective study

Qingqing Dai, Ming Ye, Zhiqiang Tang, Kaijiang Yu, Yang Gao, Zhenyu Yang, Junbo Zheng, Shu Zuo, Yan Liu, Fengjie Xie, Qiuyuan Han, Hua He, Hongliang Wang

Functional assessment of a novel COL4A5 splicing site variant in a Chinese X-linked Alport syndrome family

Xiaolei Chen, Nan Ye, Lu Zhang, Wen Zheng, Jingqiu Cheng, Meng Gong

Role of spindle pole body component 25 in neurodegeneration

Feilun Cui, Zhipeng Xu, Yumei Lv, Jianpeng Hu

Wogonoside inhibits TNF receptor-associated factor 6 (TRAF6) mediated-tumor microenvironment and prognosis of pancreatic cancer

Hui Huang, Xia Li, Li Yu, Ling Liu, Hongwei Zhu, Wei Cao, Zhongling Sun, Xiao Yu

miR-155 regulates pro- and anti-inflammatory cytokine expression in human monocytes during chronic hepatitis C virus infection

Yun Zhou, Peixin Zhang, Xuyang Zheng, Chuantao Ye, Mengyuan Li, Peiyu Bian, Chao Fan, Ying Zhang

Cost-effectiveness of pembrolizumab versus docetaxel as second-line treatment of non-small cell lung cancer in China

Yafei Shi, Wei Chen, Yujun Zhang, Mingming Bo, Chunyu Li, Mingyu Zhang, Guohui Li

BMAL1 attenuates intracerebral hemorrhage-induced secondary brain injury in rats by regulating the Nrf2 signaling pathway

Yan Gong, Guoguo Zhang, Bing Li, Cheng Cao, Demao Cao, Xiang Li, Haiying Li, Ming Ye, Haitao Shen, Gang Chen

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

A modified algebraic reconstruction algorithm for sparse projection

Hongyan Li, Zhonglin Wan

A multidimensional nomogram combining imaging features and clinical factors to predict the invasiveness and metastasis of combined hepatocellular cholangiocarcinoma

Yi Wang, Chang-Wu Zhou, Gui-Qi Zhu, Na Li, Xian-Ling Qian, Huan-Huan Chong, Chun Yang, Meng-Su Zeng

FK506-loaded PLGA nanoparticles improve long-term survival of a vascularized composite allograft in a murine model

Zheming Cao, Cheng Li, Jiqiang He, Xinlei Sui, Panfeng Wu, Ding Pan, Liming Qing, Juyu Tang

Preoperative serum albumin: a promising indicator of early mortality after surgery for infective endocarditis

Suiqing Huang, Zhuoming Zhou, Li Luo, Yuan Yue, Quan Liu, Kangni Feng, Jian Hou, Keke Wang, Jiantao Chen, Huayang Li, Lin Huang, Guangguo Fu, Guangxian Chen, Mengya Liang, Zhongkai Wu

MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 and IRAK1 in human umbilical vein endothelial cells (HUVECs)

Jingyuan Hou, Qiaoting Deng, Xunwei Deng, Wei Zhong, Sudong Liu, Zhixiong Zhong

The prevalence and risk factors of potentially inappropriate medication use in older Chinese inpatients with multimorbidity and polypharmacy: a cross-sectional study

Fangyuan Tian, Shili Liao, Zhaoyan Chen, Ting Xu

Effects of voriconazole on population pharmacokinetics and optimization of the initial dose of tacrolimus in children with chronic granulomatous disease undergoing hematopoietic stem cell transplantation

Xiao Chen, Dongdong Wang, Jianger Lan, Guangfei Wang, Lin Zhu, Xiaoyong Xu, Xiaowen Zhai, Hong Xu, Zhiping Li

MiR-29c inhibits the metastasis of oral squamous cell carcinoma and promotes its cell cycle arrest by targeting SERPINH1

Chuanning Wang, Zhiming Wang, Liping Zhang, Xiaoping Lin

Atezolizumab compared to chemotherapy for first-line treatment in non-small cell lung cancer with high PD-L1 expression: a cost-effectiveness analysis from US and Chinese perspectives

Shuqiao Cheng, Rui Pei, Jianhuang Li, Bin Li, Lanhua Tang, Tao Yin, Shao Liu

Neuroprotective effects of novel compound Tozan on cognition, neurogenesis and apoptosis in diabetes

Su-Su Tang, Shu-Yun Xing, Xue-Jiao Zhang, Xiao-Qian Ren, Hao Hong, Yan Long

Review Article

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Mitochondrial bioenergetics and D-ribose in HFpEF: a brief narrative review

Kathryn J. Krueger, Faith K. Rahman, Qiuhua Shen, James Vacek, John B. Hiebert, Janet D. Pierce

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis

Jiayu Li, Qi Wang, Honghao Wang

Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review

Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu

Mechanisms and pharmacological applications of ferroptosis: a narrative review

Jing-Jing Zhang, Jing Du, Ni Kong, Guang-Yu Zhang, Meng-Zhen Liu, Chong Liu

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Reflections from a NMOSD case with serum AQP4-Ab negativity but CSF positivity: narrative review of how to interpret AQP4-Ab test results

Qun Xue, Shugang Cao, Qianyun Rui

Exosomes—a potential indicator and mediator of cleft lip and palate: a narrative review

Meng Chen, Yue Xie, Yarui Luo, Yimin Xie, Na Wu, Shulei Peng, Qiang Chen

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology

Weihua Zhang, Haitao Ren, Xiaotun Ren, Fang Fang, Hongzhi Guan

Circular RNAs as potential regulators in bone remodeling: a narrative review

Xuefeng Pan, Xiao Cen, Bo Zhang, Fang Pei, Wei Huang, Xinqi Huang, Zhihe Zhao

Erratum

Erratum to STAT1-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model

Editorial Office

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Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.