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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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Endorsement
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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

The impact of autostereoscopic screens on assessing depth perception
Robert W. Arnold
Annals of Translational Medicine
 2022;
10
(12)
:653
Deep-learning algorithms for choroidal thickness measurements in high myopia
Francisco de Asís Bartol-Puyal, Luis Pablo Júlvez
Annals of Translational Medicine
 2022;
10
(12)
:654
Is it time to retire sentinel lymph node biopsy and use multi-omics prediction models?
Rosalind Kieran, Mehmet Goksu, Susanne Crocamo, Bruno de Paula
Annals of Translational Medicine
 2022;
10
(12)
:655

Original Article

A novel clinical dynamic stereopsis assessment based on autostereoscopic display system
Yiyao Wang, Jing Zhong, Mengyi Cheng, Jijing Li, Ke Ma, Xiaoqing Hu, Naiyang Li, Haowen Liang, Zhengyuan Zhu, Jianying Zhou, Jin Yuan
Annals of Translational Medicine
 2022;
10
(12)
:656
Comparison of the efficacy and safety of caplacizumab versus placebo in thrombotic thrombocytopenic purpura: a meta-analysis and systematic review based on randomized controlled trials
Bin Chen, Xihong Li, Dongqiong Xiao, Rodrigo Daminello Raimundo, Ruixi Zhou, Yupeng Lei
Annals of Translational Medicine
 2022;
10
(12)
:657
Correlation of the characteristics of symptomatic intracranial atherosclerotic plaques with stroke types and risk of stroke recurrence: a cohort study
Huayun Jiang, Kaixuan Ren, Tiantian Li, Chengqun Qian, Shenchu Gong, Tianle Wang, Li Zhu
Annals of Translational Medicine
 2022;
10
(12)
:658
Lung transplantation for bronchiolitis obliterans after hematopoietic stem cell transplantation: a retrospective single-center study
Jialong Liang, Yuan Chen, Jintao Zhou, Huixing Li, Mingfeng Zheng, Feng Liu, Shugao Ye, Jingyu Chen, Yong Ji
Annals of Translational Medicine
 2022;
10
(12)
:659
Clinical efficacy of endoscopic antireflux mucosectomy vs. Stretta radiofrequency in the treatment of gastroesophageal reflux disease: a retrospective, single-center cohort study
Xinke Sui, Xiaopei Gao, Lu Zhang, Bin Zhang, Changqing Zhong, Yan Chen, Xiaoying Wang, Dou Li, Wei Wu, Lianyong Li
Annals of Translational Medicine
 2022;
10
(12)
:660
Seronegative rheumatic arthritis has milder inflammation and bone erosion in an ultrasound study of disease-modifying anti-rheumatic drugs (DMARDs)-naïve Chinese cohort
Dongfang Lin, Minjing Zhao, Yanli Zhang, Ya Xie, Junyan Cao, Yunfeng Pan
Annals of Translational Medicine
 2022;
10
(12)
:661
Soluble guanylate cyclase (sGC) stimulator vericiguat alleviates myocardial ischemia-reperfusion injury by improving microcirculation
Yun Cai, Beijian Zhang, Adilan Shalamu, Tingwen Gao, Junbo Ge
Annals of Translational Medicine
 2022;
10
(12)
:662
Down-regulated expression of miR-99a is associated with lymph node metastasis and predicts poor outcome in stage IB cervical squamous cell carcinoma: a case-control study
Gongyi Zhang, Rong Zhang, Ping Bai, Shumin Li, Jing Zuo, Yuanyuan Zhang, Mei Liu, Lingying Wu
Annals of Translational Medicine
 2022;
10
(12)
:663
Effectiveness and safety of decompression alone versus decompression plus fusion for lumbar spinal stenosis with degenerative spondylolisthesis: a systematic review and meta-analysis
Zhubin Shen, Xiaojing Guan, Rui Wang, Qian Xue, Ding Zhang, Yuan Zong, Wenxuan Ma, Ruijian Zhuge, Zhiming Liu, Changhao He, Li Guo, Fei Yin
Annals of Translational Medicine
 2022;
10
(12)
:664
Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis
Zhefan Xie, Tingting Xia, Dongxue Wu, Li Che, Wei Zhang, Xingdong Cai, Shengming Liu
Annals of Translational Medicine
 2022;
10
(12)
:665
The predictive value of tumor volume reduction ratio on three-dimensional endorectal ultrasound for tumor response to chemoradiotherapy for locally advanced rectal cancer
Limei Chen, Xiaoyin Liu, Wenjing Zhang, Si Qin, Yimin Wang, Jing Lin, Qiu Chen, Guangjian Liu
Annals of Translational Medicine
 2022;
10
(12)
:666
The effects of dexmedetomidine on the cognitive function of mild cognitive impairment (MCI) rats
Qian Zhou, Dongjin Xie, Ting Chen, Youguang Gao, Lanying Lin, Xianzhong Lin
Annals of Translational Medicine
 2022;
10
(12)
:667
Diagnostic study on clinical feasibility of an AI-based diagnostic system as a second reader on mobile CT images: a preliminary result
Kaiyue Diao, Yuntian Chen, Ying Liu, Bo-Jiang Chen, Wan-Jiang Li, Lin Zhang, Ya-Li Qu, Tong Zhang, Yun Zhang, Min Wu, Kang Li, Bin Song
Annals of Translational Medicine
 2022;
10
(12)
:668
Bioinformatics analysis identifies diagnostic biomarkers and their correlation with immune infiltration in diabetic nephropathy
Menglan Huang, Zhengxi Zhu, Cong Nong, Zhao Liang, Jingxue Ma, Guangzhi Li
Annals of Translational Medicine
 2022;
10
(12)
:669
Evaluation of the impact of reference tooth morphology and alignment on model measurement accuracy
Zhi Mao, Yi-Fan Jia, Yi-Fan Zhang, Jing Xu, Zhi-Na Wu, Feng Mao, Yi Zhang, Min Hu
Annals of Translational Medicine
 2022;
10
(12)
:670
Network pharmacology-based analysis of the effects of puerarin on sarcopenia
Xufeng Chen, Yan Wang, Meige Liu, Xiaodong Song, Dong Wang, Jun Zhang
Annals of Translational Medicine
 2022;
10
(12)
:671
Application of metagenomic next-generation sequencing for the diagnosis of intracranial infection of Listeria monocytogenes
Jing Li, You Zhang, Quanquan Zhang, Shiqi Lu, Fang Huang, Jun Wang
Annals of Translational Medicine
 2022;
10
(12)
:672
Improvement of surgical techniques for orthotopic single lung transplantation in rats
Peigen Gao, Chongwu Li, Ye Ning, Junqi Wu, Pei Zhang, Xiucheng Liu, Yiliang Su, Deping Zhao, Chang Chen
Annals of Translational Medicine
 2022;
10
(12)
:673
Bortezomib, epirubicin, and dexamethasone (PAD) results in superior free-progression survival compared to bortezomib, cyclophosphamide, and dexamethasone (VCD) treatment in non-transplantation newly diagnosed multiple myeloma patients aged between 50 to 65: a retrospective single-center analysis in non-transplant patients
Liang Chen, Ke Yi, Hongyan Lan, Yajun Zhang, Simin Jin, Xiaoyu Mou, Hongming Xian, Weijun Fu, Rong Li
Annals of Translational Medicine
 2022;
10
(12)
:674
Development and validation of a nomogram based on the hospital information system for quantitative assessment of the risk of cardiocerebrovascular complications of diabetes
Xin Xi, Guizhi Yin, Xiaoyong Wang, Xuesong Li
Annals of Translational Medicine
 2022;
10
(12)
:675
A prediction model with measured sentiment scores for the risk of in-hospital mortality in acute pancreatitis: a retrospective cohort study
Zhanxiao Liu, Ya Yang, Huanhuan Song, Ji Luo
Annals of Translational Medicine
 2022;
10
(12)
:676
Total flavones from Sceptridium ternatum alleviate pulmonary hypertension through inhibiting the proliferation of vascular endothelial cells
Qinglin Li, Wenxiu Xin, Haiyin Ding, Yiwen Zhang, Xiaowei Zheng, Yujia Liu, Ping Huang
Annals of Translational Medicine
 2022;
10
(12)
:677
Establishing a predictive model of hypoparathyroidism after total thyroidectomy and central lymph node dissection for postoperative calcium supplementation selectively
Tao Huang, Xiang Zhong, Tianyi He, Wei Zhang, Zhixian He
Annals of Translational Medicine
 2022;
10
(12)
:678
Aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism: a systematic review and meta-analysis
Hongjiao Gao, Rong Luo, Jindie Li, Haoming Tian
Annals of Translational Medicine
 2022;
10
(12)
:679
Bioinformatics analysis combined with experiments to verify potential autophagy genes in wound healing
Yong-Fang Wu, Da-Lang Fang, Jie Wei
Annals of Translational Medicine
 2022;
10
(12)
:680
Exogenous H2S promotes ion channel reconstruction to regulate colonic motility in rats with dinitrobenzene sulfonic acid-induced colitis
Ying Liu, Ribin Liao, Zhanrong Qiang, Wenjun Yang, Jie Cao
Annals of Translational Medicine
 2022;
10
(12)
:681
Developing a prediction model for estimating adrenocorticotropic hormone changes in patients undergoing scheduled open hepatectomy
Yu Guan, Jie Tang, Jiali Yu, Yiqi Zhu, Ailun Li, Fang Fang, Jing Cang
Annals of Translational Medicine
 2022;
10
(12)
:682
MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6
Zhuli Peng, Zhihui Mai, Feng Xiao, Guanqi Liu, Yixuan Wang, Shanshan Xie, Hong Ai
Annals of Translational Medicine
 2022;
10
(12)
:683
Efficacy and safety of Sanfeng Tongqiao Diwan in patients with allergic rhinitis: a single-arm clinical trial in China
Haisheng Hu, Jiaying Luo, Jing Ma, Zhiman Liang, Jinyu Dai, Wenxin Wang, Jinglin Zhong, Loushi Tian, Baoqing Sun
Annals of Translational Medicine
 2022;
10
(12)
:684
Protective effects of muscone on traumatic spinal cord injury in rats
Chao Yu, Fei Gui, Qian Huang, Yuanmeng Luo, Zili Zeng, Ruifu Li, Liang Guo
Annals of Translational Medicine
 2022;
10
(12)
:685
Establishment and validation of analytical methods for 15 hazardous drugs by UPLC-Q/Orbitrap-HRMS
Bo Yu, Yang Wang, Zhou Geng, Yuchen Qu, Jie Pan, Qing Zhai
Annals of Translational Medicine
 2022;
10
(12)
:686
Influencing factors of and multiple paths to high performance in multidisciplinary scientific research cooperation in colleges in China: a fuzzy-set qualitative comparative analysis
Jing Xue, Xing Liu, Qun Qin, Weihong Huang, Song Feng, Hua Guo
Annals of Translational Medicine
 2022;
10
(12)
:687
The efficacy and safety of self-administered acupressure on respiratory tract infection in chronic kidney disease: a randomized controlled trial
Meifang Liu, Hongqin Sheng, Jiahui Huang, Meiling Xuan, Wenwei Ouyang, Yanmei Zhang, Shuzhen Zhou, Lu Zeng, Lizhe Fu, Yin Chen, Xinyi Huang, Kaiqi Huang, Yifan Wu, Xusheng Liu, Lei Zhang
Annals of Translational Medicine
 2022;
10
(12)
:688
CD44 potentiates hepatocellular carcinoma migration and extrahepatic metastases via the AKT/ERK signaling CXCR4 axis
Peiyi Xie, Jiuliang Yan, Mengyuan Wu, Hui Li, Zheng Chen, Mincheng Yu, Bo Zhang, Lingli Chen, Lei Jin, Binghai Zhou, Xiaoqiang Li, Yongsheng Xiao, Yongfeng Xu, Jiang Long, Jubo Zhang, Lei Guo
Annals of Translational Medicine
 2022;
10
(12)
:689
Intrinsic network changes associated with cognitive impairment in patients with hearing loss and tinnitus: a resting-state functional magnetic resonance imaging study
Xiaobo Ma, Wei Li, Qian Wang, Xueying He, Xiaoxia Qu, Ting Li, Lirong Zhang, Zhaohui Liu
Annals of Translational Medicine
 2022;
10
(12)
:690
Icariin promotes the repair of bone marrow mesenchymal stem cells in rabbit knee cartilage defects via the BMP/Smad pathway
Feng Jiao, Wang Tang, Jie Wang, Donghua Liu, Hongyi Zhang, Dongming Tang
Annals of Translational Medicine
 2022;
10
(12)
:691
Evaluation on clinical performance of the new low-value platelet measurement mode (PLT-8X) of BC-6800Plus
Yimin Shen, Dongmei Liu, Yong Wang, Jun Cao, Shuaishuai Zhang, Hui Wen, Qiuqiu Dong, Dong Zheng, Jun Qiu
Annals of Translational Medicine
 2022;
10
(12)
:692
Midkine promotes kidney injury in diabetic kidney disease by increasing neutrophil extracellular traps formation
Gaohong Liu, Xiaojun Ren, Yousong Li, Han Li
Annals of Translational Medicine
 2022;
10
(12)
:693
Development and external validation of prognostic nomograms for liver disease-free and overall survival in locally advanced rectal cancer with neoadjuvant therapy: a post cohort study based on the FOWARC trial
Jiaming Zhou, Tuoyang Li, Yuanlv Xiao, Jinxin Lin, Xiaoqiong Chen, Shaoyong Peng, Mingzhe Huang, Xuebin Shi, Linbin Cai, Pinzhu Huang, Meijin Huang
Annals of Translational Medicine
 2022;
10
(12)
:694
Down-regulation of LCN2 attenuates retinal vascular dysfunction and caspase-1-mediated pyroptosis in diabetes mellitus
Xingjie Su, Pingping Zhou, Yanxiu Qi
Annals of Translational Medicine
 2022;
10
(12)
:695
WX-0593 combined with an epithelial growth factor receptor (EGFR) monoclonal antibody in the treatment of xenograft tumors carrying triple EGFR mutations
Qingmei Zheng, Dongmei Chen, Xinmei Wang, Yingying Yang, Shuyong Zhao, Xin Dong, Cuicui Ma, Xin Zhang, Huicheng Duan, Yan Sun, Shansong Zheng
Annals of Translational Medicine
 2022;
10
(12)
:696
Study on the clinical features and prognosis of second and third generations of COVID-19
Chao Deng, Liping Chen, Chao Ji, Yaoming Yuan, Yu Hou, Jinghui Li
Annals of Translational Medicine
 2022;
10
(12)
:697
Bioinformatic analysis of cancer-associated fibroblast related gene signature as a predictive model in clinical outcomes and immune characteristics of gastric cancer
Jiehao Zhang, Nannan Zhang, Xin Fu, Weizhen Wang, Hui Liu, Michael J. McKay, Pornngarm Dejkriengkraikul, Yongzhan Nie
Annals of Translational Medicine
 2022;
10
(12)
:698
Systemic glucocorticoid-free therapy with adalimumab plus immunosuppressants versus conventional therapy in treatment-naïve Vogt-Koyanagi-Harada disease patients
Shizhao Yang, Tianyu Tao, Zhaohuai Li, Binyao Chen, Zhaohao Huang, Xiuxing Liu, He Li, Lihui Xie, Wen Feng, Wenru Su
Annals of Translational Medicine
 2022;
10
(12)
:699
Anti-atherosclerotic effects of genistein in preventing ox-low-density lipoprotein-induced smooth muscle-derived foam cell formation via inhibiting SRC expression and L-Ca channel currents
Wei Zhang, Liming Zhang, Xiaosi Zhang
Annals of Translational Medicine
 2022;
10
(12)
:700
Bioinformatics analysis of SOXF family genes reveals potential regulatory mechanism and diagnostic value in cancers
Dan Wu, Chuan Jiang, Jing-Jing Zheng, De-Sheng Luo, Ji Ma, Hai-Feng Que, Chao Li, Chao Ma, Hui-Yong Wang, Wei Wang, Hong-Tao Xu
Annals of Translational Medicine
 2022;
10
(12)
:701
Prognostic impact of high-risk factors and KRAS mutation in patients with stage II deficient mismatch repair colon cancer: a retrospective cohort study
Yuting Zhang, Zehua Wu, Bin Zhang, Huabin Hu, Jianwei Zhang, Yi Chen, Miaomiao Ding, Yabing Cao, Yanhong Deng
Annals of Translational Medicine
 2022;
10
(12)
:702
Clinical study of poorly differentiated head and neck squamous cell carcinoma: a prospective cohort study in China
Shuo Ding, Wei Guo, Gaofei Yin, Nuan Li, Hongfei Liu, Junwei Huang, Zheng Yang, Hongbo Xu, Xiaohong Chen, Yang Zhang, Zhigang Huang
Annals of Translational Medicine
 2022;
10
(12)
:703
The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial
Yanbing Su, Jianxing Zhang, Huanwei Wang, Yangkui Gu, Handong Ouyang, Wan Huang
Annals of Translational Medicine
 2022;
10
(12)
:704
Docetaxel population pharmacokinetic modelling and simulation in Chinese cancer patients
Jian Wei, Yuwen Zhang, Ze Li, Xingang Li, Chenglong Zhao
Annals of Translational Medicine
 2022;
10
(12)
:705
Next-generation sequencing and targeted quantitative real-time polymerase chain reaction for detection of Akebiae Caulis in the traditional Chinese medical formula Longdan Xiegan Wan
Yinsen Song, Zhenzhen Yang, Peipei Wang, Ke Song, Sisen Zhang, Tianli Fan
Annals of Translational Medicine
 2022;
10
(12)
:706
Molecular mechanism of betulin palliative therapy for chronic obstructive pulmonary disease (COPD) based on P2X7 receptor target of gated ion channel
Pengfei Jiao, Yingrui Wang, Tianqing Sang, Jing Jiao, Yameng Li
Annals of Translational Medicine
 2022;
10
(12)
:707
Efficacy and safety of combined treatment with pembrolizumab in patients with locally advanced or metastatic esophageal squamous cell carcinoma in the real world
Pei Zhang, Xiaobin Hou, Boning Cai, Wei Yu, Jing Chen, Xiang Huang, Ye Li, Mingyue Zeng, Zhipeng Ren, Emmanuel Gabriel, Baolin Qu, Fang Liu
Annals of Translational Medicine
 2022;
10
(12)
:708
Does pretreatment elevated calcitonin level cause the poor prognosis in patients with medullary thyroid cancer?
Han Zhang, Daqi Zhang, Chengqiu Sui, Jingting Li, Canxiao Li, Qiao He, Rui Du, Yishen Zhao, Yantao Fu, Le Zhou, Tie Wang, Gianlorenzo Dionigi, Nan Liang, Hui Sun
Annals of Translational Medicine
 2022;
10
(12)
:709
Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties
Renhua Ni, Zehao Jing, Chenao Xiong, Dexuan Meng, Chongbin Wei, Hong Cai
Annals of Translational Medicine
 2022;
10
(12)
:710

Review Article

Gene polymorphisms in asthma: a narrative review
Fei Shi, Yu Zhang, Chen Qiu
Annals of Translational Medicine
 2022;
10
(12)
:711
DDX5: an expectable treater for viral infection- a literature review
Minghui Hu, Hongying Zheng, Jingqi Wu, Yue Sun, Tianying Wang, Shuang Chen
Annals of Translational Medicine
 2022;
10
(12)
:712
Narrative review of the relationship between the maternal-fetal interface immune tolerance and the onset of preeclampsia
Fangyuan Luo, Jun Yue, Lingling Li, Jie Mei, Xinghui Liu, Yu Huang
Annals of Translational Medicine
 2022;
10
(12)
:713
Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review
Fangbing Li, Yilin Wang, Tianxiang Hu, Yejun Wu
Annals of Translational Medicine
 2022;
10
(12)
:714
Design and optimization of auditory prostheses using the finite element method: a narrative review
Qianli Cheng, Han Yu, Junpei Liu, Qi Zheng, Yanru Bai, Guangjian Ni
Annals of Translational Medicine
 2022;
10
(12)
:715
A narrative review of cortical visual prosthesis systems: the latest progress and significance of nanotechnology for the future
Xi Liu, Peipei Chen, Xuemeng Ding, Anning Liu, Peng Li, Cheng Sun, Huaijin Guan
Annals of Translational Medicine
 2022;
10
(12)
:716

Study Protocol

Developing the RIGHT-COI&F extension for the reporting conflicts of interest and funding in practice guidelines: study protocol
Yangqin Xun, Janne Estill, Mengjuan Ren, Ping Wang, Nan Yang, Zijun Wang, Ying Zhu, Renfeng Su, Yaolong Chen, Elie A. Akl
Annals of Translational Medicine
 2022;
10
(12)
:717

Case Report

Successful secondary radical operation on unretractable metastatic platinum-sensitive recurrent ovarian cancer by immunotherapy: a case report
Li Sun, Hua Li, Sulan Wei, Meng Yang, Shaoqiong Deng
Annals of Translational Medicine
 2022;
10
(12)
:718
Two case reports of non-small cell lung cancer patients harboring acquired EGFR T790M-cis-C797S benefit from immune checkpoint inhibitor combined with platinum-based doublet chemotherapy
Zizheng Song, Guanying Ren, Ling Hu, Xiaolei Wang, Jin Song, Youchao Jia, Guofa Zhao, Aimin Zang, Haiwei Du, Ying Sun, Xiaopeng Zhao
Annals of Translational Medicine
 2022;
10
(12)
:719
Percutaneous full endoscopic C1 laminectomy for developmental atlantal stenosis with myelopathy: a case report of three cases and review of the literature
Yongpeng Lin, Siyuan Rao, Bingxin Liu, Yueli Sun, Shuai Zhao, Guoyi Su, Shudong Chen, Yongjin Li, Bolai Chen
Annals of Translational Medicine
 2022;
10
(12)
:720
Clinical observation of allergic contact stomatitis treated with Kangfuxin solution as adjuvant: case report
Xiaoyi Zang, Wenjuan Du, Funeng Geng, Panpan Meng, Lingling E, Haizhong Zhang, Xinling Wang, Lin Li, Rui Xiao
Annals of Translational Medicine
 2022;
10
(12)
:721
A case report of the metagenomics next-generation sequencing for early detection of central nervous system mucormycosis with successful rescue in patient with recurrent chronic lymphocytic leukemia
Jiaojiao Zhang, Jing Luo, Xiangqin Weng, Yongmei Zhu, Gaurav Goyal, Fabiana Perna, Manuel Espinoza-Gutarra, Lu Jiang, Li Chen, Jian-Qing Mi
Annals of Translational Medicine
 2022;
10
(12)
:722

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article


Review Article