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ATM Annual Report 2020

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2021. In 2020, ATM has made great progress under the join-efforts of experts worldwide.

- More than 1700 papers have been published in ATM in 2020.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,452,243 times in 2020.
- The number of total citations by SCI journals has significantly increased to 21,008 until Dec. 2020
- The pageviews of ATM is increasing significantly, with a total of 2,230,740 hits in 2020.

Recent Developments in Cataract Surgery

We would like to share with the readers at large the contributions from invited authors who provided their unique and expert perspectives on the important and critical topics of this focus series titled “Recent Developments in Cataract Surgery”.

Infective Endocarditis in the 21st Century

Infective endocarditis (IE) is a consequence of the localized or systemic diffusion of pathogens, generally bacteria or fungi, in the heart. Complications of heart valve endocarditis (HVE) develops in approximately from 1% to 43% of patients. Development of any degree of valve regurgitation in patients with LV dysfunction have a higher mortality risk than those without valve regurgitation. This fact alone remains the primary driver for surgery in patients with HVE.

Current State of Intraoperative Imaging

This series of Annals of Translational Medicine presents a collection of review articles on the current state of intraoperative imaging in spinal surgery. The rates of spine surgery and spinal instrumentation have increased tremendously in the past two decades. This increase has been accompanied by technological innovations and advances that are expanding the horizon of spinal surgery and making these procedures increasingly feasible, safe and efficient for the management of a wide range of disorders.

Pain Therapy

In this series, recent developments on the assessment and pain management have been presented. The authors focused their attention on a wide field of applications: from new delivery systems for analgesics to pain assessment in clinical trials or interventional management of neuropathic pain.

Reviewer of the Month

Over the year, many ATM reviewers have made outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work. We would like to highlight a few of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer.

Ovarian Cancer: State of the Art and Perspectives of Clinical Research

Ovarian cancer is composed of three histological subtypes: epithelial (90%), germ cell (5%), and sex cord stromal cell (5%). Epithelial ovarian cancer (EOC) is the most lethal gynecological disorder due to lack of effective early detection strategies. The forthcoming special series focuses on several key elements that are essential for an understanding of this heterogeneous group of malignancies.

Lung Emphysema

Lung emphysema represents a major public health burden and still accounts for 5% of all deaths worldwide. Hence, it is essential to further understand this disease in order to develop effective diagnostic and therapeutic strategies. In our focused series, we highlight this disease from several aspects beginning with advances in imaging, going through developments of surgical and interventional therapies of lung volume reduction, perioperative anesthesiologic considerations, and giving an overview of the different phenotypes of chronic obstructive disease and correlations between lung cancer and lung emphysema, and concluding with lung transplantation for lung emphysema.

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Vol 9, No 7 (April, 2021)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Day-90 survival in critically-ill patients with COVID-19 and hydroxychloroquine: a propensity analysis

Martin Cour, Camille Amaz, Julien Bohé, Thomas Rimmelé, Michel Ovize, Laurent Argaud

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A prognostic nomogram for women with primary ovarian signet-ring cell carcinoma

Xijuan Wang, Xiurong Ke, Junxia Min

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Adenosine A3 receptor activated in H₂O₂ oxidative stress of primary open-angle glaucoma

Ziyu Zhou, Zhaolin Gao, Weitao Yan, Yun Zhang, Jufang Huang, Kun Xiong

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Mitochondrial dysfunction attenuates rapid regeneration in livers with toxin-induced fibrosis

Zheyong Li, Yuelong Liang, Hanning Ying, Mingyu Chen, Xiaoyan He, Yifan Wang, Yifan Tong, Xiujun Cai

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countfitteR: efficient selection of count distributions to assess DNA damage

Jarosław Chilimoniuk, Alicja Gosiewska, Jadwiga Słowik, Romano Weiss, P. Markus Deckert, Stefan Rödiger, Michał Burdukiewicz

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CHI3L1 alleviate acute liver injury by inhibiting Th1 cells differentiation through STAT3 signaling pathway

Shaopeng Zhang, Xinzheng Dai, Yong Shi, Xiaowen Zhu, Yongjiu Dai, Xiaofeng Qian, Jian Gu

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Machine learning models to predict red blood cell transfusion in patients undergoing mitral valve surgery

Shun Liu, Rong Zhou, Xing-Qiu Xia, He Ren, Le-Ye Wang, Rui-Rui Sang, Mi Jiang, Chun-Chen Yang, Huan Liu, Lai Wei, Rui-Ming Rong

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Gradient nanostructured titanium stimulates cell responses in vitro and enhances osseointegration in vivo

Nan-Jue Cao, Yu-He Zhu, Fei Gao, Chen Liang, Zhen-Bo Wang, Yue Zhang, Chun-Ping Hao, Wei Wang

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Geriatric nutritional risk index as an independent prognostic factor in locally advanced nasopharyngeal carcinoma treated using radical concurrent chemoradiotherapy: a retrospective cohort study

Qing-Nan Tang, Hui-Zhi Qiu, Xiao-Qing Sun, Shan-Shan Guo, Li-Ting Liu, Yue-Feng Wen, Sai-Lan Liu, Hao-Jun Xie, Yu-Jing Liang, Xue-Song Sun, Xiao-Yun Li, Jin-Jie Yan, Jin-Hao Yang, Dong-Xiang Wen, Ling Guo, Lin-Quan Tang, Qiu-Yan Chen, Hai-Qiang Mai

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ESM1 promotes triple-negative breast cancer cell proliferation through activating AKT/NF-κB/Cyclin D1 pathway

Wentong Liu, Yang Yang, Bincan He, Fengjun Ma, Fengzeng Sun, Min Guo, Min Zhang, Zhiqiang Dong

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False-positive colloidal gold-based immunochromatographic strip assay reactions for antibodies to SARS-CoV-2 in patients with autoimmune diseases

Xiumei Xiao, Qingtao Zhou, Jinghao Zhu, Lin Sun, Hua Zhang, Yongchang Sun, Jinxia Zhao, Liyan Cui

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Oral care and oral assessment guide in breast cancer patients receiving everolimus and exemestane: subanalysis of a randomized controlled trial (Oral Care-BC)

Masahiro Umeda, Yoshihide Ota, Kosuke Kashiwabara, Naoki Hayashi, Mariko Naito, Toshinari Yamashita, Hirofumi Mukai, Katsuhiko Nakatsukasa, Takeshi Amemiya, Ken-Ichi Watanabe, Hironobu Hata, Yuichiro Kikawa, Naoki Taniike, Takashi Yamanaka, Sachiyo Mitsunaga, Kazuhiko Nakagami, Moriyasu Adachi, Naoto Kondo, Yasuyuki Shibuya, Naoki Niikura

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A four-year observation of corneal densitometry after implantable collamer lens V4c implantation

Jing Zhao, Wen Yang, Jiao Zhao, Yang Shen, Ling Sun, Tian Han, Xiaoying Wang, Peijun Yao, Xingtao Zhou

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Hemoglobin A1c modifies the association between triglyceride and time in hypoglycemia determined by flash glucose monitoring in adults with type 1 diabetes: implications for individualized therapy and decision-making

Yiwen Liu, Jie Yu, Chifa Ma, Shuli He, Fan Ping, Huabing Zhang, Wei Li, Lingling Xu, Xinhua Xiao, Yuxiu Li

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Development and validation of predictive model for lymph node metastasis in endometrial cancer: a SEER analysis

Xingchen Li, Yuan Cheng, Yangyang Dong, Jingyi Zhou, Zhiqi Wang, Xiaoping Li, Jianliu Wang

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Premature ovarian insufficiency patients with viable embryos derived from autologous oocytes through repeated oocyte retrievals could obtain reasonable cumulative pregnancy outcomes following frozen-embryo transfer

Xiuxian Zhu, Jing Ye, Yonglun Fu

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Impact of variceal eradication on rebleeding and prognosis in cirrhotic patients undergoing secondary prophylaxis

Xing Wang, Jinni Luo, Chuan Liu, Yanna Liu, Xiaoying Wu, Fengping Zheng, Zhuofu Wen, Hong Tian, Xiuqing Wei, Yunwei Guo, Jianzhong Li, Xiaoliang Chen, Jin Tao, Xiaolong Qi, Bin Wu

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A 12-week, randomized, double-blind, placebo-controlled study assessing the efficacy of EGHB010, a standardized extract of Paeoniae radix and Glycyrrhizae radix, in patients with early age-related macular degeneration

Joo Young Kim, Mirinae Kim, Rae Young Kim, Woo Kyung Park, Young-Hoon Park

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UAP1L1 plays an oncogene-like role in glioma through promoting proliferation and inhibiting apoptosis

Zhuanyi Yang, Zhiquan Yang, Zhongliang Hu, Bo Li, Dingyang Liu, Xiaoyu Chen, Ying Wang, Deyun Feng

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Risk factors and outcomes of intraoperative atrial fibrillation in patients undergoing thoracoscopic anatomic lung surgery

Chaoyang Tong, Qi Zhang, Yuan Liu, Meiying Xu, Jingxiang Wu, Hui Cao

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A simple lectin-based biochip might display the potential clinical value of glycomics in patients with spontaneous intracerebral hemorrhage

Lei Ye, Yong-Sheng Fang, Xiao-Xue Li, Yi Gao, Sheng-Sheng Liu, Qiang Chen, Qiang Wu, Hong-Wei Cheng, Wei-Dong Du

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A computed tomography (CT)-derived radiomics approach for predicting primary co-mutations involving TP53 and epidermal growth factor receptor (EGFR) in patients with advanced lung adenocarcinomas (LUAD)

Ying Zhu, Yu-Biao Guo, Di Xu, Jing Zhang, Zhen-Guo Liu, Xi Wu, Xiao-Yu Yang, Dan-Dan Chang, Min Xu, Jing Yan, Zun-Fu Ke, Shi-Ting Feng, Yang-Li Liu

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Autologous esophageal mucosa with polyglycolic acid transplantation and temporary stent implantation can prevent stenosis after circumferential endoscopic submucosal dissection

Yong Liu, Zhengqi Li, Lizhou Dou, Yueming Zhang, Shun He, Jiqing Zhu, Yan Ke, Xudong Liu, Yumeng Liu, Hoiloi Ng, Guiqi Wang

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Non-invasive assessment of urinary bladder compliance using ultrasound: first validation study based on clinical urodynamic study

Xinyu Zhang, Douglas A. Husmann, Lance A. Mynderse, Azra Alizad, Mostafa Fatemi

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Role of a successful spontaneous breathing trial in ventilator liberation in brain-injured patients

Zhong-Hua Shi, Annemijn H. Jonkman, Pieter Roel Tuinman, Guang-Qiang Chen, Ming Xu, Yan-Lin Yang, Leo M. A. Heunks, Jian-Xin Zhou

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Potential functional variants of KIAA genes are associated with breast cancer risk in a case control study

Jing Zhou, Congcong Chen, Sijun Liu, Wen Zhou, Jiangbo Du, Yue Jiang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Zhibin Hu, Jiaping Chen, Hongbing Shen

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Automatic classification of heterogeneous slit-illumination images using an ensemble of cost-sensitive convolutional neural networks

Jiewei Jiang, Liming Wang, Haoran Fu, Erping Long, Yibin Sun, Ruiyang Li, Zhongwen Li, Mingmin Zhu, Zhenzhen Liu, Jingjing Chen, Zhuoling Lin, Xiaohang Wu, Dongni Wang, Xiyang Liu, Haotian Lin

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Analysis of tumor mutation burden combined with immune infiltrates in endometrial cancer

Jun Zhang, Lanfen An, Xing Zhou, Rui Shi, Hongbo Wang

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Mass SARS-CoV-2 molecular and serological screening of medical staff and patients in Hangzhou, China: no evidence of RNA detection, low seroprevalence, and limited exposure risk in the hospital setting

Jun Huang, Lu Zhang, Shengjun Wu, Jie Lu, Fengying Li, Yulan Cheng, Qi Zhang, Guiling Li, Haitao Yu, Zhian Le, Xiaowen He, Yanjun Ding, Daniel Candotti, Xinyou Xie, Jun Zhang

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Advances in the surgical outcomes of 300 cases of pure laparoscopic living donor right hemihepatectomy divided into three periods of 100 cases: a single-centre case series

Eui Soo Han, Kyung-Suk Suh, Kwang-Woong Lee, Nam-Joon Yi, Suk Kyun Hong, Jeong-Moo Lee, Kwang Pyo Hong, Ming Yuan Tan

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Real-world big data demonstrates prevalence trends and developmental patterns of myopia in China: a retrospective, multicenter study

Erping Long, Xiaohang Wu, Xiaohu Ding, Yahan Yang, Xun Wang, Chong Guo, Xiayin Zhang, Kexin Chen, Tongyong Yu, Dongxuan Wu, Xutu Zhao, Zhenzhen Liu, Yizhi Liu, Haotian Lin

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A nomogram to predict survival in patients with acute-on-chronic hepatitis B liver failure after liver transplantation

Liang Chen, Jiebin Zhang, Tongyu Lu, Jianye Cai, Jun Zheng, Jia Yao, Shuhong Yi, Hua Li, Guihua Chen, Hui Zhao, Yingcai Zhang, Yang Yang

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Visit-to-visit variability of lipid and cardiovascular events in patients with familial hypercholesterolemia

Ye-Xuan Cao, Liang Li, Hui-Wen Zhang, Jing-Lu Jin, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Qian Dong, Rui-Xia Xu, Jing Sun, Jian-Jun Li

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Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/ PI3K/AKT axis

Yazhou Wang, Huahu Guo, Zhengkui Zhang, Qi Wang, Xiaodong Tian, Yinmo Yang

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A predictive model for postthrombotic syndrome in proximal deep vein thrombosis patients

Peng Qiu, Junchao Liu, Fuzhen Wan, Yuqian Chen, Kaichuang Ye, Jinbao Qin, Qun Huang, Xinwu Lu

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Comprehensive serum metabolic and proteomic characterization on cognitive dysfunction in Parkinson’s disease

Na Zhang, Chuanxi Tang, Qiong Ma, Wei Wang, Mingyu Shi, Xiaoyu Zhou, Fangfang Chen, Chengcheng Ma, Xue Li, Gang Chen, Dianshuai Gao

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Association between renal function and retinal neurodegeneration in Chinese patients with type 2 diabetes mellitus

Xia Gong, Wei Wang, Wangting Li, Ling Jin, Lanhua Wang, Jie Meng, Kun Xiong, Yuting Li, Xiao Han, Xiaoling Liang, Wenyong Huang

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Effect of norepinephrine challenge on cardiovascular determinants assessed using a mathematical model in septic shock: a physiological study

Huaiwu He, Siyi Yuan, Yun Long, Dawei Liu, Xiang Zhou, Can Ince

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pN1 but not pN0/N2 predicts survival benefits of prophylactic cranial irradiation in small-cell lung cancer patients after surgery

Haitang Yang, Mohammad Faisal Al-Hurani, Jianlin Xu, Liwen Fan, Ralph A. Schmid, Heng Zhao, Feng Yao

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Nogo-B promotes epithelial-mesenchymal transition in lung fibrosis via PERK branch of the endoplasmic reticulum stress pathway

Ying Zhu, Meng Yang, Xue-Hui Li, Wu-Jian Xu, Wei Gao, Yu-Han Chen, Jian-Dong Li, Qiang Li

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Marriage contributes to higher obesity risk in China: findings from the China Health and Nutrition Survey

Jinli Liu, Malgorzata A. Garstka, Zhonglin Chai, Yifan Chen, Veronika Lipkova, Mark E. Cooper, Kingsley Katleho Mokoena, Youfa Wang, Lei Zhang

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Recombinant human bone morphogenetic protein-4 enhances tendon-to-bone attachment healing in a murine model of rotator cuff tear

Huabin Chen, Zhanwen Wang, Li Zhou, Bing Wu, Hongbin Lu, Ciliu Zhang, Tao Zhang

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New sequential algorithm using Mac-2 binding protein glycosylation isomer to detect advanced carotid artery atherosclerosis

Huiyul Park, Dae Won Jun, Hoon-Ki Park, Kye-Yeung Park, Hwan-Sik Hwang

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Robot-assisted mandibular angle osteotomy using electromagnetic navigation

Mengzhe Sun, Li Lin, Xiaojun Chen, Cheng Xu, Mar Aung Zin, Wenqing Han, Gang Chai

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Autocrined leptin promotes proliferation of non-small cell lung cancer (NSCLC) via PI3K/AKT and p53 pathways

Jin Wang, Fachen Zhou, Fengzhou Li, Bing Wang, Yiying Hu, Xia Li

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Comprehensive analysis of tumor microenvironment and identification of an immune signature to predict the prognosis and immunotherapeutic response in lung squamous cell carcinoma

Jinlong Wu, Chengfeng Xu, Xin Guan, Da Ni, Xuhui Yang, Zhiyin Yang, Mingsong Wang

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Identification of four genes and biological characteristics associated with acute spinal cord injury in rats integrated bioinformatics analysis

Qiang Li, Bo Li, Bo Tao, Chenxi Zhao, Baoyou Fan, Qi Wang, Chao Sun, Huiquan Duan, Yilin Pang, Xuanhao Fu, Shiqing Feng

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Nomograms for predicting progression-free survival and overall survival after surgery and concurrent chemoradiotherapy for glioblastoma: a retrospective cohort study

Lin Zheng, Zhi-Rui Zhou, Minghan Shi, Haiyan Chen, Qian-Qian Yu, Yang Yang, Lihong Liu, Lili Zhang, Yinglu Guo, Xiaofeng Zhou, Chao Li, Qichun Wei

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An MSCT-based radiomics nomogram combined with clinical factors can identify Crohn’s disease and ulcerative colitis

Hui Li, Yan Mo, Chencui Huang, Qingguo Ren, Xiaona Xia, Xiaomin Nan, Xinyan Shuai, Xiangshui Meng

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The outcomes in STEMI patients with high thrombus burden treated by deferred versus immediate stent implantation in primary percutaneous coronary intervention: a prospective cohort study

Demou Luo, Xiangming Hu, Shuo Sun, Chenyang Wang, Xing Yang, Jingguang Ye, Xiaosheng Guo, Shenghui Xu, Boyu Sun, Haojian Dong, Yingling Zhou

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Pathological prognostic factors of retroperitoneal liposarcoma: comprehensive clinicopathological analysis of 124 cases

Pingping Sun, Ru Ma, Gang Liu, Lingling Wang, Hong Chang, Yan Li

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Cost-utility analysis of imrecoxib compared with celecoxib for patients with osteoarthritis

Xueshan Sun, Xuemei Zhen, Xiaoqian Hu, Yuanyuan Li, Shuyan Gu, Yuxuan Gu, Zixuan Zhao, Wei Yang, Hengjin Dong

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Intraductal administration of N-methyl-N-nitrosourea as a novel rodent mammary tumor model

Dongcheng Gao, Jianhua Liu, Jingping Yuan, Juan Wu, Xinwen Kuang, Deguang Kong, Weijie Zheng, Guannan Wang, Saraswati Sukumar, Yi Tu, Chuang Chen, Shengrong Sun

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Review Article

Application and outlook of topical hemostatic materials: a narrative review

Yuting Zhong, Huayu Hu, Ningning Min, Yufan Wei, Xiangdong Li, Xiru Li

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A narrative review of circular RNAs as potential biomarkers and therapeutic targets for cardiovascular diseases

Chi Liu, Nan Li, Guifeng Dai, Omer Cavdar, Hong Fang

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A narrative review of exosomes in vascular calcification

Zheng Qin, Ruoxi Liao, Yuqin Xiong, Luojia Jiang, Jiameng Li, Liya Wang, Mei Han, Si Sun, Jiwen Geng, Qinbo Yang, Zhuyun Zhang, Yupei Li, Heyue Du, Baihai Su

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Study Protocol

Rationale and design of a prospective, multicenter, cross-sectional study of appropriateness evaluation of the prescription of non-vitamin K antagonist oral anticoagulants for Chinese atrial fibrillation patients (Chi-NOACs-AF trial)

Zheng Ding, Chi Zhang, Yi-Yi Qian, Na Wang, Zhi-Chun Gu, Hang Xu, Ying-Li Zheng, for the Chi-NOACs-AF investigators

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Targeted temperature management at 33 degrees Celsius in patients with high-grade aneurysmal subarachnoid hemorrhage: a protocol for a multicenter randomized controlled study

Xin Qu, Feng Shang, Hao Zhao, Meng Qi, Weitao Cheng, Yueqiao Xu, Lidan Jiang, Wenjing Chen, Ning Wang, Hongqi Zhang

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Case Report

Novel approach of rigid bronchoscopy concurrent with cesarean section and bronchial arterial embolism for patients with massive hemoptysis during pregnancy: case reports and literature review

Xue Yang, Wei Ma, Xin Shi, Xiao Sun, Yumei Wei, Ziguang Yan, Shuangling Li

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Bronchoalveolar lavage-detected SARS-CoV-2 infection in presence of serial negative nasopharyngeal swabs: a case report

Grazia Caci, Fabrizio Minervini, Carsten Fechner, Justus E. Roos, Ellen C. Obermann, Andrea Azzola

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Isotretinoin induced small vessel vasculitis: a life-threatening pulmonary-renal syndrome—a case report

Srinadh Annangi, Sara Pasha

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Column in Laboratory Medicine¹

How will emerging SARS-CoV-2 variants impact herd immunity?

Giuseppe Lippi, Brandon M. Henry

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Editorial Commentary

Postoperative adjuvant EGFR-TKIs for resected EGFR-mutant NSCLC—opportunities and obstacles

Brielle A. Parris, Steven Leong, Henry Marshall, Ian A. Yang, Rayleen V. Bowman, Kwun M. Fong

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Editorial on Medical Aerosol in Acute and Critical Care²

Demystifying medical aerosols in acute and critical care

Zhe Luo, James B. Fink

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Review Article on Medical Aerosol in Acute and Critical Care²

Aerosol delivery via invasive ventilation: a narrative review

Hui-Ling Lin, James B. Fink, Huiqing Ge

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Aerosol delivery via noninvasive ventilation: role of models and bioanalysis

Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mohamed E. A. Abdelrahim

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Narrative review of practical aspects of aerosol delivery via high-flow nasal cannula

Jie Li, James B. Fink

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Review of aerosol delivery in the emergency department

Patricia A. Dailey, Courtney M. Shockley

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Fugitive aerosols in the intensive care unit: a narrative review

Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin

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A path to successful patient outcomes through aerosol drug delivery to children: a narrative review

Arzu Ari

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Essentials for aerosol delivery to term and pre-term infants

Andrew R. Clark

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Measurements of deposited aerosol dose in infants and small children

Timothy E. Corcoran

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Administration of dry powders during respiratory supports

Wei-Ren Ke, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Patricia Tang, Lan Chen, Donghao Chen, Hak-Kim Chan

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Inhaled pulmonary vasodilators: a narrative review

Kai Liu, Huan Wang, Shen-Ji Yu, Guo-Wei Tu, Zhe Luo

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Inhaled antibiotics during mechanical ventilation—why it will work

Maxime Desgrouas, Stephan Ehrmann

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Editorial on Transgender Surgery³

Editorial on gender affirming surgery

Oscar J. Manrique, John A. Persing, Xiaona Lu

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Original Article on Transgender Surgery³

Hockey stick incision: a modified technique for chest wall masculinization

Alexandra Junn, Sumun Khetpal, John Smetona, Jacob Dinis, Allister Hirschman, Mohammad Ali Mozaffari, Anusha Singh, Ann Hui Ching, Michael Alperovich, Xiaona Lu, John A. Persing

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A comparison of perioperative safety for breast augmentation in cis- vs. trans patients

Kyle S. Gabrick, Fouad Chouiari, Kitae E. Park, Omar Allam, Mohammed Ali Mozaffari, John A. Persing, Michael Alperovich

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Perception of femininity and attractiveness in Facial Feminization Surgery

Ann Hui Ching, Allister Hirschman, Xiaona Lu, Seija Maniskas, Antonio J. Forte, Michael Alperovich, John A. Persing

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Necessity of facial contouring in feminization surgery for Chinese transgender females

Dong Li, Liang Xu, Zheyuan Yu, Jie Yuan, Min Wei

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The strategy for vaginal rejuvenation: CO₂ laser or vaginoplasty?

Chen Cheng, Yi Cao, Sun-Xiang Ma, Kai-Xiang Cheng, Ying-Fan Zhang, Yang Liu

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Guiding the conversation—types of regret after gender-affirming surgery and their associated etiologies

Sasha Karan Narayan, Rayisa Hontscharuk, Sara Danker, Jess Guerriero, Angela Carter, Gaines Blasdel, Rachel Bluebond-Langner, Randi Ettner, Asa Radix, Loren Schechter, Jens Urs Berli

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Review Article on Transgender Surgery³

Narrative review of facial gender surgery: approaches and techniques for the frontal sinus and upper third of the face

Matthew Louis, Roberto Travieso, Norah Oles, Devin Coon

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Surgical techniques of phalloplasty in transgender patients: a systematic review

Daniel Boczar, Maria T. Huayllani, Humza Y. Saleem, Gabriela Cinotto, Francisco R. Avila, Salam Kassis, Xiaona Lu, Brian D. Rinker, Antonio J. Forte

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Single versus two-stage phalloplasty for transgender female-to-male patients: a systematic review of the literature

Maria T. Huayllani, Daniel Boczar, Humza Y. Saleem, Gabriela Cinotto, Francisco R. Avila, Oscar J. Manrique, Pedro Ciudad, Brian D. Rinker, Antonio J. Forte

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Imaging evaluation for the diagnosis and management of complications of gender-affirming surgeries

Justin T. Stowell, Allie M. Metcalfe, Priyanka Jha

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Multidisciplinary approach to imaging for gender-affirming surgery: engaging surgeons, radiologists, and patients to ensure a positive imaging experience

Justin T. Stowell, Vaz A. Zavaletta, Evelyn F. Carroll, Frances W. Grimstad

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Breast augmentation in the transgender patient: narrative review of current techniques and complications

Jenna C. Bekeny, Elizabeth G. Zolper, Oscar J. Manrique, Kenneth L. Fan, Gabriel Del Corral

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Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes

Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique

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Systematic review of fertility preservation options in transgender patients: a guide for plastic surgeons

Maria Yan, Samyd S. Bustos, Doga Kuruoglu, Pedro Ciudad, Antonio J. Forte, Esther A. Kim, Gabriel Del Corral, Oscar J. Manrique

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Point of care virtual surgical planning and 3D printing in facial gender confirmation surgery: a narrative review

Doga Kuruoglu, Maria Yan, Samyd S. Bustos, Jonathan M. Morris, Amy E. Alexander, Basel Sharaf

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Disclosure:

1. The series “Column in Laboratory Medicine” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Giuseppe Lippi is serving as the unpaid Guest Editor for the series.

2. The series “Medical Aerosol in Acute and Critical Care” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. James B. Fink and Zhe Luo served as the unpaid Guest Editors for the series.

3. The series “Transgender Surgery” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Oscar J. Manrique, John A Persing, and Xiaona Lu served as the unpaid Guest Editors for the series.

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Surgical treatment of recurrent acute lymphoblastic leukemia with humeral osteomyelitis as the first symptom: a case report and literature review

Yiyang Liu, Chun Zhang, Lifeng Shen, Haiyong Ren, Yangjun Lao, Meng Zhou, Huifang Jiang, Bingyuan Lin

Editorial

Editorial to the head and neck cancer—series

Mukund Seshadri

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

Artificial intelligence in molecular imaging: at the crossroads of revolutions in medical diagnosis

Steven P. Rowe

Present and future of hyperthermic intrathoracic chemotherapy (HITHOC) in thoracic surgical oncology

Marcello Migliore

Hyperthermic intrathoracic chemotherapy (HITHOC) should be included in the guidelines for malignant pleural mesothelioma

Marcello Migliore, Michael Ried, Laureano Molins, Marco Lucchi, Marcello Ambrogi, Tamas F. Molnar, Hans-Stefan Hofmann

Podocytes and microRNA-30/Cx43 axis in diabetic nephropathy

Seo Rin Kim, Soon Hyo Kwon

Carotid artery stenosis and stroke: controversies in prevention and treatment

Kosmas I. Paraskevas

Esophageal surgery in the 21^st century

Ory Wiesel

Unresolved basic issues in hepatology

Ralf Weiskirchen, Wolfgang Stremmel

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Risk stratification and corresponding postoperative treatment strategies for occult contralateral lymph node metastasis in pyriform sinus squamous cell carcinoma patients with ipsilateral node-positive necks

Yu Heng, Xiaoke Zhu, Liang Zhou, Ming Zhang, Kenan Li, Lei Tao

Assessment of HCMV-encoded microRNAs in plasma as potential biomarkers in pregnant women with adverse pregnancy outcomes

Zhiying Gao, Likun Zhou, Jing Bai, Meng Ding, Deshui Liu, Shaohai Zheng, Yuewen Li, Xiulan Li, Xiaojuan Wang, Ming Jin, Huizi Shangting, Changchun Qiu, Cheng Wang, Xiaojie Zhang, Chenyu Zhang, Xi Chen

Hemodynamic testing using three-dimensional printing and computational fluid dynamics preoperatively may provide more information in mitral repair than traditional image dataset

Hao Wang, Hongning Song, Yuanting Yang, Zhiyong Wu, Rui Hu, Jinling Chen, Juan Guo, Yijia Wang, Dan Jia, Sheng Cao, Qing Zhou, Ruiqiang Guo

Circulating endothelial microparticles: a promising biomarker of acute kidney injury after cardiac surgery with cardiopulmonary bypass

Jian Ma, Hao-Xiang Yuan, Ya-Ting Chen, Da-Sheng Ning, Xiao-Jun Liu, Yue-Ming Peng, Chao Chen, Yuan-Kai Song, Yu-Peng Jian, Yan Li, Zui Liu, Zhi-Jun Ou, Jing-Song Ou

Quality and consistency of clinical practice guidelines for treating children with COVID-19

Qinyuan Li, Qi Zhou, Yangqin Xun, Hui Liu, Qianling Shi, Zijun Wang, Siya Zhao, Xiao Liu, Enmei Liu, Zhou Fu, Yaolong Chen, Zhengxiu Luo

Probabilistic ratiocination of hepatocellular carcinoma after resection: evaluation of expected to be promising approaches

Wei Dong, Xinggang Guo, Fuchen Liu, Wenli Zhang, Zongyan Wang, Tao Tian, Qifei Tao, Guojun Hou, Weiping Zhou, Seogsong Jeong, Qiang Xia, Hui Liu

Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells

Seon Mee Kang, Hye Sook Jung, Min Jeong Kwon, Soon Hee Lee, Jeong Hyun Park

A novel preoperative predictive model of 90-day mortality after liver resection for huge hepatocellular carcinoma

Yue Yin, Jian-Wen Cheng, Fei-Yu Chen, Xu-Xiao Chen, Xin Zhang, Ao Huang, De-Zhen Guo, Yu-Peng Wang, Ya Cao, Jia Fan, Jian Zhou, Xin-Rong Yang

Hyaluronic acid vs. physiological saline for enlarging deficient gingival papillae: a randomized controlled clinical trial and an in vitro study

Jing Ni, Zhe Zhong, Yifan Wu, Rong Shu, Yiqun Wu, Chaolun Li

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes

Christoph Knappich, Thomas Lang, Pavlos Tsantilas, Sofie Schmid, Michael Kallmayer, Bernhard Haller, Hans-Henning Eckstein

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Development and validation of a novel prognostic nomogram including tumor deposits could better predict survival for colorectal cancer: a population-based study

Rui Bai, Yinuo Tan, Dan Li, Mengyuan Yang, Linzhen Yu, Ying Yuan, Xuefeng Fang

Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy

Tao Xu, Jian Jia, Na Xu, Chao Ye, Fen Zheng, Yan Yuan, Guo-Qing Zhu, Yi-Yang Zhan

PGE1 triggers Nrf2/HO-1 signal pathway to resist hemin-induced toxicity in mouse cortical neurons

Jiabing Shen, Mao-Sheng Cao, Tingting Zhou, Ying Chen, Jingjing Liang, Yan Song, Chengbin Xue, Mao-Hong Cao, Kaifu Ke

Homocysteine alters vasoreactivity of human internal mammary artery by affecting the K_Ca channel family

Wen-Tao Sun, Hong-Mei Xue, Hai-Tao Hou, Huan-Xin Chen, Jun Wang, Guo-Wei He, Qin Yang

The 100 most cited articles on lung cancer screening: a bibliometric analysis

Meng Li, Qiang Cai, Jing-Wen Ma, Li Zhang, Claudia I. Henschke

Exploring the barriers of patients with diabetic foot complications in China: a qualitative interview study

Xiaoli Liu, Hongling Chu, Jinghui Zhao, Rui Qiao, Yuqiang Liu, Nan Li, Lin Zeng, Xiaoxiao Wang, Liyuan Tao, Hua Zhang, Yanyan Shi, Lin Zhuo, Long Zhang, Yiming Zhao

Co-expression network of long non-coding RNA and mRNA reveals molecular phenotype changes in kidney development of prenatal chlorpyrifos exposure in a mouse model

Bingjue Li, Wenyu Xiang, Jing Qin, Qiannan Xu, Shi Feng, Yucheng Wang, Jianghua Chen, Hong Jiang

A clinical nomogram incorporating salivary Desulfovibrio desulfuricans level and oral hygiene index for predicting colorectal cancer

Yao Wang, Yao Zhang, Zheng Wang, Jian Tang, Dong-Xing Cao, Yun Qian, Yuan-Hong Xie, Hai-Ying Chen, Ying-Xuan Chen, Zhao-Fei Chen, Jing-Yuan Fang

The functional method: experience from the Robert Debré Hospital

Philippe Souchet, Jean-Pierre Delaby, Matthieu Campana, Jason Chinnappa, Brice Ilharreborde, Anne-Laure Simon

Predictive factors associated with the clinical outcome of intertrochanteric hip fracture in high-risk elderly patients treated with total hip arthroplasty versus percutaneous external fixation

Jun Zhang, Jie Zhu, Zaiyang Liu, Yumei Zhang, Yunfei Jin, Min Wang, Xia Zhang, Kaiqi He, Yuan Zhang

Lobectomy vs. sublobectomy for stage I non-small-cell lung cancer: a meta-analysis

Fang Lv, Bing Wang, Qi Xue, Shugeng Gao

Intravenous fluids for pain management in head and neck cancer patients undergoing chemoradiation

Charlotte I. Rivers, Austin J. Iovoli, Udit Chatterjee, Gregory M. Hermann, Anurag K. Singh

Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration

Un Chul Park, Susanna S. Park, Bo Hee Kim, Sung Wook Park, Young Joo Kim, Whitney Cary, Johnathon D. Anderson, Jan A. Nolta, Hyeong Gon Yu

^99mTc-mebrofenin hepatobiliary scintigraphy and volume metrics before liver preparation: correlations and discrepancies in non-cirrhotic patients

Boris Guiu, Emmanuel Deshayes, Fabrizio Panaro, Florian Sanglier, Caterina Cusumano, Astrid Herrerro, Olivia Sgarbura, Nicolas Molinari, François Quenet, Christophe Cassinotto

High risk of pulmonary embolism in acute respiratory distress syndrome related to COVID-19: an observational controlled-cohort study

Victor de Roubin, Faustine Reynaud, Rémi Coudroy, Maeva Rodriguez, Grégoire Monseau, Florent Joly, Justine Bardin, Florence Boissier, Delphine Chatellier, Anne Veinstein, René Robert, Jean-Pierre Frat, Arnaud W. Thille

Association of cardiovascular disease with 30-day hospital readmission in Chinese patients receiving maintenance dialysis

Rui Chen, Chao Yang, Ming Zhu, Hong Chu, Jinwei Wang, Bixia Gao, Lili Liu, Yifang Jiang, Yu Lin, Jingyi Wu, Guilan Kong, Fang Wang, Luxia Zhang, Minghui Zhao, on behalf of the China Kidney Disease Network Work Group

Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells

Rong Xue, Jiannan Qiu, Song Wei, Mu Liu, Qi Wang, Peng Wang, Bowen Sha, Hao Wang, Yong Shi, Jinren Zhou, Jianhua Rao, Ling Lu

Age differences in ocular demodicosis: Demodex profiles and clinical manifestations

Jing Li, Xiaohui Luo, Yinglin Liao, Lingyi Liang

Properties and gene expression profiling of acquired radioresistance in mouse breast cancer cells

Feng Qin, Qiang Fan, Peter K.N. Yu, Waleed Abdelbagi Almahi, Peizhong Kong, Miaomiao Yang, Wei Cao, Lili Nie, Guodong Chen, Wei Han

Leukocyte subtypes and adverse clinical outcomes in patients with acute ischemic cerebrovascular events

Anxin Wang, Kehua Quan, Xue Tian, Yingting Zuo, Xia Meng, Pan Chen, Hao Li, Yongjun Wang

Low serum IgG4 level: a potential diagnostic biomarker for IgA nephropathy

Xinyu Tian, Zhuan Cui, Song Wang, Yuejuan Pan, Lata A, Xinxin Chen, Xiaoxiao Wang, Xiaoyan Qiu, Zhenling Deng, Yue Wang

Comparison of the modified sinus tarsi approach versus the extensile lateral approach for displaced intra-articular calcaneal fractures

Chao Ma, Jiaju Zhao, Yong Zhang, Nan Yi, Jupu Zhou, Zhicheng Zuo, Bo Jiang

Matched pair analysis to evaluate weight loss during radiation therapy for head and neck cancer as a prognostic factor for survival

Hye Ri Han, Gregory M. Hermann, Sung Jun Ma, Austin J. Iovoli, Kimberly E. Wooten, Hassan Arshad, Vishal Gupta, Ryan P. McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Jon M. Chan, Mary E. Platek, Andrew D. Ray, Fangyi Gu, Wesley L. Hicks Jr, Anurag K. Singh

Immune checkpoint inhibitor plus tyrosine kinase inhibitor for unresectable hepatocellular carcinoma in the real world

Diyang Xie, Qiman Sun, Xiaoying Wang, Jian Zhou, Jia Fan, Zhenggang Ren, Qiang Gao

Epidemiological and clinical characteristics of suspected COVID-19 patients in the isolation ward in Guangzhou, China: a cohort study

Shaoqiang Li, Zhengtu Li, Liyan Chen, Jing Cheng, Yangqing Zhan, Feng Yang, Qian Jiang, Xiaofen Su, Yingying Xie, Zhile Wu, Wenliang Guo, Weili Gu, Nanshan Zhong, Shiyue Li, Feng Ye

In-hospital prognosis of first-ever noncardiogenic ischemic stroke in patients with and without indication for prestroke antiplatelet therapy: Chinese Stroke Center Alliance

Yu-Yuan Xu, Hong-Qiu Gu, Zi-Xiao Li, Yun-Yun Xiong, Qi Zhou, Li-Ping Liu, Xing-Quan Zhao, Yi-Long Wang, Xia Meng, Yong-Jun Wang, on behalf of the CSCA Investigators

Accuracy of matrix-assisted laser desorption ionization time-of-flight mass spectrometry for direct bacterial identification from culture-positive urine samples

Bin Sun, Wei Wang, Ping Ma, Bing Gu

Diabetic nephropathy in mice is aggravated by the absence of podocyte IRE1 and is correlated with reduced kidney ADH1 expression

Liping Xie, Kaifeng Guo, Sijia Lu, Ning Wang, Yanping Wang, Haibing Chen, Junli Liu, Weiping Jia

Integrated genomic and transcriptomic analysis suggests KRT18 mutation and MTAP are key genetic alterations related to the prognosis between astrocytoma and glioblastoma

Zhiyong Li, Yinghui Jin, Qingping Zou, Xiaofeng Shi, Qianchao Wu, Zhiying Lin, Qun He, Guanglong Huang, Songtao Qi

The G199X and V157fs mutations in the TP53 gene promote malignancy in serous ovarian cancer: an analysis using whole-exome sequencing

Dan Su, Man Nie, Jun Yue

Evaluating the association between single nucleotide polymorphisms in the stonin 2 (STON2) gene and keratoconus in a Han Chinese population

Jing Zhang, Yue Li, Yiqin Dai, Jianjiang Xu

Residual β-cell function after 10 years of autoimmune type 1 diabetes: prevalence, possible determinants, and implications for metabolism

Jin Cheng, Min Yin, Xiaohan Tang, Xiang Yan, Yuting Xie, Binbin He, Xia Li, Zhiguang Zhou

Decision-support for treatment with ¹⁷⁷Lu-PSMA: machine learning predicts response with high accuracy based on PSMA-PET/CT and clinical parameters

Sobhan Moazemi, Annette Erle, Zain Khurshid, Susanne Lütje, Michael Muders, Markus Essler, Thomas Schultz, Ralph A. Bundschuh

Clinical outcomes of bivalirudin versus heparin in atrial fibrillation patients undergoing percutaneous left atrial appendage occlusion

Xiaochun Zhang, Qinchun Jin, Dehong Kong, Cuizhen Pan, Xian Zhang, Dan Zhou, Zhiyun Shen, Daxin Zhou, Junbo Ge

Estimating the amplitude spectrum area of ventricular fibrillation during cardiopulmonary resuscitation using only ECG waveform

Feng Zuo, Youde Ding, Chenxi Dai, Liang Wei, Yushun Gong, Juan Wang, Yiming Shen, Yongqin Li

The pharmacodynamic effect of terlipressin versus high-dose octreotide in reducing hepatic venous pressure gradient: a randomized controlled trial

Bing Li, Jie Chen, Chun-Qing Zhang, Guang-Chuan Wang, Jin-Hua Hu, Jian-Jun Luo, Wen Zhang, Yi-Chao Wei, Xiao-Qing Zeng, Shi-Yao Chen

Clinical characteristics and outcome of tumor-associated acute pancreatitis: a single-center cohort study

Yangyang Xiong, Yi Zhao, Xianlin Han, Guorong Chen, John Windsor, Dong Wu, Jiaming Qian

Analysis of factors associated with unintended initial dissection of the posterior plane during small incision lenticule extraction

Ke Zheng, Tian Han, Yinan Han, Fang Liu, Xingtao Zhou

Nucleotide polymorphism in ARDS outcome: a whole exome sequencing association study

Jing-Yuan Xu, Ai-Ran Liu, Zong-Sheng Wu, Jian-Feng Xie, Xiao-Xiao Qu, Cai-Hua Li, Shan-Shan Meng, Song-Qiao Liu, Cong-Shan Yang, Ling Liu, Ying-Zi Huang, Feng-Mei Guo, Yi Yang, Hai-Bo Qiu

Evaluation of preoperative corneal astigmatism using swept-source optical biometry in Chinese cataract surgery candidates with high myopia: a prospective, comparative observational study

Yehui Tan, Liangping Liu, Jianbing Li, Yingyan Qin, Ao Sun, Mingxing Wu

Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism

Zhiwei Zhou, Xiuyuan Zheng, Xin Mei, Wengpeng Li, Songtao Qi, Yuefei Deng, Bingxi Lei

Matched pair analysis for comparison of survival outcome of alternative regimens to standard three-weekly cisplatin-based concurrent chemoradiation of head and neck cancer

Hye Ri Han, Sung Jun Ma, Gregory M. Hermann, Austin J. Iovoli, Kimberly E. Wooten, Hassan Arshad, Vishal Gupta, Ryan P. McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Jon M. Chan, Mary E. Platek, Andrew D. Ray, Fangyi Gu, Wesley L. Hicks Jr, Anurag K. Singh

Differential prognostic implications of gastric adenocarcinoma based on Lauren’s classification: a Surveillance, Epidemiology, and End Results (SEER)-based cohort study

Dehua Tang, Muhan Ni, Hao Zhu, Jun Cao, Lin Zhou, Shanshan Shen, Chunyan Peng, Ying Lv, Guifang Xu, Lei Wang, Xiaoping Zou

An application of machine learning based on real-world data: Mining features of fibrinogen in clinical stages of lung cancer between sexes

Fangtao Yin, Hongyu Zhu, Songlin Hong, Chen Sun, Jie Wang, Mengting Sun, Lin Xu, Xiaoxiao Wang, Rong Yin

Plasma EGFR mutation abundance affects clinical response to first-line EGFR-TKIs in patients with advanced non-small cell lung cancer

Xiaohong Wang, Yonggang Liu, Zhiying Meng, Yun Wu, Shubin Wang, Gaowa Jin, Yingchun Qin, Fengyun Wang, Jing Wang, Haifei Zhou, Xiaoxing Su, Xiuhua Fu, Xiaolan Wang, Xiaoyu Shi, Zhenping Wen, Xiaoqiong Jia, Qiong Qin, Yongqiang Gao, Weidong Guo, Shun Lu

Mortality prediction for patients with acute respiratory distress syndrome based on machine learning: a population-based study

Bingsheng Huang, Dong Liang, Rushi Zou, Xiaxia Yu, Guo Dan, Haofan Huang, Heng Liu, Yong Liu

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

Combined grip strength and calf circumference as a useful prognostic system in patients with liver diseases: a large cohort study

Hiroki Nishikawa, Kazunori Yoh, Hirayuki Enomoto, Takashi Nishimura, Shuhei Nishiguchi, Hiroko Iijima

Global alternative splicing landscape of skeletal muscle atrophy induced by hindlimb unloading

Junjie Sun, Hua Yang, Xiaoming Yang, Xin Chen, Hua Xu, Yuntian Shen, Fei Ding, Xiaosong Gu, Jianwei Zhu, Hualin Sun

CYR61 as a potential biomarker for the preoperative identification of muscle-invasive bladder cancers

Huang Chen, Yu Liu, Chuanzhen Cao, Hao Xi, Wenting Chen, Wei Zheng, Xin Dong, Shan Zheng, Lin Li, Jianhui Ma, Yanning Gao, Jianzhong Shou

Genetic identification of pathogenic variations of the DMD gene: a retrospective study from 10,481 neonatal patients based on next-generation sequencing data

Tiantian Xiao, Bingbing Wu, Yun Cao, Renchao Liu, Guoqiang Cheng, Laishuan Wang, Deyi Zhuang, Zhengyan Zhao, Huijun Wang, Wenhao Zhou

Correlation between serum lipid and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study

Minmin Shao, Guofeng Xiong, Guangzao Xiang, Shile Xu, Liqun Zhang

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A. Nolta, Susanna S. Park

The ‘Hybrid method’ for the treatment of congenital clubfoot

Federico Canavese, Mounira Mansour, Léa Souchon, Antoine Samba, Alain Dimeglio

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

Controlling nutritional status score as a prognostic marker to predict overall survival in resected biliary tract cancers

Lejia Sun, Si Su, Jianping Xiong, Wenmo Hu, Lei Liu, Haifeng Xu, Shunda Du, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang, Yilei Mao

Development and validation of a collagen signature-based nomogram for preoperatively predicting lymph node metastasis and prognosis in colorectal cancer

Meiting Fu, Dexin Chen, Fuzheng Luo, Guangxing Wang, Shuoyu Xu, Yadong Wang, Caihong Sun, Xueqin Xu, Aimin Li, Shuangmu Zhuo, Side Liu, Jun Yan

Inhibition of sphingosine kinase 2 down-regulates ERK/c-Myc pathway and reduces cell proliferation in human epithelial ovarian cancer

Lan Dai, Wenjing Wang, Yixuan Liu, Keqi Song, Wen Di

Log odds of positive lymph nodes is an excellent prognostic factor for patients with rectal cancer after neoadjuvant chemoradiotherapy

Tianlei Xu, Lin Zhang, Liang Yu, Yuelu Zhu, Hui Fang, Bo Chen, Haizeng Zhang

Upregulation of the long noncoding RNA UBOX5 antisense RNA 1 (UBOX5-AS1) under hypoxic conditions promotes epithelial-mesenchymal transition in endometriosis

Hengwei Liu, Haitang He, Zhibing Zhang, Lili Wang, Ling Zhang, Yi Liu, Wenqian Xiong

Prevalence and clinical characteristics of antibiotics associated drug induced liver injury

Jin Hwa Park, Susie Hong, Dae Won Jun, Jai Hoon Yoon, Kang Nyeong Lee, Hang Lak Lee, Oh Young Lee, Byung Chul Yoon, Ho Soon Choi

Analysis of gender-specific associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms and serum uric acid levels in Han Chinese

Jie Wu, Chaochao Ma, Jie Yi, Yu Chen, Ali Ye, Lingjun Kong, Ling Qiu, Tengda Xu

Related parameters of affinity and stability prediction of HLA-A*2402 restricted antigen peptides based on molecular docking

Changxin Huang, Jianfeng Chen, Fei Ding, Lili Yang, Siyu Zhang, Xuechun Wang, Yanfei Shi, Ying Zhu

Retinal degeneration in mice and humans with neuronal ceroid lipofuscinosis type 8

Elyse M. Salpeter, Brian C. Leonard, Antonio J. Lopez, Christopher J. Murphy, Sara Thomasy, Denise M. Imai, Kristin Grimsrud, K. C. Kent Lloyd, Jiong Yan, Rossana Sanchez Russo, Suma P. Shankar, Ala Moshiri

SPECTnet: a deep learning neural network for SPECT image reconstruction

Wenyi Shao, Steven P. Rowe, Yong Du

Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry

Michael A. Cummings, Sung Jun Ma, Paul Van Der Sloot, Michael T. Milano, Deepinder P. Singh, Anurag K. Singh

Characteristics and prognosis of telangiectatic osteosarcoma: a population-based study using the Surveillance, Epidemiology and End Results (SEER) database

Mingfang Xu, Nan Dai, Xueqin Yang, Wei Guan, Yu Pu, Dong Wang, Liangjun Yin, Mao Nie

Perilesional edema in brain metastases as predictive factor of response to systemic therapy in non-small cell lung cancer patients: a preliminary study

Montse Alemany, Marta Domènech, Andreas A. Argyriou, Noelia Vilariño, Carles Majós, Pablo Naval-Baudin, Anna Lucas, Ramón Palmero, Marta Simó, Ernest Nadal, Jordi Bruna

Problem-based learning and case-based learning in dental education

Haiyan Wang, Jing Xuan, Lijun Liu, Xuemin Shen, Yaoyang Xiong

Regional ventilation distribution in healthy lungs: can reference values be established for electrical impedance tomography parameters?

Lin Yang, Meng Dai, Xinsheng Cao, Knut Möller, Mantas Dargvainis, Inéz Frerichs, Tobias Becher, Feng Fu, Zhanqi Zhao

Surgical resection of primary tumors improved the prognosis of patients with bone metastasis of non-small cell lung cancer: a population-based and propensity score-matched study

Dan Tian, Xiaosong Ben, Sichao Wang, Weitao Zhuang, Jiming Tang, Liang Xie, Haiyu Zhou, Dongkun Zhang, Zihao Zhou, Ruiqing Shi, Cheng Deng, Yu Ding, Xuanye Zhang, Guibin Qiao

Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral bone

Hua-Jun Wang, Hugo Giambini, Ji-Wen Chen, Qiu-Shi Wang, Hui-Ge Hou, Si-Min Luo, Jun-Yuan Chen, Teng-Feng Zhuang, Yuan-Feng Chen, Ting-Ting Wu, Zhen-Gang Zha, You-Jie Liu, Xiao-Fei Zheng

Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway

Jingpei Li, Xiaohan Yang, Penghui Yang, Ke Xu, Xiaomin Peng, Weipeng Cai, Simin Zhao, Lei Hu, Zhuoyi Li, Fei Cui, Wei Wang, Guilin Peng, Xin Xu, Jianxing He, Jun Liu

Right ventricular systolic function is associated with health-related quality of life: a cross-sectional study in community-dwelling populations

Yong-Tai Liu, Jin-Zhi Lai, Fei-Fei Zhai, Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Zhuang Tian, Yan-Lin Zhu, Wei Chen, Hua Bai, Hui Wang, Ding-Ding Zhang, Li-Ying Cui, Zheng-Yu Jin, Yi-Cheng Zhu, Shu-Yang Zhang

Is analog preoperative planning still applicable?—comparison of accuracy of analog and computer preoperative planning methods in total hip arthroplasty

Julian Dutka, Slawomir Kiepura, Mateusz Bukowczan

The genomic characteristics of different progression patterns in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors

Jingwen Li, Chan Xiang, Yue Wang, Yan Zhou, Shuhui Cao, Xuxinyi Ling, Junyi Ye, Jingjing Zheng, Lin Shao, Hua Zhong, Yuchen Han

Development and validation of a novel miRNA classifier as a prognostic signature for stage II/III colorectal cancer

Junlan Feng, Qing Wei, Muqing Yang, Xiaodong Wang, Bin Liu, Jiyu Li

Study Protocol

Practice of adjunctive treatments in critically ill COVID–19 patients—rational for the multicenter observational PRoAcT-COVID study in The Netherlands

Christel M. A. Valk, Pien Swart, Leonoor S. Boers, Michela Botta, Lieuwe D. J. Bos, Marcelo Gama de Abreu, Liselotte Hol, Markus W. Hollmann, Janneke Horn, Ignacio Martin-Loeches, Guido Mazzinari, Sheila N. Myatra, Sunny G. Nijbroek, Neeltje M. Rosenberg, Willemke Stilma, Anissa M. Tsonas, Ward H. van der Ven, Ary Serpa Neto, Marcus J. Schultz, Frederique Paulus, for the PRoAcT-COVID collaborative group

Review Article

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

The modern approach to esophageal palliative and emergency surgery

Anny Godin, Moishe Liberman

The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis—a narrative review article

Wolfgang Stremmel, Martina Lukasova, Ralf Weiskirchen

Diagnostic management of nonalcoholic fatty liver disease: a transformational period in the development of diagnostic and predictive tools—a narrative review

Natalia Rosso, Adam M. Stephenson, Pablo J. Giraudi, Claudio Tiribelli

De novo gastroesophageal reflux disease esophageal surgery in bariatrics: a literature review and analysis of the current treatment options

Rene Aleman, Emanuele Lo Menzo, Samuel Szomstein, Raul J. Rosenthal

Pluripotent stem cell therapy for retinal diseases

Ishrat Ahmed, Robert J. Johnston Jr, Mandeep S. Singh

Narrative review of generative adversarial networks in medical and molecular imaging

Kazuhiro Koshino, Rudolf A. Werner, Martin G. Pomper, Ralph A. Bundschuh, Fujio Toriumi, Takahiro Higuchi, Steven P. Rowe

Clinical examination and classification systems of congenital clubfoot: a narrative review

Federico Canavese, Alain Dimeglio

Hepatic trauma

Rene Roberts, Rahul A. Sheth

Styloidogenic-cervical spondylotic internal jugular venous compression, a vascular disease related to several clinical neurological manifestations: diagnosis and treatment—a comprehensive literature review

Alba Scerrati, Nicoló Norri, Lorenzo Mongardi, Flavia Dones, Luca Ricciardi, Gianluca Trevisi, Erica Menegatti, Paolo Zamboni, Michele Alessandro Cavallo, Pasquale De Bonis

Acute kidney injury after lung transplantation: a narrative review

Lei Jing, Wenhui Chen, Lijuan Guo, Li Zhao, Chaoyang Liang, Jingyu Chen, Chen Wang

From Codivilla to Ponseti: historical narrative review on clubfoot treatment in Italy

Flavia Alberghina, Gianluca Testa, Sergio Monforte, Vito Pavone, Antonio Andreacchio

Paraesophageal hernia: to fundoplicate or not?

Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan

Revisiting hemochromatosis: genetic vs. phenotypic manifestations

Gregory J. Anderson, Edouard Bardou-Jacquet

Artificial intelligence for molecular neuroimaging

Amanda J. Boyle, Vincent C. Gaudet, Sandra E. Black, Neil Vasdev, Pedro Rosa-Neto, Katherine A. Zukotynski

Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry

Renato Salvador, Mario Costantini, Salvatore Tolone, Pietro Familiari, Ermenegildo Galliani, Bastianello Germanà, Edoardo Savarino, Stefano Merigliano, Michele Valmasoni

Robotics and minimally invasive esophageal surgery

Ealaf Shemmeri, Jon O. Wee

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Frank Tacke, Ralf Weiskirchen

Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

Jeff Rytlewski, Mohammed M. Milhem, Varun Monga

Endovascular management of pelvic trauma

Arlene Weir, Padraic Kennedy, Stella Joyce, David Ryan, Liam Spence, Mark McEntee, Michael Maher, Owen O’Connor

Liver failure—future challenges and remaining questions

Peter Lemmer, Josef Christian Pospiech, Ali Canbay

A Narrative Review of update in per oral endoscopic myotomy (POEM) and endoscopic esophageal surgery

Antony Delliturri, Ory Wiesel, Jason Shaw, Igor Brichkov

Clubfoot management in the Middle East: a survey-based review

Ismat Ghanem, Maroun Rizkallah

Multimodality carotid plaque tissue characterization and classification in the artificial intelligence paradigm: a narrative review for stroke application

Luca Saba, Skandha S. Sanagala, Suneet K. Gupta, Vijaya K. Koppula, Amer M. Johri, Narendra N. Khanna, Sophie Mavrogeni, John R. Laird, Gyan Pareek, Martin Miner, Petros P. S kakis, Athanasios Protogerou, Durga P. Misra, Vikas Agarwal, Aditya M. Sharma, Vijay Viswanathan, Vijay S. Rathore, Monika Turk, Raghu Kolluri, Klaudija Viskovic, Elisa Cuadrado-Godia, George D. Kitas, Neeraj Sharma, Andrew Nicolaides, Jasjit S. Suri

Evolving treatment paradigms in esophageal cancer

Ilit Turgeman, Irit Ben-Aharon

Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

Dairy consumption and hepatocellular carcinoma risk

Bodo C. Melnik

Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

Sangwan Park, Brian C. Leonard, Vijay Krishna Raghunathan, Soohyun Kim, Jennifer Y. Li, Mark J. Mannis, Christopher J. Murphy, Sara M. Thomasy

The role of bile acids in cholestatic liver injury

Shi-Ying Cai, James L. Boyer

Artificial intelligence in molecular imaging

Edward H. Herskovits

Propensity score matching with R: conventional methods and new features

Qin-Yu Zhao, Jing-Chao Luo, Ying Su, Yi-Jie Zhang, Guo-Wei Tu, Zhe Luo

The basic science of optic nerve regeneration

Lindsay Fague, Yin Allison Liu, Nicholas Marsh-Armstrong

New horizons in non-small-cell lung cancer patients with ipsilateral pleural dissemination (M1a): review of the literature

Hao Li, Taorui Liu, Zewen Sun, Zhenfan Wang, Xianping Liu, Fan Yang

Immune checkpoint inhibitors in lymphoma: challenges and opportunities

Haris Hatic, Devi Sampat, Gaurav Goyal

MicroRNA and diabetic retinopathy—biomarkers and novel therapeutics

Zeljka Smit-McBride, Lawrence S. Morse

Objective analysis of intermediate-term outcome of the Ponseti technique: a review of the experience from Los Angeles

Lewis E. Zionts, Edward Ebramzadeh, Sophia N. Sangiorgio

Clubfoot pathology in fetus and pathogenesis. A new pathogenetic theory based on pathology, imaging findings and biomechanics—a narrative review

Ernesto Ippolito, Giulio Gorgolini

Fluorescence-guided surgery of the esophagus

Paul Chandler, Ory Wiesel, Danny A. Sherwinter

Endovascular embolization in renal trauma: a narrative review

Tyler Andrew Smith, Adriene Eastaway, Duncan Hartt, Keith Bertram Quencer

Narrative review of vascular iatrogenic trauma and endovascular treatment

Tyler Andrew Smith, David Gage, Keith Bertram Quencer

Narrative Review of Carotid disease and the kidney

Luca Zanoli, Dimitri P. Mikhailidis

Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction

Vaia Florou, Sonam Puri, Ignacio Garrido-Laguna, Breelyn A. Wilky

Animal models of diabetic retinopathy

Jose Quiroz, Amirfarbod Yazdanyar

Hyperthermic intrathoracic chemotherapy (HITHOC): narrative review of the current literature, recommendations and future studies

Till Markowiak, Christopher Larisch, Hans-Stefan Hofmann, Michael Ried

The role of gut microbiome in modulating response to immune checkpoint inhibitor therapy in cancer

Abdul Rafeh Naqash, Alba J. Kihn-Alarcón, Chara Stavraka, Kathleen Kerrigan, Saman Maleki Vareki, David James Pinato, Sonam Puri

Narrative review of the management of oral mucositis during chemoradiation for head and neck cancer

Lauren F. Judge, Mark K. Farrugia, Anurag K. Singh

The quick carotid scan for prevention of strokes due to carotid artery disease

George S. Lavenson Jr, Charles A. Andersen

The modern approach to esophagectomy—review of the shift towards minimally invasive surgery

Daniel P. Dolan, Scott J. Swanson

It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis

Amit Khurana, Nilofer Sayed, Prince Allawadhi, Ralf Weiskirchen

Non-alcoholic fatty liver diseases: current challenges and future directions

Elke Roeb

Targeting vascular endothelial growth factor using retinal gene therapy

Sook H. Chung, Sonia L. Frick, Glenn Yiu

The dark side of immunotherapy

Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami

Molecular landscape of head and neck cancer and implications for therapy

Camile S. Farah

Biomarkers of therapeutic response with immune checkpoint inhibitors

Poorva Bindal, Jhanelle E. Gray, Theresa A. Boyle, Vaia Florou, Sonam Puri

Systematic review of the effectiveness of carotid surgery and endovascular carotid stenting versus best medical treatment in managing symptomatic acute carotid artery dissection

Sherif Sultan, Niamh Hynes, Yogesh Acharya, Edel Kavanagh, Fionnuala Jordan

Exosomes as therapeutic vehicles in liver diseases

Jingyi Ding, Ju Wang, Jiajia Chen

Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Louise B. D. Banning, Stan Benjamens, Reinoud P. H. Bokkers, Clark J. Zeebregts, Robert A. Pol

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

Rolf Teschke, Jack Uetrecht

Therapeutic strategies in Wilson disease: pathophysiology and mode of action

Wolfgang Stremmel, Ralf Weiskirchen

Gene therapy for inherited retinal diseases

Yan Nuzbrokh, Sara D. Ragi, Stephen H. Tsang

Autoimmune hepatitis—is histology conclusive?

Andrea Beer, Hans Peter Dienes

CAR T-cell therapy in mature lymphoid malignancies: clinical opportunities and challenges

Mayur Narkhede, Amitkumar Mehta, Stephen M. Ansell, Gaurav Goyal

A review of the application of machine learning in molecular imaging

Lin Yin, Zhen Cao, Kun Wang, Jie Tian, Xing Yang, Jianhua Zhang

Narrative review of theoretical considerations regarding HITHOC between past and future

Tamas F. Molnar, Andras Drozgyik

A narrative review of new treatment options for chronic kidney disease in type 2 diabetes

Frederik Persson, Rikke Borg, Peter Rossing

Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery

Luigi Bonavina

New frontiers in esophageal radiology

Eric J. Schmidlin, Ritu R. Gill

Esophageal disease in lung transplant patients

John S. Young, Antonio Coppolino

Splenic trauma: endovascular treatment approach

Maxwell Cretcher, Catherine E. P. Panick, Alexander Boscanin, Khashayar Farsad

Narrative Review of the objective analysis of long-term outcome of the Ponseti technique: experience from Dallas

B. Stephens Richards

Artificial intelligence in single photon emission computed tomography (SPECT) imaging: a narrative review

Wenyi Shao, Steven P. Rowe, Yong Du

Treatment of patch infection after carotid endarterectomy: a systematic review

Tim M. Wikkeling, Senne A. van Gijssel, Maarten J. van der Laan, Clark J. Zeebregts, Ben R. Saleem

Robot-assisted laminectomy in spinal surgery: a systematic review

Zhuofu Li, Guoxin Yu, Shuai Jiang, Lei Hu, Weishi Li

Erratum

Erratum to inhibition of IL-6/JAK/STAT3 pathway rescues denervation-induced skeletal muscle atrophy

Editorial Office

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.