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Interviews with Outstanding Authors (2022)

In 2022, many ATM authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

New Impact Factor for Annals of Translational Medicine: 3.616

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2021 citation year: 3.616.

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

While China’s academic field is flourishing, ATM is blooming and become a choice of publication venue for more and more recognized affiliations. For ATM, it is precisely a type of recognition—by the country's top academic institutions and the most important think tanks in the country in the form of publication venue choice—that makes ATM stay in the scientific research fronts and able to further realize its mission of translating between bench and bedside. ATM's educational value is mostly based on the objective opinions of a group of field experts within the scientific community.

Reviewer of the Month (2022)

In 2022, ATM reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Novel Tools and Therapies for Ocular Regeneration

This special series is very timely since there has been a recent increase in the momentum of translational research in ocular regeneration. This increase stems partially from the success of ocular gene therapy. This special eye series includes review and original articles of novel tools and therapies being developed for ocular regeneration. The goal of this eye series is to provide some overview of the latest research being done in the area of ocular regeneration in order to highlight the broad potential in this field.

Endovascular Interventions in Trauma

Trauma is a leading cause of death and disability and predominately effects young patients. Trauma teams include many health care professionals from many subspecialties. Endovascular specialists such as interventional radiologists and vascular surgeons play an ever growing role in this team and in the care of these patients. In this focused series on endovascular interventions in trauma, articles will discuss the endovascular treatment of traumatic aortic injury, splenic, hepatic, renal pelvic and extremity trauma. Additionally, we include an article on the emerging technology of resuscitative endovascular balloon occlusion of the aorta (REBOA).

Highlights in Anesthesia and Critical Care Medicine (Ongoing)

Guest Editors: Tobias Eckle and Benjamin Scott (Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA)

Challenges in Clinical Trials (Ongoing)

This special series on “Challenges in Clinical Trials” is edited by Dr. Weiping Wen, Dr. Yanhong Deng, Dr. Qian Shi and Dr. Jun (Vivien) Yin. As with any industry, the challenges facing those working in clinical trials are numerous: from patient recruitment, adoption of technology, regulatory requirements, and spiraling costs. This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.

Lung Cancer Management—The Next Decade (Ongoing)

This special series on “Lung Cancer Management—The Next Decade” is edited by Dr. Calvin S. H. Ng. Lung cancer remains a disease associated with high morbidity and mortality. It is only in the past decade or so that newer forms of therapies have gradually become available. Targeted and immunotherapies, specialized radiation ion therapies; and operative approaches that are more tailored to the individual with improved precision and lower surgical trauma have been in rapid development.

ATM Annual Report 2021

Greetings from the editorial office of ATM. We wish you a happy new year in 2022. In 2021, ATM has made great progress under the joint-efforts of experts worldwide.

- More than 1800 papers have been published in ATM in 2021.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,860,685 times in 2021.
- The number of total citations by SCI journals has significantly increased to 36,500 till December 2021.
- The pageviews of ATM journal website is increasing significantly, with a total of 2,869,820 hits in 2021.

Carotid Artery Stenosis and Stroke-Prevention and Treatment Part II

Prevention and treatment of ischemic carotid-related strokes is a research priority. All controversial issues should be addressed to optimize patient outcomes. The current series are the second part of two series on the prevention and treatment of carotid artery stenosis and carotid-related strokes. Hopefully, these two series will help to answer many of the current questions and to resolve some of the controversial issues on the topic.

Annals of Translational Medicine (ATM) is now a member of Committee on Publication Ethics (COPE)

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

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Vol 10, No 18 (September, 2022)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

The role of big data analysis in identifying a relationship between glaucoma and diabetes mellitus

Ein Oh, Yong Hyun Kim, Ik Hee Ryu, Tae Keun Yoo

Annals of Translational Medicine

2022;

(18)

:948

| https://dx.doi.org/10.21037/atm-22-4134

(September 2022)

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Histopathologic evidence of ventilator-induced lung injury in COVID-19

Guangchen Zou, Kaiqing Lin

Annals of Translational Medicine

2022;

(18)

:949

| https://dx.doi.org/10.21037/atm-22-4153

(September 2022)

PDF Full Text (1) COI Form Open Access

Regulatory oversight and ethical concerns surrounding software as medical device (SaMD) and digital twin technology in healthcare

Amos Lal, Johnny Dang, Christoph Nabzdyk, Ognjen Gajic, Vitaly Herasevich

Annals of Translational Medicine

2022;

(18)

:950

| https://dx.doi.org/10.21037/atm-22-4203

(September 2022)

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Mismatch repair deficiency in rectal cancer: an evolving scenario

Federico Longo, Alfredo Carrato

Annals of Translational Medicine

2022;

(18)

:951

| https://dx.doi.org/10.21037/atm-22-3529

(September 2022)

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FOLFOXIRI plus bevacizumab in the treatment of metastatic colorectal cancer patients with unresectable liver metastases

Carlotta Antoniotti, Guglielmo Vetere, Chiara Cremolini

Annals of Translational Medicine

2022;

(18)

:952

| https://dx.doi.org/10.21037/atm-22-3656

(September 2022)

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Is prognosis uniformly excellent in patients with stage II MSI-high colon cancer?

Jane Wang, Georgios Antonios Margonis

Annals of Translational Medicine

2022;

(18)

:953

| https://dx.doi.org/10.21037/atm-22-3481

(September 2022)

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Original Article

Preclinical systematic review & meta-analysis of cyclosporine for the treatment of myocardial ischemia-reperfusion injury

Joshua Hefler, Braulio A. Marfil-Garza, Sandra Campbell, Darren H. Freed, A. M. James Shapiro

Annals of Translational Medicine

2022;

(18)

:954

| https://dx.doi.org/10.21037/atm-22-618

(September 2022)

PDF Full Text (2) Reporting Checklist Peer Review File COI Form Open Access

Importance of computed tomography muscle quality and continuous versus cut-off-based sarcopenia detection in major hepatic surgery

Isabel Molwitz, Marius Kemper, Linda Krause, Gerhard Adam, Jakob Robert Izbicki, Christoph Burdelski, Geraldine de Heer, Laura Gerdes, Jin Yamamura, Jun Li

Annals of Translational Medicine

2022;

(18)

:955

| https://dx.doi.org/10.21037/atm-21-5948

(September 2022)

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Relationship between different skeletal facial types and anterior alveolar bone thickness with cone-beam computed tomography in an Asian population

Baochao Li, Jialing Li, Huijuan Wang, Xiaoqiu Xie, Juan Wen, Huang Li

Annals of Translational Medicine

2022;

(18)

:956

| https://dx.doi.org/10.21037/atm-22-935

(September 2022)

PDF Full Text (2) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Messenger RNA expression profiles and bioinformatics analysis of mouse hippocampi during exercise alleviates methamphetamine dependence via mRNA profile change in hippocampi

Yue Li, Guo-Fen Re, Yu Zhao, Deshenyue Kong, Jun-Hong Mao, Kun-Hua Wang, Yi-Qun Kuang

Annals of Translational Medicine

2022;

(18)

:957

| https://dx.doi.org/10.21037/atm-22-450

(September 2022)

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Visualization and quantification of de novo lipogenesis using a FASN-2A-GLuc mouse model

Wenjiao Li, Song Zhang, Xin Fu, Jiehao Zhang, Renlong Li, Haohao Zhang, Qingling An, Weizhen Wang, Zuhong Tian, Changhong Shi, Yongzhan Nie

Annals of Translational Medicine

2022;

(18)

:958

| https://dx.doi.org/10.21037/atm-22-1132

(September 2022)

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CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma

Hongcheng Zhu, Hui Chen, Guangzong Chen, Ming Liu, Li Chu, Yu Gu, Yun Chen, Chi Zhang, Qin Qin, Yanan Chen, Weiwei Chen, Jianhong Fan, Yongzhan Nie, Junqiang Chen, Shixiu Wu, Xinchen Sun, Weixin Zhao, Kuaile Zhao

Annals of Translational Medicine

2022;

(18)

:959

| https://dx.doi.org/10.21037/atm-21-3630

(September 2022)

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Objective study of the facial parameters of observations in patients with type 2 diabetes mellitus by machine learning

Baozhi Cheng, Jianli Ma, Xiaolong Chen, Lingyan Yuan

Annals of Translational Medicine

2022;

(18)

:960

| https://dx.doi.org/10.21037/atm-22-3580

(September 2022)

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Efficacy and safety of apatinib in advanced refractory soft tissue sarcoma and association with histologic subtypes: a multicenter retrospective study

Xiangling Wang, Jian Wang, Baoyong Sun, Yuping Sun, Ning Liu, Xuecai Niu, Chunhua Li, Li Li, Qiang Zhang, Jing Hao, Xiuwen Wang

Annals of Translational Medicine

2022;

(18)

:961

| https://dx.doi.org/10.21037/atm-22-3250

(September 2022)

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Quantitative iTRAQ proteomics reveal the proteome profiles of bone marrow mesenchymal stem cells after cocultures with Schwann cells in vitro

Han Ding, Ang Li, Chao Sun, Jianping Zhang, Jun Shang, Haoshuai Tang, Junjin Li, Min Wang, Xiaohong Kong, Zhijian Wei, Shiqing Feng

Annals of Translational Medicine

2022;

(18)

:962

| https://dx.doi.org/10.21037/atm-22-3073

(September 2022)

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The lncRNA TERC promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-423-5p to regulate SOX12 expression

Jianhua Wang, Min Wu, Le Chang, Zhankui Jin, Xiaoli Yang, Dongliang Li, Jiaojiao Wang, Jie Qu, Qiang Hou, Xiaoyan Huang, Cuixiang Xu

Annals of Translational Medicine

2022;

(18)

:963

| https://dx.doi.org/10.21037/atm-22-3545

(September 2022)

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Survey on status quo and development needs of research and innovation capabilities of young researchers at university-affiliated hospitals in China: a cross-sectional survey

Jing Xue, Xinyu Chen, Zhuojing Zhang, Yuanyuan Liu, Xing Liu, Weihong Huang, Qun Qin, Song Feng, Hua Guo

Annals of Translational Medicine

2022;

(18)

:964

| https://dx.doi.org/10.21037/atm-22-3692

(September 2022)

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Identification of potential associated factors for stress urinary incontinence in women: a retrospective study

Dongmei Wei, Jian Meng, Yueting Zhang, Yueyue Chen, Jijie Li, Xiaoyu Niu

Annals of Translational Medicine

2022;

(18)

:965

| https://dx.doi.org/10.21037/atm-22-3539

(September 2022)

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Bioinformatics analysis of prognostic value and immune cell infiltration of SERPINA1 gene in cutaneous melanoma

Fangjuan Hu, Ruqi Mei, Haiyan Zhang, Daijun Hao, Wei Li

Annals of Translational Medicine

2022;

(18)

:966

| https://dx.doi.org/10.21037/atm-22-3873

(September 2022)

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Risk factors and prognostic role of renal adverse event in patients receiving immune checkpoint inhibitor therapy: analysis of data from a retrospective cohort study

Zhiyao Bao, Lifeng Luo, Tian Xu, Jin Yang, Mengchen Lv, Lei Ni, Xianwen Sun, Wei Chen, Lin Zhou, Xiaofei Wang, Yi Xiang, Beili Gao

Annals of Translational Medicine

2022;

(18)

:967

| https://dx.doi.org/10.21037/atm-22-3684

(September 2022)

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Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis

Fan-Rui Zeng, Xu-Yang Zhou, Ling-Ge Zeng, Jian-Cong Sun, Fen He, Wei Mo, Yang Wen, Shu-Yu Wang, Qin Liu, Lin-Lang Guo

Annals of Translational Medicine

2022;

(18)

:968

| https://dx.doi.org/10.21037/atm-22-3642

(September 2022)

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Krüppel-like factor 5 promotes the progression of oral squamous cell carcinoma via the baculoviral IAP repeat containing 5 gene

Yuehua Li, Wen Shi, Yajun Shen, Li Xu, Zhigang Cai, Xiaofeng Shan

Annals of Translational Medicine

2022;

(18)

:969

| https://dx.doi.org/10.21037/atm-22-3728

(September 2022)

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Development and validation of a decision tree classification model for the essential hypertension based on serum protein biomarkers

Zongqiang Han, Lina Wen

Annals of Translational Medicine

2022;

(18)

:970

| https://dx.doi.org/10.21037/atm-22-3901

(September 2022)

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Biomimetic cytomembrane-coated ZIF-8-loaded DMDD nanoparticle and sonodynamic co-therapy for cancer

Shuqi Zhao, Meifeng Chen, Zhu Yu, Thi Thai Hoa Pham, Shutian Mo, Yongfei He, Tianyi Liang, Wenlong Cao, Chuangye Han

Annals of Translational Medicine

2022;

(18)

:971

| https://dx.doi.org/10.21037/atm-22-3646

(September 2022)

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Melatonin attenuates acute and chronic itch in mice: the antioxidant and anti-inflammatory effects of melatonin receptors

Li Zhang, Jiang-Tao Zhang, Ya Huang, Guo-Kun Zhou, Yan Zhou, Jiang-Ping Yang, Tong Liu

Annals of Translational Medicine

2022;

(18)

:972

| https://dx.doi.org/10.21037/atm-22-3804

(September 2022)

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Effect of recombinant human brain natriuretic peptide on acute kidney injury after coronary artery bypass grafting: a retrospective comparative cohort study

Ziyao Wang, Yangyan Wei, Junyu Chen, Qian Zhang, Jiwen Tang, Qing Chang

Annals of Translational Medicine

2022;

(18)

:973

| https://dx.doi.org/10.21037/atm-22-3727

(September 2022)

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Analysis of strategy and efficacy clinical treatments of Kümmell disease: a cohort study

Weixing Xu, Weiguo Ding, Xinwei Xu, Hongfeng Sheng, Jiafu Zhu, Long Xin, Bin Xu

Annals of Translational Medicine

2022;

(18)

:974

| https://dx.doi.org/10.21037/atm-22-3801

(September 2022)

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The correlation factors and prognostic significance of coagulation disorders after chimeric antigen receptor T cell therapy in hematological malignancies: a cohort study

Rujiao Dong, Yudi Wang, Yuanyuan Lin, Xiaohong Sun, Chongyun Xing, Yu Zhang, Haizhi Wang, Lihui Dai, Kang Yu, Songfu Jiang

Annals of Translational Medicine

2022;

(18)

:975

| https://dx.doi.org/10.21037/atm-22-3814

(September 2022)

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Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis

Pengdong Li, Shuang Lv, Wenyue Jiang, Lihui Si, Baojian Liao, Guifang Zhao, Ziran Xu, Lina Wang, Jia Zhang, Haitao Wu, Qian Peng, Zhaohui Li, Ling Qi, Guangfan Chi, Yulin Li

Annals of Translational Medicine

2022;

(18)

:976

| https://dx.doi.org/10.21037/atm-22-3912

(September 2022)

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Exploring the molecular mechanism of Sishen Decoction in the treatment of rheumatoid arthritis

Jiannan Zheng, Yeyu Zhao, Qing Qi, Mingli Gao, Jing Yu

Annals of Translational Medicine

2022;

(18)

:977

| https://dx.doi.org/10.21037/atm-22-3888

(September 2022)

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Screening of key pathogenic genes in advanced knee osteoarthritis based on bioinformatics analysis

Yongju Yang, Yuqian Zhang, Dongyu Min, Heshan Yu, Xuefeng Guan

Annals of Translational Medicine

2022;

(18)

:978

| https://dx.doi.org/10.21037/atm-22-3863

(September 2022)

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Podoplanin neutralization reduces thrombo-inflammation in experimental ischemic stroke by inhibiting interferon/caspase-1/GSDMD in microglia

Shuang Qian, Lei Qian, Ye Yang, Jie Cui, Yiming Zhao

Annals of Translational Medicine

2022;

(18)

:979

| https://dx.doi.org/10.21037/atm-22-3970

(September 2022)

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Inhibitory effects of isoliquiritin on an atopic dermatitis model through the CD177/JAK2/STAT pathway in vitro and in vivo

Qing Wu, Xiumei Mo, Ying Lin, Junfeng Liu, Siqi Ye, Yu Zhang, Xingxing Fan, Dacan Chen, Fenggen Yan

Annals of Translational Medicine

2022;

(18)

:980

| https://dx.doi.org/10.21037/atm-22-3989

(September 2022)

PDF Full Text (2) Reporting Checklist Data Sharing Statement COI Form Open Access

Efficacy and safety of apatinib in patients with untreated or chemotherapy-refractory soft tissue sarcoma: a multicenter, phase 2 trial

Wenxi Yu, Hongmei Zhang, Jing Chen, Xing Zhang, Yong Chen, Guofan Qu, Gang Huang, Yuhong Zhou, Ting Ye, Zhengfu Fan, Yang Yao

Annals of Translational Medicine

2022;

(18)

:981

| https://dx.doi.org/10.21037/atm-22-4229

(September 2022)

PDF Full Text (2) Reporting Checklist Data Sharing Statement COI Form Open Access

Regulator of G-protein signaling 1 promotes choroidal neovascularization in age-related macular degeneration

Qi Zhang, Fengbin Zhang, Yangchen Guo, Yanyan Liu, Ningxin Pan, Hong Chen, Ju Huang, Bifan Yu, Aimin Sang

Annals of Translational Medicine

2022;

(18)

:982

| https://dx.doi.org/10.21037/atm-22-3992

(September 2022)

PDF Full Text (2) Reporting Checklist Data Sharing Statement COI Form Open Access

Exploring the mechanism of Shexiang Tongxin dropping pill in the treatment of microvascular angina through network pharmacology and molecular docking

Chen Chang, Yanling Ren, Qiang Su

Annals of Translational Medicine

2022;

(18)

:983

| https://dx.doi.org/10.21037/atm-22-3976

(September 2022)

PDF Full Text (2) Reporting Checklist COI Form Open Access

Evaluation of volume changes following lateral window maxillary sinus floor elevation using Minics software

Hanfei Zhang, Huiting Hu, Cong Li, Yingxin Ye, Mingdeng Rong, Yong Yang

Annals of Translational Medicine

2022;

(18)

:984

| https://dx.doi.org/10.21037/atm-22-3110

(September 2022)

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Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats

Qianyun Nie, Wenjuan Dong, Baoyu Shen, Genmeng Yang, Hao Yu, Ruilin Zhang, Yanxia Peng, Yang Yu, Shijun Hong, Lihua Li

Annals of Translational Medicine

2022;

(18)

:985

| https://dx.doi.org/10.21037/atm-22-4082

(September 2022)

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Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: a retrospective study

Wenqing Liu, Boyuan Zou, Maosheng Tang, Xiangji Li, Mei Huang, Weida Chen, Chengli Miao

Annals of Translational Medicine

2022;

(18)

:986

| https://dx.doi.org/10.21037/atm-22-4222

(September 2022)

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The efficacy of vonoprazan combined with different dose amoxicillin on eradication of Helicobacter pylori: an open, multicenter, randomized clinical study

Yimin Lin, Huimei Xu, Jianwei Yun, Xiaohui Yu, Yuping Shi, Dekui Zhang

Annals of Translational Medicine

2022;

(18)

:987

| https://dx.doi.org/10.21037/atm-22-4133

(September 2022)

PDF Full Text (2) Reporting Checklist Trial Protocol Data Sharing Statement COI Form Open Access

Establishment and validation of an individualized nomogram for survival prediction of primary mediastinal germ cell tumors based on the SEER database

Longzhou Qi, Jiajun Han, Yifan Shi, Ruizhi Wu, Bin Li, Weiqiang Shi, Shaomu Chen

Annals of Translational Medicine

2022;

(18)

:988

| https://dx.doi.org/10.21037/atm-22-4181

(September 2022)

PDF Full Text (2) Reporting Checklist COI Form Open Access

Impact of individualized pharmaceutical care on efficacy and safety of opioid-tolerant outpatients with cancer pain: a multicenter randomized controlled trial

Haiying Ding, Yu Song, Nan Wu, Xiaowei Zheng, Qing Wei, Yancai Sun, Ruixiang Xie, Qing Zhai, Silu Xu, Yajun Qi, Yinghong Wang, Hui Li, Lin Yang, Qing Fan, Qiuling Zhao, Juan Chen, Jing Shi, Cunxian Duan, Qiong Du, Yiwen Zhang, Zhengbo Song, Shuang Fu, Yunfang Cai, Xianhong Huang, Luo Fang, Yuguo Liu, Ping Huang

Annals of Translational Medicine

2022;

(18)

:989

| https://dx.doi.org/10.21037/atm-22-4091

(September 2022)

PDF Full Text (2) Reporting Checklist Trial Protocol Data Sharing Statement COI Form Open Access

High HDAC5 expression correlates with a poor prognosis and the tumor immune microenvironment in gastric cancer

Li Yuan, Can Hu, Pengcheng Yu, Zhehan Bao, Yuhang Xia, Bo Zhang, Yi Wang

Annals of Translational Medicine

2022;

(18)

:990

| https://dx.doi.org/10.21037/atm-22-4325

(September 2022)

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Evaluation of the safety and effectiveness of neoadjuvant combined chemoimmunotherapy in the treatment of locally advanced esophageal squamous cell carcinoma: a retrospective single-arm cohort study

Pinghui Xia, Pan Li, Simeng Wu, Yiqing Wang, Peng Ye, Chong Zhang, Jian Hu, Biniam Kidane, Savvas Lampridis, Jeffrey B. Velotta, Connor J. Wakefield, Linhai Zhu, Luming Wang

Annals of Translational Medicine

2022;

(18)

:991

| https://dx.doi.org/10.21037/atm-22-4268

(September 2022)

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Elevated serum human epididymis protein 4 is associated with disease severity and worse survival in idiopathic pulmonary fibrosis: a cohort study

Mi Tian, Kaifang Meng, Yujuan Gao, Ji Zhang, Miaomiao Xie, Yaqiong Tian, Xiaoqin Liu, Miao Ma, Ying Cai, Hongyan Wu, Jingjing Ding, Jingyu Chen, Hourong Cai

Annals of Translational Medicine

2022;

(18)

:992

| https://dx.doi.org/10.21037/atm-22-4042

(September 2022)

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Hsa_circ_0099630 knockdown induces the proliferation and osteogenic differentiation and attenuates the apoptosis of porphyromonas gingivalis lipopolysaccharide–induced human periodontal ligament fibroblasts

Yaru Wei, Zhengjun Peng

Annals of Translational Medicine

2022;

(18)

:993

| https://dx.doi.org/10.21037/atm-22-4209

(September 2022)

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A cluster randomized controlled trial to evaluate the efficacy of esophageal and gastric cancer screening in mortality reduction in a non-high-incidence area: methodology and initial results

Xiao-Yang Wang, Shu-Zheng Liu, Hui-Fang Xu, Yin Liu, Hong Wang, Rui-Hua Kang, Qiong Chen, Lu-Yao Zhang, Lan-Wei Guo, Li-Yang Zheng, Chun-Ya Liu, Yi-Xian Wang, Yi-Ping Jing, You-Lin Qiao, Bin-Bin Han, Shao-Kai Zhang

Annals of Translational Medicine

2022;

(18)

:994

| https://dx.doi.org/10.21037/atm-22-4052

(September 2022)

PDF Full Text (2) Reporting Checklist Trial Protocol Data Sharing Statement COI Form Open Access

Cost-effectiveness comparisons of enhanced recovery after surgery (ERAS) vs. non-ERAS for esophageal cancer in China: a retrospective comparative cohort study

Meng Zhang, Hong Wang, Xiaoyang Wang, Luyao Zhang, Cong Shen, Caihua Tian, Xiaoxia Xu, Xiang Li, Zongze Li, Shao-Kai Zhang, Bin-Bin Han

Annals of Translational Medicine

2022;

(18)

:995

| https://dx.doi.org/10.21037/atm-22-4169

(September 2022)

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Selection of fertilization strategies for different sperm parameters in vitro fertilization

Lingling Qiu, Jinxiang Wu, Jing Chen, Hui Cao, Jingjing Cai, Xiaolan Huang, Ruiyun Wu, Yuanzhi Xie, Renata Finelli, Yali He, Suzhen Huang, Zhengyao Wang

Annals of Translational Medicine

2022;

(18)

:996

| https://dx.doi.org/10.21037/atm-22-4308

(September 2022)

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Development and validation of a predictive model for in-hospital mortality in patients with sepsis-associated liver injury

Yousheng Liu, Run Sun, Haiyan Jiang, Guiwen Liang, Zhongwei Huang, Lei Qi, Juying Lu

Annals of Translational Medicine

2022;

(18)

:997

| https://dx.doi.org/10.21037/atm-22-4319

(September 2022)

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Effects of high-dose opioid analgesia on survival, pain relief, quality of life and adverse drug reactions in cancer and neuropathic pain patients: a retrospective cohort study in real-world clinical practice

Xing Hao, Yiting Zhou, Yingxian Ling, Hirotsugu Miyoshi, Masahiko Sumitani, Kwok Ying Chan, Hue Jung Park, Zhiying Feng, Yuefeng Rao

Annals of Translational Medicine

2022;

(18)

:998

| https://dx.doi.org/10.21037/atm-22-4242

(September 2022)

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The role of estrogen in circular RNA and metabonomics in a Neisseria gonorrhoeae infection model

Guiyue Cai, Jin Long, Huizhi Yang, Jiahao Xie, Ruitao Zou, Chunchan Zheng, Xiaoxuan Chen, Shuang Liu, Rongyi Chen

Annals of Translational Medicine

2022;

(18)

:999

| https://dx.doi.org/10.21037/atm-22-3127

(September 2022)

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Efficacy of PD-1 inhibitors combined with pegylated liposomal doxorubicin and dacarbazine compared with liposomal doxorubicin and dacarbazine in advanced leiomyosarcoma patients: a retrospective, single-institutional cohort study

Zhichao Tan, Xinyu Wang, Jiayong Liu, Zhengfu Fan, Tian Gao, Chujie Bai, Ruifeng Xue, Shu Li, Lu Zhang

Annals of Translational Medicine

2022;

(18)

:1000

| https://dx.doi.org/10.21037/atm-22-3963

(September 2022)

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Circ_0001658 regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and affects the progress of papillary thyroid carcinoma

Xiaoyu Liu, Congren Wang, Zijian Su, Shaoyang Cai, Qunxiong Pan, Xiangjin Chen

Annals of Translational Medicine

2022;

(18)

:1001

| https://dx.doi.org/10.21037/atm-22-3650

(September 2022)

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The role and mechanism of epidermal growth factor receptor in hemodynamic induction of abdominal aortic aneurysm formation

Leiting Liu, Honglin Wang, Xi Chen, Yangcheng Zhao

Annals of Translational Medicine

2022;

(18)

:1002

| https://dx.doi.org/10.21037/atm-22-3893

(September 2022)

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The pattern of brain metabolism in chronic steno-occlusive cerebral artery disease

Lingyan Meng, Zhaodi Huang, Hui Li

Annals of Translational Medicine

2022;

(18)

:1003

| https://dx.doi.org/10.21037/atm-22-3993

(September 2022)

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Anterior C2–3 fusion with internal fixation for unstable teardrop fracture of the axis: a retrospective cohort study

Heng Wang, Guangdong Chen, Yijie Liu, Xuefeng Li, Weimin Jiang

Annals of Translational Medicine

2022;

(18)

:1004

| https://dx.doi.org/10.21037/atm-22-4020

(September 2022)

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Incidence and mortality of lung cancer in 2018 and the temporal trends from 2010 to 2018 in Henan province, China: a population-based registry study

Yin Liu, Qiong Chen, Lan-Wei Guo, Hui-Fang Xu, Xiao-Yang Wang, Rui-Hua Kang, Lu-Yao Zhang, Hong Wang, Bin-Bin Han, Shao-Kai Zhang

Annals of Translational Medicine

2022;

(18)

:1005

| https://dx.doi.org/10.21037/atm-22-4029

(September 2022)

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High performance of privacy-preserving acute myocardial infarction auxiliary diagnosis based on federated learning: a multicenter retrospective study

Jie Xu, Yu Zhang, Huamin Yu, Bo Lin, Peng Xiang, Te Lin, Huizhe Lu, Guiying Zhang, Dejian Wang, Hong Yuan, Bin Hu, Jun Jiang

Annals of Translational Medicine

2022;

(18)

:1006

| https://dx.doi.org/10.21037/atm-22-4331

(September 2022)

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Frailty index and risk of cardiovascular diseases: a mendelian randomization study

Jun Li, Heng Chen, Wei He, Limin Luo, Xiaogang Guo

Annals of Translational Medicine

2022;

(18)

:1007

| https://dx.doi.org/10.21037/atm-22-4239

(September 2022)

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Inhibitory effect of CUL1 on atherosclerosis through the p53 pathway

Xi Zhang, Youwei Lu, Wei Jiang, Qianhong Yang

Annals of Translational Medicine

2022;

(18)

:1008

| https://dx.doi.org/10.21037/atm-22-4372

(September 2022)

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Amentoflavone inhibits colorectal cancer epithelial-mesenchymal transition via the miR-16-5p/HMGA2/β-catenin pathway

Kai Cai, Yang Yang, Zi-Jian Guo, Rui-Lin Cai, Hiroki Hashida, Hong-Xia Li

Annals of Translational Medicine

2022;

(18)

:1009

| https://dx.doi.org/10.21037/atm-22-3035

(September 2022)

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Identification and verification of a glycolysis-related gene signature for gastric cancer

Yi Liu, Min Wu, Jian Cao, Yaning Zhu, Yu Ma, Yansong Pu, Xueping Huo, Jianhua Wang

Annals of Translational Medicine

2022;

(18)

:1010

| https://dx.doi.org/10.21037/atm-22-3980

(September 2022)

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Molecular imbalance mechanism of skin and blood leucocytes in severe burn patients at different burn times

Anru Liang, Fukui Qiu, Fangxiao Wu, Jiang Ruan, Lijuan Zhu, Yongxian Rong, Junjun Li

Annals of Translational Medicine

2022;

(18)

:1011

| https://dx.doi.org/10.21037/atm-22-3918

(September 2022)

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Incidence and mortality of gastric cancer in 2018 and their trends from 2010 to 2018 in Henan Province, China: results from a provincial population-based cancer registry

Qiong Chen, Chen Cheng, Yin Liu, Lanwei Guo, Huifang Xu, Hong Wang, Xiaoyang Wang, Luyao Zhang, Shaokai Zhang, Binbin Han

Annals of Translational Medicine

2022;

(18)

:1012

| https://dx.doi.org/10.21037/atm-22-4100

(September 2022)

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Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder

Ru-Qiong Wei, Wen-Liang Guo, Yin-Teng Wu, Raquel Alarcòn Rodrìguez, Marìa del Mar Requena Mullor, Yu-Chang Gui, Jian-Wen Xu

Annals of Translational Medicine

2022;

(18)

:1013

| https://dx.doi.org/10.21037/atm-22-4108

(September 2022)

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Molecular mechanism of CD163⁺ tumor-associated macrophage (TAM)-derived exosome-induced cisplatin resistance in ovarian cancer ascites

Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Jinhong Chen, Xiaoqing Guo

Annals of Translational Medicine

2022;

(18)

:1014

| https://dx.doi.org/10.21037/atm-22-4267

(September 2022)

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Analysis of the factors influencing teamwork among oncology nurses based on multigroup structural equation model

Xiaoxia Xu, Sansan Jia, Shaokai Zhang, Xuan Mai, Zhenxue Mao, Binbin Han

Annals of Translational Medicine

2022;

(18)

:1015

| https://dx.doi.org/10.21037/atm-22-4217

(September 2022)

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Comparing the efficacy and safety of tenofovir and adefovir or combined drug treatment for the treatment of chronic hepatitis B infection: a systematic review and meta-analysis

Zeyu Bi, Ling Wang, Huixin Hou, Miao Lu, Wei Wang, Zishuo Li, Chengjiang Liu

Annals of Translational Medicine

2022;

(18)

:1016

| https://dx.doi.org/10.21037/atm-22-3747

(September 2022)

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Exploring biomarkers and transcriptional factors in type 2 diabetes by comprehensive bioinformatics analysis on RNA-Seq and scRNA-Seq data

Yalan Huang, Linkun Cai, Xiu Liu, Yongjun Wu, Qin Xiang, Rong Yu

Annals of Translational Medicine

2022;

(18)

:1017

| https://dx.doi.org/10.21037/atm-22-4303

(September 2022)

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Percutaneous endovenous intervention versus anticoagulation in the treatment of lower extremity deep vein thrombosis: a systematic review and meta-analysis

Guofu Hu, Jian Wang

Annals of Translational Medicine

2022;

(18)

:1018

| https://dx.doi.org/10.21037/atm-22-4334

(September 2022)

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Comparing the efficacy and safety of atomization of traditional Chinese medicine Kai Hou Jian and budesonide suspension in adult acute laryngitis: a randomized control trial

Wei Feng, Hui Chen, Ye Lu, Rui Liu, Meng Yan Yuan, Jie An, Man Li, Lee Suan Chua, Joana Alcoba Kait, Li Xin

Annals of Translational Medicine

2022;

(18)

:1019

| https://dx.doi.org/10.21037/atm-22-4305

(September 2022)

PDF Full Text (3) Reporting Checklist Trial Protocol Data Sharing Statement COI Form Open Access

A finite element analysis of the supportive effect of a new type of rotary support plate on lateral tibial plateau fractures

Shijie Gao, Quan Cheng Yao, Lindan Geng, Jian Lu, Ming Li, Kai An, Guowei Ren, Federico Canavese, Seok Jung Kim, Chukwuweike Gwam, Pengcheng Wang, Dong Ren

Annals of Translational Medicine

2022;

(18)

:1020

| https://dx.doi.org/10.21037/atm-22-4529

(September 2022)

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The cuproptosis-related gene signature serves as a potential prognostic predictor for ovarian cancer using bioinformatics analysis

Xin Sun, Panling Xu, Fengli Zhang, Ting Sun, Haili Jiang, Xinyuan Lu, Mei Zhang, Ping Li

Annals of Translational Medicine

2022;

(18)

:1021

| https://dx.doi.org/10.21037/atm-22-4546

(September 2022)

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Review Article

The role of non-coding RNAs in myocarditis: a narrative review

Wenhu Liu, Jing Hu, Shuai Lu, Zhaohui Wang

Annals of Translational Medicine

2022;

(18)

:1022

| https://dx.doi.org/10.21037/atm-21-6116

(September 2022)

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Research advances in airway remodeling in asthma: a narrative review

Yanmei Huang, Chen Qiu

Annals of Translational Medicine

2022;

(18)

:1023

| https://dx.doi.org/10.21037/atm-22-2835

(September 2022)

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Adeno-associated virus vector-mediated gene therapy for the treatment of ovarian cancer: a literature review

Jiaojiao Zhu, Tiansheng Qin, Linzhen Wei, Fan Chen, Yaoyao Ding, Qianqian Zhang, Yamei Dang

Annals of Translational Medicine

2022;

(18)

:1024

| https://dx.doi.org/10.21037/atm-22-4426

(September 2022)

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Case Report

Diagnosis and treatment of adult Langerhans cell histiocytosis in the rib: a case report and literature review

Xin Li, Xufeng Liu, Daqiang Sun

Annals of Translational Medicine

2022;

(18)

:1025

| https://dx.doi.org/10.21037/atm-22-3601

(September 2022)

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Combination of Type I and II tyrosine kinase inhibitors—avapritinib and sunitinib—in refractory gastrointestinal stromal tumor after failure to multi-line therapy: a case report

Xiaodan Guo, Shaoqing Huang, Yihang Shi, Zhaoming Guan, Sile Chen, Yun Feng, Yanzhe Xia, Xinhua Zhang

Annals of Translational Medicine

2022;

(18)

:1026

| https://dx.doi.org/10.21037/atm-22-3746

(September 2022)

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Sheng-Xue-Xiao-Ban Capsule-induced ischemic colitis and pulmonary embolism in an idiopathic thrombocytopenic purpura patient: a rare case report

Sisi Zhou, Quan Shi, Yanfeng Zheng, Yihan Zhuang, Yiting Lin, Zeyu Huang, Jing Yu

Annals of Translational Medicine

2022;

(18)

:1027

| https://dx.doi.org/10.21037/atm-22-3951

(September 2022)

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Immunochemotherapy includes pembrolizumab for stage IIIB lung squamous cell carcinoma: a case report

Shuliang Zhang, Yizhou Huang, Maohui Chen, Guanglei Huang, Bin Zheng, Chun Chen

Annals of Translational Medicine

2022;

(18)

:1028

| https://dx.doi.org/10.21037/atm-22-3769

(September 2022)

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Successful re-challenge of dabrafenib-trametinib combination therapy in advanced BRAF^V600E-mutant non-small cell lung cancer after previous cytotoxic chemotherapy, targeted therapy, and immunotherapy: a case report

Yaran Xue, Yaqian Ren, Bing Yan, Zhaona Li, Chun Huang

Annals of Translational Medicine

2022;

(18)

:1029

| https://dx.doi.org/10.21037/atm-22-3887

(September 2022)

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iMDT Corner

Anlotinib combined with chemotherapy and immunotherapy for advanced pulmonary sarcomatoid cancer: a case report and literature review

Mei-Na Piao, Xiao-Ting Ma, Pierre Tankere, Chong-Kin Liam, Jin-Li Li, Jian-Ping Wang

Annals of Translational Medicine

2022;

(18)

:1030

| https://dx.doi.org/10.21037/atm-22-4312

(September 2022)

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Editorial Commentary

Sacituzumab govitecan and other antibody-drug conjugates targeting trophoblast cell-surface antigen 2 (Trop-2) in breast cancer

Ashley Matusz-Fisher, Antoinette R. Tan

Annals of Translational Medicine

2022;

(18)

:1031

| https://dx.doi.org/10.21037/atm-22-1892

(September 2022)

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Redox regulation of hybrid metabolic state in breast cancer metastasis

Kuldeep S. Attri, Jun Hyoung Park, Benny Abraham Kaipparettu

Annals of Translational Medicine

2022;

(18)

:1032

| https://dx.doi.org/10.21037/atm-22-3730

(September 2022)

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Insights From the Reporting Guidelines¹

Prof. Diana R. Elbourne: CONSORT for Cluster Randomized Trials and CONSORT for Noninferiority and Equivalence Trials

Kathy J. Du, Grace S. Li, Kaiping Zhang, Yao Lin, Fanghui Yang, Diana R. Elbourne

Annals of Translational Medicine

2022;

(18)

:1033

| https://dx.doi.org/10.21037/atm-2022-42

(September 2022)

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Review Article on Challenges in Clinical Trials²

Novel clinical trial design and analytic methods to tackle challenges in therapeutic development in rare diseases

Yimei Li, Rima Izem

Annals of Translational Medicine

2022;

(18)

:1034

| https://dx.doi.org/10.21037/atm-21-5496

(September 2022)

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Challenges and opportunities in biomarker-driven trials: adaptive randomization

Yeonhee Park

Annals of Translational Medicine

2022;

(18)

:1035

| https://dx.doi.org/10.21037/atm-21-6027

(September 2022)

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Current usage and challenges of master protocols—based on survey results by ASA BIOP oncology methodology working group master protocol sub-team

Xiaoyun Li, Chengxing Lu, Kristine Broglio, Paul Bycott, Jie Chen, Qi Jiang, Jianchang Lin, Jingjing Ye, Jun Yin

Annals of Translational Medicine

2022;

(18)

:1036

| https://dx.doi.org/10.21037/atm-21-6139

(September 2022)

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Sources of bias for single-arm phase II cancer clinical trials

Sin-Ho Jung

Annals of Translational Medicine

2022;

(18)

:1037

| https://dx.doi.org/10.21037/atm-21-6808

(September 2022)

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Challenges, opportunities, and innovative statistical designs for precision oncology trials

Jun Yin, Shihao Shen, Qian Shi

Annals of Translational Medicine

2022;

(18)

:1038

| https://dx.doi.org/10.21037/atm-22-356

(September 2022)

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Letter to the Editor on Challenges in Clinical Trials²

The promises and challenges of pragmatism: lesson from of a recent clinical trial

Xiaoxi Yao, Peter A. Noseworthy

Annals of Translational Medicine

2022;

(18)

:1039

| https://dx.doi.org/10.21037/atm-21-5424

(September 2022)

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Erratum

Erratum to vasohibin 2 promotes lymphangiogenesis of lung squamous cell carcinoma through snail-dependent vascular endothelial growth factor-D (VEGF-D) signaling pathway

Editorial Office

Annals of Translational Medicine

2022;

(18)

:1040

| https://dx.doi.org/10.21037/atm-2022-45

(September 2022)

PDF Full Text (4) Open Access

Erratum to design and optimization of auditory prostheses using the finite element method: a narrative review

Editorial Office

Annals of Translational Medicine

2022;

(18)

:1041

| https://dx.doi.org/10.21037/atm-2022-47

(September 2022)

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Erratum to epigenetic hypomethylation and upregulation of GD3s in triple negative breast cancer

Editorial Office

Annals of Translational Medicine

2022;

(18)

:1042

| https://dx.doi.org/10.21037/atm-2022-48

(September 2022)

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Disclosure:

1. The series “Insights from the Reporting Guidelines” was commissioned by the editorial office, Annals of Translational Medicine without any funding or sponsorship.

2. The series “Challenges in Clinical Trials” was commissioned by the editorial office, Annals of Translational Medicine without any funding or sponsorship. Yanhong Deng, Qian Shi and Jun (Vivien) Yin served as the unpaid Guest Editors for the series.

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Performance of the AIDRScreening system in detecting diabetic retinopathy in the fundus photographs of Chinese patients: a prospective, multicenter, clinical study

Yao Yang, Jianying Pan, Miner Yuan, Kunbei Lai, Huirui Xie, Li Ma, Suzhong Xu, Ruzhi Deng, Mingwei Zhao, Yan Luo, Xiaofeng Lin

Sodium Danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and tuberous sclerosis complex-2 (TSC2)/mammalian target of rapamycin (mTOR) pathways

Shengzhao Hu, Yingli Chen, Shipeng Huang, Min Liu, Ying Liu, Shaofang Huang

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Twelve-week high-fat diet for improving adverse ventricular remodeling post-myocardial infarction by alleviating local inflammation

Jing Yang, Bifang Mai, Yinqing Su, Shumin Liang, Zizhuo Su, Yuyang Chen, Shuanglun Xie

High expression of the ANXA3 gene promotes immune infiltration and improves tumor prognosis in ovarian serous carcinoma using bioinformatics analyses

De-Qiang Li, Mao Lin, Zeinab Abdelrahman

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Causal effects of serum sex hormone binding protein levels on the risk of amyotrophic lateral sclerosis: a mendelian randomization study

Ya-Nan Ou, Liu Yang, Bang-Sheng Wu, Lan Tan, Jin-Tai Yu

Pre-stroke dementia and in-hospital outcomes in the Chinese Stroke Center Alliance

Chelsea Liu, Hong-Qiu Gu, Xin Yang, Chun-Juan Wang, Xia Meng, Kai-Xuan Yang, Yun-Yun Xiong, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Yong-Jun Wang, Zi-Xiao Li

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Identifying and validating key genes mediating intracranial aneurysm rupture using weighted correlation network analysis and exploration of personalized treatment

Ji Wu, Zhi-Jun Chen, Jing Liang, Chang-Sheng Lai, Xue-Yu Li, Zhao-Jian Yang

Smoke analysis of a new surgical system that applies low-temperature plasma

Boya Zhang, Qingyu Guan, Yunsheng Zhu, Jingjin Zhu, Xiaohan Liu, Shuaiqi Li, Rungong Yang, Xiru Li

Bergenin inhibits palmitic acid-induced pancreatic β-cell inflammatory death via regulating NLRP3 inflammasome activation

Donghong Lei, Yanru Sun, Jie Liu, Jianxiu Chi

Mesenchymal stem cells alleviate aging in vitro and in vivo

Qun Liu, Shaole Song, Lei Song, Youkun Bi, Keqi Zhu, Xinlong Qiao, Huiwen Wang, Chao Gao, Hong Cai, Guangju Ji

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Identification and validation of a 9-gene signature for the prognosis of ovarian cancer by integrated bioinformatical analysis

Siping Chen, Man Yang, Haikun Yang, Qiaofei Tang, Chunming Gu, Weifeng Wei

Exploration of immune infiltration and feature genes in viral hepatitis-associated liver fibrosis using transcriptome data

Jiali Pan, Yu Tian, Fengling Hu, Jinghang Xu, Ning Tan, Yifan Han, Qian Kang, Hongyu Chen, Yuqing Yang, Xiaoyuan Xu

Correlation between gut bacteria Phascolarctobacterium and exogenous metabolite α-linolenic acid in T2DM: a case-control study

Weidong Li, Lisha Li, Fujie Yang, Qiongying Hu, Daqian Xiong

Comparison of robot-assisted vitreoretinal surgery and manual surgery in different preclinical settings: a randomized trial

Ting Wang, Jun Xia, Ling Jin, Danqi Zeng, Pisong Yan, Shengzhi Lin, Kai Huang, Haotian Lin

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Mortality and prognostic factors in hospitalized COVID-19 patients with cancer: an analysis from a large healthcare system in the United States

Luis E. Raez, Meri Tarockoff, Carlos Rodrigo Carracedo Uribe, Jianli Niu, Candice Sareli, Nithya Sundararaman, Jayme Ion, Paula Eckardt, Andres Alvarez-Pinzon, Atif Hussein

Nicotinic acid supplementation contributes to the amelioration of Alzheimer’s disease in mouse models

Zhigang Wang, Zhenyou Zou, Qinghua Li

Long-term effects of vitamin D on exacerbation rate, health care utilization and lung function in children with asthma

Qinyuan Li, Qi Zhou, Guangli Zhang, Xiaoyin Tian, Yaolong Chen, Yupeng Cun, Ximing Xu, Zhengxiu Luo

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

Identification of hub genes and infiltrating immune cells in skeletal muscle in obesity

Shuoshuo Jin, Jinya Huang, Kuangyang Chen, Xuanchun Wang

Development and validation of the diagnostic accuracy of artificial intelligence-assisted ultrasound in the classification of splenic trauma

Xue Jiang, Yukun Luo, Xuelei He, Kun Wang, Wenjing Song, Qinggui Ye, Lei Feng, Wei Wang, Xiaojuan Hu, Hua Li

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

Particle beam radiation therapy for head and neck rhabdomyosarcoma in adults

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxing Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

SMC4 enhances the chemoresistance of hepatoma cells by promoting autophagy

Shi-Ran Zhang, Jie Li, Jing-Xiang Chen, Geng Chen, Jun-Ying Chen, Hang-Wei Fu, Bo Zhou

Review Article

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

Uniportal pure robotic-assisted thoracic surgery—technical aspects, tips and tricks

Diego Gonzalez-Rivas, Veronica Manolache, Mugurel Liviu Bosinceanu, Javier Gallego-Poveda, Alejandro Garcia-Perez, Mercedes de la Torre, Akif Turna, Natalia Motas

A narrative review on the association of high intraocular pressure and glaucoma in patients with retinal vein occlusion

Sayena Jabbehdari, Ghasem Yazdanpanah, Louis B. Cantor, Amir Reza Hajrasouliha

Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis

Jiayu Li, Qi Wang, Honghao Wang

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review

Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu

Optimal validation of accuracy in antibody assays and reasonable definition of antibody positive/negative subgroups in neuroimmune diseases: a narrative review

Hai-Feng Li

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Reflections from a NMOSD case with serum AQP4-Ab negativity but CSF positivity: narrative review of how to interpret AQP4-Ab test results

Qun Xue, Shugang Cao, Qianyun Rui

Cone-beam CT in lung biopsy: a clinical practice review on lessons learned and future perspectives

Roel L. J. Verhoeven, Stephan E. P. Kops, Inge N. Wijma, Desi K. M. ter Woerds, Erik H. F. M. van der Heijden

Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology

Weihua Zhang, Haitao Ren, Xiaotun Ren, Fang Fang, Hongzhi Guan

Mending a broken heart—targeting cardiomyocyte regeneration: a literature review

Chunna Jin, Shiyu Zhu, Tingting Zhao, Jiewen Deng, Meixiang Xiang, Hong Ma

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Narrative review of autoantibodies in idiopathic inflammatory myopathies

Yilin Liu, Yiming Zheng, Hongjun Hao, Yun Yuan

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Focal cryotherapy for prostate cancer: a contemporary literature review

Srinath Kotamarti, Thomas J. Polascik

Patient-specific airway stent using three-dimensional printing: a review

Carlos Aravena, Thomas R. Gildea

Editorial

Next steps in precision approaches for asthma-proteomics and asthma endotypes

Allan R. Brasier

Shining a light on foveal development after congenital cataract surgery

Annegret Dahlmann-Noor, Maryse Bailly

Mesenchymal stem cells: an early yet promising prospect for Asthma

Mariela Villarreal, Alvaro Moreira

Editorial Commentary

Tumor heterogeneity and the dilemma of antioxidant therapies in cancer

Heloisa Sobreiro Selistre-de-Araujo, Bianca Cruz Pachane, Wanessa Fernanda Altei

Letter to the Editor

Letter to the editor regarding “decompression alone versus decompression plus fusion for lumbar spinal stenosis with degenerative spondylolisthesis”: when do we have enough evidence?

Pravesh S. Gadjradj, Fabian Sommer, Rodrigo Navarro-Ramirez

Erratum

Erratum to the effects of a biodegradable Mg-based alloy on the function of VSMCs via immunoregulation of macrophage

Editorial Office

Erratum to clostridium butyricum alleviates dextran sulfate sodium-induced experimental colitis and promotes intestinal lymphatic vessel regeneration in mice

Editorial Office

Erratum to miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1

Editorial Office

Retraction

Retraction: application of hybrid particle swarm and ant colony optimization algorithms to obtain the optimum homomorphic wavelet image fusion

Yonghong Jiang, Yaning Ma

Retraction to artesunate induces apoptosis and inhibits the proliferation, stemness, and tumorigenesis of leukemia

Shengmei Chen, Silin Gan, Lijie Han, Xue Li, Xiaoqing Xie, Dianbin Zou, Hui Sun

Insights From the Reporting Guidelines

Prof. Karin Hannes: COREQ (Consolidated Criteria for Reporting Qualitative Studies)

Kathy J. Du, Grace S. Li, Kaiping Zhang, Yao Lin, Fanghui Yang, Karin Hannes

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

Over the year, many ATM reviewers have made outstanding contributions to the peer review process. More >>

Announcement more

New Impact Factor for Annals of Translational Medicine: 3.616

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2021 citation year: 3.616. More >>

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

From bud to blossom: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in Annals of Translational... More >>

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