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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

The role of big data analysis in identifying a relationship between glaucoma and diabetes mellitus
Ein Oh, Yong Hyun Kim, Ik Hee Ryu, Tae Keun Yoo
Annals of Translational Medicine
 2022;
10
(18)
:948
Histopathologic evidence of ventilator-induced lung injury in COVID-19
Guangchen Zou, Kaiqing Lin
Annals of Translational Medicine
 2022;
10
(18)
:949
Regulatory oversight and ethical concerns surrounding software as medical device (SaMD) and digital twin technology in healthcare
Amos Lal, Johnny Dang, Christoph Nabzdyk, Ognjen Gajic, Vitaly Herasevich
Annals of Translational Medicine
 2022;
10
(18)
:950
Mismatch repair deficiency in rectal cancer: an evolving scenario
Federico Longo, Alfredo Carrato
Annals of Translational Medicine
 2022;
10
(18)
:951
FOLFOXIRI plus bevacizumab in the treatment of metastatic colorectal cancer patients with unresectable liver metastases
Carlotta Antoniotti, Guglielmo Vetere, Chiara Cremolini
Annals of Translational Medicine
 2022;
10
(18)
:952
Is prognosis uniformly excellent in patients with stage II MSI-high colon cancer?
Jane Wang, Georgios Antonios Margonis
Annals of Translational Medicine
 2022;
10
(18)
:953

Original Article

Preclinical systematic review & meta-analysis of cyclosporine for the treatment of myocardial ischemia-reperfusion injury
Joshua Hefler, Braulio A. Marfil-Garza, Sandra Campbell, Darren H. Freed, A. M. James Shapiro
Annals of Translational Medicine
 2022;
10
(18)
:954
Importance of computed tomography muscle quality and continuous versus cut-off-based sarcopenia detection in major hepatic surgery
Isabel Molwitz, Marius Kemper, Linda Krause, Gerhard Adam, Jakob Robert Izbicki, Christoph Burdelski, Geraldine de Heer, Laura Gerdes, Jin Yamamura, Jun Li
Annals of Translational Medicine
 2022;
10
(18)
:955
Relationship between different skeletal facial types and anterior alveolar bone thickness with cone-beam computed tomography in an Asian population
Baochao Li, Jialing Li, Huijuan Wang, Xiaoqiu Xie, Juan Wen, Huang Li
Annals of Translational Medicine
 2022;
10
(18)
:956
Messenger RNA expression profiles and bioinformatics analysis of mouse hippocampi during exercise alleviates methamphetamine dependence via mRNA profile change in hippocampi
Yue Li, Guo-Fen Re, Yu Zhao, Deshenyue Kong, Jun-Hong Mao, Kun-Hua Wang, Yi-Qun Kuang
Annals of Translational Medicine
 2022;
10
(18)
:957
Visualization and quantification of de novo lipogenesis using a FASN-2A-GLuc mouse model
Wenjiao Li, Song Zhang, Xin Fu, Jiehao Zhang, Renlong Li, Haohao Zhang, Qingling An, Weizhen Wang, Zuhong Tian, Changhong Shi, Yongzhan Nie
Annals of Translational Medicine
 2022;
10
(18)
:958
CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma
Hongcheng Zhu, Hui Chen, Guangzong Chen, Ming Liu, Li Chu, Yu Gu, Yun Chen, Chi Zhang, Qin Qin, Yanan Chen, Weiwei Chen, Jianhong Fan, Yongzhan Nie, Junqiang Chen, Shixiu Wu, Xinchen Sun, Weixin Zhao, Kuaile Zhao
Annals of Translational Medicine
 2022;
10
(18)
:959
Objective study of the facial parameters of observations in patients with type 2 diabetes mellitus by machine learning
Baozhi Cheng, Jianli Ma, Xiaolong Chen, Lingyan Yuan
Annals of Translational Medicine
 2022;
10
(18)
:960
Efficacy and safety of apatinib in advanced refractory soft tissue sarcoma and association with histologic subtypes: a multicenter retrospective study
Xiangling Wang, Jian Wang, Baoyong Sun, Yuping Sun, Ning Liu, Xuecai Niu, Chunhua Li, Li Li, Qiang Zhang, Jing Hao, Xiuwen Wang
Annals of Translational Medicine
 2022;
10
(18)
:961
Quantitative iTRAQ proteomics reveal the proteome profiles of bone marrow mesenchymal stem cells after cocultures with Schwann cells in vitro
Han Ding, Ang Li, Chao Sun, Jianping Zhang, Jun Shang, Haoshuai Tang, Junjin Li, Min Wang, Xiaohong Kong, Zhijian Wei, Shiqing Feng
Annals of Translational Medicine
 2022;
10
(18)
:962
The lncRNA TERC promotes gastric cancer cell proliferation, migration, and invasion by sponging miR-423-5p to regulate SOX12 expression
Jianhua Wang, Min Wu, Le Chang, Zhankui Jin, Xiaoli Yang, Dongliang Li, Jiaojiao Wang, Jie Qu, Qiang Hou, Xiaoyan Huang, Cuixiang Xu
Annals of Translational Medicine
 2022;
10
(18)
:963
Survey on status quo and development needs of research and innovation capabilities of young researchers at university-affiliated hospitals in China: a cross-sectional survey
Jing Xue, Xinyu Chen, Zhuojing Zhang, Yuanyuan Liu, Xing Liu, Weihong Huang, Qun Qin, Song Feng, Hua Guo
Annals of Translational Medicine
 2022;
10
(18)
:964
Identification of potential associated factors for stress urinary incontinence in women: a retrospective study
Dongmei Wei, Jian Meng, Yueting Zhang, Yueyue Chen, Jijie Li, Xiaoyu Niu
Annals of Translational Medicine
 2022;
10
(18)
:965
Bioinformatics analysis of prognostic value and immune cell infiltration of SERPINA1 gene in cutaneous melanoma
Fangjuan Hu, Ruqi Mei, Haiyan Zhang, Daijun Hao, Wei Li
Annals of Translational Medicine
 2022;
10
(18)
:966
Risk factors and prognostic role of renal adverse event in patients receiving immune checkpoint inhibitor therapy: analysis of data from a retrospective cohort study
Zhiyao Bao, Lifeng Luo, Tian Xu, Jin Yang, Mengchen Lv, Lei Ni, Xianwen Sun, Wei Chen, Lin Zhou, Xiaofei Wang, Yi Xiang, Beili Gao
Annals of Translational Medicine
 2022;
10
(18)
:967
Identification of key genes and pathway related to chemoresistance of small cell lung cancer through an integrative bioinformatics analysis
Fan-Rui Zeng, Xu-Yang Zhou, Ling-Ge Zeng, Jian-Cong Sun, Fen He, Wei Mo, Yang Wen, Shu-Yu Wang, Qin Liu, Lin-Lang Guo
Annals of Translational Medicine
 2022;
10
(18)
:968
Krüppel-like factor 5 promotes the progression of oral squamous cell carcinoma via the baculoviral IAP repeat containing 5 gene
Yuehua Li, Wen Shi, Yajun Shen, Li Xu, Zhigang Cai, Xiaofeng Shan
Annals of Translational Medicine
 2022;
10
(18)
:969
Development and validation of a decision tree classification model for the essential hypertension based on serum protein biomarkers
Zongqiang Han, Lina Wen
Annals of Translational Medicine
 2022;
10
(18)
:970
Biomimetic cytomembrane-coated ZIF-8-loaded DMDD nanoparticle and sonodynamic co-therapy for cancer
Shuqi Zhao, Meifeng Chen, Zhu Yu, Thi Thai Hoa Pham, Shutian Mo, Yongfei He, Tianyi Liang, Wenlong Cao, Chuangye Han
Annals of Translational Medicine
 2022;
10
(18)
:971
Melatonin attenuates acute and chronic itch in mice: the antioxidant and anti-inflammatory effects of melatonin receptors
Li Zhang, Jiang-Tao Zhang, Ya Huang, Guo-Kun Zhou, Yan Zhou, Jiang-Ping Yang, Tong Liu
Annals of Translational Medicine
 2022;
10
(18)
:972
Effect of recombinant human brain natriuretic peptide on acute kidney injury after coronary artery bypass grafting: a retrospective comparative cohort study
Ziyao Wang, Yangyan Wei, Junyu Chen, Qian Zhang, Jiwen Tang, Qing Chang
Annals of Translational Medicine
 2022;
10
(18)
:973
Analysis of strategy and efficacy clinical treatments of Kümmell disease: a cohort study
Weixing Xu, Weiguo Ding, Xinwei Xu, Hongfeng Sheng, Jiafu Zhu, Long Xin, Bin Xu
Annals of Translational Medicine
 2022;
10
(18)
:974
The correlation factors and prognostic significance of coagulation disorders after chimeric antigen receptor T cell therapy in hematological malignancies: a cohort study
Rujiao Dong, Yudi Wang, Yuanyuan Lin, Xiaohong Sun, Chongyun Xing, Yu Zhang, Haizhi Wang, Lihui Dai, Kang Yu, Songfu Jiang
Annals of Translational Medicine
 2022;
10
(18)
:975
Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis
Pengdong Li, Shuang Lv, Wenyue Jiang, Lihui Si, Baojian Liao, Guifang Zhao, Ziran Xu, Lina Wang, Jia Zhang, Haitao Wu, Qian Peng, Zhaohui Li, Ling Qi, Guangfan Chi, Yulin Li
Annals of Translational Medicine
 2022;
10
(18)
:976
Exploring the molecular mechanism of Sishen Decoction in the treatment of rheumatoid arthritis
Jiannan Zheng, Yeyu Zhao, Qing Qi, Mingli Gao, Jing Yu
Annals of Translational Medicine
 2022;
10
(18)
:977
Screening of key pathogenic genes in advanced knee osteoarthritis based on bioinformatics analysis
Yongju Yang, Yuqian Zhang, Dongyu Min, Heshan Yu, Xuefeng Guan
Annals of Translational Medicine
 2022;
10
(18)
:978
Podoplanin neutralization reduces thrombo-inflammation in experimental ischemic stroke by inhibiting interferon/caspase-1/GSDMD in microglia
Shuang Qian, Lei Qian, Ye Yang, Jie Cui, Yiming Zhao
Annals of Translational Medicine
 2022;
10
(18)
:979
Inhibitory effects of isoliquiritin on an atopic dermatitis model through the CD177/JAK2/STAT pathway in vitro and in vivo
Qing Wu, Xiumei Mo, Ying Lin, Junfeng Liu, Siqi Ye, Yu Zhang, Xingxing Fan, Dacan Chen, Fenggen Yan
Annals of Translational Medicine
 2022;
10
(18)
:980
Efficacy and safety of apatinib in patients with untreated or chemotherapy-refractory soft tissue sarcoma: a multicenter, phase 2 trial
Wenxi Yu, Hongmei Zhang, Jing Chen, Xing Zhang, Yong Chen, Guofan Qu, Gang Huang, Yuhong Zhou, Ting Ye, Zhengfu Fan, Yang Yao
Annals of Translational Medicine
 2022;
10
(18)
:981
Regulator of G-protein signaling 1 promotes choroidal neovascularization in age-related macular degeneration
Qi Zhang, Fengbin Zhang, Yangchen Guo, Yanyan Liu, Ningxin Pan, Hong Chen, Ju Huang, Bifan Yu, Aimin Sang
Annals of Translational Medicine
 2022;
10
(18)
:982
Exploring the mechanism of Shexiang Tongxin dropping pill in the treatment of microvascular angina through network pharmacology and molecular docking
Chen Chang, Yanling Ren, Qiang Su
Annals of Translational Medicine
 2022;
10
(18)
:983
Evaluation of volume changes following lateral window maxillary sinus floor elevation using Minics software
Hanfei Zhang, Huiting Hu, Cong Li, Yingxin Ye, Mingdeng Rong, Yong Yang
Annals of Translational Medicine
 2022;
10
(18)
:984
Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats
Qianyun Nie, Wenjuan Dong, Baoyu Shen, Genmeng Yang, Hao Yu, Ruilin Zhang, Yanxia Peng, Yang Yu, Shijun Hong, Lihua Li
Annals of Translational Medicine
 2022;
10
(18)
:985
Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: a retrospective study
Wenqing Liu, Boyuan Zou, Maosheng Tang, Xiangji Li, Mei Huang, Weida Chen, Chengli Miao
Annals of Translational Medicine
 2022;
10
(18)
:986
The efficacy of vonoprazan combined with different dose amoxicillin on eradication of Helicobacter pylori: an open, multicenter, randomized clinical study
Yimin Lin, Huimei Xu, Jianwei Yun, Xiaohui Yu, Yuping Shi, Dekui Zhang
Annals of Translational Medicine
 2022;
10
(18)
:987
Establishment and validation of an individualized nomogram for survival prediction of primary mediastinal germ cell tumors based on the SEER database
Longzhou Qi, Jiajun Han, Yifan Shi, Ruizhi Wu, Bin Li, Weiqiang Shi, Shaomu Chen
Annals of Translational Medicine
 2022;
10
(18)
:988
Impact of individualized pharmaceutical care on efficacy and safety of opioid-tolerant outpatients with cancer pain: a multicenter randomized controlled trial
Haiying Ding, Yu Song, Nan Wu, Xiaowei Zheng, Qing Wei, Yancai Sun, Ruixiang Xie, Qing Zhai, Silu Xu, Yajun Qi, Yinghong Wang, Hui Li, Lin Yang, Qing Fan, Qiuling Zhao, Juan Chen, Jing Shi, Cunxian Duan, Qiong Du, Yiwen Zhang, Zhengbo Song, Shuang Fu, Yunfang Cai, Xianhong Huang, Luo Fang, Yuguo Liu, Ping Huang
Annals of Translational Medicine
 2022;
10
(18)
:989
High HDAC5 expression correlates with a poor prognosis and the tumor immune microenvironment in gastric cancer
Li Yuan, Can Hu, Pengcheng Yu, Zhehan Bao, Yuhang Xia, Bo Zhang, Yi Wang
Annals of Translational Medicine
 2022;
10
(18)
:990
Evaluation of the safety and effectiveness of neoadjuvant combined chemoimmunotherapy in the treatment of locally advanced esophageal squamous cell carcinoma: a retrospective single-arm cohort study
Pinghui Xia, Pan Li, Simeng Wu, Yiqing Wang, Peng Ye, Chong Zhang, Jian Hu, Biniam Kidane, Savvas Lampridis, Jeffrey B. Velotta, Connor J. Wakefield, Linhai Zhu, Luming Wang
Annals of Translational Medicine
 2022;
10
(18)
:991
Elevated serum human epididymis protein 4 is associated with disease severity and worse survival in idiopathic pulmonary fibrosis: a cohort study
Mi Tian, Kaifang Meng, Yujuan Gao, Ji Zhang, Miaomiao Xie, Yaqiong Tian, Xiaoqin Liu, Miao Ma, Ying Cai, Hongyan Wu, Jingjing Ding, Jingyu Chen, Hourong Cai
Annals of Translational Medicine
 2022;
10
(18)
:992
Hsa_circ_0099630 knockdown induces the proliferation and osteogenic differentiation and attenuates the apoptosis of porphyromonas gingivalis lipopolysaccharide–induced human periodontal ligament fibroblasts
Yaru Wei, Zhengjun Peng
Annals of Translational Medicine
 2022;
10
(18)
:993
A cluster randomized controlled trial to evaluate the efficacy of esophageal and gastric cancer screening in mortality reduction in a non-high-incidence area: methodology and initial results
Xiao-Yang Wang, Shu-Zheng Liu, Hui-Fang Xu, Yin Liu, Hong Wang, Rui-Hua Kang, Qiong Chen, Lu-Yao Zhang, Lan-Wei Guo, Li-Yang Zheng, Chun-Ya Liu, Yi-Xian Wang, Yi-Ping Jing, You-Lin Qiao, Bin-Bin Han, Shao-Kai Zhang
Annals of Translational Medicine
 2022;
10
(18)
:994
Cost-effectiveness comparisons of enhanced recovery after surgery (ERAS) vs. non-ERAS for esophageal cancer in China: a retrospective comparative cohort study
Meng Zhang, Hong Wang, Xiaoyang Wang, Luyao Zhang, Cong Shen, Caihua Tian, Xiaoxia Xu, Xiang Li, Zongze Li, Shao-Kai Zhang, Bin-Bin Han
Annals of Translational Medicine
 2022;
10
(18)
:995
Selection of fertilization strategies for different sperm parameters in vitro fertilization
Lingling Qiu, Jinxiang Wu, Jing Chen, Hui Cao, Jingjing Cai, Xiaolan Huang, Ruiyun Wu, Yuanzhi Xie, Renata Finelli, Yali He, Suzhen Huang, Zhengyao Wang
Annals of Translational Medicine
 2022;
10
(18)
:996
Development and validation of a predictive model for in-hospital mortality in patients with sepsis-associated liver injury
Yousheng Liu, Run Sun, Haiyan Jiang, Guiwen Liang, Zhongwei Huang, Lei Qi, Juying Lu
Annals of Translational Medicine
 2022;
10
(18)
:997
Effects of high-dose opioid analgesia on survival, pain relief, quality of life and adverse drug reactions in cancer and neuropathic pain patients: a retrospective cohort study in real-world clinical practice
Xing Hao, Yiting Zhou, Yingxian Ling, Hirotsugu Miyoshi, Masahiko Sumitani, Kwok Ying Chan, Hue Jung Park, Zhiying Feng, Yuefeng Rao
Annals of Translational Medicine
 2022;
10
(18)
:998
The role of estrogen in circular RNA and metabonomics in a Neisseria gonorrhoeae infection model
Guiyue Cai, Jin Long, Huizhi Yang, Jiahao Xie, Ruitao Zou, Chunchan Zheng, Xiaoxuan Chen, Shuang Liu, Rongyi Chen
Annals of Translational Medicine
 2022;
10
(18)
:999
Efficacy of PD-1 inhibitors combined with pegylated liposomal doxorubicin and dacarbazine compared with liposomal doxorubicin and dacarbazine in advanced leiomyosarcoma patients: a retrospective, single-institutional cohort study
Zhichao Tan, Xinyu Wang, Jiayong Liu, Zhengfu Fan, Tian Gao, Chujie Bai, Ruifeng Xue, Shu Li, Lu Zhang
Annals of Translational Medicine
 2022;
10
(18)
:1000
Circ_0001658 regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and affects the progress of papillary thyroid carcinoma
Xiaoyu Liu, Congren Wang, Zijian Su, Shaoyang Cai, Qunxiong Pan, Xiangjin Chen
Annals of Translational Medicine
 2022;
10
(18)
:1001
The role and mechanism of epidermal growth factor receptor in hemodynamic induction of abdominal aortic aneurysm formation
Leiting Liu, Honglin Wang, Xi Chen, Yangcheng Zhao
Annals of Translational Medicine
 2022;
10
(18)
:1002
The pattern of brain metabolism in chronic steno-occlusive cerebral artery disease
Lingyan Meng, Zhaodi Huang, Hui Li
Annals of Translational Medicine
 2022;
10
(18)
:1003
Anterior C2–3 fusion with internal fixation for unstable teardrop fracture of the axis: a retrospective cohort study
Heng Wang, Guangdong Chen, Yijie Liu, Xuefeng Li, Weimin Jiang
Annals of Translational Medicine
 2022;
10
(18)
:1004
Incidence and mortality of lung cancer in 2018 and the temporal trends from 2010 to 2018 in Henan province, China: a population-based registry study
Yin Liu, Qiong Chen, Lan-Wei Guo, Hui-Fang Xu, Xiao-Yang Wang, Rui-Hua Kang, Lu-Yao Zhang, Hong Wang, Bin-Bin Han, Shao-Kai Zhang
Annals of Translational Medicine
 2022;
10
(18)
:1005
High performance of privacy-preserving acute myocardial infarction auxiliary diagnosis based on federated learning: a multicenter retrospective study
Jie Xu, Yu Zhang, Huamin Yu, Bo Lin, Peng Xiang, Te Lin, Huizhe Lu, Guiying Zhang, Dejian Wang, Hong Yuan, Bin Hu, Jun Jiang
Annals of Translational Medicine
 2022;
10
(18)
:1006
Frailty index and risk of cardiovascular diseases: a mendelian randomization study
Jun Li, Heng Chen, Wei He, Limin Luo, Xiaogang Guo
Annals of Translational Medicine
 2022;
10
(18)
:1007
Inhibitory effect of CUL1 on atherosclerosis through the p53 pathway
Xi Zhang, Youwei Lu, Wei Jiang, Qianhong Yang
Annals of Translational Medicine
 2022;
10
(18)
:1008
Amentoflavone inhibits colorectal cancer epithelial-mesenchymal transition via the miR-16-5p/HMGA2/β-catenin pathway
Kai Cai, Yang Yang, Zi-Jian Guo, Rui-Lin Cai, Hiroki Hashida, Hong-Xia Li
Annals of Translational Medicine
 2022;
10
(18)
:1009
Identification and verification of a glycolysis-related gene signature for gastric cancer
Yi Liu, Min Wu, Jian Cao, Yaning Zhu, Yu Ma, Yansong Pu, Xueping Huo, Jianhua Wang
Annals of Translational Medicine
 2022;
10
(18)
:1010
Molecular imbalance mechanism of skin and blood leucocytes in severe burn patients at different burn times
Anru Liang, Fukui Qiu, Fangxiao Wu, Jiang Ruan, Lijuan Zhu, Yongxian Rong, Junjun Li
Annals of Translational Medicine
 2022;
10
(18)
:1011
Incidence and mortality of gastric cancer in 2018 and their trends from 2010 to 2018 in Henan Province, China: results from a provincial population-based cancer registry
Qiong Chen, Chen Cheng, Yin Liu, Lanwei Guo, Huifang Xu, Hong Wang, Xiaoyang Wang, Luyao Zhang, Shaokai Zhang, Binbin Han
Annals of Translational Medicine
 2022;
10
(18)
:1012
Bioinformatics analysis of genomic and immune infiltration patterns in autism spectrum disorder
Ru-Qiong Wei, Wen-Liang Guo, Yin-Teng Wu, Raquel Alarcòn Rodrìguez, Marìa del Mar Requena Mullor, Yu-Chang Gui, Jian-Wen Xu
Annals of Translational Medicine
 2022;
10
(18)
:1013
Molecular mechanism of CD163+ tumor-associated macrophage (TAM)-derived exosome-induced cisplatin resistance in ovarian cancer ascites
Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Jinhong Chen, Xiaoqing Guo
Annals of Translational Medicine
 2022;
10
(18)
:1014
Analysis of the factors influencing teamwork among oncology nurses based on multigroup structural equation model
Xiaoxia Xu, Sansan Jia, Shaokai Zhang, Xuan Mai, Zhenxue Mao, Binbin Han
Annals of Translational Medicine
 2022;
10
(18)
:1015
Comparing the efficacy and safety of tenofovir and adefovir or combined drug treatment for the treatment of chronic hepatitis B infection: a systematic review and meta-analysis
Zeyu Bi, Ling Wang, Huixin Hou, Miao Lu, Wei Wang, Zishuo Li, Chengjiang Liu
Annals of Translational Medicine
 2022;
10
(18)
:1016
Exploring biomarkers and transcriptional factors in type 2 diabetes by comprehensive bioinformatics analysis on RNA-Seq and scRNA-Seq data
Yalan Huang, Linkun Cai, Xiu Liu, Yongjun Wu, Qin Xiang, Rong Yu
Annals of Translational Medicine
 2022;
10
(18)
:1017
Percutaneous endovenous intervention versus anticoagulation in the treatment of lower extremity deep vein thrombosis: a systematic review and meta-analysis
Guofu Hu, Jian Wang
Annals of Translational Medicine
 2022;
10
(18)
:1018
Comparing the efficacy and safety of atomization of traditional Chinese medicine Kai Hou Jian and budesonide suspension in adult acute laryngitis: a randomized control trial
Wei Feng, Hui Chen, Ye Lu, Rui Liu, Meng Yan Yuan, Jie An, Man Li, Lee Suan Chua, Joana Alcoba Kait, Li Xin
Annals of Translational Medicine
 2022;
10
(18)
:1019
A finite element analysis of the supportive effect of a new type of rotary support plate on lateral tibial plateau fractures
Shijie Gao, Quan Cheng Yao, Lindan Geng, Jian Lu, Ming Li, Kai An, Guowei Ren, Federico Canavese, Seok Jung Kim, Chukwuweike Gwam, Pengcheng Wang, Dong Ren
Annals of Translational Medicine
 2022;
10
(18)
:1020
The cuproptosis-related gene signature serves as a potential prognostic predictor for ovarian cancer using bioinformatics analysis
Xin Sun, Panling Xu, Fengli Zhang, Ting Sun, Haili Jiang, Xinyuan Lu, Mei Zhang, Ping Li
Annals of Translational Medicine
 2022;
10
(18)
:1021

Review Article

The role of non-coding RNAs in myocarditis: a narrative review
Wenhu Liu, Jing Hu, Shuai Lu, Zhaohui Wang
Annals of Translational Medicine
 2022;
10
(18)
:1022
Research advances in airway remodeling in asthma: a narrative review
Yanmei Huang, Chen Qiu
Annals of Translational Medicine
 2022;
10
(18)
:1023
Adeno-associated virus vector-mediated gene therapy for the treatment of ovarian cancer: a literature review
Jiaojiao Zhu, Tiansheng Qin, Linzhen Wei, Fan Chen, Yaoyao Ding, Qianqian Zhang, Yamei Dang
Annals of Translational Medicine
 2022;
10
(18)
:1024

Case Report

Diagnosis and treatment of adult Langerhans cell histiocytosis in the rib: a case report and literature review
Xin Li, Xufeng Liu, Daqiang Sun
Annals of Translational Medicine
 2022;
10
(18)
:1025
Combination of Type I and II tyrosine kinase inhibitors—avapritinib and sunitinib—in refractory gastrointestinal stromal tumor after failure to multi-line therapy: a case report
Xiaodan Guo, Shaoqing Huang, Yihang Shi, Zhaoming Guan, Sile Chen, Yun Feng, Yanzhe Xia, Xinhua Zhang
Annals of Translational Medicine
 2022;
10
(18)
:1026
Sheng-Xue-Xiao-Ban Capsule-induced ischemic colitis and pulmonary embolism in an idiopathic thrombocytopenic purpura patient: a rare case report
Sisi Zhou, Quan Shi, Yanfeng Zheng, Yihan Zhuang, Yiting Lin, Zeyu Huang, Jing Yu
Annals of Translational Medicine
 2022;
10
(18)
:1027
Immunochemotherapy includes pembrolizumab for stage IIIB lung squamous cell carcinoma: a case report
Shuliang Zhang, Yizhou Huang, Maohui Chen, Guanglei Huang, Bin Zheng, Chun Chen
Annals of Translational Medicine
 2022;
10
(18)
:1028
Successful re-challenge of dabrafenib-trametinib combination therapy in advanced BRAFV600E-mutant non-small cell lung cancer after previous cytotoxic chemotherapy, targeted therapy, and immunotherapy: a case report
Yaran Xue, Yaqian Ren, Bing Yan, Zhaona Li, Chun Huang
Annals of Translational Medicine
 2022;
10
(18)
:1029

iMDT Corner

Anlotinib combined with chemotherapy and immunotherapy for advanced pulmonary sarcomatoid cancer: a case report and literature review
Mei-Na Piao, Xiao-Ting Ma, Pierre Tankere, Chong-Kin Liam, Jin-Li Li, Jian-Ping Wang
Annals of Translational Medicine
 2022;
10
(18)
:1030

Editorial Commentary

Sacituzumab govitecan and other antibody-drug conjugates targeting trophoblast cell-surface antigen 2 (Trop-2) in breast cancer
Ashley Matusz-Fisher, Antoinette R. Tan
Annals of Translational Medicine
 2022;
10
(18)
:1031
Redox regulation of hybrid metabolic state in breast cancer metastasis
Kuldeep S. Attri, Jun Hyoung Park, Benny Abraham Kaipparettu
Annals of Translational Medicine
 2022;
10
(18)
:1032

Insights From the Reporting Guidelines1

Prof. Diana R. Elbourne: CONSORT for Cluster Randomized Trials and CONSORT for Noninferiority and Equivalence Trials
Kathy J. Du, Grace S. Li, Kaiping Zhang, Yao Lin, Fanghui Yang, Diana R. Elbourne
Annals of Translational Medicine
 2022;
10
(18)
:1033

Review Article on Challenges in Clinical Trials2

Novel clinical trial design and analytic methods to tackle challenges in therapeutic development in rare diseases
Yimei Li, Rima Izem
Annals of Translational Medicine
 2022;
10
(18)
:1034
Challenges and opportunities in biomarker-driven trials: adaptive randomization
Yeonhee Park
Annals of Translational Medicine
 2022;
10
(18)
:1035
Current usage and challenges of master protocols—based on survey results by ASA BIOP oncology methodology working group master protocol sub-team
Xiaoyun Li, Chengxing Lu, Kristine Broglio, Paul Bycott, Jie Chen, Qi Jiang, Jianchang Lin, Jingjing Ye, Jun Yin
Annals of Translational Medicine
 2022;
10
(18)
:1036
Sources of bias for single-arm phase II cancer clinical trials
Sin-Ho Jung
Annals of Translational Medicine
 2022;
10
(18)
:1037
Challenges, opportunities, and innovative statistical designs for precision oncology trials
Jun Yin, Shihao Shen, Qian Shi
Annals of Translational Medicine
 2022;
10
(18)
:1038

Letter to the Editor on Challenges in Clinical Trials2

The promises and challenges of pragmatism: lesson from of a recent clinical trial
Xiaoxi Yao, Peter A. Noseworthy
Annals of Translational Medicine
 2022;
10
(18)
:1039

Disclosure:

1. The series “Insights from the Reporting Guidelines” was commissioned by the editorial office, Annals of Translational Medicine without any funding or sponsorship.

2. The series “Challenges in Clinical Trials” was commissioned by the editorial office, Annals of Translational Medicine without any funding or sponsorship. Yanhong Deng, Qian Shi and Jun (Vivien) Yin served as the unpaid Guest Editors for the series.

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article


Review Article



Editorial Commentary





Insights From the Reporting Guidelines