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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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Endorsement
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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma
Tilo Winkler
Annals of Translational Medicine
 2022;
10
(22)
:1188
Airway remodeling in asthma
Carolyn Damilola Ekpruke, Patricia Silveyra
Annals of Translational Medicine
 2022;
10
(22)
:1189
Epigenetics of asthma—the field continues to evolve
Deepa Rastogi
Annals of Translational Medicine
 2022;
10
(22)
:1190

Original Article

Particle beam radiation therapy for head and neck rhabdomyosarcoma in adults
Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxing Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Annals of Translational Medicine
 2022;
10
(22)
:1191
A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers
Wenna Zhang, Lin Kong, Jiade J. Lu
Annals of Translational Medicine
 2022;
10
(22)
:1192
Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study
Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu
Annals of Translational Medicine
 2022;
10
(22)
:1193
Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma
Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu
Annals of Translational Medicine
 2022;
10
(22)
:1194
Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas
Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu
Annals of Translational Medicine
 2022;
10
(22)
:1195
Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study
Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu
Annals of Translational Medicine
 2022;
10
(22)
:1196
Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers
Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong
Annals of Translational Medicine
 2022;
10
(22)
:1197
The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx
Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Annals of Translational Medicine
 2022;
10
(22)
:1198
Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy
Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong
Annals of Translational Medicine
 2022;
10
(22)
:1199
Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies
Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Annals of Translational Medicine
 2022;
10
(22)
:1200
MiR-148a-3p attenuates apoptosis and inflammation by targeting CNTN4 in atherosclerosis
Kai Wang, Xi-Tong Huang, Yan-Ping Miao, Xiao-Long Bai, Feng Jin
Annals of Translational Medicine
 2022;
10
(22)
:1201
NLRP3 mediates trophoblastic inflammasome activation and protects against Listeria monocytogenes infection during pregnancy
Yu Gao, Min Zhou, Wen Zhang, Jinxing Jiang, Zhibin Ouyang, Yuanfang Zhu, Ning Li
Annals of Translational Medicine
 2022;
10
(22)
:1202
FGF10 mediates protective anti-oxidative effects in particulate matter-induced lung injury through Nrf2 and NF-κB signaling
Qiang Wang, Qiangqiang Shi, Li Liu, Yao Qian, Nian Dong
Annals of Translational Medicine
 2022;
10
(22)
:1203
Identification of key genes associated with cancer stem cell characteristics in Wilms’ tumor based on bioinformatics analysis
Cheng Su, Jie Zheng, Siyu Chen, Jinwei Tuo, Jinxia Su, Xiuyi Ou, Shaohua Chen, Congjun Wang
Annals of Translational Medicine
 2022;
10
(22)
:1204
PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis
Ni Kong, Qin Xu, Wei Cui, Xiaoying Feng, Huijie Gao
Annals of Translational Medicine
 2022;
10
(22)
:1205
Long-term clinical outcomes of Chinese diabetic patients after coronary revascularization with drug-eluting stents: a retrospective comparative cohort study
Yanping Li, Jixuan Liu, Yupeng Du, Duan Lei, Hongbin Liu
Annals of Translational Medicine
 2022;
10
(22)
:1206
Water search and rescue (SAR) for ship accidents in China: analysis of 12 years’ data
Jie Huang, Ning Han, Bi-Qing Jiang, Yan Cao, Xiao-Tong Han
Annals of Translational Medicine
 2022;
10
(22)
:1207
Does a longer second stage of labor worsen umbilical artery blood gas parameters in newborns?—a retrospective cohort study of 2,140 cases
Chuo Li, Tiantian He, Jin Zhou, Zhangmin Tan, Peizhen Zhang, Yuzhu Yin
Annals of Translational Medicine
 2022;
10
(22)
:1208
Relationship between hysterectomy and stroke in National Health and Nutrition Examination Survey (NHANES) 2007–2018: a cross-sectional study
Kun Cheng, Xiaojun Liu
Annals of Translational Medicine
 2022;
10
(22)
:1209
Flurbiprofen axetil alleviates the effect of formalin-induced inflammatory pain on the cognitive function of rats with mild cognitive impairment through the AMPKα/NF-κB signaling pathway
Linshen Huang, Xiaohong Zheng, Yanping Zhang, Yuerong Lin, Lanying Lin, Youguang Gao, Xianzhong Lin
Annals of Translational Medicine
 2022;
10
(22)
:1210
Clinical retrospective study on the efficacy and safety of endoscopic ear surgery for adhesive otitis media
Ya-Nan Guo, Minfei Qian, Jiping Li, Ji Xu, Hao Chen, Hua Zhang
Annals of Translational Medicine
 2022;
10
(22)
:1211
Comparison of risk of peritoneal dialysis-associated peritonitis between roxadustat and recombinant human erythropoietin in peritoneal dialysis patients: a retrospective comparative cohort study
Wei Zhang, Yanhong Tan, Jun Ai, Fuzhang Luo, Xiaoyan Su, Qimeng Wu, Lijuan Su, Jianyi Pan, Qingkun Zheng, Bin Li, Jiayi Chen, Qimei Luo, Jinzhong Chen, Xianrui Dou
Annals of Translational Medicine
 2022;
10
(22)
:1212
Spermine synthase (SMS) serves as a prognostic biomarker in head and neck squamous cell carcinoma: a bioinformatics analysis
Xiaoyu Pan, Lijun Xue, Yihan Sun
Annals of Translational Medicine
 2022;
10
(22)
:1213
MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
Du-Jiang Yang, Xiao-Dong Wang, Xiao-Ying Fu, Hui-Min Lu, Zong-Guang Zhou, Yong Liu
Annals of Translational Medicine
 2022;
10
(22)
:1214
Single-cell transcriptomic, transcriptomic, and metabolomic characterization of human atherosclerosis
Xiaoyang Liu, Li Li, Yiru Yin, Likui Zhang, Wenhao Wang
Annals of Translational Medicine
 2022;
10
(22)
:1215
Isorhamnetin inhibits progression of ovarian cancer by targeting ESR1
Manman Wang, Zhengtan Xu, Qi Cai, Yanmei Deng, Weiqiao Shi, Hongyu Zhou, Dajiang Wang, Jian Li
Annals of Translational Medicine
 2022;
10
(22)
:1216
Efficacy and safety of auto-cross-linked hyaluronic gel to prevent intrauterine adhesion after hysteroscopic electrosurgical resection: a multi-center randomized controlled trial
Hengxi Chen, Wei Xiong, Yuhua Zeng, Haihong Du, Lin Ye, Liang Chen, Jia Chen, Yana Liu, Meiqin Gong, Xue Dong, Jie Liu, Xin Tan
Annals of Translational Medicine
 2022;
10
(22)
:1217
BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson’s disease
Zhong-Ming Ying, Qian-Kun Lv, Xiao-Yu Yao, An-Qi Dong, Ya-Ping Yang, Yu-Lan Cao, Fen Wang, Ai-Ping Gong, Chun-Feng Liu
Annals of Translational Medicine
 2022;
10
(22)
:1218
Sinuvertebral nerve block treats discogenic low back pain: a retrospective cohort study
Zezheng Liu, Runxun Ma, Chaohui Fan, Junjie Chen, Rusen Zhang, Zhiyang Zheng, Yejie Xu, Zexian Liu, Qinghao Zhao, Qingchu Li
Annals of Translational Medicine
 2022;
10
(22)
:1219
18F-FDG PET/CT and MR imaging features of liver metastases in gastrointestinal stromal tumors: a cross-sectional analysis
Qinghu Lyu, Duanyu Lin, Mingdeng Tang, Daojia Liu, Jieping Zhang, Yuntao Wang, Vishal G. Shelat, Driss Raissi, Vikas Ostwal, Xingfa Chen, Shengxu Li
Annals of Translational Medicine
 2022;
10
(22)
:1220
Development and validation of the prediction models for preeclampsia: a retrospective, single-center, case-control study
Xuhong Chen, Li Yuan, Zhen Ji, Xiyun Bian, Shaofang Hua
Annals of Translational Medicine
 2022;
10
(22)
:1221
Patterns of care and prognostic evaluation for stage I–III upper esophageal squamous cell carcinoma: a population-based study
Dongbo Chen, Xiaozhu Zha, Dongmei Ye, Mei Kang, Liyang Zhu, Mingwei Yang, Yu Chen, Kechao Zhu, Wanli Xia, Zhi Wang, Yichun Wang
Annals of Translational Medicine
 2022;
10
(22)
:1222
Effects of short-term waterfall forest aerosol air exposure on rat lung proteomics
Zixin Zhu, Xueke Zhao, Lili Zhu, Yan Xiong, Shuo Cong, Mingyu Zhou, Manman Zhang, Mingliang Cheng, Xinhua Luo
Annals of Translational Medicine
 2022;
10
(22)
:1223
Effect of Roxadustat versus erythropoietin (EPO) for treating anemia in patients with diabetic kidney disease: a retrospective cohort study
Lei Zhang, Yulu Liu, Ying Huang, Yuee Zhao, Cong Wei, Kexin Yang, Xiaohui Li, Shumin Zhang, Wenpeng Wang, Yu Liu, Fuyou Liu, Lin Sun, Li Xiao
Annals of Translational Medicine
 2022;
10
(22)
:1224
Oxygen pulse variation in symptomatic patients with suspected coronary artery disease: a diagnostic analysis
Shangwei Huang, Lijie Wang, Jimin Li, Lan Ma, Xiaoyan He, Qi Zhang, Ying Li
Annals of Translational Medicine
 2022;
10
(22)
:1225
Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis
Yuan Zhou, Zhongbo Huang, Chen Wang, Jinping Su, Ping Jiang, Lili Li, Jinglin Qin, Zhi Xie
Annals of Translational Medicine
 2022;
10
(22)
:1226
Hypoxia-inducible factor 1α enhances RANKL-induced osteoclast differentiation by upregulating the MAPK pathway
Dong Wang, Lin Liu, Zechao Qu, Bo Zhang, Xiangcheng Gao, Wangli Huang, Mingzhe Feng, Yining Gong, Lingbo Kong, Yanjun Wang, Liang Yan
Annals of Translational Medicine
 2022;
10
(22)
:1227
Efficacy and safety of pyrotinib and radiotherapy vs. pyrotinib-based therapy in patients with HER2+ breast cancer with brain metastasis: a retrospective cohort study
Jiaxin Chen, Huiqiang Zhang, Jinmei Zhou, Zisheng Wu, Xuexue Wu, Shaohua Zhang, Zefei Jiang, Tao Wang
Annals of Translational Medicine
 2022;
10
(22)
:1228
Using arterial phase hyperenhancement on CT instead of gadoxetic acid arterial phase enhancement may improve the diagnostic performance for hepatocellular carcinoma
Hehan Tang, Feifei Gao, Yi Wei, Liping Deng, Qian Li, Yuan Yuan, Tong Zhang, Guoyong Chen, Shan Yao, Xiaocheng Wei, Lisha Nie, Bin Song, Zhenlin Li
Annals of Translational Medicine
 2022;
10
(22)
:1229
Microbiome and metabolome analysis to clarify the interaction between the urine microbiota and serum metabolites in Chinese patients with immunoglobulin A nephropathy
Shishi Li, Chiyu Ma, Yan Yang, Wanxia Cai, Weier Dai, Xinzhou Zhang, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Annals of Translational Medicine
 2022;
10
(22)
:1230
Comparison between free posterior tibial flap and free radial forearm flap for head and neck reconstruction: an anatomical study and a retrospective comparative cohort study
Qi Zhong, Jugao Fang, Zhigang Huang, Yang Zhang, Shizhi He, Yonggang Jin, Hongzhi Ma, Lizhen Hou, Wei Guo, Yuan Wang, Yurong He, Xiaoyan Wang
Annals of Translational Medicine
 2022;
10
(22)
:1231
Comprehensive analysis of cuproptosis-related lncRNAs in the prognosis and therapy response of patients with bladder cancer
Ding Li, Xuan Wu, Xinxin Fan, Cheng Cheng, Dongbei Li, Wenzhou Zhang
Annals of Translational Medicine
 2022;
10
(22)
:1232
The value of the Advanced Lung Cancer Inflammation Index (ALI) in assessing the prognosis of patients with hepatocellular carcinoma treated with camrelizumab: a retrospective cohort study
Qian Li, Fei Ma, Diamantis I. Tsilimigras, Fredrik Åberg, Ju Feng Wang
Annals of Translational Medicine
 2022;
10
(22)
:1233
Effects of β-blockers therapy on the 28-day and 3-year survival rates of end-stage renal disease patients with cardiovascular disease: a retrospective cohort study
Yong Wang, Zheqian Wu, Shijie Lu, Lili Yin, Yuandong Chen, Canyi Qiu, Pauline Yeung Ng, Koray Durak, Cristian Deana, Fei Ding, Zhiyan Zhang, Lihua Dai
Annals of Translational Medicine
 2022;
10
(22)
:1234
Clinical significance and immune landscape of cuproptosis-related lncRNAs in kidney renal clear cell carcinoma: a bioinformatical analysis
Ding Li, Xuan Wu, Wenping Song, Cheng Cheng, Lidan Hao, Wenzhou Zhang
Annals of Translational Medicine
 2022;
10
(22)
:1235
Chaetoglobosin E inhibits tumor growth and promotes the anti-tumor efficacy of cytotoxic drugs in esophageal squamous cell carcinoma by targeting PLK1
Jin-Hua Chen, Qing-Feng Guo, Qiu-Ge Liu, Bao-Xia He, Wen-Ping Song, Zhen-Hua Yin, Dong-Bei Li, Lin Chen, Wen-Zhou Zhang
Annals of Translational Medicine
 2022;
10
(22)
:1236
Newly found variations of the right posterior portal vein identified radiologically in 1,003 Chinese patients: a cross-sectional study
Jin-Yu Li, Wei-Dong Dai, Ji-Xiong Hu, Jiang-Sheng Huang, Xian-Ling Liu, Man-Jun Xiao, En-Hua Xiao, Ya-Jun Li, Xi-Long Mei, Kai Deng, Jing-Cheng Shi
Annals of Translational Medicine
 2022;
10
(22)
:1237
Targeted activation of ERK1/2 reduces ischemia and reperfusion injury in hyperglycemic myocardium by improving mitochondrial function
Fei Yu, Fen Liu, Jun-Yi Luo, Qian Zhao, Hong-Li Wang, Bin-Bin Fang, Xiao-Mei Li, Yi-Ning Yang
Annals of Translational Medicine
 2022;
10
(22)
:1238
The silencing of lnc-NONHSAT071210 suppresses the proliferation, fibrosis, migration, and invasion of TGFβ1-treated lung epithelial cells
Yuan Liu, Fuai Lu, Xiaofen Li, Youguo Yang, Jianqing Yang
Annals of Translational Medicine
 2022;
10
(22)
:1239
Glycolysis-related gene dihydrolipoamide acetyltransferase promotes poor prognosis in hepatocellular carcinoma through the Wnt/β-catenin and PI3K/Akt signaling pathways
Yuan Zhou, Haijuan Gu, Bingfeng Shao, Suqing Zhang, Harpreet Pall, Renata D’Alpino Peixoto, Shaffer R. S. Mok, Guodong Zhu
Annals of Translational Medicine
 2022;
10
(22)
:1240
Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α
Hao Wu, Cong Lu, Xing Li, Xianming Xu, Sufang Wu
Annals of Translational Medicine
 2022;
10
(22)
:1241
Corin is regulated by circ-0012397/miR-200a-3p and inhibits the oxygen-glucose deprivation-induced apoptosis of SHSY5Y neuroblastoma cells
Rui Yin, Caixia Qiu, Qikai Shen, Zhong Wang
Annals of Translational Medicine
 2022;
10
(22)
:1242
MiR-4291 stabilized the vulnerable atherosclerotic plaques by degrading the MAPK1/ERK2 in ApoE-/- mice
Yaqiong Jin, Jingchao Lu, Fan Liu, Xiuchun Yang, Fei Chen, Jie Zhang
Annals of Translational Medicine
 2022;
10
(22)
:1243
Efficacy and safety of different doses of remimazolam tosylate for colonoscopy: single-center, prospective, randomized, double-blind, parallel trial
Xiaoyan Zheng, Junhui Ji, Hao Cheng, Ke Peng, Linlin Liu, Fuhai Ji
Annals of Translational Medicine
 2022;
10
(22)
:1244
TGR5 overexpression mediated by the inhibition of transcription factor SOX9 protects against hypoxia-/reoxygenation-induced injury in hippocampal neurons by activating Nrf2/HO-1 signaling
Hong Jia, Yaoqi Chen, Yalin Liu
Annals of Translational Medicine
 2022;
10
(22)
:1245
Oncogenic alterations reveal key strategies for precision oncology in melanoma treatment
Wei Sun, Fang Zhao, Tu Hu, Zhiqiang Wu, Yu Xu, Yan Dong, Biqiang Zheng, Chunmeng Wang, Wangjun Yan, Xiaoli Zhu, Jian Wu, Michael J. McKay, Imanol Arozarena, Llucia Alos, Cristina Teixido, Yong Chen
Annals of Translational Medicine
 2022;
10
(22)
:1246
Modified pedicled temporoparietal fascial flap combined revascularization in adult moyamoya angiopathy
Wenchao Zhang, Xiaoguang Tong, Xuan Wang, Yang Sun, Tang Li
Annals of Translational Medicine
 2022;
10
(22)
:1247
Identification of the molecular mechanism and candidate markers for diabetic nephropathy
Chun Chen, Liping Liu, Jia Luo
Annals of Translational Medicine
 2022;
10
(22)
:1248
Multi-omics profiling identifies C1QA/B+ macrophages with multiple immune checkpoints associated with esophageal squamous cell carcinoma (ESCC) liver metastasis
Fei Zheng, Wei Zhang, Baihua Yang, Mingqiu Chen
Annals of Translational Medicine
 2022;
10
(22)
:1249

Review Article

Tissue factor as a new target for tumor therapy—killing two birds with one stone: a narrative review
Xiaoying Li, Dan Cao, Xiufeng Zheng, Gang Wang, Ming Liu
Annals of Translational Medicine
 2022;
10
(22)
:1250
A narrative review on the development of the ethical review mode of multicenter clinical trials in China
Jing Ding, Yashu Yin, Keke Fang, Wenzhou Zhang, Suxia Luo
Annals of Translational Medicine
 2022;
10
(22)
:1251

Special Report

Infection control management strategy for operating room during COVID-19 pandemic
Yihua Dai, Ru Zhang, Yanhua Jiang, Huidan Jin, Jingya Zhao, Anshun Guo, Xian Chen, Dongyi Fan, Lukun Yang
Annals of Translational Medicine
 2022;
10
(22)
:1252

Case Report

Creating a re-expanded prefabricated island flap constructed with an anastomosed vascular pedicle for burned ear reconstruction: a case report
Yang Chen, Wanfu Zhang, Fei Han, Xiaolong Hu, Lin Tong, Yunwei Wang, Shaohui Li, Peng Cao, Liwei Dong, Hao Guan
Annals of Translational Medicine
 2022;
10
(22)
:1253
The efficacy of oxaliplatin, surufatinib, and camrelizumab on neuroendocrine carcinoma: a case report and literature review
Xianhua Wang, Shaobo Hu, Fei Su, Jie Lin, Jianghui Duan, Haidong Tan, Huangying Tan
Annals of Translational Medicine
 2022;
10
(22)
:1254
Hereditary spherocytosis complicated by intrahepatic cholestasis: two case reports
Ning Han, Wei Huang, Juan Wang, Lang Bai, Libo Yan, Hong Tang
Annals of Translational Medicine
 2022;
10
(22)
:1255

iMDT Corner

Diabetic ketoacidosis induced by nivolumab in invasive mucinous adenocarcinoma of the lung: a case report and review of the literature
Juan Yan, Zheng-Zheng Xie, Teresa Moran, Cesare Gridelli, Mao-Dong Zheng, Su-Juan Dai
Annals of Translational Medicine
 2022;
10
(22)
:1256

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article


Review Article


Case Report



Editorial Commentary