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Challenges in Clinical Trials

This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

While China’s academic field is flourishing, ATM is blooming and become a choice of publication venue for more and more recognized affiliations. For ATM, it is precisely a type of recognition—by the country's top academic institutions and the most important think tanks in the country in the form of publication venue choice—that makes ATM stay in the scientific research fronts and able to further realize its mission of translating between bench and bedside. ATM's educational value is mostly based on the objective opinions of a group of field experts within the scientific community.

Reviewer of the Month (2022)

In 2022, ATM reviewers continue to make outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work.

Interviews with Outstanding Authors (2022)

In 2022, many ATM authors make outstanding contributions to our journal. Their articles published with us have received very well feedback in the field and stimulate a lot of discussions and new insights among the peers.

Hereby, we would like to highlight some of our outstanding authors who have been making immense efforts in their research fields, with a brief interview of their unique perspective and insightful view as authors.

The Modern Plastic and Reconstructive Surgeon – Collaborator, Innovator, Leader (Ongoing)

This special series on “The Modern Plastic and Reconstructive Surgeon – Collaborator, Innovator, Leader” is edited by Dr. Johnny Ionut Efanov, from the Division of Plastic and Reconstructive Surgery, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.

Foot and Ankle Surgery (Ongoing)

This special series on “Foot and Ankle Surgery” is edited by Dr. Albert T. Anastasio from Department of Orthopaedic Surgery, Duke University Hospital, and aims to provide an updated overview of the most recent acquisitions and future perspectives.

Breast Reconstruction (Ongoing)

This special series on “Breast Reconstruction” is edited by Dr. Oscar J. Manrique from the University of Rochester Medical Center, and aims to provide an updated overview of the most recent acquisitions and future perspectives.

New Impact Factor for Annals of Translational Medicine: 3.616

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2021 citation year: 3.616.

Novel Tools and Therapies for Ocular Regeneration

This special series is very timely since there has been a recent increase in the momentum of translational research in ocular regeneration. This increase stems partially from the success of ocular gene therapy. This special eye series includes review and original articles of novel tools and therapies being developed for ocular regeneration. The goal of this eye series is to provide some overview of the latest research being done in the area of ocular regeneration in order to highlight the broad potential in this field.

Endovascular Interventions in Trauma

Trauma is a leading cause of death and disability and predominately effects young patients. Trauma teams include many health care professionals from many subspecialties. Endovascular specialists such as interventional radiologists and vascular surgeons play an ever growing role in this team and in the care of these patients. In this focused series on endovascular interventions in trauma, articles will discuss the endovascular treatment of traumatic aortic injury, splenic, hepatic, renal pelvic and extremity trauma. Additionally, we include an article on the emerging technology of resuscitative endovascular balloon occlusion of the aorta (REBOA).

Highlights in Anesthesia and Critical Care Medicine (Ongoing)

Guest Editors: Tobias Eckle and Benjamin Scott (Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA)

Lung Cancer Management—The Next Decade (Ongoing)

This special series on “Lung Cancer Management—The Next Decade” is edited by Dr. Calvin S. H. Ng. Lung cancer remains a disease associated with high morbidity and mortality. It is only in the past decade or so that newer forms of therapies have gradually become available. Targeted and immunotherapies, specialized radiation ion therapies; and operative approaches that are more tailored to the individual with improved precision and lower surgical trauma have been in rapid development.

ATM Annual Report 2021

Greetings from the editorial office of ATM. We wish you a happy new year in 2022. In 2021, ATM has made great progress under the joint-efforts of experts worldwide.

- More than 1800 papers have been published in ATM in 2021.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,860,685 times in 2021.
- The number of total citations by SCI journals has significantly increased to 36,500 till December 2021.
- The pageviews of ATM journal website is increasing significantly, with a total of 2,869,820 hits in 2021.

Carotid Artery Stenosis and Stroke-Prevention and Treatment Part II

Prevention and treatment of ischemic carotid-related strokes is a research priority. All controversial issues should be addressed to optimize patient outcomes. The current series are the second part of two series on the prevention and treatment of carotid artery stenosis and carotid-related strokes. Hopefully, these two series will help to answer many of the current questions and to resolve some of the controversial issues on the topic.

Annals of Translational Medicine (ATM) is now a member of Committee on Publication Ethics (COPE)

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

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Vol 10, No 22 (November, 2022)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma

Tilo Winkler

Annals of Translational Medicine

2022;

(22)

:1188

| https://dx.doi.org/10.21037/atm-22-5095

(November 2022)

PDF Full Text (125) COI Form Open Access

Airway remodeling in asthma

Carolyn Damilola Ekpruke, Patricia Silveyra

Annals of Translational Medicine

2022;

(22)

:1189

| https://dx.doi.org/10.21037/atm-22-5059

(November 2022)

PDF Full Text (100) COI Form Open Access

Epigenetics of asthma—the field continues to evolve

Deepa Rastogi

Annals of Translational Medicine

2022;

(22)

:1190

| https://dx.doi.org/10.21037/atm-22-5022

(November 2022)

PDF Full Text (71) COI Form Open Access

Original Article

Particle beam radiation therapy for head and neck rhabdomyosarcoma in adults

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxing Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Annals of Translational Medicine

2022;

(22)

:1191

| https://dx.doi.org/10.21037/atm-20-8238

(November 2022)

PDF Full Text (157) Reporting Checklist Data Sharing Statement COI Form Open Access

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

Annals of Translational Medicine

2022;

(22)

:1192

| https://dx.doi.org/10.21037/atm-20-7760

(November 2022)

PDF Full Text (103) COI Form Open Access

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Annals of Translational Medicine

2022;

(22)

:1193

| https://dx.doi.org/10.21037/atm-20-7750

(November 2022)

PDF Full Text (94) Reporting Checklist Data Sharing Statement COI Form Open Access

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

Annals of Translational Medicine

2022;

(22)

:1194

| https://dx.doi.org/10.21037/atm-20-7805

(November 2022)

PDF Full Text (83) Reporting Checklist Data Sharing Statement COI Form Open Access

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Annals of Translational Medicine

2022;

(22)

:1195

| https://dx.doi.org/10.21037/atm-20-7988

(November 2022)

PDF Full Text (55) Reporting Checklist Data Sharing Statement COI Form Open Access

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Annals of Translational Medicine

2022;

(22)

:1196

| https://dx.doi.org/10.21037/atm-20-5214

(November 2022)

PDF Full Text (52) Reporting Checklist Data Sharing Statement COI Form Open Access

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Annals of Translational Medicine

2022;

(22)

:1197

| https://dx.doi.org/10.21037/atm-20-5078

(November 2022)

PDF Full Text (52) Reporting Checklist Data Sharing Statement COI Form Open Access

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Annals of Translational Medicine

2022;

(22)

:1198

| https://dx.doi.org/10.21037/atm-20-1767

(November 2022)

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Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Annals of Translational Medicine

2022;

(22)

:1199

| https://dx.doi.org/10.21037/atm-20-1646

(November 2022)

PDF Full Text (58) COI Form Open Access

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Annals of Translational Medicine

2022;

(22)

:1200

| https://dx.doi.org/10.21037/atm-20-200

(November 2022)

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MiR-148a-3p attenuates apoptosis and inflammation by targeting CNTN4 in atherosclerosis

Kai Wang, Xi-Tong Huang, Yan-Ping Miao, Xiao-Long Bai, Feng Jin

Annals of Translational Medicine

2022;

(22)

:1201

| https://dx.doi.org/10.21037/atm-22-3768

(November 2022)

PDF Full Text (76) Reporting Checklist Data Sharing Statement COI Form Open Access

NLRP3 mediates trophoblastic inflammasome activation and protects against Listeria monocytogenes infection during pregnancy

Yu Gao, Min Zhou, Wen Zhang, Jinxing Jiang, Zhibin Ouyang, Yuanfang Zhu, Ning Li

Annals of Translational Medicine

2022;

(22)

:1202

| https://dx.doi.org/10.21037/atm-22-4120

(November 2022)

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FGF10 mediates protective anti-oxidative effects in particulate matter-induced lung injury through Nrf2 and NF-κB signaling

Qiang Wang, Qiangqiang Shi, Li Liu, Yao Qian, Nian Dong

Annals of Translational Medicine

2022;

(22)

:1203

| https://dx.doi.org/10.21037/atm-22-4389

(November 2022)

PDF Full Text (74) Reporting Checklist Data Sharing Statement COI Form Open Access

Identification of key genes associated with cancer stem cell characteristics in Wilms’ tumor based on bioinformatics analysis

Cheng Su, Jie Zheng, Siyu Chen, Jinwei Tuo, Jinxia Su, Xiuyi Ou, Shaohua Chen, Congjun Wang

Annals of Translational Medicine

2022;

(22)

:1204

| https://dx.doi.org/10.21037/atm-22-4477

(November 2022)

PDF Full Text (88) COI Form Open Access

PCSK9 inhibitor inclisiran for treating atherosclerosis via regulation of endothelial cell pyroptosis

Ni Kong, Qin Xu, Wei Cui, Xiaoying Feng, Huijie Gao

Annals of Translational Medicine

2022;

(22)

:1205

| https://dx.doi.org/10.21037/atm-22-4652

(November 2022)

PDF Full Text (94) Reporting Checklist Data Sharing Statement COI Form Open Access

Long-term clinical outcomes of Chinese diabetic patients after coronary revascularization with drug-eluting stents: a retrospective comparative cohort study

Yanping Li, Jixuan Liu, Yupeng Du, Duan Lei, Hongbin Liu

Annals of Translational Medicine

2022;

(22)

:1206

| https://dx.doi.org/10.21037/atm-22-4517

(November 2022)

PDF Full Text (53) Reporting Checklist Data Sharing Statement COI Form Open Access

Water search and rescue (SAR) for ship accidents in China: analysis of 12 years’ data

Jie Huang, Ning Han, Bi-Qing Jiang, Yan Cao, Xiao-Tong Han

Annals of Translational Medicine

2022;

(22)

:1207

| https://dx.doi.org/10.21037/atm-22-4530

(November 2022)

PDF Full Text (60) Reporting Checklist COI Form Open Access

Does a longer second stage of labor worsen umbilical artery blood gas parameters in newborns?—a retrospective cohort study of 2,140 cases

Chuo Li, Tiantian He, Jin Zhou, Zhangmin Tan, Peizhen Zhang, Yuzhu Yin

Annals of Translational Medicine

2022;

(22)

:1208

| https://dx.doi.org/10.21037/atm-22-4604

(November 2022)

PDF Full Text (51) Reporting Checklist Data Sharing Statement COI Form Open Access

Relationship between hysterectomy and stroke in National Health and Nutrition Examination Survey (NHANES) 2007–2018: a cross-sectional study

Kun Cheng, Xiaojun Liu

Annals of Translational Medicine

2022;

(22)

:1209

| https://dx.doi.org/10.21037/atm-22-4681

(November 2022)

PDF Full Text (57) Reporting Checklist COI Form Open Access

Flurbiprofen axetil alleviates the effect of formalin-induced inflammatory pain on the cognitive function of rats with mild cognitive impairment through the AMPKα/NF-κB signaling pathway

Linshen Huang, Xiaohong Zheng, Yanping Zhang, Yuerong Lin, Lanying Lin, Youguang Gao, Xianzhong Lin

Annals of Translational Medicine

2022;

(22)

:1210

| https://dx.doi.org/10.21037/atm-22-4997

(November 2022)

PDF Full Text (49) Reporting Checklist Data Sharing Statement COI Form Open Access

Clinical retrospective study on the efficacy and safety of endoscopic ear surgery for adhesive otitis media

Ya-Nan Guo, Minfei Qian, Jiping Li, Ji Xu, Hao Chen, Hua Zhang

Annals of Translational Medicine

2022;

(22)

:1211

| https://dx.doi.org/10.21037/atm-22-4831

(November 2022)

PDF Full Text (83) Reporting Checklist Data Sharing Statement COI Form Open Access

Comparison of risk of peritoneal dialysis-associated peritonitis between roxadustat and recombinant human erythropoietin in peritoneal dialysis patients: a retrospective comparative cohort study

Wei Zhang, Yanhong Tan, Jun Ai, Fuzhang Luo, Xiaoyan Su, Qimeng Wu, Lijuan Su, Jianyi Pan, Qingkun Zheng, Bin Li, Jiayi Chen, Qimei Luo, Jinzhong Chen, Xianrui Dou

Annals of Translational Medicine

2022;

(22)

:1212

| https://dx.doi.org/10.21037/atm-22-5050

(November 2022)

PDF Full Text (74) Reporting Checklist Data Sharing Statement COI Form Open Access

Spermine synthase (SMS) serves as a prognostic biomarker in head and neck squamous cell carcinoma: a bioinformatics analysis

Xiaoyu Pan, Lijun Xue, Yihan Sun

Annals of Translational Medicine

2022;

(22)

:1213

| https://dx.doi.org/10.21037/atm-22-5014

(November 2022)

PDF Full Text (57) Reporting Checklist COI Form Open Access

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis

Du-Jiang Yang, Xiao-Dong Wang, Xiao-Ying Fu, Hui-Min Lu, Zong-Guang Zhou, Yong Liu

Annals of Translational Medicine

2022;

(22)

:1214

| https://dx.doi.org/10.21037/atm-22-5134

(November 2022)

PDF Full Text (53) Reporting Checklist Data Sharing Statement COI Form Open Access

Single-cell transcriptomic, transcriptomic, and metabolomic characterization of human atherosclerosis

Xiaoyang Liu, Li Li, Yiru Yin, Likui Zhang, Wenhao Wang

Annals of Translational Medicine

2022;

(22)

:1215

| https://dx.doi.org/10.21037/atm-22-4852

(November 2022)

PDF Full Text (79) Reporting Checklist Data Sharing Statement COI Form Open Access

Isorhamnetin inhibits progression of ovarian cancer by targeting ESR1

Manman Wang, Zhengtan Xu, Qi Cai, Yanmei Deng, Weiqiao Shi, Hongyu Zhou, Dajiang Wang, Jian Li

Annals of Translational Medicine

2022;

(22)

:1216

| https://dx.doi.org/10.21037/atm-22-5064

(November 2022)

PDF Full Text (90) Reporting Checklist Data Sharing Statement COI Form Open Access

Efficacy and safety of auto-cross-linked hyaluronic gel to prevent intrauterine adhesion after hysteroscopic electrosurgical resection: a multi-center randomized controlled trial

Hengxi Chen, Wei Xiong, Yuhua Zeng, Haihong Du, Lin Ye, Liang Chen, Jia Chen, Yana Liu, Meiqin Gong, Xue Dong, Jie Liu, Xin Tan

Annals of Translational Medicine

2022;

(22)

:1217

| https://dx.doi.org/10.21037/atm-22-4988

(November 2022)

PDF Full Text (86) Reporting Checklist Trial Protocol Data Sharing Statement COI Form Open Access

BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson’s disease

Zhong-Ming Ying, Qian-Kun Lv, Xiao-Yu Yao, An-Qi Dong, Ya-Ping Yang, Yu-Lan Cao, Fen Wang, Ai-Ping Gong, Chun-Feng Liu

Annals of Translational Medicine

2022;

(22)

:1218

| https://dx.doi.org/10.21037/atm-22-5159

(November 2022)

PDF Full Text (71) Reporting Checklist Data Sharing Statement COI Form Open Access

Sinuvertebral nerve block treats discogenic low back pain: a retrospective cohort study

Zezheng Liu, Runxun Ma, Chaohui Fan, Junjie Chen, Rusen Zhang, Zhiyang Zheng, Yejie Xu, Zexian Liu, Qinghao Zhao, Qingchu Li

Annals of Translational Medicine

2022;

(22)

:1219

| https://dx.doi.org/10.21037/atm-22-5297

(November 2022)

PDF Full Text (71) Reporting Checklist Data Sharing Statement COI Form Open Access

¹⁸F-FDG PET/CT and MR imaging features of liver metastases in gastrointestinal stromal tumors: a cross-sectional analysis

Qinghu Lyu, Duanyu Lin, Mingdeng Tang, Daojia Liu, Jieping Zhang, Yuntao Wang, Vishal G. Shelat, Driss Raissi, Vikas Ostwal, Xingfa Chen, Shengxu Li

Annals of Translational Medicine

2022;

(22)

:1220

| https://dx.doi.org/10.21037/atm-22-5181

(November 2022)

PDF Full Text (92) Reporting Checklist Data Sharing Statement COI Form Open Access

Development and validation of the prediction models for preeclampsia: a retrospective, single-center, case-control study

Xuhong Chen, Li Yuan, Zhen Ji, Xiyun Bian, Shaofang Hua

Annals of Translational Medicine

2022;

(22)

:1221

| https://dx.doi.org/10.21037/atm-22-4192

(November 2022)

PDF Full Text (73) Reporting Checklist Data Sharing Statement COI Form Open Access

Patterns of care and prognostic evaluation for stage I–III upper esophageal squamous cell carcinoma: a population-based study

Dongbo Chen, Xiaozhu Zha, Dongmei Ye, Mei Kang, Liyang Zhu, Mingwei Yang, Yu Chen, Kechao Zhu, Wanli Xia, Zhi Wang, Yichun Wang

Annals of Translational Medicine

2022;

(22)

:1222

| https://dx.doi.org/10.21037/atm-22-4577

(November 2022)

PDF Full Text (60) Reporting Checklist COI Form Open Access

Effects of short-term waterfall forest aerosol air exposure on rat lung proteomics

Zixin Zhu, Xueke Zhao, Lili Zhu, Yan Xiong, Shuo Cong, Mingyu Zhou, Manman Zhang, Mingliang Cheng, Xinhua Luo

Annals of Translational Medicine

2022;

(22)

:1223

| https://dx.doi.org/10.21037/atm-22-4813

(November 2022)

PDF Full Text (66) Reporting Checklist Data Sharing Statement COI Form Open Access

Effect of Roxadustat versus erythropoietin (EPO) for treating anemia in patients with diabetic kidney disease: a retrospective cohort study

Lei Zhang, Yulu Liu, Ying Huang, Yuee Zhao, Cong Wei, Kexin Yang, Xiaohui Li, Shumin Zhang, Wenpeng Wang, Yu Liu, Fuyou Liu, Lin Sun, Li Xiao

Annals of Translational Medicine

2022;

(22)

:1224

| https://dx.doi.org/10.21037/atm-22-4344

(November 2022)

PDF Full Text (106) Reporting Checklist Data Sharing Statement COI Form Open Access

Oxygen pulse variation in symptomatic patients with suspected coronary artery disease: a diagnostic analysis

Shangwei Huang, Lijie Wang, Jimin Li, Lan Ma, Xiaoyan He, Qi Zhang, Ying Li

Annals of Translational Medicine

2022;

(22)

:1225

| https://dx.doi.org/10.21037/atm-22-5279

(November 2022)

PDF Full Text (57) Reporting Checklist Data Sharing Statement COI Form Open Access

Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis

Yuan Zhou, Zhongbo Huang, Chen Wang, Jinping Su, Ping Jiang, Lili Li, Jinglin Qin, Zhi Xie

Annals of Translational Medicine

2022;

(22)

:1226

| https://dx.doi.org/10.21037/atm-22-4634

(November 2022)

PDF Full Text (98) Reporting Checklist COI Form Open Access

Hypoxia-inducible factor 1α enhances RANKL-induced osteoclast differentiation by upregulating the MAPK pathway

Dong Wang, Lin Liu, Zechao Qu, Bo Zhang, Xiangcheng Gao, Wangli Huang, Mingzhe Feng, Yining Gong, Lingbo Kong, Yanjun Wang, Liang Yan

Annals of Translational Medicine

2022;

(22)

:1227

| https://dx.doi.org/10.21037/atm-22-4603

(November 2022)

PDF Full Text (79) Reporting Checklist Data Sharing Statement COI Form Open Access

Efficacy and safety of pyrotinib and radiotherapy vs. pyrotinib-based therapy in patients with HER2⁺ breast cancer with brain metastasis: a retrospective cohort study

Jiaxin Chen, Huiqiang Zhang, Jinmei Zhou, Zisheng Wu, Xuexue Wu, Shaohua Zhang, Zefei Jiang, Tao Wang

Annals of Translational Medicine

2022;

(22)

:1228

| https://dx.doi.org/10.21037/atm-22-5352

(November 2022)

PDF Full Text (71) Reporting Checklist Data Sharing Statement COI Form Open Access

Using arterial phase hyperenhancement on CT instead of gadoxetic acid arterial phase enhancement may improve the diagnostic performance for hepatocellular carcinoma

Hehan Tang, Feifei Gao, Yi Wei, Liping Deng, Qian Li, Yuan Yuan, Tong Zhang, Guoyong Chen, Shan Yao, Xiaocheng Wei, Lisha Nie, Bin Song, Zhenlin Li

Annals of Translational Medicine

2022;

(22)

:1229

| https://dx.doi.org/10.21037/atm-22-4968

(November 2022)

PDF Full Text (58) Reporting Checklist Data Sharing Statement COI Form Open Access

Microbiome and metabolome analysis to clarify the interaction between the urine microbiota and serum metabolites in Chinese patients with immunoglobulin A nephropathy

Shishi Li, Chiyu Ma, Yan Yang, Wanxia Cai, Weier Dai, Xinzhou Zhang, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai

Annals of Translational Medicine

2022;

(22)

:1230

| https://dx.doi.org/10.21037/atm-22-5334

(November 2022)

PDF Full Text (85) Reporting Checklist Data Sharing Statement COI Form Open Access

Comparison between free posterior tibial flap and free radial forearm flap for head and neck reconstruction: an anatomical study and a retrospective comparative cohort study

Qi Zhong, Jugao Fang, Zhigang Huang, Yang Zhang, Shizhi He, Yonggang Jin, Hongzhi Ma, Lizhen Hou, Wei Guo, Yuan Wang, Yurong He, Xiaoyan Wang

Annals of Translational Medicine

2022;

(22)

:1231

| https://dx.doi.org/10.21037/atm-22-5426

(November 2022)

PDF Full Text (63) Reporting Checklist Data Sharing Statement COI Form Open Access

Comprehensive analysis of cuproptosis-related lncRNAs in the prognosis and therapy response of patients with bladder cancer

Ding Li, Xuan Wu, Xinxin Fan, Cheng Cheng, Dongbei Li, Wenzhou Zhang

Annals of Translational Medicine

2022;

(22)

:1232

| https://dx.doi.org/10.21037/atm-22-5294

(November 2022)

PDF Full Text (77) Reporting Checklist COI Form Open Access

The value of the Advanced Lung Cancer Inflammation Index (ALI) in assessing the prognosis of patients with hepatocellular carcinoma treated with camrelizumab: a retrospective cohort study

Qian Li, Fei Ma, Diamantis I. Tsilimigras, Fredrik Åberg, Ju Feng Wang

Annals of Translational Medicine

2022;

(22)

:1233

| https://dx.doi.org/10.21037/atm-22-5099

(November 2022)

PDF Full Text (83) Reporting Checklist Data Sharing Statement COI Form Open Access

Effects of β-blockers therapy on the 28-day and 3-year survival rates of end-stage renal disease patients with cardiovascular disease: a retrospective cohort study

Yong Wang, Zheqian Wu, Shijie Lu, Lili Yin, Yuandong Chen, Canyi Qiu, Pauline Yeung Ng, Koray Durak, Cristian Deana, Fei Ding, Zhiyan Zhang, Lihua Dai

Annals of Translational Medicine

2022;

(22)

:1234

| https://dx.doi.org/10.21037/atm-22-5317

(November 2022)

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Clinical significance and immune landscape of cuproptosis-related lncRNAs in kidney renal clear cell carcinoma: a bioinformatical analysis

Ding Li, Xuan Wu, Wenping Song, Cheng Cheng, Lidan Hao, Wenzhou Zhang

Annals of Translational Medicine

2022;

(22)

:1235

| https://dx.doi.org/10.21037/atm-22-5204

(November 2022)

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Chaetoglobosin E inhibits tumor growth and promotes the anti-tumor efficacy of cytotoxic drugs in esophageal squamous cell carcinoma by targeting PLK1

Jin-Hua Chen, Qing-Feng Guo, Qiu-Ge Liu, Bao-Xia He, Wen-Ping Song, Zhen-Hua Yin, Dong-Bei Li, Lin Chen, Wen-Zhou Zhang

Annals of Translational Medicine

2022;

(22)

:1236

| https://dx.doi.org/10.21037/atm-22-5320

(November 2022)

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Newly found variations of the right posterior portal vein identified radiologically in 1,003 Chinese patients: a cross-sectional study

Jin-Yu Li, Wei-Dong Dai, Ji-Xiong Hu, Jiang-Sheng Huang, Xian-Ling Liu, Man-Jun Xiao, En-Hua Xiao, Ya-Jun Li, Xi-Long Mei, Kai Deng, Jing-Cheng Shi

Annals of Translational Medicine

2022;

(22)

:1237

| https://dx.doi.org/10.21037/atm-22-4837

(November 2022)

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Targeted activation of ERK1/2 reduces ischemia and reperfusion injury in hyperglycemic myocardium by improving mitochondrial function

Fei Yu, Fen Liu, Jun-Yi Luo, Qian Zhao, Hong-Li Wang, Bin-Bin Fang, Xiao-Mei Li, Yi-Ning Yang

Annals of Translational Medicine

2022;

(22)

:1238

| https://dx.doi.org/10.21037/atm-22-5149

(November 2022)

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The silencing of lnc-NONHSAT071210 suppresses the proliferation, fibrosis, migration, and invasion of TGFβ1-treated lung epithelial cells

Yuan Liu, Fuai Lu, Xiaofen Li, Youguo Yang, Jianqing Yang

Annals of Translational Medicine

2022;

(22)

:1239

| https://dx.doi.org/10.21037/atm-22-5223

(November 2022)

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Glycolysis-related gene dihydrolipoamide acetyltransferase promotes poor prognosis in hepatocellular carcinoma through the Wnt/β-catenin and PI3K/Akt signaling pathways

Yuan Zhou, Haijuan Gu, Bingfeng Shao, Suqing Zhang, Harpreet Pall, Renata D’Alpino Peixoto, Shaffer R. S. Mok, Guodong Zhu

Annals of Translational Medicine

2022;

(22)

:1240

| https://dx.doi.org/10.21037/atm-22-5272

(November 2022)

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Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α

Hao Wu, Cong Lu, Xing Li, Xianming Xu, Sufang Wu

Annals of Translational Medicine

2022;

(22)

:1241

| https://dx.doi.org/10.21037/atm-22-5551

(November 2022)

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Corin is regulated by circ-0012397/miR-200a-3p and inhibits the oxygen-glucose deprivation-induced apoptosis of SHSY5Y neuroblastoma cells

Rui Yin, Caixia Qiu, Qikai Shen, Zhong Wang

Annals of Translational Medicine

2022;

(22)

:1242

| https://dx.doi.org/10.21037/atm-22-4943

(November 2022)

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MiR-4291 stabilized the vulnerable atherosclerotic plaques by degrading the MAPK1/ERK2 in ApoE^-/- mice

Yaqiong Jin, Jingchao Lu, Fan Liu, Xiuchun Yang, Fei Chen, Jie Zhang

Annals of Translational Medicine

2022;

(22)

:1243

| https://dx.doi.org/10.21037/atm-22-5241

(November 2022)

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Efficacy and safety of different doses of remimazolam tosylate for colonoscopy: single-center, prospective, randomized, double-blind, parallel trial

Xiaoyan Zheng, Junhui Ji, Hao Cheng, Ke Peng, Linlin Liu, Fuhai Ji

Annals of Translational Medicine

2022;

(22)

:1244

| https://dx.doi.org/10.21037/atm-22-5133

(November 2022)

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TGR5 overexpression mediated by the inhibition of transcription factor SOX9 protects against hypoxia-/reoxygenation-induced injury in hippocampal neurons by activating Nrf2/HO-1 signaling

Hong Jia, Yaoqi Chen, Yalin Liu

Annals of Translational Medicine

2022;

(22)

:1245

| https://dx.doi.org/10.21037/atm-22-5225

(November 2022)

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Oncogenic alterations reveal key strategies for precision oncology in melanoma treatment

Wei Sun, Fang Zhao, Tu Hu, Zhiqiang Wu, Yu Xu, Yan Dong, Biqiang Zheng, Chunmeng Wang, Wangjun Yan, Xiaoli Zhu, Jian Wu, Michael J. McKay, Imanol Arozarena, Llucia Alos, Cristina Teixido, Yong Chen

Annals of Translational Medicine

2022;

(22)

:1246

| https://dx.doi.org/10.21037/atm-22-5346

(November 2022)

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Modified pedicled temporoparietal fascial flap combined revascularization in adult moyamoya angiopathy

Wenchao Zhang, Xiaoguang Tong, Xuan Wang, Yang Sun, Tang Li

Annals of Translational Medicine

2022;

(22)

:1247

| https://dx.doi.org/10.21037/atm-22-5281

(November 2022)

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Identification of the molecular mechanism and candidate markers for diabetic nephropathy

Chun Chen, Liping Liu, Jia Luo

Annals of Translational Medicine

2022;

(22)

:1248

| https://dx.doi.org/10.21037/atm-22-5128

(November 2022)

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Multi-omics profiling identifies C1QA/B⁺ macrophages with multiple immune checkpoints associated with esophageal squamous cell carcinoma (ESCC) liver metastasis

Fei Zheng, Wei Zhang, Baihua Yang, Mingqiu Chen

Annals of Translational Medicine

2022;

(22)

:1249

| https://dx.doi.org/10.21037/atm-22-5351

(November 2022)

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Review Article

Tissue factor as a new target for tumor therapy—killing two birds with one stone: a narrative review

Xiaoying Li, Dan Cao, Xiufeng Zheng, Gang Wang, Ming Liu

Annals of Translational Medicine

2022;

(22)

:1250

| https://dx.doi.org/10.21037/atm-22-5067

(November 2022)

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A narrative review on the development of the ethical review mode of multicenter clinical trials in China

Jing Ding, Yashu Yin, Keke Fang, Wenzhou Zhang, Suxia Luo

Annals of Translational Medicine

2022;

(22)

:1251

| https://dx.doi.org/10.21037/atm-22-5213

(November 2022)

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Special Report

Infection control management strategy for operating room during COVID-19 pandemic

Yihua Dai, Ru Zhang, Yanhua Jiang, Huidan Jin, Jingya Zhao, Anshun Guo, Xian Chen, Dongyi Fan, Lukun Yang

Annals of Translational Medicine

2022;

(22)

:1252

| https://dx.doi.org/10.21037/atm-22-4850

(November 2022)

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Case Report

Creating a re-expanded prefabricated island flap constructed with an anastomosed vascular pedicle for burned ear reconstruction: a case report

Yang Chen, Wanfu Zhang, Fei Han, Xiaolong Hu, Lin Tong, Yunwei Wang, Shaohui Li, Peng Cao, Liwei Dong, Hao Guan

Annals of Translational Medicine

2022;

(22)

:1253

| https://dx.doi.org/10.21037/atm-22-1427

(November 2022)

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The efficacy of oxaliplatin, surufatinib, and camrelizumab on neuroendocrine carcinoma: a case report and literature review

Xianhua Wang, Shaobo Hu, Fei Su, Jie Lin, Jianghui Duan, Haidong Tan, Huangying Tan

Annals of Translational Medicine

2022;

(22)

:1254

| https://dx.doi.org/10.21037/atm-22-4789

(November 2022)

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Hereditary spherocytosis complicated by intrahepatic cholestasis: two case reports

Ning Han, Wei Huang, Juan Wang, Lang Bai, Libo Yan, Hong Tang

Annals of Translational Medicine

2022;

(22)

:1255

| https://dx.doi.org/10.21037/atm-22-5076

(November 2022)

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iMDT Corner

Diabetic ketoacidosis induced by nivolumab in invasive mucinous adenocarcinoma of the lung: a case report and review of the literature

Juan Yan, Zheng-Zheng Xie, Teresa Moran, Cesare Gridelli, Mao-Dong Zheng, Su-Juan Dai

Annals of Translational Medicine

2022;

(22)

:1256

| https://dx.doi.org/10.21037/atm-22-5211

(November 2022)

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Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Effect of tocilizumab treatment in mildly-obese patients with coronavirus disease 2019: a case series

Takashi Abe, Fumihiro Yamaguchi, Shunsuke Sakakura, Yohei Yamazaki, Yusuke Shikama

The beneficial effects of Fomitopsis pinicola chloroform extract on a dextran sulfate sodium-induced ulcerative colitis mice model

Xiaoxia Cheng, Yifan Ji, Xinyi Li, Zijian Wang, Bo Wang, Fengqin He, Shaoan Xue

Construction and validation of a prognostic model based on stage-associated signature genes of head and neck squamous cell carcinoma: a bioinformatics study

Lizhu Chen, Xiaofei Zhang, Jie Lin, Yaoming Wen, Yu Chen, Chuan-Ben Chen

Ophthalmology foundation Ophthalmic Surgical Competency Assessment Rubric (OSCAR) for pterygium surgery

Muhammad Moin, Karl C. Golnik, Sepehr Feizi, Agvaandorj Buyandelger, Rosa E. Adrianzen

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Refinement of a pharmacogenomics app for dosing guidelines for oncology: findings from the usability evaluation

Crystal Dodson, Lucas Layman

Bioinformatics analysis of the prognostic biomarkers and predictive accuracy of differentially expressed genes in high-risk multiple myeloma based on Gene Expression Omnibus database mining

Chenxiao Du, Dongmei Guo, Yuhui Zhang, Chao Gao, Jie Bai

Right vagus nerve stimulation improves motor behavior by exerting neuroprotective effects in Parkinson’s disease rats

Chaofan Wang, Tong Su, Lifei Xiao, Yangyang Wang, Xianhao Huo, Wenchao Li, Jiangwei Ding, Tao Sun

Diagnostic significance of serum type IV collagen (IVC) combined with aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio in liver fibrosis

Airu Niu, Tonggang Qi

SMC4 enhances the chemoresistance of hepatoma cells by promoting autophagy

Shi-Ran Zhang, Jie Li, Jing-Xiang Chen, Geng Chen, Jun-Ying Chen, Hang-Wei Fu, Bo Zhou

Association of CYP2D6 genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery

Soroush Merchant, Cynthia A. Prows, Fang Yang, Lili Ding, Jacob MacDonald, Xue Zhang, Senthilkumar Sadhasivam, Victor Garcia, Peter Sturm, Vidya Chidambaran

Classification of solid pulmonary nodules using a machine-learning nomogram based on ¹⁸F-FDG PET/CT radiomics integrated clinicobiological features

Caiyue Ren, Mingxia Xu, Jiangang Zhang, Fuquan Zhang, Shaoli Song, Yun Sun, Kailiang Wu, Jingyi Cheng

Cost-effectiveness of precision molecular diagnostic tests for stage II colorectal cancer

Vivek S. Chaudhari, Amalia M. Issa

Publication trends of peroral endoscopic myotomy during 2010–2022: a bibliometric analysis

Xin-Yang Liu, Wei-Feng Chen, Meng-Jiang He, Yun-Shi Zhong, Yi-Qun Zhang, Jian-Wei Hu, Li-Qing Yao, Quan-Lin Li, Ping-Hong Zhou

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

The effect of medication reconciliation on generating an accurate medication list in a pharmacogenomics practice

Natasha J. Petry, Joel Van Heukelom, Jordan F. Baye, Amanda Massmann

The economic burden and long-term mortality in survivors of extracorporeal membrane oxygenation in South Korea

Tak Kyu Oh, In-Ae Song

A comparative study about attitudes towards the efficiency, effectiveness, and atmosphere of offline and online learning among medical students

Zhiqiao Jiao, Yongjie Yang, Shuai Zhang, Jing Xu

Development and validation of a random forest model for predicting radiation pneumonitis in lung cancer patients receiving moderately hypofractionated radiotherapy: a retrospective cohort study

Yang Zhang, Zongjuan Li, Han Xiao, Zhenjiang Li, Jian He, Shisuo Du, Zhaochong Zeng

Geometrical analysis of the opening gap after tibial condylar valgus osteotomy for proper hinge point selection

Xiaoyu Wang, Rui Zhang, Xu Zheng, Yifan Yu, Jia Xu, Qinglin Kang

Local surgery improves survival in elderly patients with stage IV breast cancer: a population-based retrospective cohort study

Yongshi Shen, Liuxin Yang, Jinsen Weng, Yiping Zhang, Zhizhong Lin, Qingzhong Lin, Min Xiao, Jingping Lin

Experimental study on stromal vascular fraction mediated inhibition of skin pigmentation in guinea pigs

Jin-Peng Shen, Yong-Xuan Wu, Shi-Jie Tang, Li-Hong Peng

Melatonin improves pregnancy outcomes in adenomyosis mice by restoring endometrial receptivity via NF-κB/apoptosis signaling

Xiaohong Guan, Dan Liu, Hong Zhou, Chaoqun Dai, Tao Wang, Yuan Fang, Yanping Jia, Kunming Li

Review Article

Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis

Jiayu Li, Qi Wang, Honghao Wang

Cone-beam CT in lung biopsy: a clinical practice review on lessons learned and future perspectives

Roel L. J. Verhoeven, Stephan E. P. Kops, Inge N. Wijma, Desi K. M. ter Woerds, Erik H. F. M. van der Heijden

Literature analysis of artificial intelligence in biomedicine

Tim Hulsen

Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review

Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu

Patient-specific airway stent using three-dimensional printing: a review

Carlos Aravena, Thomas R. Gildea

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Reflections from a NMOSD case with serum AQP4-Ab negativity but CSF positivity: narrative review of how to interpret AQP4-Ab test results

Qun Xue, Shugang Cao, Qianyun Rui

The deep inferior epigastric artery perforator flap: a narrative review on its various uses in non-breast reconstruction

Claire Guinier, Eloi de Clermont-Tonnerre, Jing Qin Tay, Zhi Yang Ng, Curtis L. Cetrulo Jr, Alexandre G. Lellouch

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology

Weihua Zhang, Haitao Ren, Xiaotun Ren, Fang Fang, Hongzhi Guan

Narrative review—focal therapy: are we ready to change the prostate cancer treatment paradigm?

Thomas R. Williams, Tavya G. R. Benjamin, Michael J. Schwartz, Ardeshir R. Rastinehad

Narrative review of autoantibodies in idiopathic inflammatory myopathies

Yilin Liu, Yiming Zheng, Hongjun Hao, Yun Yuan

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Focal cryotherapy for prostate cancer: a contemporary literature review

Srinath Kotamarti, Thomas J. Polascik

Emerging therapies for non-small cell lung cancer harboring EGFR exon 20 insertion mutations: narrative review

Naohiro Watanabe, Yoshitsugu Horio, Yutaka Fujiwara

Research progress on febrile non-hemolytic transfusion reaction: a narrative review

Hekong Wang, Dangli Ren, Hongtao Sun, Jiqin Liu

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Uniportal pure robotic-assisted thoracic surgery—technical aspects, tips and tricks

Diego Gonzalez-Rivas, Veronica Manolache, Mugurel Liviu Bosinceanu, Javier Gallego-Poveda, Alejandro Garcia-Perez, Mercedes de la Torre, Akif Turna, Natalia Motas

Bronchiectasis exacerbation: a narrative review of causes, risk factors, management and prevention

Hayoung Choi, James D. Chalmers

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

Optimal validation of accuracy in antibody assays and reasonable definition of antibody positive/negative subgroups in neuroimmune diseases: a narrative review

Hai-Feng Li

Case Report

Raltitrexed as a substitute for capecitabine in metastatic gastric cancer: a case report and literature review

Imran Ladak, Beatrice Preti, Bryan Dias, Daniel Adam Breadner

Targeting chromosome 12q amplification in relapsed glioblastoma: the use of computational biological modeling to identify effective therapy—a case report

Michael P. Castro, Negar Khanlou, Aria Fallah, Anusha Pampana, Aftab Alam, Deepak Anil Lala, Kunal Ghosh Ghosh Roy, Anish Raju R. Amara, Annapoorna Prakash, Divya Singh, Liptimayee Behura, Ansu Kumar, Shweta Kapoor

Symptomatic spinal cord compression in spinal epidural metastasis of a testicular germ cell tumor: a case report with review of the literature

Najwa Chebli, Mustapha Dahiri, Halima Ahmut, Meryem El Aamraoui, Saad Lannaz, Ibrahim El Ghissassi, Saber Boutayeb, Hind Mrabti, Hassan Errihani

A case report and literature review: subcutaneous panniculitis-like T-cell lymphoma with liver failure as the main manifestation

Sike He, Neng Wang, Jiaming Feng, Xin He, Ying Wang, Liyu Chen

Non-small cell lung cancer with MET exon 14 skip mutation: case report

Wolfgang Clough, Mira Al Jaberi, Samir Dalia

Role of conservative therapy prior to surgery in xanthogranulomatous mastitis: a case report

Yong Min Lee, Anurag Gupta, Jennie Gu, Nara Lee

Atypical endoscopic finding of colocolic intussusception: case report and literature review

Keng Hoong Chiam, Sumithra Sannasey, Sandhya Rajaintharan, Raman Muthukaruppan

Editorial

Medication reconciliation to support pharmacogenomics implementation

Scott A. Mosley, Joshua M. Pevnick

Unraveling the genetic architecture of asthma

Natalia Hernandez-Pacheco, Erik Melén

Asthmatic airway remodeling: long overlooked but too important to ignore

Amanda L. Tatler

Editorial Commentary

Neoantigen personalized vaccine plus anti-PD-1 antibody in cancer patients

María González-Cao, Rafael Rosell

A commentary on the potential of smartphones and other wearable devices to be used in the identification and monitoring of mental illness

Lianne Koinis, Ralph Jasper Mobbs, R. Dineth Fonseka, Pragadesh Natarajan

Should we test for SLCO1B1 genotype before prescribing statins? A discussion of clinical trial results

Yitian Zhou, Volker M. Lauschke

Pharmacogenetic screening in a knowledge-based economy: shouldn’t more be better?

David A. Alter

Offering a putative neurobiological “dopamine homeostatic” solution to overcome the perils of the reward deficiency syndrome pandemic: emergence of “precision behavioral management”

Kenneth Blum, Catherine A. Dennen, David Baron, Panayotis K. Thanos, Rajendra D. Badgaiyan

Racial and ethnic disparities in breast cancer survival: critical appraisal of the data emerging from the randomized TAILORx

Gianluca Franceschini, Armando Orlandi

Difficult airway management in the operation room (OR): American and French guidelines discrepancies are they so important?

Hervé Quintard, Olivier Langeron

Association of TP53 clonal hematopoiesis with indeterminate potential with the development of myeloid neoplasms after rucaparib treatment

Reiko Yoshida, Seigo Nakamura

Does race/ethnicity influence the impact of new glucose-lowering agents on cardiovascular outcomes? a comparison between Asian versus White patients

André J. Scheen

Race, ethnicity, and clinical outcomes in hormone receptor-positive, human epidermal growth factor 2 negative (HER2−), node negative breast cancer in the randomized TAILORx trial: gaps in biologic and social determinants of health

Ana-Alicia Beltran-Bless, Terry L. Ng

Erratum

Erratum to correlation between gut bacteria Phascolarctobacterium and exogenous metabolite α-linolenic acid in T2DM: a case-control study

Editorial Office

Tutorial

Tutorial: implementing and visualizing machine learning (ML) clinical prediction models into web-accessible calculators using Shiny R

Hyrum S. Eddington, Amber W. Trickey, Vaibhavi Shah, Alex H. S. Harris

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

Over the year, many ATM reviewers have made outstanding contributions to the peer review process. More >>

Announcement more

New Impact Factor for Annals of Translational Medicine: 3.616

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2021 citation year: 3.616. More >>

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

From bud to blossom: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in Annals of Translational... More >>

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