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New Impact Factor for Annals of Translational Medicine: 3.616

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2021 citation year: 3.616.

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

While China’s academic field is flourishing, ATM is blooming and become a choice of publication venue for more and more recognized affiliations. For ATM, it is precisely a type of recognition—by the country's top academic institutions and the most important think tanks in the country in the form of publication venue choice—that makes ATM stay in the scientific research fronts and able to further realize its mission of translating between bench and bedside. ATM's educational value is mostly based on the objective opinions of a group of field experts within the scientific community.

Novel Tools and Therapies for Ocular Regeneration

This special series is very timely since there has been a recent increase in the momentum of translational research in ocular regeneration. This increase stems partially from the success of ocular gene therapy. This special eye series includes review and original articles of novel tools and therapies being developed for ocular regeneration. The goal of this eye series is to provide some overview of the latest research being done in the area of ocular regeneration in order to highlight the broad potential in this field.

Endovascular Interventions in Trauma

Trauma is a leading cause of death and disability and predominately effects young patients. Trauma teams include many health care professionals from many subspecialties. Endovascular specialists such as interventional radiologists and vascular surgeons play an ever growing role in this team and in the care of these patients. In this focused series on endovascular interventions in trauma, articles will discuss the endovascular treatment of traumatic aortic injury, splenic, hepatic, renal pelvic and extremity trauma. Additionally, we include an article on the emerging technology of resuscitative endovascular balloon occlusion of the aorta (REBOA).

Highlights in Anesthesia and Critical Care Medicine (Ongoing)

Guest Editors: Tobias Eckle and Benjamin Scott (Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA)

Challenges in Clinical Trials (Ongoing)

This special series on “Challenges in Clinical Trials” is edited by Dr. Weiping Wen, Dr. Yanhong Deng, Dr. Qian Shi and Dr. Jun (Vivien) Yin. As with any industry, the challenges facing those working in clinical trials are numerous: from patient recruitment, adoption of technology, regulatory requirements, and spiraling costs. This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.

Lung Cancer Management—The Next Decade (Ongoing)

This special series on “Lung Cancer Management—The Next Decade” is edited by Dr. Calvin S. H. Ng. Lung cancer remains a disease associated with high morbidity and mortality. It is only in the past decade or so that newer forms of therapies have gradually become available. Targeted and immunotherapies, specialized radiation ion therapies; and operative approaches that are more tailored to the individual with improved precision and lower surgical trauma have been in rapid development.

ATM Annual Report 2021

Greetings from the editorial office of ATM. We wish you a happy new year in 2022. In 2021, ATM has made great progress under the joint-efforts of experts worldwide.

- More than 1800 papers have been published in ATM in 2021.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,860,685 times in 2021.
- The number of total citations by SCI journals has significantly increased to 36,500 till December 2021.
- The pageviews of ATM journal website is increasing significantly, with a total of 2,869,820 hits in 2021.

Carotid Artery Stenosis and Stroke-Prevention and Treatment Part II

Prevention and treatment of ischemic carotid-related strokes is a research priority. All controversial issues should be addressed to optimize patient outcomes. The current series are the second part of two series on the prevention and treatment of carotid artery stenosis and carotid-related strokes. Hopefully, these two series will help to answer many of the current questions and to resolve some of the controversial issues on the topic.

Annals of Translational Medicine (ATM) is now a member of Committee on Publication Ethics (COPE)

Clubfoot

This special series, thanks to the enthusiastic participation of many experts in the field, tries to give a comprehensive overview of the clubfoot pathology, and an objective analysis of the outcome of treatments. The members of leading medical- surgical teams dedicated to the care of children with clubfoot agreed to share their experience and their thoughts on the subject, making this series of articles a unique document summarizing the ‘state of the art’ of clubfoot treatment and its outcome in different part of the world.

Cancer Immunotherapy: Recent Advances and Challenges

In this focused series, we celebrate the success of T-cell targeted agents and provide a comprehensive overview of challenges with cancer immunotherapy. Discussed topics include immune-related adverse events and financial toxicities, safety concerns in patients with pre-existing immune dysfunction, current and emerging biomarkers of response along with a detailed discussion on the role of the gut microbiome in modulating response to ICI. Other reviewed topics include chimeric antigen receptor T-cell (CAR T-cell) therapy and ICI in lymphoid malignancies, clinical studies exploring ways to turn immunologically inert “cold” sarcomas “hot’’ and intralesional agents in the treatment of malignant melanoma.

Hyperthermic Intraoperative Chemotherapy (HITHOC) in Thoracic Surgical Oncology

This series of ATM makes an important contribution to this subject as patients, surgeons, physicians, oncologists after reading the various articles published in the series will be hugely informed on HITHOC as an adjuvant treatment to cytoreductive surgery of primary and metastatic thoracic cancers such as mesothelioma, M1a-pleural effusion lung cancer, advanced thymomas and metastatic cancers.

Rheumatologic Skin Disease

The content of the narrative reviews in this Series was designed to provide non-dermatologist readers with a better perspective on the value of clinical observation and translational research focused on the cutaneous manifestations of genetically-complex, environmentally-impacted and variably-expressed human illnesses such as the autoimmune connective tissue diseases.

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Vol 10, No 12 (June, 2022)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

The impact of autostereoscopic screens on assessing depth perception

Robert W. Arnold

Annals of Translational Medicine

2022;

(12)

:653

| https://dx.doi.org/10.21037/atm-2022-14

(June 2022)

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Deep-learning algorithms for choroidal thickness measurements in high myopia

Francisco de Asís Bartol-Puyal, Luis Pablo Júlvez

Annals of Translational Medicine

2022;

(12)

:654

| https://dx.doi.org/10.21037/atm-22-2551

(June 2022)

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Is it time to retire sentinel lymph node biopsy and use multi-omics prediction models?

Rosalind Kieran, Mehmet Goksu, Susanne Crocamo, Bruno de Paula

Annals of Translational Medicine

2022;

(12)

:655

| https://dx.doi.org/10.21037/atm-2022-21

(June 2022)

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Original Article

A novel clinical dynamic stereopsis assessment based on autostereoscopic display system

Yiyao Wang, Jing Zhong, Mengyi Cheng, Jijing Li, Ke Ma, Xiaoqing Hu, Naiyang Li, Haowen Liang, Zhengyuan Zhu, Jianying Zhou, Jin Yuan

Annals of Translational Medicine

2022;

(12)

:656

| https://dx.doi.org/10.21037/atm-21-6700

(June 2022)

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Comparison of the efficacy and safety of caplacizumab versus placebo in thrombotic thrombocytopenic purpura: a meta-analysis and systematic review based on randomized controlled trials

Bin Chen, Xihong Li, Dongqiong Xiao, Rodrigo Daminello Raimundo, Ruixi Zhou, Yupeng Lei

Annals of Translational Medicine

2022;

(12)

:657

| https://dx.doi.org/10.21037/atm-22-2847

(June 2022)

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Correlation of the characteristics of symptomatic intracranial atherosclerotic plaques with stroke types and risk of stroke recurrence: a cohort study

Huayun Jiang, Kaixuan Ren, Tiantian Li, Chengqun Qian, Shenchu Gong, Tianle Wang, Li Zhu

Annals of Translational Medicine

2022;

(12)

:658

| https://dx.doi.org/10.21037/atm-22-2586

(June 2022)

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Lung transplantation for bronchiolitis obliterans after hematopoietic stem cell transplantation: a retrospective single-center study

Jialong Liang, Yuan Chen, Jintao Zhou, Huixing Li, Mingfeng Zheng, Feng Liu, Shugao Ye, Jingyu Chen, Yong Ji

Annals of Translational Medicine

2022;

(12)

:659

| https://dx.doi.org/10.21037/atm-22-2517

(June 2022)

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Clinical efficacy of endoscopic antireflux mucosectomy vs. Stretta radiofrequency in the treatment of gastroesophageal reflux disease: a retrospective, single-center cohort study

Xinke Sui, Xiaopei Gao, Lu Zhang, Bin Zhang, Changqing Zhong, Yan Chen, Xiaoying Wang, Dou Li, Wei Wu, Lianyong Li

Annals of Translational Medicine

2022;

(12)

:660

| https://dx.doi.org/10.21037/atm-22-2071

(June 2022)

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Seronegative rheumatic arthritis has milder inflammation and bone erosion in an ultrasound study of disease-modifying anti-rheumatic drugs (DMARDs)-naïve Chinese cohort

Dongfang Lin, Minjing Zhao, Yanli Zhang, Ya Xie, Junyan Cao, Yunfeng Pan

Annals of Translational Medicine

2022;

(12)

:661

| https://dx.doi.org/10.21037/atm-22-2171

(June 2022)

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Soluble guanylate cyclase (sGC) stimulator vericiguat alleviates myocardial ischemia-reperfusion injury by improving microcirculation

Yun Cai, Beijian Zhang, Adilan Shalamu, Tingwen Gao, Junbo Ge

Annals of Translational Medicine

2022;

(12)

:662

| https://dx.doi.org/10.21037/atm-22-2583

(June 2022)

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Down-regulated expression of miR-99a is associated with lymph node metastasis and predicts poor outcome in stage IB cervical squamous cell carcinoma: a case-control study

Gongyi Zhang, Rong Zhang, Ping Bai, Shumin Li, Jing Zuo, Yuanyuan Zhang, Mei Liu, Lingying Wu

Annals of Translational Medicine

2022;

(12)

:663

| https://dx.doi.org/10.21037/atm-22-2483

(June 2022)

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Effectiveness and safety of decompression alone versus decompression plus fusion for lumbar spinal stenosis with degenerative spondylolisthesis: a systematic review and meta-analysis

Zhubin Shen, Xiaojing Guan, Rui Wang, Qian Xue, Ding Zhang, Yuan Zong, Wenxuan Ma, Ruijian Zhuge, Zhiming Liu, Changhao He, Li Guo, Fei Yin

Annals of Translational Medicine

2022;

(12)

:664

| https://dx.doi.org/10.21037/atm-22-2208

(June 2022)

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Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis

Zhefan Xie, Tingting Xia, Dongxue Wu, Li Che, Wei Zhang, Xingdong Cai, Shengming Liu

Annals of Translational Medicine

2022;

(12)

:665

| https://dx.doi.org/10.21037/atm-22-2523

(June 2022)

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The predictive value of tumor volume reduction ratio on three-dimensional endorectal ultrasound for tumor response to chemoradiotherapy for locally advanced rectal cancer

Limei Chen, Xiaoyin Liu, Wenjing Zhang, Si Qin, Yimin Wang, Jing Lin, Qiu Chen, Guangjian Liu

Annals of Translational Medicine

2022;

(12)

:666

| https://dx.doi.org/10.21037/atm-22-2418

(June 2022)

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The effects of dexmedetomidine on the cognitive function of mild cognitive impairment (MCI) rats

Qian Zhou, Dongjin Xie, Ting Chen, Youguang Gao, Lanying Lin, Xianzhong Lin

Annals of Translational Medicine

2022;

(12)

:667

| https://dx.doi.org/10.21037/atm-22-2043

(June 2022)

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Diagnostic study on clinical feasibility of an AI-based diagnostic system as a second reader on mobile CT images: a preliminary result

Kaiyue Diao, Yuntian Chen, Ying Liu, Bo-Jiang Chen, Wan-Jiang Li, Lin Zhang, Ya-Li Qu, Tong Zhang, Yun Zhang, Min Wu, Kang Li, Bin Song

Annals of Translational Medicine

2022;

(12)

:668

| https://dx.doi.org/10.21037/atm-22-2157

(June 2022)

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Bioinformatics analysis identifies diagnostic biomarkers and their correlation with immune infiltration in diabetic nephropathy

Menglan Huang, Zhengxi Zhu, Cong Nong, Zhao Liang, Jingxue Ma, Guangzhi Li

Annals of Translational Medicine

2022;

(12)

:669

| https://dx.doi.org/10.21037/atm-22-1682

(June 2022)

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Evaluation of the impact of reference tooth morphology and alignment on model measurement accuracy

Zhi Mao, Yi-Fan Jia, Yi-Fan Zhang, Jing Xu, Zhi-Na Wu, Feng Mao, Yi Zhang, Min Hu

Annals of Translational Medicine

2022;

(12)

:670

| https://dx.doi.org/10.21037/atm-22-2497

(June 2022)

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Network pharmacology-based analysis of the effects of puerarin on sarcopenia

Xufeng Chen, Yan Wang, Meige Liu, Xiaodong Song, Dong Wang, Jun Zhang

Annals of Translational Medicine

2022;

(12)

:671

| https://dx.doi.org/10.21037/atm-22-2360

(June 2022)

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Application of metagenomic next-generation sequencing for the diagnosis of intracranial infection of Listeria monocytogenes

Jing Li, You Zhang, Quanquan Zhang, Shiqi Lu, Fang Huang, Jun Wang

Annals of Translational Medicine

2022;

(12)

:672

| https://dx.doi.org/10.21037/atm-22-2186

(June 2022)

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Improvement of surgical techniques for orthotopic single lung transplantation in rats

Peigen Gao, Chongwu Li, Ye Ning, Junqi Wu, Pei Zhang, Xiucheng Liu, Yiliang Su, Deping Zhao, Chang Chen

Annals of Translational Medicine

2022;

(12)

:673

| https://dx.doi.org/10.21037/atm-22-2018

(June 2022)

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Bortezomib, epirubicin, and dexamethasone (PAD) results in superior free-progression survival compared to bortezomib, cyclophosphamide, and dexamethasone (VCD) treatment in non-transplantation newly diagnosed multiple myeloma patients aged between 50 to 65: a retrospective single-center analysis in non-transplant patients

Liang Chen, Ke Yi, Hongyan Lan, Yajun Zhang, Simin Jin, Xiaoyu Mou, Hongming Xian, Weijun Fu, Rong Li

Annals of Translational Medicine

2022;

(12)

:674

| https://dx.doi.org/10.21037/atm-22-394

(June 2022)

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Development and validation of a nomogram based on the hospital information system for quantitative assessment of the risk of cardiocerebrovascular complications of diabetes

Xin Xi, Guizhi Yin, Xiaoyong Wang, Xuesong Li

Annals of Translational Medicine

2022;

(12)

:675

| https://dx.doi.org/10.21037/atm-22-2439

(June 2022)

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A prediction model with measured sentiment scores for the risk of in-hospital mortality in acute pancreatitis: a retrospective cohort study

Zhanxiao Liu, Ya Yang, Huanhuan Song, Ji Luo

Annals of Translational Medicine

2022;

(12)

:676

| https://dx.doi.org/10.21037/atm-22-1613

(June 2022)

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Total flavones from Sceptridium ternatum alleviate pulmonary hypertension through inhibiting the proliferation of vascular endothelial cells

Qinglin Li, Wenxiu Xin, Haiyin Ding, Yiwen Zhang, Xiaowei Zheng, Yujia Liu, Ping Huang

Annals of Translational Medicine

2022;

(12)

:677

| https://dx.doi.org/10.21037/atm-21-5889

(June 2022)

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Establishing a predictive model of hypoparathyroidism after total thyroidectomy and central lymph node dissection for postoperative calcium supplementation selectively

Tao Huang, Xiang Zhong, Tianyi He, Wei Zhang, Zhixian He

Annals of Translational Medicine

2022;

(12)

:678

| https://dx.doi.org/10.21037/atm-22-1779

(June 2022)

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Aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism: a systematic review and meta-analysis

Hongjiao Gao, Rong Luo, Jindie Li, Haoming Tian

Annals of Translational Medicine

2022;

(12)

:679

| https://dx.doi.org/10.21037/atm-22-2272

(June 2022)

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Bioinformatics analysis combined with experiments to verify potential autophagy genes in wound healing

Yong-Fang Wu, Da-Lang Fang, Jie Wei

Annals of Translational Medicine

2022;

(12)

:680

| https://dx.doi.org/10.21037/atm-22-2033

(June 2022)

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Exogenous H2S promotes ion channel reconstruction to regulate colonic motility in rats with dinitrobenzene sulfonic acid-induced colitis

Ying Liu, Ribin Liao, Zhanrong Qiang, Wenjun Yang, Jie Cao

Annals of Translational Medicine

2022;

(12)

:681

| https://dx.doi.org/10.21037/atm-22-2126

(June 2022)

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Developing a prediction model for estimating adrenocorticotropic hormone changes in patients undergoing scheduled open hepatectomy

Yu Guan, Jie Tang, Jiali Yu, Yiqi Zhu, Ailun Li, Fang Fang, Jing Cang

Annals of Translational Medicine

2022;

(12)

:682

| https://dx.doi.org/10.21037/atm-22-2276

(June 2022)

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MiR-20a: a mechanosensitive microRNA that regulates fluid shear stress-mediated osteogenic differentiation via the BMP2 signaling pathway by targeting BAMBI and SMAD6

Zhuli Peng, Zhihui Mai, Feng Xiao, Guanqi Liu, Yixuan Wang, Shanshan Xie, Hong Ai

Annals of Translational Medicine

2022;

(12)

:683

| https://dx.doi.org/10.21037/atm-22-2753

(June 2022)

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Efficacy and safety of Sanfeng Tongqiao Diwan in patients with allergic rhinitis: a single-arm clinical trial in China

Haisheng Hu, Jiaying Luo, Jing Ma, Zhiman Liang, Jinyu Dai, Wenxin Wang, Jinglin Zhong, Loushi Tian, Baoqing Sun

Annals of Translational Medicine

2022;

(12)

:684

| https://dx.doi.org/10.21037/atm-22-2768

(June 2022)

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Protective effects of muscone on traumatic spinal cord injury in rats

Chao Yu, Fei Gui, Qian Huang, Yuanmeng Luo, Zili Zeng, Ruifu Li, Liang Guo

Annals of Translational Medicine

2022;

(12)

:685

| https://dx.doi.org/10.21037/atm-22-2672

(June 2022)

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Establishment and validation of analytical methods for 15 hazardous drugs by UPLC-Q/Orbitrap-HRMS

Bo Yu, Yang Wang, Zhou Geng, Yuchen Qu, Jie Pan, Qing Zhai

Annals of Translational Medicine

2022;

(12)

:686

| https://dx.doi.org/10.21037/atm-22-2330

(June 2022)

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Influencing factors of and multiple paths to high performance in multidisciplinary scientific research cooperation in colleges in China: a fuzzy-set qualitative comparative analysis

Jing Xue, Xing Liu, Qun Qin, Weihong Huang, Song Feng, Hua Guo

Annals of Translational Medicine

2022;

(12)

:687

| https://dx.doi.org/10.21037/atm-22-2639

(June 2022)

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The efficacy and safety of self-administered acupressure on respiratory tract infection in chronic kidney disease: a randomized controlled trial

Meifang Liu, Hongqin Sheng, Jiahui Huang, Meiling Xuan, Wenwei Ouyang, Yanmei Zhang, Shuzhen Zhou, Lu Zeng, Lizhe Fu, Yin Chen, Xinyi Huang, Kaiqi Huang, Yifan Wu, Xusheng Liu, Lei Zhang

Annals of Translational Medicine

2022;

(12)

:688

| https://dx.doi.org/10.21037/atm-22-2376

(June 2022)

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CD44 potentiates hepatocellular carcinoma migration and extrahepatic metastases via the AKT/ERK signaling CXCR4 axis

Peiyi Xie, Jiuliang Yan, Mengyuan Wu, Hui Li, Zheng Chen, Mincheng Yu, Bo Zhang, Lingli Chen, Lei Jin, Binghai Zhou, Xiaoqiang Li, Yongsheng Xiao, Yongfeng Xu, Jiang Long, Jubo Zhang, Lei Guo

Annals of Translational Medicine

2022;

(12)

:689

| https://dx.doi.org/10.21037/atm-22-2482

(June 2022)

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Intrinsic network changes associated with cognitive impairment in patients with hearing loss and tinnitus: a resting-state functional magnetic resonance imaging study

Xiaobo Ma, Wei Li, Qian Wang, Xueying He, Xiaoxia Qu, Ting Li, Lirong Zhang, Zhaohui Liu

Annals of Translational Medicine

2022;

(12)

:690

| https://dx.doi.org/10.21037/atm-22-2135

(June 2022)

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Icariin promotes the repair of bone marrow mesenchymal stem cells in rabbit knee cartilage defects via the BMP/Smad pathway

Feng Jiao, Wang Tang, Jie Wang, Donghua Liu, Hongyi Zhang, Dongming Tang

Annals of Translational Medicine

2022;

(12)

:691

| https://dx.doi.org/10.21037/atm-22-2515

(June 2022)

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Evaluation on clinical performance of the new low-value platelet measurement mode (PLT-8X) of BC-6800Plus

Yimin Shen, Dongmei Liu, Yong Wang, Jun Cao, Shuaishuai Zhang, Hui Wen, Qiuqiu Dong, Dong Zheng, Jun Qiu

Annals of Translational Medicine

2022;

(12)

:692

| https://dx.doi.org/10.21037/atm-22-1501

(June 2022)

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Midkine promotes kidney injury in diabetic kidney disease by increasing neutrophil extracellular traps formation

Gaohong Liu, Xiaojun Ren, Yousong Li, Han Li

Annals of Translational Medicine

2022;

(12)

:693

| https://dx.doi.org/10.21037/atm-22-2382

(June 2022)

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Development and external validation of prognostic nomograms for liver disease-free and overall survival in locally advanced rectal cancer with neoadjuvant therapy: a post cohort study based on the FOWARC trial

Jiaming Zhou, Tuoyang Li, Yuanlv Xiao, Jinxin Lin, Xiaoqiong Chen, Shaoyong Peng, Mingzhe Huang, Xuebin Shi, Linbin Cai, Pinzhu Huang, Meijin Huang

Annals of Translational Medicine

2022;

(12)

:694

| https://dx.doi.org/10.21037/atm-22-2790

(June 2022)

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Down-regulation of LCN2 attenuates retinal vascular dysfunction and caspase-1-mediated pyroptosis in diabetes mellitus

Xingjie Su, Pingping Zhou, Yanxiu Qi

Annals of Translational Medicine

2022;

(12)

:695

| https://dx.doi.org/10.21037/atm-22-2655

(June 2022)

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WX-0593 combined with an epithelial growth factor receptor (EGFR) monoclonal antibody in the treatment of xenograft tumors carrying triple EGFR mutations

Qingmei Zheng, Dongmei Chen, Xinmei Wang, Yingying Yang, Shuyong Zhao, Xin Dong, Cuicui Ma, Xin Zhang, Huicheng Duan, Yan Sun, Shansong Zheng

Annals of Translational Medicine

2022;

(12)

:696

| https://dx.doi.org/10.21037/atm-22-2780

(June 2022)

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Study on the clinical features and prognosis of second and third generations of COVID-19

Chao Deng, Liping Chen, Chao Ji, Yaoming Yuan, Yu Hou, Jinghui Li

Annals of Translational Medicine

2022;

(12)

:697

| https://dx.doi.org/10.21037/atm-22-1819

(June 2022)

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Bioinformatic analysis of cancer-associated fibroblast related gene signature as a predictive model in clinical outcomes and immune characteristics of gastric cancer

Jiehao Zhang, Nannan Zhang, Xin Fu, Weizhen Wang, Hui Liu, Michael J. McKay, Pornngarm Dejkriengkraikul, Yongzhan Nie

Annals of Translational Medicine

2022;

(12)

:698

| https://dx.doi.org/10.21037/atm-22-2810

(June 2022)

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Systemic glucocorticoid-free therapy with adalimumab plus immunosuppressants versus conventional therapy in treatment-naïve Vogt-Koyanagi-Harada disease patients

Shizhao Yang, Tianyu Tao, Zhaohuai Li, Binyao Chen, Zhaohao Huang, Xiuxing Liu, He Li, Lihui Xie, Wen Feng, Wenru Su

Annals of Translational Medicine

2022;

(12)

:699

| https://dx.doi.org/10.21037/atm-22-2668

(June 2022)

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Anti-atherosclerotic effects of genistein in preventing ox-low-density lipoprotein-induced smooth muscle-derived foam cell formation via inhibiting SRC expression and L-Ca channel currents

Wei Zhang, Liming Zhang, Xiaosi Zhang

Annals of Translational Medicine

2022;

(12)

:700

| https://dx.doi.org/10.21037/atm-22-2113

(June 2022)

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Bioinformatics analysis of SOXF family genes reveals potential regulatory mechanism and diagnostic value in cancers

Dan Wu, Chuan Jiang, Jing-Jing Zheng, De-Sheng Luo, Ji Ma, Hai-Feng Que, Chao Li, Chao Ma, Hui-Yong Wang, Wei Wang, Hong-Tao Xu

Annals of Translational Medicine

2022;

(12)

:701

| https://dx.doi.org/10.21037/atm-22-2749

(June 2022)

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Prognostic impact of high-risk factors and KRAS mutation in patients with stage II deficient mismatch repair colon cancer: a retrospective cohort study

Yuting Zhang, Zehua Wu, Bin Zhang, Huabin Hu, Jianwei Zhang, Yi Chen, Miaomiao Ding, Yabing Cao, Yanhong Deng

Annals of Translational Medicine

2022;

(12)

:702

| https://dx.doi.org/10.21037/atm-22-2803

(June 2022)

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Clinical study of poorly differentiated head and neck squamous cell carcinoma: a prospective cohort study in China

Shuo Ding, Wei Guo, Gaofei Yin, Nuan Li, Hongfei Liu, Junwei Huang, Zheng Yang, Hongbo Xu, Xiaohong Chen, Yang Zhang, Zhigang Huang

Annals of Translational Medicine

2022;

(12)

:703

| https://dx.doi.org/10.21037/atm-22-2630

(June 2022)

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The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial

Yanbing Su, Jianxing Zhang, Huanwei Wang, Yangkui Gu, Handong Ouyang, Wan Huang

Annals of Translational Medicine

2022;

(12)

:704

| https://dx.doi.org/10.21037/atm-22-2756

(June 2022)

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Docetaxel population pharmacokinetic modelling and simulation in Chinese cancer patients

Jian Wei, Yuwen Zhang, Ze Li, Xingang Li, Chenglong Zhao

Annals of Translational Medicine

2022;

(12)

:705

| https://dx.doi.org/10.21037/atm-22-2619

(June 2022)

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Next-generation sequencing and targeted quantitative real-time polymerase chain reaction for detection of Akebiae Caulis in the traditional Chinese medical formula Longdan Xiegan Wan

Yinsen Song, Zhenzhen Yang, Peipei Wang, Ke Song, Sisen Zhang, Tianli Fan

Annals of Translational Medicine

2022;

(12)

:706

| https://dx.doi.org/10.21037/atm-22-2415

(June 2022)

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Molecular mechanism of betulin palliative therapy for chronic obstructive pulmonary disease (COPD) based on P2X7 receptor target of gated ion channel

Pengfei Jiao, Yingrui Wang, Tianqing Sang, Jing Jiao, Yameng Li

Annals of Translational Medicine

2022;

(12)

:707

| https://dx.doi.org/10.21037/atm-22-2629

(June 2022)

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Efficacy and safety of combined treatment with pembrolizumab in patients with locally advanced or metastatic esophageal squamous cell carcinoma in the real world

Pei Zhang, Xiaobin Hou, Boning Cai, Wei Yu, Jing Chen, Xiang Huang, Ye Li, Mingyue Zeng, Zhipeng Ren, Emmanuel Gabriel, Baolin Qu, Fang Liu

Annals of Translational Medicine

2022;

(12)

:708

| https://dx.doi.org/10.21037/atm-22-2779

(June 2022)

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Does pretreatment elevated calcitonin level cause the poor prognosis in patients with medullary thyroid cancer?

Han Zhang, Daqi Zhang, Chengqiu Sui, Jingting Li, Canxiao Li, Qiao He, Rui Du, Yishen Zhao, Yantao Fu, Le Zhou, Tie Wang, Gianlorenzo Dionigi, Nan Liang, Hui Sun

Annals of Translational Medicine

2022;

(12)

:709

| https://dx.doi.org/10.21037/atm-22-2737

(June 2022)

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Effect of micro-arc oxidation surface modification of 3D-printed porous titanium alloys on biological properties

Renhua Ni, Zehao Jing, Chenao Xiong, Dexuan Meng, Chongbin Wei, Hong Cai

Annals of Translational Medicine

2022;

(12)

:710

| https://dx.doi.org/10.21037/atm-22-2536

(June 2022)

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Review Article

Gene polymorphisms in asthma: a narrative review

Fei Shi, Yu Zhang, Chen Qiu

Annals of Translational Medicine

2022;

(12)

:711

| https://dx.doi.org/10.21037/atm-22-2170

(June 2022)

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DDX5: an expectable treater for viral infection- a literature review

Minghui Hu, Hongying Zheng, Jingqi Wu, Yue Sun, Tianying Wang, Shuang Chen

Annals of Translational Medicine

2022;

(12)

:712

| https://dx.doi.org/10.21037/atm-22-2375

(June 2022)

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Narrative review of the relationship between the maternal-fetal interface immune tolerance and the onset of preeclampsia

Fangyuan Luo, Jun Yue, Lingling Li, Jie Mei, Xinghui Liu, Yu Huang

Annals of Translational Medicine

2022;

(12)

:713

| https://dx.doi.org/10.21037/atm-22-2287

(June 2022)

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Application and interpretation of vessel wall magnetic resonance imaging for intracranial atherosclerosis: a narrative review

Fangbing Li, Yilin Wang, Tianxiang Hu, Yejun Wu

Annals of Translational Medicine

2022;

(12)

:714

| https://dx.doi.org/10.21037/atm-22-2364

(June 2022)

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Design and optimization of auditory prostheses using the finite element method: a narrative review

Qianli Cheng, Han Yu, Junpei Liu, Qi Zheng, Yanru Bai, Guangjian Ni

Annals of Translational Medicine

2022;

(12)

:715

| https://dx.doi.org/10.21037/atm-22-2792

(June 2022)

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A narrative review of cortical visual prosthesis systems: the latest progress and significance of nanotechnology for the future

Xi Liu, Peipei Chen, Xuemeng Ding, Anning Liu, Peng Li, Cheng Sun, Huaijin Guan

Annals of Translational Medicine

2022;

(12)

:716

| https://dx.doi.org/10.21037/atm-22-2858

(June 2022)

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Study Protocol

Developing the RIGHT-COI&F extension for the reporting conflicts of interest and funding in practice guidelines: study protocol

Yangqin Xun, Janne Estill, Mengjuan Ren, Ping Wang, Nan Yang, Zijun Wang, Ying Zhu, Renfeng Su, Yaolong Chen, Elie A. Akl

Annals of Translational Medicine

2022;

(12)

:717

| https://dx.doi.org/10.21037/atm-22-2123

(June 2022)

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Case Report

Successful secondary radical operation on unretractable metastatic platinum-sensitive recurrent ovarian cancer by immunotherapy: a case report

Li Sun, Hua Li, Sulan Wei, Meng Yang, Shaoqiong Deng

Annals of Translational Medicine

2022;

(12)

:718

| https://dx.doi.org/10.21037/atm-22-2128

(June 2022)

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Two case reports of non-small cell lung cancer patients harboring acquired EGFR T790M-cis-C797S benefit from immune checkpoint inhibitor combined with platinum-based doublet chemotherapy

Zizheng Song, Guanying Ren, Ling Hu, Xiaolei Wang, Jin Song, Youchao Jia, Guofa Zhao, Aimin Zang, Haiwei Du, Ying Sun, Xiaopeng Zhao

Annals of Translational Medicine

2022;

(12)

:719

| https://dx.doi.org/10.21037/atm-22-2436

(June 2022)

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Percutaneous full endoscopic C1 laminectomy for developmental atlantal stenosis with myelopathy: a case report of three cases and review of the literature

Yongpeng Lin, Siyuan Rao, Bingxin Liu, Yueli Sun, Shuai Zhao, Guoyi Su, Shudong Chen, Yongjin Li, Bolai Chen

Annals of Translational Medicine

2022;

(12)

:720

| https://dx.doi.org/10.21037/atm-22-2282

(June 2022)

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Clinical observation of allergic contact stomatitis treated with Kangfuxin solution as adjuvant: case report

Xiaoyi Zang, Wenjuan Du, Funeng Geng, Panpan Meng, Lingling E, Haizhong Zhang, Xinling Wang, Lin Li, Rui Xiao

Annals of Translational Medicine

2022;

(12)

:721

| https://dx.doi.org/10.21037/atm-22-2734

(June 2022)

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A case report of the metagenomics next-generation sequencing for early detection of central nervous system mucormycosis with successful rescue in patient with recurrent chronic lymphocytic leukemia

Jiaojiao Zhang, Jing Luo, Xiangqin Weng, Yongmei Zhu, Gaurav Goyal, Fabiana Perna, Manuel Espinoza-Gutarra, Lu Jiang, Li Chen, Jian-Qing Mi

Annals of Translational Medicine

2022;

(12)

:722

| https://dx.doi.org/10.21037/atm-22-2533

(June 2022)

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Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

DeepSSR: a deep learning system for structured recognition of text images from unstructured paper-based medical reports

Hao Liu, Huijin Wang, Jieyun Bai, Yaosheng Lu, Shun Long

How long does it take to translate research findings into routine healthcare practice?—the case of biological drugs for rheumatoid arthritis in Brazil

Evandro de Oliveira Lupatini, Ivan Ricardo Zimmermann, Jorge Otávio Maia Barreto, Everton Nunes da Silva

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data

Chenyan Hong, Yiqiong Zheng, Rui Geng, Huayu Hu, Yuting Zhong, Qingyu Guan, Yanjun Zhang, Xiru Li

Association of PCSK9 levels and genetic polymorphisms with stroke recurrence and functional outcome after acute ischemic stroke

Weiqi Chen, Yicong Wang, Xia Meng, Yuesong Pan, Mengxing Wang, Hao Li, Yilong Wang, Yongjun Wang

Novel prognostic nomograms to assess survival in high-grade serous ovarian carcinoma after surgery and chemotherapy: a retrospective cohort study from SEER database

Wu Huang, Yiting Bao, Xukai Luo, Liangqing Yao, Lei Yuan

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury

Boyang Liu, Shengxiang Ao, Fang Tan, Wei Ma, Haoru Liu, Huaping Liang, Xia Yang, Xinjin Chi

Establishment of a novel risk score for in-hospital mortality in adult sepsis patients

Yan-Jun Zheng, Xiao-Juan Zhu, Yu-Wei Chen, Yu-Zhen Zheng, Yi Zhou, Wen-Jie Chen, Xiang-Tao Zheng, Ming Zhong, Zhi-Tao Yang, En-Qiang Mao, Er-Zhen Chen, Ying Chen

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Current usage and challenges of master protocols—based on survey results by ASA BIOP oncology methodology working group master protocol sub-team

Xiaoyun Li, Chengxing Lu, Kristine Broglio, Paul Bycott, Jie Chen, Qi Jiang, Jianchang Lin, Jingjing Ye, Jun Yin

Efficacy and adverse events of octreotide long-acting release in acromegaly: a real-world retrospective study

Zhe Zhao, Lian Duan, Daihui Gao, Yong Yao, Kan Deng, Bing Xing, Xinfeng Wang, Yan Tang, Huijuan Zhu, Xiaoguang Chen

Morphological characteristics of the subfoveal choroid and their association with visual acuity in postoperative patients with unilateral congenital cataracts

Yue Zhou, Jinghui Wang, Ling Jin, Wan Chen, Qiwei Wang, Hui Chen, Jingjing Chen, Zhouyue Li, Zhuoling Lin, Xiaoyan Li, Jing Li, Haotian Lin, Duoru Lin, Weirong Chen

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Prognostic value of CD247 in patients with head and neck squamous cell carcinoma: bioinformatic analysis of TCGA database

Peng Lin, Xiao-Li Hu, Yuan-Yuan Hu, Mai-Ying Liu, Qian-Yu Wang, Yan Ding, Jia-Cai Ye

Multimodal treatments of brain arteriovenous malformations: a comparison of microsurgical timings after endovascular embolization

Chaofan Zeng, Mingze Wang, Xiaowen Song, Chaoqi Zhang, Fa Lin, Qiheng He, Wuyang Yang, Yong Cao, Shuo Wang, Wenjun Tu, Jizong Zhao

Survival impact of additional induction chemotherapy in nasopharyngeal carcinoma with chronic hepatitis B infection: a retrospective, bi-center study

Haojiang Li, Mingyang Chen, Shuqi Li, Chao Luo, Xuemin Qiu, Guangying Ruan, Yanping Mao, Guoyi Zhang, Lizhi Liu

Ability of modern proximal tibial lateral plates to capture posterolateral tibial plateau fracture fragments

Lifeng Yan, Yu Zhan, Xuetao Xie, Yukai Wang, Yingqi Zhang, Congfeng Luo

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

Mutational characteristics of Chinese Han and ethnic minorities in southwestern China: a propensity score matched analysis

Yongchun Zhou, Xin Liu, Yinjin Guo, Zhuoying Li, Shunhui Zhu, Quan Li, Xiaoxiong Wang, Ruijiao Yang, Zhenghai Shen, Hongsheng Li, Yaxi Du, Luyao Ma, Shaocong Shen, Yunyi Lan, Yunchao Huang

Particle beam radiation therapy for head and neck rhabdomyosarcoma in adults

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxing Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

Drug discovery in spinal cord injury-induced osteoporosis: a text mining-based study

Chenfeng Wang, Yang Xu, Lin Han, Weiqing Wu, Xuhua Lu

Age, gender, geographic and clinical differences for gallstones in China: a nationwide study

Yang Song, Yuan Ma, Fu-Cun Xie, Cheng Jin, Xiao-Bo Yang, Xu Yang, Jun-Yu Long, Dong-Xu Wang, Xin-Ting Sang, Li-Ming Li, Hai-Tao Zhao, Yi Ning

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

A cross-sectional analysis of registered clinical trials on the use of particle beam radiation therapy in head and neck cancers

Wenna Zhang, Lin Kong, Jiade J. Lu

CBX4 contributes to radioresistance by regulating autophagic activity in esophageal squamous cell carcinoma

Hongcheng Zhu, Hui Chen, Guangzong Chen, Ming Liu, Li Chu, Yu Gu, Yun Chen, Chi Zhang, Qin Qin, Yanan Chen, Weiwei Chen, Jianhong Fan, Yongzhan Nie, Junqiang Chen, Shixiu Wu, Xinchen Sun, Weixin Zhao, Kuaile Zhao

Surface-based morphological patterns associated with neuropsychological performance, symptom severity, and treatment response in Parkinson’s disease

Jiajie Mo, Bowen Yang, Xiu Wang, Jianguo Zhang, Wenhan Hu, Chao Zhang, Kai Zhang

Salvianolic acid B alleviates neurological injury by upregulating stanniocalcin 1 expression

Shao-Jie Bi, Xin-Ying Dong, Ze-Ying Wang, Shan-Ji Fu, Chang-Ling Li, Zhao-Yang Wang, Fei Xie, Xue-Ying Chen, Hao Xu, Xiao-Jun Cai, Ming-Xiang Zhang

Review Article

Detection of anti-ganglioside antibodies in Guillain-Barré syndrome

Wenli Zhu, Ke Li, Tingting Cui, Yaping Yan

Uniportal pure robotic-assisted thoracic surgery—technical aspects, tips and tricks

Diego Gonzalez-Rivas, Veronica Manolache, Mugurel Liviu Bosinceanu, Javier Gallego-Poveda, Alejandro Garcia-Perez, Mercedes de la Torre, Akif Turna, Natalia Motas

Autoantibodies detection in anti-N-methyl-D-aspartate receptor encephalitis

Jiayu Li, Qi Wang, Honghao Wang

Challenges and opportunities in biomarker-driven trials: adaptive randomization

Yeonhee Park

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Evolution in anti-myelin oligodendrocyte glycoprotein antibody detection and its clinical significance: a narrative review

Xiaonan Zhong, Yina Wang, Wenjing Luo, Xiaoyu Ma, Xiaobo Sun, Boxiong Jiang, Wei Qiu

Novel clinical trial design and analytic methods to tackle challenges in therapeutic development in rare diseases

Yimei Li, Rima Izem

Focal therapy for prostate cancer: what is really needed to move from investigational to valid therapeutic alternative? A narrative review

Antony Pellegrino, Giuseppe O. Cirulli, Elio Mazzone, Francesco Barletta, Simone Scuderi, Mario de Angelis, Giuseppe Rosiello, Giorgio Gandaglia, Francesco Montorsi, Alberto Briganti, Armando Stabile

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Reflections from a NMOSD case with serum AQP4-Ab negativity but CSF positivity: narrative review of how to interpret AQP4-Ab test results

Qun Xue, Shugang Cao, Qianyun Rui

Autoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology

Weihua Zhang, Haitao Ren, Xiaotun Ren, Fang Fang, Hongzhi Guan

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Narrative review of autoantibodies in idiopathic inflammatory myopathies

Yilin Liu, Yiming Zheng, Hongjun Hao, Yun Yuan

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Focal cryotherapy for prostate cancer: a contemporary literature review

Srinath Kotamarti, Thomas J. Polascik

Sources of bias for single-arm phase II cancer clinical trials

Sin-Ho Jung

Exploring the therapeutic potential of Neem (Azadirachta Indica) for the treatment of prostate cancer: a literature review

Neelu Batra, Vigneshwari Easwar Kumar, Roshni Nambiar, Cristabelle De Souza, Ashley Yuen, Uyen Le, Rashmi Verma, Paramita M. Ghosh, Ruth L. Vinall

Editorial

Molecular pathological approach of uterine intravenous leiomyomatosis

Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi

A promising technique to improve and expand the practice of colposcopy to help the global fight against cervical cancer

Julio Cesar Teixeira, Diama Bhadra Vale

Letter to the Editor

The promises and challenges of pragmatism: lesson from of a recent clinical trial

Xiaoxi Yao, Peter A. Noseworthy

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

Sharp Minds in China-CAS and CAE: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in ATM

From bud to blossom: an overview on the publications from China’s two top academies Chinese Academy of Engineering and Chinese Academy of Sciences in Annals of Translational... More >>

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