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ATM Annual Report 2020

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2021. In 2020, ATM has made great progress under the join-efforts of experts worldwide.

- More than 1700 papers have been published in ATM in 2020.
- The retrieval of ATM in PubMed increased rapidly with a total of 3,452,243 times in 2020.
- The number of total citations by SCI journals has significantly increased to 21,008 until Dec. 2020
- The pageviews of ATM is increasing significantly, with a total of 2,230,740 hits in 2020.

Recent Developments in Cataract Surgery

We would like to share with the readers at large the contributions from invited authors who provided their unique and expert perspectives on the important and critical topics of this focus series titled “Recent Developments in Cataract Surgery”.

Infective Endocarditis in the 21st Century

Infective endocarditis (IE) is a consequence of the localized or systemic diffusion of pathogens, generally bacteria or fungi, in the heart. Complications of heart valve endocarditis (HVE) develops in approximately from 1% to 43% of patients. Development of any degree of valve regurgitation in patients with LV dysfunction have a higher mortality risk than those without valve regurgitation. This fact alone remains the primary driver for surgery in patients with HVE.

Current State of Intraoperative Imaging

This series of Annals of Translational Medicine presents a collection of review articles on the current state of intraoperative imaging in spinal surgery. The rates of spine surgery and spinal instrumentation have increased tremendously in the past two decades. This increase has been accompanied by technological innovations and advances that are expanding the horizon of spinal surgery and making these procedures increasingly feasible, safe and efficient for the management of a wide range of disorders.

Pain Therapy

In this series, recent developments on the assessment and pain management have been presented. The authors focused their attention on a wide field of applications: from new delivery systems for analgesics to pain assessment in clinical trials or interventional management of neuropathic pain.

Reviewer of the Month

Over the year, many ATM reviewers have made outstanding contributions to the peer review process. They demonstrated professional effort and enthusiasm in their reviews and provided comments that genuinely help the authors to enhance their work. We would like to highlight a few of our outstanding reviewers, with a brief interview of their thoughts and insights as a reviewer.

Ovarian Cancer: State of the Art and Perspectives of Clinical Research

Ovarian cancer is composed of three histological subtypes: epithelial (90%), germ cell (5%), and sex cord stromal cell (5%). Epithelial ovarian cancer (EOC) is the most lethal gynecological disorder due to lack of effective early detection strategies. The forthcoming special series focuses on several key elements that are essential for an understanding of this heterogeneous group of malignancies.

Lung Emphysema

Lung emphysema represents a major public health burden and still accounts for 5% of all deaths worldwide. Hence, it is essential to further understand this disease in order to develop effective diagnostic and therapeutic strategies. In our focused series, we highlight this disease from several aspects beginning with advances in imaging, going through developments of surgical and interventional therapies of lung volume reduction, perioperative anesthesiologic considerations, and giving an overview of the different phenotypes of chronic obstructive disease and correlations between lung cancer and lung emphysema, and concluding with lung transplantation for lung emphysema.

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Vol 9, No 4 (February, 2021)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Risk factors for mortality due to COVID-19 in intensive care units: a single-center study

Yu Chen, Zhengyin Liu, Xiaogang Li, Jing Zhao, Dong Wu, Meng Xiao, Dong Zhang, Peng Gao, Ran Tian, Jing Xie, Siyuan Fan, Binbin Li, Yingchun Xu, Yongzhe Li, Shuyang Zhang

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The risk of venous thromboembolism in cancer patients receiving chemotherapy: a meta-analysis with systematic review

Yun Bao, Xu Wan, Jie Fu, Bin Wu

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Compliance with the Surviving Sepsis Campaign guideline 1-hour bundle for septic shock in China in 2018

Lu Wang, Xudong Ma, Huaiwu He, Longxiang Su, Yanhong Guo, Guangliang Shan, Ye Wang, Xiang Zhou, Dawei Liu, Yun Long, China National Critical Care Quality Control Center Group

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Evaluation of the linear interpolation method in correcting the influence of slice thicknesses on radiomic feature values in solid pulmonary nodules: a prospective patient study

Shouxin Yang, Ning Wu, Li Zhang, Meng Li

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The clinical characteristics and prognosis of COVID-19 patients with comorbidities: a retrospective analysis of the infection peak in Wuhan

Guiying Dong, Zhe Du, Jihong Zhu, Yang Guo, Weibo Gao, Wei Guo, Tianbing Wang, Baoguo Jiang

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Development and validation of a predictive nomogram for postoperative osteonecrosis of the femoral head with cannulated screws fixation

Wanbo Zhu, Kai Xie, Xianzuo Zhang, Jiazhao Yang, Lei Xu, Junchen Zhu, Shiyuan Fang, Chen Zhu

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Urinary soluble CD90 predicts renal prognosis in patients with diabetic kidney disease

Liang Wu, Dong-Yuan Chang, Lu-Xia Zhang, Min Chen, Ming-Hui Zhao

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Transarterial chemoembolization (TACE) combined with apatinib versus TACE combined with sorafenib in advanced hepatocellular carcinoma patients: a multicenter retrospective study

Zhiyu Qiu, Lujun Shen, Yiquan Jiang, Jiliang Qiu, Zining Xu, Mengting Shi, Zhentao Yu, Yanping Ma, Wei He, Yun Zheng, Binkui Li, Guoying Wang, Yunfei Yuan

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Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry

Michael A. Cummings, Sung Jun Ma, Paul Van Der Sloot, Michael T. Milano, Deepinder P. Singh, Anurag K. Singh

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Hybrid coronary revascularization versus total arterial revascularization for the treatment of left main coronary artery disease

Pengxiong Zhu, Jiapei Qiu, Hong Xu, Jun Liu, Qiang Zhao

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Nomogram prediction for the overall survival and cancer-specific survival of patients diagnosed with Merkel cell carcinoma

Xufeng Yin, Huihui She, Lorna Martin Kasyanju Carrero, Weiwei Ma, Bingrong Zhou

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Development and validation of nomograms for predicting blood loss in placenta previa with placenta increta or percreta

Ruihui Lu, Ran Chu, Na Gao, Guiyang Li, Haiyang Tang, Xinxin Zhou, Xiangxin Lan, Shuyi Li, Xi Zhang, Yintao Xu, Yuyan Ma

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Contrast-enhanced computed tomography prior to percutaneous transthoracic needle biopsy reduces the incidence of hemorrhage

Huan Hu, Chuling Li, Tangfeng Lv, Huijuan Li, Yangbo Hu, Qin Shen, Mari Mino-Kenudson, Luca Bertolaccini, Gaetano Rocco, Pavlos Zarogoulidis, Fang Zhang, Dang Lin, Hongbing Liu, Yong Song, written on behalf of AME Pulmonary Disease Collaborative Group

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Increased portal vein diameter is predictive of portal vein thrombosis development in patients with liver cirrhosis

Gang Dong, Xiao-Quan Huang, Yu-Li Zhu, Hong Ding, Feng Li, Shi-Yao Chen

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Efficacy and safety of immune checkpoint inhibitors in gastric cancer: a network meta-analysis of well-designed randomized controlled trials

Siwei Pan, Kai Li, Baojun Huang, Jinyu Huang, Huimian Xu, Zhi Zhu

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Automatic segmentation of pulmonary lobes on low-dose computed tomography using deep learning

Zewei Zhang, Jialiang Ren, Xiuli Tao, Wei Tang, Shijun Zhao, Lina Zhou, Yao Huang, Jianwei Wang, Ning Wu

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Effects of earthworm extract on the lipid profile and fatty liver induced by a high-fat diet in guinea pigs

Zhenhan Deng, Shanshan Gao, Yunfei An, Yong Huang, Haifeng Liu, Weimin Zhu, Wei Lu, Miao He, Wenqing Xie, Dengjie Yu, Yusheng Li

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Development and validation of a novel nomogram to predict cancer-specific survival in patients with uterine cervical adenocarcinoma

Xiao Ni, Xiaoling Ma, Jiangnan Qiu, Shulin Zhou, Wenjun Cheng, Chengyan Luo

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Prognostic value of free triiodothyronine and N-terminal pro-B-type natriuretic peptide for patients with acute myocardial infarction undergoing percutaneous coronary intervention: a prospective cohort study

Kaihao Wang, Wenyao Wang, Kuo Zhang, Jun Gao, Yupeng Liu, Jilin Zheng, Ping Li, Yida Tang

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Application of deep learning to predict underestimation in ductal carcinoma in situ of the breast with ultrasound

Lang Qian, Zhikun Lv, Kai Zhang, Kun Wang, Qian Zhu, Shichong Zhou, Cai Chang, Jie Tian

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Accurate nomograms with excellent clinical value for locally advanced rectal cancer

Yuqiang Li, Da Liu, Lilan Zhao, Cenap Güngör, Xiangping Song, Dan Wang, Wenxue Liu, Fengbo Tan

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Lateralizing the affected side of hippocampal sclerosis with quantitative high angular resolution diffusion scalars: a preliminary approach validated by diffusion spectrum imaging

Yi-He Wang, Zhen-Ming Wang, Peng-Hu Wei, Chao Lu, Xiao-Tong Fan, Lian-Kun Ren, Yong-Zhi Shan, Jie Lu, Guo-Guang Zhao

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Multi-modal magnetic resonance imaging-based grading analysis for gliomas by integrating radiomics and deep features

Zhenyuan Ning, Jiaxiu Luo, Qing Xiao, Longmei Cai, Yuting Chen, Xiaohui Yu, Jian Wang, Yu Zhang

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Role of thoracic radiotherapy in extensive stage small cell lung cancer: a systemic review and meta-analysis

Ao-Mei Li, Han Zhou, Yang-Yang Xu, Xiao-Qin Ji, Tian-Cong Wu, Xi Yuan, Chang-Chen Jiang, Xi-Xu Zhu, Ping Zhan, Ze-Tian Shen

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Comparison of three lymph node staging methods for predicting outcome in breast cancer patients with mastectomy

Meng-Shen Wang, Mo-Zhi Wang, Zhenning Wang, Yongxi Song, Peng Gao, Pengliang Wang, Chong Wang, Xueting Yu, Fengheng Wei, Jingyi Guo, Yingying Xu

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A predictor of pathological complete response to neoadjuvant chemotherapy in triple-negative breast cancer patients with the DNA repair genes

Liang Huang, Guan-Tian Lang, Qi Liu, Jin-Xiu Shi, Zhi-Ming Shao, A-Yong Cao

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Injury pattern simulation and mapping of complex tibial plateau fractures that involve the posterior plateau with three-dimensional computed tomography

Shuo Pan, A-Qin Peng, Ya-Ning Hu, Shuai Wang, Yan-Long Zhang, Yong Wang

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Surgical treatment of joint burn scar contracture: a 10-year single-center experience with long-term outcome evaluation

Zhouji Ma, Ran Mo, Chen Chen, Xueyong Meng, Qian Tan

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Vimentin regulation of autophagy activation in lung fibroblasts in response to lipopolysaccharide exposure in vitro

Pan Pan, Longxiang Su, Xiaoting Wang, Wenzhao Chai, Dawei Liu, Licheng Song, Lixin Xie

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A cohort study of hepatectomy-related complications and prediction model for postoperative liver failure after major liver resection in 1,441 patients without obstructive jaundice

Bin Li, Yingyi Qin, Zhiquan Qiu, Jun Ji, Xiaoqing Jiang

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An analytical study of drug utilization, disease progression, and adverse events among 165 COVID-19 patients

Feng Sun, Hao Kou, Shengfeng Wang, Yun Lu, Houyu Zhao, Wenjing Li, Qingxin Zhou, Qiaoli Jiang, Yinchu Cheng, Kun Yang, Lin Zhuo, Yang Xu, Dongfang Wu, Siyan Zhan, Hong Cheng

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CT-US fusion imaging increases the feasibility of early ultrasound-guided percutaneous intervention of local drug therapy in pancreatic contusion and laceration

Cong Feng, Libo Wang, Sai Huang, Qinrui Xing, Xuan Zhou, Ning Xing, Faqin Lv, Tanshi Li

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A novel dynamic random-dot stereopsis assessment to measure stereopsis in intermittent exotropia

Jing Zhong, Daming Deng, Zidong Chen, Jinrong Li, Junpeng Yuan, Lei Feng, Minbin Yu

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The effects of heatwaves and cold spells on patients admitted with acute ischemic stroke

Xuemei Qi, Zhongyan Wang, Xiaoshuang Xia, Juanjuan Xue, Yumeng Gu, Suqin Han, Qing Yao, Ziying Cai, Xiaojia Wang, Lin Wang, Sean X. Leng, Xin Li

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Primary tumor immune score fails to predict the prognosis of colorectal cancer liver metastases after hepatectomy in Chinese populations

Hao-Cheng Lin, Qiong Shao, Jie-Ying Liang, Yun Wang, Hui-Zhong Zhang, Yun-Fei Yuan, Bin-Kui Li, Xiao-Jun Wu, Gong Chen, Pei-Rong Ding, Zhen-Hai Lu, Zhi-Zhong Pan, De-Shen Wang, Miao-Zhen Qiu, Zhi-Qiang Wang, Feng-Hua Wang, Rui-Hua Xu, Yu-Hong Li

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Duet laparoscopic repair with knotless barbed sutures for treatment of perforated peptic ulcer: reality in general surgery with lacking of manpower

Dong-Wook Kim, Sanghyun Song, Ye Seob Jee

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Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway

Bin Qi, Xiaowen Zhang, Hang Yu, Yandong Bao, Nan Wu, Dalin Jia

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Regulation of smooth muscle contractility by the epithelium in rat tracheas: role of prostaglandin E2 induced by the neurotransmitter acetylcholine

Lei Zhao, Yu-Ting Liang, Dong-Bo Tian, Rui-Gang Zhang, Jiehong Huang, Yun-Xin Zhu, Wen-Liang Zhou, Yi-Lin Zhang

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Incident cerebral microbleeds and hypertension defined by the 2017 ACC/AHA Guidelines

Yiwei Xia, Yi Wang, Lumeng Yang, Yiqing Wang, Xiaoniu Liang, Qianhua Zhao, Jianjun Wu, Shuguang Chu, Zonghui Liang, Hansheng Ding, Ding Ding, Xin Cheng, Qiang Dong

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The associations of population mobility in HIV disease severity and mortality rate in China

Wangting Li, Xiaoli Wang, Yahan Yang, Lanqin Zhao, Duoru Lin, Jinghui Wang, Yi Zhu, Chuan Chen, Zhenzhen Liu, Xiaohang Wu, Xiayin Zhang, Ruixin Wang, Ruiyang Li, Daniel Shu Wei Ting, Wenyong Huang, Haotian Lin

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Bone metabolic biomarker-based diagnosis of type 2 diabetes osteoporosis by support vector machine

Chuan Wang, Taomin Zhang, Peng Wang, Xuan Liu, Liming Zheng, Lei Miao, Deyu Zhou, Yibo Zhang, Yezi Hu, Han Yin, Qing Jiang, Hui Jin, Jianfei Sun

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Development and validation of an autophagy-related prognostic signature in esophageal cancer

Hailei Du, Shanshan Xie, Wei Guo, Jiaming Che, Lianggang Zhu, Junbiao Hang, Hecheng Li

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A novel prophylactic Chinese parachute ankle brace

Xi Zhou, Di Wu, Xiangdong Wu, Zhengyao Li, Bin Yan, Leilei Liang, Yu He, Yong Liu

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Application of an optimized pharyngeal swab-assisted device in pharyngeal sampling for COVID-19 patients

Jie Jia, Sun-Ting Fang, Xiao-Bo Feng, Wei Tong, Hong-Tao Tian, Jing Tang

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Safety and feasibility of single-incision radical vulvectomy: a novel approach for the treatment of vulvar cancer

Liqing He, Gaowen Chen, Xiaoxuan Li, Youhong Zheng, Mengting Wu, Huiyan Wang, Xiaohong Liu, Wuqi He, Xiaodan Liu, Shaozhuo Huang, Fan Lin, Weixin Liao, Ying Ma, Yifeng Wang

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SOX2 amplification and chromosome 3 gain significantly impact prognosis in esophageal squamous cell carcinoma

Xin Wang, Xiaowen Ge, Haixing Wang, Jie Huang, Qi Song, Chen Xu, Zhengzeng Jiang, Jieakesu Su, Hao Wang, Lijie Tan, Dongxian Jiang, Yingyong Hou

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Comparing long-term outcomes between endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) for type II esophagogastric junction neoplasm

Yong Liu, Shun He, Yueming Zhang, Lizhou Dou, Xiao Liu, Xinying Yu, Ning Lu, Liyan Xue, Guiqi Wang

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Development and validation of a risk stratification model for predicting the mortality of acute kidney injury in critical care patients

Haofan Huang, Yong Liu, Ming Wu, Yi Gao, Xiaxia Yu

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Accuracy of intraocular lens calculation formulas for eyes with insufficient capsular support

Zhouyue Li, Zhangkai Lian, Charlotte Aimee Young, Jing Zhao, Guangming Jin, Danying Zheng

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Sarcopenia is poor risk for unfavorable short- and long-term outcomes in stage I non-small cell lung cancer

Yusuke Takahashi, Shigeki Suzuki, Kenichi Hamada, Takeo Nakada, Yuko Oya, Noriaki Sakakura, Hirokazu Matsushita, Hiroaki Kuroda

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Population attributable risk of excess weight, abdominal obesity and physical inactivity for type 2 diabetes in Chinese men and women

Guo-Shan Feng, Hong-Lan Li, Qiu-Ming Shen, Zhuo-Ying Li, Xiao-Wei Ji, Yong-Bing Xiang

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Association between glucose fluctuation during 2-hour oral glucose tolerance test, inflammation and oxidative stress markers, and β-cell function in a Chinese population with normal glucose tolerance

Chifa Ma, Yiwen Liu, Shuli He, Jingbo Zeng, Pingping Li, Chunxiao Ma, Fan Ping, Huabing Zhang, Lingling Xu, Wei Li, Yuxiu Li

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B7-H6 is a new potential biomarker and therapeutic target of T-lymphoblastic lymphoma

Lei Yuan, Lu Sun, Siyuan Yang, Xin Chen, Jing Wang, Hongmei Jing, Yu Zhao, Xiaoyan Ke

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The effect of primary site, functional status and treatment modality on survival in gastroenteropancreatic neuroendocrine neoplasms with synchronous liver metastasis: a US population-based study

Ning Pu, Joseph R. Habib, Michael Bejjani, Hanlin Yin, Minako Nagai, Jianan Chen, Benedict Kinny-Köster, Qiangda Chen, Jicheng Zhang, Jun Yu, Wenchuan Wu, Wenhui Lou

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A systematic analysis of a potential metabolism-related prognostic signature for breast cancer patients

Shibo Yu, Xiaowen Wang, Lizhe Zhu, Peiling Xie, Yudong Zhou, Siyuan Jiang, Heyan Chen, Xiaoqin Liao, Shengyu Pu, Zhenzhen Lei, Bin Wang, Yu Ren

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Osteogenic differentiation characteristics of hip joint capsule fibroblasts obtained from patients with ankylosing spondylitis

Nan Jiang, Hong-Xiao Liu, Hui-Ying Liang, Xing-Hua Feng, Ben-Yong Liu, Ying-Yan Zhou

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Huperzine A lowers intraocular pressure via the M3 mAChR and provides retinal neuroprotection via the M1 mAChR: a promising agent for the treatment of glaucoma

Ping Yu, Wen-Pei Dong, Ya-Bin Tang, Hong-Zhuan Chen, Yong-Yao Cui, Xiao-Lan Bian

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Fracture mapping of complex intra-articular calcaneal fractures

Ming Ni, Miko Lin Lv, Wanju Sun, Yingqi Zhang, Jiong Mei, Duo Wai-Chi Wong, Haowei Zhang, Yongwei Jia, Ming Zhang

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Heart rate fluctuation predicts mortality in critically ill patients in the intensive care unit: a retrospective cohort study

Qi Guo, Zhanchao Xiao, Maohuan Lin, Guiyi Yuan, Qiong Qiu, Ying Yang, Huiying Zhao, Yuling Zhang, Shuxian Zhou, Jingfeng Wang

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Peri-implant tissue alteration around tissue-level and bone-level implants in fresh extraction sockets: a histomorphometric study in dogs

Chunan Zhang, Xu Zhao, Shichong Qiao, Xiaomeng Zhang, Hongchang Lai, Yingxin Gu

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The clinical value of bedside ultrasound in predicting the severity of coronavirus disease-19 (COVID-19)

Jianzhong Xian, Xiaofeng Pei, Wuzhu Lu, Haihong Zhong, Yuhong Lin, Hongjun Jin, Zhongzhen Su

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Predictors and risk factors for intestinal necrosis in patients with mesenteric ischemia

Hongwei Zhao, Yiting Meng, Peng Zhang, Qian Zhang, Feng Wang, Yuanxin Li

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Docetaxel maintenance therapy versus best supportive care after first-line chemotherapy with different dose docetaxel plus cisplatin for advanced non-small cell lung cancer (TFINE study, CTONG-0904): an open-label, randomized, phase III trial

Li Zhang, Shun Lu, Ying Cheng, Zhihuang Hu, Yi-Long Wu, Zhiwei Chen, Gongyan Chen, Xiaoqing Liu, Jinji Yang, Li Zhang, Jia Chen, Meijuan Huang, Min Tao, Gang Cheng, Cheng Huang, Caicun Zhou, Weimin Zhang, Hong Zhao, Yuping Sun

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Real-world experience with pembrolizumab in patients with advanced soft tissue sarcoma

Jiayong Liu, Zhengfu Fan, Chujie Bai, Shu Li, Ruifeng Xue, Tian Gao, Lu Zhang, Zhichao Tan, Zhiwei Fang

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Aerobic exercise improves cardiac function in rats with chronic heart failure through inhibition of the long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)

Ling Hu, Ya-Nan Xu, Qian Wang, Mei-Jie Liu, Ping Zhang, Lan-Ting Zhao, Fang Liu, Dong-Yan Zhao, He-Nan Pei, Xing-Bao Yao, Hua-Gang Hu

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Transsacrococcygeal approach in rectal gastrointestinal stromal tumour resection: 10-year experience at a single centre

Xiusen Qin, Chuangkun Li, Zifeng Yang, Wentai Guo, Huili Guo, Chun Chen, Rongkang Huang, Di Zhang, Huaiming Wang, Hui Wang

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A nomogram to predict the incidence of permanent stoma in elderly patients with rectal cancer

Chuangkun Li, Xiusen Qin, Zifeng Yang, Wentai Guo, Rongkang Huang, Huaiming Wang, Hui Wang

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Value of serum and follicular fluid sirtuin (SIRT)1 and SIRT2 protein levels in predicting the outcome of assisted reproduction

Ling-Nv Yao, Tian-Fang Zhang, Wen-Qin Lin, Nan Jiang, Hai-Feng Cao, Hong Li, Jian-Hua Qian

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The effects of three different contrast agents (Gd-BOPTA, Gd-DTPA, and Gd-DOTA) on brachial plexus magnetic resonance imaging

Xiaojing Zhang, Wensheng Wang, Tiefang Liu, Yeqing Qi, Lin Ma

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Risk factors related to the loss of reduction after acromioclavicular joint dislocation treated with the EndoButton device

Kai Chen, Bin Xu, Yang-Jun Lao, Yang Yang

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Study on the differential proteomics of rat hippocampal mitochondria during deep hypothermic circulatory arrest

Yongjun Gao, Xiuli Han, Liang Wei, Yong Yuan, Chengbin Zhao, Ming Zhang, Zheng Wang, Xuhui Li, Wei Xu

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Identification of drug compounds for keloids and hypertrophic scars: drug discovery based on text mining and DeepPurpose

Yuyan Pan, Zhiwei Chen, Fazhi Qi, Jiaqi Liu

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Kindlin-2 regulates the differentiation of 3T3-L1 preadipocytes: implications for wound healing

Yuyan Pan, Qiang Wang, Wenjie Luan, Yuedong Shi, Jiaqi Liu, Fazhi Qi

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Functional plasticity abnormalities over the lifespan of first-episode patients with major depressive disorder: a resting state fMRI study

Li Yang, An-Hai Wei, Tan-Te Ouyang, Zhen-Zhen Cao, Ao-Wen Duan, He-Hua Zhang

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Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14)-mediated Nrf2 and nuclear factor-κB (NF-κB) pathways

Jun Xu, Liang Ma, Ping Fu

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The predictive value of minute ventilation versus carbon dioxide production in pulmonary hypertension associated with left heart disease

Xiujun Zhong, Jie Tang, Rong Jiang, Ping Yuan, Qinhua Zhao, Sugang Gong, Jinming Liu, Lan Wang

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Short-term outcomes of laparoscopic versus open proximal gastrectomy with double-tract reconstruction for Siewert type II and III adenocarcinoma of the esophagogastric junction: a retrospective observational study of consecutive patients

Fei Ma, Weifeng Wang, Dandan Guo, Yonglei Zhang, Liangqun Peng, Qi Ma, Sheqing Ji, Junhui Chai, Yawei Hua, Xiaobing Chen, Hui Wang, Shuning Xu, Qian Li, Suxia Luo, Hiroharu Yamashita, Kheng Tian Lim, Tian Li, Bin Zhang

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Correlation between serum cartilage oligomeric matrix protein and major adverse cardiovascular events within 30 days in patients with acute coronary syndrome

Hao Chen, Jing Wang, Ling Xie, Ya-Li Shen, Hui-Min Wang, Kou-Long Zheng, Qing Zhang

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A thermochromic tissue-mimicking phantom model for verification of ablation plans in thermal ablation

Yan Zhou, Lin Zhao, Xinyu Zhong, Jianmin Ding, Hongyu Zhou, Fengmei Wang, Xiang Jing

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Chemoprotective effect of atorvastatin against benzo(a)pyrene-induced lung cancer via the inhibition of oxidative stress and inflammatory parameters

Xusheng Du, Dongfan Li, Guanjie Wang, Yali Fan, Namiao Li, Lili Chai, Guangshun Li, Jianying Li

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A new classification of descending necrotizing mediastinitis and surgical strategies

Xin Guan, Xiang Liang, Xi Liang, Feng Wang, Wentao Qian, Weijie Zhang

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Adult pulmonary Langerhans cell histiocytosis might consist of two distinct groups: isolated form and extrapulmonary recidivism type

Jing Wang, Liwu Xie, Yuchun Miao, Xiaoyu Liu, Yuan Tang, Yanfeng Xi, Jiang Chang, Yueqin Wu, Lili Jiang

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Aberrant lactate dehydrogenase A signaling contributes metabolic signatures in pancreatic cancer

Wenna Jiang, Lu Qiao, Duo Zuo, Di Qin, Jiawei Xiao, Haohua An, Yanhui Wang, Xinwei Zhang, Yu Jin, Li Ren

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Review Article

Long non-coding RNA signatures as predictors of prognosis in thyroid cancer: a narrative review

Hongyuan Zhao, Cristabelle De Souza, Vigneshwari Easwar Kumar, Roshni Nambiar, Dake Hao, Xiaofeng Zhu, Yi Luo, Shengshan Liu, Lingyun Zhang, Jingqiang Zhu

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Case Report

Treatment of common iliac vein aneurysms: case report and literature review

Fei Li, Ruili Zhang, Jiangping Chen, Xiang Wang, Haiwei Chu, Wenjun Zhao

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Editorial

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

Hyperthermic intrathoracic chemotherapy (HITHOC) should be included in the guidelines for malignant pleural mesothelioma

Marcello Migliore, Michael Ried, Laureano Molins, Marco Lucchi, Marcello Ambrogi, Tamas F. Molnar, Hans-Stefan Hofmann

Editorial for “Heart Failure Update and Advances in 2021”

Debabrata Mukherjee, Jose B. Cruz Rodriguez

Esophageal surgery in the 21^st century

Ory Wiesel

Unresolved basic issues in hepatology

Ralf Weiskirchen, Wolfgang Stremmel

Why rheumatologic skin disease?

Richard D. Sontheimer, M. Kari Connolly, David F. Fiorentino, Victoria P. Werth

Artificial intelligence in molecular imaging: at the crossroads of revolutions in medical diagnosis

Steven P. Rowe

Editorial Commentary

Postoperative adjuvant EGFR-TKIs for resected EGFR-mutant NSCLC—opportunities and obstacles

Brielle A. Parris, Steven Leong, Henry Marshall, Ian A. Yang, Rayleen V. Bowman, Kwun M. Fong

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Prognostic values of treatment modalities on head and neck mucosal melanomas in elderly patients: a population-based analysis

Enni Chen, Jiawei Wu, Zhiqiao Liu, Shanshan Yang, Jiali Wu, Puyun Ouyang, Fangyun Xie

A novel metabolic gene signature-based nomogram to predict overall survival in breast cancer

Xi Sun, Zhi-Rui Zhou, Yan Fang, Shuning Ding, Shuangshuang Lu, Zheng Wang, Hui Wang, Xiaosong Chen, Kunwei Shen

The Anaesthetic Biobank of Cerebrospinal fluid: a unique repository for neuroscientific biomarker research

Celien Tigchelaar, Sawal D. Atmosoerodjo, Martijn van Faassen, Klaas J. Wardenaar, Peter P. De Deyn, Robert A. Schoevers, Ido P. Kema, Anthony R. Absalom

Mechanism of scar formation following Roux-en-Y choledochojejunostomy in a novel rat model of obstructive jaundice

Shao-Cheng Lyu, Jing Wang, Lin Zhou, Ji-Qiao Zhu, Fei Pan, Tao Jiang, Ren Lang, Qiang He

A simple lectin-based biochip might display the potential clinical value of glycomics in patients with spontaneous intracerebral hemorrhage

Lei Ye, Yong-Sheng Fang, Xiao-Xue Li, Yi Gao, Sheng-Sheng Liu, Qiang Chen, Qiang Wu, Hong-Wei Cheng, Wei-Dong Du

Mass SARS-CoV-2 molecular and serological screening of medical staff and patients in Hangzhou, China: no evidence of RNA detection, low seroprevalence, and limited exposure risk in the hospital setting

Jun Huang, Lu Zhang, Shengjun Wu, Jie Lu, Fengying Li, Yulan Cheng, Qi Zhang, Guiling Li, Haitao Yu, Zhian Le, Xiaowen He, Yanjun Ding, Daniel Candotti, Xinyou Xie, Jun Zhang

Nomogram for predicting the survival rate of primary pulmonary mucoepidermoid carcinoma patients: a retrospective study based on SEER database

Guo Lin, Hengrui Liang, Wei Wang, Jun Liu, Jianfu Li, Wenhua Liang, Jianxing He

The clinicopathological features of drug-induced acute kidney injury—a single-center retrospective analysis

Yu Cui, Yi Yang, Wenhua Lei, Xiabing Lang, Jianghua Chen

Transient perioperative inflammation following lung transplantation and major thoracic surgery with elective extracorporeal support: a prospective observational study

Cecilia Veraar, Stefan Schwarz, Jürgen Thanner, Martin Direder, Panja M. Boehm, Leopold Harnoncourt, Joachim Ortmayr, Clarence Veraar, Julia Mascherbauer, Walter Klepetko, Martin Dworschak, Hendrik J. Ankersmit, Bernhard Moser

countfitteR: efficient selection of count distributions to assess DNA damage

Jarosław Chilimoniuk, Alicja Gosiewska, Jadwiga Słowik, Romano Weiss, P. Markus Deckert, Stefan Rödiger, Michał Burdukiewicz

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A. Nolta, Susanna S. Park

Variables in the Danish Hernia Databases: inguinal and ventral

Jacob Rosenberg, Hans Friis-Andersen, Lars Nannestad Jørgensen, Kristoffer Andresen

Association of genetic variants of TMEM135 and PEX5 in the peroxisome pathway with cutaneous melanoma-specific survival

Haijiao Wang, Hongliang Liu, Wei Dai, Sheng Luo, Christopher I. Amos, Jeffrey E. Lee, Xin Li, Ying Yue, Hongmei Nan, Qingyi Wei

Advances in the surgical outcomes of 300 cases of pure laparoscopic living donor right hemihepatectomy divided into three periods of 100 cases: a single-centre case series

Eui Soo Han, Kyung-Suk Suh, Kwang-Woong Lee, Nam-Joon Yi, Suk Kyun Hong, Jeong-Moo Lee, Kwang Pyo Hong, Ming Yuan Tan

Macrophage regulator of G-protein signaling 12 contributes to inflammatory pain hypersensitivity

Gongsheng Yuan, Shuting Yang, Mayank Gautam, Wenqin Luo, Shuying Yang

Three-dimensional ophthalmic artery model reconstruction and assessment captured by computed tomographic angiography in non-arteritic anterior ischemic optic neuropathy patients

Jia-Lin Wang, Dong-Hui Wu, Hong-Yang Li, Yan-Ling Wang

Non-intubated video-assisted thoracic surgery for subxiphoid anterior mediastinal tumor resection

Yong Mao, Hengrui Liang, Shiqi Deng, Yuan Qiu, Yanran Zhou, Hanzhang Chen, Long Jiang, Jianxing He

A predictive model for postthrombotic syndrome in proximal deep vein thrombosis patients

Peng Qiu, Junchao Liu, Fuzhen Wan, Yuqian Chen, Kaichuang Ye, Jinbao Qin, Qun Huang, Xinwu Lu

Decreased serum fibroblast growth factor 19 level is a risk factor for type 1 diabetes

Jingyi Hu, Yingxin Tang, Hui Liu, Yanhua Li, Xia Li, Gan Huang, Yang Xiao, Zhiguang Zhou

Carbon-ion radiotherapy boost with standard dose proton radiation for incomplete-resected high-grade glioma: a phase 1 study

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Qingting Huang, Lin Kong, Jiade J. Lu

A nomogram to predict survival in patients with acute-on-chronic hepatitis B liver failure after liver transplantation

Liang Chen, Jiebin Zhang, Tongyu Lu, Jianye Cai, Jun Zheng, Jia Yao, Shuhong Yi, Hua Li, Guihua Chen, Hui Zhao, Yingcai Zhang, Yang Yang

Risk stratification and corresponding postoperative treatment strategies for occult contralateral lymph node metastasis in pyriform sinus squamous cell carcinoma patients with ipsilateral node-positive necks

Yu Heng, Xiaoke Zhu, Liang Zhou, Ming Zhang, Kenan Li, Lei Tao

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

The diagnostic performance of the Gynecologic Imaging Reporting and Data System (GI-RADS) in adnexal masses

Wen Guo, Xiuhe Zou, Hanyue Xu, Tao Zhang, Yunuo Zhao, Lu Gao, Wenyue Duan, Xuelei Ma, Ling Zhang

Protective effects and molecular mechanisms of Achyranthes bidentata polypeptide k on Schwann cells

Meiyuan Li, Ye Zhu, Leili Tang, Hua Xu, Jingfei Zhong, Wenqiang Peng, Ying Yuan, Xiaosong Gu, Hongkui Wang

Umbilical cord mesenchymal stem cells enhance the therapeutic effect of imipenem by regulating myeloid-derived suppressor cells in septic mice

Xianming Long, Xiaojing Li, Tao Li, Qing Yan, Lihui Wen, Xixi Yang, Hui Li, Lingyun Sun

A computed tomography (CT)-derived radiomics approach for predicting primary co-mutations involving TP53 and epidermal growth factor receptor (EGFR) in patients with advanced lung adenocarcinomas (LUAD)

Ying Zhu, Yu-Biao Guo, Di Xu, Jing Zhang, Zhen-Guo Liu, Xi Wu, Xiao-Yu Yang, Dan-Dan Chang, Min Xu, Jing Yan, Zun-Fu Ke, Shi-Ting Feng, Yang-Li Liu

Matched pair analysis to evaluate weight loss during radiation therapy for head and neck cancer as a prognostic factor for survival

Hye Ri Han, Gregory M. Hermann, Sung Jun Ma, Austin J. Iovoli, Kimberly E. Wooten, Hassan Arshad, Vishal Gupta, Ryan P. McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Jon M. Chan, Mary E. Platek, Andrew D. Ray, Fangyi Gu, Wesley L. Hicks Jr, Anurag K. Singh

Genetically predicted bipolar disorder is causally associated with an increased risk of breast cancer: a two-sample Mendelian randomization analysis

Haoxin Peng, Xiangrong Wu, Fan Ge, Zhenyu Huo, Yaokai Wen, Caichen Li, Jinsheng Lin, Hengrui Liang, Ran Zhong, Jun Liu, Runchen Wang, Jianxing He, Wenhua Liang

A four-year observation of corneal densitometry after implantable collamer lens V4c implantation

Jing Zhao, Wen Yang, Jiao Zhao, Yang Shen, Ling Sun, Tian Han, Xiaoying Wang, Peijun Yao, Xingtao Zhou

Matched pair analysis for comparison of survival outcome of alternative regimens to standard three-weekly cisplatin-based concurrent chemoradiation of head and neck cancer

Hye Ri Han, Sung Jun Ma, Gregory M. Hermann, Austin J. Iovoli, Kimberly E. Wooten, Hassan Arshad, Vishal Gupta, Ryan P. McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Jon M. Chan, Mary E. Platek, Andrew D. Ray, Fangyi Gu, Wesley L. Hicks Jr, Anurag K. Singh

Electrophysiological mapping and assessment of facial nerve functioning during acoustic neuroma operations

Xiaoyu Li, Yuhai Bao, Jiantao Liang, Ge Chen, Hongchuan Guo, Mingchu Li

Progesterone protocol versus gonadotropin-releasing hormone antagonist protocol in women with polycystic ovarian syndrome undergoing in vitro fertilization treatments with frozen-thawed embryo transfer: a prospective randomized controlled trial

Xiuxian Zhu, Hongjuan Ye, Jing Ye, Yonglun Fu

Inhibition of bone morphogenetic protein receptor 2 suppresses pancreatic ductal adenocarcinoma growth by regulating GRB2/ PI3K/AKT axis

Yazhou Wang, Huahu Guo, Zhengkui Zhang, Qi Wang, Xiaodong Tian, Yinmo Yang

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Associations of hand washing frequency with the incidence of illness: a systematic review and meta-analysis

Yangqin Xun, Qingxia Shi, Nan Yang, Nan Yang, Yan Li, Wenwen Si, Qianling Shi, Zijun Wang, Xia Liu, Xuan Yu, Qi Zhou, Minyan Yang, Yaolong Chen

Lactobacillus delbrueckii alleviates depression-like behavior through inhibiting toll-like receptor 4 (TLR4) signaling in mice

Xiangjie Qiu, Guojun Wu, Lili Wang, Yurong Tan, Zhi Song

Hot spots and trends in knee revision research since the 21st century: a bibliometric analysis

Kelei Zhai, Weifeng Ma, Tao Huang

A potentially effective drug for patients with recurrent glioma: sermorelin

Yuanhao Chang, Ruoyu Huang, You Zhai, Lijie Huang, Yuemei Feng, Di Wang, Ruichao Chai, Wei Zhang, Huimin Hu

A novel and efficient surgical knotting technique for high-tension closures

Yongyun Chang, Degang Yu, Liao Wang, Jingwei Zhang, Mengning Yan, Huiwu Li, Yuanqing Mao, Zanjing Zhai

Hemoglobin A1c modifies the association between triglyceride and time in hypoglycemia determined by flash glucose monitoring in adults with type 1 diabetes: implications for individualized therapy and decision-making

Yiwen Liu, Jie Yu, Chifa Ma, Shuli He, Fan Ping, Huabing Zhang, Wei Li, Lingling Xu, Xinhua Xiao, Yuxiu Li

The prognostic significance of tumor deposits in patients with head and neck squamous cell carcinomas

Shuting Yu, Yingying Zhu, Xiaohua Shi, Wenwen Diao, Xiaoli Zhu, Zhiqiang Gao, Xingming Chen

Development of a normal tissue complication probability (NTCP) model using an artificial neural network for radiation-induced necrosis after carbon ion re-irradiation in locally recurrent nasopharyngeal carcinoma

Tian Wang, Jiyi Hu, Qingting Huang, Weiwei Wang, Xiyu Zhang, Liwen Zhang, Xiaodong Wu, Lin Kong, Jiade Jay Lu

The predictive value of microRNAs for pathological response after neoadjuvant treatment in esophageal squamous cell carcinoma: a systematic review

Dong Lin, Xiaosang Chen, Lijie Tan

The ‘Hybrid method’ for the treatment of congenital clubfoot

Federico Canavese, Mounira Mansour, Léa Souchon, Antoine Samba, Alain Dimeglio

In-hospital mortality of liver transplantation and risk factors: a single-center experience

Xing-Mao Zhang, Hua Fan, Qiao Wu, Xin-Xue Zhang, Ren Lang, Qiang He

Supercapsular percutaneously-assisted total hip (SuperPath) versus mini-incision posterolateral total hip arthroplasty for hip osteoarthritis: a prospective randomized controlled trial

Weikun Meng, Liang Gao, Zhong Huang, Haoyang Wang, Duan Wang, Zeyu Luo, Yang Bai, Guanglin Wang, Zongke Zhou

Assessing the risk of rapid fibroid growth in patients with asymptomatic solitary uterine myoma using a multivariate prediction model

Qingxiu Li, Jiehui Zhong, Dongyi Yi, Genqiang Deng, Zezhen Liu, Wei Wang

Inhibitory Smads suppress pancreatic stellate cell activation through negative feedback in chronic pancreatitis

Hao Lin, Beibei Dong, Liang Qi, Yingxiang Wei, Yusha Zhang, Xiaotian Cai, Qi Zhang, Jia Li, Ling Li

Which is the most effective one in knee osteoarthritis treatment from mesenchymal stem cells obtained from different sources? —A systematic review with conventional and network meta-analyses of randomized controlled trials

Zhen-Jie Wei, Qian-Qian Wang, Zheng-Guo Cui, Hidekuni Inadera, Xu Jiang, Cheng-Ai Wu

Analysis of tumor mutation burden combined with immune infiltrates in endometrial cancer

Jun Zhang, Lanfen An, Xing Zhou, Rui Shi, Hongbo Wang

An artificial intelligence platform for the diagnosis and surgical planning of strabismus using corneal light-reflection photos

Keli Mao, Yahan Yang, Chong Guo, Yi Zhu, Chuan Chen, Jingchang Chen, Li Liu, Lifei Chen, Zijun Mo, Bingsen Lin, Xinliang Zhang, Sijin Li, Xiaoming Lin, Haotian Lin

Pulmonary tuberculosis as a risk factor for chronic obstructive pulmonary disease: a systematic review and meta-analysis

Huanhuan Fan, Fan Wu, Jing Liu, Weifeng Zeng, Silan Zheng, Heshen Tian, Haiqing Li, Huajing Yang, Zihui Wang, Zhishan Deng, Jieqi Peng, Youlan Zheng, Shan Xiao, Guoping Hu, Yumin Zhou, Pixin Ran

Development and validation of a nomogram combining hematological and imaging features for preoperative prediction of microvascular invasion in hepatocellular carcinoma patients

Qiang Zhou, Chenhao Zhou, Yirui Yin, Wanyong Chen, Chunxiao Liu, Manar Atyah, Jialei Weng, Yinghao Shen, Yong Yi, Ning Ren

Differential prognostic implications of gastric adenocarcinoma based on Lauren’s classification: a Surveillance, Epidemiology, and End Results (SEER)-based cohort study

Dehua Tang, Muhan Ni, Hao Zhu, Jun Cao, Lin Zhou, Shanshan Shen, Chunyan Peng, Ying Lv, Guifang Xu, Lei Wang, Xiaoping Zou

Cardiac indicator CK-MB might be a predictive marker for severity and organ failure development of acute pancreatitis

Bing Zhao, Silei Sun, Yihui Wang, Huihui Zhu, Tongtian Ni, Xing Qi, Lili Xu, Yuming Wang, Yi Yao, Li Ma, Ying Chen, Jun Huang, Weijun Zhou, Zhitao Yang, Huiqiu Sheng, Hongping Qu, Erzhen Chen, Jian Li, Enqiang Mao

Biomarkers and key pathways in atrial fibrillation associated with mitral valve disease identified by multi-omics study

Ming-Yang Li, Huan-Xin Chen, Hai-Tao Hou, Jun Wang, Xiao-Cheng Liu, Qin Yang, Guo-Wei He

SPECTnet: a deep learning neural network for SPECT image reconstruction

Wenyi Shao, Steven P. Rowe, Yong Du

Intravenous fluids for pain management in head and neck cancer patients undergoing chemoradiation

Charlotte I. Rivers, Austin J. Iovoli, Udit Chatterjee, Gregory M. Hermann, Anurag K. Singh

Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes

Christoph Knappich, Thomas Lang, Pavlos Tsantilas, Sofie Schmid, Michael Kallmayer, Bernhard Haller, Hans-Henning Eckstein

Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na/Ca channel-mediated mechanism

Li Yang, Yiqi Gong, Yao Tan, Lei Wu, Nevin Witman, Jijian Zheng, Jun Zhang, Wei Fu, Wei Wang

Rosavin suppresses osteoclastogenesis in vivo and in vitro by blocking the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways

Wenhao Zhang, Weijie Zhang, Liang Huo, Ying Chai, Zhiyang Liu, Zhenhu Ren, Chuangqi Yu

The difference between fasting and non-fasting lipid measurements is not related to statin treatment

Ming-Ming Liu, Jia Peng, Ye-Xuan Cao, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Ying Gao, Jian-Jun Li

Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry

Michael A. Cummings, Sung Jun Ma, Paul Van Der Sloot, Michael T. Milano, Deepinder P. Singh, Anurag K. Singh

A biomechanical comparison of a mesh suture to a polyblend suture in a porcine tendon model

Zhanwen Wang, Zeling Long, Hong Li, Hongbin Lu, Anne Gingery, Peter C. Amadio, Steven L. Moran, Chunfeng Zhao

Real-world big data demonstrates prevalence trends and developmental patterns of myopia in China: a retrospective, multicenter study

Erping Long, Xiaohang Wu, Xiaohu Ding, Yahan Yang, Xun Wang, Chong Guo, Xiayin Zhang, Kexin Chen, Tongyong Yu, Dongxuan Wu, Xutu Zhao, Zhenzhen Liu, Yizhi Liu, Haotian Lin

Comparison of posterior corneal elevation after SMILE and FS-LASIK in correcting myopia over −9.0 diopters

Yu Zhao, Yishan Qian, Xun Chen, Xueyi Zhou, Bing Qin, Xingtao Zhou

Homologous recombination repair gene mutations show no survival benefits in Chinese high-grade serous ovarian cancer patients

Zheng Feng, Hao Wen, Xingzhu Ju, Rui Bi, Xiaojun Chen, Wentao Yang, Xiaohua Wu

Germline and tumor BRCA1/2 mutations in Chinese high grade serous ovarian cancer patients

Gang Ji, Qianlan Yao, Longlong Bao, Jing Zhang, Qianming Bai, Xiaoli Zhu, Xiaoyu Tu, Rui Bi, Xiaoyan Zhou

Prolonged balloon occlusion of the lower abdominal aorta during pelvic or sacral tumor resection

Yi Luo, Mingyan Jiang, Jianguo Fang, Li Min, Yong Zhou, Fan Tang, Minxun Lu, Yitian Wang, Hong Duan, Chongqi Tu

Lung cancers and pulmonary nodules detected by computed tomography scan: a population-level analysis of screening cohorts

Caichen Li, Jing Liao, Bo Cheng, Jianfu Li, Hengrui Liang, Yu Jiang, Zixuan Su, Shan Xiong, Feng Zhu, Yi Zhao, Ran Zhong, Feng Li, Jianxing He, Wenhua Liang

Machine learning models to predict red blood cell transfusion in patients undergoing mitral valve surgery

Shun Liu, Rong Zhou, Xing-Qiu Xia, He Ren, Le-Ye Wang, Rui-Rui Sang, Mi Jiang, Chun-Chen Yang, Huan Liu, Lai Wei, Rui-Ming Rong

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

A comparison of perioperative safety for breast augmentation in cis- vs. trans patients

Kyle S. Gabrick, Fouad Chouiari, Kitae E. Park, Omar Allam, Mohammed Ali Mozaffari, John A. Persing, Michael Alperovich

Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration

Un Chul Park, Susanna S. Park, Bo Hee Kim, Sung Wook Park, Young Joo Kim, Whitney Cary, Johnathon D. Anderson, Jan A. Nolta, Hyeong Gon Yu

Single versus two-stage phalloplasty for transgender female-to-male patients: a systematic review of the literature

Maria T. Huayllani, Daniel Boczar, Humza Y. Saleem, Gabriela Cinotto, Francisco R. Avila, Oscar J. Manrique, Pedro Ciudad, Brian D. Rinker, Antonio J. Forte

The role of magnification correction in macular vessel density assessment: a contralateral eye study in anisometropia patients

Dan Fu, Meiyan Li, Li Zeng, Jianmin Shang, Zhiqiang Yu, Xingtao Zhou

Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas

Qingting Huang, Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade Jay Lu

Feasibility of a second-generation colon capsule in visualization of the upper gastrointestinal tract

Gangping Li, Yu Jin, Tao Bai, Wei Qian, Xiaoping Xie, Xiaohua Hou

Identification of hub genes and compounds controlling ovarian cancer stem cell characteristics via stemness indices analysis

Zhi Wang, Di Wu, Yu Xia, Bin Yang, Tao Xu

Developing and validating a novel nomogram used a competing-risks model for predicting the prognosis of primary fallopian tube carcinoma: a retrospective study based on the SEER database

Chengzhuo Li, Junyuan Li, Qiao Huang, Xiaojie Feng, Fanfan Zhao, Fengshuo Xu, Didi Han, Jun Lyu

SMURF1-mediated ubiquitylation of SHP-1 promotes cell proliferation and invasion of endometrial stromal cells in endometriosis

Yunmeng Bian, Li Yuan, Xiaoqian Yang, Lichun Weng, Yanli Zhang, He Bai, Jinhong Chen

Effect of norepinephrine challenge on cardiovascular determinants assessed using a mathematical model in septic shock: a physiological study

Huaiwu He, Siyi Yuan, Yun Long, Dawei Liu, Xiang Zhou, Can Ince

Comprehensive serum metabolic and proteomic characterization on cognitive dysfunction in Parkinson’s disease

Na Zhang, Chuanxi Tang, Qiong Ma, Wei Wang, Mingyu Shi, Xiaoyu Zhou, Fangfang Chen, Chengcheng Ma, Xue Li, Gang Chen, Dianshuai Gao

Impact of variceal eradication on rebleeding and prognosis in cirrhotic patients undergoing secondary prophylaxis

Xing Wang, Jinni Luo, Chuan Liu, Yanna Liu, Xiaoying Wu, Fengping Zheng, Zhuofu Wen, Hong Tian, Xiuqing Wei, Yunwei Guo, Jianzhong Li, Xiaoliang Chen, Jin Tao, Xiaolong Qi, Bin Wu

Interleukin-28A maintains the intestinal epithelial barrier function through regulation of claudin-1

Liangzi Li, Chao Zhou, Teming Li, Weidong Xiao, Min Yu, Hua Yang

Association between renal function and retinal neurodegeneration in Chinese patients with type 2 diabetes mellitus

Xia Gong, Wei Wang, Wangting Li, Ling Jin, Lanhua Wang, Jie Meng, Kun Xiong, Yuting Li, Xiao Han, Xiaoling Liang, Wenyong Huang

Personality differences in brain network mechanisms for placebo analgesia and nocebo hyperalgesia in experimental pain: a functional magnetic resonance imaging study

Yu Shi, Yaping Wang, Yanyan Zeng, Hongrui Zhan, Shimin Huang, Guiyuan Cai, Jianming Yang, Wen Wu

Risk factors for lymph node metastasis of the left recurrent laryngeal nerve in patients with esophageal squamous cell carcinoma

Chuangui Chen, Zhao Ma, Xiaobin Shang, Xiaofeng Duan, Jie Yue, Hongjing Jiang

Perception of femininity and attractiveness in Facial Feminization Surgery

Ann Hui Ching, Allister Hirschman, Xiaona Lu, Seija Maniskas, Antonio J. Forte, Michael Alperovich, John A. Persing

Distinct prognostic values of programmed death-ligand 1 and programmed cell death protein 1 in lung adenocarcinoma and squamous cell carcinoma patients

Shuo Wang, Xiujuan Qu, Zhi Li, Xiaofang Che, Lili Cao, Xianghong Yang, Xuejun Hu, Ling Xu, Kezuo Hou, Yibo Fan, Ti Wen, Yunpeng Liu

A multi-center survey on the postpartum mental health of mothers and attachment to their neonates during COVID-19 in Hubei Province of China

Sicong Peng, Yi Zhang, Hongyan Liu, Xiaona Huang, Douglas James Noble, Lixia Yang, Wei Lu, Yahui Luo, Huaping Zhu, Li Cao, Chunhua Liu, Yang Chen, Pei Zhang, Shiwen Xia, Anuradha Narayan

Robotic and laparoscopic sacrocolpopexy for pelvic organ prolapse: a systematic review and meta-analysis

Jiang Yang, Yong He, Xiaoyi Zhang, Zhi Wang, Xiaohu Zuo, Likun Gao, Li Hong

Immunoglobulin (Ig) G4-related sclerosing cholangitis in patients resected for presumed perihilar cholangiocarcinoma: a 10-year experience

Lei Feng, Zhen You, Dongyang Ma, Lvjun Yan, Hua Cheng, Junhe Gou, Liping Chen

A clinical diagnostic model based on an eXtreme Gradient Boosting algorithm to distinguish type 1 diabetes

Xiaohan Tang, Rui Tang, Xingzhi Sun, Xiang Yan, Gan Huang, Houde Zhou, Guotong Xie, Xia Li, Zhiguang Zhou

Oral care and oral assessment guide in breast cancer patients receiving everolimus and exemestane: subanalysis of a randomized controlled trial (Oral Care-BC)

Masahiro Umeda, Yoshihide Ota, Kosuke Kashiwabara, Naoki Hayashi, Mariko Naito, Toshinari Yamashita, Hirofumi Mukai, Katsuhiko Nakatsukasa, Takeshi Amemiya, Ken-Ichi Watanabe, Hironobu Hata, Yuichiro Kikawa, Naoki Taniike, Takashi Yamanaka, Sachiyo Mitsunaga, Kazuhiko Nakagami, Moriyasu Adachi, Naoto Kondo, Yasuyuki Shibuya, Naoki Niikura

Concurrent bile duct resection versus concomitant thrombectomy for hepatocellular carcinoma associated with bile duct tumor thrombus: a propensity score matching analysis

Jin-Kai Feng, Zhen-Hua Chen, Ju-Xian Sun, Jia-Yi Wu, Wei-Xing Guo, Jie Shi, Yong-Gang Wei, Jian-Yin Zhou, Zhi-Bo Zhang, Mao-Lin Yan, Shu-Qun Cheng

Muscle damage in response to a single bout of high intensity concentric exercise in patients with Pompe disease

Márk Váczi, Szilvia Anett Nagy, Tamás Kőszegi, Bernadette Misovics, Edina Szabó, Éva Müller, Gábor Perlaki, Gergely Orsi, József Pál, Péter Bogner, Zsolt Illes

Characteristics and prognosis of telangiectatic osteosarcoma: a population-based study using the Surveillance, Epidemiology and End Results (SEER) database

Mingfang Xu, Nan Dai, Xueqin Yang, Wei Guan, Yu Pu, Dong Wang, Liangjun Yin, Mao Nie

Study Protocol

Targeted temperature management at 33 degrees Celsius in patients with high-grade aneurysmal subarachnoid hemorrhage: a protocol for a multicenter randomized controlled study

Xin Qu, Feng Shang, Hao Zhao, Meng Qi, Weitao Cheng, Yueqiao Xu, Lidan Jiang, Wenjing Chen, Ning Wang, Hongqi Zhang

Review Article

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

The modern approach to esophageal palliative and emergency surgery

Anny Godin, Moishe Liberman

Measurements of deposited aerosol dose in infants and small children

Timothy E. Corcoran

Inhaled pulmonary vasodilators: a narrative review

Kai Liu, Huan Wang, Shen-Ji Yu, Guo-Wei Tu, Zhe Luo

Therapeutic strategies in Wilson disease: pathophysiology and mode of action

Wolfgang Stremmel, Ralf Weiskirchen

Targeting vascular endothelial growth factor using retinal gene therapy

Sook H. Chung, Sonia L. Frick, Glenn Yiu

The role of bile acids in cholestatic liver injury

Shi-Ying Cai, James L. Boyer

De novo gastroesophageal reflux disease esophageal surgery in bariatrics: a literature review and analysis of the current treatment options

Rene Aleman, Emanuele Lo Menzo, Samuel Szomstein, Raul J. Rosenthal

Morphea: progress to date and the road ahead

Laila Abbas, Adrienne Joseph, Elaine Kunzler, Heidi T. Jacobe

Propensity score matching with R: conventional methods and new features

Qin-Yu Zhao, Jing-Chao Luo, Ying Su, Yi-Jie Zhang, Guo-Wei Tu, Zhe Luo

Artificial intelligence for molecular neuroimaging

Amanda J. Boyle, Vincent C. Gaudet, Sandra E. Black, Neil Vasdev, Pedro Rosa-Neto, Katherine A. Zukotynski

Management of left ventricular thrombus: a narrative review

Jose B. Cruz Rodriguez, Kazue Okajima, Barry H. Greenberg

Clinical examination and classification systems of congenital clubfoot: a narrative review

Federico Canavese, Alain Dimeglio

Paraesophageal hernia: to fundoplicate or not?

Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan

Narrative review of pharmacotherapy for transthyretin cardiac amyloid

Jose B. Cruz Rodriguez, Jose A. Tallaj

Optimal diuretic strategies in heart failure

Sarabjeet S. Suri, Salpy V. Pamboukian

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Frank Tacke, Ralf Weiskirchen

Esophageal disease in lung transplant patients

John S. Young, Antonio Coppolino

Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction

Vaia Florou, Sonam Puri, Ignacio Garrido-Laguna, Breelyn A. Wilky

Covert clues: the non-hallmark cutaneous manifestations of dermatomyositis

Rochelle L. Castillo, Alisa N. Femia

Animal models of diabetic retinopathy

Jose Quiroz, Amirfarbod Yazdanyar

Biomarkers of therapeutic response with immune checkpoint inhibitors

Poorva Bindal, Jhanelle E. Gray, Theresa A. Boyle, Vaia Florou, Sonam Puri

Immuno-oncology: a narrative review of gastrointestinal and hepatic toxicities

Stergios Boussios, Matin Sheriff, Elie Rassy, Michele Moschetta, Eleftherios P. Samartzis, Rachel Hallit, Agne Sadauskaite, Konstantinos H. Katsanos, Dimitrios K. Christodoulou, Nicholas Pavlidis

Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry

Renato Salvador, Mario Costantini, Salvatore Tolone, Pietro Familiari, Ermenegildo Galliani, Bastianello Germanà, Edoardo Savarino, Stefano Merigliano, Michele Valmasoni

Fugitive aerosols in the intensive care unit: a narrative review

Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin

Endovascular embolization in renal trauma: a narrative review

Tyler Andrew Smith, Adriene Eastaway, Duncan Hartt, Keith Bertram Quencer

Narrative review in the current role of angiotensin receptor-neprilysin inhibitors

Jose B. Cruz Rodriguez, Cameron Cu, Tariq Siddiqui

Dairy consumption and hepatocellular carcinoma risk

Bodo C. Melnik

Review of aerosol delivery in the emergency department

Patricia A. Dailey, Courtney M. Shockley

The dark side of immunotherapy

Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami

Revisiting hemochromatosis: genetic vs. phenotypic manifestations

Gregory J. Anderson, Edouard Bardou-Jacquet

Molecular landscape of head and neck cancer and implications for therapy

Camile S. Farah

Autoimmune hepatitis—is histology conclusive?

Andrea Beer, Hans Peter Dienes

Hyperthermic intrathoracic chemotherapy (HITHOC): narrative review of the current literature, recommendations and future studies

Till Markowiak, Christopher Larisch, Hans-Stefan Hofmann, Michael Ried

The role of gut microbiome in modulating response to immune checkpoint inhibitor therapy in cancer

Abdul Rafeh Naqash, Alba J. Kihn-Alarcón, Chara Stavraka, Kathleen Kerrigan, Saman Maleki Vareki, David James Pinato, Sonam Puri

Reporting of coronavirus disease 2019 prognostic models: the transparent reporting of a multivariable prediction model for individual prognosis or diagnosis statement

Liuqing Yang, Qiang Wang, Tingting Cui, Jinxin Huang, Naiyang Shi, Hui Jin

Evolving treatment paradigms in esophageal cancer

Ilit Turgeman, Irit Ben-Aharon

Robotics and minimally invasive esophageal surgery

Ealaf Shemmeri, Jon O. Wee

Inhaled antibiotics during mechanical ventilation—why it will work

Maxime Desgrouas, Stephan Ehrmann

A path to successful patient outcomes through aerosol drug delivery to children: a narrative review

Arzu Ari

Narrative review of vascular iatrogenic trauma and endovascular treatment

Tyler Andrew Smith, David Gage, Keith Bertram Quencer

Splenic trauma: endovascular treatment approach

Maxwell Cretcher, Catherine E. P. Panick, Alexander Boscanin, Khashayar Farsad

Gene therapy for inherited retinal diseases

Yan Nuzbrokh, Sara D. Ragi, Stephen H. Tsang

Polishing the crystal ball: mining multi-omics data in dermatomyositis

Rochelle L. Castillo, Alisa N. Femia

Pruritus in autoimmune connective tissue diseases

Hee Joo Kim

Evaluating safety and compatibility of anti-tumor necrosis factor therapy in patients with connective tissue disorders

Jordan T. Said, Scott A. Elman, Joseph F. Merola

Advances in cutaneous vasculitis research and clinical care

Avrom Caplan, Robert G. Micheletti

CAR T-cell therapy in mature lymphoid malignancies: clinical opportunities and challenges

Mayur Narkhede, Amitkumar Mehta, Stephen M. Ansell, Gaurav Goyal

Essentials for aerosol delivery to term and pre-term infants

Andrew R. Clark

Fluorescence-guided surgery of the esophagus

Paul Chandler, Ory Wiesel, Danny A. Sherwinter

Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes

Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique

It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis

Amit Khurana, Nilofer Sayed, Prince Allawadhi, Ralf Weiskirchen

Antiplatelet and anticoagulation strategies for left ventricular assist devices

Renzo Y. Loyaga-Rendon, Toshinobu Kazui, Deepak Acharya

Updates in pharmacotherapy of heart failure with reduced ejection fraction

Clifton Espinoza, Haider Alkhateeb, Tariq Siddiqui

The CLASI, a validated tool for the evaluation of skin disease in lupus erythematosus: a narrative review

Srita Chakka, Rebecca L. Krain, Josef Symon S. Concha, Benjamin F. Chong, Joseph F. Merola, Victoria P. Werth

Diagnostic management of nonalcoholic fatty liver disease: a transformational period in the development of diagnostic and predictive tools—a narrative review

Natalia Rosso, Adam M. Stephenson, Pablo J. Giraudi, Claudio Tiribelli

Dermatomyositis and malignancy: should all patients with dermatomyositis undergo malignancy screening?

Urmi Khanna, Fabrizio Galimberti, Yumeng Li, Anthony P. Fernandez

Pluripotent stem cell therapy for retinal diseases

Ishrat Ahmed, Robert J. Johnston Jr, Mandeep S. Singh

Liver failure—future challenges and remaining questions

Peter Lemmer, Josef Christian Pospiech, Ali Canbay

The modern approach to esophagectomy—review of the shift towards minimally invasive surgery

Daniel P. Dolan, Scott J. Swanson

Narrative review: the holy grail: update on pharmacotherapy for heart failure with preserved ejection fraction

Pablo Alejandro Paz, Barbara Daniela Mantilla, Erwin E. Argueta, Debabrata Mukherjee

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

Rolf Teschke, Jack Uetrecht

Non-alcoholic fatty liver diseases: current challenges and future directions

Elke Roeb

Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma

Jeff Rytlewski, Mohammed M. Milhem, Varun Monga

Endovascular management of pelvic trauma

Arlene Weir, Padraic Kennedy, Stella Joyce, David Ryan, Liam Spence, Mark McEntee, Michael Maher, Owen O’Connor

Narrative Review of the objective analysis of long-term outcome of the Ponseti technique: experience from Dallas

B. Stephens Richards

Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

Environmental triggers of dermatomyositis: a narrative review

Christina E. Bax, Spandana Maddukuri, Adarsh Ravishankar, Lisa Pappas-Taffer, Victoria P. Werth

The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis—a narrative review article

Wolfgang Stremmel, Martina Lukasova, Ralf Weiskirchen

Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

Sangwan Park, Brian C. Leonard, Vijay Krishna Raghunathan, Soohyun Kim, Jennifer Y. Li, Mark J. Mannis, Christopher J. Murphy, Sara M. Thomasy

Dermatomyositis autoantibodies: how can we maximize utility?

Luqman Mushila Hodgkinson, Tiffany Tingshuen Wu, David Franklin Fiorentino

Systematic review of fertility preservation options in transgender patients: a guide for plastic surgeons

Maria Yan, Samyd S. Bustos, Doga Kuruoglu, Pedro Ciudad, Antonio J. Forte, Esther A. Kim, Gabriel Del Corral, Oscar J. Manrique

Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery

Luigi Bonavina

New frontiers in esophageal radiology

Eric J. Schmidlin, Ritu R. Gill

Pulmonary vasodilator use in continuous-flow left ventricular assist device management

Preethi Pirlamarla, Eduardo Rame, Charles Hoopes, Indranee Rajapreyar

Administration of dry powders during respiratory supports

Wei-Ren Ke, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Patricia Tang, Lan Chen, Donghao Chen, Hak-Kim Chan

Human cutaneous B cells: what do we really know?

Irina Lerman, Drew C. Mitchell, Christopher T. Richardson

Narrative Review of Carotid disease and the kidney

Luca Zanoli, Dimitri P. Mikhailidis

Aerosol delivery via noninvasive ventilation: role of models and bioanalysis

Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mohamed E. A. Abdelrahim

Surgical techniques of phalloplasty in transgender patients: a systematic review

Daniel Boczar, Maria T. Huayllani, Humza Y. Saleem, Gabriela Cinotto, Francisco R. Avila, Salam Kassis, Xiaona Lu, Brian D. Rinker, Antonio J. Forte

Artificial intelligence in molecular imaging

Edward H. Herskovits

Aerosol delivery via invasive ventilation: a narrative review

Hui-Ling Lin, James B. Fink, Huiqing Ge

Narrative review of generative adversarial networks in medical and molecular imaging

Kazuhiro Koshino, Rudolf A. Werner, Martin G. Pomper, Ralph A. Bundschuh, Fujio Toriumi, Takahiro Higuchi, Steven P. Rowe

A narrative review of the role of necroptosis in liver disease: a double-edged sword

Xuehui Li, Guanjun Dong, Huabao Xiong, Hongyan Diao

The basic science of optic nerve regeneration

Lindsay Fague, Yin Allison Liu, Nicholas Marsh-Armstrong

Erratum

Erratum to cerebrotendinous xanthomatosis with peripheral neuropathy: a clinical and neurophysiological study in Chinese population

Shu Zhang, Wei Li, Rui Zheng, Bing Zhao, Yongqing Zhang, Dandan Zhao, Cuiping Zhao, Chuanzhu Yan, Yuying Zhao

Erratum to high concentrations of H7 human embryonic stem cells at the point of care for acute myocardial infarction

Editorial office

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.