About atm

Manuscript Submission

Reprint & Permission

Advertising

Contact us

Focused Issues more

Focus on “Critical Care” More >>
Focus on “Acute Respiratory Distress Syndrome” More >>
Focus on “II Meeting on Traslational Research on Melanoma by the Spanish Melanoma Group (GEM)” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

Endorsement
Endorsement
Endorsement

the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Sponsored by

Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

Sponsored by

Original Article

Detection of MET amplification in gastroesophageal tumor specimens using IQFISH
Jan Trøst Jørgensen, Karsten Bork Nielsen, Jens Mollerup, Anna Jepsen, Ning Go

Editorial

River blindness goes beyond the eye: autoimmune antibodies, cross-reactive with Onchocerca volvulus antigen, detected in brain of patients with Nodding syndrome
Christoph Kaiser, Sébastien D. S. Pion
Alectinib in untreated anaplastic lymphoma kinase-positive nonsmall cell lung cancer
Anne-Marie Ruppert, Xavier Mignard, Marie Wislez
New evidence for nodding disease as an autoimmune reaction to Onchocerca volvulus
Michael J. Boivin
Antibody-drug conjugate targeting protein tyrosine kinase 7, a receptor tyrosine kinase-like molecule involved in WNT and vascular endothelial growth factor signaling: effects on cancer stem cells, tumor microenvironment and whole-body homeostasis
Masaru Katoh
Creative technology advances tissue preservation
Mandi J. Lopez
Drugs targeting protease-activated receptor-4 improve the antithrombotic therapeutic window
Shauna L. French, Justin R. Hamilton
Non-vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunction
Ahsan A. Khan, Gregory Y. H. Lip
Prediction models to advance individualized resuscitation in trauma hemorrhage and acute traumatic coagulopathy (ATC): even the longest journey starts with first steps—Lao-Tzu (Chinese philosopher)
Marc Maegele
Novel regulators of PD-L1 expression in cancer: CMTM6 and CMTM4—a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors
Denira Imamovic, Semir Vranic
Predictors of response and resistance to checkpoint inhibitors in solid tumors
Sanjana V. Rao, Amy E. Moran, Julie N. Graff
Nrf2: a promising trove for diabetic wound healing
Amruta Jindam, Veera Ganesh Yerra, Ashutosh Kumar
Sodium-glucose cotransporter 2 inhibitors and death and heart failure in type 2 diabetes
Hidekatsu Yanai
Lysosomal function in β-cell survival during glucolipotoxicity
Ana Batista- Gonzalez, Rajat Singh
Telomeric zinc-finger associated protein (TZAP): a new player in telomere diseases?
Benedetta Donati, Luca Valenti
Canagliflozin lowers blood sugar, but does it also lower cardiovascular risk? Maybe not
Thomas F. Heston, Anndres H. Olson, Nicholas R. Randall
Comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors: SGLT2 inhibitors in the real world
Richard J. MacIsaac, Elif I. Ekinci
Semaglutide—the “new kid on the block” in the field of glucagonlike peptide-1 receptor agonists?
Cristian Guja, Rucsandra Dănciulescu Miulescu
Cardiovascular outcome studies with glucagon-like peptide 1 receptor agonists—what will REWIND add?
Keith C. Ferdinand, Indrajeet Mahata
The ODYSSEY DM-DYSLIPIDEMIA trial: confirming the benefits of alirocumab in diabetic mixed dyslipidemia
Paul Chan, Li Shao, Brian Tomlinson, Zhong-Min Liu
Empagliflozin reduces albuminuria—a promise for better cardiorenal protection from the EMPA-REG OUTCOME trial
Rikke Borg, Frederik Persson

Perspective

Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers
Bob T. Li, Dennis Stephens, Jamie E. Chaft, Charles M. Rudin, David R. Jones, Valerie W. Rusch, Andreas Rimner, James M. Isbell

Letter to the Editor

Radiation risk from lung cancer screening
Cristiano Rampinelli, Paolo De Marco, Massimo Bellomi

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal

Commentary

Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface


Editorial


Perspective



Review Article


Original Article


Case Report


Meet the Professor



Big-data Clinical Trial Column


Technical Note


Column in Hypertension: Editorial