About atm

Manuscript Submission


Contact us

Focused Issues more

Focus on “The Human Microbiome in Urologic Health and Disease” More >>
Focus on “Treatment for Hepatitis B” More >>
Focus on “Extracorporeal Life Support” More >>


Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Sponsored by

Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

Sponsored by

Original Article

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014
Ilhwan Yeo, Hasan Ahmad, Wilbert S. Aronow
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Review Article

MET in human cancer: germline and somatic mutations
Elizabeth A. Tovar,, Carrie R. Graveel
Helping prometheus: liver protection in acute hemorrhagic shock
Nils T. Veith, Tina Histing, Michael D. Menger, Tim Pohlemann, Thomas Tschernig
External beam techniques to boost cervical cancer when brachytherapy is not an option—theories and applications
Omar Mahmoud, Sarah Kilic, Atif J. Khan, Sushil Beriwal, William Small Jr
Biomarker-guided antibiotic therapy—strengths and limitations
David Nora, Jorge Salluh, Ignacio Martin-Loeches, Pedro Póvoa

Case Report

Pulmonary embolism in transit
Anna Koulova, Ramin Malekan, Wilbert S. Aronow, Howard A. Cooper
Multi-vessel giant coronary artery aneurysm in an elderly female
Rami N. Khouzam, Jonathan D. Gardner, Ritin Bomb, Anthony A. Holden

Big-data Clinical Trial Column

Drawing Nomograms with R: applications to categorical outcome and survival data
Zhongheng Zhang, Michael W. Kattan Kattan


Aspirin monotherapy vs. dual antiplatelet therapy in diabetic patients following coronary artery bypass graft (CABG): where do we stand?
Salem Salem, Sameh Askandar, Rami N. Khouzam
Glioma, glutamate (SLC7A11) and seizures—a commentary
Vani Santosh, Palavalasa Sravya
Neuropsychological outcomes after subthalamic nucleus deep brain stimulation
Terry Coyne
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Neuropsychological outcomes from deep brain stimulation—stimulation versus micro-lesion
Tammy Pham, Jeff M. Bronstein
Prolonged exposure to acetaminophen during pregnancy reduces testosterone production by the human fetal testis
Mehmet Gokhan Culha, Ege Can Serefoglu
Inflammation in the spotlight—clinical relevance of genetic variants affecting nuclear factor κB and tumor necrosis factor receptor 1
Francisco J Ortega, José M Fernández-Rea
Cancer exosomes: wanted by many, explored by few, waiting for one
Hien Dang, Xuelian Zhao, Chi-Wing Chow
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
Therapeutic targeting of dysregulated cellular communication
Simone Schiavone, Annalisa Contursi, Rosalia Grande, Paola Patrignani
Immunosuppressive role of extracellular vesicles: HLA-G, an important player
Cristina Grange, Giovanni Camussi
Inhibition of SOX9 may be an effective target for increasing radiosensitivity in gastrointestinal cancer
Ming-Feng Wei, Sung-Hsin Kuo
Modular versus nonmodular tibial inserts in total knee arthroplasty: what are the differences?
Asim M. Makhdom, Javad Parvizi
Outerbridge grade IV cartilage lesions in the hip identified at arthroscopy
Michael McLean, Tony Whyte, Neal L. Millar
Management of hypertension in patients undergoing surgery
Wilbert S. Aronow


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.




Review Article

Original Article

Case Report

Letter to the Editor

Review Article on Treatment for Hepatitis B