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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Original Article on Translational Neurodegeneration

Meta-analysis of the association between CD33 and Alzheimer’s disease
Yu-Ting Jiang, Hai-Yan Li, Xi-Peng Cao, Lan Tan
The expression of KATP channel subunits in alpha-synucleintransfected MES23.5 cells
Shuai-Shuai Han, Qian Jiao, Ming-Xia Bi, Xi-Xun Du, Hong Jiang
The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Association of lectin-like oxidized low density lipoprotein receptor 1 (OLR1) polymorphisms with late-onset Alzheimer disease in Han Chinese
Zuo-Teng Wang, Xiao-Ling Zhong, Meng-Shan Tan, Hui-Fu Wang, Chen-Chen Tan, Wei Zhang, Zhan-Jie Zheng, Ling-Li Kong, Lan Tan, Li Sun
Characterization of the locomotor activities of zebrafish larvae under the influence of various neuroactive drugs
Fei Li, Jia Lin, Xiuyun Liu, Wenhui Li, Yifeng Ding, Yunjian Zhang, Shuizhen Zhou, Ning Guo, Qiang Li
Adult-onset Krabbe disease in two generations of a Chinese family
Tongxia Zhan, Chuanzhu Yan, Kunqian Ji, Pengfei Lin, Lingyi Chi, Xiuhe Zhao, Yuying Zhao

Review Article on Translational Neurodegeneration

Tau in neurodegenerative disease
Yong-Lei Gao, Nan Wang, Fu-Rong Sun, Xi-Peng Cao, Wei Zhang, Jin-Tai Yu
Microglial priming in Alzheimer’s disease
Jun-Wei Li, Yu Zong, Xi-Peng Cao, Lin Tan, Lan Tan
Innate immune activation in Alzheimer’s disease
Ming-Ming Wang, Dan Miao, Xi-Peng Cao, Lin Tan, Lan Tan
The role of UNC5C in Alzheimer’s disease
Quan Li, Bai-Ling Wang, Fu-Rong Sun, Jie-Qiong Li, Xi-Peng Cao, Lan Tan

Surgical Technique

Resection of esophageal diverticulum through uniportal video-assisted thoracoscopic surgery
Alfonso Fiorelli, Anna Cecilia Izzo, Ettore Arrigo, Francesco Sgalambro, Maria Antonietta Lepore, Massimo Cajozzo, Sergio Castorina, Attilio Ignazio Lo Monte, Mario Santini, Francesco Paolo Caroni

Big-data Clinical Trial Column

Instrumental variable analysis in the presence of unmeasured confounding
Zhongheng Zhang, Md Jamal Uddin, Jing Cheng, Tao Huang


Aortic valve replacement in young patients: should the biological prosthesis be recommended over the mechanical?
Alberto Alperi, Daniel Hernandez-Vaquero, Isaac Pascual, Rocio Diaz, Iria Silva, Ruben Alvarez-Cabo, Pablo Avanzas, Cesar Moris
The choice of heart valve prosthesis for aortic valve replacement in the young: about choices and consequences
Thierry Bove
Bioprosthetic aortic valve replacement: a telltale from the young
Athanasios Antoniou, Amer Harky, John Yap, Kulvinder Kulvinder Lall, Mohamad Bashir
Can we exonerate GLP-1 receptor agonists from blame for adverse pancreatic events?
Conor F. Murphy, Carel W. le Roux
Translating patient related outcome measures into practice— lessons to be learnt
Waseem Majeed, Hood Thabit
Does continuous glucose monitoring during pregnancy improve glycaemic and health outcomes in women with type 1 diabetes?— what the CONCEPTT trial adds
Diane Farrar, Matthew D. Campbell
Improved outcome of bilateral compared to single internal thoracic artery grafting: patient’s selection or technical skill?
Antonio M. Calafiore, Carlo Maria De Filippo, Massimiliano Foschi, Michele Di Mauro
Untangling the bilateral versus single internal mammary coronary artery bypass grafting debate
Emile Voisine, Pierre Voisine
BPI fold-containing family a member 2 as a biomarker of acute kidney injury—close but no (clinical) cigar?
Patrick M. Honore, David De Bels, Herbert D. Spapen
Pioglitazone and cardiovascular risk in T2DM patients: is it good for all?
Muhammad Abdul-Ghani, Amin Jayyous, Nidal Asaad, Sherif Helmy, Jassim Al-Suwaidi
AdDIT Editorial comment—challenges in medication treatment of renal and cardiovascular diseases and risk factors in adolescents with type 1 diabetes
Fariba Ahmadizar, Anke H. Maitland-van der Zee
The role of glucagon-like peptide-1 receptor agonists in cardiovascular disease prevention in type 2 diabetes mellitus: evidence from the most recent clinical trials
S. John Weisnagel
Anti-diabetic agents and heart health: how to use new diabetes medications in a global strategy for the prevention of cardiovascular complications in type 2 diabetes
Carmine Gazzaruso, Adriana Coppola, Tiziana Montalcini, Colomba Falcone


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.


Review Article

Original Article

Technical Note