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Focused Issue on Medical Aerosol in Acute and Critical Care

This Focused Issue on “Medical Aerosol in Acute and Critical Care” is edited by Dr. James B Fink and Dr. Zhe Luo.

Focused Issue on Hemodynamic Monitoring in Critically Ill Patients

This Focused Issue on “Hemodynamic Monitoring in Critically Ill Patients” is edited by Dr. Glenn Hernández and Dr. Guo-wei Tu.

Focused Issue on Current State of Intraoperative Imaging

This focused issue on “Current State of Intraoperative Imaging” is edited by Dr. Sheeraz Qureshi, from department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Focus on “Pediatric Acute Respiratory Distress Syndrome” edited by Dr. Jan Hau Lee, Prof. Ira M. Cheifetz, and Dr. Martin Kneyber

This focused issue presents a collection of review articles on pediatric acute respiratory distress syndrome (PARDS). Despite a trend toward improved outcomes over the past decade or so, PARDS still leads to significant morbidities and mortality. This collection of review articles provides a comprehensive overview on this important disease in the pediatric critical care environment.

Application of the CARE Guideline as reporting standard in the Annals of Translational Medicine

The Annals of Translational Medicine welcomes case reports which are supposed to report new observations of diseases, clinical findings or novel/unique treatment outcomes relevant to practitioners in the fields of medicine.

Focused Issue on Lung Emphysema

This focused issue on Lung Emphysema is edited by Dr. Bassam Redwan, MD, from Department of Thoracic Surgery, Klinikum Westfalen, Lünen, Germany.

Focused Issue on Lipid-Modifying Therapies Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

This Focused Issue on “Lipid-Modifying Therapies Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)” is edited by Dr. Constantine E. Kosmas, Director of Nuclear Cardiology and Lipid Clinic, Cardiology Unlimited, P.C., New York, NY, USA.

Focused Issue on Tumor Associated Macrophages in Solid Tumor: Friend or Foe

This focused issue on Tumor Associated Macrophages in Solid Tumor: Friend or Foe is edited by Dr. Gaurav Pandey, PhD, from Washington University School of Medicine, St. Louis, MO, USA.

Focused Issue on Current Trends and Advancements in Spine Surgery

In this focused issue of Annals of Translational Medicine, world-renowned leaders, academics, and physicians contribute their expertise and knowledge regarding the latest cutting-edge developments in the field of spine surgery. Trends discussed in this issue include the various ways in which the changing financial aspects and models of spine surgery are affecting the care delivered to patients.

Focused Issue on 10th Annual Meeting of the Rheumatologic Dermatology Society

The 10th Annual National Meeting of the RDS was held at the Wyndham Grand Chicago Riverfront Hotel on October 20, 2018 in Chicago, Illinois, USA in conjunction with the annual national meeting of the ACR. With the authors’ permission, the Annals of Translational Medicine has kindly agreed to publish abstracts of the presentations that were given at the 2018 RDS meeting. All the meeting abstracts could be found here: http://atm.amegroups.com/issue/view/875.

Focused Issue on Perioperative Management of Patients with Undergoing Mechanical Circulatory Support

This Focused Issue on “Perioperative Management of Patients with Undergoing Mechanical Circulatory Support” is edited by Kamen Valchanov, MD, BSc, FRCA, FFICM, from Department of Anaesthesia and Intensive Care, Royal Papworth Hospital, Cambridge, UK.

Focused Issue on Cancer Metastasis: Molecular Signaling and Therapeutic

This Focused Issue on “Cancer Metastasis: Molecular Signaling and Therapeutic” is edited by Dr. Khalid Sossey-Alaoui, PhD, from Division of Cancer Biology, MetroHealth Medical Research Center, MetroHealth System, Cleveland, Ohio, USA.

Focused Issue on Structural Heart Disease: The Revolution

This focused issue on “Structural Heart Disease: The Revolution” is edited by Dr. Da-niel Hernandez-Vaquero from Cardiac Surgery Department, Heart Area, Hospital Uni-versitario Central de Asturias, Oviedo, Spain.

ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

Focused Issue: Recent Developments in Cataract Surgery

This ATM focused issue on Recent Developments in Cataract Surgery is edited by Dr. Andrzej Grzybowski, Professor of Ophthalmology, Chair of Department of Ophthalmology, University of Warmia and Mazury, Olsztyn; Head of Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland.

Focused Issue on Neurological Diseases

This focused issue on “Neurological Diseases” is edited by Dr. Wei-Hai Xu, Department of Neurology, Peking Union Medical College Hospital, Beijing, China.

Focus on “Wilson’s disease: From Genetics to Management of Disease” edited by Dr. Ralf Weiskirchen and Dr. Wolfgang Stremmel

In this focused issue “Wilson Disease: From Genetics to Management of Disease”, leading experts working in the field of Wilson disease have summarized recent findings and advances in our understanding of this copper overload disease in regard to experimental and clinical aspects. The present knowledge on genetics and pathophysiology in relation to diagnostic and therapeutic procedures is our special interest. Challenges in diagnosis, anti-copper therapies, and clinical practice guidelines will be discussed.

Focused Issue on Strategies to Achieve Long-term Success of Lung Transplantation

This focused issue on “Strategies to Achieve Long-term Success of Lung Transplantation is edited by Dr. Masaaki Sato and Dr. Dong Tian, Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Focused Issue on Stem Cell and Clinical Application

This focusedissue on “Stem Cell and Clinical Application” is edited by Dr. Ling Lu, fromDivision of Liver Surgery, the First Affiliated Hospital of Nanjing MedicalUniversity, Nanjing, China

Focused Issue on The Immature Spine

This focused issue is edited by Dr. Federico Canavese, from Department of Pediatric Orthopedic Surgery, University Hospital Estaing, 1 place Lucie et Raymond Aubrac, Clermont Ferrand 63003, France.

Focus on “Spinal Tumor Surgery” edited by Dr. Matthew L. Goodwin and Dr. Daniel M. Sciubba

This special issue of Annals of Translational Medicine focuses on tumors in and around the spine. The field of spine tumor surgery is undergoing a transition period, as multidisciplinary care of the patient with the spinal tumor has become the standard of care.

Focus on: “Application of Artificial Intelligence to Radiology” edited by Dr. Timothy Deyer and Dr. Amish Doshi

In this focused issue of the Annals of Translational Medicine “Application of Artificial Intelligence to Radiology”, we explore the use of AI in to specific clinical and operational problems in Radiology.

Focus on “Pompe Disease” edited by Dr. Rosa Puertollano and Dr. Nina Raben

In this special issue of Annals of Translational Medicine, well distinguished clinicians, academic researchers, industry scientists, and patient advocates address recent advances and challenges in current and future therapies for Pompe disease, a prototypical lysosomal storage disorder. As is the case with many maladies, the history of Pompe disease, a severe neuromuscular disorder, is a reflection of the accelerating pace of basic science discoveries and the speed with which scientific knowledge is translated into medical progress.

Focus on “Diagnostic and Therapeutic Advances in the Management of Lung Cancer” edited by Dr. Kassem Harris and Dr. Samjot Singh Dhillon

Lung cancer remains the leading cause of cancer-related mortality worldwide. The last decade has witnessed multiple encouraging advances in the diagnosis and management of patients with lung cancer. The current issue provides focused reviews contributed by experts in the field with up-to-date information on a variety of topics related to management of lung cancer in an open access format.

ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

ATM New Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that, effective June 2019, Dr. Yinghao Sun will be taking over as co-the Editor-in-Chief in tandem with Dr. Xuehao Wang and Dr. Jianxing He.

Dr. Yinghao Sun is a Chief Physician, PhD Supervisor, an Academician of the Chinese Academy of Engineering, the Chief Scientist of 973 programs, and the winner of Ho Leung Ho Lee Foundation Award. He is currently the President of the Second Military Medical University, and he is the Director of the Department of Urology. He is also the Director of the Research Institute for Prostatic Disease of the PLA, and the Director of Changhai da Vinci Robotic Surgery Training Center. Dr. Sun specializes in clinical diagnosis, treatment, and research of urological tumors and urolithiasis, as well as practice and innovate techniques for minimally invasive urological techniques.

ATM New Honorary Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that Dr. Rafael Rosell, former Editor-in-Chief of the journal, will continuously serve on the editorial board as the Honorary Editor-in-Chief from June 2019.

First of all, we would like to sincerely thank Dr. Rafael Rosell for his hard work and dedication since 2015, without which the journal would not be the success it is today.

Focus on “Lower extremity arthroplasty” edited by Dr. Nipun Sodhi, Dr. Joseph O. Ehiorobo, Dr. Hiba K. Anis, Dr. Assem A. Sultan and Dr. Michael A. Mont.

This special section of Annals of Translational Medicine focuses on lower extremity arthroplasty, especially knee and hip pathologies. In this section, a multitude of pertinent topics for orthopaedic surgeons as well as for the general patient population are reviewed.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” edited by Dr. Bo Li

Ever since an awareness of two distinct cultural conceptions of healthcare has emerged, the debate concerning whether evidence-based medicine and Traditional Chinese medicine (TCM) are incompatible or whether they can in fact be unified, has continued.

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease

In this focused issue of the Annals of Translational Medicine Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease”, multiple manuscripts in this special issue address and review recent developments in the realm of antithrombotic therapy and reversal, intervention by both invasive and non-invasive means, and current challenges.

Focused Issue on Innovations and Updates in Esophageal Surgery

This Focused Issue on “Innovations and Updates in Esophageal Surgery” is edited by Ory Wiesel, MD, from Division of Thoracic Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, New York, USA.

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Vol 7, No 21 (November, 2019)

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Meet The Professor more

Dr. Zhouqiao Wu: the magic of change More >>

Dr. Dimitrios Moris: experience in article writing about academic research and social issues More >>

Prof. Bin Zhang: no pains, no gains More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary

Testing microsatellite instability in solid tumors: the ideal versus what is real

Virgilio Souza E. Silva, Louise De Brot, Rachel P. Riechelmann

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Treating BRAFV600E metastatic colorectal patients in 2019: a BEACON of hope?

Christelle de la Fouchardiere

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IMblaze 370: lessons learned and future strategies in colorectal cancer treatment

Mark McGregor, Timothy J. Price

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Resistance of the stable—towards more precise prediction of response to immune checkpoint blockade in microsatellite-unstable cancer patients

Matthias Kloor

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Original Article

An early report of a screening program for colorectal cancer in Guangzhou, China

Yujing Fang, Binyi Xiao, Jianhong Peng, Huan Tian, Fulong Wang, Lingheng Kong, Shiyong Lin, Jibin Li, Qiying Su, Kunwu Luo, Meixian Ye, Qingjian Ou, Wenhua Fan, Cong Li, Junzhong Lin, Rongxin Zhang, Wenhao Zhou, Liren Li, Gong Chen, Zhenhai Lu, Xiaojun Wu, Peirong Ding, Meichun Zheng, Xia Yang, Zhizhong Pan, Desen Wan

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The effect of biofeedback training on intestinal function among patients with middle and low rectal cancer: a randomized controlled study

Li Liu, Xiaodan Wu, Qianwen Liu, Caixing Tang, Baojia Luo, Yujing Fang, Zhizhong Pan, Desen Wan, Meichun Zheng

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Determination of follistatin-like protein 1 expression in colorectal cancer and its association with clinical outcomes

Yujie Zhao, Qingjian Ou, Yuxiang Deng, Jianhong Peng, Cong Li, Jibin Li, Qian Zhao, Miaozhen Qiu, Desen Wan, Yujing Fang, Zhizhong Pan

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Diagnostic value, safety, and histopathologic discrepancy risk factors for endoscopic forceps biopsy and transrectal ultrasound-guided core needle biopsy in rectum lesions

Min Liu, Zhen-Hai Lu, Qiao-Xuan Wang, Wei Zheng, Xiao-Qing Pei, Feng Han, Jian-Hua Zhou, Xi Lin, De-Sen Wan, An-Hua Li

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Prolonged surveillance of colorectal cancer patients after curative surgeries beyond five years of follow-up

Lingheng Kong, Jianhong Peng, Jibin Li, Fulong Wang, Cong Li, Peirong Ding, Liren Li, Gong Chen, Xiaojun Wu, Zhenhai Lu, Yujing Fang, Zhizhong Pan, Desen Wan

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Review Article

Concise update on colorectal cancer epidemiology

Camilla Mattiuzzi, Fabian Sanchis-Gomar, Giuseppe Lippi

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Circulating molecular biomarkers for screening or early diagnosis of colorectal cancer: which is ready for prime time?

Elisa Danese, Martina Montagnana, Giuseppe Lippi

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Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Primary extragenital choriocarcinoma in posterior mediastinum in a male adult: a case report

Weigang Zhao, Tangbing Chen, Yi Yang

A right atrium metastasis of breast cancer after long-term endocrine therapy

Fengrui Xu, Xiaodi Wang, Zefei Jiang

Successful use of an EZ-blocker for lung isolation and management in a hemoptysis patient

Joo Hyung Son, Do Hyung Kim, Sung Kwang Lee

Mesh-preservation approach to treatment of mesh infection after large incisional ventral hernia repair—how I do it

Xuefei Yang, Maimaiti Aihemaiti, Hao Zhang, Li Jiang, Guixi Zhang, Mali Qin, Yiheng Pan, Xiumei Wen, Fion Siu Yin Chan, Joe King Man Fan

Aortic intimal intussusception during acute type B aortic dissection endovascular repair

Zhi-Yuan Wu, Peng Li, Ji-Yang Wang, Yong-Peng Diao, Zuo-Guan Chen, Yu-Qing Miao, Zhi-Gang Chang, Hong Zhang, Yong-Jun Li

Editorial

A new peg-filgrastim biosimilar, mecapegfilgrastim for primary prophylaxis of chemotherapy-related neutropenia is now available

Umberto Tirelli, Antonino Carbone, Raffaele Di Francia, Massimiliano Berretta

TSPAN8 and distant metastasis of nasopharyngeal carcinoma cells

Changqing Xie, Nicole A. McGrath

Real-life clinical data mining: generating hypotheses for evidence-based medicine

Jean-Emmanuel Bibault

Joint forces for making clinical prediction models contribute to science

Junfeng Wang, Yue Li

Predictive analytics in the era of big data: opportunities and challenges

Zhongheng Zhang

Editorial Commentary

BRAF mutant metastatic colorectal cancers: new arrows in our quiver

Chiara Cremolini, Roberto Moretto, Gemma Zucchelli, Alfredo Falcone

Good news from the Da Qing Diabetes Prevention Outcome Study—healthy lifestyles result in long-term cardiovascular benefits

Matti Uusitupa

Radiation and cardiovascular disease

Nicolas Palaskas, Ashley Patel, Syed Wamique Yusuf

Are the long-term outcomes of percutaneous ablation for clinical stage T1 renal tumors similar to those of partial nephrectomy?

Roy Mano, A. Ari Hakimi

Management of brain metastases from renal cell carcinoma

Suguru Shirotake

A TITAN step forward: apalutamide for metastatic castration-sensitive prostate cancer

Daniel Hyuck-Min Kwon, Terence Friedlander

Non-selective beta blockers in cirrhosis: time to extend the indications?

Dev Katarey, Rajiv Jalan

Toxicity of pelvic nodal radiation for localized prostate cancer

Waqar Haque, E. Brian Butler, Bin S. Teh

Do we have a “game changer” in treating patients with brain metastasis from renal cell carcinoma?

Olga Vornicova, Gil Bar-Sela

Circulating tumour DNA in early stage colorectal cancer: can blood tell all?

Yat Hang To, Margaret Lee, Peter Gibbs, Jeanne Tie

Reducing dissemination of carbapenem-resistant Klebsiella pneumoniae

Matteo Bassetti, Daniele Roberto Giacobbe

Partial nephrectomy versus thermal ablation for clinical T1 renal tumours

Tobias Klatte, Grant D. Stewart

Transvaginal ultrasound-guided biopsy of adenomyosis

Simone Ferrero, Carolina Scala, Valerio Gaetano Vellone, Ennio Biscaldi, Fabio Barra

Single-cell RNA profiling of glomerular cells in diabetic kidney: a step forward for understanding diabetic nephropathy

María José Soler, Daniel Batlle

The volume-outcome relationship in kidney cancer: is more really better?

Brian T. Kadow, Shreyas S. Joshi, Alexander Kutikov, Elizabeth Handorf, Marc C. Smaldone, Robert G. Uzzo, Daniel M. Geynisman

Classification of solid renal tumor with oncocytic/eosinophilic cytoplasm: is hybrid oncocytic/chromophobe renal tumor a subtype of oncocytoma, chromophobe renal cell carcinoma, or a distinct tumor entity?

Shuji Mikami, Naoto Kuroda, Yoji Nagashima, Chisato Ohe, Hiroyuki Hayashi, Ryuichi Mizuno, Mototsugu Oya, Kaori Kameyama

Cytoreductive nephrectomy following treatment with anti-vascular endothelial growth factor-targeted agents: is it surgically safe?

Hideaki Miyake

Enhanced recovery after surgery pathways in thoracic surgery, do they end at discharge?

Maria Rodriguez, Maria Aymerich

Is it “hybrid” or “intermediate”?—more than just a semantic issue in oncocytic renal cell tumors

Diana Montezuma, Carmen Jerónimo, Rui Henrique

Carbapenem-resistant Klebsiella pneumoniae—impact of infection-prevention and control interventions

Isabelle Vock, Sarah Tschudin-Sutter

Nivolumab without brain radiotherapy is insufficient for the treatment of most patients with brain metastases from clear cell renal cell carcinoma

Amit K. Chowdhry, Sara J. Hardy, Michael T. Milano

The risks of converting post-hoc findings into primary outcomes in subsequent trials

Filipe B. Rodrigues, Joaquim J. Ferreira

“Early thrombus removal” in iliac-femoral deep vein thrombosis for prevention of post-thrombotic syndrome

Benilde Cosmi, Gualtiero Palareti

Is serotonin pathology a good biomarker in vivo for early Parkinson’s disease?

Celia Painous, Andres Perissinotti, Maria J. Martí

Erlotinib plus bevacizumab for EGFR-mutant advanced non-squamous non-small-cell lung cancer patients: ready for first-line?

Helen Adderley, Christoph Jakob Ackermann, Raffaele Califano

The importance of antiandrogen in prostate cancer treatment

Camille Lanz, Mostefa Bennamoun, Petr Macek, Xavier Cathelineau, Rafael Sanchez-Salas

Role of immunotherapy in metastatic renal cell cancer: past, present and future

Amos Lal, Kamal Kant Sahu, Vishal Jindal, Ajay Kumar Mishra, Ahmad Daniyal Siddiqui

More than just a screen to liberate from mechanical ventilation: treat to keep extubated?

Jie Li, J. Brady Scott, Jun Duan, Kai Liu, James B. Fink

Standard of usual care defines effectiveness of early goal directed therapy

Vikram Mukherjee, Jan Bakker

Novel approaches targeting mitochondrial fission to deplete stem-like tumor cells in prostate cancer and improve treatment outcomes

Antonino Passaniti, Arif Hussain

Paradigm shift in local consolidative therapy for oligometastatic non-small cell lung cancer: a meta-analysis

Christopher Cao, Adam Chakos, Allen Guo, John J. Park, Tajalli Saghaie, Prunella Blinman

Definitive radiation for early stage lung cancer: who is medically inoperable?

Gonzalo Varela, Nuria M. Novoa

How children’s glue fixes a decades old enigma

Michael A. Rieger

The limits of complex partial nephrectomy: are there any?

Vignesh T. Packiam, R. Houston Thompson

RBP3: a possible prognostic marker and therapeutic target in diabetic retinopathy

Dario Rusciano, Paola Bagnoli

EGFR mutations in lung cancer: not all equal in the eyes of the immune system?

Kwun M. Fong, Brett G. M. Hughes, Zarnie Lwin, Ian A. Yang

Weaning off mechanical ventilation: much less an art, but not yet a science

Paolo Navalesi, Andrea Bruni, Eugenio Garofalo, Eugenio Biamonte, Federico Longhini, Pamela Frigerio

Immune-checkpoint inhibitors and the importance of concomitant medications: focus on antibiotics

Chiara Casadei, Cristian Lolli, Alberto Farolfi

The prognostic significance of preexisting diabetes in patients with surgically treated renal cell carcinoma: the ongoing debate

Ho Won Kang, Yong-June Kim

Acute kidney injury after partial nephrectomy: transient or permanent kidney damage?—Impact on long-term renal function

Giuseppe Rosiello, Umberto Capitanio, Alessandro Larcher

The novel and critical role of von Hippel-Lindau in nephron formation

Soyoung Park, So-mi Kang, Bum-Joon Park

CA19-9 as a therapeutic target in pancreatitis

Shingo Kato, Kazufumi Honda

The SONAR study—is there a future for endothelin receptor antagonists in diabetic kidney disease?

Avivit Cahn, Simona Cernea, Itamar Raz

Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia

Yu Kurata, Tetsuhiro Tanaka, Masaomi Nangaku

Complete revascularisation in STEMI: consider the benefits but do not forget the risks!

Andreas Mitsis, Alessandro Spirito, Marco Valgimigli

Drowning in data: early responses of renal cortical collecting duct cells to lithium

John Leader, Jennifer Bedford, Robert J. Walker

Signals from SABR-COMET time to move on to phase III studies

Michael T. Milano, Amit K. Chowdhry, Joseph K. Salama, Steven J. Chmura

Video-assisted thoracic surgery lobectomy oncologically is equal to the open thoracotomy one

Marcin Zieliński

Impact of circulating tumor DNA early detection and serial monitoring in the management of stage I to III colorectal cancer

Diana Bello Roufai, François-Clément Bidard

Are we approaching a new era in the treatment of anemia of chronic kidney disease patients?

Francesco Locatelli, Lucia Del Vecchio

Synergistic clinical efficacy of niraparib in combination with pembrolizumab in patients with recurrent platinum-resistant ovarian carcinoma

Joan Tymon-Rosario, Burak Zeybek, Chanhee Han, Alessandro D. Santin

Promotion of synaptogenesis and neural circuit development by exosomes

Jun Yamada, Shozo Jinno

Mismatch repair deficiency/microsatellite instability testing as predictive immunotherapy biomarkers—possible diagnostic missteps trusting a single method

Ioanna Gazouli, George Zarkavelis, Davide Mauri, George Pentheroudakis

Gene-environment interactions determine risk for dementia: the influence of lifestyle on genetic risk for dementia

Kelley T. Patten, Pamela J. Lein

Complex renal masses: partial or no partial nephrectomy?

Riccardo Lombardo, Costantino Leonardo, Anton Zarraonandia, Andrea Tubaro, Cosimo De Nunzio

Prevention and control of intensive care unit-acquired carbapenem-resistant Klebsiella pneumoniae: need for a multimodal approach

Arta Karruli, Roberto Andini, Antonio Corcione, Emanuele Durante-Mangoni

Gut microbiome, antibiotic use, and immunotherapy responsiveness in cancer

Jarred P. Reed, Suzanne Devkota, Robert A. Figlin

Immunohistochemistry as a tool for screening rare renal cancers

Cissy Yong, Grant D. Stewart, Christian Frezza

Circulating tumor cell-based or tissue biopsy-based AR-V7 detection: which provides the greatest clinical utility?

Arpit Rao, Emmanuel S. Antonarakis

The role of immunotherapy in the management of patients with renal cell carcinoma and brain metastases

Jaleh Fallah, Manmeet S. Ahluwalia

Renal double negative T cells: unconventional cells in search of a function

Raphael A. Nemenoff, Emily K. Kleczko, Katharina Hopp

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Sugammadex in the management of myasthenic patients undergoing surgery: beyond expectations

Michele Carron, Alessandro De Cassai, Federico Linassi

Percentage of tumor-infiltrating lymphocytes after chemoradiation therapy for locally advanced esophageal squamous cell carcinoma: a biomarker for pathological response rates and cancer-specific survival?

Shawn S. Groth, Bryan M. Burt

Immunohistochemical screening for the diagnosis of succinate dehydrogenase-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma

Kiril Trpkov, Farshid Siadat

SABR-COMET: a new paradigm of care lights up the twilight of metastatic disease

Paolo Sogono, David L. Ball, Shankar Siva

Serial bipolar androgen therapy (sBAT) using cyclic supraphysiologic testosterone (STP) to treat metastatic castration-resistant prostate cancer (mCRPC)

John T. Isaacs, W. Nathaniel Brennen, Samuel R. Denmeade

Circular RNAs as diagnostic tool for renal transplant patients with acute rejection

Joseph B. Moore IV, Michael L. Merchant, Shizuka Uchida

Glycosylation alterations in acute pancreatitis and pancreatic cancer: CA19-9 expression is involved in pathogenesis and maybe targeted by therapy

Ionut Negoi, Mircea Beuran, Sorin Hostiuc, Massimo Sartelli, Alaa El-Hussuna, Enrique de-Madaria

New insights into the association between non-alcoholic fatty liver disease and atherosclerosis

Alejandro Valencia-Rodríguez, Alfonso Vera-Barajas, Beatriz Barranco-Fragoso, Deyanira Kúsulas-Delint, Xingshun Qi, Nahum Méndez-Sánchez

Does vitamin D supplementation reduce type 2 diabetes risk?

Po Sing Leung

Developing effective and efficient genomic educational tools for our diverse population

Julia Wynn, Wendy K. Chung

Use of check-point inhibitors in the treatment of progressive multifocal leukoencephalopathy

Luis Miguel Juárez-Salcedo, Samir Dalia

Restaging after chemoradiotherapy for locally advanced esophageal cancer

Ingmar L. Defize, Richard van Hillegersberg, Stella Mook, Gert J. Meijer, Steven H. Lin, Jelle P. Ruurda, Peter S. N. van Rossum

Proteomic analysis of PAX8 alterations provides new insights into its role as a master regulator of migration in high-grade serous ovarian cancer

Tania Gamberi

Liver News Column

New therapeutic options for bile acid malabsorption diarrhea

Alejandro Valencia-Rodríguez, Jorge Aquino-Matus, Alfonso Vera-Barajas, Xingshun Qi, Nahum Méndez-Sánchez

Letter to the Editor

Retinol binding protein 3 as biomarker for diabetic retinopathy

Ward Fickweiler, Lloyd P. Aiello, Jennifer K. Sun, George L. King

The value of nephrometry scoring systems in prediction of conversion to radical nephrectomy in patients scheduled for nephron-sparing surgery

Lorine Haeuser, Lisa Dahlkamp, Joachim Noldus, Florian Roghmann

Meet the Professor

Professor Prithvi Mruthyunjaya: working together to move the field forward and better help our patients

Abby Qiu, Angelia Zhou

Professor Warren Boling: please be passionate about everything you do

Anita Zhang, Crystal Yan

Professor Seema Nagpal: which one should be given the priority, radiation or drug?

Melissa Zhou, Angelia Zhou

Dong Hua: choose a hospital and concentrate on one thing

Chen Gao, Jie Dong

News

Application of the CARE guideline as reporting standard in the Annals of Translational Medicine

Editorial Office

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Ergonomic thoracic port design for video-assisted thoracoscopic minimally invasive esophagectomy and lymphadenectomy: a preliminary pilot study

Han-Yu Deng, Xi Zheng, Guha Alai, Ze-Guo Zhuo, Gang Li, Jun Luo, Yi-Dan Lin

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Net benefit of routine urine parameters for urinary tract infection screening: a decision curve analysis

Yan-Qiu Han, Lei Zhang, Jun-Rui Wang, Shang-Cheng Xu, Zhi-De Hu

An artificial intelligent platform for live cell identification and the detection of cross-contamination

Ruixin Wang, Dongni Wang, Dekai Kang, Xusen Guo, Chong Guo, Meimei Dongye, Yi Zhu, Chuan Chen, Xiayin Zhang, Erping Long, Xiaohang Wu, Zhenzhen Liu, Duoru Lin, Jinghui Wang, Kai Huang, Haotian Lin

Translational aspects of body image research for obesity-related quality of life and weight loss maintenance post-bariatric surgery

Marie L. Caltabiano

Obstetrical outcome in the third trimester after hysteroscopic adhesiolysis

Qing Feng, Bingsi Gao, Huan Huang, Jeffrey Je-Chuen Woo, Lingxiao Zou, Xingping Zhao, Chunxia Cheng, Dabao Xu

Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage

Dong Wei, Fei Gao, Zhenkun Yang, Wei Wang, Yinglun Chen, Yan Lu, Jingyu Chen

Metabolic biomarker signature for predicting the effect of neoadjuvant chemotherapy of breast cancer

Xiaojie Lin, Rui Xu, Siying Mao, Yuzhu Zhang, Yan Dai, Qianqian Guo, Xue Song, Qingling Zhang, Li Li, Qianjun Chen

Vortioxetine versus sertraline in metabolic control, distress and depression in Mexican patients with type 2 diabetes

Carlos Alfonso Tovilla-Zárate, Antonia Pérez-Mandujano, Iris Rubí Ramírez-González, Ana Fresan, Samuel Suarez-Mendez, Esteban Martínez-Villaseñor, Ester Rodríguez-Sánchez, Mario Villar-Soto, María Lilia López-Narváez, Thelma Beatriz González-Castro, Jorge L. Ble-Castillo, Isela Esther Juárez-Rojop

Can the preoperative nutritional risk score be a predictor of the outcomes in critically ill patients of lung transplantation: a retrospective study

Kongmiao Lu, Huixing Li, Yinglun Chen, Bo Wu, Ji Zhang, Man Huang, Jingyu Chen

Clinical outcomes of ceftazidime-avibactam in lung transplant recipients with infections caused by extensively drug-resistant gram-negative bacilli

Wenhui Chen, Lingxiao Sun, Lijuan Guo, Bin Cao, Yingmei Liu, Li Zhao, Binghuai Lu, Binbin Li, Jingyu Chen, Chen Wang

The value of high-resolution HLA in the perioperative period of non-sensitized lung transplant recipients

Ji Zhang, Dong Liu, Caixin Zhang, Min Zhou, Jian Lv, Hongmei Wang, Hang Yang, Li Fan, Bo Wu, Jingyu Chen

miR-3619-3p promotes papillary thyroid carcinoma progression via Wnt/β-catenin pathway

Shuang Yu, Siting Cao, Shubin Hong, Xiaorong Lin, Hongyu Guan, Shuwei Chen, Quan Zhang, Weiming Lv, Yanbing Li, Haipeng Xiao

Prognostic and clinicopathological significance of FGFR1 gene amplification in resected esophageal squamous cell carcinoma: a meta-analysis

Yan Wang, Yanming Wu, Jialong Li, Yutian Lai, Kun Zhou, Guowei Che

Cost-effectiveness analysis of comprehensive intervention programs to control blood glucose in overweight and obese type 2 diabetes mellitus patients based on a real-world setting: Markov modeling

Hui Wang, Mengyang Wang, Jiao Wang, Hongwei Liu, Rui Lu, Tongqing Duan, Xiaowen Gong, Siyuan Feng, Zhuang Cui, Yuanyuan Liu, Changping Li, Jun Ma

Development and validation of prognostic nomogram for young patients with gastric cancer

Chaoran Yu, Yujie Zhang

Investigation of the underlying hub genes and mechanisms of reperfusion injury in patients undergoing coronary artery bypass graft surgery by integrated bioinformatic analyses

Zhida Shen, Jiangting Lu, Jiejin Wei, Juanjuan Zhao, Meihui Wang, Ming Wang, Xiaohua Shen, Xue Lü, Binquan Zhou, Yanbo Zhao, Guosheng Fu

Evaluation of aniseikonia with an auto-stereoscopic smartphone

Lingzhi Zhao, Huang Wu

Positioning features of vocal, semantic, and graphemic task zones in Chinese-English bilinguals

Han Gao, Zhisheng Chen, Weixiong Zhuang, Zhihe Chen, Shaotao Tan, Xichang Lan, Shikun Lian, Xuying He

The clinical value of total plasma cell-free DNA in hepatitis B virus-related hepatocellular carcinoma

Dong Wang, Xi Hu, Guo Long, Liang Xiao, Zhi-Ming Wang, Le-Du Zhou

Based on network pharmacology to explore the molecular mechanisms of astragalus membranaceus for treating T2 diabetes mellitus

Jie Li, Yanqin Huang, Sen Zhao, Qiuyue Guo, Jie Zhou, Wenjing Han, Yunsheng Xu

Probable factors affecting clinical outcomes of internal jugular vein stenosis

Chaobo Bai, Zhongao Wang, Jingwei Guan, Kexin Jin, Jingkun Sun, Yuchuan Ding, Xunming Ji, Ran Meng

Whole-brain morphometric studies in alcohol addicts by voxelbased morphometry

Jinfeng Li, Yonghao Wang, Zhengyang Xu, Tiefang Liu, Xiao Zang, Meng Li, Lin Ma

Identification of combined T-cell and B-cell reactive Echinococcus granulosus 95 antigens for the potential development of a multi-epitope vaccine

Liang Wang, Jian Gao, Xi Lan, Hui Zhao, Xiaoqian Shang, Fengming Tian, Hao Wen, Jianbing Ding, Li Luo, Xiumin Ma

Kilohertz high-frequency alternating current blocks nerve conduction without causing nerve damage in rats

Dandan Ling, Junjie Luo, Mengying Wang, Xiaodan Cao, Xiaorui Chen, Kexin Fang, Bin Yu

Lactate dehydrogenase as a prognostic marker of renal transplant recipients with severe community-acquired pneumonia: a 10-year retrospective study

Ying Su, Min-Jie Ju, Jie-Fei Ma, Guo-Wei Tu, Hong-Yu He, Zhun-Yong Gu, Yuan-Lin Song, Jing Zhang, Zhe Luo

Decreased expression of EFCC1 and its prognostic value in lung adenocarcinoma

Liang Xia, Yunke Zhu, Chuanfen Zhang, Senyi Deng, Yulan Deng, Zhenyu Yang, Jiandong Mei, Lunxu Liu

Tumor mutational and indel burden: a systematic pan-cancer evaluation as prognostic biomarkers

Hao-Xiang Wu, Zi-Xian Wang, Qi Zhao, Dong-Liang Chen, Ming-Ming He, Lu-Ping Yang, Ying-Nan Wang, Ying Jin, Chao Ren, Hui-Yan Luo, Zhi-Qiang Wang, Feng Wang

Utilization of echocardiography during septic shock was associated with a decreased 28-day mortality: a propensity scorematched analysis of the MIMIC-III database

Peng Lan, Ting-Ting Wang, Hang-Yang Li, Ru-Shuang Yan, Wei-Chao Liao, Bu-Wen Yu, Qian-Qian Wang, Ling Lin, Kong-Han Pan, Yun-Song Yu, Jian-Cang Zhou

Osimertinib and dihydroartemisinin: a novel drug combination targeting head and neck squamous cell carcinoma

Imane Chaib, Xueting Cai, David Llige, Mariacarmela Santarpia, Eloisa Jantus-Lewintre, Martyna Filipska, Carlos Pedraz, Jean Cui, Jie Yang, Jing Miao, Rongwei Sun, Jillian Wilhelmina Paulina Bracht, Masaoki Ito, Jordi Codony-Servat, Niki Karachaliou, Andrés Aguilar, Rafael Rosell, Peng Cao

Comparison of dexmedetomidine and dexamethasone as adjuvant for ropivacaine in ultrasound-guided erector spinae plane block for video-assisted thoracoscopic lobectomy surgery: a randomized, double-blind, placebo-controlled trial

Zhixin Gao, Yimin Xiao, Qing Wang, Yuanhai Li

Ophiopogon japonicus inhibits radiation-induced pulmonary inflammation in mice

Qi-Wei Yao, Xiao-Ying Wang, Jian-Cheng Li, Jun Zhang

Effect of simultaneous pancreas-kidney transplantation on blood glucose level for patients with end-stage renal disease with type 1 and type 2 diabetes

Luhao Liu, Yunyi Xiong, Tao Zhang, Jiali Fang, Lei Zhang, Guanghui Li, Lu Xu, Xingqiang Lai, Rongxin Chen, Yuhe Guo, Guanghui Pan, Junjie Ma, Zheng Chen

Comparison of a novel handheld accelerometer-based navigation system and conventional instrument for performing distal femoral resection in total knee arthroplasty: a randomized controlled trial

Xingquan Xu, Peilai Liu, Zhenfeng Yuan, Dawei Wang, Qunshan Lu, Zhe Zhang, Qing Jiang, Dongquan Shi

Effect of Candida albicans bronchial colonization on hospital- acquired bacterial pneumonia in patients with systemic lupus erythematosus

Yuetian Yu, Jia Li, Suli Wang, Yuan Gao, Hui Shen, Liangjing Lu

Suicide among cancer patients: adolescents and young adult (AYA) versus all-age patients

Huaqiang Zhou, Wei Xian, Yaxiong Zhang, Yunpeng Yang, Wenfeng Fang, Jiaqing Liu, Jiayi Shen, Zhonghan Zhang, Shaodong Hong, Yan Huang, Li Zhang

Clinical characteristics and genetic testing of an atypical familial von Hippel-Lindauzon renal cell carcinoma

Jing Wang, Feng Qi, Ping Zhang, Zicheng Xu, Yuxiao Zheng, Hongzhou Cai, Bin Yu, Ting Xu, Xiao Li, Qing Zou

The vulnerable point of modified blumgart pancreaticojejunostomy regarding pancreatic fistula learned from 50 consecutive pancreaticoduodenectomy

Sung Geun Kim, Kwang Yeol Paik, Ji Seon Oh

Predictive factors and prognostic value of pathologic complete response of ipsilateral supraclavicular lymph nodes in breast cancer after neoadjuvant chemotherapy

Jiujun Zhu, Dechuang Jiao, Xuhui Guo, Jianghua Qiao, Youzhao Ma, Jingyang Zhang, Hui Chen, Hui Xiao, Yue Yang, Zhenduo Lu, Zhenzhen Liu

Hyperuricemia and long-term mortality in patients with acute myocardial infarction undergoing percutaneous coronary intervention

Wei Guo, Dahao Yang, Dengxuan Wu, Huixia Liu, Shiqun Chen, Jin Liu, Li Lei, Yong Liu, Lifen Rao, Li Zhang

Bone turnover markers may predict the progression of osteonecrosis of the femoral head in aged males

Zhenyu Shi, Hongting Jin, Quanwei Ding, Jun Ying, Ping-Er Wang, Peijian Tong, Bangjian He

Impact of ABO-incompatibility on hepatic artery thrombosis in living donor liver transplantation

Seong Hoon Kim, Jangho Park, Sang Jae Park

The protective effect of carbenoxolone on gap junction damage in the hippocampal CA1 area of a temporal lobe epilepsy rat model

Yi Shu, Can Zhu, Min Zeng, Qiong Zhan, Zhiping Hu, Xiaomei Wu

The homolateral simultaneous pancreas-kidney transplantation: a single-center experience in China

Lei Zhang, Zheng Chen, Xingqiang Lai, Junjie Ma, Jiali Fang, Yuhe Guo, Guanghui Li, Lu Xu, Wei Yin, Yunyi Xiong, Luhao Liu, Rongxin Chen, Li Li

Active surveillance of ventilator-associated pneumonia in the intensive care unit and establishment of the risk grading system and effect evaluation

Weiping Liu, Yueying Jiao, Huimin Xing, Yunting Hai, Haoxue Li, Kai Zhang, Yuping Zhao, Yongfang Yang, Binbin Xu, Haibo Bai, Huan Bao, Shuai Zhang, Tianhui Guo

Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson’s disease

Congcong Sun, Zhenxiang Zhao, Wenfei Yu, Mingshu Mo, Chengyuan Song, Youfeng Si, Yiming Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Sole use of dexmedetomidine for sedation and analgesia in patients undergoing endovenous thermal ablation for incompetent saphenous veins

Jin Ho Hwang, Il Soo Chang, Sang Woo Park, Won-Kyoung Kwon, Jae Joon Hwang

Tumor deposit indicates worse prognosis than metastatic lymph node in gastric cancer: a propensity score matching study

Jianan Tan, Bin Yang, Zhimeng Xu, Shengning Zhou, Zhitao Chen, Jing Huang, Han Gao, Senyou Zheng, Liqiang Wen, Fanghai Han

Review Article

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Bariatric surgery and gastroesophageal reflux disease

Darius Ashrafi, Emma Osland, Muhammed Ashraf Memon

Laparoscopic adjustable gastric banding, the past, the present and the future

Niccolò Furbetta, Rosa Cervelli, Francesco Furbetta

Sublaminar polyester bands for the correction of idiopathic and neuromuscular scoliosis

Federico Canavese, Antoine Samba

Past, present, and future in pediatric spinal surgery

Jean Dubousset

Impact of bariatric surgery on cancer risk reduction

Debora S. Bruno, Nathan A. Berger

Endoscopic intragastric balloon: a gimmick or a viable option for obesity?

Katja Susanne Claudia Gollisch, Dirk Raddatz

Standard and magnetically controlled growing rods for the treatment of early onset scoliosis

Ilkka J. Helenius

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Serial elongation derotation flexion casting in children with infantile and juvenile scoliosis

Federico Canavese, Alain Dimeglio

Adolescent idiopathic scoliosis: indications for bracing and conservative treatments

André J. Kaelin

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

The diagnostic utility of pleural markers for tuberculosis pleural effusion

Man Zhang, Dan Li, Zhi-De Hu, Yuan-Lan Huang

Progress in the treatment of infantile hemangioma

Zhao-Yang Chen, Qing-Nan Wang, Yang-Hui Zhu, Ling-Yan Zhou, Ting Xu, Zhi-Yao He, Yang Yang

China lung transplantation developing: past, present and future

Bo Wu, Chunxiao Hu, Wenhui Chen, Jianxing He, Gening Jiang, Ji Zhang, Dong Liu, Xiaoshan Li, Dong Wei, Guohui Jiao, Chen Wang, Jingyu Chen

Scoliosis surgery in adulthood: what challenges for what outcome?

Yann Philippe Charles, Yves Ntilikina

The importance of sagittal balance in adult scoliosis surgery

Jason Pui Yin Cheung

Adjuvant therapy in invasive intraductal papillary mucinous neoplasm (IPMN) of the pancreas: a systematic review

Linus Aronsson, Sofia Marinko, Daniel Ansari, Roland Andersson

Long term outcome of vertical expandable prosthetic titanium rib treatment in children with early onset scoliosis

Daniel Studer, Carol-Claudius Hasler

Pay less and spend more—the real value in healthcare procurement

Federico Pennestrì, Giuseppe Lippi, Giuseppe Banfi

Intensive management of severe acute pancreatitis

Enqiang Mao

The potential roles of stem cell-derived extracellular vesicles as a therapeutic tool

Yu-Chin Huang, Liang-Chuan Lai

Special Report

In-depth mining of clinical data: the construction of clinical prediction model with R

Zhi-Rui Zhou, Wei-Wei Wang, Yan Li, Kai-Rui Jin, Xuan-Yi Wang, Zi-Wei Wang, Yi-Shan Chen, Shao-Jia Wang, Jing Hu, Hui-Na Zhang, Po Huang, Guo-Zhen Zhao, Xing-Xing Chen, Bo Li, Tian-Song Zhang

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.