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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province and the international Inspire2Live Patient Advocates organization.

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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Preface

Overview of advances in cancer immunotherapy
Vassiliki Kotoula, George Fountzilas

Review Article

Harnessing the immune system to improve cancer therapy
Nikos E. Papaioannou, Ourania V. Beniata, Panagiotis Vitsos, Ourania Tsitsilonis, Pinelopi Samara
Neoantigen-based cancer immunotherapy
Sara Bobisse, Periklis G. Foukas, George Coukos, Alexandre Harari
Towards tumor immunodiagnostics
Helen Kourea, Vassiliki Kotoula
DNA damage, tumor mutational load and their impact on immune responses against cancer
Michalis Liontos, Ioannis Anastasiou, Aristotelis Bamias, Meletios-Athanasios Dimopoulos
The dual role of complement in cancer and its implication in anti-tumor therapy
Ioannis Kourtzelis, Stavros Rafail
Optimized tumor cryptic peptides: the basis for universal neo-antigen-like tumor vaccines
Jeanne Menez-Jamet, Catherine Gallou, Aude Rougeot, Kostas Kosmatopoulos
The European Organization for Research and Treatment of Cancer perspective on designing clinical trials with immune therapeutics
Jessica Menis, Saskia Litière, Konstantinos Tryfonidis, Vassilis Golfinopoulos
Immunotherapy in non-small cell lung cancer: the clinical impact of immune response and targeting
Giannis Mountzios, Helena Linardou, Paris Kosmidis
Melanoma immunotherapy dominates the field
Panagiotis Diamantopoulos, Helen Gogas
Immunobiology and immunotherapy in genitourinary malignancies
Marinos Tsiatas, Petros Grivas
The significance of tumor-associated immune response in molecular taxonomy, prognosis and therapy of colorectal cancer patients
Andreas Nearchou, George Pentheroudakis
Toxicity management of immunotherapy for patients with metastatic melanoma
Helena Linardou, Helen Gogas

Perspective

Future perspectives in cancer immunotherapy
Marinos Tsiatas, Giannis Mountzios, Giuseppe Curigliano

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal

Commentary

Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.





Original Article


Case Report


Letter to the Editor


Study Protocol



Systematic Review and Meta-Analysis