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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Sponsored by

Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Review Article

Establishing an evaluation mode with multiple primary outcomes based on combination of diseases and symptoms in TCM clinical trials
Jing Hu, Shuo Liu, Weihong Liu, Huina Zhang, Jing Chen, Hongcai Shang
An innovative robotic platform for magnetically-driven painless colonoscopy
Federico Bianchi, Gastone Ciuti, Anastasios Koulaouzidis, Alberto Arezzo, Danail Stoyanov, Sebastian Schostek, Calogero Maria Oddo, Arianna Menciassi, Paolo Dario
A global perspective on capsule endoscopy
Tanja Nowak

Case Report

Surgical treatment of synchronous multiple neuroendocrine lung tumours (case series): is more always better?
Jury Brandolini, Luca Bertolaccini, Alessandro Pardolesi, Piergiorgio Solli

Editorial

EGFR mutation positive non-small cell lung cancer: can we identify predictors of benefit from immune checkpoint inhibitors
Ying Wang, Peter Ellis
Eravacycline for treatment of complicated intra-abdominal infections: the fire is not ignited!
Patrick M. Honore, Herbert D. Spapen
Radiotherapy treatment strategies for squamous cell carcinoma of the cervical oesophagus: moving toward better outcomes
Pierfrancesco Franco, Francesca Arcadipane, Paolo Strignano, Renato Romagnoli, Umberto Ricardi
Treatment recommendations by clinicians in stage I non-small cell lung cancer: better work-up leads to less discussion
Jo Raskin, Annelies Janssens, Jan P. Van Meerbeeck
Towards a comprehensive framework for cell-free DNA analysis: lessons from TRACERx
Bryan C. Ulrich, Nicolas Guibert
Fasting and engineered diets as powerful tool in the medical practice: an old approach in the new era
Concetta Panebianco, Adele Potenza, Valerio Pazienza
Remote home monitoring to identify and prevent diabetic foot ulceration
P. Andrew Crisologo, Lawrence A. Lavery
The role of foot collateral vessels on angiosome-oriented revascularization
César Varela, Francisco Acín, Joaquin De Haro, Ignacio Michel
Increased cancer-specific mortality in individuals developing mental disorders after cancer diagnosis: biomedical factors versus psychosocial support
Siran M. Koroukian, Martha Sajatovic
Alectinib can replace crizotinib as standard first-line therapy for ALK-positive lung cancer
Takehiro Uemura, Toyoaki Hida
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay
Jean-Pierre Routy, Vikram Mehraj

Big-data Clinical Trial Column

Development of scoring system for risk stratification in clinical medicine: a step-by-step tutorial
Zhongheng Zhang, Haoyang Zhang, Mahesh Kumar Khanal

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal

Commentary

Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface


Editorial


Perspective


Commentary


Review Article


Original Article


Case Report


Letter to the Editor


Big-data Clinical Trial Column