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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary

The death of aspirin for primary prevention—should aspirin be changed to a prescription only medication?
Aranyak Rawal, Brandon Cave, Devarshi Ardeshna, David Hana, Uzoma N. Ibebuogu, Rami N. Khouzam
Wearable cardioverter defibrillators: dead on arrival or chance of survival?
Pooja S. Jagadish, Rami N. Khouzam

Review Article

The dilemma of aspirin resistance in obese patients
Devarshi Ardeshna, Sarthak Khare, Pooja S. Jagadish, Venugopal Bhattad, Brandon Cave, Rami N. Khouzam
From WOEST to AUGUSTUS: a review of safety and efficacy of triple versus dual antithrombotic regimens in patients with atrial fibrillation requiring percutaneous coronary intervention for acute coronary syndrome
David W. Jones, Sheharyar Minhas, Joseph J. Fierro, Devarshi Ardeshna, Aranyak Rawal, Brandon Cave, Samarth P. Shah, Rami N. Khouzam
Ticagrelor or prasugrel vs. clopidogrel in combination with anticoagulation for treatment of acute coronary syndrome in patients with atrial fibrillation
Irene Kirolos, Ikechukwu Ifedili, Miguel Maturana, Alykhan Moez Premji, Brandon Cave, Sherif Roman, David Jones, Romany Gaid, Yehoshua C. Levine, Sunil Jha, Rajesh Kabra, Rami N. Khouzam
Post-operative atrial fibrillation: should we anticoagulate?
Pooja S. Jagadish, Irene Kirolos, Sarthak Khare, Aranyak Rawal, Victor Lin, Rami N. Khouzam
Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events
Venugopal B. Bhattad, Sathvika Gaddam, Margaret A. Lassiter, Pooja S. Jagadish, Devarshi Ardeshna, Brandon Cave, Rami N. Khouzam
P2Y12 inhibitors: do they increase cancer risk?
Joseph J. Fierro, Brandon Cave, Rami N. Khouzam
Targeting ticagrelor: a novel therapy for emergency reversal
Brandon Cave, Aranyak Rawal, Devarshi Ardeshna, Uzoma N. Ibebuogu, Chittoor B. Sai-Sudhakar, Rami N. Khouzam
Current status of oral anticoagulant reversal strategies: a review
Aranyak Rawal, Devarshi Ardeshna, Sheharyar Minhas, Brandon Cave, Uzoma Ibeguogu, Rami Khouzam
Is early invasive management as ST elevation myocardial infarction warranted in de Winter’s sign?—a “peak” into the widow-maker
Joel M. Raja, Amit Nanda, Issa Pour-Ghaz, Rami N. Khouzam
After COACT trial—new perspectives for the management of non-ST elevation myocardial infarction: early versus late cardiac catheterization post cardiac arrest
Miguel A. Maturana, Charles F. Clinton, Selene Caballero-Cummings, Brandon Cave, Amal Khan, Amit Nanda, Devarshi Ardeshna, Joel Raja, Rami N. Khouzam
Barriers physicians face when referring patients to cardiac rehabilitation: a narrative review
Carol Elsakr, David A. Bulger, Sherif Roman, Irene Kirolos, Rami N. Khouzam
Action plan for improving cardiac rehabilitation-related outcomes in a university hospital based on a review of previous interventions
Carol Elsakr, Leesa Wright, Pooja S. Jagadish, David A. Bulger, Uzoma N. Ibebuogu, Rami N. Khouzam
Cardiac physiology in post myocardial infarction patients: the effect of cardiac rehabilitation programs—a systematic review and update meta-analysis
Irene Kirolos, Danny Yakoub, Fiorella Pendola, Omar Picado, Aghapy Kirolos, Yehoshua C. Levine, Sunil Jha, Rajesh Kabra, Brandon Cave, Rami N. Khouzam
Apple Watch, Wearables, and Heart Rhythm: where do we stand?
Joel M. Raja, Carol Elsakr, Sherif Roman, Brandon Cave, Issa Pour-Ghaz, Amit Nanda, Miguel Maturana, Rami N. Khouzam
CardioMEMS: where we are and where can we go?
Issa Pour-Ghaz, David Hana, Joel Raja, Uzoma N. Ibebuogu, Rami N. Khouzam
Is there an optimal “door to cath time” in the treatment of acute pulmonary embolism with catheter-directed thrombolysis?
Aranyak Rawal, Devarshi Ardeshna, Kirstin Hesterberg, Brandon Cave, Uzoma N. Ibebuogu, Rami N. Khouzam
Transcatheter aortic valve replacement with a focus on transcarotid: a review of the current literature
Issa Pour-Ghaz, Joel Raja, Mahmoud Bayoumi, Theodore Manolukas, Rami N. Khouzam, Uzoma N. Ibebuogu
Accuracy of non-invasive and minimally invasive hemodynamic monitoring: where do we stand?
Issa Pour-Ghaz, Theodore Manolukas, Nathalie Foray, Joel Raja, Aranyak Rawal, Uzoma N. Ibebuogu, Rami N. Khouzam
The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding
Abeer Ahmed Abdel Maksoud, Sherine Mohamed Sharara, Amit Nanda, Rami N. Khouzam


Cardiac technology
Pooja S. Jagadish


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Column in Laboratory Medicine

Letter to the Editor

Original Article

Review Article

Study Protocol