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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)


Hot topics in ventilator-associated pneumonia
Saad Nseir, Ignacio Martin-Loeches

Original Article

Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia
Raquel Almansa, Leonor Nogales, Marta Martín-Fernández, Montse Batlle, Esther Villareal, Lucia Rico, Alicia Ortega, Guillermo López-Campos, David Andaluz-Ojeda, Paula Ramírez, Lorenzo Socias, Luis Tamayo, Jordi Vallés, Jesús F. Bermejo-Martín, Ignacio Martín-Loeches
Impact of subglottic secretion drainage on microaspiration in critically ill patients: a prospective observational study
Guillaume Millot, Pauline Boddaert, Erika Parmentier-Decrucq, Aurore Palud, Malika Balduyck, Patrice Maboudou, Farid Zerimech, Frédéric Wallet, Sébastien Preau, Saad Nseir
Impact of hyperoxemia on mortality in critically ill patients with ventilator-associated pneumonia
Sophie Six, Anahita Rouzé, Olivier Pouly, Julien Poissy, Frédéric Wallet, Sébastien Preau, Saad Nseir

Review Article

Lung ultrasound for diagnosis and monitoring of ventilator-associated pneumonia
Bélaïd Bouhemad, Ophélie Dransart-Rayé, Francesco Mojoli, Silvia Mongodi
Is intra-abdominal hypertension a risk factor for ventilatorassociated pneumonia?
Eleni Papakrivou, Eustratios Manoulakas, Epaminondas Zakynthinos, Demosthenes Makris
“The multimodal approach for ventilator-associated pneumonia prevention”—requirements for nationwide implementation
Francisco Álvarez-Lerma, M. Sánchez-García, Task Force of Experts for Project “Zero
Are tracheal surveillance cultures useful in the intensive care unit?
Sandrine Dray, Benjamin Coiffard, Nicolas Persico, Laurent Papazian, Sami Hraiech
Subglottic secretion drainage for ventilator-associated pneumonia prevention: an underused efficient measure
Jean-Claude Lacherade, Marie-Ange Azais, Caroline Pouplet, Gwenhael Colin
New treatments of multidrug-resistant Gram-negative ventilatorassociated pneumonia
Garyphallia Poulakou, Styliani Lagou, Drosos E. Karageorgopoulos, George Dimopoulos
Ventilator-associated pneumonia related to ESBL-producing gram negative bacilli
Benoit Pilmis, Jean-Ralph Zahar
Ventilator-associated events versus ventilator-associated respiratory infections—moving into a new paradigm or merging both concepts, instead?
Sergio Ramirez-Estrada, Yolanda Peña-Lopez, Vandana Kalwaje Eshwara, Jordi Rello
Oropharyngeal colonization: epidemiology, treatment and ventilator-associated pneumonia prevention
Jonathan Messika, Béatrice La Combe, Jean-Damien Ricard
Ventilator-associated pneumonia in extracorporeal membrane oxygenation-assisted patients
Guillaume Franchineau, Charles Edouard Luyt, Alain Combes, Matthieu Schmidt


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.


Review Article

Original Article

Case Report

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