Home - Annals of Translational Medicine

Application of the CARE Guideline as reporting standing in the Annals of Translational Medicine

The Annals of Translational Medicine welcomes case reports which are supposed to report new observations of diseases, clinical findings or novel/unique treatment outcomes relevant to practitioners in the fields of medicine.

Focused Issue on Current Trends and Advancements in Spine Surgery

In this focused issue of Annals of Translational Medicine, world-renowned leaders, academics, and physicians contribute their expertise and knowledge regarding the latest cutting-edge developments in the field of spine surgery. Trends discussed in this issue include the various ways in which the changing financial aspects and models of spine surgery are affecting the care delivered to patients.

Focused Issue on Perioperative Management of Patients with Undergoing Mechanical Circulatory Support

This Focused Issue on “Perioperative Management of Patients with Undergoing Mechanical Circulatory Support” is edited by Kamen Valchanov, MD, BSc, FRCA, FFICM, from Department of Anaesthesia and Intensive Care, Royal Papworth Hospital, Cambridge, UK.

Focused Issue on 10th Annual Meeting of the Rheumatologic Dermatology Society

The 10th Annual National Meeting of the RDS was held at the Wyndham Grand Chicago Riverfront Hotel on October 20, 2018 in Chicago, Illinois, USA in conjunction with the annual national meeting of the ACR. With the authors’ permission, the Annals of Translational Medicine has kindly agreed to publish abstracts of the presentations that were given at the 2018 RDS meeting. All the meeting abstracts could be found here: http://atm.amegroups.com/issue/view/875.

Focused Issue on Cancer Metastasis: Molecular Signaling and Therapeutic

This Focused Issue on “Cancer Metastasis: Molecular Signaling and Therapeutic” is edited by Dr. Khalid Sossey-Alaoui, PhD, from Division of Cancer Biology, MetroHealth Medical Research Center, MetroHealth System, Cleveland, Ohio, USA.

Focused Issue on Structural Heart Disease: The Revolution

This focused issue on “Structural Heart Disease: The Revolution” is edited by Dr. Da-niel Hernandez-Vaquero from Cardiac Surgery Department, Heart Area, Hospital Uni-versitario Central de Asturias, Oviedo, Spain.

ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

Focused Issue: Recent Developments in Cataract Surgery

This ATM focused issue on Recent Developments in Cataract Surgery is edited by Dr. Andrzej Grzybowski, Professor of Ophthalmology, Chair of Department of Ophthalmology, University of Warmia and Mazury, Olsztyn; Head of Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland.

Focused Issue on Neurological Diseases

This focused issue on “Neurological Diseases” is edited by Dr. Wei-Hai Xu, Department of Neurology, Peking Union Medical College Hospital, Beijing, China.

Focus on “Wilson’s disease: From Genetics to Management of Disease” edited by Dr. Ralf Weiskirchen and Dr. Wolfgang Stremmel

In this focused issue “Wilson Disease: From Genetics to Management of Disease”, leading experts working in the field of Wilson disease have summarized recent findings and advances in our understanding of this copper overload disease in regard to experimental and clinical aspects. The present knowledge on genetics and pathophysiology in relation to diagnostic and therapeutic procedures is our special interest. Challenges in diagnosis, anti-copper therapies, and clinical practice guidelines will be discussed.

Focused Issue on Strategies to Achieve Long-term Success of Lung Transplantation

This focused issue on “Strategies to Achieve Long-term Success of Lung Transplantation is edited by Dr. Masaaki Sato and Dr. Dong Tian, Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Focused Issue on Stem Cell and Clinical Application

This focusedissue on “Stem Cell and Clinical Application” is edited by Dr. Ling Lu, fromDivision of Liver Surgery, the First Affiliated Hospital of Nanjing MedicalUniversity, Nanjing, China

Focused Issue on The Immature Spine

This focused issue is edited by Dr. Federico Canavese, from Department of Pediatric Orthopedic Surgery, University Hospital Estaing, 1 place Lucie et Raymond Aubrac, Clermont Ferrand 63003, France.

Focus on “Spinal Tumor Surgery” edited by Dr. Matthew L. Goodwin and Dr. Daniel M. Sciubba

This special issue of Annals of Translational Medicine focuses on tumors in and around the spine. The field of spine tumor surgery is undergoing a transition period, as multidisciplinary care of the patient with the spinal tumor has become the standard of care.

Focus on: “Application of Artificial Intelligence to Radiology” edited by Dr. Timothy Deyer and Dr. Amish Doshi

In this focused issue of the Annals of Translational Medicine “Application of Artificial Intelligence to Radiology”, we explore the use of AI in to specific clinical and operational problems in Radiology.

Focus on “Pompe Disease” edited by Dr. Rosa Puertollano and Dr. Nina Raben

In this special issue of Annals of Translational Medicine, well distinguished clinicians, academic researchers, industry scientists, and patient advocates address recent advances and challenges in current and future therapies for Pompe disease, a prototypical lysosomal storage disorder. As is the case with many maladies, the history of Pompe disease, a severe neuromuscular disorder, is a reflection of the accelerating pace of basic science discoveries and the speed with which scientific knowledge is translated into medical progress.

Focus on “Diagnostic and Therapeutic Advances in the Management of Lung Cancer” edited by Dr. Kassem Harris and Dr. Samjot Singh Dhillon

Lung cancer remains the leading cause of cancer-related mortality worldwide. The last decade has witnessed multiple encouraging advances in the diagnosis and management of patients with lung cancer. The current issue provides focused reviews contributed by experts in the field with up-to-date information on a variety of topics related to management of lung cancer in an open access format.

ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

ATM New Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that, effective June 2019, Dr. Yinghao Sun will be taking over as co-the Editor-in-Chief in tandem with Dr. Xuehao Wang and Dr. Jianxing He.

Dr. Yinghao Sun is a Chief Physician, PhD Supervisor, an Academician of the Chinese Academy of Engineering, the Chief Scientist of 973 programs, and the winner of Ho Leung Ho Lee Foundation Award. He is currently the President of the Second Military Medical University, and he is the Director of the Department of Urology. He is also the Director of the Research Institute for Prostatic Disease of the PLA, and the Director of Changhai da Vinci Robotic Surgery Training Center. Dr. Sun specializes in clinical diagnosis, treatment, and research of urological tumors and urolithiasis, as well as practice and innovate techniques for minimally invasive urological techniques.

ATM New Honorary Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that Dr. Rafael Rosell, former Editor-in-Chief of the journal, will continuously serve on the editorial board as the Honorary Editor-in-Chief from June 2019.

First of all, we would like to sincerely thank Dr. Rafael Rosell for his hard work and dedication since 2015, without which the journal would not be the success it is today.

Focus on “Lower extremity arthroplasty” edited by Dr. Nipun Sodhi, Dr. Joseph O. Ehiorobo, Dr. Hiba K. Anis, Dr. Assem A. Sultan and Dr. Michael A. Mont.

This special section of Annals of Translational Medicine focuses on lower extremity arthroplasty, especially knee and hip pathologies. In this section, a multitude of pertinent topics for orthopaedic surgeons as well as for the general patient population are reviewed.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” edited by Dr. Bo Li

Ever since an awareness of two distinct cultural conceptions of healthcare has emerged, the debate concerning whether evidence-based medicine and Traditional Chinese medicine (TCM) are incompatible or whether they can in fact be unified, has continued.

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease

In this focused issue of the Annals of Translational Medicine Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease”, multiple manuscripts in this special issue address and review recent developments in the realm of antithrombotic therapy and reversal, intervention by both invasive and non-invasive means, and current challenges.

Focused Issue on Innovations and Updates in Esophageal Surgery

This Focused Issue on “Innovations and Updates in Esophageal Surgery” is edited by Ory Wiesel, MD, from Division of Thoracic Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, New York, USA.

‹ ›

Vol 7, No 19 (October, 2019)

About atm

Manuscript Submission

AME Editing Service

Reprint & Permission

Advertising

Contact us

General editorial enquiries:
Email: editor@atmjournal.org
Copyright related contact:
Email: permissions@amegroups.com
Commercial Sales contact (Reprints, advertising, etc.):
Email: sales@amegroups.com

Meet The Professor more

Dr. Zhouqiao Wu: the magic of change More >>

Experience in article writing about academic research and social issues More >>

Prof. Bin Zhang: no pains, no gains More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

A focused issue on pediatric acute respiratory distress syndrome

Jan Hau Lee, Martin Kneyber, Ira M. Cheifetz

PDF Full Text

Review Article

Definition and global epidemiology of pediatric acute respiratory distress syndrome

Fernando Beltramo, Robinder G. Khemani

PDF Full Text

Lessons learned in acute respiratory distress syndrome from the animal laboratory

Nadir Yehya

PDF Full Text

Insights into the immuno-pathogenesis of acute respiratory distress syndrome

Judith Ju Ming Wong, Jing Yao Leong, Jan Hau Lee, Salvatore Albani, Joo Guan Yeo

PDF Full Text

Biomarkers in pediatric acute respiratory distress syndrome

Erin F. Carlton, Heidi R. Flori

PDF Full Text

Ventilator-induced lung injury in children: a reality?

Alette A. Koopman, Pauline de Jager, Robert G. T. Blokpoel, Martin C. J. Kneyber

PDF Full Text

The role of point-of-care ultrasound in pediatric acute respiratory distress syndrome: emerging evidence for its use

Samantha K. Potter, Michael J. Griksaitis

PDF Full Text

Steroids in pediatric acute respiratory distress syndrome

Nicolás Monteverde-Fernández, Federico Cristiani, Jenniffer McArthur, Sebastián González-Dambrauskas

PDF Full Text

Sedation strategies in children with pediatric acute respiratory distress syndrome (PARDS)

Lynne Rosenberg, Chani Traube

PDF Full Text

What do we know about optimal nutritional strategies in children with pediatric acute respiratory distress syndrome?

Rajalakshmi Iyer, Arun Bansal

PDF Full Text

Transfusion in children with acute respiratory distress syndrome

Tine François, Guillaume Emeriaud, Oliver Karam, Marisa Tucci

PDF Full Text

Extra-corporeal membrane oxygenation in paediatric acute respiratory distress syndrome: overrated or underutilized?

Simon Erickson

PDF Full Text

Pertinent clinical outcomes in pediatric survivors of pediatric acute respiratory distress syndrome (PARDS): a narrative review

Siew Wah Lee, Sin Wee Loh, Chengsi Ong, Jan Hau Lee

PDF Full Text

Clinical trials and future directions in pediatric acute respiratory distress syndrome

Veerajalandhar Allareddy, Ira M. Cheifetz

PDF Full Text

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Big-data Clinical Trial Column

Binary logistic regression modeling with TensorFlow™

Zhongheng Zhang, Lei Mo, Chen Huang, Ping Xu, written on behalf of AME Big-Data Clinical Trial Collaborative Group

Case Report

Primary extragenital choriocarcinoma in posterior mediastinum in a male adult: a case report

Weigang Zhao, Tangbing Chen, Yi Yang

Bronchoesophageal fistula secondary to postpneumonectomy like syndrome caused by bilobectomy and postoperative radiation therapy for lung cancer

Hee Yun Seol, Taehwa Kim, Sung Kwang Lee, Joo Hyung Son, Do Hyung Kim

A right atrium metastasis of breast cancer after long-term endocrine therapy

Fengrui Xu, Xiaodi Wang, Zefei Jiang

Editorial

Nanotechnology as a savior in asthma management

Chin Kook Rhee

Editorial for focused issue “Cancer Health and Medicine: A new era”

Santanu Dasgupta

Nanotechnology bring a new hope for asthmatics

Wen-Chien Cheng, Chia-Hung Chen

Expert Consensus

Expert consensus on spontaneous ventilation video-assisted thoracoscopic surgery in primary spontaneous pneumothorax (Guangzhou)

Jianxing He, Jun Liu, Chengchu Zhu, Tianyang Dai, Kaican Cai, Zhifeng Zhang, Chao Cheng, Kun Qiao, Xiang Liu, Guangsuo Wang, Shun Xu, Rusong Yang, Junqiang Fan, Hecheng Li, Jiang Jin, Qinglong Dong, Lixia Liang, Jinfeng Ding, Kaiming He, Yulin Liu, Jing Ye, Siyang Feng, Yu Jiang, Haoda Huang, Huankai Zhang, Zhenguo Liu, Xia Feng, Zhaohua Xia, Mingfei Ma, Zhongxin Duan, Tonghai Huang, Yali Li, Qiming Shen, Wenfei Tan, Hong Ma, Yang Sun, Congcong Chen, Fei Cui, Wei Wang, Jingpei Li, Zhexue Hao, Hui Liu, Wenhua Liang, Xusen Zou, Hengrui Liang, Hanyu Yang, Yingfen Li, Shunjun Jiang, Calvin S. H. Ng, Diego González-Rivas, Eugenio Pompeo, Raja M. Flores, Yaron Shargall, Mahmoud Ismail, Benedetta Bedetti, Ahmed G. Elkhouly, Keng Ang

Editorial Commentary

BRAF mutant metastatic colorectal cancers: new arrows in our quiver

Chiara Cremolini, Roberto Moretto, Gemma Zucchelli, Alfredo Falcone

Treating BRAFV600E metastatic colorectal patients in 2019: a BEACON of hope?

Christelle de la Fouchardiere

Good news from the Da Qing Diabetes Prevention Outcome Study—healthy lifestyles result in long-term cardiovascular benefits

Matti Uusitupa

Radiation and cardiovascular disease

Nicolas Palaskas, Ashley Patel, Syed Wamique Yusuf

Are the long-term outcomes of percutaneous ablation for clinical stage T1 renal tumors similar to those of partial nephrectomy?

Roy Mano, A. Ari Hakimi

Management of brain metastases from renal cell carcinoma

Suguru Shirotake

A TITAN step forward: apalutamide for metastatic castration-sensitive prostate cancer

Daniel Hyuck-Min Kwon, Terence Friedlander

Non-selective beta blockers in cirrhosis: time to extend the indications?

Dev Katarey, Rajiv Jalan

Toxicity of pelvic nodal radiation for localized prostate cancer

Waqar Haque, E. Brian Butler, Bin S. Teh

IMblaze 370: lessons learned and future strategies in colorectal cancer treatment

Mark McGregor, Timothy J. Price

Do we have a “game changer” in treating patients with brain metastasis from renal cell carcinoma?

Olga Vornicova, Gil Bar-Sela

Circulating tumour DNA in early stage colorectal cancer: can blood tell all?

Yat Hang To, Margaret Lee, Peter Gibbs, Jeanne Tie

Reducing dissemination of carbapenem-resistant Klebsiella pneumoniae

Matteo Bassetti, Daniele Roberto Giacobbe

Partial nephrectomy versus thermal ablation for clinical T1 renal tumours

Tobias Klatte, Grant D. Stewart

Transvaginal ultrasound-guided biopsy of adenomyosis

Simone Ferrero, Carolina Scala, Valerio Gaetano Vellone, Ennio Biscaldi, Fabio Barra

Single-cell RNA profiling of glomerular cells in diabetic kidney: a step forward for understanding diabetic nephropathy

María José Soler, Daniel Batlle

The volume-outcome relationship in kidney cancer: is more really better?

Brian T. Kadow, Shreyas S. Joshi, Alexander Kutikov, Elizabeth Handorf, Marc C. Smaldone, Robert G. Uzzo, Daniel M. Geynisman

Classification of solid renal tumor with oncocytic/eosinophilic cytoplasm: is hybrid oncocytic/chromophobe renal tumor a subtype of oncocytoma, chromophobe renal cell carcinoma, or a distinct tumor entity?

Shuji Mikami, Naoto Kuroda, Yoji Nagashima, Chisato Ohe, Hiroyuki Hayashi, Ryuichi Mizuno, Mototsugu Oya, Kaori Kameyama

Cytoreductive nephrectomy following treatment with anti-vascular endothelial growth factor-targeted agents: is it surgically safe?

Hideaki Miyake

Enhanced recovery after surgery pathways in thoracic surgery, do they end at discharge?

Maria Rodriguez, Maria Aymerich

Is it “hybrid” or “intermediate”?—more than just a semantic issue in oncocytic renal cell tumors

Diana Montezuma, Carmen Jerónimo, Rui Henrique

Carbapenem-resistant Klebsiella pneumoniae—impact of infection-prevention and control interventions

Isabelle Vock, Sarah Tschudin-Sutter

Nivolumab without brain radiotherapy is insufficient for the treatment of most patients with brain metastases from clear cell renal cell carcinoma

Amit K. Chowdhry, Sara J. Hardy, Michael T. Milano

How will nanotechnology lead to better control of asthma?

Bumhee Yang, Hayoung Choi, Sang-Heon Kim, Ho Joo Yoon, Hyun Lee

The risks of converting post-hoc findings into primary outcomes in subsequent trials

Filipe B. Rodrigues, Joaquim J. Ferreira

“Early thrombus removal” in iliac-femoral deep vein thrombosis for prevention of post-thrombotic syndrome

Benilde Cosmi, Gualtiero Palareti

Is serotonin pathology a good biomarker in vivo for early Parkinson’s disease?

Celia Painous, Andres Perissinotti, Maria J. Martí

Erlotinib plus bevacizumab for EGFR-mutant advanced non-squamous non-small-cell lung cancer patients: ready for first-line?

Helen Adderley, Christoph Jakob Ackermann, Raffaele Califano

The importance of antiandrogen in prostate cancer treatment

Camille Lanz, Mostefa Bennamoun, Petr Macek, Xavier Cathelineau, Rafael Sanchez-Salas

Role of immunotherapy in metastatic renal cell cancer: past, present and future

Amos Lal, Kamal Kant Sahu, Vishal Jindal, Ajay Kumar Mishra, Ahmad Daniyal Siddiqui

More than just a screen to liberate from mechanical ventilation: treat to keep extubated?

Jie Li, J. Brady Scott, Jun Duan, Kai Liu, James B. Fink

Standard of usual care defines effectiveness of early goal directed therapy

Vikram Mukherjee, Jan Bakker

Novel approaches targeting mitochondrial fission to deplete stem-like tumor cells in prostate cancer and improve treatment outcomes

Antonino Passaniti, Arif Hussain

Paradigm shift in local consolidative therapy for oligometastatic non-small cell lung cancer: a meta-analysis

Christopher Cao, Adam Chakos, Allen Guo, John J. Park, Tajalli Saghaie, Prunella Blinman

Definitive radiation for early stage lung cancer: who is medically inoperable?

Gonzalo Varela, Nuria M. Novoa

How children’s glue fixes a decades old enigma

Michael A. Rieger

The limits of complex partial nephrectomy: are there any?

Vignesh T. Packiam, R. Houston Thompson

RBP3: a possible prognostic marker and therapeutic target in diabetic retinopathy

Dario Rusciano, Paola Bagnoli

EGFR mutations in lung cancer: not all equal in the eyes of the immune system?

Kwun M. Fong, Brett G. M. Hughes, Zarnie Lwin, Ian A. Yang

Weaning off mechanical ventilation: much less an art, but not yet a science

Paolo Navalesi, Andrea Bruni, Eugenio Garofalo, Eugenio Biamonte, Federico Longhini, Pamela Frigerio

Immune-checkpoint inhibitors and the importance of concomitant medications: focus on antibiotics

Chiara Casadei, Cristian Lolli, Alberto Farolfi

The prognostic significance of preexisting diabetes in patients with surgically treated renal cell carcinoma: the ongoing debate

Ho Won Kang, Yong-June Kim

Acute kidney injury after partial nephrectomy: transient or permanent kidney damage?—Impact on long-term renal function

Giuseppe Rosiello, Umberto Capitanio, Alessandro Larcher

The novel and critical role of von Hippel-Lindau in nephron formation

Soyoung Park, So-mi Kang, Bum-Joon Park

CA19-9 as a therapeutic target in pancreatitis

Shingo Kato, Kazufumi Honda

The SONAR study—is there a future for endothelin receptor antagonists in diabetic kidney disease?

Avivit Cahn, Simona Cernea, Itamar Raz

Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia

Yu Kurata, Tetsuhiro Tanaka, Masaomi Nangaku

Complete revascularisation in STEMI: consider the benefits but do not forget the risks!

Andreas Mitsis, Alessandro Spirito, Marco Valgimigli

Drowning in data: early responses of renal cortical collecting duct cells to lithium

John Leader, Jennifer Bedford, Robert J. Walker

Signals from SABR-COMET time to move on to phase III studies

Michael T. Milano, Amit K. Chowdhry, Joseph K. Salama, Steven J. Chmura

iMDT Corner

Conversion therapy from N3 unresectable lung adenocarcinoma to radical surgery: a case report

Huali Hu, Shuai Zou, Ruofu Xu, Yoshinobu Ichiki, Dirk De Ruysscher, Fenglei Yu, Aihui Liao

Liver News Column

New therapeutic options for bile acid malabsorption diarrhea

Alejandro Valencia-Rodríguez, Jorge Aquino-Matus, Alfonso Vera-Barajas, Xingshun Qi, Nahum Méndez-Sánchez

Letter to the Editor

Critical appraisal of ENGAGES: cognitive dissonance and anesthesia research

Troy S. Wildes, Michael S. Avidan

Initiation of renal replacement therapy in patients with septic acute kidney injury: right timing or right patient?

Saber Davide Barbar, Auguste Dargent, Jean-Pierre Quenot

Indications for contrast enhanced computed tomography in patients with sepsis induced acute kidney injury

Xinxin Chen

Expanding the knowledge on development of CAKUT: molecular genetics and beyond

Gabriel C. Dworschak, Heiko Reutter, Alina C. Hilger

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Astym^® therapy improves FOTO^® outcomes for patients with musculoskeletal disorders: an observational study

Leah S. Harris, Suzanne Freeman, Ying-Chih Wang

The effect of extension assist orthosis with pneumatic bladders on pain and function for patients with early knee osteoarthritis

Kathleen Madara, Moiyad Aljehani, Federico Pozzi, Elizabeth Colonna, Joseph A. Zeni Jr

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Non-operative treatment options for knee osteoarthritis

Michael DeRogatis, Hiba K. Anis, Nipun Sodhi, Joseph O. Ehiorobo, Morad Chughtai, Anil Bhave, Michael A. Mont

Ergonomic thoracic port design for video-assisted thoracoscopic minimally invasive esophagectomy and lymphadenectomy: a preliminary pilot study

Han-Yu Deng, Xi Zheng, Guha Alai, Ze-Guo Zhuo, Gang Li, Jun Luo, Yi-Dan Lin

Performance of modified carbapenem inactivation method and inhibitor-based combined disk test in the detection and distinguishing of carbapenemase producing Enterobacteriaceae

Juan Li, Congrong Li, Xuan Cai, Jinling Shi, Lina Feng, Kewen Tang, Yongqing Tong, Yan Li

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Diagnostic value, safety, and histopathologic discrepancy risk factors for endoscopic forceps biopsy and transrectal ultrasound-guided core needle biopsy in rectum lesions

Min Liu, Zhen Hai Lu, Qiao Xuan Wang, Wei Zheng, Xiao Qing Pei, Feng Han, Jian Hua Zhou, Xi Lin, De Sen Wan, An-Hua Li

Pre-treatment systemic immune-inflammation represents a prognostic factor in patients with advanced non-small cell lung cancer

Rossana Berardi, Matteo Santoni, Silvia Rinaldi, Marc Bower, Michela Tiberi, Francesca Morgese, Miriam Caramanti, Agnese Savini, Consuelo Ferrini, Mariangela Torniai, Ilaria Fiordoliva, Thomas Newsom-Davis

Effects of medial support screws on locking plating of proximal humerus fractures in elderly patients: a retrospective study

Pengcheng Shen, Yu Zhu, Lifan Zhu, Xiaolin Li, Yaozeng Xu

Net benefit of routine urine parameters for urinary tract infection screening: a decision curve analysis

Yan-Qiu Han, Lei Zhang, Jun-Rui Wang, Shang-Cheng Xu, Zhi-De Hu

Clinical significance of the immune cell landscape in hepatocellular carcinoma patients with different degrees of fibrosis

Xiaofeng Tang, Zheyue Shu, Weichen Zhang, Longyu Cheng, Jun Yu, Min Zhang, Shusen Zheng

An artificial intelligent platform for live cell identification and the detection of cross-contamination

Ruixin Wang, Dongni Wang, Dekai Kang, Xusen Guo, Chong Guo, Meimei Dongye, Yi Zhu, Chuan Chen, Xiayin Zhang, Erping Long, Xiaohang Wu, Zhenzhen Liu, Duoru Lin, Jinghui Wang, Kai Huang, Haotian Lin

Determination of follistatin-like protein 1 expression in colorectal cancer and its association with clinical outcomes

Yujie Zhao, Qingjian Ou, Yuxiang Deng, Jianhong Peng, Cong Li, Jibin Li, Qian Zhao, Miaozhen Qiu, Desen Wan, Yujing Fang, Zhizhong Pan

Additional effect of neuromuscular electrical stimulation on knee extension lag, pain and knee range of motion in immediate postsurgical phase (0–2 weeks) in primary total knee arthroplasty patient

Rachana Dabadghav, Amruta Potdar, Vishakha Patil, Parag Sancheti, Ashok Shyam

Antidepressant-like effects of the Guanxin Danshen formula via mediation of the CaMK II-CREB-BDNF signalling pathway in chronic unpredictable mild stress-induced depressive rats

Weijie Xie, Xiangbao Meng, Yadong Zhai, Tianyuan Ye, Ping Zhou, Fengwei Nan, Guibo Sun, Xiaobo Sun

Achyranthes bidentata polypeptide k suppresses neuroinflammation in BV2 microglia through Nrf2-dependent mechanism

Qiong Cheng, Yuntian Shen, Zhenghui Cheng, Qian Shao, Caiping Wang, Hualin Sun, Qi Zhang

The effect of biofeedback training on intestinal function among patients with middle and low rectal cancer: a randomized controlled study

Li Liu, Xiaodan Wu, Qianwen Liu, Caixing Tang, Baojia Luo, Yujing Fang, Zhizhong Pan, Desen Wan, Meichun Zheng

Translational aspects of body image research for obesity-related quality of life and weight loss maintenance post-bariatric surgery

Marie L. Caltabiano

Variations in gut microbial profiles in ankylosing spondylitis: disease phenotype-related dysbiosis

Zena Chen, Jun Qi, Qiujing Wei, Xuqi Zheng, Xinyu Wu, Xiaomin Li, Zetao Liao, Zhiming Lin, Jieruo Gu

Detection of deteriorating patients after Whipple surgery by a modified early warning score (MEWS)

Min Yu, Bowen Huang, Peizhen Liu, Aimei Wang, Wenliang Ding, Yanyun Zhai, Yaqi Huang, Yuexiu Zhong, Zhixiang Jian, Huigen Huang, Baohua Hou, Dailan Xiong

Analysis of lncRNA-mRNA expression pattern in male textile workers with noise-induced hearing loss

Ning Wang, Xin Liu, Lu Ding, Enmin Ding, Baoli Zhu

Preoperative 3D-CT bronchography and angiography facilitates single-direction uniportal thoracoscopic anatomic lobectomy

Miao Zhang, Dong Liu, Wenbin Wu, Hui Zhang, Ning Mao

Lymphadenectomy is associated with poor survival in patients with gastrointestinal stromal tumors

Cong Li, Dongfang Su, Chuanbo Xie, Qichen Chen, Jianguo Zhou, Xiaojun Wu

The safety and feasibility of a single incision in simultaneous resection for patients with colorectal cancer liver metastases

Xiao Chen, Shida Yan, Hong Zhao, Yefan Zhang, Zhen Huang, Jianjun Zhao, Jianguo Zhou, Zhiyu Li, Xinyu Bi, Jianqiang Cai

Rapid and sensitive detection of Shigella flexneri using fluorescent microspheres as label for immunochromatographic test strip

Ying Chen, Linyan Zhang, Xinjian Guo, Huan Yang, Linlin Zhuang, Ying Li, Zhenzhen Wang, Bing Gu

An early report of a screening program for colorectal cancer in Guangzhou, China

Yujing Fang, Binyi Xiao, Jianhong Peng, Huan Tian, Fulong Wang, Lingheng Kong, Shiyong Lin, Jibin Li, Qiying Su, Kunwu Luo, Meixian Ye, Qingjian Ou, Wenhua Fan, Cong Li, Junzhong Lin, Rongxin Zhang, Wenhao Zhou, Liren Li, Gong Chen, Zhenhai Lu, Xiaojun Wu, Peirong Ding, Meichun Zheng, Xia Yang, Zhizhong Pan, Desen Wan

Chemoradiotherapy is associated with improved survival for resected pancreatic adenosquamous carcinoma: a retrospective cohort study from the SEER database

Yuan Fang, Ning Pu, Lei Zhang, Wenchuan Wu, Wenhui Lou

Comparative study between local anesthesia and general anesthesia in the treatment of primary spontaneous pneumothorax

Joonho Jung, Do Hyung Kim, Joohyung Son, Sung Kwang Lee, Bong Soo Son

Heat shock cognate protein 70 promotes the differentiation of C2C12 myoblast and targets Yin Yang 1

Lei Chen, Tao Guo, Yan Yu, Yeqing Sun, Guangrong Yu, Liming Cheng

Time-restricted feeding during childhood has persistent effects on mice commensal microbiota

Dandan Hu, Yuqian Ye, Yilei Mao, Wenjun Liao, Wei Xu

Prognostic nomogram integrated baseline serum lipids for patients with non-esophageal squamous cell carcinoma

Shulin Chen, Xiaohui Li, Xiaoyan Wen, Songguo Peng, Ning Xue, Shan Xing, Yijun Liu

Clinical prognostic value of isocitrate dehydrogenase mutation, O-6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in glioma patients

Xi Chen, Yuanliang Yan, Jianhua Zhou, Lei Huo, Long Qian, Shuangshuang Zeng, Zhi Li, Jie Wei, Zhijie Xu, Zhicheng Gong

Obstetrical outcome in the third trimester after hysteroscopic adhesiolysis

Qing Feng, Bingsi Gao, Huan Huang, Jeffrey Je-Chuen Woo, Lingxiao Zou, Xingping Zhao, Chunxia Cheng, Dabao Xu

Inhibition of human cervical cancer cell invasion by IL-37 involving runt related transcription factor 2 suppression

Ping Ouyang, Kun Wu, Liudan Su, Weifang An, Yanhong Bie, He Zhang, Haixian Kang, Enping Jiang, Wei Zhu, Yunhong Yao, Xinrong Hu, Zhangquan Chen, Sen Wang

Application of endobronchial ultrasonography using a guide sheath and electromagnetic navigation bronchoscopy in the diagnosis of atypical bacteriologically-negative pulmonary tuberculosis

Ye Gu, Chunyan Wu, Fangyou Yu, Xuwei Gui, Jun Ma, Liping Cheng, Qin Sun, Wei Sha

Association between TIM-3 polymorphisms and cancer risk: a meta-analysis

Hongyan Fang, Cheng Yuan, Xinsheng Gu, Qiuju Chen, Dong Huang, Heng Li, Min Sun

Value of computed tomography evaluation in pathologic classification and prognosis prediction of gastric neuroendocrine tumors

Shida Yan, Tongtong Liu, Ying Li, Yongjian Zhu, Jun Jiang, Liming Jiang, Hong Zhao

Survival and analysis of prognostic factors for hepatoblastoma: based on SEER database

Tie-Cheng Feng, Hong-Yan Zai, Wei Jiang, Qin Zhu, Bo Jiang, Lei Yao, Xin-Ying Li, Zhi-Ming Wang

Potential of the glasses-free three-dimensional display system in shortening the learning curve of video-assisted endoscopic surgery: a self-controlled ex-vivo study

Jun Liu, Jingpei Li, Wei Wei, Zhexue Hao, Hengrui Liang, Fei Cui, Wei Wang, Jun Huang, Guilin Peng, Weizhe Huang, Yidong Wang, Fengling Lai, Kaiming He, Qi Pan, Ke Xu, Weipeng Cai, Lindsey Hamblin, Wenhua Liang, Jianxing He

Review Article

Innovations in functional and rehabilitative knee bracing

Jim Hewlett, John Kenney

Evidence based treatment options for common knee injuries in runners

Simeon Mellinger, Grace Anne Neurohr

Immunotherapy and targeted therapy—the new roadmap in cancer treatment

Kamran Shahid, Mustafa Khalife, Raetasha Dabney, Alexandria Phan

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Static progressive stretch orthosis—consensus modality to treat knee stiffness—rationale and literature review

Anil Bhave, Nipun Sodhi, Hiba K. Anis, Joseph O. Ehiorobo, Michael A. Mont

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Concise update on colorectal cancer epidemiology

Camilla Mattiuzzi, Fabian Sanchis-Gomar, Giuseppe Lippi

Red flag rules for knee and lower leg differential diagnosis

Young Jae Kim

Mitochondrion: I am more than a fuel server

Santanu Dasgupta

Rehabilitation protocols following total knee arthroplasty: a review of study designs and outcome measures

Iciar M. Dávila Castrodad, Thea M. Recai, Megha M. Abraham, Jennifer I. Etcheson, Nequesha S. Mohamed, Armin Edalatpour, Ronald E. Delanois

Current criteria for return to play after anterior cruciate ligament reconstruction: an evidence-based literature review

Kala Y. Flagg, Spiridon G. Karavatas, Sam Thompson Jr, Craig Bennett

The finer scale of consciousness: quantum theory

Tianwen Li, Hailiang Tang, Jianhong Zhu, John H. Zhang

Bariatric surgery and gastroesophageal reflux disease

Darius Ashrafi, Emma Osland, Muhammed Ashraf Memon

Laparoscopic adjustable gastric banding, the past, the present and the future

Niccolò Furbetta, Rosa Cervelli, Francesco Furbetta

Circulating molecular biomarkers for screening or early diagnosis of colorectal cancer: which is ready for prime time?

Elisa Danese, Martina Montagnana, Giuseppe Lippi

Sublaminar polyester bands for the correction of idiopathic and neuromuscular scoliosis

Federico Canavese, Antoine Samba

Portal pressure monitoring—state-of-the-art and future perspective

Gang Xu, Fei Li, Yilei Mao

Past, present, and future in pediatric spinal surgery

Jean Dubousset

Impact of bariatric surgery on cancer risk reduction

Debora S. Bruno, Nathan A. Berger

Cerebral protection devices for transcatheter aortic valve replacement

Hector Cubero-Gallego, Isaac Pascual, José Rozado, Ana Ayesta, Daniel Hernandez-Vaquero, Rocio Diaz, Alberto Alperi, Pablo Avanzas, Cesar Moris

The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype?

Cristiano Fava, Filippo Cattazzo, Zhi-De Hu, Giuseppe Lippi, Martina Montagnana

Endoscopic intragastric balloon: a gimmick or a viable option for obesity?

Katja Susanne Claudia Gollisch, Dirk Raddatz

Standard and magnetically controlled growing rods for the treatment of early onset scoliosis

Ilkka J. Helenius

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Serial elongation derotation flexion casting in children with infantile and juvenile scoliosis

Federico Canavese, Alain Dimeglio

Magnesium and liver disease

Meixi Liu, Huayu Yang, Yilei Mao

Effect of type 2 diabetes medications on fracture risk

Cristian Guja, Loreta Guja, Rucsandra Dănciulescu Miulescu

Three-dimensional printing in structural heart disease and intervention

Yiting Fan, Randolph H. L. Wong, Alex Pui-Wai Lee

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Adolescent idiopathic scoliosis: indications for bracing and conservative treatments

André J. Kaelin

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Study Protocol

Efficacy and safety of Sijunzi Decoction for chronic fatigue syndrome with spleen deficiency pattern: study protocol for a randomized, double-blind, placebo-controlled trial

Liang Dai, Wen-Jun Zhou, Miao Wang, Shi-Gao Zhou, Guang Ji

Special Report

In-depth mining of clinical data: the construction of clinical prediction model with R

Zhi-Rui Zhou, Wei-Wei Wang, Yan Li, Kai-Rui Jin, Xuan-Yi Wang, Zi-Wei Wang, Yi-Shan Chen, Shao-Jia Wang, Jing Hu, Hui-Na Zhang, Po Huang, Guo-Zhen Zhao, Xing-Xing Chen, Bo Li, Tian-Song Zhang

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.