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ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

Focused Issue on Bariatirc Surgery

This focused issue on “Bariatirc Surgery” is edited by Dr. Muhammed Ashraf Memon from Sunnybank Obesity Centre and South East Queensland Surgery (SEQS), Australia.

Focused Issue on Current Trends and Advancements in Spine Surgery

This focused isuse on “Current Trends and Advancements in Spine Surgery” is edited by Dr. Kern Singh, from Department of Orthopaedic Surgery, Rush University Medical Center, Co-Director Minimally Invasive Spine Institute, USA

Focused Issue on Strategies to Achieve Long-term Success of Lung Transplantation

This focused issue on “Strategies to Achieve Long-term Success of Lung Transplantation is edited by Dr. Masaaki Sato and Dr. Dong Tian, Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Focused Issue on Stem Cell and Clinical Application

This focusedissue on “Stem Cell and Clinical Application” is edited by Dr. Ling Lu, fromDivision of Liver Surgery, the First Affiliated Hospital of Nanjing MedicalUniversity, Nanjing, China

Focused Issue on The Immature Spine

This focused issue is edited by Dr. Federico Canavese, from Department of Pediatric Orthopedic Surgery, University Hospital Estaing, 1 place Lucie et Raymond Aubrac, Clermont Ferrand 63003, France.

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease

This focused issue on “Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease” is edited by Dr. Rami Khouzam, Professor of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

ATM New Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that, effective June 2019, Dr. Yinghao Sun will be taking over as co-the Editor-in-Chief in tandem with Dr. Xuehao Wang and Dr. Jianxing He.

Dr. Yinghao Sun is a Chief Physician, PhD Supervisor, an Academician of the Chinese Academy of Engineering, the Chief Scientist of 973 programs, and the winner of Ho Leung Ho Lee Foundation Award. He is currently the President of the Second Military Medical University, and he is the Director of the Department of Urology. He is also the Director of the Research Institute for Prostatic Disease of the PLA, and the Director of Changhai da Vinci Robotic Surgery Training Center. Dr. Sun specializes in clinical diagnosis, treatment, and research of urological tumors and urolithiasis, as well as practice and innovate techniques for minimally invasive urological techniques.

ATM New Honorary Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that Dr. Rafael Rosell, former Editor-in-Chief of the journal, will continuously serve on the editorial board as the Honorary Editor-in-Chief from June 2019.

First of all, we would like to sincerely thank Dr. Rafael Rosell for his hard work and dedication since 2015, without which the journal would not be the success it is today.

Focus on “Inborn Errors of Metabolism” edited by Dr. Shibani Kanungo and Dr. Dilip R. Patel

Annals of Translation Medicine (ATM) focused issue: inborn errors of metabolism (IEM) is a one stop resource for all levels of learners from undergraduates interested in science to multiple subspecialties in the field of medicine, genetics and public health.

Reading Companion: Blooming Flowers -A call for paper

Parent's Comments: Huilongwo was built in the Qing Dynasty. It is now a historic and cultural district in Xuzhou, in the center of the city. The old building in the painting is a corner of Huilongwo. Generally, children’s life experience lacks deeper nuances to understand the historical implications of architecture, in this painting, you can still see traces of tranquillity and vicissitudes. The usage of colors in this gives the old building vitality.

Focus on “Novel Aspects in Ventilator-associated Pneumonia” edited by Dr. Saad Nseir and Dr. Ignacio Martin-Loeches

Ventilator-associated pneumonia (VAP) remains an important clinical problem, being associated with significant morbidity and mortality. In this special issue of Annals of Translational Medicine, novel aspects regarding definition, diagnosis, epidemiology, and treatment of VAP are discussed by experts in this field.

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Focus on “Lower extremity arthroplasty” edited by Dr. Nipun Sodhi, Dr. Joseph O. Ehiorobo, Dr. Hiba K. Anis, Dr. Assem A. Sultan and Dr. Michael A. Mont.

This special section of Annals of Translational Medicine focuses on lower extremity arthroplasty, especially knee and hip pathologies. In this section, a multitude of pertinent topics for orthopaedic surgeons as well as for the general patient population are reviewed.

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” edited by Dr. Bo Li

Ever since an awareness of two distinct cultural conceptions of healthcare has emerged, the debate concerning whether evidence-based medicine and Traditional Chinese medicine (TCM) are incompatible or whether they can in fact be unified, has continued.

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Vol 7, No 13 (July, 2019)

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Focused Issues (Published) more

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” More >>

Focus on “Lower extremity arthroplasty” More >>

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” More >>

Focused Issues (Ongoing) more

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge... More >>

Focused Issue on The Immature Spine More >>

Focused Issue on Stem Cell and Clinical Application More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Preface

Editorial for focused issue “Pompe disease: from basics to current and emerging therapies”

Rosa Puertollano, Nina Raben

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Original Article

Variable clinical features and genotype-phenotype correlations in 18 patients with late-onset Pompe disease

Jousef Alandy-dy, Marie Wencel, Kathy Hall, Julie Simon, Yanjun Chen, Erik Valenti, Jade Yang, Deeksha Bali, Anita Lakatos, Namita Goyal, Tahseen Mozaffar, Virginia Kimonis

PDF Full Text

Assessing metabolic profiles in human myoblasts from patients with late-onset Pompe disease

Peter Meinke, Sarah Limmer, Stefan Hintze, Benedikt Schoser

PDF Full Text

Review Article

Molecular genetics of Pompe disease: a comprehensive overview

Paolo Peruzzo, Eleonora Pavan, Andrea Dardis

PDF Full Text

Pros and cons of different ways to address dysfunctional autophagy in Pompe disease

Jeong-A Lim, Naresh Kumar Meena, Nina Raben

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Restoring the regenerative balance in neuromuscular disorders: satellite cell activation as therapeutic target in Pompe disease

Gerben J. Schaaf, Rodrigo Canibano-Fraile, Tom J. M. van Gestel, Ans T. van der Ploeg, W. W. M. Pim Pijnappel

PDF Full Text

Newborn screening: Taiwanese experience

Yin-Hsiu Chien, Wuh-Liang Hwu, Ni-Chung Lee

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Nutrition and exercise in Pompe disease

Mark A. Tarnopolsky, Mats I. Nilsson

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Long-term outcome and unmet needs in infantile-onset Pompe disease

Andreas Hahn, Anne Schänzer

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Multisystem late onset Pompe disease (LOPD): an update on clinical aspects

Antonio Toscano, Carmelo Rodolico, Olimpia Musumeci

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Immunological challenges and approaches to immunomodulation in Pompe disease: a literature review

Ankit K. Desai, Cindy Li, Amy S. Rosenberg, Priya S. Kishnani

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Diagnostic tools in late onset Pompe disease (LOPD)

Olimpia Musumeci, Antonio Toscano

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Progress and challenges of gene therapy for Pompe disease

Giuseppe Ronzitti, Fanny Collaud, Pascal Laforet, Federico Mingozzi

PDF Full Text

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

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An emerging phenotype of central nervous system involvement in Pompe disease: from bench to bedside and beyond

Aditi Korlimarla, Jeong-A Lim, Priya S. Kishnani, Baodong Sun

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Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

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Challenges in treating Pompe disease: an industry perspective

Hung V. Do, Richie Khanna, Russell Gotschall

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Pompe disease: what are we missing?

Benedikt Schoser

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The role of patient advocacy organizations in shaping medical research: the Pompe model

Tiffany House, Kevin O’Donnell, Raymond Saich, Fabio Di Pietro, Ria Broekgaarden, Allan Muir, Thomas Schaller

PDF Full Text

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Editorial

Physician-owned hospitals in orthopedic and spine surgery

Junyoung Ahn, Scott Blumenthal, Peter B. Derman

A brilliant dawn and an even brighter future for Annals of Translational Medicine

Giuseppe Lippi

Improving our understanding of breast cancer tumorigenesis across ethnicities

Michael J. McKay, Melissa Southey

Wearable cardioverter defibrillators: dead on arrival or chance of survival?

Pooja S. Jagadish, Rami N. Khouzam

Review Article

The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer

Udit Chaddha, D. Kyle Hogarth, Septimiu Murgu

Liquid biopsy for lung cancers: an update on recent developments

Alberto E. Revelo, Alvaro Martin, Ricardo Velasquez, Prarthna Chandar Kulandaisamy, Jean Bustamante, Sevak Keshishyan, Gregory Otterson

Placement of markers to assist minimally invasive resection of peripheral lung lesions

Ricardo Velasquez, Alvaro Martin, Mohammad Abu Hishmeh, Lawrence DeLorenzo, Samjot Singh Dhillon, Kassem Harris

Innovations in functional and rehabilitative knee bracing

Jim Hewlett, John Kenney

Diagnosis and management of peripheral lung nodule

Taha Khan, Yasir Usman, Tony Abdo, Fawad Chaudry, Jean I. Keddissi, Houssein A. Youness

Anesthetic considerations for lung resection: preoperative assessment, intraoperative challenges and postoperative analgesia

Debra Lederman, Jasmeet Easwar, Joshua Feldman, Victoria Shapiro

Contemporary approach to the patient with malignant pleural effusion complicating lung cancer

Oleg Epelbaum, Najib M. Rahman

Management of hemoptysis in patients with lung cancer

Evgeni Gershman, Rachel Guthrie, Kevin Swiatek, Samira Shojaee

Postobstructive pneumonia in lung cancer

Aashish Valvani, Alvaro Martin, Anusha Devarajan, Dipak Chandy

Anesthetic management during bronchoscopy of patients with pulmonary hypertension

Jason Broker, Draginja Cvetkovic, Saman Yaghoubian

Role of bronchoscopy in management of central squamous cell lung carcinoma in situ

Ankit Gupta, Kassem Harris, Samjot Singh Dhillon

Management of air leaks post-surgical lung resection

Matthew E. Bronstein, Donna C. Koo, Tracey L. Weigel

The use of tranexamic acid in spine surgery

Joon S. Yoo, Junyoung Ahn, Sailee S. Karmarkar, Eric H. Lamoutte, Kern Singh

Evidence based treatment options for common knee injuries in runners

Simeon Mellinger, Grace Anne Neurohr

Bronchoscopic ablation techniques in the management of lung cancer

Ray W. Shepherd, Christopher Radchenko

Point of care ultrasound in thoracic malignancy

Matthew J. Miles, Shaheen Islam

Changing reimbursement models and private equity ownership in spine surgery

Matthew S. Galetta, Heeren S. Makanji, John Strony, Dhruv K. C. Goyal, Mark F. Kurd

Immunotherapy and targeted therapy—the new roadmap in cancer treatment

Kamran Shahid, Mustafa Khalife, Raetasha Dabney, Alexandria Phan

Paraneoplastic syndromes in lung cancer and their management

Asad Anwar, Firas Jafri, Sara Ashraf, Mohammad Ali S. Jafri, Michael Fanucchi

The utility of virtual reality and augmented reality in spine surgery

Joon S. Yoo, Dillon S. Patel, Nadia M. Hrynewycz, Thomas S. Brundage, Kern Singh

Malignant pleural effusion and cancer of unknown primary site: a review of literature

Saed Fathi Awadallah, Mark R. Bowling, Nitika Sharma, Arjun Mohan

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Human microbial ecology and the rising new medicine

Filipa Godoy-Vitorino

Post-operative atrial fibrillation: should we anticoagulate?

Pooja S. Jagadish, Irene Kirolos, Sarthak Khare, Aranyak Rawal, Victor Lin, Rami N. Khouzam

An evaluation of biomaterials and osteobiologics for arthrodesis achievement in spine surgery

Joon S. Yoo, Junyoung Ahn, Dillon S. Patel, Nadia M. Hrynewycz, Thomas S. Brundage, Kern Singh

Original Article

Tumor location is an independent prognostic factor of esophageal adenocarcinoma based on the eighth edition of TNM staging system in Chinese patients

Han-Yu Deng, Xi Zheng, Guha Alai, Gang Li, Jun Luo, Ze-Guo Zhuo, Yi-Dan Lin

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Astym^® therapy improves FOTO^® outcomes for patients with musculoskeletal disorders: an observational study

Leah S. Harris, Suzanne Freeman, Ying-Chih Wang

The effect of extension assist orthosis with pneumatic bladders on pain and function for patients with early knee osteoarthritis

Kathleen Madara, Moiyad Aljehani, Federico Pozzi, Elizabeth Colonna, Joseph A. Zeni Jr

Genetic variants and clinical significance of pediatric acute lymphoblastic leukemia

Hong-Hong Zhang, Hong-Sheng Wang, Xiao-Wen Qian, Cui-Qing Fan, Jun Li, Hui Miao, Xiao-Hua Zhu, Yi Yu, Jian-Hua Meng, Ping Cao, Jun Le, Jun-Ye Jiang, Wen-Jing Jiang, Ping Wang, Xiao-Wen Zhai

Quantitative gait analysis for laser cue in Parkinson’s disease patients with freezing of gait

Liang Tang, Wei Xu, Zhikun Li, Yu Chen, Haojie Chen, Ronghua Yu, Xiaodong Zhu, Dongyun Gu

Comparison of Roche Elecsys and Sysmex HISCL immunoassays for the screening of common blood-borne pathogens

Wanzhou Xu, Yongqing Tong, Yan Li

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Attitude and behavior of clinical nurse towards self-health care: a cross-sectional survey

Yi Zhang, Wenqin Wang, Qiaofei Liu, Xinjuan Wu, Min Xiang, Yanwei Zhao, Xiaodong He, Yufen Ma

Alterations of irisin, adropin, preptin and BDNF concentrations in coronary heart disease patients comorbid with depression

Wenxiu Han, Chunxiang Zhang, Hui Wang, Mengqi Yang, Yujin Guo, Gongying Li, Hailiang Zhang, Changshui Wang, Dan Chen, Chunmei Geng, Pei Jiang

Stability evaluation of anterior external fixation in patient with unstable pelvic ring fracture: a finite element analysis

Lan Li, Jingwei Lu, Longfei Yang, Kaijia Zhang, Jing Jin, Guojing Sun, Xingsong Wang, Qing Jiang

Existence of virulence genes in clinical Shigella sonnei isolates from Jiangsu province of China: a multicenter study

Bing Gu, Wenting Fan, Tingting Qin, Xiaoxiao Kong, Chen Dong, Zhongming Tan, Ying Chen, Nana Xu, Ping Ma, Chang-Jun Bao, Huimin Qian

Comprehensive analysis of differentially expressed serum microRNAs in humans responding to Brucella infection

Cuiping Zhang, Quan Fu, Meng Ding, Tingting Chen, Xiaolan Lu, Yujie Zhong, Yuying Bian, Fengmin Zhang, Chen-Yu Zhang, Chunni Zhang, Cheng Wang

Clinical epidemiology and outcomes of biliary tract infections caused by Klebsiella pneumoniae>

Lanyu Li, Changqing Zhu, Huan Huang

Impact of prior cancer on outcomes in nasopharyngeal carcinoma

Huaqiang Zhou, Yaxiong Zhang, Jiaqing Liu, Wenfeng Fang, Yunpeng Yang, Shaodong Hong, Gang Chen, Shen Zhao, Jiayi Shen, Wei Xian, Zhonghan Zhang, Xi Chen, Hongyun Zhao, Yan Huang, Li Zhang

High methylation of ZNF582 in cervical adenocarcinoma affects radiosensitivity and prognosis

Na-Yi Yuan Wu, Xiaoyun Zhang, Tangyuan Chu, Songlin Zhu, Yuping Deng, Yi Zhou, Ying Wang, Xueheng Zhao, Lu Liu, Chao Fang, Yang Wang, Yu-Ligh Liou, Jingting Cai, Jing Wang

Trehalose enhances bone fracture healing in a rat sleep deprivation model

Xingquan Xu, Rongliang Wang, Ziying Sun, Rui Wu, Wenjin Yan, Qing Jiang, Dongquan Shi

Deep convolutional neural network Inception-v3 model for differential diagnosing of lymph node in cytological images: a pilot study

Qing Guan, Xiaochun Wan, Hongtao Lu, Bo Ping, Duanshu Li, Li Wang, Yunjun Wang, Jun Xiang

Efficacy and safety of cinacalcet and active vitamin D in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease: a network meta-analysis

Li-Hua Ni, Cheng Yuan, Kai-Yun Song, Xiao-Chen Wang, Si-Jie Chen, Li-Ting Wang, Yu-Xia Zhang, Hong Liu, Bi-Cheng Liu, Ri-Ning Tang

The association between post-procedural oral hydration and risk of contrast-induced acute kidney injury among ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

Feier Song, Guoli Sun, Jin Liu, Ji-Yan Chen, Yibo He, Shiqun Chen, Guanzhong Chen, Ning Tan, Yong Liu, The RESCIND Group

Preoperative D-dimer level is an independent prognostic factor for non-small cell lung cancer after surgical resection: a systematic review and meta-analysis

Han-Yu Deng, Xi Zheng, Rui Jiang, Rui-Lan Wang, Jie Zhou, Xiao-Ming Qiu

Surgical intervention in renal cell carcinoma patients with lung and bronchus metastasis is associated with longer survival time: a population-based analysis

Shaofeng Lin, Yuxiao Zheng, Zongshi Qin, Xin Hu, Feng Qi, Rong Yin, Lin Xu, Xiao Li

Whole exome sequencing identifies a rare variant in DAAM2 as a potential candidate in idiopathic pulmonary ossification

Sheng-Wen Sun, Mei Zhou, Long Chen, Jiang-Hua Wu, Zhao-Ji Meng, Shuai-Ying Miao, Hong-Li Han, Chen-Chen Zhu, Xian-Zhi Xiong

Anti-atherosclerotic effects between a combined treatment with simvastatin plus hirudin and single simvastatin therapy in patients with early type 2 diabetes mellitus

De-Qiang Li, Fei-Fei Lv, Zhong-Chun Li, Zhi-Yuan Dai, Hong-Xia Wang, Yang Han

Primary colorectal lymphoma: computed tomography and double-contrast barium enema examination findings with histopathological correlation in 19 patients

Meng Li, Li Zhang, Xin Liang, Wen-Ting Huang, Jing-Wen Ma, Yuan Wan, Ning Wu

Exenatide reduces cardiomyocyte apoptosis by stimulating adiponectin secretion and activating APPL1-AMPK-PPARα axis

Xiaotian Lei, Qinan Wu, Weiling Leng, Minxia Wu, Liu Chen, Ziwen Liang

The 100 most cited manuscripts in esophageal motility disorders: a bibliometric analysis

Dimitrios Schizas, Panagiotis Kapsampelis, Diamantis I. Tsilimigras, Prodromos Kanavidis, Dimitrios Moris, Ioannis S. Papanikolaou, Georgios P. Karamanolis, Dimitrios Theodorou, Theodore Liakakos

Differential expression of genes associated with hypoxia pathway on bone marrow stem cells in osteoporosis patients with different bone mass index

Qi Zhu, Chang Shan, Ling Li, Lige Song, Keqin Zhang, Yun Zhou

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

Catalpol may improve axonal growth via regulating miR-124 regulated PI3K/AKT/mTOR pathway in neurons after ischemia

Huifeng Zhu, Jinghuan Wang, Yali Shao, Dong Wan

Postoperative albumin-bilirubin grade and albumin-bilirubin change predict the outcomes of hepatocellular carcinoma after hepatectomy

Linsen Ye, Rongpu Liang, Jiebin Zhang, Chaojin Chen, Xiaolong Chen, Yi Zhang, Guoying Wang, Yang Yang, Guihua Chen

Concurrent liposomal paclitaxel and cisplatin chemotherapy improved outcomes for locally advanced esophageal squamous cell carcinoma treated with intensity-modulated radiotherapy

Shu Liu, Sheng-Nan Ren, Wen-Xiu Ding, Xiao-Lin Ge, Yuan-Dong Cao, Sheng Zhang, Fu-Xi Zhen, Xin-Chen Sun

Personal factors influencing breast cancer patients’ perception of breast conservation surgery in West China

Li Zhang, Jidong Gao, Dongcai Lin, Li Xie, Tianyu Wang, Liqun Zou

Combining endoscopic ultrasound and tumor markers improves the diagnostic yield on the etiology of common bile duct dilation secondary to periampullary pathologies

Han Ding, Pinghong Zhou, Meidong Xu, Weifeng Chen, Quanlin Li, Tao Chen, Mingyan Cai, Tianyin Chen, Jingjing Lian, Yiqun Zhang

Prevalence of and factors related to microvascular complications in patients with type 2 diabetes mellitus in Tianjin, China: a cross-sectional study

Huyen Dieu Thi Bui, Xiyue Jing, Rui Lu, Jiageng Chen, VanManh Ngo, Zhuang Cui, Yuanyuan Liu, Changping Li, Jun Ma

Clinical features and pregnancy outcomes of women with abnormal cell-free fetal DNA test results

Qin Zhou, Zhi-Ping Zhu, Bin Zhang, Bin Yu, Zheng-Mao Cai, Pei Yuan

Perioperative lymphocytopenia predicts mortality and severe complications after intestinal surgery

Marco Chiarelli, Pietro Achilli, Fulvio Tagliabue, Ariberto Brivio, Angelo Airoldi, Angelo Guttadauro, Francesca Porro, Luca Fumagalli

End-expiratory occlusion test predicts fluid responsiveness in cardiac surgical patients in the operating theatre

Li-Ying Xu, Guo-Wei Tu, Jing Cang, Jun-Yi Hou, Ying Yu, Zhe Luo, Ke-Fang Guo

Phylogenetic analysis of clinical strains of Helicobacter pylori isolated from patients with gastric diseases in Tibet

Mingjiang Bie, Jirui Wen, Hongren Wang, Linlin Zhou, Lijun Yang, Yongyue Pan, Jun Luo, Chao Liu, Mingyuan Li, Baoning Wang

Non-operative treatment options for knee osteoarthritis

Michael DeRogatis, Hiba K. Anis, Nipun Sodhi, Joseph O. Ehiorobo, Morad Chughtai, Anil Bhave, Michael A. Mont

Cinacalcet attenuated bone loss via inhibiting parathyroid hormone-induced endothelial-to-adipocyte transition in chronic kidney disease rats

Li-Hua Ni, Ri-Ning Tang, Cheng Yuan, Kai-Yun Song, Li-Ting Wang, Xiao-Liang Zhang, Lin-Li Lv, Bin Wang, Min Wu, Tao-Tao Tang, Zuo-Lin Li, Di Yin, Jing-Yuan Cao, Xiao-Chen Wang, Hong Liu, Qiang Chen, Bi-Cheng Liu

Two novel mutations of PEX6 in one Chinese Zellweger spectrum disorder and their clinical characteristics

Hui-Ling Yu, Yan Shen, Yi-Min Sun, Yue Zhang

Quality of life in patients with bronchiectasis: a 2-year longitudinal study

Anil Magge, Shehryar Ashraf, Alexandra L. Quittner, Mark L. Metersky

Effect of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantation

Hongxia Li, Yiqi Weng, Shaoting Yuan, Weihua Liu, Hongli Yu, Wenli Yu

Effects of GLP-1 receptor analogue liraglutide and DPP-4 inhibitor vildagliptin on the bone metabolism in ApoE^−/− mice

Lizhi Zhang, Peicheng Li, Zhaosheng Tang, Qin Dou, Bo Feng

Are management decisions in critical patients changed with use of hemodynamic parameters from transpulmonary thermodilution technique?

Ye Rim Chang, Seok Ho Choi, Sung Wook Chang

Mitral valve replacement via minimally invasive totally thoracoscopic surgery versus traditional median sternotomy: a propensity score matched comparative study

Jian Liu, Bo Chen, Yu-Yuan Zhang, Liang-Zheng Fang, Bin Xie, Huan-Lei Huang, Jing Liu, Cong Lu, Wen-Da Gu, Zhao Chen, Jie-Xu Ma, Hai-Yun Yuan, Ji-Mei Chen, Jian Zhuang, Hui-Ming Guo

Chin-down-plus-larynx-tightening maneuver improves choking cough after esophageal cancer surgery

Yongkui Yu, Yin Li, Yingmin Lu, Xionghuai Hua, Haibo Ma, Haomiao Li, Xiufeng Wei, Jun Zhang, Xiankai Chen, Qi Liu, Zhengshuai Zhu, Lei Xu, Ruixiang Zhang, Haibo Sun, Zongfei Wang

Nocturnal supports for patients with central sleep apnea and heart failure: a systemic review and network meta-analysis of randomized controlled trials

Chongxiang Chen, Tianmeng Wen, Wei Liao

Uric acid level changes after bariatric surgery in obese subjects with type 2 diabetes mellitus

Weijie Liu, Hongwei Zhang, Xiaodong Han, Pin Zhang, Zhongqi Mao

Case Report

Bronchoscopic instillation of DNase to manage refractory lobar atelectasis in a lung cancer patient

Hussein Assallum, Tian Yue Song, Lawrence DeLorenzo, Kassem Harris

Increased neutrophils and IL-17A in a rare organizing pneumonia secondary to extrapulmonary operation

Chaojie Wu, Kun Xu, Zhengxia Wang, Zhongqi Chen, Zhixiao Sun, Wenqing Yu, Ningfei Ji, Mao Huang, Mingshun Zhang

Letter to the Editor

The PD-1/PD-L1 pathway in advanced prostate cancer—have we milked this cow?

Sarah L. Picardo, Aaron R. Hansen

Big-data Clinical Trial Column

Reinforcement learning in clinical medicine: a method to optimize dynamic treatment regime over time

Zhongheng Zhang, written on behalf of AME Big-Data Clinical Trial Collaborative Group

Editorial Commentary

Testing two (of several) intravenous iron dosing strategies in hemodialysis

Margaret K. Yu, Glenn M. Chertow

Immunotherapy for head and neck cancer: where are we now and where are we going?

Joshua M. Bauml, Charu Aggarwal, Roger B. Cohen

Combining immunotherapy and epidermal growth factor receptor kinase inhibitors: worth the risk?

Hira Latif, Stephen V. Liu

Renal function after kidney surgery: “it’s tough to make predictions, especially about the future”

John M. DiBianco, Patrick T. Gomella, Mark W. Ball

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Depth of invasion for prognostic stratification in oral cavity cancer: do we need further validation?

Cesare Piazza, Lorenzo Bresciani, Lorenzo Giannini

Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products

Peter A. D. Wellham, Dong-Hyun Kim, Matthias Brock, Cornelia H. de Moor

Editorial commentary: the multiligament injured knee: current controversies and strategies for improving outcomes

Adnan Saithna

Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

Quante Singleton, Santul Bapat, Sadanand Fulzele

Brain metastases in EGFR-positive non-small cell lung cancer: the way to the sanctuary becomes less winding

Antonio Passaro, Letizia Gianoncelli, Valeria Stati, Filippo de Marinis

Asymmetric dimethylarginine, erythropoietin resistance, and anemia in CKD

Tammy L. Sirich, Glenn M. Chertow

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

New insights into cordycepin production in Cordyceps militaris and applications

Sunita Chamyuang, Amorn Owatworakit, Yoichi Honda

The role of acute kidney injury duration in clinical practice

Chyi-Sheng Khor, Wei-Jie Wang

Current landscape of cytoreductive nephrectomy: who, when, and why?

Jiping Zeng, Alfredo Harb-De la Rosa, Juan Chipollini

Improving patient selection for adjuvant therapy in high-risk renal cell carcinoma

Dylan M. Buller, Benjamin T. Ristau

Risk reduction in kidney surgery

Martin Marszalek

An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution

Lykourgos-Panagiotis Zalmas, Wei-Ting Lu, Nnennaya Kanu

The role of laparoscopic pancreaticoduodenectomy—how take care of patient security?

Trond A. Buanes

Pembrolizumab plus ipilimumab or pegylated interferon alfa-2b for patients with melanoma or renal cell carcinoma: take new drugs but keep the old?

Matthew Zibelman, Elizabeth R. Plimack

State of the art in multiligament knee injuries: from diagnosis to treatment

Marcel Faraco Sobrado

Revisiting the role of lymph node dissection in renal cell carcinoma

Alice Yu, Dimitar V. Zlatev, Michael L. Blute Sr

Lack of evidence regarding bone metastases of genitourinary cancers: interventions by surgery, radiotherapy, and bone-targeted systemic therapy

Makito Miyake, Takuya Owari, Kiyohide Fujimoto

Cellular therapy for autism spectrum disorder: a step forward to the optimal treatments

Dario Siniscalco, Nicola Antonucci

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Stereotactic body radiation therapy for oligometastatic renal cell carcinoma: improving outcomes in an otherwise radioresistant malignancy

Thomas H. Beckham, Brandon S. Imber, Charles B. Simone II

Smoking favours hepatocellular carcinoma

Maria Guarino, Jean-François Dufour

Predicting mortality after postcardiotomy venoarterial extracorporeal membrane oxygenation

Fausto Biancari, Angelo M. Dell’Aquila, Giovanni Mariscalco

Stereotactic body radiation therapy could improve disease control in oligometastatic patients with renal cell carcinoma: do we need more evidence?

Linda Agolli

Role of stereotactic body radiation therapy for the management of renal cell carcinoma: tailoring treatment in the era of the “embarrassment of riches”

Sebastiano Buti, Alessandro Leonetti, Elisabetta Lattanzi, Nunziata D’Abbiero, Melissa Bersanelli

Microfracture for cartilage repair in the knee: current concepts and limitations of systematic reviews

Sang Jun Song, Cheol Hee Park

Lobar or sublobar resections are safe procedures for management of early lung cancer

Alfonso Fiorelli, Immacolata Mauro, Gaetano Cicchitto, Aldo Prencipe, Mario Polverino, Vincenzo Giuseppe Di Crescenzo, Mario Santini

Comment on an external validation of the 8th edition of the TNM classification for lung cancer staging in patients treated with chemoradiation

Ramón Palmero, Arturo Navarro-Martin, Ernest Nadal

TNM in non-small cell lung cancer: a staging system for all oncologists or just for surgeons?

David Ball

Behaviorally associated changes in neuroconnectivity following autologous umbilical cord blood infusion in young children with autism spectrum disorder

Richard E. Frye

Is the adipose-derived mesenchymal stem cell therapy effective for treatment of knee osteoarthritis?

Ilaria Roato, Riccardo Ferracini

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A 7.0–7.7% value for glycated haemoglobin is better than a <7% value as an appropriate target for patient-centered drug treatment of type 2 diabetes mellitus

José Pedro L. Nunes, Joseph P. DeMarco

Immune checkpoint inhibitors for esophageal cancer: are we moving in the right direction?

Alexander G. Raufi, Khaldoun Almhanna

Non-small cell lung cancer 2 cm or less: robotic segmentectomy sets the gold standard against non-surgical therapy

Dana Ferrari-Light, Robert J. Cerfolio

Reconsider minimally invasive surgery for early cervical cancer

Yi Zhang, Shuguang Chen

Urologic and interventional radiology treatment of renal cell carcinomas—similarities and differences

Diep Nguyen, Eric vanSonnenberg, Paul Kang, Peter R. Mueller

The effect of centralization of abdominal aortic aneurysm repair procedures on perioperative outcomes

Kosmas I. Paraskevas

Arterial erectile dysfunction is an early sign of vascular damage: the importance for the prevention of cardiovascular health

Sandro La Vignera, Rosita A. Condorelli, Rossella Cannarella, Filippo Giacone, Aldo E. Calogero

Comment for “nomogram establishment for surgery-related complications in partial nephrectomy”

Katsumi Shigemura, Shian-Ying Sung, Kuan-Cho Chen, Masato Fujisawa

Salvage procedures for chronic gastric leaks after sleeve gastrectomy: the role of laparoscopic Roux-en-Y fistulo-jejunostomy

Panagiotis Lainas, Naim Schoucair, Carmelisa Dammaro, Ibrahim Dagher

Fluoxetine in stroke (FOCUS) trial—reasons to be cheerful about antidepressants in stroke?

Terence J. Quinn

Extended follow-up on KEYNOTE-024 suggests significant survival benefit for pembrolizumab in patients with PD-L1 ≥50%, but unanswered questions remain

Jose M. Pacheco, Dexiang Gao, D. Ross Camidge

Serum neurofilament light chain rate of change in Alzheimer’s disease: potentials applications and notes of caution

Federico Massa, Riccardo Meli, Silvia Morbelli, Flavio Nobili, Matteo Pardini

Vitamin C’s essential role in DNA and histone demethylation and a preclinical rationale for its therapeutic high-dose potential in renal cell carcinoma

Ching-Hui Huang, Chia-Chu Chang

Looking beyond cancer for cabozantinib-induced cardiotoxicity: evidence of absence or absence of evidence?

Eugenia Y. Lee, Andrew T. Yan

Key players of neuroendocrine differentiation in prostate cancer

Matteo Santoni, Gaetano Aurilio, Alessandro Maccioni, Franco Nolè, Nicola Battelli

Spine surgeon ownership of ambulatory surgery centers

Andre M. Samuel, Mark T. Langhans, Sravisht Iyer

New promising circulating RNA biomarkers for early diagnosis of lung adenocarcinoma

Francisco J. Enguita

VCAM-1+ macrophages usher hematopoietic stem and progenitor cell to vascular niche “hotspots”

Yahui Grace Chiu, Omar S. Aljitawi

Immunotherapy for mucosal melanoma

Sarah Yentz, Christopher D. Lao

⁶⁸Ga-dotatoc vs. ¹⁸F-FDG vs. radiolabelled PSMA PET/CT in renal cancer patients

Laura Evangelista, Fabio Zattoni, Pierpaolo Alongi

Spread through air spaces-positive T1 lung adenocarcinoma: is lobectomy associated with better outcomes than sublobar resection?

Kathleen Weiss, Matthew M. Rochefort

Prevention of cognitive decline in old age—varying effects of interventions in different populations

Chengxuan Qiu, Gunilla Johansson, Feiqi Zhu, Miia Kivipelto, Bengt Winblad

Role of cytoreductive nephrectomy in metastatic renal cell carcinoma patients with tumor thrombus: does it change with development of systemic therapy?

Fumitaka Koga

Long-term survival following thoracoscopic versus open lobectomy for stage I non-small cell lung cancer

Hussein Elkhayat, Diego Gonzalez Rivas

Personalized medicine in breast cancer: a step forward

Alejandro Martin Sanchez, Gianluca Franceschini, Daniela Terribile, Sabatino D’Archi, Lorenzo Scardina, Riccardo Masetti

Renal cell carcinoma response to checkpoint inhibitors may be predicted by senescence activity in tumor microenvironment

Javier González, Gaetano Ciancio

Progress in interferon-gamma release assay development and applications: an unfolding story of translational research

Ajit Lalvani, Hilary S. Whitworth

Post-operative surveillance in kidney cancer

Ofer Gofrit, Marina Orevi

Another one in the chamber: cabozantinib for patients with metastatic non clear cell renal cell carcinoma

Vincenzo Di Nunno, Francesco Massari, Veronica Mollica, Alessia Cimadamore, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi

Predicting biological behaviour of newly diagnosed renal masses: a possible role of cell proliferation biomarkers?

Riccardo Mastroianni, Aldo Brassetti, Manuela Costantini, Giuseppe Simone

New insights in predictive determinants of the tumor immune microenvironment for immune checkpoint inhibition: a never ending story?

Markus Eckstein, Shilpa Gupta

A critical evaluation of the role of robotic-assisted surgery in complex pediatric urology cases

Patricio Gargollo

Cardiovascular and renal protection with sodium-glucose cotransporter type 2 inhibitors: new paradigm in type 2 diabetes management…and potentially beyond

André J. Scheen

Is nodal disease burden relevant in patients with renal cell carcinoma and lymph node invasion?

Francisco Rodriguez-Covarrubias

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Do hypofraction and large breast size reciprocally fit in breast cancer radiotherapy?

Pierfrancesco Franco, Sara Bartoncini, Stefania Martini, Giuseppe Carlo Iorio, Umberto Ricardi

Nephrometry score correlated with tumor proliferative activity inT1 clear cell renal cell carcinoma—the tiger in the tall grasses versus the cat in plain sight

Ziting Wang, Ho Yee Tiong

Should we perform peripheral laser iridotomy in primary angle closure suspects: implications of the ZAP trial?

Vivek Gupta, Tanuj Dada

FOCUS trial: results, potentialities and limits

Luca Saba, Antonella Balestrieri, Alessandra Serra, Raimondo Garau, Carola Politi, Pierleone Lucatelli, Alessandro Murgia, Jasjit S. Suri, Lorenzo Mannelli

Outcome of safety and efficacy of allogeneic mesenchymal stromal cell derived from umbilical cord for the treatment of osteoarthritis in a randomized blinded placebo-controlled trial

Kiran Shah, Huseyin Sumer

Breakthroughs and challenges in the management of tropomyosin receptor kinase fusion-positive tumors

Hirva Mamdani, Shadia I. Jalal

Better screened than sorry!—an informed panel of inherited DNA repair gene variants for prostate cancer screening and prognostication

Giulia Fracassi, Francesca Lorenzin, Francesca Demichelis

The 8^th UICC/AJCC TNM edition for non-small cell lung cancer staging: getting off to a flying start?

Andrea Lancia, Elisa Merizzoli, Andrea Riccardo Filippi

Testicular germ cell tumors: the changing role of the pathologist

Andrea Ronchi, Francesca Pagliuca, Renato Franco

Apixaban or rivaroxaban in the treatment of acute venous thromboembolism?

Maja Hellfritzsch, Erik L. Grove, Kasper Adelborg

Prolonged albumin administration in patients with decompensated cirrhosis: the amount makes the difference

Manuel Tufoni, Giacomo Zaccherini, Paolo Caraceni

Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response

Faustino Mollinedo, Consuelo Gajate

Turning stem cells homing potential into cancer specific drug delivery machines

Nedime Serakinci, Huseyin Cagsin

MGTX extension study longitudinally favors early thymectomy in non-thymomatous young-adult patients with AChR antibody-positive myasthenia gravis

Tetsuya Akaishi, Masakatsu Motomura, Masashi Aoki, Kimiaki Utsugisawa

Pembrolizumab monotherapy for PD-L1 ≥50% non-small cell lung cancer, undisputed first choice?

Willemijn S. M. E. Theelen, Paul Baas

Suggestions for radiation oncologists to overcome radiotherapy interruption in patients with nasopharyngeal cancer

Jung Ae Lee, Won Sup Yoon

Cytoreductive nephrectomy in patients with metastatic renal cell carcinoma and venous thrombus—trends and effect on overall survival

Aye A. Lwin, Grant R. Pollock, Juan Chipollini

Stereotactic ablative radiotherapy for early-stage central lung tumors: status, challenges, and future considerations

Ming Li, Cheng Zhan

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.