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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Original Article

Frailty in elderly ICU patients in Greece: a prospective, observational study
Dimitris Papageorgiou, Eleni Gika, Konstantina Kosenai, Konstantinos Tsironas, Lamprini Avramopoulou, Ervina Sela, Christina Mandila
Trends in total ankle arthroplasty and revisions in the Medicare database
Tsun Yee Law, Karim G. Sabeh, Samuel Rosas, Zachary Hubbard, Sarah Altajar, Martin W. Roche
Total knee replacement modifies the preoperative tibial torsion angle—similar results between computer-assisted and standard technique
Daniel Hernandez-Vaquero, Alfonso Noriega-Fernandez, Sergio Roncero-Gonzalez, Andres A. Sierra-Pereira, Manuel A. Sandoval-Garcia
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
No association between systemic complement activation and intensive care unit-acquired weakness
Esther Witteveen, Luuk Wieske, Friso M. de Beer, Nicole P. Juffermans, Camiel Verhamme, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn, on behalf of the BASIC study group

Case Report

Teeth infection may “shunt” through Fontan in high-altitude conditions
Juan D. Cano Sierra, Camilo F. Mestra, Juan C. Gelvez Nieto, Miguel Ronderos Dumit, Alberto García-Torres

Big-data Clinical Trial Column

Exploring heterogeneity in clinical trials with latent class analysis
Zhongheng Zhang, Abdallah Abarda, Ateka A. Contractor, Juan Wang, C. Mitchell Dayton
Estimate risk difference and number needed to treat in survival analysis
Zhongheng Zhang, Federico Ambrogi, Alex F. Bokov, Hongqiu Gu, Edwin de Beurs, Khaled Eskaf
Time-varying covariates and coefficients in Cox regression models
Zhongheng Zhang, Jaakko Reinikainen, Kazeem Adedayo Adeleke, Marcel E. Pieterse, Catharina G. M. Groothuis-Oudshoorn
Subgroup identification in clinical trials: an overview of available methods and their implementations with R
Zhongheng Zhang, Heidi Seibold, Mario V. Vettore, Woo-Jung Song, Vieille François

Editorial of Column in Hypertension

Antihypertensive drug therapy
Wilbert S. Aronow


Puzzle over active surveillance for micropapillary thyroid carcinoma
Hui Sun, Paolo Carcoforo, Gianlorenzo Dionigi


A critical electrocardiographic pattern in the age of cardiac biomarkers
Eduardo Matos Vilela, Francisco Sampaio, Tiago Dias, Ana Raquel Barbosa, João Primo, Daniel Caeiro, Marlene Fonseca, Vasco Gama Ribeiro

Letter to the Editor

Histological examination of post-mortem brains of children with nodding syndrome
An Hotterbeekx, Sylvester Onzivua, Sonia Menon, Robert Colebunders
Primary melanoma of the testis: myth
Francesco Fortarezza, Senia Maria Rosaria Trabucco, Annunziata De Luisi, Nicoletta Resta, Antonia Cimmino, Andrea Marzullo, Marco Moschetta, Teresa Lettini, Gabriella Serio
Incorrect cell line validation and verification
Jaime A. Teixeira da Silva


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.


Review Article

Original Article

Case Report

Surgical Technique