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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

Endorsement
Endorsement
Endorsement

the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Neoadjuvant immunotherapy for patients with non-small cell lung cancer—current evidence
Christopher Cao, Allen Guo, Christopher Chen, Rob Zielinski, Matthew Bott

Original Article

Analysis of population health projects funded by Joint Fund of the National Natural Science Foundation of China between 2015 and 2019
Rong Lei, Jinglin Zhang, Hongmei Zhou, Quan Liu, Hao Wang, Jia Liu
Comparative expression analysis of PD-1, PD-L1, and CD8A in lung adenocarcinoma
Ke Ma, Yulei Qiao, Hao Wang, Shuai Wang
Analysis of the economic performance of municipal Children’s Hospitals in Shanghai: a study on the impacts of policy changes in healthcare service prices
Yuanyuan An, Miao Wang, Xiaoyu Wu, Linan Wang, Kunkun Zhang
Effects of dexmedetomidine as an adjuvant in thoracic paravertebral block on EC50 of propofol for successful laryngeal mask insertion: a randomized controlled trial
Fei Guo, Hao Chen, Xuejiao Cai, Jianlin Ge, Boxiang Du, Jie Song
Correlation between alterations of gut microbiota and miR-122-5p expression in patients with type 2 diabetes mellitus
Lisha Li, Chaomin Li, Meijun Lv, Qiongying Hu, Lixuan Guo, Daqian Xiong
Application of hybrid particle swarm and ant colony optimization algorithms to obtain the optimum homomorphic wavelet image fusion
Yonghong Jiang, Yaning Ma
Regulatory T cell and activated natural killer cell infiltration in hepatocellular carcinoma: immune cell profiling using the CIBERSORT
Lixin Wang, Zongguo Yang, Yajuan Cao
Whole-exome sequencing identifies prognostic mutational signatures in gastric cancer
Zhenxin Zhu, Hongbing Fu, Shengzhou Wang, Xinxin Yu, Qing You, Mengyao Shi, Chun Dai, Guan Wang, Wei Cha, Weimin Wang
A multi-center randomized controlled trial of the LenoMed ATA-I-1-0 insulin pump for the intensive treatment of diabetic patients
Jin Du, Li Zang, Yufeng Li, Jia Liu, Lijuan Wang, Yan Duan, Guangxia Guo, Yijun Li, Yajing Zhang, Guang Wang, Yiming Mu
The effectiveness of uterine parametrics measured by three-dimensional transvaginal sonography in the diagnosis of uterine cavity distortions
Yan Lin, Min Liu, Suhui He, Minmin Yang, Qiumei Wu
Remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits IL-1β-induced apoptosis of articular chondrocytes via inhibition of PI3K/AKT/NF-κB phosphorylation
Hai Ke, Xiaping Mou, Qing Xia
Comparison of internal target volumes defined by three-dimensional, four-dimensional, and cone-beam computed tomography images of a motion phantom
Yu Wang, Tao Liu, Huiqin Chen, Penggang Bai, Qiong Zhan, Xiaohua Liang
Three-year clinical outcomes of a sirolimus-eluting bioresorbable scaffold (XINSORB) and a metallic stent to treat coronary artery stenosis
Yizhe Wu, Zhifeng Yao, Jiasheng Yin, Jiahui Chen, Juying Qian, Li Shen, Lei Ge, Junbo Ge, on behalf of the XINSORB randomized clinical trial
A stereological study of 3D printed tissues engineered from rat vaginas
Yanpeng Tian, Shuangdan Zhao, Jiahua Zheng, Zhongkang Li, Chenxiao Hou, Xuejun Qi, Desheng Kong, Jingkun Zhang, Xianghua Huang
Assessment of neutrophil gelatinase-associated lipocalin as an early biomarker for canine renal ischemia-reperfusion injury
Jun Cao, Xiaofeng Lu, Fei Gao, Xinyu Zhang, Xiaoli Xia, Huaichang Sun
A HPV16-related prognostic indicator for head and neck squamous cell carcinoma
Qian Zhang, Yongfeng Chen, Shi-Qi Hu, Yu-Mei Pu, Kai Zhang, Yu-Xin Wang
Target therapy for metastatic alveolar soft part sarcoma: a retrospective study with 47 cases
Jiayong Liu, Zhengfu Fan, Shu Li, Tian Gao, Ruifeng Xue, Chujie Bai, Lu Zhang, Zhichao Tan, Zhiwei Fang
MUC16 affects the biological functions of ovarian cancer cells and induces an antitumor immune response by activating dendritic cells
Yan Zhai, Qi Lu, Tong Lou, Guangming Cao, Shuzhen Wang, Zhenyu Zhang
Repair of severe traumatic nasal alar defects with combined pedicled flap and conchal cartilage composite grafts: a retrospective study
Zhenyu Zhang, Lihui Cheng, Tony Chieh-Ting Huang, Hua Hu, Ruiqi Liu, Yi Pu, Ru Wang, Zhengyong Li, Junjie Chen, Ying Cen, Guopeng Liang, Yong Qing
MicroRNA-29b targeting of cell division cycle 7-related protein kinase (CDC7) regulated vascular smooth muscle cell (VSMC) proliferation and migration
Qunhua Ma, Jing Zhang, Ming Zhang, Huan Lan, Qian Yang, Chengping Li, Li Zeng
Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation
Chuanmei Xie, Jing Jiang, Jianping Liu, Guohua Yuan, Zhenyi Zhao
Delivery of vascular endothelial growth factor (VEGFC) via engineered exosomes improves lymphedema
Bohan Li, Jiantao Yang, Raoping Wang, Jia Li, Xubo Li, Xiang Zhou, Shuai Qiu, Ricong Weng, Zichao Wu, Chunyuan Tang, Ping Li
ET-1 regulates the human umbilical vein endothelial cell cycle by adjusting the ERβ/FOXN1 signaling pathway
Yuyan Wang, Yunjun Ruan, Saizhu Wu
MicroRNA-25-3p therapy for intervertebral disc degeneration by targeting the IL-1β/ZIP8/MTF1 signaling pathway with a novel thermo-responsive vector
Yong Huang, Leizhen Huang, Li Li, Zhishen Ge, Ganjun Feng, Limin Liu, Yueming Song
Fucoidan attenuates hyperoxia-induced lung injury in newborn rats by mediating lung fibroblasts differentiate into myofibroblasts
Yan Zhang, Hengjian Du, Xuelian Yu, Jiang Zhu
Human retinal pigment epithelial cells are protected against hypoxia by BNIP3
Jingyang Feng, Wei Tan, Tong Li, Quan Yan, Hong Zhu, Xiaodong Sun
Comparison of topological properties of functional brain networks with graph theory in temporal lobe epilepsy with different duration of disease
Xiulin Liang, Xiaomin Pang, Jinping Liu, Jingyuan Zhao, Lu Yu, Jinou Zheng
Role of lncRNA FTX in invasion, metastasis, and epithelial-mesenchymal transition of endometrial stromal cells caused by endometriosis by regulating the PI3K/Akt signaling pathway
Huixiang Wang, Chengxiang Ni, Wei Xiao, Sulin Wang
Glycemic variability as predictor of contrast-induced nephropathy in diabetic patients with acute myocardial infarction undergoing percutaneous coronary intervention
Pengfei Zuo, Yongjun Li, Zhi Zuo, Xin Wang, Genshan Ma
Xiaoyaosan (Tiaogan-Liqi therapy) protects peritoneal macrophages from corticosterone-induced stress by regulating the interaction between glucocorticoid receptor and ABCA1
Mingtai Chen, Ruolan Huang, Wenjun Fu, Lijun Ou, Ling Men, Zhong Zhang, Shudong Yang, Qiang Liu, Jienan Luan
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective
Yuying Hao, Pingping Hu, Jiandong Zhang
LMCD1 antisense RNA 1 (LMCD1-AS1) potentiates thyroid cancer cell growth and stemness via a positive feedback loop of LMCD1-AS1/miR-1287-5p/GLI2
Jie Shao, Yonggang Xu, Haixia Li, Lu Chen, Wenjuan Wang, Danfeng Shen, Jinhong Chen
Establishment of multiplex allele-specific blocker PCR for enrichment and detection of 4 common EGFR mutations in non-small cell lung cancer
Hongyuan Chen, Jie Zhang, Hong-Yan Chen, Bo Su, Daru Lu
High concentrations of H7 human embryonic stem cells at the point of care for acute myocardial infarction
Yujie Shi, Ya Zhao, Yang Li, Jun Yi, Yue Ma, Yundai Chen
Cangxitongbi capsule protects articular cartilage of the knee in rats by regulating ADAMTS-5
Xu-Yu Song, Wen-Peng Xie, Peng Zhang, Min Zhao, Rong-Xiu Bi
An experimental study on the safe placement of sacroiliac screws using a 3D printing navigation module
Xuanhuang Chen, Feng Zheng, Guodong Zhang, Xiaoqiang Gao, Ya Wang, Wenhua Huang, Haibin Lin
Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage
Shang Xie, Xiao-Feng Shan, Vicky Yau, Jian-Yun Zhang, Xin-Yuan Zhang, Yong-Pan Yan, Zhi-Gang Cai
Pressure overload promotes cystatin C secretion of cardiomyocytes to regulate the MAPK signaling pathway and mediate cardiac hypertrophy
Yi Shen, Xiaoyi Zhang, Chenguang Li, Xiang Wang, Yong Ye, Jie Yuan, Hui Gong, Yunzeng Zou, Junbo Ge
Analysis of the variation pattern in left upper division veins and establishment of simplified vein models for anatomical segmentectomy
Min Zhang, Ning Mao, Ke Zhang, Miao Zhang, Yun Liu, Ren-Feng Wang, Tao Xiong, Gang Huang, Jian-Fei Shen, Jun Liu, Qing-Chen Wu, Ming-Jian Ge
Genome-wide analysis of long non-coding RNA expression profile in lung adenocarcinoma compared to spinal metastasis
Houlei Wang, Annan Hu, Yun Liang, Ketao Wang, Xiaogang Zhou, Jian Dong
Efficacy of video-assisted anal fistula treatment combined with closure of the internal opening using a stapler for Parks II anal fistula
Yuru Zhang, Fei Li, Tuanjie Zhao, Feng Cao, Yamin Zheng, Ang Li
LncRNA FAM83H-AS1 maintains intervertebral disc tissue homeostasis and attenuates inflammation-related pain via promoting nucleus pulposus cell growth through miR-22-3p inhibition
Xin Jiang, Dong Chen
Glutathione ethyl ester supplementation prevents airway hyper-responsiveness in mice
Qiaoyun Wang, Aimin Li, Yiqiong Zheng, Shu Zhang, Ping Wang
Reconstruction of the hepatic artery using the superior mesenteric artery for liver transplantation
Jiali Fang, Zheng Chen, Nan Jiang, Qiang He, Shaoping Wang, Weiting Zhang, Junjie Ma, Guanghui Li, Lei Zhang, Lu Xu, Wei Yin, Xingqiang Lai, Rongxin Chen, Li Li, Luhao Liu, Yunyi Xiong, Tao Zhang, Hailin Xu, Jiao Wan, Jialin Wu, Guanghui Pan, Bingyi Shi, Kun Li
Correlation of carbonic anhydrase 9 (CA9) with pathological T-stage and prognosis in patients with oral tongue squamous cell carcinoma
Shuang Wang, Zhiguang Fu, Yizhu Wang, Yaping Sun, Lei Cui, Chunfang Wang, Qiaoling Liu, Dan Shao, Yu Wang, Ning Wen
The overexpression of maspin increases the sensitivity of lung adenocarcinoma drug-resistant cells to docetaxel in vitro and in vivo
Qian Sun, Kai Zhang, Huan Li, Weiwei Chen, Leilei Liu, Guichun Huang, Qun Zhang, Jing Wang, Lu Lu, Longbang Chen, Rui Wang
A study on the pathogenesis of blood-heat psoriasis with transcriptome analysis
Zhaoxia Chen, Yan Wang, Jingxia Zhao, Dongmei Zhou, Jingjing Lv, Guangzhong Zhang, Tingting Di, Ping Li
Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling
Qiuxian Wan, Lilei Zhang, Ziwei Huang, Haiyan Zhang, Jing Gu, Hua Xu, Xiaoming Yang, Yuntian Shen, Betty Yuen-Kwan Law, Jianwei Zhu, Hualin Sun

iMDT Corner

Transcatheter closure for the treatment of pseudoventricular aneurysm after acute myocardial infarction: a case report
Wei Zhong, Zhidong Liu, Weixiong Fan, Bin Ou, Min Zhong, Zhiwen Zeng, Xianfang Wang, Wilbert S. Aronow, Francesco Nappi, Juan Lacalzada-Almeida, Zhixiong Zhong
Research trends and performances of breast reconstruction: a bibliometric analysis
Yunzhu Li, Xiaojun Wang, Jørn Bo Thomsen, Maurice Y. Nahabedian, Naohiro Ishii, Warren M. Rozen, Xiao Long, Yuh-Shan Ho

Editorial Commentary

Tivozanib in advanced inoperable hepatocellular carcinoma: considerations for patients with liver cirrhosis
Hyunwoo Oh, Jeong-Hoon Lee
Cigarette smoking and lung function decline beyond quitting
Jennifer L. Perret, E. Haydn Walters
Angiogenesis inhibitors for advanced hepatocellular carcinoma: in search for the right partner
Claudia Campani, Lorenza Rimassa, Nicola Personeni, Fabio Marra
A biologically effective dose threshold for stereotactic body radiation therapy—can we put the issue to BED?
Michael Mix, Jeffrey A. Bogart
Macrophage depletion: a potential immunomodulator treatment of endometriosis-associated pain?
Thomas M. D’Hooghe, Arne Vanhie, Valerie A. Flores, Hugh S. Taylor
Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?
Charlotte K. Boughton, Roman Hovorka
The LncRNA, the phosphatase, and the macrophage: can they team up for support in inflammatory diseases?
Marcel Kuhny, Michael Huber
IMPassionate about immunotherapy for TNBC: from change, to revolution and to cure?
Elena Vagia, Massimo Cristofanilli
MET immunochemistry: a reliable screening tool for MET exon 14 skipping mutations in non-small cell lung cancer?
Melinda A. Pruis, Jan H. von der Thüsen, Hendrikus Jan Dubbink
Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease
Anirudh R. Gone, Wei Chen

Editorial on Recent Developments in Cataract Surgery1

Recent developments in cataract surgery
Andrzej Grzybowski

Review Article on Recent Developments in Cataract Surgery1

Lens regeneration in humans: using regenerative potential for tissue repairing
Zhenzhen Liu, Ruixin Wang, Haotian Lin, Yizhi Liu
Recent developments in the management of congenital cataract
Dominique Bremond-Gignac, Alejandra Daruich, Matthieu P. Robert, Sophie Valleix
A narrative review of intraoperative floppy iris syndrome: an update 2020
Xue Yang, Zhaochuan Liu, Zhigang Fan, Andrzej Grzybowski, Ningli Wang
A narrative review of intraocular lens opacifications: update 2020
Andrzej Grzybowski, Agne Markeviciute, Reda Zemaitiene
Postoperative Endophthalmitis and Toxic Anterior Segment Syndrome Prophylaxis: 2020 Update
Jesse D. Sengillo, Ying Chen, Diley Perez Garcia, Stephen G. Schwartz, Andrzej Grzybowski, Harry W. Flynn Jr
Intraocular vision-improving devices in age-related macular degeneration
Andrzej Grzybowski, Jin Wang, Feifei Mao, Dabo Wang, Ningli Wang
The role of lens extraction in glaucoma management
Jolly L. Tsui, Noel C. Chan, Clement C. Tham
The history of cataract surgery: from couching to phacoemulsification
Christopher T. Leffler, Andrey Klebanov, Wasim A. Samara, Andrzej Grzybowski
Advances in pharmacotherapy of cataracts
Jingjie Xu, Qiuli Fu, Xiangjun Chen, Ke Yao
Recent developments in intraocular lens power calculation methods—update 2020
Giacomo Savini, Leonardo Taroni, Kenneth J. Hoffer
Evolution of and developments in simultaneous bilateral cataract surgery. Update 2020
Gurinder Singh, Andrzej Grzybowski

Retraction

Retraction “Methylation of the MAOA promoter is associated with schizophrenia
Hao Yang, Jiajue Li, Aicen Ji, Liping Hu, Xiufeng Zhang, Linlin Liu, Lili Qing, Ming Yan, Shengjie Nie

Disclosure:

1. The series “Recent Developments in Cataract Surgery” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Andrzej Grzybowski served as the unpaid Guest Editor for the series.

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report


Editorial


Editorial Commentary



Original Article


Review Article


Erratum

Erratum to development and formulation of the classification criteria for osteoarthritis
Cibo Huang, Zhiyi Zhang, Yaolong Chen, Yue Zhang, Dan Xing, Like Zhao, Jianhao Lin, Yifang Mei, Hsiao-Yi Lin, Yi Zheng, Wei-Chung Tsai, Shengyun Liu, Quan Jiang, Yi Liu, Jinwei Chen, Zhizhong Ye, Min Chen, Yingjuan Chen, Cong-Qiu Chu, Ming Gao, Lan He, Jin Lin, Lijun Wu, Jianhua Xu, Pinting Yang, Xuewu Zhang, Qing Jiang, Guanghua Lei, Mengtao Li, Wanling Yang, Xin Gu, Yixin Zhou, Dongyi He, Wei Liu, Weiya Zhang, Changhai Ding, Xiaofeng Zeng, on behalf of the COACH Group