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Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

Good news continues to roll in! Announced by Clarivate Analytics, former Thomson Reuters Intellectual Property and Science Business, Annals of Translational Medicine (known as ATM), under AME Publishing Company, is officially indexed in Science Citation Index Expanded (SCIE) on 02 March, 2018

2017 Annual Report of ATM

We are glad to present the 2017 Annual Report of ATM here. In 2017, ATM progressed fast and smoothly under the join-efforts of experts worldwide. The total citation number has significantly increased from 1294 in January to 3314 in December. The journal was also exhibited in some international meetings, to attract wider attention and exposure. More information is shown in the Annual Report.
We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy, healthy and prosperous 2018!

Focus on “Lung Cancer Update 2017: from the test tube to the bed” edited by Drs. Luca Bertolaccini, Federico Cappuzzo and Piergiorgio Solli

Lung cancer is the primary cause of cancer deaths and continues to be a significant global health problem. However, remarkable progress is underway in both the prevention and treatment of lung cancer. Lung cancer therapy has now emerged as a role model for tailored cancer medicine, with several significant breakthroughs. In this issue of the Annals of Translational Medicine, outleading authors have introduced another valued educational source with the newest advances in not small cell lung cancer to keep busy practitioners, scientists, and others interested in lung cancer up-to-date.

Focus on “Esophageal Cancer” edited by Dr. Po-Kuei Hsu

Esophageal cancer is one of the most common cancers worldwide. Surgical resection was considered to be the most important part of treatments, and the only way for complete disease control. Previous studies have focused on the surgical techniques and the approaches, e.g., transthoracic or transhiatal, as well as the extent of lymphadenectomy, e.g., two or three field lymph node dissection. With the understanding of esophageal cancer biology and the evolving of diagnosis and treatment modalities, esophageal cancer is now in the multidisciplinary era. Surgery alone is no longer enough for all kinds of esophageal cancer. The improvements in endoscopic treatment, surgery, chemotherapy and radiotherapy open the possibility for a better selecting patients for personalized treatments.

Focus on “The 2nd International Symposium International Symposium on Acute Pulmonary Injury Translational Research organized by Hospital Universitario de Getafe, under the auspices of the: ‘INSPIRES®’.” edited d by Dr. Oscar Peñuelas and Dr. Jordi Rello

The objective of this issue of the journal is to present the main monographic reviews carried out by the speakers of the symposium to contribute to the dissemination of the current knowledge about the most relevant topics of ARDS, and the management and translational research of acute lung injury in critically ill patients requiring mechanical ventilation.

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Focus on “Advances in Cardiology, Interventional Cardiology, Electrophysiology, and Structural Heart Disease: A Moving Target” edited by Dr. Rami N. Khouzam

Cardiovascular disease, listed as the underlying cause of death, accounts for nearly 801,000 deaths in the US. This translates into 1 out of every 3 deaths in the US. About 2,200 Americans die of cardiovascular disease each day, an average of 1 death every 40 seconds. Cardiovascular diseases claim more lives each year than all forms of cancer and chronic lower respiratory disease combined. About 92.1 million American adults are living with some form of cardiovascular disease or the after-effects of stroke. Coronary heart disease is the leading cause (45.1%) of deaths attributable to cardiovascular disease in the US, followed by stroke (16.5%), heart failure (8.5%), high blood pressure (9.1%), diseases of the arteries (3.2%), and other cardiovascular diseases. Heart disease accounts for 1 in 7 deaths in the US. Cardiovascular disease is the leading global cause of death, accounting for more than 17.3 million deaths per year in 2013, a number that is expected to rise to over 23.6 million by 2030. In 2013, cardiovascular deaths represented 31% of all global deaths. In 2010, the estimated global cost of cardiovascular disease was $863 billion, and it is estimated to increase to $1,044 billion by 2030. Read More>>

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Focus on “Ethical Issues in Intensive Care” edited by Dr. Jean-Pierre Quenot and Dr. Jean-Philippe Rigaud

It is probably fair to say that most people never really think about the possibility that they may be admitted to an intensive care unit (ICU) in their life. Accordingly, the majority of ordinary people are not particularly knowledgeable about what exactly goes on in an ICU or what kind of care is dispensed there. In this context, for an ordinary person who experiences a serious health event requiring admission to the ICU, it can be an overwhelming, distressing experience. The environment is intimidating, the patient and/or family are bombarded with huge volumes of information that they don’t necessarily understand, or to which they are not receptive due to their stress about the sudden illness of a family member. This can initiate a vicious circle of poor knowledge, lack of information, difficult communication, which in turn can have repercussions for the healthcare team, who find the interactions difficult, and therefore more stressful. Read More>>

Focus on “Lower Extremity Arthroplasty” edited by Dr. Michael A. Mont

This special section of Annals of Translational Medicine focuses on important topics and techniques in total knee arthroplasty (TKA) and total hip arthroplasty (THA). It is not only meant for the orthopaedic audience, but also for the general readership who are interested in learning about the application of various surgical concepts. Therefore, we purposefully included studies evaluating a wide range of procedures and patient populations.

Focus on “Critical Care” edited by Drs. Ignacio Martin-Loeches and Saad Nseir

Severe sepsis is common in critically ill patients and is responsible for high mortality and morbidity. The aim of this special issue is to highlight recent advances in epidemiology, pathophysiology, diagnosis and treatment of sepsis in the critically ill patient.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

Sleep apnea is associated with worse outcomes following various kinds of surgeries. There is a paucity of data on the association of sleep apnea with clinical outcomes after transcatheter aortic valve replacement (TAVR).

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

Allenbach and colleagues have recently reported for the first time the results of an intriguing study of the histopathologic, immunopathologic and gene expression differences in muscle biopsy tissue from adult dermatomyositis (DM) patients who do and do not have circulating MDA5 autoantibodies (anti-MDA5). Anti-MDA5 were originally identified in a clinically-defined subset of DM patients whose disease was expressed predominately in the skin for unusually long periods of time without accompanying muscle weakness [i.e., “clinically-amyopathic DM” (CADM)] and were at risk for acute, rapidly-progressive form of interstitial lung disease (ILD)...

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Vol 6, No 7 (April, 2018)

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Focused Issues more

Focus on “Esophageal Cancer” More >>

Focus on “Lung Cancer Update 2017: from the test tube to the bed” More >>

Focus on “The 2nd International Symposium International Symposium on Acute Pulmonary Injury... More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Frailty in elderly ICU patients in Greece: a prospective, observational study

Dimitris Papageorgiou, Eleni Gika, Konstantina Kosenai, Konstantinos Tsironas, Lamprini Avramopoulou, Ervina Sela, Christina Mandila

PDF Full Text

Trends in total ankle arthroplasty and revisions in the Medicare database

Tsun Yee Law, Karim G. Sabeh, Samuel Rosas, Zachary Hubbard, Sarah Altajar, Martin W. Roche

PDF Full Text

Total knee replacement modifies the preoperative tibial torsion angle—similar results between computer-assisted and standard technique

Daniel Hernandez-Vaquero, Alfonso Noriega-Fernandez, Sergio Roncero-Gonzalez, Andres A. Sierra-Pereira, Manuel A. Sandoval-Garcia

PDF Full Text

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

PDF Full Text

No association between systemic complement activation and intensive care unit-acquired weakness

Esther Witteveen, Luuk Wieske, Friso M. de Beer, Nicole P. Juffermans, Camiel Verhamme, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn, on behalf of the BASIC study group

PDF Full Text

Review Article

Atherosclerosis as autoimmune disease

Petr Sima, Luca Vannucci, Vaclav Vetvicka

PDF Full Text

Esophagectomy with gastric conduit reconstruction for benign disease: extreme but important

Wei Guo, Su Yang, Hecheng Li

PDF Full Text

Case Report

Teeth infection may “shunt” through Fontan in high-altitude conditions

Juan D. Cano Sierra, Camilo F. Mestra, Juan C. Gelvez Nieto, Miguel Ronderos Dumit, Alberto García-Torres

PDF Full Text

Big-data Clinical Trial Column

Exploring heterogeneity in clinical trials with latent class analysis

Zhongheng Zhang, Abdallah Abarda, Ateka A. Contractor, Juan Wang, C. Mitchell Dayton

PDF Full Text

Estimate risk difference and number needed to treat in survival analysis

Zhongheng Zhang, Federico Ambrogi, Alex F. Bokov, Hongqiu Gu, Edwin de Beurs, Khaled Eskaf

PDF Full Text

Time-varying covariates and coefficients in Cox regression models

Zhongheng Zhang, Jaakko Reinikainen, Kazeem Adedayo Adeleke, Marcel E. Pieterse, Catharina G. M. Groothuis-Oudshoorn

PDF Full Text

Subgroup identification in clinical trials: an overview of available methods and their implementations with R

Zhongheng Zhang, Heidi Seibold, Mario V. Vettore, Woo-Jung Song, Vieille François

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Editorial of Column in Hypertension

Antihypertensive drug therapy

Wilbert S. Aronow

PDF Full Text

Editorial

Can pancreatitis be treated by inhibiting Ca²⁺ signaling?

John A. Williams, David I. Yule

PDF Full Text

To repair or to replace: four decades in the making

Patpilai Kasinpila, Y. Joseph Woo

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Increasing diagnostic yield by RNA-Sequencing in rare disease— bypass hurdles of interpreting intronic or splice-altering variants

Dong Li, Lifeng Tian, Hakon Hakonarson

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Inconclusive evidence to support the use of minimally-invasive radiofrequency denervation against chronic low back pain

Andreas A. Argyriou, Garifallia G. Anastopoulou, Jordi Bruna

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Improving CT screening for lung cancer with a highly predictive risk model

Cristiano Rampinelli, Marta Minotti

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SUSTAINable management of type 2 diabetes: feasibility of use and safety of semaglutide

Jun Shirakawa, Yasuo Terauchi

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition with evolocumab: powerful low-density lipoprotein cholesterol (LDL-C) lowering and improved cardiovascular outcomes without an increase in the risk of diabetes mellitus

Constantine E. Kosmas, Andreas Sourlas, Kyriaki V. Bouza, Eddy DeJesus, Delia Silverio, Peter D. Montan, Eliscer Guzman

PDF Full Text

Incretin-based therapy and pancreatitis: accumulating evidence and unresolved questions

Yoshifumi Saisho

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Perspective

Puzzle over active surveillance for micropapillary thyroid carcinoma

Hui Sun, Paolo Carcoforo, Gianlorenzo Dionigi

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Commentary

A critical electrocardiographic pattern in the age of cardiac biomarkers

Eduardo Matos Vilela, Francisco Sampaio, Tiago Dias, Ana Raquel Barbosa, João Primo, Daniel Caeiro, Marlene Fonseca, Vasco Gama Ribeiro

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Letter to the Editor

Histological examination of post-mortem brains of children with nodding syndrome

An Hotterbeekx, Sylvester Onzivua, Sonia Menon, Robert Colebunders

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Primary melanoma of the testis: myth

Francesco Fortarezza, Senia Maria Rosaria Trabucco, Annunziata De Luisi, Nicoletta Resta, Antonia Cimmino, Andrea Marzullo, Marco Moschetta, Teresa Lettini, Gabriella Serio

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Incorrect cell line validation and verification

Jaime A. Teixeira da Silva

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Review Articles

Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology

Antonio Franchitto, Paolo Onori, Anastasia Renzi, Guido Carpino, Romina Mancinelli, Domenico Alvaro, Eugenio Gaudio

The significance of genetics for cholangiocarcinoma development

Luca Maroni, Irene Pierantonelli, Jesus M. Banales, Antonio Benedetti, Marco Marzioni

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

The fetal liver as cell source for the regenerative medicine of liver and pancreas

Rossella Semeraro, Vincenzo Cardinale, Guido Carpino, Raffaele Gentile, Cristina Napoli, Rosanna Venere, Manuela Gatto, Roberto Brunelli, Eugenio Gaudio, Domenico Alvaro

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Lung cancer: biology and technology foster therapeutic innovation

Giannis Mountzios

Editorial

Aortic valve replacement in young patients: should the biological prosthesis be recommended over the mechanical?

Alberto Alperi, Daniel Hernandez-Vaquero, Isaac Pascual, Rocio Diaz, Iria Silva, Ruben Alvarez-Cabo, Pablo Avanzas, Cesar Moris

The choice of heart valve prosthesis for aortic valve replacement in the young: about choices and consequences

Thierry Bove

Bioprosthetic aortic valve replacement: a telltale from the young

Athanasios Antoniou, Amer Harky, John Yap, Kulvinder Kulvinder Lall, Mohamad Bashir

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Can we exonerate GLP-1 receptor agonists from blame for adverse pancreatic events?

Conor F. Murphy, Carel W. le Roux

Translating patient related outcome measures into practice— lessons to be learnt

Waseem Majeed, Hood Thabit

Does continuous glucose monitoring during pregnancy improve glycaemic and health outcomes in women with type 1 diabetes?— what the CONCEPTT trial adds

Diane Farrar, Matthew D. Campbell

Untangling the bilateral versus single internal mammary coronary artery bypass grafting debate

Emile Voisine, Pierre Voisine

Improved outcome of bilateral compared to single internal thoracic artery grafting: patient’s selection or technical skill?

Antonio M. Calafiore, Carlo Maria De Filippo, Massimiliano Foschi, Michele Di Mauro

BPI fold-containing family a member 2 as a biomarker of acute kidney injury—close but no (clinical) cigar?

Patrick M. Honore, David De Bels, Herbert D. Spapen

The role of glucagon-like peptide-1 receptor agonists in cardiovascular disease prevention in type 2 diabetes mellitus: evidence from the most recent clinical trials

S John Weisnagel

AdDIT Editorial comment—challenges in medication treatment of renal and cardiovascular diseases and risk factors in adolescents with type 1 diabetes

Fariba Ahmadizar, Anke H. Maitland-van der Zee

Pioglitazone and cardiovascular risk in T2DM patients: is it good for all?

Muhammad Abdul-Ghani, Amin Jayyous, Nidal Asaad, Sherif Helmy, Jassim Al-Suwaidi

Low-dose aspirin for primary cardiovascular prevention in diabetic patients: the issue to believe it or not

Priscilla Lamendola, Angelo Villano, Augusto Fusco, Massimo Leggio

Aspirin and diabetes mellitus in primary prevention: the Endless Conundrum

Rubén Casado-Arroyo

Anti-diabetic agents and heart health: how to use new diabetes medications in a global strategy for the prevention of cardiovascular complications in type 2 diabetes

Carmine Gazzaruso, Adriana Coppola, Tiziana Montalcini, Colomba Falcone

Quality of life and treatment satisfaction are highly relevant patient-reported outcomes in type 2 diabetes mellitus

Didac Mauricio

Review Article

Tidal volume in acute respiratory distress syndrome: how best to select it

Michele Umbrello, Antonella Marino, Davide Chiumello

Making progress in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer by surpassing resistance: third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs)

Giannis Mountzios

Treating ALK-positive non-small cell lung cancer

Dimitrios C. Ziogas, Anna Tsiara, Georgios Tsironis, Maria Lykka, Michalis Liontos, Aristotelis Bamias, Meletios-Athanasios Dimopoulos

The emerging treatment landscape of advanced non-small cell lung cancer

Panagiota Economopoulou, Giannis Mountzios

Breakthroughs in the treatment of advanced squamous-cell NSCLC: not the neglected sibling anymore?

Georgios Tsironis, Dimitrios C. Ziogas, Anastasios Kyriazoglou, Marita Lykka, Konstantinos Koutsoukos, Aristotelis Bamias, Meletios-Athanasios Dimopoulos

Implementation of immunotherapy in the treatment of advanced non-small cell lung cancer (NSCLC)

Anna Tsiara, Michalis Liontos, Maria Kaparelou, Roubini Zakopoulou, Aristotelis Bamias, Meletios-Athanasios Dimopoulos

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Immune checkpoint inhibitors and radiotherapy—concept and review of current literature

Loka Thangamathesvaran, Roshni Shah, Rebeka Verma, Omar Mahmoud

Quality in upper gastrointestinal endoscopic submucosal dissection

Flaminia Purchiaroni, Guido Costamagna, Cesare Hassan

Financial toxicity and implications for cancer care in the era of molecular and immune therapies

George Tran, S. Yousuf Zafar

Novel chemotherapy regimens for advanced lung cancer: have we reached a plateau?

Panagiotis Baxevanos, Giannis Mountzios

Chromatin remodeling defects in pediatric brain tumors

Alexia Klonou, Danai Spiliotakopoulou, Marios S. Themistocleous, Christina Piperi, Athanasios G. Papavassiliou

Advances on systemic treatment for lung neuroendocrine neoplasms

Nikolaos Tsoukalas, Panagiotis Baxevanos, Eleni Aravantinou-Fatorou, Maria Tolia, Michail Galanopoulos, Konstantinos Tsapakidis, George Kyrgias, Christos Toumpanakis, Gregory Kaltsas

Advanced small cell lung cancer (SCLC): new challenges and new expectations

Nikolaos Tsoukalas, Eleni Aravantinou-Fatorou, Panagiotis Baxevanos, Maria Tolia, Konstantinos Tsapakidis, Michail Galanopoulos, Michail Liontos, George Kyrgias

Molecular mechanisms of mechanotransduction in psoriasis

Lina S. Malakou, Antonios N. Gargalionis, Christina Piperi, Evangelia Papadavid, Athanasios G. Papavassiliou, Efthimia K. Basdra

Beyond EGFR and ALK: targeting rare mutations in advanced non-small cell lung cancer

Stavros Gkolfinopoulos, Giannis Mountzios

Original Article

Alcohol use disorders before and after bariatric surgery: a systematic review and meta-analysis

Hamza Azam, Sara Shahrestani, Kevin Phan

A technique of hand digit reconstruction using scarred and deformed donor segments

Nikolay M. Alexandrov, Michail G. Volovik, Denis V. Kiselev, Sergey V. Petrov

Monitoring of colonoscopy quality indicators in an academic endoscopy facility reveals adherence to international recommendations

Stefanos Karamaroudis, Aliki Stamou, Stamatia C. Vorri, Paraskevas Gkolfakis, Vasilios Papadopoulos, Georgios Tziatzios, Aikaterini Karagouni, Panagiota Katsouli, George D. Dimitriadis, Konstantinos Triantafyllou

Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders

Wilbert S. Aronow, Tatyana A. Shamliyan

Case Report

Abnormal chest X-ray leading to diagnosis of partial anomalous pulmonary venous connection

Zahava Farkas, Abbas Haidry, Srikanth Yandrapalli, Marc Lim, Diwakar Jain, Wilbert S. Aronow

Letter to the Editor

LAMP assays of Zika virus and other infectious agents will inevitably see expanded use due to their simplicity, sensitivity, specificity, and economy

Connie D. Brewster, Nunya Chotiwan, Rushika Perera, Sandra L. Quackenbush, Joel Rovnak

Sex and racial disparities in fractional flow reserve-guided percutaneous coronary intervention utilization: a 5-year national experience

Rupak Desai, Omer Mirza, Rajesh Sachdeva, Gautam Kumar

Positive correlation between TZAP and TERT in most cancers: a new player in cancer diseases

Yu-Ran Heo, Won-Jin Park, Jae-Ho Lee

Surgical Technique

Resection of esophageal diverticulum through uniportal video-assisted thoracoscopic surgery

Alfonso Fiorelli, Anna Cecilia Izzo, Ettore Arrigo, Francesco Sgalambro, Maria Antonietta Lepore, Massimo Cajozzo, Sergio Castorina, Attilio Ignazio Lo Monte, Mario Santini, Francesco Paolo Caroni