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ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

Focus on “Inborn Errors of Metabolism” edited by Dr. Shibani Kanungo and Dr. Dilip R. Patel

Annals of Translation Medicine (ATM) focused issue: inborn errors of metabolism (IEM) is a one stop resource for all levels of learners from undergraduates interested in science to multiple subspecialties in the field of medicine, genetics and public health.

Reading Companion: Blooming Flowers -A call for paper

Parent's Comments: Huilongwo was built in the Qing Dynasty. It is now a historic and cultural district in Xuzhou, in the center of the city. The old building in the painting is a corner of Huilongwo. Generally, children’s life experience lacks deeper nuances to understand the historical implications of architecture, in this painting, you can still see traces of tranquillity and vicissitudes. The usage of colors in this gives the old building vitality.

Focus on “Novel Aspects in Ventilator-associated Pneumonia” edited by Dr. Saad Nseir and Dr. Ignacio Martin-Loeches

Ventilator-associated pneumonia (VAP) remains an important clinical problem, being associated with significant morbidity and mortality. In this special issue of Annals of Translational Medicine, novel aspects regarding definition, diagnosis, epidemiology, and treatment of VAP are discussed by experts in this field.

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Focus on “Lower extremity arthroplasty” edited by Dr. Nipun Sodhi, Dr. Joseph O. Ehiorobo, Dr. Hiba K. Anis, Dr. Assem A. Sultan and Dr. Michael A. Mont.

This special section of Annals of Translational Medicine focuses on lower extremity arthroplasty, especially knee and hip pathologies. In this section, a multitude of pertinent topics for orthopaedic surgeons as well as for the general patient population are reviewed.

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” edited by Dr. Bo Li

Ever since an awareness of two distinct cultural conceptions of healthcare has emerged, the debate concerning whether evidence-based medicine and Traditional Chinese medicine (TCM) are incompatible or whether they can in fact be unified, has continued.

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Vol 7, No 9 (May, 2019)

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Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” More >>

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary

VCAM-1+ macrophage subset as ‘educators’ in fetal liver for transition to definitive hematopoiesis

Pranela Rameshwar

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Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke

Bernd Giebel, Dirk M. Hermann

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Inflammatory lymphadenopathy in renal cell carcinoma: prognostic tool?

Purnima Malhotra, Hemant Goel, Ashwani Kumar Mishra

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SELECTing adjuvant treatment in early stage epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer

Fabrizio Tabbò, Maria Lucia Reale, Enrico Ruffini, Silvia Novello, Francesco Guerrera

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Early-stage non-small cell lung cancer: the required type of resection (lobar vs. sublobar) remains unanswered

Natalie Baldes, Michael Eberlein, Servet Bölükbas

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Original Article

Effect of chromatic contrast on stereoacuity measurement with computer-aided three-dimensional technology

Lingzhi Zhao, Huang Wu

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The difference in stereoacuity testing: contour-based and random dot-based graphs at far and near distances

Lingzhi Zhao, Huang Wu

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Successful treatment of complex coronary chronic total occlusions improves midterm outcomes

Kai-Ze Wu, Ze-Han Huang, Zhi-An Zhong, Hong-Tao Liao, Yi Zhou, Bing-Zheng Luo, Mahesh Anantha-Narayanan, Rami N. Khouzam, Aakash Garg, Vladan Vukcevic, Nicholas G. Kounis, Bin Zhang, written on behalf of the AME Cardiovascular Disease Collaborative Group

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The relationship between preliminary efficacy and prognosis after first-line EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment of advanced non-small cell lung cancer

Dongfang Chen, Tianqing Chu, Qing Chang, Yanwei Zhang, Liwen Xiong, Rong Qiao, Jiajun Teng, Baohui Han, Runbo Zhong

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A randomized multicenter phase II trial of mecapegfilgrastim single administration versus granulocyte colony-stimulating growth factor on treating chemotherapy-induced neutropenia in breast cancer patients

Tao Wang, Biao Wu, Xichun Hu, Jinping Liu, Tao Zhang, Funian Li, Bing Sun, Li Cai, Xinzheng Li, Zhiyue Chen, Qing Yang, Zefei Jiang

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Dexmedetomidine versus midazolam and propofol for sedation in critically ill patients: Mining the Medical Information Mart for Intensive Care data

Yiyan Song, Shaowei Gao, Wulin Tan, Zeting Qiu, Huaqiang Zhou, Yue Zhao

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Long non-coding RNA IQCJ-SCHIP1 antisense RNA 1 is downregulated in colorectal cancer and inhibits cell proliferation

Jia Zhang, Zehua Bian, Guoying Jin, Yuhang Liu, Min Li, Surui Yao, Jing Zhao, Yuyang Feng, Xue Wang, Yuan Yin, Bojian Fei, Xiaofeng Han, Zhaohui Huang

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High-glucose treatment regulates biological functions of human umbilical vein endothelial cells via Sirt1/FOXO3 pathway

Yihui Chen, Yan Wang, Yaping Jiang, Xiaoyan Zhang, Minjie Sheng

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MARVELD1 attenuates arsenic trioxide-induced apoptosis in liver cancer cells by inhibiting reactive oxygen species production

Wenping Ma, Haiyang Shen, Qian Li, Hao Song, Yanyan Guo, Fangrong Li, Xingang Zhou, Xinwu Guo, Jingdong Shi, Qi Cui, Jinhao Xing, Jinhai Deng, Youtao Yu, Wenjie Liu, Hongshan Zhao

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Is waist circumference a negative predictor of calcaneal bone mineral density in adult Chinese men with normal weight?

Ling Chen, Jixing Liang, Junping Wen, Huibin Huang, Liantao Li, Wei Lin, Liyao Zong, Nengying Wang, Liangchun Cai, Kaka Tang, Hongjie Chen, Meizhi Li, Lixiang Lin, Jieli Lu, Yufang Bi, Weiqing Wang, Gang Chen

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Surgical management of pectus excavatum in China: results of a survey amongst members of the Chinese Association of Thoracic Surgeons

Ruiqing Shi, Liang Xie, Gang Chen, Qi Zeng, Xuming Mo, Jiming Tang, Haiyu Zhou, Dongkun Zhang, Xiong Ye, Zihao Zhou, Dan Tian, Cheng Deng, Xiaosong Ben, Guibin Qiao

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Review Article

Perineural invasion in cervical cancer: pay attention to the indications of nerve-sparing radical hysterectomy

Yi Zhu, Guo-Nan Zhang, Yu Shi, Ling Cui, Xue-Feng Leng, Jian-Ming Huang

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Immunity in cancer and atherosclerosis

Petr Sima, Luca Vannucci, Vaclav Vetvicka

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Case Report

A case of pseudomembranous tracheitis caused by Mycoplasma pneumoniae in an immunocompetent patient

Yong Hoon Lee, Hyewon Seo, Seung Ick Cha, Chang Ho Kim, Jaehee Lee

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Aggressive mycobacterium abscessus on repeated exogenous lipoid pneumonia in the right middle lobe

Bo Mi Gil, Myung Hee Chung, Young-Du Kim, Yong Hyun Kim, Hye Seon Kang, Il Jung Kim

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EGFR L718Q mutation occurs without T790M mutation in a lung adenocarcinoma patient with acquired resistance to osimertinib

Lei Ma, Rui Chen, Fang Wang, Li-Li Ma, Ming-Ming Yuan, Rong-Rong Chen, Jiang Liu

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Meet the Professor

Dr. Zhouqiao Wu: the magic of change

Chen Gao

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Tumors of the spine and spinal cord

Matthew L. Goodwin, Daniel M. Sciubba

Editorial

Lactate as a key metabolic intermediate in cancer

L. Bruce Gladden

Review Article

Cerebrospinal fluid leaks after spine tumor resection: avoidance, recognition and management

Sean M. Barber, Jared S. Fridley, Sanjay Konakondla, Jonathan Nakhla, Adetokunbo A. Oyelese, Albert E. Telfeian, Ziya L. Gokaslan

Systematic review on the utility of magnetic resonance imaging for operative management and follow-up for primary sarcoma—lessons from extremity sarcomas

Zach Pennington, A. Karim Ahmed, Ethan Cottrill, Erick M. Westbroek, Matthew L. Goodwin, Daniel M. Sciubba

Lactate and cancer: spinal metastases and potential therapeutic targets (part 2)

Zach Pennington, Matthew L. Goodwin, Erick M. Westbroek, Ethan Cottrill, A. Karim Ahmed, Daniel M. Sciubba

Total en bloc resection of primary and metastatic spine tumors

Elizabeth P. Howell, Theresa Williamson, Isaac Karikari, Muhammad Abd-El-Barr, Melissa Erickson, Matthew L. Goodwin, Jeremy Reynolds, Daniel M. Sciubba, C. Rory Goodwin

Lactate and cancer: a “lactatic” perspective on spinal tumor metabolism (part 1)

Matthew L. Goodwin, Zach Pennington, Erick M. Westbroek, Ethan Cottrill, A. Karim Ahmed, Daniel M. Sciubba

The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer

Udit Chaddha, D. Kyle Hogarth, Septimiu Murgu

Liquid biopsy for lung cancers: an update on recent developments

Alberto E. Revelo, Alvaro Martin, Ricardo Velasquez, Prarthna Chandar Kulandaisamy, Jean Bustamante, Sevak Keshishyan, Gregory Otterson

Placement of markers to assist minimally invasive resection of peripheral lung lesions

Ricardo Velasquez, Alvaro Martin, Mohammad Abu Hishmeh, Lawrence DeLorenzo, Samjot Singh Dhillon, Kassem Harris

Innovations in functional and rehabilitative knee bracing

Jim Hewlett, John Kenney

Diagnosis and management of peripheral lung nodule

Taha Khan, Yasir Usman, Tony Abdo, Fawad Chaudry, Jean I. Keddissi, Houssein A. Youness

Pros and cons of different ways to address dysfunctional autophagy in Pompe disease

Jeong-A Lim, Naresh Kumar Meena, Nina Raben

Anesthetic considerations for lung resection: preoperative assessment, intraoperative challenges and postoperative analgesia

Debra Lederman, Jasmeet Easwar, Joshua Feldman, Victoria Shapiro

Contemporary approach to the patient with malignant pleural effusion complicating lung cancer

Oleg Epelbaum, Najib M. Rahman

Molecular genetics of Pompe disease: a comprehensive overview

Paolo Peruzzo, Eleonora Pavan, Andrea Dardis

Challenges in treating Pompe disease: an industry perspective

Hung V. Do, Richie Khanna, Russell Gotschall

An emerging phenotype of central nervous system involvement in Pompe disease: from bench to bedside and beyond

Aditi Korlimarla, Jeong-A Lim, Priya S. Kishnani, Baodong Sun

Molecular foundations of primary spinal tumors—implications for surgical management

Tej D. Azad, Bowen Jiang, Chetan Bettegowda

Prognostic models for spinal metastatic disease: evolution of methodologies, limitations, and future opportunities

Aditya V. Karhade, John H. Shin, Joseph H. Schwab

Advances in personalized treatment of metastatic spine disease

Pouyan Ahangar, Mina Aziz, Derek H. Rosenzweig, Michael H. Weber

Restoring the regenerative balance in neuromuscular disorders: satellite cell activation as therapeutic target in Pompe disease

Gerben J. Schaaf, Rodrigo Canibano-Fraile, Tom J. M. van Gestel, Ans T. van der Ploeg, WWM Pim Pijnappel

Review of robotic-assisted surgery: what the future looks like through a spine oncology lens

Arash J. Sayari, Coralie Pardo, Bryce A. Basques, Matthew W. Colman

Endpoint surrogacy in oncological randomized controlled trials with immunotherapies: a systematic review of trial-level and arm-level meta-analyses

Jianrong Zhang, Wenhua Liang, Hengrui Liang, Xiaofei Wang, Jianxing He

Long-term outcome and unmet needs in infantile-onset Pompe disease

Andreas Hahn, Anne Schänzer

Management of hemoptysis in patients with lung cancer

Evgeni Gershman, Rachel Guthrie, Kevin Swiatek, Samira Shojaee

Postobstructive pneumonia in lung cancer

Aashish Valvani, Alvaro Martin, Anusha Devarajan, Dipak Chandy

Progress and challenges of gene therapy for Pompe disease

Giuseppe Ronzitti, Fanny Collaud, Pascal Laforet, Federico Mingozzi

Anesthetic management during bronchoscopy of patients with pulmonary hypertension

Jason Broker, Draginja Cvetkovic, Saman Yaghoubian

Treatment, complications, and outcomes of metastatic disease of the spine: from Patchell to PROMIS

Alexander T. Yahanda, Jacob M. Buchowski, Adam M. Wegner

Role of bronchoscopy in management of central squamous cell lung carcinoma in situ

Ankit Gupta, Kassem Harris, Samjot Singh Dhillon

Management of air leaks post-surgical lung resection

Matthew E. Bronstein, Donna C. Koo, Tracey L. Weigel

The use of tranexamic acid in spine surgery

Joon S. Yoo, Junyoung Ahn, Sailee S. Karmarkar, Eric H. Lamoutte, Kern Singh

Cytokines expression levels from tissue, plasma or serum as promising clinical biomarkers in adenocarcinoma of the prostate: a systematic review of recent findings

Jagtar Singh, Sukhwinder Singh Sohal, Aijye Lim, Henry Duncan, Thanuja Thachil, Paolo De Ieso

Original Article

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI

Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models

John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann

Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging

Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric K. Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael

Random forest can accurately predict the development of end-stage renal disease in immunoglobulin a nephropathy patients

Xin Han, Xiaonan Zheng, Ying Wang, Xiaoru Sun, Yi Xiao, Yi Tang, Wei Qin

Tumor location is an independent prognostic factor of esophageal adenocarcinoma based on the eighth edition of TNM staging system in Chinese patients

Han-Yu Deng, Xi Zheng, Guha Alai, Gang Li, Jun Luo, Ze-Guo Zhuo, Yi-Dan Lin

Intra- and interobserver reliability of the Spinal Instability Neoplastic Score system for instability in spine metastases: a systematic review and meta-analysis

Zach Pennington, A. Karim Ahmed, Ethan Cottrill, Erick M. Westbroek, Matthew L. Goodwin, Daniel M. Sciubba

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Astym^® therapy improves FOTO^® outcomes for patients with musculoskeletal disorders: an observational study

Leah S. Harris, Suzanne Freeman, Ying-Chih Wang

Assessing metabolic profiles in human myoblasts from patients with late-onset Pompe disease

Peter Meinke, Sarah Limmer, Stefan Hintze, Benedikt Schoser

Malnutrition in patients who underwent surgery for spinal metastases

Anne L. Versteeg, Floris R. van Tol, Mechteld A. Lehr, Cumhur F. Oner, Jorrit-Jan Verlaan

Clinical presentation, management and outcomes of sacral metastases: a multicenter, retrospective cohort study

Raphaële Charest-Morin, Charles G. Fisher, Ann L. Versteeg, Arjun Sahgal, Peter Pal Varga, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Michelle J. Clarke, Laurence D. Rhines, Stefano Boriani, Chetan Bettegowda, Michael G. Fehlings, Paul M. Arnold, Ziya L. Gokaslan, Nicolas Dea

Salvage lymphadenectomy for isolated cervical lymph node recurrence after curative resection of thoracic esophageal squamous cell carcinoma

Zhen Wang, Shaofeng Lin, Feng Wang, Shuoyan Liu

Both silicalite-1/SiC foam and ZSM-5/SiC foam may serve as novel bone replacement materials

Fengyu Hao, Cuicui Zhang, Lin Wu, Yong Gao, Yilai Jiao

Modification of the tumor response threshold in patients of advanced non-small cell lung cancer treated with chemotherapy plus targeted agents: a pooled study from five clinical trials in one institution

Fan Luo, Zhonghan Zhang, Kunlun Liao, Yang Zhang, Yuxiang Ma, Zhihuang Hu, Kangmei Zeng, Yan Huang, Li Zhang, Hongyun Zhao

In-hospital outcomes of inflammatory bowel disease in cannabis users: a nationwide propensity-matched analysis in the United States

Rupak Desai, Upenkumar Patel, Hemant Goyal, Afrina Hossain Rimu, Dipen Zalavadia, Pardeep Bansal, Nihar Shah

Perioperative sedative use is not associated with acute kidney injury after total hip or knee arthroplasty

Tak Kyu Oh, Jin-Woo Park, Hyun-Jung Shin, Hyo-Seok Na, Ah-Young Oh, Jung-Won Hwang

Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds

Lan Li, Yixuan Li, Longfei Yang, Fei Yu, Kaijia Zhang, Jing Jin, Jianping Shi, Liya Zhu, Huixin Liang, Xingsong Wang, Qing Jiang

The effect of extension assist orthosis with pneumatic bladders on pain and function for patients with early knee osteoarthritis

Kathleen Madara, Moiyad Aljehani, Federico Pozzi, Elizabeth Colonna, Joseph A. Zeni Jr

Outcomes and cost-minimization analysis of cement spacers versus expandable cages for posterior-only reconstruction of metastatic spine corpectomies

Yusef Jordan, Jacob M. Buchowski, Mahati Mokkarala, Colleen Peters, David B. Bumpass

Clinical and prognostic significance of combined plasma fibrinogen concentrations and the monocyte-to-lymphocyte ratio in patients with ovarian cancer

Yuanyuan Cao, Xiuwen Ni, Yong Wang, Lejian Wang, Kai Yuan, Guofang Gan, Kunming x Kunming Zhang, Zhidi Zhao, Xianming Fei

Imaging phenotype using radiomics to predict dry pleural dissemination in non-small cell lung cancer

Minglei Yang, Yijiu Ren, Yunlang She, Dong Xie, Xiwen Sun, Jingyun Shi, Guofang Zhao, Chang Chen

FK506 prevented bone loss in streptozotocin-induced diabetic rats via enhancing osteogenesis and inhibiting adipogenesis

Li-Hua Ni, Ri-Ning Tang, Cheng Yuan, Kai-Yun Song, Li-Ting Wang, Xiao-Chen Wang, Yu-Xia Zhang, Xiao-Liang Zhang, Dong-Dong Zhu, Bi-Cheng Liu

The molecular epidemiology of hyperphenylalaninemia in Uygur population: incidence from newborn screening and mutational spectra

Yajie Su, Huijun Wang, Nuerya Rejiafu, Bingbing Wu, Haili Jiang, Hongbo Chen, Xian A, Yanyan Qian, Mingzhu Li, Yulan Lu, Yan Ren, Long Li, Wenhao Zhou

Case Report

Management of presacral schwannomas—a 10-year multi-institutional series

Zach Pennington, Clemens Reinshagen, A. Karim Ahmed, Sean Barber, Matthew L. Goodwin, Ziya Gokaslan, Daniel M. Sciubba

Seronegative atypical anti-glomerular basement membrane crescentic glomerulonephritis

Sreedhar Adapa, Venu Madhav Konala, Jean Hou, Srikanth Naramala, Nikhil Agrawal, Hemant Dhingra, Wilbert S. Aronow

All-posterior total en bloc spondylectomy for thoracic spinal tumors

Philip K. Louie, Jannat M. Khan, Ira Miller, Matthew W. Colman

Bronchoscopic instillation of DNase to manage refractory lobar atelectasis in a lung cancer patient

Hussein Assallum, Tian Yue Song, Lawrence DeLorenzo, Kassem Harris

Pleomorphic carcinoma of the lung: from thin-walled cavity to solid tumor

Yanbo Yang, Jiandong Mei, Feng Lin

Letter to the Editor

Discrepancy between theory and practice of the clinical tumor-nodes-metastasis (TNM) classification for localized prostate cancer

Jan Herden, Christian Wittekind, Lothar Weissbach

Surgical Technique

Extracorporeal radiation and reimplantation: a safe and viable option for reconstruction after sacral tumor resection?

Matthew L. Goodwin, Manit K. Gundavda, Rajeev Reddy, Kedar Deogaonkar, Murad Lala, Amresh Baliarsing, Daniel M. Sciubba, Kevin B. Jones, Manish Agarwal

Editorial Commentary

Immunotherapy for head and neck cancer: where are we now and where are we going?

Joshua M. Bauml, Charu Aggarwal, Roger B. Cohen

Combining immunotherapy and epidermal growth factor receptor kinase inhibitors: worth the risk?

Hira Latif, Stephen V. Liu

Renal function after kidney surgery: “it’s tough to make predictions, especially about the future”

John M. DiBianco, Patrick T. Gomella, Mark W. Ball

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Depth of invasion for prognostic stratification in oral cavity cancer: do we need further validation?

Cesare Piazza, Lorenzo Bresciani, Lorenzo Giannini

Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products

Peter A. D. Wellham, Dong-Hyun Kim, Matthias Brock, Cornelia H. de Moor

Editorial commentary: the multiligament injured knee: current controversies and strategies for improving outcomes

Adnan Saithna

Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

Quante Singleton, Santul Bapat, Sadanand Fulzele

Brain metastases in EGFR-positive non-small cell lung cancer: the way to the sanctuary becomes less winding

Antonio Passaro, Letizia Gianoncelli, Valeria Stati, Filippo de Marinis

Asymmetric dimethylarginine, erythropoietin resistance, and anemia in CKD

Tammy L. Sirich, Glenn M. Chertow

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

New insights into cordycepin production in Cordyceps militaris and applications

Sunita Chamyuang, Amorn Owatworakit, Yoichi Honda

The role of acute kidney injury duration in clinical practice

Chyi-Sheng Khor, Wei-Jie Wang

Current landscape of cytoreductive nephrectomy: who, when, and why?

Jiping Zeng, Alfredo Harb-De la Rosa, Juan Chipollini

Improving patient selection for adjuvant therapy in high-risk renal cell carcinoma

Dylan M. Buller, Benjamin T. Ristau

Risk reduction in kidney surgery

Martin Marszalek

An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution

Lykourgos-Panagiotis Zalmas, Wei-Ting Lu, Nnennaya Kanu

The role of laparoscopic pancreaticoduodenectomy—how take care of patient security?

Trond A. Buanes

Pembrolizumab plus ipilimumab or pegylated interferon alfa-2b for patients with melanoma or renal cell carcinoma: take new drugs but keep the old?

Matthew Zibelman, Elizabeth R. Plimack

State of the art in multiligament knee injuries: from diagnosis to treatment

Marcel Faraco Sobrado

Revisiting the role of lymph node dissection in renal cell carcinoma

Alice Yu, Dimitar V. Zlatev, Michael L. Blute Sr

Lack of evidence regarding bone metastases of genitourinary cancers: interventions by surgery, radiotherapy, and bone-targeted systemic therapy

Makito Miyake, Takuya Owari, Kiyohide Fujimoto

Cellular therapy for autism spectrum disorder: a step forward to the optimal treatments

Dario Siniscalco, Nicola Antonucci

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Stereotactic body radiation therapy for oligometastatic renal cell carcinoma: improving outcomes in an otherwise radioresistant malignancy

Thomas H. Beckham, Brandon S. Imber, Charles B. Simone II

Smoking favours hepatocellular carcinoma

Maria Guarino, Jean-François Dufour

Predicting mortality after postcardiotomy venoarterial extracorporeal membrane oxygenation

Fausto Biancari, Angelo M. Dell’Aquila, Giovanni Mariscalco

Stereotactic body radiation therapy could improve disease control in oligometastatic patients with renal cell carcinoma: do we need more evidence?

Linda Agolli

Role of stereotactic body radiation therapy for the management of renal cell carcinoma: tailoring treatment in the era of the “embarrassment of riches”

Sebastiano Buti, Alessandro Leonetti, Elisabetta Lattanzi, Nunziata D’Abbiero, Melissa Bersanelli

Microfracture for cartilage repair in the knee: current concepts and limitations of systematic reviews

Sang Jun Song, Cheol Hee Park

Lobar or sublobar resections are safe procedures for management of early lung cancer

Alfonso Fiorelli, Immacolata Mauro, Gaetano Cicchitto, Aldo Prencipe, Mario Polverino, Vincenzo Giuseppe Di Crescenzo, Mario Santini

Comment on an external validation of the 8th edition of the TNM classification for lung cancer staging in patients treated with chemoradiation

Ramón Palmero, Arturo Navarro-Martin, Ernest Nadal

TNM in non-small cell lung cancer: a staging system for all oncologists or just for surgeons?

David Ball

Behaviorally associated changes in neuroconnectivity following autologous umbilical cord blood infusion in young children with autism spectrum disorder

Richard E. Frye

Is the adipose-derived mesenchymal stem cell therapy effective for treatment of knee osteoarthritis?

Ilaria Roato, Riccardo Ferracini

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A 7.0–7.7% value for glycated haemoglobin is better than a <7% value as an appropriate target for patient-centered drug treatment of type 2 diabetes mellitus

José Pedro L. Nunes, Joseph P. DeMarco

Immune checkpoint inhibitors for esophageal cancer: are we moving in the right direction?

Alexander G. Raufi, Khaldoun Almhanna

Non-small cell lung cancer 2 cm or less: robotic segmentectomy sets the gold standard against non-surgical therapy

Dana Ferrari-Light, Robert J. Cerfolio

Reconsider minimally invasive surgery for early cervical cancer

Yi Zhang, Shuguang Chen

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.