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ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

Focus on “Wilson’s disease: From Genetics to Management of Disease” edited by Dr. Ralf Weiskirchen and Dr. Wolfgang Stremmel

In this focused issue “Wilson Disease: From Genetics to Management of Disease”, leading experts working in the field of Wilson disease have summarized recent findings and advances in our understanding of this copper overload disease in regard to experimental and clinical aspects. The present knowledge on genetics and pathophysiology in relation to diagnostic and therapeutic procedures is our special interest. Challenges in diagnosis, anti-copper therapies, and clinical practice guidelines will be discussed.

Focused Issue on Current Trends and Advancements in Spine Surgery

This focused isuse on “Current Trends and Advancements in Spine Surgery” is edited by Dr. Kern Singh, from Department of Orthopaedic Surgery, Rush University Medical Center, Co-Director Minimally Invasive Spine Institute, USA

Focused Issue on Strategies to Achieve Long-term Success of Lung Transplantation

This focused issue on “Strategies to Achieve Long-term Success of Lung Transplantation is edited by Dr. Masaaki Sato and Dr. Dong Tian, Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Focused Issue on Stem Cell and Clinical Application

This focusedissue on “Stem Cell and Clinical Application” is edited by Dr. Ling Lu, fromDivision of Liver Surgery, the First Affiliated Hospital of Nanjing MedicalUniversity, Nanjing, China

Focused Issue on The Immature Spine

This focused issue is edited by Dr. Federico Canavese, from Department of Pediatric Orthopedic Surgery, University Hospital Estaing, 1 place Lucie et Raymond Aubrac, Clermont Ferrand 63003, France.

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease

This focused issue on “Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease” is edited by Dr. Rami Khouzam, Professor of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Focus on “Spinal Tumor Surgery” edited by Dr. Matthew L. Goodwin and Dr. Daniel M. Sciubba

This special issue of Annals of Translational Medicine focuses on tumors in and around the spine. The field of spine tumor surgery is undergoing a transition period, as multidisciplinary care of the patient with the spinal tumor has become the standard of care.

Focus on: “Application of Artificial Intelligence to Radiology” edited by Dr. Timothy Deyer and Dr. Amish Doshi

In this focused issue of the Annals of Translational Medicine “Application of Artificial Intelligence to Radiology”, we explore the use of AI in to specific clinical and operational problems in Radiology.

Focus on “Pompe Disease” edited by Dr. Rosa Puertollano and Dr. Nina Raben

In this special issue of Annals of Translational Medicine, well distinguished clinicians, academic researchers, industry scientists, and patient advocates address recent advances and challenges in current and future therapies for Pompe disease, a prototypical lysosomal storage disorder. As is the case with many maladies, the history of Pompe disease, a severe neuromuscular disorder, is a reflection of the accelerating pace of basic science discoveries and the speed with which scientific knowledge is translated into medical progress.

ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

ATM New Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that, effective June 2019, Dr. Yinghao Sun will be taking over as co-the Editor-in-Chief in tandem with Dr. Xuehao Wang and Dr. Jianxing He.

Dr. Yinghao Sun is a Chief Physician, PhD Supervisor, an Academician of the Chinese Academy of Engineering, the Chief Scientist of 973 programs, and the winner of Ho Leung Ho Lee Foundation Award. He is currently the President of the Second Military Medical University, and he is the Director of the Department of Urology. He is also the Director of the Research Institute for Prostatic Disease of the PLA, and the Director of Changhai da Vinci Robotic Surgery Training Center. Dr. Sun specializes in clinical diagnosis, treatment, and research of urological tumors and urolithiasis, as well as practice and innovate techniques for minimally invasive urological techniques.

ATM New Honorary Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that Dr. Rafael Rosell, former Editor-in-Chief of the journal, will continuously serve on the editorial board as the Honorary Editor-in-Chief from June 2019.

First of all, we would like to sincerely thank Dr. Rafael Rosell for his hard work and dedication since 2015, without which the journal would not be the success it is today.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Focus on “Lower extremity arthroplasty” edited by Dr. Nipun Sodhi, Dr. Joseph O. Ehiorobo, Dr. Hiba K. Anis, Dr. Assem A. Sultan and Dr. Michael A. Mont.

This special section of Annals of Translational Medicine focuses on lower extremity arthroplasty, especially knee and hip pathologies. In this section, a multitude of pertinent topics for orthopaedic surgeons as well as for the general patient population are reviewed.

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” edited by Dr. Bo Li

Ever since an awareness of two distinct cultural conceptions of healthcare has emerged, the debate concerning whether evidence-based medicine and Traditional Chinese medicine (TCM) are incompatible or whether they can in fact be unified, has continued.

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Vol 7, No 15 (August, 2019)

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Meet The Professor more

Dr. Zhouqiao Wu: the magic of change More >>

Experience in article writing about academic research and social issues More >>

Prof. Bin Zhang: no pains, no gains More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Preface

Focused issue on diagnosis and management of lung cancer patients

Kassem Harris, Samjot Singh Dhillon

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Review Article

Diagnosis and management of peripheral lung nodule

Taha Khan, Yasir Usman, Tony Abdo, Fawad Chaudry, Jean I. Keddissi, Houssein A. Youness

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Liquid biopsy for lung cancers: an update on recent developments

Alberto E. Revelo, Alvaro Martin, Ricardo Velasquez, Prarthna Chandar Kulandaisamy, Jean Bustamante, Sevak Keshishyan, Gregory Otterson

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Point of care ultrasound in thoracic malignancy

Matthew J. Miles, Shaheen Islam

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The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer

Udit Chaddha, D. Kyle Hogarth, Septimiu Murgu

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Contemporary approach to the patient with malignant pleural effusion complicating lung cancer

Oleg Epelbaum, Najib M. Rahman

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Malignant pleural effusion and cancer of unknown primary site: a review of literature

Saed Fathi Awadallah, Mark R. Bowling, Nitika Sharma, Arjun Mohan

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Role of bronchoscopy in management of central squamous cell lung carcinoma in situ

Ankit Gupta, Kassem Harris, Samjot Singh Dhillon

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Anesthetic management during bronchoscopy of patients with pulmonary hypertension

Jason Broker, Draginja Cvetkovic, Saman Yaghoubian

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Anesthetic considerations for lung resection: preoperative assessment, intraoperative challenges and postoperative analgesia

Debra Lederman, Jasmeet Easwar, Joshua Feldman, Victoria Shapiro

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Postobstructive pneumonia in lung cancer

Aashish Valvani, Alvaro Martin, Anusha Devarajan, Dipak Chandy

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Management of hemoptysis in patients with lung cancer

Evgeni Gershman, Rachel Guthrie, Kevin Swiatek, Samira Shojaee

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Paraneoplastic syndromes in lung cancer and their management

Asad Anwar, Firas Jafri, Sara Ashraf, Mohammad Ali S. Jafri, Michael Fanucchi

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Placement of markers to assist minimally invasive resection of peripheral lung lesions

Ricardo Velasquez, Alvaro Martin, Mohammad Abu Hishmeh, Lawrence DeLorenzo, Samjot Singh Dhillon, Kassem Harris

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Management of air leaks post-surgical lung resection

Matthew E. Bronstein, Donna C. Koo, Tracey L. Weigel

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Bronchoscopic ablation techniques in the management of lung cancer

Ray W. Shepherd, Christopher Radchenko

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Case Report

Bronchoscopic instillation of DNase to manage refractory lobar atelectasis in a lung cancer patient

Hussein Assallum, Tian Yue Song, Lawrence DeLorenzo, Kassem Harris

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Anticoagulation, catheterization, and minimizing intervention: how cutting-edge cuts down disease

Rami N. Khouzam

Editorial

Physician-owned hospitals in orthopedic and spine surgery

Junyoung Ahn, Scott Blumenthal, Peter B. Derman

Improving our understanding of breast cancer tumorigenesis across ethnicities

Michael J. McKay, Melissa Southey

Review Article

Innovations in functional and rehabilitative knee bracing

Jim Hewlett, John Kenney

The use of tranexamic acid in spine surgery

Joon S. Yoo, Junyoung Ahn, Sailee S. Karmarkar, Eric H. Lamoutte, Kern Singh

Evidence based treatment options for common knee injuries in runners

Simeon Mellinger, Grace Anne Neurohr

Changing reimbursement models and private equity ownership in spine surgery

Matthew S. Galetta, Heeren S. Makanji, John Strony, Dhruv K. C. Goyal, Mark F. Kurd

Immunotherapy and targeted therapy—the new roadmap in cancer treatment

Kamran Shahid, Mustafa Khalife, Raetasha Dabney, Alexandria Phan

The utility of virtual reality and augmented reality in spine surgery

Joon S. Yoo, Dillon S. Patel, Nadia M. Hrynewycz, Thomas S. Brundage, Kern Singh

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Post-operative atrial fibrillation: should we anticoagulate?

Pooja S. Jagadish, Irene Kirolos, Sarthak Khare, Aranyak Rawal, Victor Lin, Rami N. Khouzam

An evaluation of biomaterials and osteobiologics for arthrodesis achievement in spine surgery

Joon S. Yoo, Junyoung Ahn, Dillon S. Patel, Nadia M. Hrynewycz, Thomas S. Brundage, Kern Singh

Static progressive stretch orthosis—consensus modality to treat knee stiffness—rationale and literature review

Anil Bhave, Nipun Sodhi, Hiba K. Anis, Joseph O. Ehiorobo, Michael A. Mont

Is early invasive management as ST elevation myocardial infarction warranted in de Winter’s sign?—a “peak” into the widow-maker

Joel M. Raja, Amit Nanda, Issa Pour-Ghaz, Rami N. Khouzam

Accuracy of non-invasive and minimally invasive hemodynamic monitoring: where do we stand?

Issa Pour-Ghaz, Theodore Manolukas, Nathalie Foray, Joel Raja, Aranyak Rawal, Uzoma N. Ibebuogu, Rami N. Khouzam

Pharmacologic therapy of obesity: mechanisms of action and cardiometabolic effects

Peter D. Montan, Andreas Sourlas, Jiohanna Olivero, Delia Silverio, Eliscer Guzman, Constantine E. Kosmas

Serological biomarkers for acute mesenteric ischemia

Obulkasim Memet, Lin Zhang, Jie Shen

Apple Watch, Wearables, and Heart Rhythm: where do we stand?

Joel Mukesh Raja, Carol Elsakr, Sherif Roman, Brandon Cave, Issa Pour-Ghaz, Amit Nanda, Miguel Maturana, Rami N. Khouzam

Transcatheter aortic valve replacement with a focus on transcarotid: a review of the current literature

Issa Pour-Ghaz, Joel Raja, Mahmoud Bayoumi, Theodore Manolukas, Rami N. Khouzam, Uzoma N. Ibebuogu

Ticagrelor or prasugrel vs. clopidogrel in combination with anticoagulation for treatment of acute coronary syndrome in patients with atrial fibrillation

Irene Kirolos, Ikechukwu Ifedili, Miguel Maturana, Alykhan Moez Premji, Brandon Cave, Sherif Roman, David Jones, Romany Gaid, Yehoshua C. Levine, Sunil Jha, Rajesh Kabra, Rami N. Khouzam

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Endoscopic transforaminal lumbar interbody fusion without general anesthesia: technical innovations and outcomes

John Paul G. Kolcun, G. Damian Brusko, Michael Y. Wang

Concise update on colorectal cancer epidemiology

Camilla Mattiuzzi, Fabian Sanchis-Gomar, Giuseppe Lippi

Steroids in pediatric acute respiratory distress syndrome

Nicolás Monteverde-Fernández, Federico Cristiani, Jenniffer McArthur, Sebastián González-Dambrauskas

CardioMEMS: where we are and where can we go?

Issa Pour-Ghaz, David Hana, Joel Raja, Uzoma N. Ibebuogu, Rami N. Khouzam

The dilemma of aspirin resistance in obese patients

Devarshi Ardeshna, Sarthak Khare, Pooja S. Jagadish, Venugopal Bhattad, Brandon Cave, Rami N. Khouzam

Current status of oral anticoagulant reversal strategies: a review

Aranyak Rawal, Devarshi Ardeshna, Sheharyar Minhas, Brandon Cave, Uzoma Ibeguogu, Rami Khouzam

Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events

Venugopal B. Bhattad, Sathvika Gaddam, Margaret A. Lassiter, Pooja S. Jagadish, Devarshi Ardeshna, Brandon Cave, Rami N. Khouzam

Red flag rules for knee and lower leg differential diagnosis

Young Jae Kim

Action plan for improving cardiac rehabilitation-related outcomes in a university hospital based on a review of previous interventions

Carol Elsakr, Leesa Wright, Pooja S. Jagadish, David A. Bulger, Uzoma N. Ibebuogu, Rami N. Khouzam

Original Article

Tumor location is an independent prognostic factor of esophageal adenocarcinoma based on the eighth edition of TNM staging system in Chinese patients

Han-Yu Deng, Xi Zheng, Guha Alai, Gang Li, Jun Luo, Ze-Guo Zhuo, Yi-Dan Lin

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Astym^® therapy improves FOTO^® outcomes for patients with musculoskeletal disorders: an observational study

Leah S. Harris, Suzanne Freeman, Ying-Chih Wang

The effect of extension assist orthosis with pneumatic bladders on pain and function for patients with early knee osteoarthritis

Kathleen Madara, Moiyad Aljehani, Federico Pozzi, Elizabeth Colonna, Joseph A. Zeni Jr

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Preoperative D-dimer level is an independent prognostic factor for non-small cell lung cancer after surgical resection: a systematic review and meta-analysis

Han-Yu Deng, Xi Zheng, Rui Jiang, Rui-Lan Wang, Jie Zhou, Xiao-Ming Qiu

Postoperative albumin-bilirubin grade and albumin-bilirubin change predict the outcomes of hepatocellular carcinoma after hepatectomy

Linsen Ye, Rongpu Liang, Jiebin Zhang, Chaojin Chen, Xiaolong Chen, Yi Zhang, Guoying Wang, Yang Yang, Guihua Chen

Non-operative treatment options for knee osteoarthritis

Michael DeRogatis, Hiba K. Anis, Nipun Sodhi, Joseph O. Ehiorobo, Morad Chughtai, Anil Bhave, Michael A. Mont

Two novel mutations of PEX6 in one Chinese Zellweger spectrum disorder and their clinical characteristics

Hui-Ling Yu, Yan Shen, Yi-Min Sun, Yue Zhang

Effects of GLP-1 receptor analogue liraglutide and DPP-4 inhibitor vildagliptin on the bone metabolism in ApoE^−/− mice

Lizhi Zhang, Peicheng Li, Zhaosheng Tang, Qin Dou, Bo Feng

Are management decisions in critical patients changed with use of hemodynamic parameters from transpulmonary thermodilution technique?

Ye Rim Chang, Seok Ho Choi, Sung Wook Chang

Chin-down-plus-larynx-tightening maneuver improves choking cough after esophageal cancer surgery

Yongkui Yu, Yin Li, Yingmin Lu, Xionghuai Hua, Haibo Ma, Haomiao Li, Xiufeng Wei, Jun Zhang, Xiankai Chen, Qi Liu, Zhengshuai Zhu, Lei Xu, Ruixiang Zhang, Haibo Sun, Zongfei Wang

Clinical characteristics and management of cardiac and/or pulmonary cement embolus after percutaneous vertebroplasty: a single center experience

Min Kong, Xinjian Xu, Jianfei Shen, Qiang Liu, Gongchao Wang

Differential diagnosis between lymphoma-associated malignant pleural effusion and tuberculous pleural effusion

Chang Ho Kim, Hong Geun Oh, Sang Yub Lee, Jae Kwang Lim, Yong Hoon Lee, Hyewon Seo, Seung Soo Yoo, Shin Yup Lee, Seung Ick Cha, Jae Yong Park, Jaehee Lee

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Prognostic significance and role of thoracic lymph node metastasis based on Chinese expert consensus in esophageal cancer

Qi-Xin Shang, Yu-Shang Yang, Wei-Peng Hu, Yong Yuan, Ai-Fang Ji, Long-Qi Chen

MicroRNA-188 aggravates contrast-induced apoptosis by targeting SRSF7 in novel isotonic contrast-induced acute kidney injury rat models and renal tubular epithelial cells

Bowen Liu, Yunfei Chai, Wei Guo, Kaiyan Lin, Shiqun Chen, Jin Liu, Guoli Sun, Guangzhong Chen, Feier Song, Yibo He, Yan Liang, Zhaodong Guo, Li Lei, Lihao He, Liwei Liu, Ning Tan, Yong Liu, Shilong Zhong, Jiyan Chen

Prevalence of cervical spine degenerative changes in elderly population and its weak association with aging, neck pain, and osteoporosis

Xiao-Rong Wang, Timothy C. Y. Kwok, James F. Griffith, Blanche Wai Man Yu, Jason C. S. Leung, Yì Xiáng J. Wáng

Banxia Xiexin decoction, a traditional Chinese medicine, alleviates colon cancer in nude mice

Shuai Yan, Yinzi Yue, Jinbang Wang, Wenting Li, Mingming Sun, Li Zeng, Xiaopeng Wang

Ligustrazine nanoparticles nano spray’s activation on Nrf2/ARE pathway in oxidative stress injury in rats with postoperative abdominal adhesion

Shuai Yan, Yinzi Yue, Li Zeng, Chenxue Jiang, Wenlin Li, Huan Li, Yifei Qian

Apolipoprotein C1 (APOC1) as a novel diagnostic and prognostic biomarker for gastric cancer

Jie Yi, Liwen Ren, Jie Wu, Wan Li, Xiangjin Zheng, Guanhua Du, Jinhua Wang

Impact of squamous differentiation on intravesical recurrence and prognosis of patients with upper tract urothelial carcinoma

Jianpeng Yu, Gang Li, Aixiang Wang, Qiang Luo, Zihao Liu, Yuanjie Niu, Yanhui Mei

Vitamin D-binding protein (rs4588) T/T genotype is associated with anteroseptal myocardial infarction in coronary artery disease patients

Viktor Peršić, Damir Raljević, Elitza Markova-Car, Leon Cindrić, Rajko Miškulin, Marta Žuvić, Sandra Kraljević Pavelić

Neurally adjusted ventilatory assist versus pressure support ventilation in patient-ventilator interaction and clinical outcomes: a meta-analysis of clinical trials

Chongxiang Chen, Tianmeng Wen, Wei Liao

The effects of citrate dialysate in hemodialysis on polymorphonuclear elastase interaction with tissue factor and its inhibitor

Jiameng Li, Si Sun, Mei Han, Liya Wang, Ruoxi Liao, Yuqin Xiong, Yupei Li, Heng Jiang, Zheng Qin, Anil Maharjan, Mario Cozzolino, Alexander Zarbock, Baihai Su

Stereoacuity measurement using an auto-stereoscopic smartphone

Lingzhi Zhao, Huang Wu

Predictive role of intraoperative clinicopathological features of the central compartment in estimating lymph nodes metastasis status

Rong-Hao Sun, Chao Li, Yu-Qiu Zhou, Yong-Cong Cai, Chun-Yan Shui, Wei Liu, Xu Wang, Din-Fen Zeng, Jian Jiang, Jing-Qiang Zhu

The preventive effect of Chinese herbal preparation Xuebijing against hyperactive inflammation after hepato-pancreato-biliary surgery

Qifan Zhang, Jia Li, Xiaolu Liang, Haorong Xie, Hang Sun, Xinxin Lin, Jie Zhou, Xiangjun He, Bili Zhu

Lower limb arterial intervention or autologous platelet-rich gel treatment of diabetic lower extremity arterial disease patients with foot ulcers

Danlan Pu, Xiaotian Lei, Weiling Leng, Yanling Zheng, Liu Chen, Ziwen Liang, Bing Chen, Qinan Wu

Total bilirubin is negatively related to diabetes mellitus in Chinese elderly: a community study

Ping Zhong, Dongmei Sun, Danhong Wu, Xueyuan Liu

Case Report

An adult patient with congenital pulmonary airway malformation and an esophageal cyst

Hanlu Zhang, Xin He, Shangfu Zhang, Long-Qi Chen, Yun Wang

Stafne’s bone defect: a case report and review of literatures

Jun Liang, Zhaoming Deng, Han Gao

Acute coronary syndrome and diabetic keto acidosis: the chicken or the egg?

Keitiane Kaefer, Ilaria Botta, Aude Mugisha, Brahim Berdaoui, David De Bels, Rachid Attou, Patrick M. Honoré, Sebastien Redant

Letter to the Editor

Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis—reply

Julien Freitag

Editorial Commentary

Wearable cardioverter defibrillators: dead on arrival or chance of survival?

Pooja S. Jagadish, Rami N. Khouzam

Spine surgeon ownership of ambulatory surgery centers

Andre M. Samuel, Mark T. Langhans, Sravisht Iyer

The 8^th UICC/AJCC TNM edition for non-small cell lung cancer staging: getting off to a flying start?

Andrea Lancia, Elisa Merizzoli, Andrea Riccardo Filippi

Testicular germ cell tumors: the changing role of the pathologist

Andrea Ronchi, Francesca Pagliuca, Renato Franco

Apixaban or rivaroxaban in the treatment of acute venous thromboembolism?

Maja Hellfritzsch, Erik L. Grove, Kasper Adelborg

Prolonged albumin administration in patients with decompensated cirrhosis: the amount makes the difference

Manuel Tufoni, Giacomo Zaccherini, Paolo Caraceni

MGTX extension study longitudinally favors early thymectomy in non-thymomatous young-adult patients with AChR antibody-positive myasthenia gravis

Tetsuya Akaishi, Masakatsu Motomura, Masashi Aoki, Kimiaki Utsugisawa

Suggestions for radiation oncologists to overcome radiotherapy interruption in patients with nasopharyngeal cancer

Jung Ae Lee, Won Sup Yoon

Cytoreductive nephrectomy in patients with metastatic renal cell carcinoma and venous thrombus—trends and effect on overall survival

Aye A. Lwin, Grant R. Pollock, Juan Chipollini

Stereotactic ablative radiotherapy for early-stage central lung tumors: status, challenges, and future considerations

Ming Li, Cheng Zhan

Implications of the circular RNAs in localized prostate cancer

Shivansh Nigam, Nishat Manzar, Bushra Ateeq

Liquid biopsies in renal cell carcinoma with focus on epigenome analysis

Alessia Cimadamore, Matteo Santoni, Francesco Massari, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi

Advocate the implementation of video-assisted thoracoscopic surgery lobectomy program for early stage lung cancer treatment: time to transfer from why to how

Hongbin Zhang, Jens Carsten Rueckert

Levodopa treatment in Parkinson’s disease: earlier or later?

Federico Paolini Paoletti, Nicola Tambasco, Lucilla Parnetti

Vitamin D deficiency and kidney hyperfiltration: a mechanism of kidney injury?

Maya Fakhoury, Rebecca Levy, Michal L. Melamed

New functions assigned to a microRNA with genetic links to prostate cancer risk

Akira Kurozumi, Shawn E. Lupold

Whole genome sequencing in Mycobacterium tuberculosis

Andrea Spitaleri, Arash Ghodousi, Paolo Miotto, Daniela Maria Cirillo

Bleeding in patients with atrial fibrillation treated with combined antiplatelet and anticoagulant therapy: time to turn the corner

Ke Xu, Noel C. Chan

The way towards tailored treatment for metastatic renal cancer patients in the omics era: are we getting a “transcriptomic compass”?

Melissa Bersanelli, Alessio Cortellini, Sebastiano Buti

Is survival after sublobar resection vs. lobectomy made equivalent by extent of lymphadenectomy?

Kimberly J. Song, Raja M. Flores

A call for a more rigorous screening of postoperative delirium

Susanne Koch, Finn Radtke, Claudia Spies

Biomarkers in metastatic renal cell carcinoma in the era of immune checkpoint inhibitors

Abhishek Tripathi, Edwin Lin, Neeraj Agarwal

Nephrectomy in metastatic renal cell carcinoma with venous thrombus: more thrombus equals less benefit?

Mauricio Burotto, Alex Renner

The dark side of immunotherapy: challenges facing the new hope in cancer treatment

Eduard Teixidor, Joaquim Bosch-Barrera

Stereotactic body radiotherapy for oligometastatic renal cell carcinoma—are we ready to roll?

Christian C. Okoye, Ravi B. Patel, Shankar Siva, Alexander V. Louie, Simon S. Lo

Percutaneous ablation for renal masses

Devanshu Bansal, Rajeev Kumar

Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet

Jean-Pierre Quenot, Auguste Dargent, Audrey Large, Jean-Baptiste Roudaut, Pascal Andreu, Saber Barbar

Safety and delayed intervention rates of active surveillance for small renal masses in an elderly population

Brian T. Kadow, Marc C. Smaldone

Systemic therapy for metastatic renal cell carcinoma—is timing everything?

Ritesh R. Kotecha, Martin H. Voss

The importance of not only living longer but also better in the setting of advanced urothelial cancer

Haris Zahoor, Petros Grivas

The death of aspirin for primary prevention—should aspirin be changed to a prescription only medication?

Aranyak Rawal, Brandon Cave, Devarshi Ardeshna, David Hana, Uzoma N. Ibebuogu, Rami N. Khouzam

Is twice better than once?—challenges of troponin measurements for risk prediction in the general population

Henning Jansen, Dietrich Rothenbacher, Wolfgang Koenig

Diagnosis of hemoglobinopathy and β-thalassemia by 21-Tesla Fourier transform ion cyclotron resonance mass spectrometry

Jae-Seok Kim, Hyun Sik Kim

Percutaneous kidney ablation: a good option in selected cases

Samuel Weprin, Alessandro Veccia, Riccardo Autorino

Improving biochemical markers for disorders of N-glycosylation

Hudson H. Freeze

Mesenchymal stromal cells for the treatment of osteoarthritis of knee joint: context and perspective

Pawan Kumar Gupta, Charan Thej

Precision surgery for obsessive compulsive disorder—which is the proper target?

Juan Antonio Barcia, Blanca Reneses, Cristina Nombela

Managing intrinsic pro-degradatory mechanical and cellular cycles in the development of osteochondral lesions

Seok Jung Kim, Asode Ananthram Shetty, Saif Ahmed, Neha Shetty, Sang Heon Lee

VATS lobectomy for early lung cancer: long-term outcomes

Paul A. Toste, Jay M. Lee

Neoadjuvant androgen deprivation therapy through intense inhibition of the androgen target: “Midsummer Night’s Dream” or “Much Ado About Nothing”?

Alessandro Antonelli, Carlotta Palumbo, Alfredo Berruti

iMDT Corner

Cardiac MRI-guided interventional occlusion of ventricular septal rupture in a patient with cobalt alloy stent

Wei Zhong, Zhidong Liu, Weixiong Fan, Irbaz Hameed, Arash Salemi, Gianfranco Butera, Evan J. Zucker, Changjing Huang, Zhixiong Zhong

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.