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Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” More >>
Focus on “Lower extremity arthroplasty” More >>
Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” More >>

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Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge... More >>
Focused Issue on The Immature Spine More >>
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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Preface on Application of Artificial Intelligence to Radiology

Application of artificial intelligence to radiology
Timothy Deyer, Amish Doshi

Original Article on Application of Artificial Intelligence to Radiology

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI
Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer
Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging
Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric Karl Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael
Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models
John Zech, Jessica Forde, Joseph J. Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann
Random forest can accurately predict the development of end-stage renal disease in immunoglobulin a nephropathy patients
Xin Han, Xiaonan Zheng, Ying Wang, Xiaoru Sun, Yi Xiao, Yi Tang, Wei Qin

Original Article

C1Q/TNF-related protein 4 expression correlates with herpes simplex encephalitis progression
Wangshu Xu, Heng Zhou, Xiaojuan Li, Lu Wang, Xinwu Guo, Linlin Yin, Haoxiao Chang, Yuzhen Wei, Qingsong Li, Jinhai Deng, Xingang Zhou, Haifeng Yang, Xinghu Zhang, Fang Yi, Wenping Ma
miR-19b-3p promotes human pancreatic cancer Capan-2 cells proliferation by targeting phosphatase and tension homolog
Meiyi Song, Mengxue Sun, Lu Xia, Wei Chen, Changqing Yang
Perioperative sedative use is not associated with acute kidney injury after total hip or knee arthroplasty
Tak Kyu Oh, Jin-Woo Park, Hyun-Jung Shin, Hyo-Seok Na, Ah-Young Oh, Jung-Won Hwang
Salvage lymphadenectomy for isolated cervical lymph node recurrence after curative resection of thoracic esophageal squamous cell carcinoma
Zhen Wang, Shaofeng Lin, Feng Wang, Shuoyan Liu
Xuezhitong capsule, an extract of Allium macrostemon Bunge, exhibits reverse cholesterol transport and accompanies high-density lipoprotein levels to protect against hyperlipidemia in ApoE−/− mice
Xiang-Bao Meng, Ting Zhu, De-Hui Yang, Wei Liang, Gui-Bo Sun, Xiao-Bo Sun
Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds
Lan Li, Yixuan Li, Longfei Yang, Fei Yu, Kaijia Zhang, Jing Jin, Jianping Shi, Liya Zhu, Huixin Liang, Xingsong Wang, Qing Jiang
Treatment and clinical outcomes of cervical cancer during pregnancy
Jing Ma, Lan Yu, Fan Xu, Hongyan Yi, Wenfei Wei, Peng Wu, Sha Wu, Hua Li, Hong Ye, Wei Wang, Hui Xing, Liangsheng Fan
Clinical and prognostic significance of combined plasma fibrinogen concentrations and the monocyte-to-lymphocyte ratio in patients with ovarian cancer
Yuanyuan Cao, Xiuwen Ni, Yong Wang, Lejian Wang, Kai Yuan, Guofang Gan, Kunming Zhang, Zhidi Zhao, Xianming Fei
Pretransplant renal function evaluated by serum cystatin C was associated with mortality after liver transplantation: a single-center experience
Yuan Ding, Tianchun Wu, Wenyan Zhang, Sitong Zhang, Weilin Wang

Case Report

Seronegative atypical anti-glomerular basement membrane crescentic glomerulonephritis
Sreedhar Adapa, Venu Madhav Konala, Jean Hou, Srikanth Naramala, Nikhil Agrawal, Hemant Dhingra, Wilbert S. Aronow
Successful therapy for autoimmune myocarditis with pembrolizumab treatment for nasopharyngeal carcinoma
Qingqing Wang, Bijie Hu


Troubleshooting in advanced VATS procedures
Ayse Uzunel, René Horsleben Petersen


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Review Article

Original Article

Case Report

Letter to the Editor

Editorial Commentary