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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Case Report

Unusual case of spindle cell sarcoma metastases to right ventricle: a case report and a literature review
Rezarta Frakulli, Silvia Cammelli, Fabrizio Salvi, Damiano Balestrini, Antonella Baldissera, Claudio Degli Esposti, Ombretta Martelli, Massimo Abate, Anna Piaoli, Stefano Ferrari, Alessio G. Morganti, Giovanni Piero Frezza
A case of pulmonary arteriovenous malformation: role of interventional radiology in diagnosis and treatment
Pranav Sharma, Puneet Kochar, Salil Sharma, Nishant Gupta, Shuo Li, Kusum Hooda, Yogesh Kumar
Amyand’s hernia presenting as an unusual inguinal mass: a case report
Jennifer To, Paul Hanna, Ricardo Mohammed, Shauna Trinh, Franklyn Vazquez, Jamshed Zuberi, Robert Madlinger

Big-data Clinical Trial Column

Principal components analysis in clinical studies
Zhongheng Zhang, Adela Castelló

Editorial

Transcatheter mitral valve replacement: still a long way to go!
Thierry Carrel
Lung cancer prognosis: can histological patterns and morphological features have a role in the management of lung cancer patients?
Silvia Rinaldi, Rossana Berardi
Radial artery and right internal thoracic artery: jousting for the throne of coronary artery bypass grafting
Massimo Baudo, Mario Gaudino
Population health’s unanimity on lung cancer screening: far ahead of medical advice
Bruce Pyenson, Claudia I. Henschke, David F. Yankelevitz
Aortic valve repair—lessons to be learned
Johannes Petersen, Evaldas Girdauskas
Outcomes in patients undergoing transcatheter aortic valve replacement: a sex-based story of success?
René Vollenbroich
What the “man in the moon” can tell us about the future of our brains
Birgit Högl
Shared decision making in the treatment of stage I non small cell lung cancer—a choice which should equally involve both sides
Aurel Ottlakan, Jozsef Furak, Gaetano Rocco
Lung cancer screening with low dose CT and radiation harm—from prediction models to cancer incidence data
Mario Mascalchi, Lapo Sali
Bevacizumab in small cell lung cancer
Giandomenico Roviello, Navid Sobhani, Daniele Generali
An immunoregulatory role of dendritic cell-derived exosomes versus HIV-1 infection: take it easy but be warned
Dimitry A. Chistiakov, Andrey V. Grechko, Alexander N. Orekhov, Yuri V. Bobryshev
Head-stem trunnion dissociation due to corrosion in total hip arthroplasty
Michael R. Whitehouse
The surgical atrial fibrillation ablation with concomitant coronary artery bypass grafting on the testing grounds of cost and 1-year mortality
Narendra Kumar
Risk of pneumonitis with different immune checkpoint inhibitors in NSCLC
Kyrillus S. Shohdy, Omar Abdel-Rahman
The sperm stewing in its own ROS—in the plastic Petri dish
Horst-Dieter Försterling, Attila E. Pavláth, Ádám R. Mester, Antonio L. B. Pinheiro, Mario A. Trelles
Maintenance therapy in autoimmune pancreatitis: a weak light into the darkness
Luca Frulloni, Nicolò de Pretis, Antonio Amodio

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal

Commentary

Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface


Editorial



Commentary


Review Article


Original Article


Meeting Report

Report from the II melanoma translational meeting of the Spanish Melanoma Group (GEM)
Maria Gonzalez-Cao, Alfonso Berrocal, Susana Puig, Niki Karachaliou, Leticia De Matos-Arruda, Joan Seoane, David Escors, Carmen Alvarez, Jose Pedro Vaque, Aleix Prat, Claudia Wellbrock, Imanol Arozarena, Ivan Marquez-Rodas, Enrique Espinosa, Migue Angel Molina, Teresa Puertolas, Manuel Juan-Otero, Rosina Malagrida, Eloisa Jantus-Lewintre, Virtudes Soriano, Ana Arance, Jose Luis Manzano, Paul Lorigan, Thomas F. Gajewski, Rafael Rosell, On behalf of the Spanish Melanoma Group (GEM)