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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Preface

Special issue on II Translational Meeting from the Spanish Melanoma Group
Salvador Martin-Algarra, Salvador Martin-Algarra, On behalf of the Spanish Melanoma Group (GEM)

Review Article

New trends in antitumor vaccines in melanoma
Marcos Vasquez, Shirley Tenesaca, Pedro Berraondo
Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy
Miren Zuazo, Maria Gato-Cañas, Noelia Llorente, María Ibañez-Vea, Hugo Arasanz, Grazyna Kochan, David Escors
Dendritic cell therapy in melanoma
Carmen Alvarez-Dominguez, Ricardo Calderón-Gonzalez, Hector Terán-Navarro, David Salcines-Cuevas, Almudena Garcia-Castaño, Javier Freire, Javier Gomez-Roman, Fernando Rivera
Overcoming resistance to BRAF inhibitors
Imanol Arozarena, Claudia Wellbrock
The combination of checkpoint immunotherapy and targeted therapy in cancer
Niki Karachaliou, Maria Gonzalez Cao, Aaron Sosa, Jordi Berenguer, Jillian Wilhelmina Paulina Bracht, Masaoki Ito, Rafael Rosell
Predictive factors of response to immunotherapy—a review from the Spanish Melanoma Group (GEM)
Enrique Espinosa, Ivan Márquez-Rodas, Ainara Soria, Alfonso Berrocal, Jose Luis Manzano, Maria Gonzalez-Cao, Salvador Martin Algarra, On behalf of the Spanish Melanoma Group (GEM)

Meeting Report

Report from the II melanoma translational meeting of the Spanish Melanoma Group (GEM)
Maria Gonzalez-Cao, Alfonso Berrocal, Susana Puig, Niki Karachaliou, Leticia De Matos-Arruda, Joan Seoane, David Escors, Carmen Alvarez, Jose Pedro Vaque, Aleix Prat, Claudia Wellbrock, Imanol Arozarena, Ivan Marquez-Rodas, Enrique Espinosa, Migue Angel Molina, Teresa Puertolas, Manuel Juan-Otero, Rosina Malagrida, Eloisa Jantus-Lewintre, Virtudes Soriano, Ana Arance, Jose Luis Manzano, Paul Lorigan, Thomas F. Gajewski, Rafael Rosell, On behalf of the Spanish Melanoma Group (GEM)
Highlights of the season 2016–2017 by the Spanish Melanoma Group (GEM)
Ainara Soria, Jose Luis Manzano, Alfonso Berrocal, Enrique Espinosa, Ivan Marquez-Rodas, Maria Gonzalez-Cao, Salvador Martin-Algarra, On behalf of the Spanish Melanoma Group (GEM)
Infomelanoma 2020: an online digital application designed to assist health professionals for melanoma treatment
Maria González-Cao, Mar Carrasco-Calvo, Ainara Soria, Alfonso Berrocal, Ana Arance, Susana Puig, Laura Alós, Santiago Viteri, Pablo Cerezuela, Salvador Martín-Algarra

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal

Commentary

Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Editorial


Perspective


Commentary


Review Article


Original Article


Case Report



Letter to the Editor


Big-data Clinical Trial Column



Technical Note