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Focus on “4th Hong Kong International Oncology Symposium 2017” edited by Dr. William C. S. Cho and Dr. Joseph S. K. Au

With the advent of technology, we are now at a turning point in the history of cancer management. The aim of the Hong Kong International Oncology Symposium is to bring those innovations likely to have an important impact on cancer management to the professional community. Our theme for this year’s symposium is newer immunotherapeutic approaches, functional genomics and precision medicine, advances in precision radiotherapy, including proton therapy and updates on the management of lung and urogenital cancers.

Focus on “Quality in Gastrointestinal Endoscopy” edited by Dr. Konstantinos Triantafyllou, Dr. Spyridon Michopoulos and Dr. Cesare Hassan

In this special issue, invited authors highlighted specific issues regarding quality assessment and improvement of endoscopic service provision which are not usually covered in the available guidelines. We believe that readers will enjoy this focused issue that aims to provide further simplified guidance for the implementation and monitor of performance measures at their practice, so that patients can get the highest possible care.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Focus on “Molecular Medicine” edited by Dr. Christina Piperi and Dr. Athanasios G. Papavassiliou

Welcome to this thematic issue of Annals of Translational Medicine on the recent advances of the ever-expanding field of molecular medicine. The present volume attempts to cover current genetic, molecular, or cellular aspects of main subject areas including microbiology, haematology, biomechanics, oncology, endocrinology, pharmacology, cardiology and hepatology. It is primarily focused on recent developments on molecular biomarkers and current technologies that elucidate disease pathogenesis and may lead to the design of specific tools for diagnosis, treatment, or disease prevention

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Articles from these leading researchers, taken together, effectively paint the picture on a wide canvas and shine a spotlight on critical issues facing the translational oncology community. These leading experts provide a state-of-the-art assessment of timely questions spanning cancer research, from bedside to clinic (and back), including but not limited to accurate molecular assessment of genomic profiles, predictive and prognostic biomarkers, determination of appropriate treatments based on economic profiles, and also the financial toxicity stemming from the recent new wave of effective but expensive cancer-targeting therapies in lung cancer, breast cancer, colorectal cancer, and prostate cancer.

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Lung cancer remains the leading cause of cancer related death worldwide, with approximately 1.6 million deaths recorded in 2015. Non-small cell lung cancer (NSCLC) accounts for approximately 80–85% of cases. Despite broad advances in diagnostics and therapy, the 5-year overall survival for patients with advanced NSCLC has not significantly changed over the past few years. Following the decoding of human cancer genome and the advent of therapies targeting driver mutations, the choice of systemic therapy changed from “one size fits all” approach to a more precise selection of biologic therapies targeting distinct genetic profiles, the so-called “precision” medicine.

Focus on “Art of Minimally Invasive Spine Surgery” edited by Dr. Roger Härtl and Dr. Ai-Min Wu

This special issue reports the newest MISS techniques in the treatment of a wide spectrum of spinal disorders. This timely issue will be extremely useful to spine surgeons, orthopedic surgeons, neurological surgeons, and young scientists who are interested in MISS. As MISS is still in its evolution, we also hope that this issue can bring some inspiration to readers to contribute to its progress.

Join us at AIMed Europe, London 11-13 September 2018 + Datathon sponsored by Google Cloud

Find out more about the role AI has to play in our future at the AIMed Europe conference in London on 11-13 September. This is the largest and most comprehensive multi-disciplinary AI in healthcare and medical conference in Europe.

AIMed Europe is an engaging, strategic-level platform for clinicians, physicians, CIOs and CMIOs, Data and Computer Scientists, Investors and Entrepreneurs.

The conference will take place over 5 days and include for the first time, a Datathon - Sponsored by Google Cloud

www.aimed.events/europe

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

Good news continues to roll in! Announced by Clarivate Analytics, former Thomson Reuters Intellectual Property and Science Business, Annals of Translational Medicine (known as ATM), under AME Publishing Company, is officially indexed in Science Citation Index Expanded (SCIE) on 02 March, 2018

2017 Annual Report of ATM

We are glad to present the 2017 Annual Report of ATM here. In 2017, ATM progressed fast and smoothly under the join-efforts of experts worldwide. The total citation number has significantly increased from 1294 in January to 3314 in December. The journal was also exhibited in some international meetings, to attract wider attention and exposure. More information is shown in the Annual Report.
We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy, healthy and prosperous 2018!

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

Sleep apnea is associated with worse outcomes following various kinds of surgeries. There is a paucity of data on the association of sleep apnea with clinical outcomes after transcatheter aortic valve replacement (TAVR).

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

Allenbach and colleagues have recently reported for the first time the results of an intriguing study of the histopathologic, immunopathologic and gene expression differences in muscle biopsy tissue from adult dermatomyositis (DM) patients who do and do not have circulating MDA5 autoantibodies (anti-MDA5). Anti-MDA5 were originally identified in a clinically-defined subset of DM patients whose disease was expressed predominately in the skin for unusually long periods of time without accompanying muscle weakness [i.e., “clinically-amyopathic DM” (CADM)] and were at risk for acute, rapidly-progressive form of interstitial lung disease (ILD)...

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Vol 6, No 17 (September, 2018)

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Focused Issues more

Focus on “4th Hong Kong International Oncology Symposium 2017” More >>

Focus on “Quality in Gastrointestinal Endoscopy” More >>

Focus on “Molecular Medicine” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Preface

Rare diseases: the paradox of an emerging challenge

Elisa Danese, Giuseppe Lippi

PDF Full Text

Original Article

The burden of cardiac arrhythmias in sarcoidosis: a population-based inpatient analysis

Rupak Desai, Kiranmayi Kakumani, Hee Kong Fong, Bhrugesh Shah, Daniyal Zahid, Dipen Zalavadia, Rajkumar Doshi, Hemant Goyal

PDF Full Text

Review Article

Rare congenital bleeding disorders

Massimo Franchini, Giuseppe Marano, Simonetta Pupella, Stefania Vaglio, Francesca Masiello, Eva Veropalumbo, Vanessa Piccinini, Ilaria Pati, Liviana Catalano, Giancarlo Maria Liumbruno

PDF Full Text

Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?

Nicholas G. Kounis, Gianfranco Cervellin, Ioanna Koniari, Laura Bonfanti, Periklis Dousdampanis, Nikolaos Charokopos, Stelios F. Assimakopoulos, Stavros K. Kakkos, Ioannis G. Ntouvas, George D. Soufras, Ioannis Tsolakis

PDF Full Text

Current and future roles of mucins in cholangiocarcinoma—recent evidences for a possible interplay with bile acids

Elisa Danese, Andrea Ruzzenente, Martina Montagnana, Patricia Marie-Jeanne Lievens

PDF Full Text

Molecular basis of cystic fibrosis: from bench to bedside

Maria Cristina Dechecchi, Anna Tamanini, Giulio Cabrini

PDF Full Text

Insulin autoimmune syndrome: from diagnosis to clinical management

Simona Censi, Caterina Mian, Corrado Betterle

PDF Full Text

Sclerosing mesenteritis: a comprehensive clinical review

Michael S. Green, Rajiv Chhabra, Hemant Goyal

PDF Full Text

Diagnostic insights into chronic-inflammatory demyelinating polyneuropathies

Johannes J. Roggenbuck, Joseph Boucraut, Emilien Delmont, Karsten Conrad, Dirk Roggenbuck

PDF Full Text

Metabolomics: a challenge for detecting and monitoring inborn errors of metabolism

Michele Mussap, Marco Zaffanello, Vassilios Fanos

PDF Full Text

Old and new insights into the diagnosis of hereditary spherocytosis

Olga Ciepiela

PDF Full Text

Diagnosis of neurodegenerative dementia: where do we stand, now?

Giulia M. Sancesario, Sergio Bernardini

PDF Full Text

Biochemical markers of acute intestinal ischemia: possibilities and limitations

Martina Montagnana, Elisa Danese, Giuseppe Lippi

PDF Full Text

Rare thrombophilic conditions

Gian Luca Salvagno, Chiara Pavan, Giuseppe Lippi

PDF Full Text

Sleep-disordered breathing in paediatric setting: existing and upcoming of the genetic disorders

Marco Zaffanello, Franco Antoniazzi, Laura Tenero, Luana Nosetti, Michele Piazza, Giorgio Piacentini

PDF Full Text

e-thrombosis: epidemiology, physiopathology and rationale for preventing computer-related thrombosis

Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro

PDF Full Text

Rare forms of von Willebrand disease

Emmanuel J. Favaloro

PDF Full Text

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Heart-lung interactions in the ICU: physiology, evaluation and clinical applications

Antoine Vieillard-Baron

Editorial

Hyperphosphatemia: a novel risk factor for mortality in chronic kidney disease

Mario Cozzolino, Paola Ciceri, Andrea Galassi

Heart-lung interactions, a long story with many pioneers

Didier Payen

Recombinant poliovirus for cancer immunotherapy

Millena Prata Jammal, Márcia Antoniazi Michelin, Rosekeila Simões Nomelini, Eddie Fernando Candido Murta

Does the change of hypertension guidelines actually affect our reality?

Marijana Tadic, Cesare Cuspidi

Relationship between microaspiration of gastric contents and ventilator-associated pneumonia

Anahita Rouzé, Emmanuelle Jaillette, Saad Nseir

Where does polycystic ovary syndrome come from?

Roy Homburg

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The link between antibiotic exposure and kidney stone disease

Kymora Scotland, Dirk Lange

Cost-effectiveness of model-based eligibility for lung cancer screening in the routine clinical practice

Salvatore Intagliata, Elisa Roca, Deborah Cosentini, Alfredo Berruti

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Early osteoarthritis of the knee: from conservative to surgical management

Pier Francesco Indelli, Michele Giuntoli

Is the mechanical power the final word on ventilator-induced lung injury?—we are not sure

Francesco Vasques, Eleonora Duscio, Iacopo Pasticci, Federica Romitti, rancesco Vassalli, Michael Quintel, Luciano Gattinoni

“A rose by any other name”: does defining extreme phenotypes add to the management of multiple sclerosis?

Evan A. Jolliffe, Brian G. Weinshenker

Trends in ACL reconstruction: an “individualized approach”

Philippe Landreau

Translational animal models for endometriosis research: a long and windy road

Antonio Simone Laganà, Simone Garzon, Massimo Franchi, Jvan Casarin, Giuseppe Gullo, Fabio Ghezzi

Calcium and/or vitamin D supplementation: could they affect your risks of colorectal cancer development or progression?

Lynnette R. Ferguson

Search for a reliable biomarker of acute kidney injury: to the heart of the problem

Luca Di Lullo, Biagio Raffaele Di Iorio, Claudio Ronco, Antonio Bellasi

The new basal insulin analog glargine U-300 enables flexible injection schedule

Uru Nezu Osada, Yasuo Terauchi

HLA-B*58:01 is not the only risk factor associated with allopurinol-induced severe cutaneous adverse drug reactions

Margarida Gonçalo

Molecular imaging in large vessel vasculitis has come to stay

Isabel Martínez-Rodríguez, Miguel A. González-Gay, Diana Prieto-Peña, Ignacio Banzo

TBX20 and the PROK2-PROKR1 pathway—new kid on the block in angiogenesis research

Michael Lichtenauer, Christian Jung

Tumor inactivation of E-cadherin: a new tool for breast cancer treatment?

Giovanni Corso, Bernardo Bonanni, Paolo Veronesi

Durability of mitral valve repair for degenerative mitral regurgitation: is it gold all that glitters?

Antonio M. Calafiore, Antonio Totaro, Massimiliano Foschi, Michele Di Mauro

Anticoagulation after mechanical aortic valve implantation: is it time to act after PROACT?

Mevlüt Çelik, Andras P. Durko, Stuart J. Head

Self-condensation culture for vascularized organoid

Shoichiro Sumi

The benefits of youth sports participation should outweigh the risks

Carola F. van Eck, Freddie H. Fu

Is B-type natriuretic peptide (BNP) similarly associated with mortality in patients with and without heart failure?

Norihide Fukushima

Extracorporeal membrane oxygenation in acute respiratory distress syndrome: why is the EOLIA trial important?

Nicolas Persico, Christophe Guervilly, Antoine Roch, Laurent Papazian

Osteochondral lesions of the talus: are we ready for metal?

Riccardo D’Ambrosi, Federico Giuseppe Usuelli

Evaluation of kinematic changes of intervertebral discs and the space available for the cord

Federico Canavese, Yann Philippe Charles, Alain Dimeglio

Adult mesenchymal stem cells for the treatment in patients with rotator cuff disease: present and future direction

Dong Rak Kwon, Gi-Young Park

Local modalities for inoperable hepatocellular carcinoma: radiofrequency ablation versus stereotactic body radiotherapy

Sun Hyun Bae, Hee Chul Park

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Genetics in systemic lupus erythematosus: entering the borough of cardiovascular risk

Giuseppe A. Ramirez

LXRs are finally being adequately targeted in atherosclerosis

Julio Buñay, Silvère Baron, Jean-Marc A. Lobaccaro

Immunoscore—has it scored for colon cancer precision medicine?

Robert N. Jorissen, Anuratha Sakthianandeswaren, Oliver M. Sieber

Surrogate study endpoints in the era of cancer immunotherapy

Tsuyoshi Hamada, Keisuke Kosumi, Yousuke Nakai, Kazuhiko Koike

The hemodynamic effects of norepinephrine: far more than an increase in blood pressure!

Pierre Foulon, Daniel De Backer

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Perspective

Should we titrate mechanical ventilation based on driving pressure?—yes

Carmen Silvia Valente Barbas, Roberta Fittipaldi Palazzo

Should we titrate peep based on end-expiratory transpulmonary pressure?—yes

Elias Baedorf Kassis, Stephen H. Loring, Daniel Talmor

Can we estimate transpulmonary pressure without an esophageal balloon?—yes

Ola Stenqvist, Per Persson, Stefan Lundin

Should we titrate positive end-expiratory pressure based on an end-expiratory transpulmonary pressure?

John J. Marini

Review Article

Physiology-guided management of hemodynamics in acute respiratory distress syndrome

Gustavo A. Cortes-Puentes, Richard A. Oeckler, John J. Marini

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Non-invasive ventilation in cardiogenic pulmonary edema

Giuseppe Bello, Paolo De Santis, Massimo Antonelli

Prediction of fluid responsiveness in ventilated patients

Mathieu Jozwiak, Xavier Monnet, Jean-Louis Teboul

Value of measuring esophageal pressure to evaluate heart-lung interactions—applications for invasive hemodynamic monitoring

Xavier Repessé, Antoine Vieillard-Baron, Guillaume Geri

Interpretation of the transpulmonary pressure in the critically ill patient

Michele Umbrello, Davide Chiumello

Determinants of systemic venous return and the impact of positive pressure ventilation

David Berger, Jukka Takala

Effects of patient positioning on respiratory mechanics in mechanically ventilated ICU patients

Mehdi Mezidi, Claude Guérin

Assessing breathing effort in mechanical ventilation: physiology and clinical implications

Heder de Vries, Annemijn Jonkman, Zhong-Hua Shi, Angélique Spoelstra-de Man, Leo Heunks

Mechanical ventilation management during cardiothoracic surgery: an open challenge

Elena Bignami, Francesco Saglietti, Antonio Di Lullo

Cardiovascular failure and weaning

Philippe Vignon

The basics of respiratory mechanics: ventilator-derived parameters

Pedro Leme Silva, Patricia R. M. Rocco

Heart-Lung interaction in spontaneous breathing subjects: the basics

Sheldon Magder

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Management and weaning from mechanical ventilation in neurologic patients

Raphaël Cinotti, Marwan Bouras, Antoine Roquilly, Karim Asehnoune

Evaluation of cardiac function using heart-lung interactions

Victoria A. Bennett, Hollmann D. Aya, Maurizio Cecconi

Respiratory mechanics in patients with acute respiratory distress syndrome

Vincenzo Russotto, Giacomo Bellani, Giuseppe Foti

Is intra-abdominal hypertension a risk factor for ventilatorassociated pneumonia?

Eleni Papakrivou, Eustratios Manoulakas, Epaminondas Zakynthinos, Demosthenes Makris

Technical aspects of bedside respiratory monitoring of transpulmonary pressure

Francesco Mojoli, Francesca Torriglia, Anita Orlando, Isabella Bianchi, Eric Arisi, Marco Pozzi

Original Article

Boiling and roasting treatment affecting the peanut allergenicity

Tong Zhang, Yunfeng Shi, Yanqing Zhao, Guowei Tang, Bing Niu, Qin Chen

Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer’s disease: a multicenter pilot study

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