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Reading Companion: Blooming Flowers -A call for paper

Parent's Comments: Huilongwo was built in the Qing Dynasty. It is now a historic and cultural district in Xuzhou, in the center of the city. The old building in the painting is a corner of Huilongwo. Generally, children’s life experience lacks deeper nuances to understand the historical implications of architecture, in this painting, you can still see traces of tranquillity and vicissitudes. The usage of colors in this gives the old building vitality.

Focus on “Novel Aspects in Ventilator-associated Pneumonia” edited by Dr. Saad Nseir and Dr. Ignacio Martin-Loeches

Ventilator-associated pneumonia (VAP) remains an important clinical problem, being associated with significant morbidity and mortality. In this special issue of Annals of Translational Medicine, novel aspects regarding definition, diagnosis, epidemiology, and treatment of VAP are discussed by experts in this field.

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care” edited by Prof. Keith C. Ferdinand

This special issue of the ATM provides perspectives on cardiovascular disease (CVD) not only in the United States (US), but also worldwide. We present a global, comprehensive view of innovative research, reviews, editorials and perspectives from basic science at the bench level to clinic interventions and public health considerations. While this edition of ATM builds on much of the research and clinical care conducted at Tulane University School of Medicine in New Orleans, Louisiana, USA, it also highlights provocative insights from other authors from the USA, along with articles from basic science researchers, clinicians and public health specialists from Africa, Europe, Asia and South America.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Focus on “Molecular Medicine” edited by Dr. Christina Piperi and Dr. Athanasios G. Papavassiliou

Welcome to this thematic issue of Annals of Translational Medicine on the recent advances of the ever-expanding field of molecular medicine. The present volume attempts to cover current genetic, molecular, or cellular aspects of main subject areas including microbiology, haematology, biomechanics, oncology, endocrinology, pharmacology, cardiology and hepatology. It is primarily focused on recent developments on molecular biomarkers and current technologies that elucidate disease pathogenesis and may lead to the design of specific tools for diagnosis, treatment, or disease prevention

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Articles from these leading researchers, taken together, effectively paint the picture on a wide canvas and shine a spotlight on critical issues facing the translational oncology community. These leading experts provide a state-of-the-art assessment of timely questions spanning cancer research, from bedside to clinic (and back), including but not limited to accurate molecular assessment of genomic profiles, predictive and prognostic biomarkers, determination of appropriate treatments based on economic profiles, and also the financial toxicity stemming from the recent new wave of effective but expensive cancer-targeting therapies in lung cancer, breast cancer, colorectal cancer, and prostate cancer.

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Lung cancer remains the leading cause of cancer related death worldwide, with approximately 1.6 million deaths recorded in 2015. Non-small cell lung cancer (NSCLC) accounts for approximately 80–85% of cases. Despite broad advances in diagnostics and therapy, the 5-year overall survival for patients with advanced NSCLC has not significantly changed over the past few years. Following the decoding of human cancer genome and the advent of therapies targeting driver mutations, the choice of systemic therapy changed from “one size fits all” approach to a more precise selection of biologic therapies targeting distinct genetic profiles, the so-called “precision” medicine.

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

Good news continues to roll in! Announced by Clarivate Analytics, former Thomson Reuters Intellectual Property and Science Business, Annals of Translational Medicine (known as ATM), under AME Publishing Company, is officially indexed in Science Citation Index Expanded (SCIE) on 02 March, 2018

2017 Annual Report of ATM

We are glad to present the 2017 Annual Report of ATM here. In 2017, ATM progressed fast and smoothly under the join-efforts of experts worldwide. The total citation number has significantly increased from 1294 in January to 3314 in December. The journal was also exhibited in some international meetings, to attract wider attention and exposure. More information is shown in the Annual Report.
We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy, healthy and prosperous 2018!

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

Sleep apnea is associated with worse outcomes following various kinds of surgeries. There is a paucity of data on the association of sleep apnea with clinical outcomes after transcatheter aortic valve replacement (TAVR).

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

Allenbach and colleagues have recently reported for the first time the results of an intriguing study of the histopathologic, immunopathologic and gene expression differences in muscle biopsy tissue from adult dermatomyositis (DM) patients who do and do not have circulating MDA5 autoantibodies (anti-MDA5). Anti-MDA5 were originally identified in a clinically-defined subset of DM patients whose disease was expressed predominately in the skin for unusually long periods of time without accompanying muscle weakness [i.e., “clinically-amyopathic DM” (CADM)] and were at risk for acute, rapidly-progressive form of interstitial lung disease (ILD)...

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Vol 7, No 1 (January, 2019)

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Focused Issues more

Focus on “Novel Aspects in Ventilator-associated Pneumonia” More >>

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to... More >>

Focus on “Cardiopulmonary Interactions” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Diagnostic performance of C-reactive protein for parapneumonic pleural effusion: a meta-analysis

Dajiang Li, Yongchun Shen, Jiangyue Qin, Chun Wan, Ni Zeng, Lei Chen, Yue Dong

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Histone deacetylase 6 selective inhibitor ACY1215 inhibits cell proliferation and enhances the chemotherapeutic effect of 5-fluorouracil in HCT116 cells

Yuyong Tan, Shilan Zhang, Hongyi Zhu, Yi Chu, Hejun Zhou, Deliang Liu, Jirong Huo

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Can the echocardiographic LV mass equation reliably demonstrate stable LV mass following acute change in LV load?

Kavisha Patel, Nidhish Tiwari, Wilbert S. Aronow, Daniel Spevack

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Who will benefit from thymectomy for myasthenia gravis? Is there any role for this procedure in elderly patients?

Ryo Otsuka, Kazuhiro Ueda, Toshiki Tanaka, Junichi Murakami, Masataro Hayashi, Kimikazu Hamano

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The profile of patients receiving public and private surgical services in Greece during the economic crisis: a comparative study

Dimitrios Schizas, Adamantios Michalinos, Prodromos Kanavidis, Georgios Karaolanis, Irene Lidoriki, Athanasios D. Sioulas, Dimitrios Moris

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Behavioral defects induced by chronic social defeat stress are protected by Momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT neuroinflammatory pathway

Zhifang Deng, Cheng Yuan, Jian Yang, Yan Peng, Wei Wang, Yan Wang, Wenqi Gao

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Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

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Evaluation of clinical risk factors for predicting insidious right central and posterior right recurrent laryngeal nerve lymph node metastasis in papillary thyroid microcarcinoma patients (cN0): experience of a single center

Fuqiang Li, Yijun Wu, Liang Chen, Liang Hu, Xiaosun Liu

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Muscle weakness in a S. pneumoniae sepsis mouse model

Esther Witteveen, Luuk Wieske, Emmy Manders, Camiel Verhamme, Coen A. C. Ottenheijm, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn

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Review Article

Interpretation and clinical practice of regulation for prevention and control of healthcare associated infection in outpatient and emergency department in healthcare facilities

Wen-Sen Chen, Fu Qiao, Yue Yang, Xiao-Dong Gao, Zhan-Jie Li, Yong-Xiang Zhang, Wei-Hong Zhang, Qiang Fu, Yun Liu

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Case Report

Diaphragmatic hernia with isolated shoulder pain evoked by surfeit

Junghee Lee, Seung Hyuk Nam, Si-Wook Kim, Jong-Myeon Hong, Dohun Kim

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A tension tracheal diverticulum: recurrence after interventional sclerotherapy followed by transcervical resection

Hui-Jiang Gao, Lei Gong, Zhi-Hui Jiang, Yu-Cheng Wei, Kai Ma

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Hyaluronic acid-induced diffuse alveolar hemorrhage: unknown complication induced by a well-known injectable agent

Seoung Woo Han, Myung Jae Park, Seung Hyeun Lee

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Third-generation tyrosine kinase inhibitor in the treatment of epidermal growth factor receptor mutated squamous cell lung cancer: a tailored therapy approach

Francesco Cortiula, Giovanna De Maglio, Maria Giulia Cangi, Lorenzo Gerratana, Camilla Lisanti, Salvatore Bonura, Gianpiero Fasola, Alessandro Follador

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Column in Laboratory Medicine

Is digital epidemiology reliable?—insight from updated cancer statistics

Giuseppe Lippi, Gianfranco Cervellin

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Big-data Clinical Trial Column

Balance diagnostics after propensity score matching

Zhongheng Zhang, Hwa Jung Kim, Guillaume Lonjon, Yibing Zhu, written on behalf of AME Big-Data Clinical Trial Collaborative Group

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Meet the Professor

Prof. Bruce R. Blazar: status, challenge, and prospect of the clinical applications in graft-versus-host disease

Luna Young

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Prof. Bin Zhang: no pains, no gains

Crystal M. Yan

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Editorial

Vascular injuries during VATS lobectomies: keep calm, compress and have a plan

Luca Bertolaccini, Francesca Calabrese, Jury Brandolini, Piergiorgio Solli

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Bleeding control during VATS major lung resection without conversion: safe and feasible?

Fabrizio Minervini, Peter Bruno Kestenholz, Luca Bertolaccini, Benedetta Bedetti, Davide Patrini, Enrico Cassina, Marco Scarci

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What the future holds for the primary surgical repair as treatment of a massive pressure ulcer?

Aabid Sanaullah, Mohamed H. Ahmed

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Trochanteric pressure ulcers: preoperative management and reconstructive considerations

Giulia Daneshgaran, Michael N. Cooper, Jaeyon Park, Christopher G. Pimentel, Alex K. Wong

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How high is your conversion rate?—as high as necessary

Ralitsa Baranowski, David A. Waller

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Is the video-assisted pulmonary segmentectomy the preferred approach to the early stage non-small cell lung cancer?

Alessandro Pardolesi, Luca Bertolaccini, Ugo Pastorino

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Prevention is better than cure!

Mariagrazia Lorusso, Angela De Palma, Giulia De Iaco, Giuseppe Marulli

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Refining thoracoscopic left S3 segmentectomy by a unidirectional approach

Wolfgang Jungraithmayr

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Editorial for focused issue “Wilson Disease: From Genetics to Management of Disease”

Ralf Weiskirchen, Wolfgang Stremmel

Recent update of image diagnostic and therapeutic modalities in thoracic surgery

Jin-Shing Chen, Mong-Wei Lin, Ke-Cheng Chen

Editorial

Hyperphosphatemia: a novel risk factor for mortality in chronic kidney disease

Mario Cozzolino, Paola Ciceri, Andrea Galassi

High flow oxygen therapy and the work of breathing assessed by thickening fraction of the diaphragm (TFdi): just a side of the moon in cystic fibrosis patients?

Nadia Corcione, Paolo Buonpensiero, Antonio M. Esquinas

Improving the diagnosis of renal masses: can we approach the histological diagnosis to the image?

José Miguel Giménez-Bachs, Antonio S. Salinas-Sánchez

Comprehensive genomic analysis of circulating tumor DNA for patients with advanced non-small cell lung cancer

Delphine Lissa, Ana I. Robles

Mesenchymal stem cell therapy for neonatal intraventricular hemorrhage: a long way to go?

Shinya Abe, Kazumichi Fujioka

New genetic characteristics of latent autoimmune diabetes in adults (LADA)

Yan Chen, Gang Chen

Modern human lifestyle prejudices epigenetic changes to cuddle diseases

Narasimman Gurusamy, Johnson Rajasingh

GABA strikes down again in epilepsy

Milena Guazzi, Pasquale Striano

Extracellular vesicles in hepatocellular cancer and cholangiocarcinoma

Feihu Xie, Shi Feng, Huayu Yang, Yilei Mao

Is the onset of adverse effects of immunotherapy always bad news for the patients…?—certainly not!

Paul Hofman

Long-acting glucagon-like peptide-1 receptor agonist—status December 2018

Jens Juul Holst

Pro-tumoral role of gut bacteria: sabotaging immune cell recruitment

Giandomenica Iezzi, Eleonora Cremonesi, Pietro E. Majno

Minimally invasive segmentectomy for early stage lung cancer gains momentum

Syed S. Razi, Dao Nguyen, Nestor Villamizar

Central nervous system activity of first-line osimertinib in epidermal growth factor receptor-mutant advanced non-small cell lung cancer

Chong-Kin Liam

Fluorescence-guided surgery in cancer treatment: current status and future perspectives

Yongchang Zheng, Huayu Yang, Henan Wang, Kai Kang, Wenkai Zhang, Gang Ma, Shunda Du

Meningeal lymphatics in aging and Alzheimer’s disease

Russell J. Jaffe, Rajnish S. Dave, Siddappa N. Byrareddy

Percutaneous coronary intervention in left main disease: 10-year follow-up

Akihiro Kobayashi, Naoki Misumida

Is active surveillance an option for metachronous metastatic renal cell carcinoma?

Vincenzo Ficarra, Alessandra Mosca, Marta Rossanese, Enrica Subba, Gianluca Giannarini

Pathophysiology of pain in patients with peritoneal endometriosis

Simone Ferrero, Valerio Gaetano Vellone, Fabio Barra

Perspective

Perspectives of value-based policy making in child health care in Japan

Ruoyan Gai Tobe, Hiroshi Fuji, Hirohito Metoki, Akira Ehara, Tsuguhiko Kato, Hakuyo Ebara, Toshihiko Nishida, Gen Kobashi, Rintaro Mori

Can presepsin be used for screening invasive fungal infections?

Giuseppe Lippi, Gianfranco Cervellin

Review Article

Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma mass spectrometry

Sabine Weiskirchen, Philipp Kim, Ralf Weiskirchen

Routine use of commercial antibiotic-loaded bone cement in primary total joint arthroplasty: a critical analysis of the current evidence

Assem A. Sultan, Linsen T. Samuel, Erica Umpierrez, Andrew Swiergosz, Jacob Rabin, Bilal Mahmood, Michael A. Mont

Astym^® therapy: A systematic review

Morad Chughtai, Jared M. Newman, Assem A. Sultan, Linsen T. Samuel, Jacob Rabin, Anton Khlopas, Anil Bhave, Michael A. Mont

Hybrid operating room for the intraoperative CT-guided localization of pulmonary nodules

Hsin-Yueh Fang, Ko-Wei Chang, Yin-Kai Chao

Latest technology in minimally invasive thoracic surgery

Ivan Chi Hin Siu, Zheng Li, Calvin S. H. Ng

Wilson disease—treatment perspectives

Tomasz Litwin, Karolina Dzieżyc, Anna Członkowska

Clinical practice guidelines in Wilson disease

Chiara Saroli Palumbo, Michael L. Schilsky

Latest update about virtual-assisted lung mapping in thoracic surgery

Kentaro Kitano, Masaaki Sato

Prediction of pleural invasion using different imaging tools in non-small cell lung cancer

Jhih-Hao Bai, Min-Shu Hsieh, Hsien-Chi Liao, Mong-Wei Lin, Jin-Shing Chen

Role of bronchoalveolar lavage in the management of immunocompromised patients with pulmonary infiltrates

Randall Choo, Devanand Anantham

Original Article

Long-term effects of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: systematic review and single-arm meta-analyses

Zongshi Qin, Jiani Wu, Chang Xu, Xiaopu Sang, Xiao Li, Guangrui Huang, Zhishun Liu

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI

Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models

John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann

Not all primary total hip arthroplasties are equal—so is there a difference in reimbursement?

Nipun Sodhi, Sarah E. Dalton, Luke J. Garbarino, Peter A. Gold, Nicolas S. Piuzzi, Jared M. Newman, Anton Khlopas, Assem A. Sultan, Morad Chughtai, Michael A. Mont

Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging

Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric K. Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael

Patient satisfaction and outcomes of static progressive stretch bracing: a 10-year prospective analysis

Nipun Sodhi, Benjamin Yao, Hiba K. Anis, Anton Khlopas, Assem A. Sultan, Jared M. Newman, Michael A. Mont

A real-world study on adverse drug reactions to Xuebijing injection: hospital intensive monitoring based on 93 hospitals (31,913 cases)

Rui Zheng, Hui Wang, Zhi Liu, Xiaohui Wang, Jing Li, Xiang Lei, Yilin Fan, Si Liu, Zhiqiao Feng, Hongcai Shang

Single-stage hybrid localization: a combination of bronchoscopic lung mapping followed by post-mapping computed tomographic reconstruction and additional transthoracic needle localization in a cone beam computed tomography room

Shun-Mao Yang, Wei-Chun Ko, Ling-Hsuan Meng, Li-Wei Chen, Kun-Hsien Lin, Yueh-Lun Liu, Shao-En Sun, Huan-Jang Ko

Non-intubated thoracoscopic surgery for lung cancer in patients with impaired pulmonary function

Man-Ling Wang, Ming-Hui Hung, Hsao-Hsun Hsu, Kuang-Cheng Chan, Ya-Jung Cheng, Jin-Shing Chen

The role of prehabilitation with a telerehabilitation system prior to total knee arthroplasty

Morad Chughtai, Neil V. Shah, Assem A. Sultan, Maximillian Solow, John V. Tiberi, Nima Mehran, Trevor North, Joseph T. Moskal, Jared M. Newman, Linsen T. Samuel, Anil Bhave, Michael A. Mont

Using meta-regression approach to explore the dose-response association between acupuncture sessions and acupuncture effects on chronic prostatitis/chronic pelvic pain syndrome

Zongshi Qin, Jiani Wu, Chang Xu, Zhishun Liu

Random forest can accurately predict the development of end-stage renal disease in immunoglobulin a nephropathy patients

Xin Han, Xiaonan Zheng, Ying Wang, Xiaoru Sun, Yi Xiao, Yi Tang, Wei Qin

Validity and reliability of patient section of evidence-based medical records about doctor-patient building through integrated therapy of traditional Chinese and Western medicine (DPEBMR-P) in patients with gastrointestinal diseases

Shuo Feng, Lingxiao Chen, Guihua Tian, Jing Hu, Yang Ding, Zhengguang Du, Hongkai Zhang, Bo Li, Yang Li

Quantitative feature analysis of CT images of transbronchial dye markings mimicking true pulmonary ground-glass opacity lesions

Bo-Wei Chen, Li-Wei Chen, Shun-Mao Yang, Ching-Kai Lin, Huan-Jang Ko, Chung-Ming Chen

Efficacy and safety of the Fu-Zheng-Qu-Zhuo method on retarding the progress of chronic kidney disease (stage 3–4): a systematic review and meta-analysis

Shi-Yi Liu, Po Huang, Ning Zhang

Xuebijing injection for acute organophosphorus pesticide poisoning: a systematic review and meta-analysis

Po Huang, Bo Li, Shuo Feng, Yuhong Guo, Guozhen Zhao, Dongdong Wang, Qingquan Liu

Receptor-interacting protein kinase 3 as a predictive adjuvant chemotherapy marker after lung adenocarcinoma resection

Jae Heun Chung, Seong Hoon Yoon, Yong Jung Kang, Yun Seong Kim, Bong Soo Son, Ryuk Jun Kwon, Jun Hee Han, Do Hyung Kim

Medium-term outcome of cementless, mobile-bearing, unicompartmental knee arthroplasty

Radosław Stempin, Kacper Stempin, Wiesław Kaczmarek

A nationwide comparative analysis of medical complications in fibromyalgia patients following total knee arthroplasty

Tara Moore, Nipun Sodhi, Angad Kalsi, Rushabh M. Vakharia, Joseph O. Ehiorobo, Hiba K. Anis, Kristina Dushaj, Vivian Papas, Giles Scuderi, Scott Nelson, Martin W. Roche, Michael A. Mont

Discharge to the skilled nursing facility: patient risk factors and perioperative outcomes after total knee arthroplasty

Prem N. Ramkumar, Chukwuweike Gwam, Sergio M. Navarro, Heather S. Haeberle, Jaret M. Karnuta, Ronald E. Delanois, Michael A. Mont

Short-term outcomes after anatomic total shoulder arthroplasty in patients with osteoarthritis versus osteonecrosis

Sergio M. Navarro, Heather S. Haeberle, Anton Khlopas, Jared Newman, Jaret M. Karnuta, Michael A. Mont, Prem N. Ramkumar

Predictors of blood transfusion and in-hospital outcomes in patients with gastric antral vascular ectasia (GAVE): a nationwide population-based analysis

Upenkumar Patel, Rupak Desai, Jiten Desai, Nanush Damarlapally, Dipen Zalavadia, Mohamad Yousef, Roxana Coman, Pardeep Bansal, Hemant Goyal

High performance of intravoxel incoherent motion diffusion MRI in detecting viral hepatitis-b induced liver fibrosis

Hua Huang, Nazmi Che-Nordin, Li-Fei Wang, Ben-Heng Xiao, Olivier Chevallier, Yong-Xing Yun, Sheng-Wen Guo, Yì Xiáng J. Wáng

Preoperative thromboprophylactic administration of low-molecular-weight-heparin significantly decreased the risk of intraoperative bleeding compared with heparin in patients undergoing video-assisted lobectomy for lung cancer

Gu-Ha A-Lai, Yun-Ke Zhu, Gang Li, Me-Wu-Jia Mai-Ji, Han-Yu Deng, Jun Luo, Ze-Guo Zhuo, Xu Shen, Yi-Dan Lin

Computed tomography-guided dye localization for deeply situated pulmonary nodules in thoracoscopic surgery

Tung-Ming Tsai, Xu-Heng Chiang, Hsien-Chi Liao, Kuan-Chuan Tsou, Mong-Wei Lin, Ke-Cheng Chen, Hsao-Hsun Hsu, Jin-Shing Chen

An evaluation of adult critical result policies in haematology in a teaching hospital in China

Dagan Yang, Qian Cai, Xinglun Qi, Lili Xu, Yunxian Zhou

Recent fluorescence-based optical imaging for video-assisted thoracoscopic surgery segmentectomy

Yosuke Matsuura, Mingyon Mun, Junji Ichinose, Masayuki Nakao, Ken Nakagawa, Sakae Okumura

Co-expression of CD44/MyD88 is a poor prognostic factor in advanced epithelial ovarian cancer

Yi Zhu, Hongtao Zhang, Guonan Zhang, Yu Shi, Jianming Huang

Improved long-term survival following pulmonary resections for non-small cell lung cancer: results of a nationwide study from Iceland

Hannes Halldorsson, Andri Wilberg Orrason, Gudrun Nina Oskarsdottir, Astridur Petursdottir, Bjorn Mar Fridriksson, Magnus Karl Magnusson, Steinn Jonsson, Tomas Gudbjartsson

Case Report

Use of an offset head center acetabular shell in difficult primary total hip arthroplasties

Andrew J. Wassef, Anton Khlopas, Nipun Sodhi, Assem A. Sultan, Nicolas S. Piuzzi, Morad Chughtai, Kim L. Stearns, Robert Molloy, Michael A. Mont

Rare paraneoplastic erythroderma associated with ectopic neuron-specific enolase deposition in basal cells

Lei Wang, Ting Guo, Hao Zhang, Weimiao Li, Yifang Zhu, Haihua Guo, Feng Yang, Yitong Guo, Zhipei Zhang, Yong Han, Daixing Zhong, Xiaofei Li, Lijun Huang

Left lower lobe sleeve resection for endobronchial schwannoma

Hu Liao, Wenpeng Song, Nan Chen, Fengning Chen, Chengwu Liu, Feng Lin

A rare presentation of pleomorphic carcinoma of lung mimic empyema

Kuo-Ming Yang, En-Kuei Tang, Yih-Gang Goan, Yen-Chiang Tseng

Cardiac penetrating injury: a rare complication associated with the lung nodule localization by hookwire

Zhe Shi, Yuxing Jin, Chang Chen

Expert Consensus

Clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for sepsis

Guo-Zhen Zhao, Ren-Bo Chen, Bo Li, Yu-Hong Guo, Yan-Ming Xie, Xing Liao, Yu-Fei Yang, Teng-Fei Chen, Hao-Ran Di, Fei Shao, Xiao-Qin Lv, Jing Hu, Shuo Feng, Qing-Quan Liu, Bo-Li Zhang

Study Protocol

Acupuncture combined with herbal medicine versus herbal medicine alone for plaque psoriasis: a systematic review protocol

Shiju Xiao, Bo Li, Shuo Feng, Cunzhi Liu, Guangzhong Zhang

Efficacy and safety of Shen-Yuan-Dan capsules for peri-procedural myocardial injury following percutaneous coronary intervention: study protocol for a randomized, double-blind, placebo-controlled trial

Xiang Li, Xiao-Lei Lai, Yu-Tong Fei, Ju-Ju Shang, Qi Zhou, Xue-Yan Sun, Wen-Long Xing, Si-Han Jia, Hong-Xu Liu

Reading Companion: Blooming Flowers -A call for paper

Focus on “Novel Aspects in Ventilator-associated Pneumonia” edited by Dr. Saad Nseir and Dr. Ignacio Martin-Loeches

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Focus on “Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care” edited by Prof. Keith C. Ferdinand

Introduction of ATM “Corresponding Authors” Column

Focus on “Molecular Medicine” edited by Dr. Christina Piperi and Dr. Athanasios G. Papavassiliou

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

2017 Annual Report of ATM

Artificial Intelligence (AI) in Medicine: Evolving with the Times

Rare diseases: exploration never ceases

Testimonials for ATM from Eminent Experts Worldwide

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

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