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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)


A focused issue on pediatric acute respiratory distress syndrome
Jan Hau Lee, Martin Kneyber, Ira M. Cheifetz

Review Article

Definition and global epidemiology of pediatric acute respiratory distress syndrome
Fernando Beltramo, Robinder G. Khemani
Lessons learned in acute respiratory distress syndrome from the animal laboratory
Nadir Yehya
Insights into the immuno-pathogenesis of acute respiratory distress syndrome
Judith Ju Ming Wong, Jing Yao Leong, Jan Hau Lee, Salvatore Albani, Joo Guan Yeo
Biomarkers in pediatric acute respiratory distress syndrome
Erin F. Carlton, Heidi R. Flori
Ventilator-induced lung injury in children: a reality?
Alette A. Koopman, Pauline de Jager, Robert G. T. Blokpoel, Martin C. J. Kneyber
The role of point-of-care ultrasound in pediatric acute respiratory distress syndrome: emerging evidence for its use
Samantha K. Potter, Michael J. Griksaitis
Steroids in pediatric acute respiratory distress syndrome
Nicolás Monteverde-Fernández, Federico Cristiani, Jenniffer McArthur, Sebastián González-Dambrauskas
Sedation strategies in children with pediatric acute respiratory distress syndrome (PARDS)
Lynne Rosenberg, Chani Traube
What do we know about optimal nutritional strategies in children with pediatric acute respiratory distress syndrome?
Rajalakshmi Iyer, Arun Bansal
Transfusion in children with acute respiratory distress syndrome
Tine François, Guillaume Emeriaud, Oliver Karam, Marisa Tucci
Extra-corporeal membrane oxygenation in paediatric acute respiratory distress syndrome: overrated or underutilized?
Simon Erickson
Pertinent clinical outcomes in pediatric survivors of pediatric acute respiratory distress syndrome (PARDS): a narrative review
Siew Wah Lee, Sin Wee Loh, Chengsi Ong, Jan Hau Lee
Clinical trials and future directions in pediatric acute respiratory distress syndrome
Veerajalandhar Allareddy, Ira M. Cheifetz


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Big-data Clinical Trial Column

Expert Consensus

Expert consensus on spontaneous ventilation video-assisted thoracoscopic surgery in primary spontaneous pneumothorax (Guangzhou)
Jianxing He, Jun Liu, Chengchu Zhu, Tianyang Dai, Kaican Cai, Zhifeng Zhang, Chao Cheng, Kun Qiao, Xiang Liu, Guangsuo Wang, Shun Xu, Rusong Yang, Junqiang Fan, Hecheng Li, Jiang Jin, Qinglong Dong, Lixia Liang, Jinfeng Ding, Kaiming He, Yulin Liu, Jing Ye, Siyang Feng, Yu Jiang, Haoda Huang, Huankai Zhang, Zhenguo Liu, Xia Feng, Zhaohua Xia, Mingfei Ma, Zhongxin Duan, Tonghai Huang, Yali Li, Qiming Shen, Wenfei Tan, Hong Ma, Yang Sun, Congcong Chen, Fei Cui, Wei Wang, Jingpei Li, Zhexue Hao, Hui Liu, Wenhua Liang, Xusen Zou, Hengrui Liang, Hanyu Yang, Yingfen Li, Shunjun Jiang, Calvin S. H. Ng, Diego González-Rivas, Eugenio Pompeo, Raja M. Flores, Yaron Shargall, Mahmoud Ismail, Benedetta Bedetti, Ahmed G. Elkhouly, Keng Ang

Editorial Commentary

iMDT Corner

Liver News Column

Original Article

Review Article

Study Protocol

Functional magnetic resonance imaging-based assessment of terlipressin vs. octreotide on renal function in cirrhotic patients with acute variceal bleeding (CHESS1903): study protocol of a multicenter randomized controlled trial
Xinwen Yan, Ruoyang Shao, Yuancheng Wang, Xiaorong Mao, Junqiang Lei, Liting Zhang, Jianjun Zheng, Aimin Liu, Huimin Zhao, Fengxiao Gao, Jitao Wang, Ping Li, Shengjuan Yao, Ming Xu, Jian Xu, Dengxiang Liu, Yuqiang Mi, Xijun Gong, Jun Ye, Mingming Deng, Tong Dang, Jiansong Ji, Chuxiao Shao, Chao Liu, Ye Gu, Yunhong Wu, Fengmei Wang, Gaojun Teng, Xun Li, Xingshun Qi, Shenghong Ju, Xiaolong Qi

Special Report