About atm

Manuscript Submission


Contact us

Focused Issues more

Focus on “Innovations and Technology in Surgery” More >>
Focus on the 20th Panhellenic Congress organized under the auspices of the: “Hellenic Society... More >>
Focus on “Treatment for Hepatitis B” More >>


Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Sponsored by

Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

Sponsored by

Preface on Acute Lung Injury

Paul A. J. Beckers, Paul E. Van Schil

Review Article on Acute Lung Injury

Lung ischemia reperfusion injury: the therapeutic role of dipeptidyl peptidase 4 inhibition
Paul A. J. Beckers, Jan F. Gielis, Paul E. Van Schil, Dirk Adriaensen
The expression of proline-specific enzymes in the human lung
Gwendolyn Vliegen, Tom K. Raju, Dirk Adriaensen, Anne-Marie Lambeir, Ingrid De Meester
Oxidative and nitrosative stress during pulmonary ischemia-reperfusion injury: from the lab to the OR
Jan F. Gielis, Paul A. J. Beckers, Jacco J. Briedé, Paul Cos, Paul Ey Van Schil
Animal models of hospital-acquired pneumonia: current practices and future perspectives
Kenny Bielen, Bart’S Jongers, Surbhi Malhotra-Kumar, Philippe G. Jorens, Herman Goossens, Samir Kumar-Singh

Original Article

Category 1 external quality assessment program for serum creatinine
Elisabet González-Lao, Jorge Díaz-Garzón, Zoraida Corte, Carmen Ricós, Carmen Perich, Virtudes Álvarez, Margarita Simón, Joana Minchinela, José Vicente García-Lario, Beatriz Boned, Carmen Biosca, Fernando Cava, Pilar Fernández-Fernández, Pilar Fernández-Calle
Early outcomes of exon 11 mutants in GIST treated with standard dose Imatinib
Anant Ramaswamy, Munita Bal, Rohit Swami, Omshree Shetty, Subhadeep Bose, Trupti Pai, Mamta Gurav, Sudeep Gupta, Vikas Ostwal
Condylar constrained system in primary total knee replacement: our experience and literature review
Luigi Sabatini, Salvatore Risitano, Lorenzo Rissolio, Andrea Bonani, Francesco Atzori, Alessandro Massè


Nexus between extracellular vesicles, immunomodulation and tissue remodeling: for good or for bad?
Farah Fatima, Muhammad Nawaz
Optimal medical therapy is vital for patients with coronary artery disease and acute coronary syndromes regardless of revascularization strategy
Javaid Iqbal, Patrick W. Serruys
Incomplete surgical ligation of the left atrial appendage—time for a new look at an old problem
Arash Aryana, Rohit Bhaskar
The Ross procedure: time for a hard look at current practices and a reexamination of the guidelines
Ismail El-Hamamsy, Ismail Bouhout
Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: piece by piece
David J. Lundy, Desy S. Lee, Patrick C.H. Hsieh
The impact of frailty on mortality after transcatheter aortic valve replacement
Charat Thongprayoon, Wisit Cheungpasitporn, Kianoush Kashani
The chicken or the egg dilemma: intestinal dysbiosis in multiple sclerosis
Javier Ochoa-Repáraz, Krisztian Magori, Lloyd H. Kasper
Preventive post-extubation high-flow nasal oxygen therapy versus non-invasive ventilation: a substitutive or a complementary ventilatory strategy?
Christophe Girault, Gaëtan Béduneau, Dorothée Carpentier, Benoît Misset
The importance of being ncRNAs: from bit players as “junk DNA” to rising stars on the stage of the pharmaceutical industry
Vittoria Di Mauro, Daniele Catalucci
The discovery of HLA-G-bearing extracellular vesicles: new perspectives in HLA-G biology
Giada Amodio, Silvia Gregori
How evidenced based and up to date are our cough guidelines?
Michael D Shields
On the function and heterogeneity of extracellular vesicles
Bernd Giebel
Causal variants in autoimmune disease: a commentary on a recent published fine-mapping algorithm analysis in genome-wide association studies study
Jiunn-Diann Lin, Chao-Wen Cheng

Letter to the Editor

Practical and theoretical implications of weight gain in advanced non-small cell lung cancer patients
Philip Bonomi, Marta Batus, Mary Jo Fidler, Jeffrey A. Borgia


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.




Review Article

Original Article

Case Report

Review Article on Treatment for Hepatitis B