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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

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the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Original Article

Blood pressure targets for hypertension in patients with type 2 diabetes
Wilbert S. Aronow, Tatyana A. Shamliyan
Trends of snowboarding-related fractures that presented to emergency departments in the United States, 2010 to 2016
Aleksey Seleznev, Neil V. Shah, Rohan Desai, Cuong Le, Patrick Cleary, Qais Naziri, Niladri N. Basu, Barbara J. Freeman, William P. Urban, Jared M. Newman
The efficacy of first-line chemotherapy in recurrent or metastatic nasopharyngeal carcinoma: a systematic review and metaanalysis
Shu-Xiang Ma, Ting Zhou, Yan Huang, Yun-Peng Yang, Jian-Hua Zhan, Ya-Xiong Zhang, Zhong-Han Zhang, Yuan-Yuan Zhao, Wen-Feng Fang, Yu-Xiang Ma, Li-Kun Chen, Hong-Yun Zhao, Li Zhang
Cervical or thoracic anastomosis for patients with cervicothoracic esophageal squamous cell carcinoma
Ran Mo, Chen Chen, Liang Pan, Ao Yu, Tao Wang
Compensatory hyperhidrosis after different surgeries at the same sympathetic levels: a meta-analysis
Xiaojun Du, Xu Zhu, Tao Wang, Xiao Hu, Peng Lin, Yin Teng, Chao Fan, Jianglun Li, Yang Xi, Jiarong Xiao, Wen Liu, Jian Zhang, Haiyu Zhou, Dan Tian, Shizhang Yuan
Short-term outcomes for total knee arthroplasty patients with active extension lag
Tanner L. McGinn, Jennifer I. Etcheson, Chukwuweike U. Gwam, Nicole E. George, Nequesha S. Mohamed, Jaydev B. Mistry, Ugochi Ananaba, Anil Bhave
Physical activity levels are low in patients with pulmonary hypertension
Laura González-Saiz, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Paz Sanz-Ayán, Carlos A. Quezada-Loaiza, Ana Ruiz-Casado, Lidia B. Alejo, Angela Flox-Camacho, María Morán, Alejandro Lucia, Pilar Escribano-Subías
Impact of polymyxin B hemoperfusion in the treatment of patients with sepsis and septic shock: a meta-analysis of randomized controlled trials
Akira Kuriyama, Morihiro Katsura, Seigo Urushidani, Tadaaki Takada
Increasing clinical resistance rate of Shigella sonnei to cefotaxime in Jiangsu Province, China, between 2012 and 2015
Huimin Qian, Guoye Liu, Yin Chen, Ping Ma, Xiaoxiao Kong, Lu Zhou, Jie Hong, Changjun Bao, Bing Gu
Study on factors affecting local peak strain results in automatic functional imaging of transthoracic echocardiography
Na Li, Linbin Meng, Yichen Wang, Kailing Xiong, Junxuan He, Yang Wang, Yifu Qiao, Attila Nemes, Raffaele Giordano, Lang Qiao, written on behalf of AME Echocardiography Collaborative Group
miR-486 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells
Jin Li, Qiulian Zhou, Yajun Liang, Wen Pan, Yihua Bei, Yuhui Zhang, Jinhua Wang, Zheng Jiao

Review Article

Surgery for intrathoracic tracheoesophageal and bronchoesophageal fistula
Benoit Jacques Bibas, Paulo Francisco Guerreiro Cardoso, Helio Minamoto, Paulo Manoel Pêgo-Fernandes

Surgical Technique

Development and clinical applications of glasses-free three-dimensional (3D) display technology for thoracoscopic surgery
Jun Liu, Fei Cui, Jingpei Li, Wenlong Shao, Wei Wang, Jun Li, Muchun Liu, Jianxing He

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Big-data Clinical Trial Column

Opening the black box of neural networks: methods for interpreting neural network models in clinical applications
Zhongheng Zhang, Marcus W. Beck, David A. Winkler, Bin Huang, Wilbert Sibanda, Hemant Goyal, written on behalf of AME Big-Data Clinical Trial Collaborative Group

Editorial

Aspirin and diabetes mellitus in primary prevention: the Endless Conundrum
Rubén Casado-Arroyo
Low-dose aspirin for primary cardiovascular prevention in diabetic patients: the issue to believe it or not
Priscilla Lamendola, Angelo Villano, Augusto Fusco, Massimo Leggio
Quality of life and treatment satisfaction are highly relevant patient-reported outcomes in type 2 diabetes mellitus
Didac Mauricio
Multi-drug therapy in breast cancer: are there any alternatives?
Partha Mitra
Which criteria should we use to evaluate the efficacy of immunecheckpoint inhibitors?
Yuki Kataoka, Katsuya Hirano
An important piece of the puzzle for understanding the benefits of concomitant ablation of atrial fibrillation in cardiac surgery
Anders Albåge
Policy and governance solutions for ensuring equitable access to cancer medicines in low- and middle-income countries
Raphael E. Cuomo, Tim K. Mackey
The uremic solute-AHR-tissue factor axis in vascular cells, mouse models and thrombosis in chronic kidney disease patients
Nigel Mackman, Jonathan H. Erlich
Is effective the hyperbaric oxygen therapy for the treatment of ischemic lower extremity ulcers?—new insights from a multicenter study
Bruno Rivas-Santiago
Building a cultural alliance for the prevention of fragility fractures among high risk older adults
Marta Baroni, Valentina Prenni, Carmelinda Ruggiero
Hyperbaric oxygen for treatment of diabetic foot ulcers: love you more than I can say
Qinan Wu
Optimal regimen of cisplatin in squamous cell carcinoma of head and neck yet to be determined
Xiuning Le, Ehab Y. Hanna
Gene-expression signature may be useful for the prediction of lymph node metastasis in esophageal cancer
Yoshifumi Baba, Hideo Baba
The search for surrogate endpoints for immunotherapy trials
Marc Buyse, Tomasz Burzykowski, Everardo D. Saad
BLU-285—the breakthrough in treatment of patients with aggressive systemic mastocytosis and gastrointestinal stromal tumor
Regine Schneider-Stock
Noninvasive cancer biomarkers in solid malignancies: circulating tumor DNA—clinical utility, current limitations and future perspectives
Debora de Melo Gagliato, Denis L. Fontes Jardim
Unmask the genetic backbone of ibrutinib-relapsed chronic lymphocytic leukemia progression and Richter transformation
Wei-Ge Wang, Xiao-Yan Zhou, Xiao-Qiu Li
The promise and challenges of chimeric antigen receptor T cells in relapsed B-cell acute lymphoblastic leukemia
Zhi-Chun Ding
Different prevalence and clinical outcome of Epstein-Barr virus positive diffuse large B-cell lymphoma between North American and non-Western populations
Lihui Yin, Zijun Y. Xu-Monette, Jay Brock, Yong Li, Ken H. Young
Revolutionary changes in salvage treatment for Hodgkin lymphoma: toward a chemotherapy-free future
Jiawen Chen, Wei Yang, Zimu Gong
Is there a place for the combination of brentuximab vedotin and bendamustine in treatment of patients with relapsed/refractory Hodgkin lymphoma?
Robert W. Chen

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal

Commentary

Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface



Review Article


Original Article


Case Report