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ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

Focus on “Inborn Errors of Metabolism” edited by Dr. Shibani Kanungo and Dr. Dilip R. Patel

Annals of Translation Medicine (ATM) focused issue: inborn errors of metabolism (IEM) is a one stop resource for all levels of learners from undergraduates interested in science to multiple subspecialties in the field of medicine, genetics and public health.

Reading Companion: Blooming Flowers -A call for paper

Parent's Comments: Huilongwo was built in the Qing Dynasty. It is now a historic and cultural district in Xuzhou, in the center of the city. The old building in the painting is a corner of Huilongwo. Generally, children’s life experience lacks deeper nuances to understand the historical implications of architecture, in this painting, you can still see traces of tranquillity and vicissitudes. The usage of colors in this gives the old building vitality.

Focus on “Novel Aspects in Ventilator-associated Pneumonia” edited by Dr. Saad Nseir and Dr. Ignacio Martin-Loeches

Ventilator-associated pneumonia (VAP) remains an important clinical problem, being associated with significant morbidity and mortality. In this special issue of Annals of Translational Medicine, novel aspects regarding definition, diagnosis, epidemiology, and treatment of VAP are discussed by experts in this field.

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

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Vol 7, No 5 (March, 2019)

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Focused Issues more

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” More >>

Focus on “Inborn Errors of Metabolism” More >>

Focus on “Novel Aspects in Ventilator-associated Pneumonia” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial Commentary

Mesenchymal stem cell therapy for neonatal intraventricular hemorrhage: a long way to go?

Shinya Abe, Kazumichi Fujioka

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Comprehensive genomic analysis of circulating tumor DNA for patients with advanced non-small cell lung cancer

Delphine Lissa, Ana I. Robles

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New genetic characteristics of latent autoimmune diabetes in adults (LADA)

Yan Chen, Gang Chen

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Modern human lifestyle prejudices epigenetic changes to cuddle diseases

Narasimman Gurusamy, Johnson Rajasingh

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Long-acting glucagon-like peptide-1 receptor agonist—status December 2018

Jens Juul Holst

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Is active surveillance an option for metachronous metastatic renal cell carcinoma?

Vincenzo Ficarra, Alessandra Mosca, Marta Rossanese, Enrica Subba, Gianluca Giannarini

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Percutaneous coronary intervention in left main disease: 10-year follow-up

Akihiro Kobayashi, Naoki Misumida

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Extracellular vesicles in hepatocellular cancer and cholangiocarcinoma

Feihu Xie, Shi Feng, Huayu Yang, Yilei Mao

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Can presepsin be used for screening invasive fungal infections?

Giuseppe Lippi, Gianfranco Cervellin

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Original Article

Improved long-term survival following pulmonary resections for non-small cell lung cancer: results of a nationwide study from Iceland

Hannes Halldorsson, Andri Wilberg Orrason, Gudrun Nina Oskarsdottir, Astridur Petursdottir, Bjorn Mar Fridriksson, Magnus Karl Magnusson, Steinn Jonsson, Tomas Gudbjartsson

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Systematic identification of key genes and pathways in clear cell renal cell carcinoma on bioinformatics analysis

Zhao-Hui Tian, Cheng Yuan, Kang Yang, Xing-Liang Gao

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Preoperative thromboprophylactic administration of low-molecular-weight-heparin significantly decreased the risk of intraoperative bleeding compared with heparin in patients undergoing video-assisted lobectomy for lung cancer

Gu-Ha A-Lai, Yun-Ke Zhu, Gang Li, Me-Wu-Jia Mai-Ji, Han-Yu Deng, Jun Luo, Ze-Guo Zhuo, Xu Shen, Yi-Dan Lin

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Co-expression of CD44/MyD88 is a poor prognostic factor in advanced epithelial ovarian cancer

Yi Zhu, Hongtao Zhang, Guonan Zhang, Yu Shi, Jianming Huang

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Mid-term outcomes of titanium modular neck femoral stems in revision total hip arthroplasty

Hervé Ouanezar, Thomas Jalaguier, Florent Franck, Vincent Pibarot, Hugo Bothorel, Mo Saffarini, Jean-Pierre Piton

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Significant association of CD4⁺CD25⁺Foxp3⁺ regulatory T cells with clinical findings in patients with systemic lupus erythematosus

Xiaofan Yang, Weiwen Wang, Juan Xu, Ming-Shun Zhang, Huanping Mei, Youxuan Shen, Miao-Jia Zhang, Xiaohui Ji, Huijuan Wang

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Association between carotid plaque and Parkinson’s disease

Lan-Yun Yan, Qing-Fang He, Min-Yan Lu, Sheng-Long Wang, Zhi-Qiang Qi, Hai-Rong Dong

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Clinical significance of pretreatment tumor growth rate for locally advanced non-small cell lung cancer

Benedict Osorio, Nikhil Yegya-Raman, Sinae Kim, Charles B. Simone II, Christina Theodorou Ross, Matthew P. Deek, Dakim Gaines, Wei Zou, Liyong Lin, Jyoti Malhotra, Ke Nie, Joseph Aisner, Salma K. Jabbour

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Protective effect of intraoperative re-dose of prophylactic antibiotics on surgical site infection in diabetic patients: a retrospective cohort study

Xu Zhang, Tan Li, Yan Li, Miao He, Ya-Qi Liu, Meng-Ying Wang, Shi-Jie Xin, Qun Zhao

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Intermittent hypoxia enhances the tumor programmed death ligand 1 expression in a mouse model of sleep apnea

Mao-Hong Huang, Xiao-Bin Zhang, Hui-Ling Wang, Liu-Xia Li, Yi-Ming Zeng, Miao Wang, Hui-Qing Zeng

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Is severe re-expansion pulmonary edema still a lethal complication of closed thoracostomy or thoracic surgery?

Sang Kwon Lee, Jung Joo Hwang, Mi Hee Lim, Joo Hyung Son, Do Hyung Kim

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Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis

Man-Man Han, Jin-Fang Sun, Xiang-Hui Su, You-Fan Peng, Hemant Goyal, Chun-Hua Wu, Xiang-Yun Zhu, Ling Li

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Clinicopathological characteristics and treatment strategies for young lung cancer patients

Remi Yoneyama, Hisashi Saji, Yasufumi Kato, Yujin Kudo, Yoshihisa Shimada, Masakazu Kimura, Masaru Hagiwara, Masatoshi Kakihana, Kuniharu Miyajima, Naohiro Kajiwara, Tatsuo Ohira, Harubumi Kato, Norihiko Ikeda

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Broncholithiasis: retrospect of 15 surgical treatment patients

Dongliang Bian, Peng Zhang, Huibiao Zhang, Ke Fei

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Outcomes of transcatheter aortic valve replacement in bicuspid aortic valve stenosis

Tamunoinemi Bob-Manuel, Mark R. Heckle, Ikechukwu A. Ifedili, Jiajing Wang, Uzoma N. Ibebuogu

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Risk factors associated with prolonged air leak after video-assisted thoracic surgery pulmonary resection: a predictive model and meta-analysis

Huiyu Pan, Ruimin Chang, Yanwu Zhou, Yang Gao, Yuanda Cheng, Chunfang Zhang

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Which induction chemotherapy regimen followed by cisplatin-based concurrent chemoradiotherapy is the best choice among PF, TP and TPF for locoregionally advanced nasopharyngeal carcinoma?

Yan He, Tao Guo, Jingjing Wang, Yu Sun, Hui Guan, Shaoyong Wu, Xingchen Peng

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Review Article

NK-mediated antibody-dependent cell-mediated cytotoxicity in solid tumors: biological evidence and clinical perspectives

Cristiana Lo Nigro, Marco Macagno, Dario Sangiolo, Luca Bertolaccini, Massimo Aglietta, Marco Carlo Merlano

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Case Report

Ceritinib-related interstitial lung disease improving after treatment cessation without recurrence under either crizotinib or brigatinib: a case report

Laura Bender, Guillaume Meyer, Elisabeth Quoix, Bertrand Mennecier

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Hemorrhagic bulla: a rare presentation of scabies

Lan-Ying Li, Hong Sun, Xiao-Ying Li, Juan-Hua Liu, Wen-Xing Liu, Di-Qing Luo

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A case of recurrent hemoptysis caused by pulmonary actinomycosis diagnosed using transbronchial lung biopsy after bronchial artery embolism and a brief review of the literature

Manabu Suzuki, Kyoko Araki, Sachi Matsubayashi, Konomi Kobayashi, Eriko Morino, Jin Takasaki, Motoyasu Iikura, Shinyu Izumi, Yuichiro Takeda, Haruhito Sugiyama

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Letter to the Editor

Beneficiality of levosimendan for Takotsubo syndrome remains uncertain

Josef Finsterer, Claudia Stöllberger

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Meet the Professor

Experience in article writing about academic research and social issues

Elva S. Zheng

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Editorial for focused issue “Wilson Disease: From Genetics to Management of Disease”

Ralf Weiskirchen, Wolfgang Stremmel

Tumors of the spine and spinal cord

Matthew L. Goodwin, Daniel M. Sciubba

Editorial

Is the onset of adverse effects of immunotherapy always bad news for the patients…?—certainly not!

Paul Hofman

Fluorescence-guided surgery in cancer treatment: current status and future perspectives

Yongchang Zheng, Huayu Yang, Henan Wang, Kai Kang, Wenkai Zhang, Gang Ma, Shunda Du

Meningeal lymphatics in aging and Alzheimer’s disease

Russell J. Jaffe, Rajnish S. Dave, Siddappa N. Byrareddy

Pathophysiology of pain in patients with peritoneal endometriosis

Simone Ferrero, Valerio Gaetano Vellone, Fabio Barra

Eighth edition of the American Joint Committee on Cancer staging system for soft tissue sarcoma of the trunk and extremity: in search of a better staging system

Kazuhiro Tanaka, Hiroshi Tsumura

Pembrolizumab in advanced gastric cancer: pioneering or prosaic?

Sarbajit Mukherjee, Steven N. Hochwald

Patient centered care for prostate cancer—how can artificial intelligence and machine learning help make the right decision for the right patient?

Nathan C. Wong, Bobby Shayegan

Improving detection combined with targeted therapy for small hepatocellular carcinoma

Shengyang Qiu, Long R. Jiao

American Joint Committee on Cancer 8^th edition staging—an improvement in prognostication in HPV-associated oropharyngeal cancer?

Jon Mallen-St Clair, Allen S. Ho

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Cancer staging for rare cancers: should the American Joint Committee on Cancer have a separate staging classification for external auditory canal cancer?

Jonathan Robert Clark, Hubert Low, Ruta Gupta

Monocyte-platelet cross-talk in peripheral artery disease—how much does the pathogenesis of atherosclerosis depend on anatomical location?

Richard A. Brown, Gregory Y. H. Lip

Pembrolizumab for recurrent/metastatic head and neck cancer: equally promising for Asian patients?

Wenda Ye, Nicole C. Schmitt

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

The use of baseline tumor size to prognosticate overall survival in stage IV melanoma patients treated with the PD-1 inhibitor pembrolizumab

Philip Friedlander

Immunotherapeutic strategies in patients with advanced head and neck squamous cell carcinoma

Maysaloun Merhi, Afsheen Raza, Varghese Inchakalody, Abdul Rahman Zar, Shahab Uddin, Said Dermime

Single nucleotide polymorphisms in angiogenesis-related genes and outcomes from antiangiogenic therapies in renal cell carcinoma: really a step towards personalized oncology, or not at all?

Camillo Porta, Laura Cosmai, Mimma Rizzo, Mario Melazzini

There is another new method for cryopreserving small numbers of human sperm cells

Alessio Paffoni, Simone Palini

Nanoparticles as theranostic vehicles in prostate cancer

Rafael Morales-Barrera, Cristina Suárez, Joaquín Mateo, Macarena González, Joan Carles

Orphan noncoding RNAs: novel regulators and cancer biomarkers

Mona Teng, Lydia Y. Liu, Junjie Tony Hua, Sujun Chen, Housheng Hansen He

A nomogram for predicting survival of patients with locally advanced pancreatic cancer treated with chemoradiotherapy: an editorial comment

Joyce Wong

Mitochondrial cytochrome c oxidase is not the primary acceptor for near infrared light—it is mitochondrial bound water: the principles of low-level light therapy

Andrei P. Sommer

Ultrasound patterns of pulmonary edema

Gino Soldati, Marcello Demi, Libertario Demi

Mind the gap: renal tubule responses to injury and the role of Cxcl12 and Myc

Veronika Sander, Richard W. Naylor, Alan J. Davidson

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Electronic health records, physician workflows and system change: defining a pathway to better healthcare

Carla M. Pugh

Important caveats of KEYNOTE-045: relevance of these findings in the current and future therapeutic paradigm

Julio Slongo, Rohit K. Jain, Philippe E. Spiess

Norepinephrine, more than a vasopressor

Emilio Daniel Valenzuela Espinoza, Glenn Hernandez, Jan Bakker

Anterior knee pain as a functional problem of complex dynamic inter-play of living structures

Werner Müller

The variables of force generation and application to cartilage, ligaments and bone remain to be defined

Robert A. Teitge

Editorial on “Risk prediction models for cancer-specific survival following cytoreductive nephrectomy in the contemporary era”

Yasmin Abu-Ghanem, Jacob Ramon

UICC and AJCC 8th edition tumor-nodes-metastasis (TNM) classifications for patients treated with radical prostatectomy: reliable but not infallible prognostic tools

Marco Bandini, Felix Preisser

Adjuvant therapy in renal cell carcinoma—Is pharmacogenomics assessment another element to select our patients?

Vincenzo Di Nunno, Veronica Mollica, Lidia Gatto, Matteo Santoni, Giulia Sorgentoni, Nicola Battelli, Francesco Massari

The potential role of germline single nucleotide polymorphisms for selecting the ideal candidates for sunitinib therapy in patients with locally-advanced renal cell carcinoma

Alberto Martini, Reza Mehrazin

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Chronic obstructive pulmonary disease alters immune cell composition and immune checkpoint inhibitor efficacy in nonsmall cell lung cancer

Marcos Magalhães Filho, Pedro N. Aguiar Jr, Ramon Andrade de Mello

Anatomy is not enough: the crucial role of biology and genetics in AJCC eighth edition of the TNM classification for breast cancer

Francesca Magnoni, Giuseppe Accardo, Elisabetta Rossi, Paolo Veronesi, Giovanni Corso

When survival curves cross: are we at a crossroads of immunotherapy in gastric cancer?

Jun Gong, Joseph Chao

Potential biological and clinical benefit of prostate-directed interventions in patients with metastatic prostate cancer

Makito Miyake, Takuya Owari, Nobumich Tanaka, Kiyohide Fujimoto

Stem cell therapy in diabetic men with erectile dysfunction: a step closer to safe and effective regenerative technology

Eric Chung

Lactate as a key metabolic intermediate in cancer

L. Bruce Gladden

Is an immune checkpoint inhibitor really a hopeless therapeutic choice for EGFR-mutant non-small cell lung cancer (NSCLC) patients?

Kei Kunimasa, Kazumi Nishino, Toru Kumagai

Perspective

Perspectives of value-based policy making in child health care in Japan

Ruoyan Gai Tobe, Hiroshi Fuji, Hirohito Metoki, Akira Ehara, Tsuguhiko Kato, Hakuyo Ebara, Toshihiko Nishida, Gen Kobashi, Rintaro Mori

Review Article

Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma mass spectrometry

Sabine Weiskirchen, Philipp Kim, Ralf Weiskirchen

Wilson disease—treatment perspectives

Tomasz Litwin, Karolina Dzieżyc, Anna Członkowska

Clinical practice guidelines in Wilson disease

Chiara Saroli Palumbo, Michael L. Schilsky

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Cerebrospinal fluid leaks after spine tumor resection: avoidance, recognition and management

Sean M. Barber, Jared S. Fridley, Sanjay Konakondla, Jonathan Nakhla, Adetokunbo A. Oyelese, Albert E. Telfeian, Ziya L. Gokaslan

Systematic review on the utility of magnetic resonance imaging for operative management and follow-up for primary sarcoma—lessons from extremity sarcomas

Zach Pennington, A. Karim Ahmed, Ethan Cottrill, Erick M. Westbroek, Matthew L. Goodwin, Daniel M. Sciubba

Clinical features of Wilson disease

Wolfgang Stremmel, Uta Merle, Ralf Weiskirchen

Classification and differential diagnosis of Wilson’s disease

Wieland Hermann

Lactate and cancer: spinal metastases and potential therapeutic targets (part 2)

Zach Pennington, Matthew L. Goodwin, Erick M. Westbroek, Ethan Cottrill, A. Karim Ahmed, Daniel M. Sciubba

Anti-inflammatory therapy for cardiovascular disease

Constantine E. Kosmas, Delia Silverio, Andreas Sourlas, Peter D. Montan, Eliscer Guzman, Mario J. Garcia

Total en bloc resection of primary and metastatic spine tumors

Elizabeth P. Howell, Theresa Williamson, Isaac Karikari, Muhammad Abd-El-Barr, Melissa Erickson, Matthew L. Goodwin, Jeremy Reynolds, Daniel M. Sciubba, C. Rory Goodwin

Clinical management of Wilson disease

Peter Hedera

Lactate and cancer: a “lactatic” perspective on spinal tumor metabolism (part 1)

Matthew L. Goodwin, Zach Pennington, Erick M. Westbroek, Ethan Cottrill, A. Karim Ahmed, Daniel M. Sciubba

Preclinical models of Wilson’s disease, why dogs are catchy alternatives

Hedwig S. Kruitwagen, Louis C. Penning

The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer

Udit Chaddha, D. Kyle Hogarth, Septimiu Murgu

Challenges in the diagnosis of Wilson disease

Aurélia Poujois, France Woimant

Current anti-copper therapies in management of Wilson disease

Isabelle Mohr, Karl Heinz Weiss

Liquid biopsy for lung cancers: an update on recent developments

Alberto E. Revelo, Alvaro Martin, Ricardo Velasquez, Prarthna Chandar Kulandaisamy, Jean Bustamante, Sevak Keshishyan, Gregory Otterson

Clinical manifestations of Wilson disease in organs other than the liver and brain

Karolina Dzieżyc-Jaworska, Tomasz Litwin, Anna Członkowska

Original Article

Long-term effects of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: systematic review and single-arm meta-analyses

Zongshi Qin, Jiani Wu, Chang Xu, Xiaopu Sang, Xiao Li, Guangrui Huang, Zhishun Liu

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI

Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models

John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann

Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging

Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric K. Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael

A real-world study on adverse drug reactions to Xuebijing injection: hospital intensive monitoring based on 93 hospitals (31,913 cases)

Rui Zheng, Hui Wang, Zhi Liu, Xiaohui Wang, Jing Li, Xiang Lei, Yilin Fan, Si Liu, Zhiqiao Feng, Hongcai Shang

Using meta-regression approach to explore the dose-response association between acupuncture sessions and acupuncture effects on chronic prostatitis/chronic pelvic pain syndrome

Zongshi Qin, Jiani Wu, Chang Xu, Zhishun Liu

Random forest can accurately predict the development of end-stage renal disease in immunoglobulin a nephropathy patients

Xin Han, Xiaonan Zheng, Ying Wang, Xiaoru Sun, Yi Xiao, Yi Tang, Wei Qin

Validity and reliability of patient section of evidence-based medical records about doctor-patient building through integrated therapy of traditional Chinese and Western medicine (DPEBMR-P) in patients with gastrointestinal diseases

Shuo Feng, Lingxiao Chen, Guihua Tian, Jing Hu, Yang Ding, Zhengguang Du, Hongkai Zhang, Bo Li, Yang Li

Efficacy and safety of the Fu-Zheng-Qu-Zhuo method on retarding the progress of chronic kidney disease (stage 3–4): a systematic review and meta-analysis

Shi-Yi Liu, Po Huang, Ning Zhang

Xuebijing injection for acute organophosphorus pesticide poisoning: a systematic review and meta-analysis

Po Huang, Bo Li, Shuo Feng, Yuhong Guo, Guozhen Zhao, Dongdong Wang, Qingquan Liu

Tumor location is an independent prognostic factor of esophageal adenocarcinoma based on the eighth edition of TNM staging system in Chinese patients

Han-Yu Deng, Xi Zheng, Guha Alai, Gang Li, Jun Luo, Ze-Guo Zhuo, Yi-Dan Lin

Adverse drug reactions of Yunnan Baiyao capsule: a multi-center intensive monitoring study in China

Bo Li, Shuo Feng, Zhi-Hong Wu, Joey S. W. Kwong, Jing Hu, Nan Wu, Gui-Hua Tian, Hong-Cai Shang, Gui-Xing Qiu

Intra- and interobserver reliability of the Spinal Instability Neoplastic Score system for instability in spine metastases: a systematic review and meta-analysis

Zach Pennington, A. Karim Ahmed, Ethan Cottrill, Erick M. Westbroek, Matthew L. Goodwin, Daniel M. Sciubba

Using single-patient (n-of-1) trials to determine effectiveness of traditional Chinese medicine on chemotherapy-induced leukopenia in gastric cancer: a feasibility study

Jiang Li, Junqiang Niu, Min Yang, Peizhi Ye, Jingbo Zhai, Wenzhen Yuan, Li Feng, Guihua Tian, Jiayuan Hu, Yaohan Wang, Hongcai Shang

Routine intensive monitoring but not routine intensive care unit-based management is necessary in video-assisted thoracoscopic surgery lobectomy for lung cancer

Seung Eun Lee, Woo Hyun Cho, Sang Kwon Lee, Ki Sup Byun, Bong Soo Son, Doosoo Jeon, Yun Seong Kim, Hye Ju Yeo

STAG2 loss-of-function mutation induces PD-L1 expression in U2OS cells

Zhirui Nie, Wenwen Gao, Yan Zhang, Yuhe Hou, Jingxian Liu, Zhaoqiang Li, Wei Xue, Xidong Ye, Anmin Jin

The effect of walnut rolling training on hand function and corticospinal tract

Sung Ho Jang, Tae Ho Kim, Han Do Lee

M2 macrophages promote pulmonary endothelial cells regeneration in sepsis-induced acute lung injury

Yaxing Shen, Jieqiong Song, Yingqin Wang, Zhenglong Chen, Lin Zhang, Jie Yu, Duming Zhu, Ming Zhong

Quality in practice: implementation of a clinical outcomes registry in regenerative medicine

Frank Zackary Jenio, Corey Scholes, Maimuna Marenah, Jinjie Li, Mac Cowley, Milad Ebrahimi, Meredith Harrison-Brown, William D. Murrell

The reporting quality of acupuncture for neurogenesis in experimental ischemic stroke study

Zheng-Xiang Li, Yan Li, Wen-Ting Yang, Min Wang, Meng-Bei Xu, Xiao-Li Zhou, Pei-Qing Rong, Ting-Yu Jin, Wen-Jin Yi, Guo-Qing Zheng

Evaluation of the association between the −1304T>G polymorphism in the promoter of the MKK4 gene and the risk of colorectal cancer: a PRISMA-compliant meta-analysis

Rui Bai, Cheng Yuan, Fuxiang Zhou, Lihua Ni, Yan Gong, Conghua Xie

Retrospective study of the interlaminar approach for percutaneous endoscopic lumbar discectomy with the guidance of pre-operative magnetic resonance neurography

Yanhong Liu, Shengtao Wang, Congxian Yang, Bo Zhong, Siyan Zhang, Jian Li, Zhijian Fu

Effect of Bushen Huoxue decoction on inhibiting osteogenic differentiation of vascular smooth cells by regulating OPG/RANK/RANKL system in vascular calcification

Shi-Yi Liu, Xiang-Fei Meng, Shi-Wei Liu, Cong-Li Hao, Lan-Fang Li, Ning Zhang

AMBRA1-mediated autophagy and apoptosis associated with an epithelial-mesenchymal transition in the development of cleft palate induced by all-trans retinoic acid

Xuan Shu, Zejun Dong, Shenyou Shu

Deep learning based classification of ultrasound images for thyroid nodules: a large scale of pilot study

Qing Guan, Yunjun Wang, Jiajun Du, Yu Qin, Hongtao Lu, Jun Xiang, Fen Wang

Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer

Yueyao Du, Liheng Zhou, Yanping Lin, Kai Yin, Wenjin Yin, Jinsong Lu

Baseline serum lactate dehydrogenase level predicts survival benefit in patients with metastatic colorectal cancer receiving bevacizumab as first-line chemotherapy: a systematic review and meta-analysis of 7 studies and 1,219 patients

Wanjing Feng, Yue Wang, Xiaodong Zhu

Transplantation of dental tissue-derived mesenchymal stem cells ameliorates nephritis in lupus mice

Xiaojun Tang, Wenchao Li, Xin Wen, Zhuoya Zhang, Weiwei Chen, Genhong Yao, Hongwei Chen, Dandan Wang, Songtao Shi, Lingyun Sun

Enhancing autophagy protects platelets in immune thrombocytopenia patients

Chun-Yan Wang, Sai Ma, Shao-Jie Bi, Le Su, Shu-Ya Huang, Jun-Ying Miao, Chun-Hong Ma, Cheng-Jiang Gao, Ming Hou, Jun Peng

MicroRNA-200c-3p/ZEB2 loop plays a crucial role in the tumor progression of prostate carcinoma

Jiayi Zhang, Hengcheng Zhang, Yuan Qin, Chen Chen, Jie Yang, Ninghong Song, Min Gu

Case Report

Management of presacral schwannomas—a 10-year multi-institutional series

Zach Pennington, Clemens Reinshagen, A. Karim Ahmed, Sean Barber, Matthew L. Goodwin, Ziya Gokaslan, Daniel M. Sciubba

Pulmonary metastases of fibrosarcomatous dermatofibrosarcoma protuberans respond to apatinib-based angiogenesis and chemotherapy: a case report

Huimin Chen, Yongmei Liu, Feng Peng, Juan Huang, Xiang Wen, Zhenyu Ding, Shouyue Zhang, Yan Zhang, You Lu

Difficulties in diagnosis and treatment of Wilson disease—a case series of five patients

Anna Członkowska, Karolina Dzieżyc-Jaworska, Bożena Kłysz, Rędzia-Ogrodnik Barbara, Tomasz Litwin

Letter to the Editor

Is the Guytonian framework justified in explaining heart-lung interactions?

Rafael Dalmau

Visualized Surgery

The application of selective neck dissection while preserving the cutaneous branches of cervical plexus in the surgical treatment of differentiated thyroid cancer—experiences from thousands of cases

Ning Qu, Ting-Ting Zhang, Shi-Shuai Wen, Jun Xiang, Rong-Liang Shi, Guo-Hua Sun, Cai-Ping Huang, Yu Wang, Duan-Shu Li, Qing-Hai Ji, Qiang Shen

News

Coexistence of science and art—in celebration of Prof. Anthony Yim’s reception of PAMITS Honorary Fellowship

Brad Li

Surgical Technique

Extracorporeal radiation and reimplantation: a safe and viable option for reconstruction after sacral tumor resection?

Matthew L. Goodwin, Manit K. Gundavda, Rajeev Reddy, Kedar Deogaonkar, Murad Lala, Amresh Baliarsing, Daniel M. Sciubba, Kevin B. Jones, Manish Agarwal

Expert Consensus

Clinical practice guideline on traditional Chinese medicine therapy alone or combined with antibiotics for sepsis

Guo-Zhen Zhao, Ren-Bo Chen, Bo Li, Yu-Hong Guo, Yan-Ming Xie, Xing Liao, Yu-Fei Yang, Teng-Fei Chen, Hao-Ran Di, Fei Shao, Xiao-Qin Lv, Jing Hu, Shuo Feng, Qing-Quan Liu, Bo-Li Zhang