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ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

Focus on “Inborn Errors of Metabolism” edited by Dr. Shibani Kanungo and Dr. Dilip R. Patel

Annals of Translation Medicine (ATM) focused issue: inborn errors of metabolism (IEM) is a one stop resource for all levels of learners from undergraduates interested in science to multiple subspecialties in the field of medicine, genetics and public health.

Reading Companion: Blooming Flowers -A call for paper

Parent's Comments: Huilongwo was built in the Qing Dynasty. It is now a historic and cultural district in Xuzhou, in the center of the city. The old building in the painting is a corner of Huilongwo. Generally, children’s life experience lacks deeper nuances to understand the historical implications of architecture, in this painting, you can still see traces of tranquillity and vicissitudes. The usage of colors in this gives the old building vitality.

Focus on “Novel Aspects in Ventilator-associated Pneumonia” edited by Dr. Saad Nseir and Dr. Ignacio Martin-Loeches

Ventilator-associated pneumonia (VAP) remains an important clinical problem, being associated with significant morbidity and mortality. In this special issue of Annals of Translational Medicine, novel aspects regarding definition, diagnosis, epidemiology, and treatment of VAP are discussed by experts in this field.

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

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Vol 7, No 7 (April, 2019)

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Focused Issues more

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” More >>

Focus on “Inborn Errors of Metabolism” More >>

Focus on “Novel Aspects in Ventilator-associated Pneumonia” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

STAG2 loss-of-function mutation induces PD-L1 expression in U2OS cells

Zhirui Nie, Wenwen Gao, Yan Zhang, Yuhe Hou, Jingxian Liu, Zhaoqiang Li, Wei Xue, Xidong Ye, Anmin Jin

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AMBRA1-mediated autophagy and apoptosis associated with an epithelial-mesenchymal transition in the development of cleft palate induced by all-trans retinoic acid

Xuan Shu, Zejun Dong, Shenyou Shu

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Routine intensive monitoring but not routine intensive care unit-based management is necessary in video-assisted thoracoscopic surgery lobectomy for lung cancer

Seung Eun Lee, Woo Hyun Cho, Sang Kwon Lee, Ki Sup Byun, Bong Soo Son, Doosoo Jeon, Yun Seong Kim, Hye Ju Yeo

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Quality in practice: implementation of a clinical outcomes registry in regenerative medicine

Frank Zackary Jenio, Corey Scholes, Maimuna Marenah, Jinjie Li, Mac Cowley, Milad Ebrahimi, Meredith Harrison-Brown, William D. Murrell

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The effect of walnut rolling training on hand function and corticospinal tract

Sung Ho Jang, Tae Ho Kim, Han Do Lee

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Transplantation of dental tissue-derived mesenchymal stem cells ameliorates nephritis in lupus mice

Xiaojun Tang, Wenchao Li, Xin Wen, Zhuoya Zhang, Weiwei Chen, Genhong Yao, Hongwei Chen, Dandan Wang, Songtao Shi, Lingyun Sun

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Baseline serum lactate dehydrogenase level predicts survival benefit in patients with metastatic colorectal cancer receiving bevacizumab as first-line chemotherapy: a systematic review and meta-analysis of 7 studies and 1,219 patients

Wanjing Feng, Yue Wang, Xiaodong Zhu

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Enhancing autophagy protects platelets in immune thrombocytopenia patients

Chun-Yan Wang, Sai Ma, Shao-Jie Bi, Le Su, Shu-Ya Huang, Jun-Ying Miao, Chun-Hong Ma, Cheng-Jiang Gao, Ming Hou, Jun Peng

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Ability of serum procalcitonin to distinguish focus of infection and pathogen types in patients with bloodstream infection

Yinzhi Leng, Caiyun Chen, Yongxiang Zhang, Can Luo, Bo Liu

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Investigating the dysfunctional pathogenesis of Wilms’ tumor through a multidimensional integration strategy

Wenbiao Chen, Jia Zhuang, Lan Gong, Yong Dai, Hongyan Diao

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Deep learning based classification of ultrasound images for thyroid nodules: a large scale of pilot study

Qing Guan, Yunjun Wang, Jiajun Du, Yu Qin, Hongtao Lu, Jun Xiang, Fen Wang

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Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer

Yueyao Du, Liheng Zhou, Yanping Lin, Kai Yin, Wenjin Yin, Jinsong Lu

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Complete percutaneous laparoscopic cholecystectomy by employing the Percuvance Percutaneous Surgical System

Konstantinos Sapalidis, Athanasios Katsaounis, Stylianos Mantalovas, Christoforos Kosmidis, Ioannis Passos, Dimitrios Giannakidis, Efstathios Pavlidis, Nikolaos Michalopoulos, Charilaos Koulouris, Stelian Mogoanta, Valeriu Surlin, Aikaterini Amaniti, Paul Zarogoulidis, Isaak Kesisoglou

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Genomic alterations and survival in young patients aged under 40 years with completely resected non-small cell lung cancer

Shifeng Yang, Zhengbo Song, Guoping Cheng

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MicroRNA-200c-3p/ZEB2 loop plays a crucial role in the tumor progression of prostate carcinoma

Jiayi Zhang, Hengcheng Zhang, Yuan Qin, Chen Chen, Jie Yang, Ninghong Song, Min Gu

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M2 macrophages promote pulmonary endothelial cells regeneration in sepsis-induced acute lung injury

Yaxing Shen, Jieqiong Song, Yingqin Wang, Zhenglong Chen, Lin Zhang, Jie Yu, Duming Zhu, Ming Zhong

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Exploration of high-risk factors for pulmonary embolism in patients undergoing postoperative anti-thrombotic therapy among gynecologic oncology surgery: a retrospective study

Tongyu Liu, Shao-Wei Lin, Su Lin, Lin Yang, Haizhou Ji, Jianping Zou, Rong Xie

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Evaluation of the association between the −1304T>G polymorphism in the promoter of the MKK4 gene and the risk of colorectal cancer: a PRISMA-compliant meta-analysis

Rui Bai, Cheng Yuan, Fuxiang Zhou, Lihua Ni, Yan Gong, Conghua Xie

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Retrospective study of the interlaminar approach for percutaneous endoscopic lumbar discectomy with the guidance of pre-operative magnetic resonance neurography

Yanhong Liu, Shengtao Wang, Congxian Yang, Bo Zhong, Siyan Zhang, Jian Li, Zhijian Fu

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Clinical outcomes following long GnRHa ovarian stimulation with highly purified human menopausal gonadotropin plus rFSH or rFSH in patients undergoing in vitro fertilization-embryo transfer: a multi-center randomized controlled trial

Li Shu, Qianhua Xu, Qingxia Meng, Xue Dai, Yun Zhang, Wei Zhou, Honggang Yi, Jinyong Liu, Chunxiang Wu, Zhen Hou, Yugui Cui, Tin Chiu Li, Jiayin Liu

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Review Article

Anti-inflammatory therapy for cardiovascular disease

Constantine E. Kosmas, Delia Silverio, Andreas Sourlas, Peter D. Montan, Eliscer Guzman, Mario J. Garcia

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A paradigm shift in biomarker guided oncology drug development

Jan Trøst Jørgensen

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Case Report

Pulmonary metastases of fibrosarcomatous dermatofibrosarcoma protuberans respond to apatinib-based angiogenesis and chemotherapy: a case report

Huimin Chen, Yongmei Liu, Feng Peng, Juan Huang, Xiang Wen, Zhenyu Ding, Shouyue Zhang, Yan Zhang, You Lu

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Lipoblastoma of the left kidney: a case report and review of literature

Yangsheng Shi, Kang Yang, Man Zhang, Cheng Yi, Junfeng Yu

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Visualized Surgery

The application of selective neck dissection while preserving the cutaneous branches of cervical plexus in the surgical treatment of differentiated thyroid cancer—experiences from thousands of cases

Ning Qu, Ting-Ting Zhang, Shi-Shuai Wen, Jun Xiang, Rong-Liang Shi, Guo-Hua Sun, Cai-Ping Huang, Yu Wang, Duan-Shu Li, Qing-Hai Ji, Qiang Shen

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Big-data Clinical Trial Column

Predictive analytics with gradient boosting in clinical medicine

Zhongheng Zhang, Yiming Zhao, Aran Canes, Dan Steinberg, Olga Lyashevska, written on behalf of AME Big-Data Clinical Trial Collaborative Group

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Liver News Column

Obesity and acute-on-chronic liver failure

Andrew P. Keaveny

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Editorial Commentary

Surrogate endpoints in immunotherapy trials for solid tumors

Fausto Petrelli, Michele Ghidini, Antonio Costanzo, Valentina Rampulla, Antonio Varricchio, Gianluca Tomasello

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Coming of age of bevacizumab in the management of radiationinduced cerebral necrosis

Melvin L. K. Chua, Kevin L. M. Chua, Joseph T. S. Wee

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Discussion of a case report describing: total gastrectomy in an adult with intestinal malrotation

Jonathan Zadeh, Jessica Wahi, Kfir Ben-David

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Primary tumor size as a prognosticator in anal cancer patients

Pierfrancesco Franco, Umberto Ricardi

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Extracellular vesicles show promise for cancer theranostics

Meirav Segal, Frank J. Slack

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Biofilm and diabetic foot ulcer healing: all hat and no cattle

Lawrence A. Lavery, Kavitha Bhavan, Dane K. Wukich

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News

Coexistence of science and art—in celebration of Prof. Anthony Yim’s reception of PAMITS Honorary Fellowship

Brad Li

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Editorial for focused issue “Wilson Disease: From Genetics to Management of Disease”

Ralf Weiskirchen, Wolfgang Stremmel

Tumors of the spine and spinal cord

Matthew L. Goodwin, Daniel M. Sciubba

Editorial

Lactate as a key metabolic intermediate in cancer

L. Bruce Gladden

Review Article

Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma mass spectrometry

Sabine Weiskirchen, Philipp Kim, Ralf Weiskirchen

Wilson disease—treatment perspectives

Tomasz Litwin, Karolina Dzieżyc, Anna Członkowska

Clinical practice guidelines in Wilson disease

Chiara Saroli Palumbo, Michael L. Schilsky

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Cerebrospinal fluid leaks after spine tumor resection: avoidance, recognition and management

Sean M. Barber, Jared S. Fridley, Sanjay Konakondla, Jonathan Nakhla, Adetokunbo A. Oyelese, Albert E. Telfeian, Ziya L. Gokaslan

Systematic review on the utility of magnetic resonance imaging for operative management and follow-up for primary sarcoma—lessons from extremity sarcomas

Zach Pennington, A. Karim Ahmed, Ethan Cottrill, Erick M. Westbroek, Matthew L. Goodwin, Daniel M. Sciubba

Clinical features of Wilson disease

Wolfgang Stremmel, Uta Merle, Ralf Weiskirchen

Classification and differential diagnosis of Wilson’s disease

Wieland Hermann

Lactate and cancer: spinal metastases and potential therapeutic targets (part 2)

Zach Pennington, Matthew L. Goodwin, Erick M. Westbroek, Ethan Cottrill, A. Karim Ahmed, Daniel M. Sciubba

Total en bloc resection of primary and metastatic spine tumors

Elizabeth P. Howell, Theresa Williamson, Isaac Karikari, Muhammad Abd-El-Barr, Melissa Erickson, Matthew L. Goodwin, Jeremy Reynolds, Daniel M. Sciubba, C. Rory Goodwin

Clinical management of Wilson disease

Peter Hedera

Lactate and cancer: a “lactatic” perspective on spinal tumor metabolism (part 1)

Matthew L. Goodwin, Zach Pennington, Erick M. Westbroek, Ethan Cottrill, A. Karim Ahmed, Daniel M. Sciubba

Preclinical models of Wilson’s disease, why dogs are catchy alternatives

Hedwig S. Kruitwagen, Louis C. Penning

The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer

Udit Chaddha, D. Kyle Hogarth, Septimiu Murgu

Challenges in the diagnosis of Wilson disease

Aurélia Poujois, France Woimant

Current anti-copper therapies in management of Wilson disease

Isabelle Mohr, Karl Heinz Weiss

Liquid biopsy for lung cancers: an update on recent developments

Alberto E. Revelo, Alvaro Martin, Ricardo Velasquez, Prarthna Chandar Kulandaisamy, Jean Bustamante, Sevak Keshishyan, Gregory Otterson

Clinical manifestations of Wilson disease in organs other than the liver and brain

Karolina Dzieżyc-Jaworska, Tomasz Litwin, Anna Członkowska

New tools for Wilson’s disease diagnosis: exchangeable copper fraction

France Woimant, Nouzha Djebrani-Oussedik, Aurélia Poujois

Neurologic impairment in Wilson disease

Petr Dusek, Tomasz Litwin, Anna Członkowska

Placement of markers to assist minimally invasive resection of peripheral lung lesions

Ricardo Velasquez, Alvaro Martin, Mohammad Abu Hishmeh, Lawrence DeLorenzo, Samjot Singh Dhillon, Kassem Harris

Population screening and diagnostic strategies in screening family members of Wilson’s disease patients

Huamei Li, Ran Tao, Lifang Liu, Shiqiang Shang

Innovations in functional and rehabilitative knee bracing

Jim Hewlett, John Kenney

Diagnosis and management of peripheral lung nodule

Taha Khan, Yasir Usman, Tony Abdo, Fawad Chaudry, Jean I. Keddissi, Houssein A. Youness

Pros and cons of different ways to address dysfunctional autophagy in Pompe disease

Jeong-A Lim, Naresh Kumar Meena, Nina Raben

Anesthetic considerations for lung resection: preoperative assessment, intraoperative challenges and postoperative analgesia

Debra Lederman, Jasmeet Easwar, Joshua Feldman, Victoria Shapiro

Contemporary approach to the patient with malignant pleural effusion complicating lung cancer

Oleg Epelbaum, Najib M. Rahman

Molecular genetics of Pompe disease: a comprehensive overview

Paolo Peruzzo, Eleonora Pavan, Andrea Dardis

Original Article

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI

Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models

John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann

Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging

Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric K. Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael

Random forest can accurately predict the development of end-stage renal disease in immunoglobulin a nephropathy patients

Xin Han, Xiaonan Zheng, Ying Wang, Xiaoru Sun, Yi Xiao, Yi Tang, Wei Qin

Tumor location is an independent prognostic factor of esophageal adenocarcinoma based on the eighth edition of TNM staging system in Chinese patients

Han-Yu Deng, Xi Zheng, Guha Alai, Gang Li, Jun Luo, Ze-Guo Zhuo, Yi-Dan Lin

Intra- and interobserver reliability of the Spinal Instability Neoplastic Score system for instability in spine metastases: a systematic review and meta-analysis

Zach Pennington, A. Karim Ahmed, Ethan Cottrill, Erick M. Westbroek, Matthew L. Goodwin, Daniel M. Sciubba

Exploring the intraoperative lung protective ventilation of different positive end-expiratory pressure levels during abdominal laparoscopic surgery with Trendelenburg position

Yun Wang, Hong Wang, Huijuan Wang, Xiao Zhao, Shitong Li, Lianhua Chen

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Effect of chromatic contrast on stereoacuity measurement with computer-aided three-dimensional technology

Lingzhi Zhao, Huang Wu

The difference in stereoacuity testing: contour-based and random dot-based graphs at far and near distances

Lingzhi Zhao, Huang Wu

Obese patients have higher risk of breast cancer-related lymphedema than overweight patients after breast cancer: a meta-analysis

Ruxing Wu, Xiaoyuan Huang, Xiyuan Dong, Hanwang Zhang, Liang Zhuang

Ultrasound-guided preoperative single-dose erector spinae plane block provides comparable analgesia to thoracic paravertebral block following thoracotomy: a single center randomized controlled double-blind study

Bin Fang, Zhaomin Wang, Xiaojing Huang

SF3B1 mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients

Yi Miao, Yi-Xin Zou, Dan-Ling Gu, Hong-Cheng Zhu, Hua-Yuan Zhu, Li Wang, Jin-Hua Liang, Yi Xia, Jia-Zhu Wu, Chun-Lin Shao, Lei Fan, Zhen Zhang, Wei Xu, Jian-Yong Li

Clinical outcomes after absorbable suture fixation of patellar osteochondral fracture following patellar dislocation

Zu-Xi Li, Huang-He Song, Qing Wang, Dun-Ming Guo

Effects of sub-chronic, low-dose cadmium exposure on kidney damage and potential mechanisms

Qiling Liu, Rongqiang Zhang, Xiang Wang, Xiangli Shen, Peili Wang, Na Sun, Xiangwen Li, Xinhui Li, Chunxu Hai

The relationship between preliminary efficacy and prognosis after first-line EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment of advanced non-small cell lung cancer

Dongfang Chen, Tianqing Chu, Qing Chang, Yanwei Zhang, Liwen Xiong, Rong Qiao, Jiajun Teng, Baohui Han, Runbo Zhong

Astym^® therapy improves FOTO^® outcomes for patients with musculoskeletal disorders: an observational study

Leah S. Harris, Suzanne Freeman, Ying-Chih Wang

Long non-coding RNA IQCJ-SCHIP1 antisense RNA 1 is downregulated in colorectal cancer and inhibits cell proliferation

Jia Zhang, Zehua Bian, Guoying Jin, Yuhang Liu, Min Li, Surui Yao, Jing Zhao, Yuyang Feng, Xue Wang, Yuan Yin, Bojian Fei, Xiaofeng Han, Zhaohui Huang

Case Report

Management of presacral schwannomas—a 10-year multi-institutional series

Zach Pennington, Clemens Reinshagen, A. Karim Ahmed, Sean Barber, Matthew L. Goodwin, Ziya Gokaslan, Daniel M. Sciubba

Difficulties in diagnosis and treatment of Wilson disease—a case series of five patients

Anna Członkowska, Karolina Dzieżyc-Jaworska, Bożena Kłysz, Rędzia-Ogrodnik Barbara, Tomasz Litwin

First-line application of apatinib combined with S-1 based on peripheral circulating tumor cell screening to treat advanced gastric adenocarcinoma: a case report

Weikai Chen, Jianping Yu, Yanan Zhang, Wenjie Wang, Wenwen Yu, Xin Shi, Zipeng Xu, Hongbin Liu

Acute exacerbation of interstitial lung disease after radical surgery for lung cancer: a case report

Manni Zhu, Chaojie Wu, Zhenzhen Wu, Guangming Ren, Ningfei Ji, Mingshun Zhang, Mao Huang

The interesting case—orphan diseases—double trouble

Ulrike Reuner, Wolfgang Stremmel, Ralf Weiskirchen

Letter to the Editor

Is the Guytonian framework justified in explaining heart-lung interactions?

Rafael Dalmau

Positive correlation between telomere length and mitochondrial copy number in breast cancers

Won-Jin Park, Jae-Ho Lee

Venous return, mean systemic pressure and getting the right answer for the wrong reason

George L. Brengelmann

Surgical Technique

Extracorporeal radiation and reimplantation: a safe and viable option for reconstruction after sacral tumor resection?

Matthew L. Goodwin, Manit K. Gundavda, Rajeev Reddy, Kedar Deogaonkar, Murad Lala, Amresh Baliarsing, Daniel M. Sciubba, Kevin B. Jones, Manish Agarwal

Editorial Commentary

A deeper understanding of the tumor microenvironment in pancreatic cancer: the key to developing effective immunotherapies

Patrick W. Underwood, Jose G. Trevino

Is bilateral radiation an option for BRCA mutation carriers with unilateral breast cancer?

Steven A. Narod

Does alfacalcidol reduce cardiovascular complications in hemodialysis patients?

Louis-Charles Desbiens, Fabrice Mac-Way

Inflammatory lymphadenopathies predicting renal cell carcinoma prognosis: association not so convincing yet

Rizwan Ishtiaq, Zubair Khan

Which role for renal tumor ablation and which factors can influence long-term oncologic outcomes?

Roberto Iezzi, Riccardo Manfredi

VCAM-1+ macrophage subset as ‘educators’ in fetal liver for transition to definitive hematopoiesis

Pranela Rameshwar

Beyond the predictors of lymph node metastases in patients undergoing lymph node dissection for renal cell carcinoma: the impact of tumour side and location

Riccardo Campi, Francesco Sessa, Andrea Mari, Marco Carini, Sergio Serni, Andrea Minervini

Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke

Bernd Giebel, Dirk M. Hermann

Glucocorticoids: novel agents to stimulate beta-cell neogenesis?

Mark A. Russell, Pia Leete

Early-stage non-small cell lung cancer: the required type of resection (lobar vs. sublobar) remains unanswered

Natalie Baldes, Michael Eberlein, Servet Bölükbas

SELECTing adjuvant treatment in early stage epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer

Fabrizio Tabbò, Maria Lucia Reale, Enrico Ruffini, Silvia Novello, Francesco Guerrera

Metachronous renal cell carcinoma: An unbeatable leviathan?

Alessandro Antonelli, Alessandro Veccia, Riccardo Autorino

Inflammatory lymphadenopathy in renal cell carcinoma: prognostic tool?

Purnima Malhotra, Hemant Goel, Ashwani Kumar Mishra

Immunotherapy for head and neck cancer: where are we now and where are we going?

Joshua M. Bauml, Charu Aggarwal, Roger B. Cohen

Combining immunotherapy and epidermal growth factor receptor kinase inhibitors: worth the risk?

Hira Latif, Stephen V. Liu

Renal function after kidney surgery: “it’s tough to make predictions, especially about the future”

John M. DiBianco, Patrick T. Gomella, Mark W. Ball

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Depth of invasion for prognostic stratification in oral cavity cancer: do we need further validation?

Cesare Piazza, Lorenzo Bresciani, Lorenzo Giannini

Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products

Peter A. D. Wellham, Dong-Hyun Kim, Matthias Brock, Cornelia H. de Moor

Editorial commentary: the multiligament injured knee: current controversies and strategies for improving outcomes

Adnan Saithna

Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis

Xiaobo Zhu, Kaijia Zhang, Ke Lu, Tianshu Shi, Siyu Shen, Xingren Chen, Jian Dong, Wang Gong, Zhengyuan Bao, Yong Shi, Yuze Ma, Huajian Teng, Qing Jiang

Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

Quante Singleton, Santul Bapat, Sadanand Fulzele

Brain metastases in EGFR-positive non-small cell lung cancer: the way to the sanctuary becomes less winding

Antonio Passaro, Letizia Gianoncelli, Valeria Stati, Filippo de Marinis

Asymmetric dimethylarginine, erythropoietin resistance, and anemia in CKD

Tammy L. Sirich, Glenn M. Chertow

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.