About atm

Manuscript Submission

AME Editing Service

Reprint & Permission


Contact us

Focused Issues (Published) more

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” More >>
Focus on “Lower extremity arthroplasty” More >>
Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” More >>

Focused Issues (Ongoing) more

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge... More >>
Focused Issue on The Immature Spine More >>
Focused Issue on Stem Cell and Clinical Application More >>


Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Variable clinical features and genotype-phenotype correlations in 18 patients with late-onset Pompe disease
Jousef Alandy-dy, Marie Wencel, Kathy Hall, Julie Simon, Yanjun Chen, Erik Valenti, Jade Yang, Deeksha Bali, Anita Lakatos, Namita Goyal, Tahseen Mozaffar, Virginia Kimonis
Assessing metabolic profiles in human myoblasts from patients with late-onset Pompe disease
Peter Meinke, Sarah Limmer, Stefan Hintze, Benedikt Schoser

Review Article

Molecular genetics of Pompe disease: a comprehensive overview
Paolo Peruzzo, Eleonora Pavan, Andrea Dardis
Pros and cons of different ways to address dysfunctional autophagy in Pompe disease
Jeong-A Lim, Naresh Kumar Meena, Nina Raben
Restoring the regenerative balance in neuromuscular disorders: satellite cell activation as therapeutic target in Pompe disease
Gerben J. Schaaf, Rodrigo Canibano-Fraile, Tom J. M. van Gestel, Ans T. van der Ploeg, W. W. M. Pim Pijnappel
Newborn screening: Taiwanese experience
Yin-Hsiu Chien, Wuh-Liang Hwu, Ni-Chung Lee
Nutrition and exercise in Pompe disease
Mark A. Tarnopolsky, Mats I. Nilsson
Long-term outcome and unmet needs in infantile-onset Pompe disease
Andreas Hahn, Anne Schänzer
Multisystem late onset Pompe disease (LOPD): an update on clinical aspects
Antonio Toscano, Carmelo Rodolico, Olimpia Musumeci
Immunological challenges and approaches to immunomodulation in Pompe disease: a literature review
Ankit K. Desai, Cindy Li, Amy S. Rosenberg, Priya S. Kishnani
Diagnostic tools in late onset Pompe disease (LOPD)
Olimpia Musumeci, Antonio Toscano
Progress and challenges of gene therapy for Pompe disease
Giuseppe Ronzitti, Fanny Collaud, Pascal Laforet, Federico Mingozzi
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
An emerging phenotype of central nervous system involvement in Pompe disease: from bench to bedside and beyond
Aditi Korlimarla, Jeong-A Lim, Priya S. Kishnani, Baodong Sun
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Challenges in treating Pompe disease: an industry perspective
Hung V. Do, Richie Khanna, Russell Gotschall
Pompe disease: what are we missing?
Benedikt Schoser
The role of patient advocacy organizations in shaping medical research: the Pompe model
Tiffany House, Kevin O’Donnell, Raymond Saich, Fabio Di Pietro, Ria Broekgaarden, Allan Muir, Thomas Schaller


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Review Article

Original Article

Case Report

Letter to the Editor

Big-data Clinical Trial Column

Editorial Commentary