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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Diagnostic performance of C-reactive protein for parapneumonic pleural effusion: a meta-analysis
Dajiang Li, Yongchun Shen, Jiangyue Qin, Chun Wan, Ni Zeng, Lei Chen, Yue Dong
Histone deacetylase 6 selective inhibitor ACY1215 inhibits cell proliferation and enhances the chemotherapeutic effect of 5-fluorouracil in HCT116 cells
Yuyong Tan, Shilan Zhang, Hongyi Zhu, Yi Chu, Hejun Zhou, Deliang Liu, Jirong Huo
Can the echocardiographic LV mass equation reliably demonstrate stable LV mass following acute change in LV load?
Kavisha Patel, Nidhish Tiwari, Wilbert S. Aronow, Daniel Spevack
Who will benefit from thymectomy for myasthenia gravis? Is there any role for this procedure in elderly patients?
Ryo Otsuka, Kazuhiro Ueda, Toshiki Tanaka, Junichi Murakami, Masataro Hayashi, Kimikazu Hamano
The profile of patients receiving public and private surgical services in Greece during the economic crisis: a comparative study
Dimitrios Schizas, Adamantios Michalinos, Prodromos Kanavidis, Georgios Karaolanis, Irene Lidoriki, Athanasios D. Sioulas, Dimitrios Moris
Behavioral defects induced by chronic social defeat stress are protected by Momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT neuroinflammatory pathway
Zhifang Deng, Cheng Yuan, Jian Yang, Yan Peng, Wei Wang, Yan Wang, Wenqi Gao
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Evaluation of clinical risk factors for predicting insidious right central and posterior right recurrent laryngeal nerve lymph node metastasis in papillary thyroid microcarcinoma patients (cN0): experience of a single center
Fuqiang Li, Yijun Wu, Liang Chen, Liang Hu, Xiaosun Liu
Muscle weakness in a S. pneumoniae sepsis mouse model
Esther Witteveen, Luuk Wieske, Emmy Manders, Camiel Verhamme, Coen A. C. Ottenheijm, Marcus J. Schultz, Ivo N. van Schaik, Janneke Horn

Review Article

Interpretation and clinical practice of regulation for prevention and control of healthcare associated infection in outpatient and emergency department in healthcare facilities
Wen-Sen Chen, Fu Qiao, Yue Yang, Xiao-Dong Gao, Zhan-Jie Li, Yong-Xiang Zhang, Wei-Hong Zhang, Qiang Fu, Yun Liu

Column in Laboratory Medicine

Is digital epidemiology reliable?—insight from updated cancer statistics
Giuseppe Lippi, Gianfranco Cervellin

Big-data Clinical Trial Column

Balance diagnostics after propensity score matching
Zhongheng Zhang, Hwa Jung Kim, Guillaume Lonjon, Yibing Zhu, written on behalf of AME Big-Data Clinical Trial Collaborative Group


Vascular injuries during VATS lobectomies: keep calm, compress and have a plan
Luca Bertolaccini, Francesca Calabrese, Jury Brandolini, Piergiorgio Solli
Bleeding control during VATS major lung resection without conversion: safe and feasible?
Fabrizio Minervini, Peter Bruno Kestenholz, Luca Bertolaccini, Benedetta Bedetti, Davide Patrini, Enrico Cassina, Marco Scarci
What the future holds for the primary surgical repair as treatment of a massive pressure ulcer?
Aabid Sanaullah, Mohamed H. Ahmed
Trochanteric pressure ulcers: preoperative management and reconstructive considerations
Giulia Daneshgaran, Michael N. Cooper, Jaeyon Park, Christopher G. Pimentel, Alex K. Wong
How high is your conversion rate?—as high as necessary
Ralitsa Baranowski, David A. Waller
Is the video-assisted pulmonary segmentectomy the preferred approach to the early stage non-small cell lung cancer?
Alessandro Pardolesi, Luca Bertolaccini, Ugo Pastorino
Prevention is better than cure!
Mariagrazia Lorusso, Angela De Palma, Giulia De Iaco, Giuseppe Marulli
Refining thoracoscopic left S3 segmentectomy by a unidirectional approach
Wolfgang Jungraithmayr


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.



Review Article

Original Article

Case Report

Expert Consensus