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How does Wuhan respond to 2019-nCoV outbreak when the Spring Festival comes

According to the information released by Pepole’s Daily & DXY, (www.dxy.cn, the largest physician community in China), by 17:30 January 22, a total of 456 2019-nCoV cases had been reported in China, among which 25 were cured, and 9 died. The remaining patients had stable conditions and are isolated and treated in local designated hospitals.

Focused Issue on Gastroesophageal Cancer 2020

This Focused Issue on “Gastroesophageal Cancer 2020” is edited by Khaldoun Almhanna, MD, MPH, from Department of Hematology/Oncology, Lifespan Cancer Institute, Providence, RI, USA.

Focused Issue on Pain Therapy

This Focused Issue on “Pain Therapy” is edited by Dr. Antonio Ruggiero from Paediatric Oncology Unit, Department of Woman and Child Health, Agostino Gemelli Hospital, Catholic University of Rome, Largo Agostino Gemelli 8, 00168, Rome, Italy.

Focused Issue on Endovascular Interventions in Trauma

This Focused Issue on “Endovascular Interventions in Trauma” is edited by Dr. Keith Bertram Quencer from Division of Interventional Radiology, Department of Radiology, University of Utah, Salt Lake City, UT, USA.

Focused Issue on Ovarian Cancer: State of the Art and Perspectives of Clinical Research

This focused issue on Ovarian Cancer: State of the Art and Perspectives of Clinical Research is edited by Dr. Stergios Boussios, MD, MSc, PhD, MRCP, from Department of Medical Oncology, Medway NHS Foundation Trust, Kent, UK; and Dr. Nicholas Pavlidis, MD, PhD, FRCP, from University of Ioannina, Ioannina, Greece.

Focused Issue on Lung Emphysema

This focused issue on Lung Emphysema is edited by Dr. Bassam Redwan, MD, from Department of Thoracic Surgery, Klinikum Westfalen, Lünen, Germany.

Focused Issue on Lipid-Modifying Therapies Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

This Focused Issue on “Lipid-Modifying Therapies Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)” is edited by Dr. Constantine E. Kosmas, Director of Nuclear Cardiology and Lipid Clinic, Cardiology Unlimited, P.C., New York, NY, USA.

Focused Issue on Tumor Associated Macrophages in Solid Tumor: Friend or Foe

This focused issue on Tumor Associated Macrophages in Solid Tumor: Friend or Foe is edited by Dr. Gaurav Pandey, PhD, from Washington University School of Medicine, St. Louis, MO, USA.

Focused Issue on Current Trends and Advancements in Spine Surgery

In this focused issue of Annals of Translational Medicine, world-renowned leaders, academics, and physicians contribute their expertise and knowledge regarding the latest cutting-edge developments in the field of spine surgery. Trends discussed in this issue include the various ways in which the changing financial aspects and models of spine surgery are affecting the care delivered to patients.

Focused Issue on Cancer Metastasis: Molecular Signaling and Therapeutic

This Focused Issue on “Cancer Metastasis: Molecular Signaling and Therapeutic” is edited by Dr. Khalid Sossey-Alaoui, PhD, from Division of Cancer Biology, MetroHealth Medical Research Center, MetroHealth System, Cleveland, Ohio, USA.

ATM Annual Report 2019

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2020. 2019 has seen much progress for the journal:
- The first Impact Factor for ATM: 3.689
- More than 1000 papers have been published in ATM in 2019
- The retrieval of ATM in PubMed increased rapidly with a total of 2, 372, 977 times in 2019.
- The number of total citations by SCI journals has significantly increased to 11,592 until Dec. 2019
- The pageviews of ATM is increasing significantly, with a total of 1,034,942 hits in 2019.

ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

‹ ›

Vol 8, No 2 (January, 2020)

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Meet The Professor more

Professor Warren Boling: please be passionate about everything you do More >>

Professor Prithvi Mruthyunjaya: working together to move the field forward and better help our... More >>

Professor Seema Nagpal: which one should be given the priority, radiation or drug? More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Idiopathic scoliosis

Federico Canavese

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Review Article

The immature spine: growth and idiopathic scoliosis

Alain Dimeglio, Federico Canavese

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The impact of residual growth on deformity progression

Ismat Ghanem, Maroun Rizkallah

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Serial elongation derotation flexion casting in children with infantile and juvenile scoliosis

Federico Canavese, Alain Dimeglio

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Long term outcome of vertical expandable prosthetic titanium rib treatment in children with early onset scoliosis

Daniel Studer, Carol-Claudius Hasler

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Standard and magnetically controlled growing rods for the treatment of early onset scoliosis

Ilkka J. Helenius

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Spinal growth tethering: indications and limits

Peter O. Newton

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Adolescent idiopathic scoliosis: indications for bracing and conservative treatments

André J. Kaelin

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Frontal and sagittal imbalance in patients with adolescent idiopathic deformity

Ozren Kubat, Dror Ovadia

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Restoring sagittal and frontal balance following posterior instrumented fusion

Ozgur Dede, Muharrem Yazici

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Anterior instrumented fusion for adolescent idiopathic scoliosis

Michael Ruf, Jörg Drumm, Dezsö Jeszenszky

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Sublaminar polyester bands for the correction of idiopathic and neuromuscular scoliosis

Federico Canavese, Antoine Samba

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Strategies of management of deep spinal infection: from irrigation and debridement to vacuum-assisted closure treatment

Ismail Daldal, Alpaslan Senkoylu

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Scoliosis surgery in adulthood: what challenges for what outcome?

Yann Philippe Charles, Yves Ntilikina

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The importance of sagittal balance in adult scoliosis surgery

Jason Pui Yin Cheung

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Past, present, and future in pediatric spinal surgery

Jean Dubousset

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Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Rare paradoxical adverse event in Crohn’s disease: a case report

Marina Okoshi, Hiroki Sato, Terasu Honma, Shuji Terai

Editorial

A new peg-filgrastim biosimilar, mecapegfilgrastim for primary prophylaxis of chemotherapy-related neutropenia is now available

Umberto Tirelli, Antonino Carbone, Raffaele Di Francia, Massimiliano Berretta

TSPAN8 and distant metastasis of nasopharyngeal carcinoma cells

Changqing Xie, Nicole A. McGrath

Real-life clinical data mining: generating hypotheses for evidence-based medicine

Jean-Emmanuel Bibault

Joint forces for making clinical prediction models contribute to science

Junfeng Wang, Yue Li

Predictive analytics in the era of big data: opportunities and challenges

Zhongheng Zhang

Symptomatic late-onset hypogonadism but normal total testosterone: the importance of testosterone annual decrease velocity

Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Laura M. Mongioì, Ylenia Duca, Laura Cimino, Filippo Giacone, Antonio Aversa

Prolonged follow-up of colorectal cancer patients after 5 years: to follow or not to follow, that is the question (and how)!

Raul Caso, Anne Fabrizio, Michael Sosin

Minimally invasive mitral valve surgery to maximally benefit patients—what is the key to success today and tomorrow?

Moritz C. Wyler von Ballmoos

Clinical prediction model construction and evaluation: a challenge for clinical researchers

Qiu-Yan Han, Zhi-De Hu

Can transrectal ultrasound-guided core needle biopsy serve as an accurate diagnostic tool for rectal lesions?

Dong Hoon Baek, Gwang Ha Kim

Clinical prediction models: evaluation matters

Hong-Qiu Gu, Chelsea Liu

Combining old and new strategies for colorectal cancer screening

Elisa Danese, Martina Montagnana, Giuseppe Lippi

Overview of clinical prediction models

Lingxiao Chen

Mitochondrial solar sensitivity: evolutionary and biomedical implications

Andrei P. Sommer

Statistical methods and models in the analysis of time to event data

Minjung Lee, Junhee Han

Comparison between muscle-preserving selective laminectomy and laminoplasty for multilevel cervical spondylotic myelopathy

Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama

Maintaining anorectal function in patients with rectal cancer using biofeedback training

Andrea M. Stringer

Necessity of guidelines for publication of patient-derived cancer models

Tadashi Kondo

Can human placental extract help patients with osteoarthritis?

Nequesha S. Mohamed, Wayne A. Wilkie, Ethan A. Remily, Ronald E. Delanois

Mind body medicine: a tangible link between the gut and the brain

Luis Vitetta

Models and prediction, how and what?

Yujing Xie, Zhangsheng Yu

Targeting the mitogen-activated protein kinase-mediated vascular smooth muscle cell remodeling by angiotensin II

Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kiichi Nakahira

How to use statistical models and methods for clinical prediction

Giuliana Cortese

Editorial Commentary

Application of novel nanotechnologies in asthma

Adriana Lopes da Silva, Luisa Andrade Silva, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Marcelo Marcos Morales

Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage

Christina C. Kao, Amit D. Parulekar

Predicting fluid responsiveness with the passive leg raising test: don’t be fooled by intra-abdominal hypertension!

Andrea Minini, Paul Abraham, Manu L. N. G. Malbrain

The passive leg raising under pressure focus on the impact of intra-abdominal hypertension

Victor Beaucoté, Guillaume Geri, Antoine Vieillard-Baron

Periprocedural anticoagulation in non-ST-segment elevation acute coronary syndrome: time to reassess?

Rishi Chandiramani, Davide Cao, Roxana Mehran

Impact of renal impairment on light chain amyloidosis outcomes after autologous hematopoietic stem cell transplantation

Samer A. Srour, Muzaffar H. Qazilbash

Correlation between corticosteroid injections and surgical site infections in shoulder arthroscopy

Riccardo Compagnoni, Pietro Randelli

Unicompartmental knee arthroplasty over total knee arthroplasty: a more cost-effective strategy for treating medial compartment arthritis

Samuel W. Carlson, Rafael J. Sierra

Letter to the Editor

Von Hippel-Lindau: implications in development and disease—response

Kasey R. Cargill, Sunder Sims-Lucas

Platelet-derived HMGB1: critical mediator of SARs related to transfusion

Fabrice Cognasse, Caroline Sut, Hind Hamzeh-Cognasse, Olivier Garraud

Renal double negative T cells: increasing importance in health and disease

Mohanraj Sadasivam, Sanjeev Noel, Hamid Rabb, Abdel Rahim A. Hamad

Pan-cancer analysis of KEAP1 mutations as biomarkers for immunotherapy outcomes

Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou, Tao Jiang

Translating artificial intelligence into clinical practice

Duoru Lin, Haotian Lin

Below safety limits, every unit of glomerular filtration rate counts—reply letter

Carlotta Palumbo, Alessandro Antonelli

Cumulative antibiotic use significantly decreases efficacy of checkpoint inhibitors in patients with advanced cancer—reply to the editors

Nadina Tinsley, Donna M. Graham, Natalie Cook

A novel intrauterine stent for prevention of intrauterine adhesions

Huan Huang, Bin Xu, Chunxia Cheng, Dabao Xu

Why acute kidney injury during partial nephrectomy matters

Carlo A. Bravi, Andrew Vickers

Top-down proteomics—a near-future technique for clinical diagnosis?

Lidong He, Alan L. Rockwood, Archana M. Agarwal, Lissa C. Anderson, Chad R. Weisbrod, Christopher L. Hendrickson, Alan G. Marshall

ProBNP processing is decreased by obesity in patients with heart failure

Lynley K. Lewis, Sara D. Raudsepp, Tim C. R. Prickett, Tim G. Yandle, Chris J. Pemberton, A. Mark Richards

Prophylaxis of breast cancer chemotherapy for bone marrow toxicity: more individualized and safer

Fengrui Xu, Zefei Jiang

Meet the Professor

Prof. Leif Rogers: the recent advances in implant breast reconstruction and fat grafting

Karina Yang, Angelia Zhou

Prof. Helen Feltovich: today it’s 5G, tomorrow it’s 100G, who knows what can happen?

Jessie Bu, Angelia Zhou

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Net benefit of routine urine parameters for urinary tract infection screening: a decision curve analysis

Yan-Qiu Han, Lei Zhang, Jun-Rui Wang, Shang-Cheng Xu, Zhi-De Hu

An artificial intelligent platform for live cell identification and the detection of cross-contamination

Ruixin Wang, Dongni Wang, Dekai Kang, Xusen Guo, Chong Guo, Meimei Dongye, Yi Zhu, Chuan Chen, Xiayin Zhang, Erping Long, Xiaohang Wu, Zhenzhen Liu, Duoru Lin, Jinghui Wang, Kai Huang, Haotian Lin

Translational aspects of body image research for obesity-related quality of life and weight loss maintenance post-bariatric surgery

Marie L. Caltabiano

Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage

Dong Wei, Fei Gao, Zhenkun Yang, Wei Wang, Yinglun Chen, Yan Lu, Jingyu Chen

Can the preoperative nutritional risk score be a predictor of the outcomes in critically ill patients of lung transplantation: a retrospective study

Kongmiao Lu, Huixing Li, Yinglun Chen, Bo Wu, Ji Zhang, Man Huang, Jingyu Chen

Clinical outcomes of ceftazidime-avibactam in lung transplant recipients with infections caused by extensively drug-resistant gram-negative bacilli

Wenhui Chen, Lingxiao Sun, Lijuan Guo, Bin Cao, Yingmei Liu, Li Zhao, Binghuai Lu, Binbin Li, Jingyu Chen, Chen Wang

The value of high-resolution HLA in the perioperative period of non-sensitized lung transplant recipients

Ji Zhang, Dong Liu, Caixin Zhang, Min Zhou, Jian Lv, Hongmei Wang, Hang Yang, Li Fan, Bo Wu, Jingyu Chen

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry combined with UF-5000i urine flow cytometry to directly identify pathogens in clinical urine specimens within 1 hour

Chuang Sun, Xiao Zhang, Jingqiao Wang, Chen Cheng, Haiquan Kang, Bing Gu, Ping Ma

Logistic regression analyses of factors affecting fertility of intrauterine adhesions patients

Xingping Zhao, Yunzhi Liu, Aiqian Zhang, Bingsi Gao, Qing Feng, Huan Huang, Xiuting Zhu, Xin Sun, Dabao Xu

Obstetrical outcome in the third trimester after hysteroscopic adhesiolysis

Qing Feng, Bingsi Gao, Huan Huang, Jeffrey Je-Chuen Woo, Lingxiao Zou, Xingping Zhao, Chunxia Cheng, Dabao Xu

Study on the correlation among dysbacteriosis, imbalance of cytokine and the formation of intrauterine adhesion

Xingping Zhao, Qun Zhao, Xiuting Zhu, Huan Huang, Xing Wan, Rui Guo, Yanqiu Zhao, Dan Chen, Dabao Xu

Cold scissors ploughing technique in hysteroscopic adhesiolysis: a comparative study

Xingping Zhao, Aiqian Zhang, Bingsi Gao, Burjoo Arvind, Huan Huang, Dabao Xu

Building radiation-resistant model in triple-negative breast cancer to screen radioresistance-related molecular markers

Zhi-Rui Zhou, Xuan-Yi Wang, Xiao-Li Yu, Xin Mei, Xing-Xing Chen, Qun-Chao Hu, Zhao-Zhi Yang, Xiao-Mao Guo

Artificial intelligence-tutoring problem-based learning in ophthalmology clerkship

Dongxuan Wu, Yifan Xiang, Xiaohang Wu, Tongyong Yu, Xiucheng Huang, Yuxian Zou, Zhenzhen Liu, Haotian Lin

Automatic identification of myopia based on ocular appearance images using deep learning

Yahan Yang, Ruiyang Li, Duoru Lin, Xiayin Zhang, Wangting Li, Jinghui Wang, Chong Guo, Jianyin Li, Chuan Chen, Yi Zhu, Lanqin Zhao, Haotian Lin

The factors contributing to cognitive dysfunction in type 2 diabetic patients

San-Shan Xia, Wen-Lin Xia, Jiao-Jiao Huang, Hua-Jie Zou, Jing Tao, Yan Yang

Association between genetic risk scores and risk of narcolepsy: a case-control study

Hui Ouyang, Fang Han, Zechen Zhou, Qiwen Zheng, Yangyang Wang, Jun Zhang

Web-based study on Chinese dermatologists’ attitudes towards artificial intelligence

Changbing Shen, Chengxu Li, Feng Xu, Ziyi Wang, Xue Shen, Jing Gao, Randy Ko, Yan Jing, Xiaofeng Tang, Ruixing Yu, Junhu Guo, Feng Xu, Rusong Meng, Yong Cui

Growth hormone promotes human endometrial glandular cells proliferation and motion through the GHR-STAT3/5 pathway

Qing Feng, Bingsi Gao, Huan Huang, Lingxiao Zou, Xingping Zhao, Xiuting Zhu, Dabao Xu

Research of the potential biomarkers in vaginal microbiome for persistent high-risk human papillomavirus infection

Xiaopei Chao, Tingting Sun, Shu Wang, Xianjie Tan, Qingbo Fan, Honghui Shi, Lan Zhu, Jinghe Lang

Class A1 scavenger receptors mediated macrophages in impaired intestinal barrier of inflammatory bowel disease

Chenxi Xie, Yanyun Fan, Yinshi Huang, Shuangting Wu, Haimei Xu, Lupeng Liu, Yiqun Hu, Qingwen Huang, Huaxiu Shi, Lin Wang, Hongzhi Xu, Jingling Su, Jianlin Ren

The predictive value of baseline hepatic venous pressure gradient for variceal rebleeding in cirrhotic patients receiving secondary prevention

Chuan Liu, Yanna Liu, Ruoyang Shao, Sining Wang, Guangchuan Wang, Lifen Wang, Mingyan Zhang, Jinlin Hou, Chunqing Zhang, Xiaolong Qi

Prognosis and risk factors for the development of pulmonary metastases after preoperative chemoradiotherapy and radical resection in patients with locally advanced rectal cancer

Weihao Li, Jianhong Peng, Cong Li, Lifang Yuan, Wenhua Fan, Zhizhong Pan, Xiaojun Wu, Junzhong Lin

Initial anticoagulation experience with standard-dose rivaroxaban after Watchman left atrial appendage occlusion

Zhi-Chun Gu, Zhi-Qing Qiao, Zi-Yong Hao, Zheng Li, Li-Sheng Jiang, Heng Ge, Ben He, Jun Pu

Preoperative prediction of hepatocellular carcinoma with highly aggressive characteristics using quantitative parameters derived from hepatobiliary phase MR images

Zheng Ye, Likun Cao, Yi Wei, Jie Chen, Zhen Zhang, Shan Yao, Ting Duan, Bin Song

Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients

Xingqiang Lai, Zhongpeng Yao, Fen Ning, Lei Zhang, Jiali Fang, Guanghui Li, Lu Xu, Yunyi Xiong, Luhao Liu, Rongxin Chen, Junjie Ma, Zheng Chen

Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression

Wei He, Kaiming Yuan, Bin Ji, Yuan Han, Jun Li

Direct versus conventional anticoagulants for treatment of cancer associated thrombosis: a pooled and interaction analysis between observational studies and randomized clinical trials

Zhi-Chun Gu, Yi-Dan Yan, Sheng-Yan Yang, Long Shen, Ling-Cong Kong, Chi Zhang, An-Hua Wei, Zheng Li, Xin-Hua Wang, Hou-Wen Lin

Liver resection is beneficial for patients with colorectal liver metastases and extrahepatic disease

Kristina Hasselgren, Bengt Isaksson, Bjarne Ardnor, Gert Lindell, Magnus Rizell, Cecilia Strömberg, Per Loftås, Bergthor Björnsson, Per Sandström

Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits

Xiaohan Liu, Ying Hu, Lin Wu, Shujun Li

Establishing M1 stage subdivisions by incorporating radiological features and Epstein-Barr virus DNA for metastatic nasopharyngeal carcinoma

Wei-Hong Zheng, Xiao-Jun He, Fo-Ping Chen, Li Lin, Xiao-Dan Huang, Hua-Qiang Zhou, Jia Kou, Jia-Wei Lv, Jun Ma, Guan-Qun Zhou, Ying Sun

Scientometric analysis of mTOR signaling pathway in liver disease

Jing Fang, Long Pan, Qiu-Xia Gu, Sarun Juengpanich, Jun-Hao Zheng, Chen-Hao Tong, Zi-Yuan Wang, Jun-Jie Nan, Yi-Fan Wang

Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer

Shu-Biao Ye, Yi-Kan Cheng, Jian-Cong Hu, Feng Gao, Ping Lan

Surgical fixation of rib fractures decreases intensive care length of stay in flail chest patients

Xiangzhi Xiao, Shengchao Zhang, Juhua Yang, Jian Wang, Zhilong Zhang, Hao Chen

Three-dimensional printing flexible models: a novel technique for Nuss procedure planning of pectus excavatum repair

Lei Wang, Ting Guo, Hao Zhang, Sanhu Yang, Jiahe Liang, Yitong Guo, Qiuya Shao, Tiesheng Cao, Xiaofei Li, Lijun Huang

Review Article

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Bariatric surgery and gastroesophageal reflux disease

Darius Ashrafi, Emma Osland, Muhammed Ashraf Memon

Laparoscopic adjustable gastric banding, the past, the present and the future

Niccolò Furbetta, Rosa Cervelli, Francesco Furbetta

Impact of bariatric surgery on cancer risk reduction

Debora S. Bruno, Nathan A. Berger

Endoscopic intragastric balloon: a gimmick or a viable option for obesity?

Katja Susanne Claudia Gollisch, Dirk Raddatz

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

The diagnostic utility of pleural markers for tuberculosis pleural effusion

Man Zhang, Dan Li, Zhi-De Hu, Yuan-Lan Huang

China lung transplantation developing: past, present and future

Bo Wu, Chunxiao Hu, Wenhui Chen, Jianxing He, Gening Jiang, Ji Zhang, Dong Liu, Xiaoshan Li, Dong Wei, Guohui Jiao, Chen Wang, Jingyu Chen

Timing it right: the challenge of recipient selection for lung transplantation

Henry W. Ainge-Allen, Allan R. Glanville

Infection prophylaxis and management of viral infection

Emily S. Clausen, Lorenzo Zaffir

Using artificial intelligence to improve medical services in China

Ruiyang Li, Yahan Yang, Shaolong Wu, Kai Huang, Weirong Chen, Yizhi Liu, Haotian Lin

The combination of brain-computer interfaces and artificial intelligence: applications and challenges

Xiayin Zhang, Ziyue Ma, Huaijin Zheng, Tongkeng Li, Kexin Chen, Xun Wang, Chenting Liu, Linxi Xu, Xiaohang Wu, Duoru Lin, Haotian Lin

Advances in laboratory assays for detecting human metapneumovirus

Seri Jeong, Min-Jeong Park, Wonkeun Song, Hyon-Suk Kim

From the perspective of embryonic tendon development: various cells applied to tendon tissue engineering

Fangjie Qi, Zhantao Deng, Yuanchen Ma, Shuai Wang, Chang Liu, Fengjuan Lyu, Tao Wang, Qiujian Zheng

Diabetes and carotid artery disease: a narrative review

Niki Katsiki, Dimitri P. Mikhailidis

An update on chronic lung allograft dysfunction

Sakhee Kotecha, Miranda A. Paraskeva, Kovi Levin, Gregory I. Snell

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

iMDT Corner more

Pulmonary lesions associated with sputum culture-positive actinomycetes: report of one case

Pulmonary lesions associated with sputum culture-positive actinomycetes: report of one case More >>

Left destroyed lung caused by a pen cap in the left lower lobe bronchus “swallowed” 25 years ago

Left destroyed lung caused by a pen cap in the left lower lobe bronchus “swallowed” 25 years ago More >>

Conversion therapy from N3 unresectable lung adenocarcinoma to radical surgery: a case report

Huali Hu, Shuai Zou, Ruofu Xu, Yoshinobu Ichiki, Dirk De Ruysscher, Fenglei Yu, Aihui Liao More >>

Focused Issues (Published) more

This focused issue presents a collection of review articles on pediatric acute respiratory distress syndrome (PARDS). Despite a trend toward improved outcomes over the past decade or so, PARDS still leads to significant morbidities and mortality. This collection of review articles provides a comprehensive overview on this important disease in the pediatric critical care environment.

Focused Issue on Pediatric Acute Respiratory Distress Syndrome More >>