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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

Endorsement
Endorsement
Endorsement

the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

New insights in addressing endometrial dysfunction: the potential role of growth hormone
Sokratis Grigoriadis, Evangelos Maziotis, Nikolaos Vlahos, Mara Simopoulou
Mechanical ventilation during thoracic surgery: towards individualized medicine
Mauro Roberto Tucci, Sérgio Martins Pereira, Eduardo Leite Vieira Costa, Joaquim Edson Vieira
Cutting down on lung cancer: Ecliptasaponin A is a novel therapeutic agent
Mirja Rotinen, Ignacio Encío
Effects of primary hypertension treatment in the oncological outcomes of hepatocellular carcinoma
Victor Lopez-Lopez, Alvaro Gomez Ruiz, Asunción Lopez-Conesa, Roberto Brusadin, Valentin Cayuela, Albert Caballero-Illanes, Máximo Torres, Ricardo Robles Campos
Cunning maneuver regulating chemotherapy resistance in triple-negative breast cancer by eEF2K and autophagy
In Kyoung Lim
Point of care ultrasound: the next evolution of medical education
Ellen A. Gilbertson, Nathan D. Hatton, John J. Ryan
Use of 3D ultrasound in the hysteroscopic management of Asherman syndrome
Jose Carugno, Antonio Simone Laganà, Salvatore Giovanni Vitale
Hitting the brakes on autophagy for overcoming acquired resistance in triple negative breast cancer
Chiara Bellio, Josep Villanueva

Original Article

Children with SARS-CoV-2 infection during an epidemic in China (outside of Hubei province)
Feifan Xiao, Bin Chen, Tiantian Xiao, Shoo K. Lee, Kai Yan, Liyuan Hu
Profiles of intraocular higher-order aberrations in healthy phakic eyes: prospective cross-sectional study
Jiaqing Zhang, Guangming Jin, Ling Jin, Xiaoting Ruan, Xiaoxun Gu, Wei Wang, Xiaoyun Chen, Lanhua Wang, Ye Dai, Zhenzhen Liu, Lixia Luo, Yizhi Liu
RNF213 gene polymorphism rs9916351 and rs8074015 significantly associated with moyamoya disease in Chinese population
Bin Zhu, Xingju Liu, Xueke Zhen, Xixi Li, Mingfen Wu, Yan Zhang, Zhigang Zhao, Dong Zhang, Jizong Zhao
High-dose vitamin C alleviates pancreatic injury via the NRF2/NQO1/HO-1 pathway in a rat model of severe acute pancreatitis
Li-Li Xu, Bing Zhao, Si-Lei Sun, Si-Fei Yu, Yu-Ming Wang, Ran Ji, Zhi-Tao Yang, Li Ma, Yi Yao, Ying Chen, Hui-Qiu Sheng, Er-Zhen Chen, En-Qiang Mao
Adverse events associated with prophylactic corticosteroid use before extubation: a cohort study
Akira Kuriyama, Satoshi Egawa, Jun Kataoka, Masaaki Sakuraya, Masami Matsumura
DNA methylation status of imprinted H19 and KvDMR1 genes in human placentas after conception using assisted reproductive technology
Fengli Chi, Mei Zhao, Kunming Li, An-Qi Lin, Yingya Li, Xiaoming Teng
European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum biointact parathyroid hormone based on weekly samplings from 91 healthy participants
Michela Bottani, Giuseppe Banfi, Elena Guerra, Massimo Locatelli, Aasne K. Aarsand, Abdurrahman Coşkun, Jorge Díaz-Garzón, Pilar Fernandez-Calle, Sverre Sandberg, Ferruccio Ceriotti, Elisabet González-Lao, Margarita Simon, Anna Carobene, on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation
Cancer-associated fibroblasts enhance the chemoresistance of CD73+ hepatocellular carcinoma cancer cells via HGF-Met-ERK1/2 pathway
Hao Peng, Rong Xue, Zheng Ju, Jiannan Qiu, Jiawei Wang, Wei Yan, Xiaojie Gan, Yizhu Tian, Hongbin Shen, Xiaoming Wang, Xuehao Wang, Xuhao Ni, Yue Yu, Ling Lu
Comparison of a new anterior segment optical coherence tomography and Oculus Pentacam for measurement of anterior chamber depth and corneal thickness
Xuepei Li, Yijing Zhou, Charlotte Aimee Young, Aiming Chen, Guangming Jin, Danying Zheng
Artesunate exerts anti-prolactinoma activity by inhibiting mitochondrial metabolism and inducing apoptosis
Weiyu Zhang, Qiu Du, Piaopiao Bian, Zheng Xiao, Xin Wang, Yajuan Feng, Hou Feng, Ziyan Zhu, Nailin Gao, Diming Zhu, Xiang Fan, Yonghong Zhu
Machine learning-based CT radiomics method for predicting hospital stay in patients with pneumonia associated with SARS-CoV-2 infection: a multicenter study
Hongmei Yue, Qian Yu, Chuan Liu, Yifei Huang, Zicheng Jiang, Chuxiao Shao, Hongguang Zhang, Baoyi Ma, Yuancheng Wang, Guanghang Xie, Haijun Zhang, Xiaoguo Li, Ning Kang, Xiangpan Meng, Shan Huang, Dan Xu, Junqiang Lei, Huihong Huang, Jie Yang, Jiansong Ji, Hongqiu Pan, Shengqiang Zou, Shenghong Ju, Xiaolong Qi
Tumor mutation burden in Chinese cancer patients and the underlying driving pathways of high tumor mutation burden across different cancer types
Xiao-Dong Jiao, Xiao-Chun Zhang, Bao-Dong Qin, Dong Liu, Liang Liu, Jian-Jiao Ni, Zhou-Yu Ning, Ling-Xiang Chen, Liang-Jun Zhu, Song-Bing Qin, Shen-Peng Ying, Xue-Qin Chen, Ai-Jun Li, Ting Hou, Han Han-Zhang, Junyi Ye, Jingjing Zheng, Shannon Chuai, Yuan-Sheng Zang
Minimum local anesthetic dose of ropivacaine in real-time ultrasound-guided intraspinal anesthesia for lower extremity surgery: a randomized controlled trial
Ting Zheng, Peng Ye, Weilan Wu, Bin Hu, Lifei Chen, Xiaochun Zheng, Mingxue Lin
Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects
Dexter P. Mendoza, Puja Kohli, John W. Nance, Ramandeep Singh, Josalyn Cho, Jason Griffith, R. Scott Harris, Vanessa J. Kelly, Andrew D. Luster, Benjamin Medoff, Subba R. Digumarthy
The study of microtubule dynamics and stability at the postsynaptic density in a rat pilocarpine model of temporal lobe epilepsy
Xiaomei Wu, Ying Zhou, Zhiling Huang, Mingfei Cai, Yi Shu, Chang Zeng, Li Feng, Bo Xiao, Qiong Zhan
Methylation of the MAOA promoter is associated with schizophrenia
Hao Yang, Jiajue Li, Aicen Ji, Liping Hu, Xiufeng Zhang, Linlin Liu, Lili Qing, Ming Yan, Shengjie Nie
GLA missense and promoter variants co-segregating in a Chinese family with Fabry disease
Zhe-Yi Dong, Qian Wang, Shu-Peng Lin, Pu Chen, Jiao-Na Liu, Shu-Wen Liu, Guang-Yan Cai, Xiang-Mei Chen, Quan Hong
Immune-related genes play an important role in the prognosis of patients with testicular germ cell tumor
Chengjian Ji, Yichun Wang, Yi Wang, Jiaochen Luan, Liangyu Yao, Yamin Wang, Ninghong Song
Ex-vivo treatment of allografts using adipose-derived stem cells induced prolonged rejection-free survival in an allogenic hind-limb transplantation model
Yinmin Wang, Shoubao Wang, Chuan Gu, Yao Xiong, Hua Shen, Fei Liu, Jun Yang
Methylation-driven genes and their prognostic value in cervical squamous cell carcinoma
Jinhui Liu, Sipei Nie, Siyue Li, Huangyang Meng, Rui Sun, Jing Yang, Wenjun Cheng
Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner
Weizhe Zhong, Xiaowei Wang, Zhuqing Rao, Xiongxiong Pan, Yu Sun, Tao Jiang, Ping Wang, Haoming Zhou, Xuehao Wang
Gadoxetic acid-enhanced MRI radiomics signature: prediction of clinical outcome in hepatocellular carcinoma after surgical resection
Zhen Zhang, Jie Chen, Hanyu Jiang, Yi Wei, Xin Zhang, Likun Cao, Ting Duan, Zheng Ye, Shan Yao, Xuelin Pan, Bin Song
Comparison of the accuracy of intraocular lens power calculation formulas for eyes after corneal refractive surgery
Xiao-Zhen Wang, Rui Cui, Xu-Dong Song, Bo Yun, Jin Qian, Ning Ding
Optical coherence tomography-based deep learning algorithm for quantification of the location of the intraocular lens
Chen Xin, Gui-Bin Bian, Haojie Zhang, Weipeng Liu, Zhe Dong
Efficacy and safety of transcatheter aortic valve implantation in patients with severe bicuspid aortic stenosis
Bo Fu, Qingliang Chen, Feng Zhao, Zhigang Guo, Nan Jiang, Xu Wang, Wei Wang, Jiange Han, Li Yang, Yanbo Zhu, Yanhe Ma
Using a deep recurrent neural network with EEG signal to detect Parkinson’s disease
Shixiao Xu, Zhihua Wang, Jutao Sun, Zhiqiang Zhang, Zhaoyun Wu, Tiezhao Yang, Gang Xue, Chuance Cheng
Helicobacter pylori infection increases the risk of metabolic syndrome in pregnancy: a cohort study
Beilei Xia, Wenyuan Wang, Yufeng Lu, Chen Chen
LncRNA MACC1-AS1 attenuates microvascular endothelial cell injury and promotes angiogenesis under hypoxic conditions via modulating miR-6867-5p/TWIST1 in human brain microvascular endothelial cells
Guangjun Yan, Haomin Zhao, Xin Hong
Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling
Junli Zhang, Sen Li, Yuzhou Zhao, Pengfei Ma, Yanghui Cao, Chenyu Liu, Xijie Zhang, Wenpeng Wang, Li Chen, Yin Li
Pulmonary vascular enlargement on thoracic CT for diagnosis and differential diagnosis of COVID-19: a systematic review and meta-analysis
Haiying Lv, Tongtong Chen, Yaling Pan, Hanqi Wang, Liuping Chen, Yong Lu
Siderophores induce mitophagy-dependent apoptosis in platelets
Wenyuan Wang, Yufeng Lu, Yulin Wang, Yan Zhang, Beilei Xia, Juan Cao
Preparation of doxorubicin-loaded collagen-PAPBA nanoparticles and their anticancer efficacy in ovarian cancer
Haiyan Jiang, Guiwen Liang, Min Dai, Yansong Dong, Yao Wu, Luzhong Zhang, Qinghua Xi, Lei Qi
Tocilizumab exerts anti-inflammatory activity in six critically ill COVID-19 patients: a retrospective analysis
Shen Qian, Jianghong An, Furong Qi, Ling Ye, Qiong Chen, Xunqi Liu, Lixin Xie, Guobao Li
Quantitative CT measurement of left colonic and pelvic mesenteric adipose volume in radiation proctitis
Yonghua Cai, Tenghui Ma, Qinghua Zhong, Qiyuan Qin, Wuteng Cao, Zhanzhen Liu, Jia Ke, Hui Wang
The protective effect and mechanism of lentinan on acute kidney injury in septic rats
Xiaoping Li, Wanfen Zhang, Ping Li, Guoyuan Lu
Identification of critical genes in gastric cancer to predict prognosis using bioinformatics analysis methods
Jing Liu, Liang Ma, Zhiming Chen, Yao Song, Tinging Gu, Xianchen Liu, Hongyu Zhao, Ninghua Yao
Practice of prescription review mode based on data mining in hospital
Fan Xu, Jiayi Yin, Su Zeng
Medulloblastoma malignant biological behaviors are associated with HOTAIR/miR-483-3p/CDK4 axis
Long Zhao, Tao Chen, Xiaoping Tang, Shun Li, Ruofei Liang, Yuanchuan Wang

Case Report

Successful treatment of secondary macrophage activation syndrome with emapalumab in a patient with newly diagnosed adult-onset Still’s disease: case report and review of the literature
Jihad Ben Gabr, Eric Liu, Sundus Mian, Julie Pillittere, Eduardo Bonilla, Katalin Banki, Andras Perl
Double lung transplantation for Sjögren’s syndrome-related interstitial lung disease: a case report and review of literature
Yuqin Cao, Hailei Du, Jialin Liu, Hongping Qu, Yongjie Ding, Guochao Shi, Qing Xie, Xin Sun, Jingyu Chen, Shugao Ye, Junbiao Hang, Xiang Zhou, Yajie Zhang, Jules Lin, Jieming Qu, Hecheng Li
Hypoproteinemia being a manifestation of immunotherapy-related liver dysfunction
Juan Deng, Xiaoxia Chen, Hui Sun, Yu Liu, Wei Li, Bin Chen, Sha Zhao, Keyi Jia, Hao Wang, Haoyue Guo, Minlin Jiang, Yi Xu, Yayi He, Caicun Zhou
Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature
Zhitong Zuo, Haiyue Zhou, Yan Sun, Qing Mao, Yong Zhang, Xiaowei Gao

Review Article on Cancer Metastasis: Molecular Signaling and Therapeutic Options

Elucidating the molecular signaling pathways of WAVE3
Urna Kansakar, Wei Wang, Vesna Markovic, Khalid Sossey-Alaoui
Role of Kindlin-2 in cancer progression and metastasis
Wei Wang, Urna Kansakar, Vesna Markovic, Khalid Sossey-Alaoui
Invadopodia: clearing the way for cancer cell invasion
Katarzyna Augoff, Anita Hryniewicz-Jankowska, Renata Tabola
Epigenetic plasticity in metastatic dormancy: mechanisms and therapeutic implications
Nathaniel J. Robinson, Kimberly A. Parker, William P. Schiemann
Mitochondrial metabolism and cancer metastasis
Dandan Yu, Chang Liu, Ling Guo
Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity
Max Horowitz, Emily Esakov, Peter Rose, Ofer Reizes
Understanding breast cancer disparities—a multi-scale challenge
Hannah E. Hill, William P. Schiemann, Vinay Varadan
Novel targeted therapies for metastatic breast cancer
Khalid Jazieh, Ruth Bell, Nayan Agarwal, Jame Abraham

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review
He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng
Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report
Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng
Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma
Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside
Omran Abu Aboud, Robert H. Weiss
Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease
Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross
Dasatinib in breast cancer: Src-ing for response in all the wrong kinases
Laura C. Kennedy, Vijayakrishna Gadi
Cardiac troponin I—more than a biomarker for myocardial ischemia?
Li Ni, Xander H. T. Wehrens
Ifi204/p204, a new piece in the sepsis puzzle
Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay
Fusion heals the broken-hearted
Daniel A. Zuppo, Michael Tsang
Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?
Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?
Xu Han, Marvin T. Nieman
Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward
Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola
Surrogate end points in early prostate cancer clinical states: ready for implementation?
Christos E. Kyriakopoulos, Emmanuel S. Antonarakis
Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy
Theresa L. Whiteside
Evolving treatment options for valve and aortic disease with bicuspid aortic valve
Nicholas S. Burris, Michael D. Hope
Exosomes may play a crucial role in HIV dendritic cell immunotherapy
Benjamin Wolfson, Justine E. Yu, Qun Zhou
Custom cutting guides in total knee arthroplasty
Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont
Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Hong Tian, Wei Li
It takes time to tune
Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams
Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery
Ezekiel Maloney, Joo Ha Hwang
Re-assessing stem cells in the stomach—one story two tales
Ming Jiang, Jianwen Que
Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
Theresa L. Whiteside
One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence
Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Re-assessing the role of non-fasting lipids; a change in perspective
Zareen Farukhi, Samia Mora
Narcolepsy and influenza vaccination—the inappropriate awakening of immunity
Anoma Nellore, Troy D. Randall
A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases
Jonathan E. Phillips, Richard H. Gomer
Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy
Qiongling Wang, Xander H. T. Wehrens
The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy
Ziheng Xu, Daniel J. Klionsky
Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?
Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation
Austin John Barrett, Catherine M. Bollard
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights
Vibhu Parcha, Pankaj Arora
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment
Alex B. Blair, Vincent P. Groot, Jin He
Nephron repair: powered by anaerobic energy metabolism
Brooke E. Chambers, Rebecca A. Wingert
Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?
Andre P. Fay, Emmanuel S. Antonarakis
Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system
Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer
Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement
Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder
Melanie L. Bell
Low levels of interleukin-10 in patients with transfusion-related acute lung injury
Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple
Circulating CD40 autoantibody and suPAR synergy drives glomerular injury
Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser
Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs
Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis
Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu
Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders
Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro
Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora
Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study
Laurie J. Slovarp, Emma Bozarth
Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males
Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng
Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism
Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia
Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative
Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties
Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois
Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population
Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez
Prospective study of quality of life after lung cancer resection
Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur
Probiotics for prevention of urinary stones
John C. Lieske
Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia
Julie L. Mitchell, Thomas M. Yankee
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers
Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review
Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol
Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy
Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti
Liver depot gene therapy for Pompe disease
Priya S. Kishnani, Dwight D. Koeberl
Genetics and epigenetic factors of Wilson disease
Valentina Medici, Janine M. LaSalle
Ventilator-induced lung injury and lung mechanics
Jason H. T. Bates, Bradford J. Smith
Precision oncology in liver cancer
Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer
Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation
Tara R. Semenkovich, Bryan F. Meyers
Inhalation therapies in acute respiratory distress syndrome
Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay
The female urinary microbiota, urinary health and common urinary disorders
Linda Brubaker, Alan J. Wolfe
The association between bacteria and urinary stones
Andrew L. Schwaderer, Alan J. Wolfe
PDX1 associated therapy in translational medicine
Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi
Biomarkers of risk to develop lung cancer in the new screening era
Thomas Atwater, Pierre P. Massion
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease
Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques
Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging
William H. Bradford, Jeffrey H. Omens, Farah Sheikh
MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells
Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients
Ebrahim Afshinnekoo, Christopher E. Mason
Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors
Alexander D. Liddle
A sensible approach to targeting STAT3-mediated transcription
Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis
Circulating fibrocytes serve as a marker for clinical diagnosis
Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh
Collagen and fibronectin: threads linking obesity and breast cancer
Lesley G. Ellies
Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit
Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes
Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Andrew C. McKown, Lorraine B. Ware
TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis
Dragana Kopanja, Pradip Raychaudhuri
Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
Significance of microRNA-based biomarkers for pancreatic cancer
Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Health Service and Policy Research

Health Services & Policy Research in translational medicine
Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer
Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity
Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson
The real difficulty in improving concordance of clinical practice with guidelines
Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started
Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness
Hye-Min Jeon, Jeongwu Lee
Effective implementation of novel MET pharmacodynamic assays in translational studies
Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma
Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights
Michele Carbone, Haining Yang
Environmental asbestos exposure and risk of mesothelioma
Curtis W. Noonan

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease
Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage
Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics
Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation
Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy
Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report


Editorial


Editorial Commentary



Original Article

Ventricular arrhythmias in patients with functional mitral regurgitation and implantable cardiac devices: implications of mitral valve repair with Mitraclip®
Tomás Benito-González, Xavier Freixa, Cosmo Godino, Maurizio Taramasso, Rodrigo Estévez-Loureiro, Daniel Hernandez-Vaquero, Ana Serrador, Luis Nombela-Franco, David Grande-Prada, Ignacio Cruz-González, Rodolfo San Antonio, Michele Galasso, Mara Gavazzoni, Carmen Garrote, Antonio Portolés-Hernández, Pablo Avanzas, Felipe Fernández-Vázquez, Isaac Pascual

Review Article


Column in Laboratory Medicine


Erratum