Home - Annals of Translational Medicine

Tumor Associated Macrophages in Solid Tumor: Friend or Foe

The focused series aims to highlight the current status of TAMs research in context to solid tumors in a preclinical and clinical setting. We have invited distinguished scientists from the different onco- immunology field for this focused series. I hope, the reviews will help the reader to understand in detail macrophages topographical and temporal heterogeneity and functional diversity in different tumor types.

New Impact Factor for Annals of Translational Medicine: 3.297

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2019 citation year: 3.297.

Here, we would like to extend our heartfelt gratitude to all our Editorial Team Members, Guest Editors, authors, and reviewers for their significant contributions. We look forward to the continuous cooperation with all the individuals mentioned above and those who are interested in translational medicine to bring more exciting content to readers in the coming future. Read More>>

Cancer Metastasis: Molecular signaling and therapeutic options

As guest editor of this special series of the Annals of Translational Medicine (ATM), I would like to share with the readers at large the contributions from invited authors who provided their unique and expert perspectives on the important and critical topics of this focus series titled “Cancer Metastasis: Molecular signaling and therapeutic options”.

Medical Artificial Intelligent Research

The deep learning revolution and subsequent surge in the development of artificial intelligence (AI) didn’t take long to reach the world of medicine. In this special series on “Medical Artificial Intelligent Research”, we explore the latest developments through a collection of editorials, original articles, and reviews that set the stage for the challenges and opportunities in translating AI and related technologies into clinical practice.

Advances in Laboratory Tests for Infectious Diseases

In this special series of Annals of Translational Medicine, experienced clinicians, microbiologists, and laboratory technicians contribute some of their valuable works in the field of laboratory testing of infectious diseases.

Strategies to Achieve Long-Term Success of Lung Transplantation

To produce this series of Annals of Translational Medicine titled “Strategies to achieve long-term success of lung transplantation”, world experts in the field have generated comprehensive review articles in each specific area.

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others), as of April 2020. Around 60 AME journals’ peer review systems are now integrated seamlessly into the Publons platform (https://publons.com/about/home). The partnership was done to recognize our expert peer reviewers spontaneously for their review contribution.

Implementation of transparent peer review at Annals of Translational Medicine

With a commitment to openness and accountability, and to increase the level of transparency throughout our peer review process, our editorial office has decided to implement a transparent peer review process as an option for all manuscripts submitted to ATM from March 19, 2020.

ATM Annual Report 2019

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2020. 2019 has seen much progress for the journal:
- The first Impact Factor for ATM: 3.689
- More than 1000 papers have been published in ATM in 2019
- The retrieval of ATM in PubMed increased rapidly with a total of 2, 372, 977 times in 2019.
- The number of total citations by SCI journals has significantly increased to 11,592 until Dec. 2019
- The pageviews of ATM is increasing significantly, with a total of 1,034,942 hits in 2019.

Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions

Background: The coronavirus disease 2019 (COVID-19) outbreak originating in Wuhan, Hubei province, China, coincided with chunyun, the period of mass migration for the annual Spring Festival. To contain its spread, China adopted unprecedented nationwide interventions on January 23, 2020. These policies included large-scale quarantine, strict controls on travel and extensive monitoring of suspected cases. However, it is unknown whether these policies have had an impact on the epidemic. We sought to show how these control measures impacted the containment of the epidemic.

‹ ›

Vol 8, No 14 (July, 2020)

About atm

Manuscript Submission

AME Editing Service

Reprint & Permission

Advertising

Contact us

General editorial enquiries:
Email: editor@atmjournal.org
Copyright related contact:
Email: permissions@amegroups.com
Commercial Sales contact (Reprints, advertising, etc.):
Email: sales@amegroups.com

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

New insights in addressing endometrial dysfunction: the potential role of growth hormone

Sokratis Grigoriadis, Evangelos Maziotis, Nikolaos Vlahos, Mara Simopoulou

PDF Full Text COI Form Open Access

Mechanical ventilation during thoracic surgery: towards individualized medicine

Mauro Roberto Tucci, Sérgio Martins Pereira, Eduardo Leite Vieira Costa, Joaquim Edson Vieira

PDF Full Text COI Form Open Access

Cutting down on lung cancer: Ecliptasaponin A is a novel therapeutic agent

Mirja Rotinen, Ignacio Encío

PDF Full Text COI Form Open Access

Effects of primary hypertension treatment in the oncological outcomes of hepatocellular carcinoma

Victor Lopez-Lopez, Alvaro Gomez Ruiz, Asunción Lopez-Conesa, Roberto Brusadin, Valentin Cayuela, Albert Caballero-Illanes, Máximo Torres, Ricardo Robles Campos

PDF Full Text COI Form Open Access

Cunning maneuver regulating chemotherapy resistance in triple-negative breast cancer by eEF2K and autophagy

In Kyoung Lim

PDF Full Text COI Form Open Access

Point of care ultrasound: the next evolution of medical education

Ellen A. Gilbertson, Nathan D. Hatton, John J. Ryan

PDF Full Text COI Form Open Access

Use of 3D ultrasound in the hysteroscopic management of Asherman syndrome

Jose Carugno, Antonio Simone Laganà, Salvatore Giovanni Vitale

PDF Full Text COI Form Open Access

Hitting the brakes on autophagy for overcoming acquired resistance in triple negative breast cancer

Chiara Bellio, Josep Villanueva

PDF Full Text COI Form Open Access

Original Article

Children with SARS-CoV-2 infection during an epidemic in China (outside of Hubei province)

Feifan Xiao, Bin Chen, Tiantian Xiao, Shoo K. Lee, Kai Yan, Liyuan Hu

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Profiles of intraocular higher-order aberrations in healthy phakic eyes: prospective cross-sectional study

Jiaqing Zhang, Guangming Jin, Ling Jin, Xiaoting Ruan, Xiaoxun Gu, Wei Wang, Xiaoyun Chen, Lanhua Wang, Ye Dai, Zhenzhen Liu, Lixia Luo, Yizhi Liu

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

RNF213 gene polymorphism rs9916351 and rs8074015 significantly associated with moyamoya disease in Chinese population

Bin Zhu, Xingju Liu, Xueke Zhen, Xixi Li, Mingfen Wu, Yan Zhang, Zhigang Zhao, Dong Zhang, Jizong Zhao

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

High-dose vitamin C alleviates pancreatic injury via the NRF2/NQO1/HO-1 pathway in a rat model of severe acute pancreatitis

Li-Li Xu, Bing Zhao, Si-Lei Sun, Si-Fei Yu, Yu-Ming Wang, Ran Ji, Zhi-Tao Yang, Li Ma, Yi Yao, Ying Chen, Hui-Qiu Sheng, Er-Zhen Chen, En-Qiang Mao

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Adverse events associated with prophylactic corticosteroid use before extubation: a cohort study

Akira Kuriyama, Satoshi Egawa, Jun Kataoka, Masaaki Sakuraya, Masami Matsumura

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

DNA methylation status of imprinted H19 and KvDMR1 genes in human placentas after conception using assisted reproductive technology

Fengli Chi, Mei Zhao, Kunming Li, An-Qi Lin, Yingya Li, Xiaoming Teng

PDF Full Text Data Sharing Statement COI Form Open Access

European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum biointact parathyroid hormone based on weekly samplings from 91 healthy participants

Michela Bottani, Giuseppe Banfi, Elena Guerra, Massimo Locatelli, Aasne K. Aarsand, Abdurrahman Coşkun, Jorge Díaz-Garzón, Pilar Fernandez-Calle, Sverre Sandberg, Ferruccio Ceriotti, Elisabet González-Lao, Margarita Simon, Anna Carobene, on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine Working Group on Biological Variation

PDF Full Text Data Sharing Statement Peer Review File COI Form Open Access

Cancer-associated fibroblasts enhance the chemoresistance of CD73⁺ hepatocellular carcinoma cancer cells via HGF-Met-ERK1/2 pathway

Hao Peng, Rong Xue, Zheng Ju, Jiannan Qiu, Jiawei Wang, Wei Yan, Xiaojie Gan, Yizhu Tian, Hongbin Shen, Xiaoming Wang, Xuehao Wang, Xuhao Ni, Yue Yu, Ling Lu

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Comparison of a new anterior segment optical coherence tomography and Oculus Pentacam for measurement of anterior chamber depth and corneal thickness

Xuepei Li, Yijing Zhou, Charlotte Aimee Young, Aiming Chen, Guangming Jin, Danying Zheng

PDF Full Text Data Sharing Statement COI Form Open Access

Artesunate exerts anti-prolactinoma activity by inhibiting mitochondrial metabolism and inducing apoptosis

Weiyu Zhang, Qiu Du, Piaopiao Bian, Zheng Xiao, Xin Wang, Yajuan Feng, Hou Feng, Ziyan Zhu, Nailin Gao, Diming Zhu, Xiang Fan, Yonghong Zhu

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Machine learning-based CT radiomics method for predicting hospital stay in patients with pneumonia associated with SARS-CoV-2 infection: a multicenter study

Hongmei Yue, Qian Yu, Chuan Liu, Yifei Huang, Zicheng Jiang, Chuxiao Shao, Hongguang Zhang, Baoyi Ma, Yuancheng Wang, Guanghang Xie, Haijun Zhang, Xiaoguo Li, Ning Kang, Xiangpan Meng, Shan Huang, Dan Xu, Junqiang Lei, Huihong Huang, Jie Yang, Jiansong Ji, Hongqiu Pan, Shengqiang Zou, Shenghong Ju, Xiaolong Qi

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Tumor mutation burden in Chinese cancer patients and the underlying driving pathways of high tumor mutation burden across different cancer types

Xiao-Dong Jiao, Xiao-Chun Zhang, Bao-Dong Qin, Dong Liu, Liang Liu, Jian-Jiao Ni, Zhou-Yu Ning, Ling-Xiang Chen, Liang-Jun Zhu, Song-Bing Qin, Shen-Peng Ying, Xue-Qin Chen, Ai-Jun Li, Ting Hou, Han Han-Zhang, Junyi Ye, Jingjing Zheng, Shannon Chuai, Yuan-Sheng Zang

PDF Full Text Data Sharing Statement COI Form Open Access

Minimum local anesthetic dose of ropivacaine in real-time ultrasound-guided intraspinal anesthesia for lower extremity surgery: a randomized controlled trial

Ting Zheng, Peng Ye, Weilan Wu, Bin Hu, Lifei Chen, Xiaochun Zheng, Mingxue Lin

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects

Dexter P. Mendoza, Puja Kohli, John W. Nance, Ramandeep Singh, Josalyn Cho, Jason Griffith, R. Scott Harris, Vanessa J. Kelly, Andrew D. Luster, Benjamin Medoff, Subba R. Digumarthy

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

The study of microtubule dynamics and stability at the postsynaptic density in a rat pilocarpine model of temporal lobe epilepsy

Xiaomei Wu, Ying Zhou, Zhiling Huang, Mingfei Cai, Yi Shu, Chang Zeng, Li Feng, Bo Xiao, Qiong Zhan

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Methylation of the MAOA promoter is associated with schizophrenia

Hao Yang, Jiajue Li, Aicen Ji, Liping Hu, Xiufeng Zhang, Linlin Liu, Lili Qing, Ming Yan, Shengjie Nie

PDF Full Text Data Sharing Statement COI Form Open Access

GLA missense and promoter variants co-segregating in a Chinese family with Fabry disease

Zhe-Yi Dong, Qian Wang, Shu-Peng Lin, Pu Chen, Jiao-Na Liu, Shu-Wen Liu, Guang-Yan Cai, Xiang-Mei Chen, Quan Hong

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Immune-related genes play an important role in the prognosis of patients with testicular germ cell tumor

Chengjian Ji, Yichun Wang, Yi Wang, Jiaochen Luan, Liangyu Yao, Yamin Wang, Ninghong Song

PDF Full Text Reporting Checklist COI Form Open Access

Ex-vivo treatment of allografts using adipose-derived stem cells induced prolonged rejection-free survival in an allogenic hind-limb transplantation model

Yinmin Wang, Shoubao Wang, Chuan Gu, Yao Xiong, Hua Shen, Fei Liu, Jun Yang

PDF Full Text Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Methylation-driven genes and their prognostic value in cervical squamous cell carcinoma

Jinhui Liu, Sipei Nie, Siyue Li, Huangyang Meng, Rui Sun, Jing Yang, Wenjun Cheng

PDF Full Text Peer Review File COI Form Open Access

Aging aggravated liver ischemia and reperfusion injury by promoting hepatocyte necroptosis in an endoplasmic reticulum stress-dependent manner

Weizhe Zhong, Xiaowei Wang, Zhuqing Rao, Xiongxiong Pan, Yu Sun, Tao Jiang, Ping Wang, Haoming Zhou, Xuehao Wang

PDF Full Text Data Sharing Statement COI Form Open Access

Gadoxetic acid-enhanced MRI radiomics signature: prediction of clinical outcome in hepatocellular carcinoma after surgical resection

Zhen Zhang, Jie Chen, Hanyu Jiang, Yi Wei, Xin Zhang, Likun Cao, Ting Duan, Zheng Ye, Shan Yao, Xuelin Pan, Bin Song

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Comparison of the accuracy of intraocular lens power calculation formulas for eyes after corneal refractive surgery

Xiao-Zhen Wang, Rui Cui, Xu-Dong Song, Bo Yun, Jin Qian, Ning Ding

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Optical coherence tomography-based deep learning algorithm for quantification of the location of the intraocular lens

Chen Xin, Gui-Bin Bian, Haojie Zhang, Weipeng Liu, Zhe Dong

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Efficacy and safety of transcatheter aortic valve implantation in patients with severe bicuspid aortic stenosis

Bo Fu, Qingliang Chen, Feng Zhao, Zhigang Guo, Nan Jiang, Xu Wang, Wei Wang, Jiange Han, Li Yang, Yanbo Zhu, Yanhe Ma

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Using a deep recurrent neural network with EEG signal to detect Parkinson’s disease

Shixiao Xu, Zhihua Wang, Jutao Sun, Zhiqiang Zhang, Zhaoyun Wu, Tiezhao Yang, Gang Xue, Chuance Cheng

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Helicobacter pylori infection increases the risk of metabolic syndrome in pregnancy: a cohort study

Beilei Xia, Wenyuan Wang, Yufeng Lu, Chen Chen

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

LncRNA MACC1-AS1 attenuates microvascular endothelial cell injury and promotes angiogenesis under hypoxic conditions via modulating miR-6867-5p/TWIST1 in human brain microvascular endothelial cells

Guangjun Yan, Haomin Zhao, Xin Hong

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling

Junli Zhang, Sen Li, Yuzhou Zhao, Pengfei Ma, Yanghui Cao, Chenyu Liu, Xijie Zhang, Wenpeng Wang, Li Chen, Yin Li

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Pulmonary vascular enlargement on thoracic CT for diagnosis and differential diagnosis of COVID-19: a systematic review and meta-analysis

Haiying Lv, Tongtong Chen, Yaling Pan, Hanqi Wang, Liuping Chen, Yong Lu

PDF Full Text Reporting Checklist COI Form Open Access

Siderophores induce mitophagy-dependent apoptosis in platelets

Wenyuan Wang, Yufeng Lu, Yulin Wang, Yan Zhang, Beilei Xia, Juan Cao

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Preparation of doxorubicin-loaded collagen-PAPBA nanoparticles and their anticancer efficacy in ovarian cancer

Haiyan Jiang, Guiwen Liang, Min Dai, Yansong Dong, Yao Wu, Luzhong Zhang, Qinghua Xi, Lei Qi

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Tocilizumab exerts anti-inflammatory activity in six critically ill COVID-19 patients: a retrospective analysis

Shen Qian, Jianghong An, Furong Qi, Ling Ye, Qiong Chen, Xunqi Liu, Lixin Xie, Guobao Li

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Quantitative CT measurement of left colonic and pelvic mesenteric adipose volume in radiation proctitis

Yonghua Cai, Tenghui Ma, Qinghua Zhong, Qiyuan Qin, Wuteng Cao, Zhanzhen Liu, Jia Ke, Hui Wang

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

The protective effect and mechanism of lentinan on acute kidney injury in septic rats

Xiaoping Li, Wanfen Zhang, Ping Li, Guoyuan Lu

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Identification of critical genes in gastric cancer to predict prognosis using bioinformatics analysis methods

Jing Liu, Liang Ma, Zhiming Chen, Yao Song, Tinging Gu, Xianchen Liu, Hongyu Zhao, Ninghua Yao

PDF Full Text Reporting Checklist COI Form Open Access

Practice of prescription review mode based on data mining in hospital

Fan Xu, Jiayi Yin, Su Zeng

PDF Full Text Data Sharing Statement COI Form Open Access

Medulloblastoma malignant biological behaviors are associated with HOTAIR/miR-483-3p/CDK4 axis

Long Zhao, Tao Chen, Xiaoping Tang, Shun Li, Ruofei Liang, Yuanchuan Wang

PDF Full Text Reporting Checklist Data Sharing Statement COI Form Open Access

Case Report

Successful treatment of secondary macrophage activation syndrome with emapalumab in a patient with newly diagnosed adult-onset Still’s disease: case report and review of the literature

Jihad Ben Gabr, Eric Liu, Sundus Mian, Julie Pillittere, Eduardo Bonilla, Katalin Banki, Andras Perl

PDF Full Text COI Form Reporting Checklist Open Access

Double lung transplantation for Sjögren’s syndrome-related interstitial lung disease: a case report and review of literature

Yuqin Cao, Hailei Du, Jialin Liu, Hongping Qu, Yongjie Ding, Guochao Shi, Qing Xie, Xin Sun, Jingyu Chen, Shugao Ye, Junbiao Hang, Xiang Zhou, Yajie Zhang, Jules Lin, Jieming Qu, Hecheng Li

PDF Full Text Reporting Checklist COI Form Open Access

Hypoproteinemia being a manifestation of immunotherapy-related liver dysfunction

Juan Deng, Xiaoxia Chen, Hui Sun, Yu Liu, Wei Li, Bin Chen, Sha Zhao, Keyi Jia, Hao Wang, Haoyue Guo, Minlin Jiang, Yi Xu, Yayi He, Caicun Zhou

PDF Full Text Reporting Checklist COI Form Open Access

Rapidly growing solitary fibrous tumors of the pleura: a case report and review of the literature

Zhitong Zuo, Haiyue Zhou, Yan Sun, Qing Mao, Yong Zhang, Xiaowei Gao

PDF Full Text Reporting Checklist COI Form Open Access

Editorial Commentary

Radiotherapy target volume for limited-disease small cell lung cancer: good news from the dark side of the moon

Branislav Jeremic, Ivane Kiladze, Marta Jeremic, Nenad Filipovic

PDF Full Text COI Form Open Access

Opicinumab: is it a potential treatment for multiple sclerosis?

Zubair Ahmed, Daniel Fulton, Michael R. Douglas

PDF Full Text COI Form Open Access

Looking for a better measure of the benefit in clinical trials: a never-ending journey

Gennaro Daniele, Diana Giannarelli, Emilio Bria

PDF Full Text COI Form Open Access

Biomarkers of response to immune checkpoint inhibitors for metastatic castration resistant prostate cancer: looking for the needle in the haystack

Husam A. Alqaisi, Esmail Al-ezzi, Aaron R. Hansen

PDF Full Text COI Form Open Access

Cancer treatment at the end of life in older patients

Stuart M. Lichtman

PDF Full Text COI Form Open Access

Malignant pleural mesothelioma: between pragmatism and hope

Marcello Migliore

PDF Full Text COI Form Open Access

Understanding sex differences in progression and prognosis of chronic kidney disease

Andrea G. Kattah, Vesna D. Garovic

PDF Full Text COI Form Open Access

Is AJCC 8^th Edition useful in qualifying melanoma patients to adjuvant therapy?

Jacek Mackiewicz, Andrzej Mackiewicz

PDF Full Text Open Access

Editorial on Cancer Metastasis: Molecular Signaling and Therapeutic Options

Perspectives on molecular signaling in cancer and update on therapeutic options for the treatment of metastatic cancer

Khalid Sossey-Alaoui

PDF Full Text COI Form Open Access

Review Article on Cancer Metastasis: Molecular Signaling and Therapeutic Options

Elucidating the molecular signaling pathways of WAVE3

Urna Kansakar, Wei Wang, Vesna Markovic, Khalid Sossey-Alaoui

PDF Full Text COI Form Open Access

Role of Kindlin-2 in cancer progression and metastasis

Wei Wang, Urna Kansakar, Vesna Markovic, Khalid Sossey-Alaoui

PDF Full Text COI Form Open Access

Invadopodia: clearing the way for cancer cell invasion

Katarzyna Augoff, Anita Hryniewicz-Jankowska, Renata Tabola

PDF Full Text COI Form Open Access

Epigenetic plasticity in metastatic dormancy: mechanisms and therapeutic implications

Nathaniel J. Robinson, Kimberly A. Parker, William P. Schiemann

PDF Full Text COI Form Open Access

Mitochondrial metabolism and cancer metastasis

Dandan Yu, Chang Liu, Ling Guo

PDF Full Text COI Form Open Access

Signaling within the epithelial ovarian cancer tumor microenvironment: the challenge of tumor heterogeneity

Max Horowitz, Emily Esakov, Peter Rose, Ofer Reizes

PDF Full Text COI Form Open Access

Understanding breast cancer disparities—a multi-scale challenge

Hannah E. Hill, William P. Schiemann, Vinay Varadan

PDF Full Text COI Form Open Access

Novel targeted therapies for metastatic breast cancer

Khalid Jazieh, Ruth Bell, Nayan Agarwal, Jame Abraham

PDF Full Text COI Form Open Access

Erratum

Erratum to renal progenitor cells modulated by angiotensin II receptor blocker (ARB) medication and differentiation towards podocytes in anti-thy1.1 nephritis

Di Wu, Jiuxu Bai, Shaoyuan Cui, Bo Fu, Zhiwei Yin, Guangyan Cai, Xiangmei Chen

PDF Full Text Open Access

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Extralobar pulmonary sequestration with a cyst: a case report

Jian Li, Yingmei Jiang, Jiarong Xiao, Guiyou Liang

Hyperprogressive disease in advanced cancer patients with liver metastasis treated with PD-1 inhibitors: two case reports

Zhuangbin Lin, Qing Liu, Qiongyin Wei, Lan Lin, Xiangqi Chen, Dan Xue

Editorial

Combination surgery for hepatocellular carcinoma: slashing and burning to improved survival

John C. McVey, Kazunari Sasaki

Limitations of the Barcelona clinic liver cancer staging treatment strategy in hepatocellular carcinoma patients with performance status 1

Jung Hwan Yu, Jin-Woo Lee

Hysteroscopic removal of retained products of conception: historic approach or new iteration?

Usha Verma, Frank A. Crespo

Whether immediate frozen-thawed embryo transfer improves IVF outcome in non-elective freeze all policy

Loris Marin, Amerigo Vitagliano

Changes in prognostic factors for patients with hepatocellular carcinoma underwent transarterial chemoembolization with the transition of the time: Child-Pugh class, Albumin-Bilirubin grade, and then

Takumi Kawaguchi, Shigeo Shimose, Sakura Yamamura, Dan Nakano, Masatoshi Tanaka, Takuji Torimura

Prevention and treatment of strokes associated with carotid artery stenosis: a research priority

Kosmas I. Paraskevas

Tumor-associated macrophages in solid tumor: friend or foe

Gaurav Pandey

Infective endocarditis in the 21th century

Francesco Nappi, Cristiano Spadaccio, Christos Mihos

Traumatic macular holes: to operate, or not to operate, that is the question

Aristomenis Thanos, Bozho Todorich

Elective frozen embryo transfer (freeze-all): there seems to be no harm to transfer in the next immediate menstrual cycle

Matheus Roque, Sandro C. Esteves

Role of inflammatory indices in management of hepatocellular carcinoma—neutrophil to lymphocyte ratio

Vishal G. Shelat

Exploring new pathways in the treatment of hepatocellular cancer

Łukasz Masior, Michał Grąt

Clinical efficacy of liver resection combined with adjuvant microwave coagulation for patients with hepatocellular carcinoma: a promising approach to minimize recurrence?

Emanuele Felli, Zineb Cherkaoui, Patrick Pessaux

Correlation between cancer stem cells (CSCs) and tumor- infiltrating lymphocytes (TILs): do TILs interact with CSCs in non- small cell lung cancer?

Min Ling, Xiaolong Yang

Can lactate dehydrogenase (LDH) be used as a marker of severity of pneumonia in patients with renal transplant?

Carlos M. Luna, María M. Perín

Critical care echocardiography: diagnostic or prognostic?

Philippe Vignon

Child Pugh and ALBI grade: past, present or future?

Margherita Rimini, Giulia Rovesti, Andrea Casadei-Gardini

Animal models closer to intrauterine adhesive pathology

Sung Woo Kim, Yoon Young Kim, Hoon Kim, Seung-Yup Ku

Editorial to the OCT Angiography in Glaucoma series

Gábor Holló

EFCC1 as a putative prognostic biomarker in lung adenocarcinoma

Shengnan Yu, Gao Zhang

Early renal replacement therapy in acute kidney injury: a piece in the puzzle

Alexandre Braga Libório, Candice Torres de Melo Bezerra Cavalcante

Multinomial and ordinal Logistic regression analyses with multi-categorical variables using R

Jiaqi Liang, Guoshu Bi, Cheng Zhan

Neutrophil-to-lymphocyte ratio as a prognostic biomarker in hepatocellular carcinoma after transarterial chemoembolization

Soung Won Jeong

Implications of the COVID-19 pandemic on orthopaedic surgical residency and fellowship training: lost opportunity or novel experience?

Morad Chughtai, Anas A. Minkara, Thomas E. Kuivila, Brendan M. Patterson

Emerging multi-modal diagnostic approaches for moyamoya disease

Jae W. Song, Zhaoyang Fan

FAPα in pancreatic stellate cells upregulated by TGFβ1: a novel insight into pancreatic cancer progress

Yonggan Xue, Georg Beyer, Julia Mayerle

The interplay between miR-1245a and BRCA2 in colorectal cancer

Andreas Scorilas, Konstantina Panoutsopoulou, Panagiotis Tsiakanikas

Preemptive renal replacement therapy in critically ill patients?

Melanie Meersch, Alexander Zarbock

Protecting the lungs but hurting the kidneys: causal inference study for the risk of ventilation-induced kidney injury in ARDS

Haopu Yang, Panayiotis V. Benos, Georgios D. Kitsios

The role of prolyl oligopeptidase, understanding the puzzle

J. Arturo García-Horsman

Foxk1 regulates cancer progression

Daniel J. Garry, Geunho Maeng, Mary G. Garry

Predictive scores for hepatocellular carcinoma: a race with no winners?

Raffaella Tortora, Marco Guarracino, Giovan Giuseppe Di Costanzo

Structural heart disease: the revolution

Daniel Hernandez-Vaquero

HPV in non-oropharyngeal head and neck cancer: does it matter?

Nicole C. Schmitt

COVID-19 is shifting the adoption of wearable monitoring and telemedicine (WearTel) in the delivery of healthcare: opinion piece

Ralph J. Mobbs, Daniel Ho, Wen Jie Choy, Callum Betteridge, Henry Lin

Editorial Commentary

To sling or not to sling the shoulder after rotator cuff repair: which side are you on?

In-Ho Jeon, Erica Kholinne

Past, current and future management of secondary mitral valve disease: the importance of anatomic staging

Daniel H. Drake, Karen G. Zimmerman, David A. Sidebotham

Checkpoint inhibitors in primary mediastinal B-cell lymphoma: a step forward in refractory/relapsing patients?

Monica Balzarotti, Armando Santoro

Comment on a recent genetic study on the risk profile of Hirschsprung’s disease from a pediatric surgeon’s perspective

Nana Nakazawa-Tanaka, Geoffrey J. Lane, Atsuyuki Yamataka

Immune checkpoint inhibitor in liver cancer—unique regional differences

Shuntaro Obi, Takahisa Sato, Shinpei Sato

The adjuvant regimen for resected EGFR mutated patients: the “same-for-all-therapy” or not?

Cesare Gridelli, Francesca Casaluce

Tivozanib for hepatocellular carcinoma: not likely a new option

Florian Estrade, Fanny Le Du, Laurence Crouzet, Héloïse Bourien, Léa Muzellec, Julien Edeline

Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease

Anirudh R. Gone, Wei Chen

Tenascin-C: an emerging prognostic biomarker in diabetes

Saori Yonebayashi, Kazuko Tajiri, Siqi Li, Akira Sato

A novel classification for local recurrence after surgical removal of renal cell cancer

Takeshi Yuasa

Editorial Commentary: Tivozanib versus sorafenib in patients with advanced renal cell carcinoma (TIVO-3): a phase 3, multicentre, randomised, controlled, open-label study

Mary E. Westerman, Christopher G. Wood

Adjuvant EGFR TKIs in NSCLC harboring EGFR mutations: looking for a consensus way

Ilaria Attili, Antonio Passaro, Lorenzo Spaggiari, Gianluca Spitaleri, Filippo de Marinis

Pembrolizumab (and friends) in pediatric malignancies: should we consider Hodgkin lymphoma a world of its own?

Mattia Algeri, Franco Locatelli

Proton stereotactic body radiation therapy for non-small cell lung cancer

Tejan Diwanji, Amit Sawant, Terence T. Sio, Nirav V. Patel, Pranshu Mohindra

Perifissural nodules: ready for application into lung cancer CT screening?

Anton Schreuder, Cornelia M. Schaefer-Prokop

Transbronchial cryobiopsy for diffuse parenchymal lung diseases: evidence that demands a (favorable) verdict

Matthew Aboudara, Fabien Maldonado

New evidence for liver venous deprivation: safety and feasibility for extended liver resections

Jiang Zhang, Christian J. Steib

IMPassionate about immunotherapy for TNBC: from change, to revolution and to cure?

Elena Vagia, Massimo Cristofanilli

Macrophage depletion: a potential immunomodulator treatment of endometriosis-associated pain?

Thomas M. D’Hooghe, Arne Vanhie, Valerie A. Flores, Hugh S. Taylor

Cigarette smoking and lung function decline beyond quitting

Jennifer L. Perret, E. Haydn Walters

The role of c-MET inhibitors in advanced hepatocellular carcinoma: now and future

Hyun Young Woo, Jeong Heo

Multikinase inhibitors to treat hepatocellular carcinoma failures to sorafenib—time has come for a better approach

Saleh A. Alqahtani, Massimo Colombo

Keynote-158 study, FDA granted accelerated approval of pembrolizumab for the treatment of patients with advanced PD-L1-positive cervical cancer

Edith Borcoman, Christophe Le Tourneau

Combination therapy of transcatheter arterial chemoembolization with axitinib for the treatment of inoperable hepatocellular carcinoma

Kazuhiro Nouso, Akiko Wakuta, Kazuya Kariyama

Antibiotic stewardship in critically ill patients with suspected ventilator-associated pneumonia

Jumpei Yoshimura, Hideki Hashimoto, Kazuma Yamakawa

A large randomized clinical trial is necessary to establish the role of camrelizumab in hepatocellular carcinoma

Nishal Ravindran, Paul J. Thuluvath

The LncRNA, the phosphatase, and the macrophage: can they team up for support in inflammatory diseases?

Marcel Kuhny, Michael Huber

Transarterial chemoembolization (TACE) plus sorafenib: a real winning combination?

Xavier Adhoute, Rodolphe Anty, Marc Bourlière

Paving the way to precision medicine for diabetic kidney disease: the PRIORITY trial

Meir Schechter, Gil Leibowitz, Ofri Mosenzon

Romosozumab, clinical trials, and real-world care of patients with osteoporosis

E. Michael Lewiecki

More is not always better—what can be learned from the D-CARE trial

Georg Pfeiler, Michael Gnant

Socioeconomic gradient in health: mind the gap in ‘invisible’ disparities

Marialaura Bonaccio, Augusto Di Castelnuovo, Giovanni de Gaetano, Licia Iacoviello

Hard truths about preoperative knee X-rays

Wai-Keong Mak, Hamid Rahmatullah Bin Abd Razak

Dose matters for stereotactic body radiotherapy for early stage non-small cell lung cancer

Christian C. Okoye, C. Jane Cho, Mitchell Liu, Alexander V. Louie, Olusola Obayomi-Davies, Shankar Siva, Simon S. Lo

Veverimer: an advance in base therapy for metabolic acidosis

Clayton Brady, Elie R. Chemaly, James W. Lohr, Mark D. Parker

Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) versus chemotherapy in luminal B early breast cancer: lessons from the CORALLEEN trial

Claudia De Angelis, Michail Ignatiadis, Martine Piccart-Gebhart

It is time to prepare for D-CARE!

Christoph Suppan, Marija Balic

Innate immune checkpoints for cancer immunotherapy: expanding the scope of non T cell targets

Luis F. Campesato, Chien-Huan Weng, Taha Merghoub

Endothelial growth factor receptor-mutant lung cancer and post-operative care management: one size does not fit all

Javeryah Safi, Sarah W. Gordon, Peter Lee, Howard Li, Patrick Nana-Sinkam, Rachit D. Shah, Ray W. Shepherd, Samira Shojaee

Radiotherapy tumor volume for limited-stage small cell lung cancer: less is more

Antonin Levy, Corinne Faivre-Finn

Importance of genotyping patients for HLA-C*06:02: it provides not only pharmacogenetics implication in response to biologics drugs but also drug survival and drug-related costs information

Marina Talamonti, Marco Galluzzo

MET immunochemistry: a reliable screening tool for MET exon 14 skipping mutations in non-small cell lung cancer?

Melinda A. Pruis, Jan H. von der Thüsen, Hendrikus Jan Dubbink

Tivozanib in advanced inoperable hepatocellular carcinoma: considerations for patients with liver cirrhosis

Hyunwoo Oh, Jeong-Hoon Lee

Home spirometry to assess efficacy of pirfenidone in progressive unclassifiable interstitial lung disease: better the devil you know than the devil you don’t

Giacomo Sgalla, Pier-Valerio Mari, Luca Richeldi

How to quantify monoclonal free light chains in plasma cell disorders: which mass spectrometry technology?

Caroline Moreau, Charles R. Lefevre, Olivier Decaux

Different perspectives and viewpoints on the postoperative management of EGFR-mutant lung cancer

Masayuki Nakao, Junji Ichinose, Yosuke Matsuura, Sakae Okumura, Mingyon Mun

EGFR and non-small cell lung cancer: implications for surgical practice

Gonzalo Varela, Nuria M. Novoa

Transbronchial cryobiopsy in the diagnosis of interstitial lung diseases: methodologies and perspectives from the Cryo-PID and COLDICE studies

Carey Suehs, Arnaud Bourdin, Isabelle Vachier, Nicolas Molinari, Micaela Romagnoli

Time to stop using hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma?—the SCOOP-2 trial experience

Markus Peck-Radosavljevic, Simona Bota, Florian Hucke

Distinct metabolic preference of atypical KRAS mutant

Heesun Cheong

Translating KEYNOTE-048 into practice recommendations for head and neck cancer

Petr Szturz, Jan B. Vermorken

New solutions to old problems—metabolic acidosis in chronic kidney disease

John Sy, Joline L. T. Chen, Kamyar Kalantar-Zadeh

A biologically effective dose threshold for stereotactic body radiation therapy—can we put the issue to BED?

Michael Mix, Jeffrey A. Bogart

Angiogenesis inhibitors for advanced hepatocellular carcinoma: in search for the right partner

Claudia Campani, Lorenza Rimassa, Nicola Personeni, Fabio Marra

Exenatide at mealtimes in type 1 diabetes—no MAG1C with exenatide, or with other glucagon-like peptide-1 receptor agonists

Sheila A. Doggrell

Devil in the detail: MET overexpression fails as surrogate marker for MET exon 14 splice site mutations in NSCLC

Matthew R. Strickland, Pasi A. Jänne

Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma—targeting a novel PD-1 epitope to treat hepatocellular carcinoma

Yannick Sebastiaan Rakké, Dave Sprengers, Jaap Kwekkeboom, Jan Nicolaas Maria IJzermans

Percutaneous liver biopsy: another option of hepatic sample collection approach in single-cell sequencing studies?

Zi-Yuan Zou, Jian-Gao Fan

Oncogene addiction and immune escape: friends or foes?

Pamela Abdayem, David Planchard

Of fungi and men: role of fungi in pancreatic cancer carcinogenesis

Heling Wang, Mjriam Capula, Bastiaan P. Krom, Dicky Yee, Elisa Giovannetti, Dongmei Deng

Why aren’t we getting consistent results for heart dose and mortality during thoracic radiotherapy?

Jianxin Xue, You Lu, Feng-Ming (Spring) Kong

Lenvatinib in elderly hepatocellular carcinoma patients, a new therapeutic option in first line

Gael S. Roth, Bleuenn Brusset, Thomas Decaens

VENUSS rising for papillary renal cell carcinoma prognostication?

Tomas Buchler

Caring about bone-modifying agents (BMAs) in women with early-stage breast cancer

Charles L. Shapiro

Oncolytic immunotherapy for metastatic cancer: lessons and future strategies

Zong-Sheng Guo

Dose escalation in the era of ablative lung irradiation: is more dose better when it comes to delivery of lung stereotactic body radiation therapy?

Fiori Alite, Anand Mahadevan

Towards a tailored systemic therapy for liver cancer

Rodolfo Sacco, Antonio Facciorusso

Adjuvant treatment with EGFR TKI in resected non-small cell lung cancer with EGFR mutation: all that glitters is not gold!

Alfonso Fiorelli, Fabiana Vitiello, Floriana Morgillo, Rosa Maria Di Crescenzo, Andrea Bianco, Mario Santini, Marina Di Domenico

Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?

Charlotte K. Boughton, Roman Hovorka

Diagnosis in interstitial lung disease: highly confident histopathological results from transbronchial cryobiopsy are reliable

Lars Hagmeyer, Sandhya Matthes, Konrad Frank, Winfried Randerath

Prognostic models in papillary renal cell carcinoma

Kyrollis Attalla, Martin H. Voss, A Ari Hakimi

Combined locoregional and systemic therapy for advanced hepatocellular carcinoma: finally, the future is obscure

Khashayar Farsad, Nima Nabavizadeh, Adel Kardosh, Janice H. Jou, Willscott E. Naugler, Kenneth J. Kolbeck

Optimizing adjuvant therapy in EGFR-mutated non-small cell lung cancer

Annemarie F. Shepherd, Isabel R. Preeshagul, Narek Shaverdian, Abraham J. Wu, Daphna Y. Gelblum, Daniel R. Gomez, Andreas Rimner, Charles B. Simone II

Safety and preliminary signs of efficacy with the combination of pembrolizumab plus oxaliplatin and S-1 in Japanese gastric cancer patients

Maria Alsina, Elizabeth C. Smyth

Letter to the Editor

Keeping pace with the world: improving the clinical practice of anti-NMDAR encephalitis in China

Hongzhi Guan

Significance of long-term surveillance for branch-duct intraductal papillary mucinous neoplasms from the perspective of molecular pathological epidemiology

Keisuke Kosumi, Hiromitsu Hayashi, Hideo Baba

Original Article

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Extracellular ubiquitin promotes hepatoma metastasis by mediating M2 macrophage polarization via the activation of the CXCR4/ERK signaling pathway

Jiajing Cai, Qi Zhang, Xuemeng Qian, Jingdong Li, Qi Qi, Ru Sun, Jia Han, Xinfang Zhu, Mengyi Xie, Xiaolan Guo, Rong Xia

Anatomical femoral tunnel positioning in the medial patellofemoral ligament reconstruction: is the free-hand technique accurate?

Guilherme Moreira de Abreu-e-Silva, Felipe Antônio Ruy Buarque, Thiago Scherr Dias, Pengfei Lei, Elton Luis Ribeiro Bueno, Marco Antônio Percope de Andrade

Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer

Xiangmei Zhang, Jingping Li, Qing Yang, Yanfang Wang, Xinhui Li, Yunjiang Liu, Baoen Shan

Determinants of intraocular lens tilt and decentration after cataract surgery

Xiaoxun Gu, Xiaoyun Chen, Guangyao Yang, Wei Wang, Wei Xiao, Guangming Jin, Lanhua Wang, Ye Dai, Xiaoting Ruan, Zhenzhen Liu, Lixia Luo, Yizhi Liu

Hepatobiliary phase hypointensity on gadobenate dimeglumine- enhanced magnetic resonance imaging may improve the diagnosis of hepatocellular carcinoma

Yueming Li, Jianwei Chen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Liting Wen, Dairong Cao, Jinsheng Hong

Functional mitral regurgitation: structural modifications with percutaneous valve repair with MitraClip

Alberto Alperi, Pablo Avanzas, Isaac Pascual, Antonio Adeba, Rebeca Lorca, Victor León, Marcel Almendarez, Hector Cubero-Gallego, Iria Silva-Conde, César Moris, Daniel Hernandez-Vaquero

Evaluation of the updated “Candida score” with Sepsis 3.0 criteria in critically ill patients

Dongkai Li, Jiahui Zhang, Wen Han, Guangxu Bai, Wei Cheng, Na Cui

Pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement

Xu-Tao Chen, Rong-Hai Deng, Shi-Cong Yang, Xiao-Tao Hou, Jun Li, Yan-Yang Chen, Hui-Fei Yang, Ze-Yuan Wang, Chang-Xi Wang, Jiang Qiu, Li-Zhong Chen, Wen-Fang Chen, Gang Huang

Genetic alterations in cfDNA of benign and malignant thyroid nodules based on amplicon-based next-generation sequencing

Siting Cao, Shuang Yu, Yali Yin, Lei Su, Shubin Hong, Yingying Gong, Weiming Lv, Yanbing Li, Haipeng Xiao

Interaction between common variants of MDM2 and PPP1R13L and CD3EAP and TP53 SNPs in relation to lung cancer risk among Chinese

Jiaoyang Yin, Wei Hou, Ulla Vogel, Yegang Ma, Chunhong Wang, Huiwen Wang, Zhenxiang Sun

Ventricular arrhythmias in patients with functional mitral regurgitation and implantable cardiac devices: implications of mitral valve repair with Mitraclip^®

Tomás Benito-González, Xavier Freixa, Cosmo Godino, Maurizio Taramasso, Rodrigo Estévez-Loureiro, Daniel Hernandez-Vaquero, Ana Serrador, Luis Nombela-Franco, David Grande-Prada, Ignacio Cruz-González, Rodolfo San Antonio, Michele Galasso, Mara Gavazzoni, Carmen Garrote, Antonio Portolés-Hernández, Pablo Avanzas, Felipe Fernández-Vázquez, Isaac Pascual

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Developmental characteristics of the cytokine profile in aqueous humor and its relationship with the inflammatory response in children

Weiyi Lai, Xiaohang Wu, Dongni Wang, Zhenzhen Liu, Duoru Lin, Lanqin Zhao, Weirong Chen, Haotian Lin, Yizhi Liu

Quantitative analysis of multiphase magnetic resonance images may assist prediction of histopathological grade of small hepatocellular carcinoma

Shuping Weng, Xuru Xu, Yueming Li, Chuan Yan, Jianwei Chen, Rongping Ye, Yuemin Zhu, Liting Wen, Jinsheng Hong

Development and validation of a four-microRNA signature for placenta accreta spectrum: an integrated competing endogenous RNA network analysis

Tian Yang, Na Li, Rui Hou, Chong Qiao, Caixia Liu

Real-world data on the effectiveness and safety of interferon-alpha-2a intralesional injection for the treatment of focally recalcitrant mycosis fungoides

Shi-Yu Zhang, Zhao-Rui Liu, Lu Yang, Tao Wang, Jie Liu, Yue-Hua Liu, Kai Fang

Temporal changes of COVID-19 pneumonia by mass evaluation using CT: a retrospective multi-center study

Chao Wang, Peiyu Huang, Lihua Wang, Zhujing Shen, Bin Lin, Qiyuan Wang, Tongtong Zhao, Hanpeng Zheng, Wenbin Ji, Yuantong Gao, Junli Xia, Jianmin Cheng, Jianbing Ma, Jun Liu, Yongqiang Liu, Miaoguang Su, Guixiang Ruan, Jiner Shu, Dawei Ren, Zhenhua Zhao, Weigen Yao, Yunjun Yang, Bo Liu, Minming Zhang

Impact of the number of examined lymph nodes on stage migration in node-negative gastric cancer patients: a Chinese multi-institutional analysis with propensity score matching

Pengfei Gu, Jingyu Deng, Wei Wang, Zhenning Wang, Zhiwei Zhou, Huimian Xu, Han Liang

Long term follow up of percutaneous treatment for degenerated Mitroflow prosthesis with self-expanding transcatheter aortic valve implantation

Isaac Pascual, Marcel Almendárez, Rut Álvarez Velasco, Antonio Adeba, Daniel Hernández-Vaquero, Rebeca Lorca, Rocío Díaz, Alberto Alperi, Héctor Cubero-Gallego, Jose Rozado, César Morís, Pablo Avanzas

Dissociation between airway and systemic autoantibody responses in chronic obstructive pulmonary disease

Zhenyu Liang, Fei Long, Kuimiao Deng, Fengyan Wang, Jing Xiao, Yuqiong Yang, Dongying Zhang, Weili Gu, Jiaxuan Xu, Wenhua Jian, Weijuan Shi, Jinping Zheng, Xin Chen, Yang Gao, Qun Luo, Martin R. Stampfli, Tao Peng, Rongchang Chen

Coronavirus disease 2019: MRI examination procedures and infection prevention and protection

Xiaoyong Shen, Jinwen Meng, Qidong Wang, Lingmei Ni, Zifeng Zhong, Shaohua Hu, Feng Chen

Blocking the Notch signal transduction pathway promotes tumor growth in osteosarcoma by affecting polarization of TAM to M2 phenotype

Shuguang Ren, Xiangmei Zhang, Yueyang Hu, Jianhua Wu, Yingchao Ju, Xu Sun, Yunjiang Liu, Baoen Shan

Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer and promotes the proliferation of colon cancer cells

Mengke Niu, Ming Yi, Bing Dong, Suxia Luo, Kongming Wu

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Effect of cataract surgery on quality of life for patients with severe vision impairment due to age-related macular degeneration

Claudia Taipale, Andrzej Grzybowski, Raimo Tuuminen

The efficacy and complications of computed tomography guided microwave ablation in lung cancer

Bin Chen, Wei Li, Yu Liu, Shengxiang Ren, Lei Wang, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He, Caicun Zhou

The combination of forskolin and VPA increases gene expression efficiency to the hypoxia/neuron-specific system

Zhimin Pan, Jinsoo Oh, Lu Huang, Zhaoxun Zeng, Pingguo Duan, Zhiyun Li, Yeomin Yun, Janghwan Kim, Yoon Ha, Kai Cao

Comparison of iPTH and calcium levels between total thyroidectomy and lobectomy: a prospective study of 840 thyroid cancers with three years of follow-up

Xiaoli Liu, Xuehai Bian, Changlin Li, Jingwei Xin, Qingfeng Fu, Chunhai Zhang, Fang Li, Jinxi Jiang, Gianlorenzo Dionigi, Hui Sun

Identification of hub genes in diabetic kidney disease via multiple-microarray analysis

Yumin Zhang, Wei Li, Yunting Zhou

Percutaneous treatment with Mitraclip for functional mitral regurgitation: medium-term follow up according to left ventricular function

Isaac Pascual, Tomás Benito-González, Daniel Hernandez-Vaquero, Rodrigo Estévez-Loureiro, Rebeca Lorca, Carmen Garrote-Coloma, Pablo Avanzas, Javier Gualis, Antonio Adeba, Armando Pérez de Prado, César Morís, Felipe Fernández-Vázquez

Cataract complications study: an analysis of adverse effects among 14,520 eyes in relation to surgical experience

Alexander Aaronson, Antti Viljanen, Piotr Kanclerz, Andrzej Grzybowski, Raimo Tuuminen

Cost-effectiveness of intravitreal conbercept versus other treatments for wet age-related macular degeneration

Rui Chen, Bin Wu

Ligustilide modulates oxidative stress, apoptosis, and immunity to avoid pathological damages in bleomycin induced pulmonary fibrosis rats via inactivating TLR4/MyD88/NF-KB P65

Shu Luo, Junzuo Gong, Xiaoping Cao, Shiping Liu

Prognostic factors and the effect of radioiodine on patients with locally advanced differentiated thyroid cancer

Yao Yao, Shuai Cheng, Xinyu Xu, Xinyuan Chen, Wei Chen, Yichun Qian, Yuan Zhang

Which is the optimal management for locally advanced gastric cancer patients with TRG 0 and 1 after R0 resection?

Fei Ma, Yonglei Zhang, Liangqun Peng, Zhandong Zhang, Wei Yang, Junhui Chai, Bin Zhang, Sheqing Ji, Yawei Hua, Xiaobing Chen, Suxia Luo

Antibacterial peptides inhibit MC3T3-E1 cells apoptosis induced by TNF-α through p38 MAPK pathway

Rong-Jian Lu, He-Lin Xing, Chao-Jun Liu, Yao Shu, Biao Guo, Xiao-Yang Chu, Chun-Fang Wang, Lin Feng, Kai-Tao Yu

Estrogen receptor α is involved in the regulation of ITGA8 methylation in estrogen receptor-positive breast cancer

Jingxun Wu, Jianghong Cheng, Fuxing Zhang, Xianyang Luo, Zhiming Zhang, Shuai Chen

Initial experience of a MitraClip valve repair program in Spain

Daniel Henández-Vaquero, Isaac Pascual, Marcel Almendarez, Antonio Adeba, Alberto Alperi, Rebeca Lorca, Héctor Cubero-Gallego, Víctor León, Félix E. Fernández Suárez, David Fernández del Valle, César Morís, Pablo Avanzas

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

Surgical outcomes and survival for T4 gastric cancer extending to the transverse colon

Gang-Cheng Wang, Ying-Jun Liu, Chong-Qing Gao, You-Cai Wang, Hui-Fang Lv, Bei-Bei Chen, Cai-Yun Nie, Xiao-Bing Chen, Su-Xia Luo

The patterns and management of fracture patients under COVID-19 outbreak in China

Pei Yu, Chuanlong Wu, Chengyu Zhuang, Tingjun Ye, Yin Zhang, Jingfeng Liu, Lei Wang

Intensity-modulated particle beam radiation therapy in the management of olfactory neuroblastoma

Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade J. Lu

RACGAP1 is transcriptionally regulated by E2F3, and its depletion leads to mitotic catastrophe in esophageal squamous cell carcinoma

Weifeng Zhao, Mengyao Wang, Chaojie Wang, Yingjun Liu, Huimin Liu, Suxia Luo

A CT-derived deep neural network predicts for programmed death ligand-1 expression status in advanced lung adenocarcinomas

Ying Zhu, Yang-Li Liu, Yu Feng, Xiao-Yu Yang, Jing Zhang, Dan-Dan Chang, Xi Wu, Xi Tian, Ke-Jing Tang, Can-Mao Xie, Yu-Biao Guo, Shi-Ting Feng, Zun-Fu Ke

Obesity and its effect on outcomes in same-day bilateral total knee arthroplasty

Ethan A. Remily, Nequesha S. Mohamed, Wayne A. Wilkie, Tyler Smith, Anthony Judice, Salvador Forte, James Nace, Ronald E. Delanois

ADNCR modulates neural stem cell differentiation and proliferation through the regulation of TCF3 expression

Ling Long, Chao Zeng, Honglei Chen, Taicheng Zhou, Lili Wu, Xiaodong Cai

“Liver parenchyma dissecting-first” method facilitates the Glissonean pedicle approach in anatomical laparoscopic hepatolobectomy

Liang Xiao, Zhiming Wang, Ledu Zhou

Review Article

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Tetralogy of Fallot: cardiac imaging evaluation

Carlos Jerjes Sánchez Ramírez, Leopoldo Pérez de Isla

The modern approach to esophageal palliative and emergency surgery

Anny Godin, Moishe Liberman

Outcomes with percutaneous mitral repair vs. optimal medical treatment for functional mitral regurgitation: systematic review

Hector Cubero-Gallego, Daniel Hernandez-Vaquero, Pablo Avanzas, Marcel Almendarez, Antonio Adeba, Rebeca Lorca, Jose Rozado, Alain Escalera, Jacobo Silva, Cesar Moris, Isaac Pascual

Lung transplantation for emphysema

Ilhan Inci

Lens regeneration in humans: using regenerative potential for tissue repairing

Zhenzhen Liu, Ruixin Wang, Haotian Lin, Yizhi Liu

New frontiers in esophageal radiology

Eric J. Schmidlin, Ritu R. Gill

Catheter-based treatment of tricuspid regurgitation: state of the art

Marcel Santaló-Corcoy, Lluís Asmarats, Chi-Hion Li, Dabit Arzamendi

The emerging prospects of circular RNA in tumor immunity

Lingjiao Meng, Pingan Ding, Sihua Liu, Ziyi Li, Meixiang Sang, Baoen Shan

Timing of carotid endarterectomy and clinical outcomes

Bilal Azhar, Arsalan Wafi, James Budge, Ian Loftus

Brain imaging biomarkers of carotid artery disease

Hediyeh Baradaran, Ajay Gupta

Preoperative planning for intraoperative navigation guidance

Shahbaaz A. Sabri, Philip J. York

Ovarian cancer risk assessment in the era of next-generation sequencing

Renata Colombo Bonadio, Jéssica Rojas Crespo, Maria Del Pilar Estevez-Diz

Fugitive aerosols in the intensive care unit: a narrative review

Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin

Reviewing the value of leukocytes cell population data (CPD) in the management of sepsis

Eloísa Urrechaga

Current practices on genetic testing in ovarian cancer

Florentia Fostira, Marios Papadimitriou, Christos Papadimitriou

Upfront debulking surgery for high-grade serous ovarian carcinoma: current evidence

Orestis Tsonis, Fani Gkrozou, Konstantinos Vlachos, Minas Paschopoulos, Michail C. Mitsis, Nikolaos Zakynthinakis-Kyriakou, Stergios Boussios, George Pappas-Gogos

Metformin and ovarian cancer: the evidence

Elina Urpilainen, Ulla Puistola, Stergios Boussios, Peeter Karihtala

Current innovation in virtual and augmented reality in spine surgery

Frank J. Yuk, Georgios A. Maragkos, Kosuke Sato, Jeremy Steinberger

Intraoperative image guidance for endoscopic spine surgery

Jason I. Liounakos, Gregory W. Basil, Hikari Urakawa, Michael Y. Wang

Narrative review of intraoperative image guidance for transforaminal lumbar interbody fusion

Joseph A. Weiner, Michael H. McCarthy, Peter Swiatek, Philip K. Louie, Sheeraz A. Qureshi

Future of immune checkpoint inhibitors: focus on tumor immune microenvironment

Yunlong Jia, Lihua Liu, Baoen Shan

Fusion imaging for transcatheter mitral and tricuspid interventions

Isaac Pascual, Alberto Pozzoli, Maurizio Taramasso, Francesco Maisano, Edwin C. Ho

Evolving treatment paradigms in esophageal cancer

Ilit Turgeman, Irit Ben-Aharon

The modern approach to esophagectomy—review of the shift towards minimally invasive surgery

Daniel P. Dolan, Scott J. Swanson

Opioid transdermal delivery system: a useful method for pain management in children

Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attinà, Palma Maurizi, Alberto Romano, Antonio Ruggiero

Magnetic resonance imaging of carotid plaques: current status and clinical perspectives

Mohamed Kassem, Alexandru Florea, Felix M. Mottaghy, Robert van Oostenbrugge, M. Eline Kooi

Metabolic programming of tumor associated macrophages in the context of cancer treatment

Thomas Crezee, Katrin Rabold, Lisanne de Jong, Martin Jaeger, Romana T. Netea-Maier

Optical coherence tomography angiography in glaucoma

Masoud Aghsaei Fard, Robert Ritch

Pain assessment in clinical trials: a narrative review

Livia Puljak, Krste Boric, Svjetlana Dosenovic

Intraoperative image guidance for the surgical treatment of adult spinal deformity

Venkat Boddapati, Joseph M. Lombardi, Hikari Urakawa, Ronald A. Lehman

Sharing of decision-making for infective endocarditis surgery: a narrative review of clinical and ethical implications

Francesco Pollari, Cristiano Spadaccio, Michela Cuomo, Massimo Chello, Antonio Nenna, Theodor Fischlein, Francesco Nappi

The role of lens extraction in glaucoma management

Jolly L. Tsui, Noel C. Chan, Clement C. Tham

Management of internal carotid artery near-occlusion: the need for updated evidence

Constantine N. Antonopoulos, Alexandros Giosdekos, Spyridon N. Mylonas, Christos D. Liapis

Inflammation of carotid plaques and risk of cerebrovascular events

Pavel Poredos, Igor D. Gregoric, Mateja K. Jezovnik

Impact of cerebral ischemic lesions on the outcome of carotid endarterectomy

Rodolfo Pini, Andrea Vacirca, Sergio Palermo, Enrico Gallitto, Chiara Mascoli, Mauro Gargiulo, Gianluca Faggioli

Advances in imaging for lung emphysema

Katharina Martini, Thomas Frauenfelder

Treatment for metastatic adenocarcinoma of the stomach and gastroesophageal junction: 2020

Andrew Hsu, Adam S. Zayac, Aditya Eturi, Khaldoun Almhanna

Emerging neo adjuvants for harnessing therapeutic potential of M1 tumor associated macrophages (TAM) against solid tumors: Enusage of plasticity

Vinod Nadella, Manoj Garg, Sonia Kapoor, Tuhar Singh Barwal, Aklank Jain, Hridayesh Prakash

Bronchoscopic lung volume reduction: status quo

Massa Zantah, Andrew J. Gangemi, Gerard J. Criner

Current state of navigation in spine surgery

Nathaniel Rawicki, James E. Dowdell, Harvinder S. Sandhu

The quest for the optimal surgical management of tricuspid valve endocarditis in the current era: a narrative review

Francesco Nappi, Cristiano Spadaccio, Christos Mihos, Kasra Shaikhrezai, Christophe Acar, Marc R. Moon

Intraoperative image guidance for cervical spine surgery

Sertac Kirnaz, Harry Gebhard, Taylor Wong, Raj Nangunoori, Franziska Anna Schmidt, Kosuke Sato, Roger Härtl

Asymptomatic Carotid Stenosis and Risk of Stroke (ACSRS) study: what have we learned from it?

Kosmas I. Paraskevas, Andrew N. Nicolaides, Stavros K. Kakkos

Paraesophageal hernia: to fundoplicate or not?

Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan

Percutaneous mitral repair: current and future devices

Rodrigo Estévez-Loureiro, Tomás Benito-González, Carmen Garrote-Coloma, Felipe Fernández-Vázquez, Pablo Avanzas, Miguel Piñón, Isaac Pascual

Systemic anti-cancer treatment in malignant ovarian germ cell tumours (MOGCTs): current management and promising approaches

Mario Uccello, Stergios Boussios, Eleftherios P. Samartzis, Michele Moschetta

Management of asymptomatic carotid stenosis

J. David Spence

Why are we still debating criteria for carotid artery stenosis?

Victor J. Del Brutto, Heather L. Gornik, Tatjana Rundek

The conundrum of asymptomatic carotid stenosis—determinants of decision and evidence

José Fernandes e Fernandes, Luis Mendes Pedro, Isabel Gonçalves

Treatment of the extracranial carotid artery in tandem lesions during endovascular treatment of acute ischemic stroke: a systematic review and meta-analysis

Joyce Hellegering, Maarten Uyttenboogaart, Reinoud P. H. Bokkers, Mostafa El Moumni, Clark J. Zeebregts, Maarten J. van der Laan

The current state of navigation in robotic spine surgery

Meng Huang, Tyler A. Tetreault, Avani Vaishnav, Philip J. York, Blake N. Staub

Intraoperative risks of radiation exposure for the surgeon and patient

Nathaniel W. Jenkins, James M. Parrish, Evan D. Sheha, Kern Singh

Metabolic reprograming of tumor-associated macrophages

Abhishek Puthenveetil, Shweta Dubey

Advances in pharmacotherapy of cataracts

Jingjie Xu, Qiuli Fu, Xiangjun Chen, Ke Yao

Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis?

Stergios Boussios, Michele Moschetta, Peeter Karihtala, Eleftherios P. Samartzis, Matin Sheriff, George Pappas-Gogos, Mehmet Akif Ozturk, Mario Uccello, Afroditi Karathanasi, Michail Tringos, Elie Rassy, Nicholas Pavlidis

Optical coherence tomography angiography in glaucoma: analysis of the vessel density—visual field sensitivity relationship

Gábor Holló

Carotid intraplaque haemorrhage: pathogenesis, histological classification, imaging methods and clinical value

Mathilde Mura, Nellie Della Schiava, Anne Long, Erica N. Chirico, Vincent Pialoux, Antoine Millon

Lung emphysema and lung cancer: what do we know about it?

Ramón A. Tubío-Pérez, María Torres-Durán, Mónica Pérez-Ríos, Alberto Fernández-Villar, Alberto Ruano-Raviña

Targeted therapies for gastroesophageal cancers

Andrew Hsu, Rani Chudasama, Khaldoun Almhanna, Alexander Raufi

Locoregional gastric cancer: a narrative review of multidisciplinary management

Ari Pelcovits, Khaldoun Almhanna

A narrative review of the interpretation of guidelines for the treatment of infective endocarditis

Umberto Benedetto, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Marc R. Moon, Francesco Nappi

Diabetes and carotid artery disease: a narrative review

Niki Katsiki, Dimitri P. Mikhailidis

Cholesterol, carotid artery disease and stroke: what the vascular specialist needs to know

Kosmas I. Paraskevas, Frank J. Veith, Hans-Henning Eckstein, Jean-Baptiste Ricco, Dimitri P. Mikhailidis

Transcatheter aortic valve replacement (TAVR): expanding indications to low-risk patients

Hector Cubero-Gallego, Christian Dam, Juan Meca, Pablo Avanzas

Choice of transcatheter heart valve: should we select the device according to each patient’s characteristics or should it be “one valve fits all”?

Matthias Renker, Won-Keun Kim

Pulmonary regurgitation after repaired tetralogy of Fallot: surgical versus percutaneous treatment

Juan Antonio Meca Aguirrezabalaga, Jacobo Silva Guisasola, Rocío Díaz Méndez, Alain Eliott Escalera Veizaga, Daniel Hernández-Vaquero Panizo

The management of carotid restenosis: a comprehensive review

Francesco Stilo, Nunzio Montelione, Rosalinda Calandrelli, Marisa Distefano, Francesco Spinelli, Vincenzo Di Lazzaro, Fabio Pilato

The less invasive paradox, why carotid artery stenting is not suitable for the high-risk patient

Matthew Machin, Safa Salim, Sarah Onida, Alun Huw Davies

Management and prognosis of acute extracranial internal carotid artery occlusion

Lukas Mayer, Astrid Grams, Christian F. Freyschlag, Maria Gummerer, Michael Knoflach

CT imaging features of carotid artery plaque vulnerability

Alessandro Murgia, Marco Erta, Jasjit S. Suri, Ajay Gupta, Max Wintermark, Luca Saba

Approaches to quantify optical coherence tomography angiography metrics

Bingyao Tan, Ralene Sim, Jacqueline Chua, Damon W. K. Wong, Xinwen Yao, Gerhard Garhöfer, Doreen Schmidl, René M. Werkmeister, Leopold Schmetterer

Robotics and minimally invasive esophageal surgery

Ealaf Shemmeri, Jon O. Wee

Redo aortic valve replacement for prosthesis endocarditis in patients previously classified as high or prohibitive risk: a narrative review

Francesco Pollari, Renate Ziegler, Francesco Nappi, Irena Großmann, Jörg Steinmann, Theodor Fischlein

Revisiting the guidelines and choice the ideal substitute for aortic valve endocarditis

Francesco Nappi, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Christophe Acar

Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes

Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique

Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery

Luigi Bonavina

Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry

Renato Salvador, Mario Costantini, Salvatore Tolone, Pietro Familiari, Ermenegildo Galliani, Bastianello Germanà, Edoardo Savarino, Stefano Merigliano, Michele Valmasoni

Fluorescence-guided surgery of the esophagus

Paul Chandler, Ory Wiesel, Danny A. Sherwinter

Narrative review on serous primary peritoneal carcinoma of unknown primary site: four questions to be answered

Elie Rassy, Tarek Assi, Stergios Boussios, Joseph Kattan, Julie Smith-Gagen, Nicholas Pavlidis

A pilot protocol and review of triple neuroprotection with targeted hypothermia, controlled induced hypertension, and barbiturate infusion during emergency carotid endarterectomy for acute stroke after failed tPA or beyond 24-hour window of opportunity

Sherif Sultan, Yogesh Acharya, Nora Barrett, Niamh Hynes

Postoperative Endophthalmitis and Toxic Anterior Segment Syndrome Prophylaxis: 2020 Update

Jesse D. Sengillo, Ying Chen, Diley Perez Garcia, Stephen G. Schwartz, Andrzej Grzybowski, Harry W. Jr Flynn

Endometriosis and ovarian cancer risk, an epigenetic connection

Sarah Brunty, Brenda Mitchell, Nadim Bou-Zgheib, Nalini Santanam

Personalized-medicine on carotid endarterectomy and stenting

Gaetano Lanza, David Giannandrea, Jessica Lanza, Stefano Ricci, Gian Franco Gensini

Neoadjuvant treatment for newly diagnosed advanced ovarian cancer: where do we stand and where are we going?

Michele Moschetta, Stergios Boussios, Elie Rassy, Eleftherios P. Samartzis, Gabriel Funingana, Mario Uccello

Current and future immunotherapy approaches in ovarian cancer

Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk

Intraoperative image guidance for lateral position surgery

Peter R. Swiatek, Michael H. McCarthy, Joseph Weiner, Shivani Bhargava, Avani S. Vaishnav, Sravisht Iyer

Column in Laboratory Medicine

SARS-CoV-2 antibodies titration: a reappraisal

Giuseppe Lippi, Mario Plebani

Erratum

Erratum to dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2

Meng Chi, Xiaoding Shi, Xing Huo, Xiaohong Wu, Pinyi Zhang, Guonian Wang

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.