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Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care” edited by Prof. Keith C. Ferdinand

This special issue of the ATM provides perspectives on cardiovascular disease (CVD) not only in the United States (US), but also worldwide. We present a global, comprehensive view of innovative research, reviews, editorials and perspectives from basic science at the bench level to clinic interventions and public health considerations. While this edition of ATM builds on much of the research and clinical care conducted at Tulane University School of Medicine in New Orleans, Louisiana, USA, it also highlights provocative insights from other authors from the USA, along with articles from basic science researchers, clinicians and public health specialists from Africa, Europe, Asia and South America.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Focus on “Molecular Medicine” edited by Dr. Christina Piperi and Dr. Athanasios G. Papavassiliou

Welcome to this thematic issue of Annals of Translational Medicine on the recent advances of the ever-expanding field of molecular medicine. The present volume attempts to cover current genetic, molecular, or cellular aspects of main subject areas including microbiology, haematology, biomechanics, oncology, endocrinology, pharmacology, cardiology and hepatology. It is primarily focused on recent developments on molecular biomarkers and current technologies that elucidate disease pathogenesis and may lead to the design of specific tools for diagnosis, treatment, or disease prevention

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Articles from these leading researchers, taken together, effectively paint the picture on a wide canvas and shine a spotlight on critical issues facing the translational oncology community. These leading experts provide a state-of-the-art assessment of timely questions spanning cancer research, from bedside to clinic (and back), including but not limited to accurate molecular assessment of genomic profiles, predictive and prognostic biomarkers, determination of appropriate treatments based on economic profiles, and also the financial toxicity stemming from the recent new wave of effective but expensive cancer-targeting therapies in lung cancer, breast cancer, colorectal cancer, and prostate cancer.

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Lung cancer remains the leading cause of cancer related death worldwide, with approximately 1.6 million deaths recorded in 2015. Non-small cell lung cancer (NSCLC) accounts for approximately 80–85% of cases. Despite broad advances in diagnostics and therapy, the 5-year overall survival for patients with advanced NSCLC has not significantly changed over the past few years. Following the decoding of human cancer genome and the advent of therapies targeting driver mutations, the choice of systemic therapy changed from “one size fits all” approach to a more precise selection of biologic therapies targeting distinct genetic profiles, the so-called “precision” medicine.

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

Good news continues to roll in! Announced by Clarivate Analytics, former Thomson Reuters Intellectual Property and Science Business, Annals of Translational Medicine (known as ATM), under AME Publishing Company, is officially indexed in Science Citation Index Expanded (SCIE) on 02 March, 2018

2017 Annual Report of ATM

We are glad to present the 2017 Annual Report of ATM here. In 2017, ATM progressed fast and smoothly under the join-efforts of experts worldwide. The total citation number has significantly increased from 1294 in January to 3314 in December. The journal was also exhibited in some international meetings, to attract wider attention and exposure. More information is shown in the Annual Report.
We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy, healthy and prosperous 2018!

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

Sleep apnea is associated with worse outcomes following various kinds of surgeries. There is a paucity of data on the association of sleep apnea with clinical outcomes after transcatheter aortic valve replacement (TAVR).

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

Allenbach and colleagues have recently reported for the first time the results of an intriguing study of the histopathologic, immunopathologic and gene expression differences in muscle biopsy tissue from adult dermatomyositis (DM) patients who do and do not have circulating MDA5 autoantibodies (anti-MDA5). Anti-MDA5 were originally identified in a clinically-defined subset of DM patients whose disease was expressed predominately in the skin for unusually long periods of time without accompanying muscle weakness [i.e., “clinically-amyopathic DM” (CADM)] and were at risk for acute, rapidly-progressive form of interstitial lung disease (ILD)...

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Vol 6, No 21 (November, 2018)

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Focused Issues more

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to... More >>

Focus on “Cardiopulmonary Interactions” More >>

Focus on “Rare and orphan disorders: an emerging challenge?” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Preface

Hot topics in ventilator-associated pneumonia

Saad Nseir, Ignacio Martin-Loeches

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Original Article

Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia

Raquel Almansa, Leonor Nogales, Marta Martín-Fernández, Montse Batlle, Esther Villareal, Lucia Rico, Alicia Ortega, Guillermo López-Campos, David Andaluz-Ojeda, Paula Ramírez, Lorenzo Socias, Luis Tamayo, Jordi Vallés, Jesús F. Bermejo-Martín, Ignacio Martín-Loeches

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Impact of subglottic secretion drainage on microaspiration in critically ill patients: a prospective observational study

Guillaume Millot, Pauline Boddaert, Erika Parmentier-Decrucq, Aurore Palud, Malika Balduyck, Patrice Maboudou, Farid Zerimech, Frédéric Wallet, Sébastien Preau, Saad Nseir

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Impact of hyperoxemia on mortality in critically ill patients with ventilator-associated pneumonia

Sophie Six, Anahita Rouzé, Olivier Pouly, Julien Poissy, Frédéric Wallet, Sébastien Preau, Saad Nseir

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Review Article

Lung ultrasound for diagnosis and monitoring of ventilator-associated pneumonia

Bélaïd Bouhemad, Ophélie Dransart-Rayé, Francesco Mojoli, Silvia Mongodi

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Is intra-abdominal hypertension a risk factor for ventilatorassociated pneumonia?

Eleni Papakrivou, Eustratios Manoulakas, Epaminondas Zakynthinos, Demosthenes Makris

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“The multimodal approach for ventilator-associated pneumonia prevention”—requirements for nationwide implementation

Francisco Álvarez-Lerma, M. Sánchez-García, Task Force of Experts for Project “Zero

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Are tracheal surveillance cultures useful in the intensive care unit?

Sandrine Dray, Benjamin Coiffard, Nicolas Persico, Laurent Papazian, Sami Hraiech

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Subglottic secretion drainage for ventilator-associated pneumonia prevention: an underused efficient measure

Jean-Claude Lacherade, Marie-Ange Azais, Caroline Pouplet, Gwenhael Colin

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New treatments of multidrug-resistant Gram-negative ventilatorassociated pneumonia

Garyphallia Poulakou, Styliani Lagou, Drosos E. Karageorgopoulos, George Dimopoulos

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Ventilator-associated pneumonia related to ESBL-producing gram negative bacilli

Benoit Pilmis, Jean-Ralph Zahar

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Ventilator-associated events versus ventilator-associated respiratory infections—moving into a new paradigm or merging both concepts, instead?

Sergio Ramirez-Estrada, Yolanda Peña-Lopez, Vandana Kalwaje Eshwara, Jordi Rello

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Oropharyngeal colonization: epidemiology, treatment and ventilator-associated pneumonia prevention

Jonathan Messika, Béatrice La Combe, Jean-Damien Ricard

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Ventilator-associated pneumonia in extracorporeal membrane oxygenation-assisted patients

Guillaume Franchineau, Charles Edouard Luyt, Alain Combes, Matthieu Schmidt

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Editorial

Relationship between microaspiration of gastric contents and ventilator-associated pneumonia

Anahita Rouzé, Emmanuelle Jaillette, Saad Nseir

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Are there more differences or similarities between the hospital-acquired pneumonia guidelines?

Andre C. Kalil, Mark M. Metersky

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Editorial

Hyperphosphatemia: a novel risk factor for mortality in chronic kidney disease

Mario Cozzolino, Paola Ciceri, Andrea Galassi

Trends in ACL reconstruction: an “individualized approach”

Philippe Landreau

Translational animal models for endometriosis research: a long and windy road

Antonio Simone Laganà, Simone Garzon, Massimo Franchi, Jvan Casarin, Giuseppe Gullo, Fabio Ghezzi

Calcium and/or vitamin D supplementation: could they affect your risks of colorectal cancer development or progression?

Lynnette R. Ferguson

Search for a reliable biomarker of acute kidney injury: to the heart of the problem

Luca Di Lullo, Biagio Raffaele Di Iorio, Claudio Ronco, Antonio Bellasi

The new basal insulin analog glargine U-300 enables flexible injection schedule

Uru Nezu Osada, Yasuo Terauchi

HLA-B*58:01 is not the only risk factor associated with allopurinol-induced severe cutaneous adverse drug reactions

Margarida Gonçalo

Molecular imaging in large vessel vasculitis has come to stay

Isabel Martínez-Rodríguez, Miguel A. González-Gay, Diana Prieto-Peña, Ignacio Banzo

TBX20 and the PROK2-PROKR1 pathway—new kid on the block in angiogenesis research

Michael Lichtenauer, Christian Jung

Tumor inactivation of E-cadherin: a new tool for breast cancer treatment?

Giovanni Corso, Bernardo Bonanni, Paolo Veronesi

Durability of mitral valve repair for degenerative mitral regurgitation: is it gold all that glitters?

Antonio M. Calafiore, Antonio Totaro, Massimiliano Foschi, Michele Di Mauro

Anticoagulation after mechanical aortic valve implantation: is it time to act after PROACT?

Mevlüt Çelik, Andras P. Durko, Stuart J. Head

Self-condensation culture for vascularized organoid

Shoichiro Sumi

The benefits of youth sports participation should outweigh the risks

Carola F. van Eck, Freddie H. Fu

Is B-type natriuretic peptide (BNP) similarly associated with mortality in patients with and without heart failure?

Norihide Fukushima

Extracorporeal membrane oxygenation in acute respiratory distress syndrome: why is the EOLIA trial important?

Nicolas Persico, Christophe Guervilly, Antoine Roch, Laurent Papazian

Osteochondral lesions of the talus: are we ready for metal?

Riccardo D’Ambrosi, Federico Giuseppe Usuelli

Evaluation of kinematic changes of intervertebral discs and the space available for the cord

Federico Canavese, Yann Philippe Charles, Alain Dimeglio

Adult mesenchymal stem cells for the treatment in patients with rotator cuff disease: present and future direction

Dong Rak Kwon, Gi-Young Park

Local modalities for inoperable hepatocellular carcinoma: radiofrequency ablation versus stereotactic body radiotherapy

Sun Hyun Bae, Hee Chul Park

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Genetics in systemic lupus erythematosus: entering the borough of cardiovascular risk

Giuseppe A. Ramirez

LXRs are finally being adequately targeted in atherosclerosis

Julio Buñay, Silvère Baron, Jean-Marc A. Lobaccaro

Immunoscore—has it scored for colon cancer precision medicine?

Robert N. Jorissen, Anuratha Sakthianandeswaren, Oliver M. Sieber

Surrogate study endpoints in the era of cancer immunotherapy

Tsuyoshi Hamada, Keisuke Kosumi, Yousuke Nakai, Kazuhiko Koike

The hemodynamic effects of norepinephrine: far more than an increase in blood pressure!

Pierre Foulon, Daniel De Backer

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Validating innovations to improve recovery after heart surgery

Ali Fatehi Hassanabad, Paul W. M. Fedak

High-density lipoprotein lifts the “dark web” cast by neutrophils

Diego Lucero, Edward B. Neufeld, Alan T. Remaley

EBOV-RNA test with RT-PCR in ocular fluids of Ebola survivors can help to safely perform cataract surgery

Leopoldo Spadea, Nicola Iozzo

Reforming disease classification system—are we there yet?

Mikhail G. Dozmorov

The status of medical expulsive therapy in the age of evidence-based medicine

Julian Veser, Christian Seitz

Treatment of induction in resectable NSCLC with chemotherapy, followed by surgery and erlotinib

Fernando Franco, Mariano Provencio

Silent myocardial infarction and risk of heart failure

Timir K. Paul, Debabrata Mukherjee

Endoscopic saphenous vein harvesting and surgical site infections after coronary artery bypass surgery

Antonio Salsano, Giovanni Mariscalco, Francesco Santini

The answer is cilia, whatever the question may be!

Andrew Bush, Claire Hogg

Treating atherosclerosis: targeting risk factors should not be the only option

Montserrat Fibla, Anna Hernández-Aguilera, Jordi Camps, Javier A. Menendez, Jorge Joven

Screening of three-dimensional spheroids of ovarian cancer: identification of novel therapeutics targeting stemness and chemoresistance

Neveen Said

Simulation modeling for clinical trials evaluating radiotherapy omission in low-risk early breast cancer

Pierfrancesco Franco, Umberto Ricardi

Host-pathogen interactions in typhoid fever: the model is the message

Verónica Urdaneta, Josep Casadesús

Ebola virus and persistent chronic infection: when does replication cease?

John V. Forrester

Re-biopsy in lupus nephritis

Hans-Joachim Anders

The fecal microbiome directly drives immune activation in HIV infection

Camilla Tincati, Giuseppe Ancona, Giulia Marchetti

Pacific Rim redux: lorlatinib, the ultimate Jaeger?

Viola W. Zhu, Sai-Hong Ignatius Ou

We should not avoid diclofenac in the treatment of spondyloarthritis

Gerhard Zingler, Thomas Herdegen

Neuropathic pain models and outcome measures: a dual translational challenge

Robert D. E. Sewell

Targeting selected extracellular matrix components to attenuate cardiac fibrosis

Simranjit S. Pattar, Ali Fatehi Hassanabad, Paul W. M. Fedak

Progressive nature of myocardial fibrosis in pediatric hypertrophic cardiomyopathy: from mutation carrier to myocardial fibrosis

Hong-Mi Choi, Hyung-Kwan Kim

Non-invasive assessment of tumor PD-L1 status with circulating tumor cells

Bryan C. Ulrich, Nicolas Guibert

Cardiovascular risk prediction in older adults with the use of biomarkers

Alexandros Briasoulis, Rabea Asleh

Risk of peripheral artery disease in human immunodeficiency virus infected individuals

Kevin Belgrave, Kashif Shaikh, Matthew J. Budoff

Standardising measures in pediatric rheumatology: the experience of the international consensus dataset for juvenile dermatomyositis

Giovanni Filocamo

Issues in implementing lung cancer screening in United States and Europe

Giuseppe Gorini, Giulia Carreras

Discovering the genetic contribution to cardiovascular diseases in patients affected by autoimmune diseases

Cinzia Ciccacci

MK-2206 window of opportunity study in breast cancer

Argun Akcakanat, Funda Meric-Bernstam

New highlight in breast cancer development: the key role of hepcidin and iron metabolism

Manuel Scimeca, Elena Bonanno

Cerebrovascular contribution to dementia development after traumatic brain injury: promises and problems

Lyndsey Collins-Praino, Frances Corrigan

Radiologic features of small pulmonary nodules detected in initially negative screening CT examinations: a step towards personalized screening strategies?

Gorka Bastarrika, Juan Pablo de-Torres, Javier J. Zulueta

The different path of T790M-positive EGFR-mutant lung cancer

Shinkyo Yoon, Chang Min Choi, Jae Cheol Lee

The risk factors for brain metastases in patients with non-small cell lung cancer

Jun Hyeok Lim, Sang-Won Um

Cholesterol homeostasis, macrophage malfunction and age-related macular degeneration

Mei Chen, Chi-Chao Chan, Heping Xu

Concurrent chemoradiotherapy for stage III non-small cell lung cancer: correct clinical management as the basis to move beyond

Guilherme Jorge Costa, Carlos Gil Ferreira, Luiz Claudio Santos Thuler

Epithelial plasticity is crucial for pancreatic cancer metastatic organotropism

Aleksandra Adamska, Marco Falasca

Microbial marauders: pancreatic microbiota and its impact on carcinogenesis

Ryan M. Thomas, Maria Zajac-Kaye

Cardioprotective effects of autophagy induction in sepsis

Mahmoud Abdellatif, Simon Sedej, Frank Madeo, Guido Kroemer

Prediction of therapeutic effects of human cardiomyocytes in myocardial infarction using non-human primates model

Hyun-Min Cho, Je-Yoel Cho

Targeting properdin in the treatment of atypical haemolytic uraemic syndrome: better than eculizumab?

Kate Smith-Jackson, Kevin J. Marchbank

Understanding the link between traumatic brain injury and Alzheimer’s disease

Brandon Lucke-Wold

Office-based spirometry to stratify the risk of postoperative complications

Shigeki Suzuki, Yusuke Takahashi

Novel mediators of breast cancer bone metastasis—insights from studies of gene-regulation and the global proteome

Janet E. Brown, Steven L. Wood

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Patient friendly intensification of basal insulin

Sanjay Kalra

Effect of sodium-glucose cotransporter type 2 inhibitors on liver fat in patients with type 2 diabetes: hepatic beyond cardiovascular and renal protection?

André J. Scheen

Laparoscopic Roux-en-Y gastric bypass or vertical sleeve gastrectomy: a weighty decision

Emma J. Osland, Muhammed Ashraf Memon

Cardiovascular disease in the youngest: is it time for precision prevention?

Giovanni Veronesi, Andrea M. Maresca

Robotic-arm assisted total hip arthroplasty

Matthew S. Hepinstall, Nipun Sodhi, Joseph O. Ehiorobo, Shazaan Hushmendy, Michael A. Mont

Sphingolipid metabolism products: potential new players in the pathogenesis of bortezomib-induced neuropathic pain

Albert Alé, Andreas A. Argyriou, Jordi Bruna

Pharmacotherapy for gestational diabetes mellitus: still insulin, or what about sulfonylureas?

Angelo Maria Patti, Rosaria Vincenza Giglio, Kalliopi Pafili, Manfredi Rizzo, Nikolaos Papanas

Look around your target: a new approach to early diagnosis of lung cancer

Vito R. Papapietro, Gianluca Milanese, Andrea Borghesi, Nicola Sverzellati, Mario Silva

Health-related quality of life after curative-intent treatment of nonsmall cell lung cancer: can exercise lessen the burden?

Rosie Twomey, Gwyn Bebb, S. Nicole Culos-Reed

TAILORing targeted therapies to the right patient at the right time: how close are we?

George Zarkavelis, George Pentheroudakis

Out of darkness comes light—is there a role for light masks in treatment of diabetic macular oedema?

Mali Okada, Jay Chhablani

A pathogenic hierarchy for synovial fibroblasts in rheumatoid arthritis

Mohammed H. Abuwarwar, Konstantin Knoblich, Anne L. Fletcher

Testosterone replacement in androgen insensitivity: is there an advantage?

Rafael Loch Batista, Berenice Bilharinho Mendonca

Inferior vena cava variation predicts fluid responsiveness during dysrhythmias: a rational rearrangement of chairs on The Titanic

Rory J. Spiegel, Michael T. McCurdy

Post-immunotherapy new onset diabetes (PINOD)—underrecognized etiology, unexplored presentation

Sanjay Kalra

Is there a relation between preserved renal function and oncological outcomes in patients undergoing partial nephrectomy for renal cell carcinoma?

Alessandro Veccia, Riccardo Autorino

Simulation modeling approaches to answer clinically relevant questions in breast cancer low-risk populations

Ana Calin, Miguel Martin, Sara Lopez-Tarruella

Clinical benefit of treatment for metastatic renal cell cancer at high volume facilities

Waqar Haque, Monty Aghazadeh, Brian J. Miles, Raj Satkunasivam, E. Brian Butler, Bin S. Teh

Mid-term results of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy compared—results of the SLEEVEPASS and SM-BOSS trials

David Benaiges, Elisenda Climent, Albert Goday, Helena Julià, Juana A. Flores-Le Roux, Juan Pedro-Botet

BCMA CAR T-cell therapy arrives for multiple myeloma: a reality

Shih-Feng Cho, Kenneth C. Anderson, Yu-Tzu Tai

Cardiovascular disease in patients with rheumatoid arthritis: impact of classic and disease-specific risk factors

Giulio Cavalli, Ennio Giulio Favalli

Radiogenomics as association between non-invasive imaging features and molecular genomics of lung cancer

Stefania Rizzo, Filippo Savoldi, Duccio Rossi, Massimo Bellomi

New perspectives on the role of anti-Müllerian hormone (AMH) in women

Renato Pasquali

Increased circulating choline, L-carnitine and TMAO levels are related to changes in adiposity during weight loss: role of the gut microbiota?

Ellen E. Blaak, Emanuel E. Canfora

CircPVT1: a bridge linking Hippo pathway and human cancers

Xiaoyun He, Weiping Su, Yangying Zhou, Xiaolu Ge, Jianhua Zhou, Chunlin Ou

Endogenous sex hormones and cardiovascular disease in postmenopausal women: new but conflicting data

Pierre-Yves Scarabin

VEGF inhibitors in EGFR-mutated lung cancer: a never-ending story?

Mariam Alexander, Balazs Halmos

Review Article

Transcription regulation of MYB: a potential and novel therapeutic target in cancer

Partha Mitra

The role of integrated behavioral health in caring for patients with metabolic disorders

Neelkamal Soares, Roger W. Apple, Shibani Kanungo

Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma mass spectrometry

Sabine Weiskirchen, Philipp Kim, Ralf Weiskirchen

Reverse Takotsubo cardiomyopathy: a comprehensive review

Hamza H. Awad, Ashley R. McNeal, Hemant Goyal

Glycogen metabolism and glycogen storage disorders

Shibani Kanungo, Kimberly Wells, Taylor Tribett, Areeg El-Gharbawy

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Fatty acid oxidation disorders

J. Lawrence Merritt II, Marie Norris, Shibani Kanungo

Role of spironolactone in the treatment of heart failure with preserved ejection fraction

Constantine E. Kosmas, Delia Silverio, Andreas Sourlas, Peter D. Montan, Eliscer Guzman

Original Article

Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer’s disease: a multicenter pilot study

Ying Gao, Xia Li, Xiao-Hong Liu, Qian-Hua Zhao, Xiang-Qian Che, Qi-Hao Guo, Ru-Jing Ren, Gang Wang

Overview the effect of statin therapy on dementia risk, cognitive changes and its pathologic change: a systematic review and meta-analysis

Xi-Chen Zhu, Wen-Zhuo Dai, Tao Ma

Long-term effects of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: systematic review and single-arm meta-analyses

Zongshi Qin, Jiani Wu, Chang Xu, Xiaopu Sang, Xiao Li, Guangrui Huang, Zhishun Liu

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI

Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models

John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann

Not all primary total hip arthroplasties are equal—so is there a difference in reimbursement?

Nipun Sodhi, Sarah E. Dalton, Luke J. Garbarino, Peter A. Gold, Nicolas S. Piuzzi, Jared M. Newman, Anton Khlopas, Assem A. Sultan, Morad Chughtai, Michael A. Mont

Machine learning for semiautomated classification of glioblastoma, brain metastasis and central nervous system lymphoma using magnetic resonance advanced imaging

Nathaniel C. Swinburne, Javin Schefflein, Yu Sakai, Eric K. Oermann, Joseph J. Titano, Iris Chen, Sayedhedayatollah Tadayon, Amit Aggarwal, Amish Doshi, Kambiz Nael

Patient satisfaction and outcomes of static progressive stretch bracing: a 10-year prospective analysis

Nipun Sodhi, Benjamin Yao, Hiba K. Anis, Anton Khlopas, Assem A. Sultan, Jared M. Newman, Michael A. Mont

A real-world study on adverse drug reactions to Xuebijing injection: hospital intensive monitoring based on 93 hospitals (31,913 cases)

Rui Zheng, Hui Wang, Zhi Liu, Xiaohui Wang, Jing Li, Xiang Lei, Yilin Fan, Si Liu, Zhiqiao Feng, Hongcai Shang

Surgical versus conservative therapy for multiple rib fractures: a retrospective analysis

Yongjing Liu, Shun Xu, Qi Yu, Yu Tao, Leilei Peng, Shengbo Qi, Hao Han, Mengran Chen

Efficacy and safety of levosimendan in Chinese elderly patients with Takotsubo syndrome

Yi Guo, Chaofei Zhou, Xia Yang

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR

Shun Fang, Yefeng Shen, Bin Chen, Yuanzhou Wu, Longfei Jia, Yaling Li, Yaru Zhu, Yusheng Yan, Man Li, Rui Chen, Linlang Guo, Xin Chen, Qunqing Chen

Elevation of serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations and its possible atherogenic role in patients with systemic lupus erythematosus

Chenglong Fang, Tingting Luo, Ling Lin

Relationship between surgeon volume and outcomes in spine surgery: a dose-response meta-analysis

Hui-Zi Li, Zhong Lin, Zong-Ze Li, Zeng-Yan Yang, Yang Zheng, Yong Li, Hua-Ding Lu

Single-stage hybrid localization: a combination of bronchoscopic lung mapping followed by post-mapping computed tomographic reconstruction and additional transthoracic needle localization in a cone beam computed tomography room

Shun-Mao Yang, Wei-Chun Ko, Ling-Hsuan Meng, Li-Wei Chen, Kun-Hsien Lin, Yueh-Lun Liu, Shao-En Sun, Huan-Jang Ko

Surgical approach for Siewert type II adenocarcinoma of the esophagogastric junction: transthoracic or transabdominal? —a single-center retrospective study

Zi-Feng Yang, De-Qing Wu, Jun-Jiang Wang, Xing-Yu Feng, Jia-Bin Zheng, Wei-Xian Hu, Yong Li

Red blood cell distribution width (RDW) is an independent predictor of post-implantation syndrome in patients undergoing endovascular aortic repair for abdominal aortic aneurysm

Gian Franco Veraldi, Luca Mezzetto, Lorenzo Scorsone, Marco Macrì, Chiara Bovo, Fabio Simoncini, Paolo Criscenti, Giuseppe Lippi

Unstable angina: trends and characteristics associated with length of hospitalization in the face of diminishing frequency—an evidence of a paradigm shift

Aaqib H. Malik, Nauman Siddiqui, Wilbert S. Aronow

Preoperative short-term fasting protects liver injury in patients undergoing hepatectomy

Chuanfei Zhan, Xinzheng Dai, Gefengqiang Shen, Xu Lu, Xuehao Wang, Ling Lu, Xiaofeng Qian, Jianhua Rao

Retrospective study on the effects of the prognosis of patients treated with extracorporeal membrane oxygenation combined with continuous renal replacement therapy

Ping He, Shixin Zhang, Bingyang Hu, Wei Wu

Serum uric acid and high-risk pregnancy: an intriguing correlation in advanced pregnant women

You-Fan Peng, Xiang-Hui Su, Man-Man Han, Xiang-Yun Zhu, Ling Li

Case Report

Use of an offset head center acetabular shell in difficult primary total hip arthroplasties

Andrew J. Wassef, Anton Khlopas, Nipun Sodhi, Assem A. Sultan, Nicolas S. Piuzzi, Morad Chughtai, Kim L. Stearns, Robert Molloy, Michael A. Mont

Two cases of response to pembrolizumab in epidermal growth factor receptor mutated lung adenocarcinoma patients with programmed death-ligand 1 overexpression

Takeshi Uenami, Mikako Ishijima, Masaki Kanazu, Hiroyuki Kurebe, Ryuya Edahiro, Kohei Nishida, Yuki Akazawa, Yukihiro Yano, Toshihiko Yamaguchi, Masahide Mori

Meet the Professor

Interview questions for Dr. Divya Khosla

Elva S. Zheng

Study Protocol

Acupuncture combined with herbal medicine versus herbal medicine alone for plaque psoriasis: a systematic review protocol

Shiju Xiao, Bo Li, Shuo Feng, Cunzhi Liu, Guangzhong Zhang

Efficacy and safety of Shen-Yuan-Dan capsules for peri-procedural myocardial injury following percutaneous coronary intervention: study protocol for a randomized, double-blind, placebo-controlled trial

Xiang Li, Xiao-Lei Lai, Yu-Tong Fei, Ju-Ju Shang, Qi Zhou, Xue-Yan Sun, Wen-Long Xing, Si-Han Jia, Hong-Xu Liu

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Focus on “Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care” edited by Prof. Keith C. Ferdinand

Introduction of ATM “Corresponding Authors” Column

Focus on “Molecular Medicine” edited by Dr. Christina Piperi and Dr. Athanasios G. Papavassiliou

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

2017 Annual Report of ATM

Artificial Intelligence (AI) in Medicine: Evolving with the Times

Rare diseases: exploration never ceases

Testimonials for ATM from Eminent Experts Worldwide

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

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Preface

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Review Articles

Highlighted Reports in Galectins

Helicobacter Pylori

Big-data Clinical Trial Column

Review Article on MicroRNAs, Signalling Pathways and Diseases

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Letter to the Editor

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Highlighted Reports in Galectins

Editorial: Diabetes Mellitus

Helicobacter Pylori

Review Article on MicroRNAs, Signalling Pathways and Diseases

Review Article on Toward Precision Medicine in Neurological Diseases

Focus on Toward Precision Medicine in Neurological Diseases

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Editorial