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Which lessons shall we learn from the 2019 novel coronavirus outbreak?

Two decades after the severe acute respiratory syndrome (SARS), and one decade after the middle east respiratory syndrome (MERS), a new outbreak of respiratory illness sustained by a member of the coronavirus (CoV) family has been first identified in Wuhan (Hubei Province, China), and is rapidly spreading around the world. The pathogen, temporarily defined 2019 novel coronavirus (2019-nCoV), is a positive-sense RNA, 29903-bp betacoronavirus, first isolated in the Wuhan seafood market on January 7, 2020, and which is highly homologous to the previous SARS CoV.

Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in China. Two cases of neonates with positive 2019-nCoV tests have been reported. Due to the immature immune system and the possibility of vertical transmission from mother to infant, neonates have become a high-risk group susceptible to 2019-nCoV, which emphasize a close cooperation from both perinatal and neonatal pediatrics. In neonatal intensive care unit (NICU), to prevent and control infection, there should be practical measures to ensure the optimal management of children potentially to be infected. According to the latest 2019-nCoV national management plan and the actual situation, the Chinese Neonatal 2019-nCoV expert working Group has put forward measures on the prevention and control of neonatal 2019-nCoV infection. Read More>>

How does Wuhan respond to 2019-nCoV outbreak when the Spring Festival comes

According to the information released by Pepole’s Daily & DXY, (www.dxy.cn, the largest physician community in China), by 17:30 January 22, a total of 456 2019-nCoV cases had been reported in China, among which 25 were cured, and 9 died. The remaining patients had stable conditions and are isolated and treated in local designated hospitals.

Focused Issue on Ovarian Cancer: State of the Art and Perspectives of Clinical Research

This focused issue on Ovarian Cancer: State of the Art and Perspectives of Clinical Research is edited by Dr. Stergios Boussios, MD, MSc, PhD, MRCP, from Department of Medical Oncology, Medway NHS Foundation Trust, Kent, UK; and Dr. Nicholas Pavlidis, MD, PhD, FRCP, from University of Ioannina, Ioannina, Greece.

Focused Issue on Gastroesophageal Cancer 2020

This Focused Issue on “Gastroesophageal Cancer 2020” is edited by Khaldoun Almhanna, MD, MPH, from Department of Hematology/Oncology, Lifespan Cancer Institute, Providence, RI, USA.

Focused Issue on Pain Therapy

This Focused Issue on “Pain Therapy” is edited by Dr. Antonio Ruggiero from Paediatric Oncology Unit, Department of Woman and Child Health, Agostino Gemelli Hospital, Catholic University of Rome, Largo Agostino Gemelli 8, 00168, Rome, Italy.

Focused Issue on Endovascular Interventions in Trauma

This Focused Issue on “Endovascular Interventions in Trauma” is edited by Dr. Keith Bertram Quencer from Division of Interventional Radiology, Department of Radiology, University of Utah, Salt Lake City, UT, USA.

Focused Issue on Lung Emphysema

This focused issue on Lung Emphysema is edited by Dr. Bassam Redwan, MD, from Department of Thoracic Surgery, Klinikum Westfalen, Lünen, Germany.

Focused Issue on Lipid-Modifying Therapies Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)

This Focused Issue on “Lipid-Modifying Therapies Targeting Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)” is edited by Dr. Constantine E. Kosmas, Director of Nuclear Cardiology and Lipid Clinic, Cardiology Unlimited, P.C., New York, NY, USA.

Focused Issue on Tumor Associated Macrophages in Solid Tumor: Friend or Foe

This focused issue on Tumor Associated Macrophages in Solid Tumor: Friend or Foe is edited by Dr. Gaurav Pandey, PhD, from Washington University School of Medicine, St. Louis, MO, USA.

Focused Issue on Current Trends and Advancements in Spine Surgery

In this focused issue of Annals of Translational Medicine, world-renowned leaders, academics, and physicians contribute their expertise and knowledge regarding the latest cutting-edge developments in the field of spine surgery. Trends discussed in this issue include the various ways in which the changing financial aspects and models of spine surgery are affecting the care delivered to patients.

Focused Issue on Cancer Metastasis: Molecular Signaling and Therapeutic

This Focused Issue on “Cancer Metastasis: Molecular Signaling and Therapeutic” is edited by Dr. Khalid Sossey-Alaoui, PhD, from Division of Cancer Biology, MetroHealth Medical Research Center, MetroHealth System, Cleveland, Ohio, USA.

ATM Annual Report 2019

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2020. 2019 has seen much progress for the journal:
- The first Impact Factor for ATM: 3.689
- More than 1000 papers have been published in ATM in 2019
- The retrieval of ATM in PubMed increased rapidly with a total of 2, 372, 977 times in 2019.
- The number of total citations by SCI journals has significantly increased to 11,592 until Dec. 2019
- The pageviews of ATM is increasing significantly, with a total of 1,034,942 hits in 2019.

ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

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Vol 8, No 3 (February, 2020)

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Meet The Professor more

Professor Warren Boling: please be passionate about everything you do More >>

Professor Prithvi Mruthyunjaya: working together to move the field forward and better help our... More >>

Professor Seema Nagpal: which one should be given the priority, radiation or drug? More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article on Lung Transplantation

The value of high-resolution HLA in the perioperative period of non-sensitized lung transplant recipients

Ji Zhang, Dong Liu, Caixin Zhang, Min Zhou, Jian Lv, Hongmei Wang, Hang Yang, Li Fan, Bo Wu, Jingyu Chen

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Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage

Dong Wei, Fei Gao, Zhenkun Yang, Wei Wang, Yinglun Chen, Yan Lu, Jingyu Chen

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Clinical outcomes of ceftazidime-avibactam in lung transplant recipients with infections caused by extensively drug-resistant gram-negative bacilli

Wenhui Chen, Lingxiao Sun, Lijuan Guo, Bin Cao, Yingmei Liu, Li Zhao, Binghuai Lu, Binbin Li, Jingyu Chen, Chen Wang

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Can the preoperative nutritional risk score be a predictor of the outcomes in critically ill patients of lung transplantation: a retrospective study

Kongmiao Lu, Huixing Li, Yinglun Chen, Bo Wu, Ji Zhang, Man Huang, Jingyu Chen

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Review Article on Lung Transplantation

China lung transplantation developing: past, present and future

Bo Wu, Chunxiao Hu, Wenhui Chen, Jianxing He, Gening Jiang, Ji Zhang, Dong Liu, Xiaoshan Li, Dong Wei, Guohui Jiao, Chen Wang, Jingyu Chen

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Editorial on Lung Transplantation

Extended ex vivo lung perfusion—abridged expense

Harpreet Singh Grewal, Atul C. Mehta, Alejandro Bribiesco

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Is perfusate exchange during ex vivo lung perfusion beneficial?

Christina C. Kao, Amit D. Parulekar

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Nutritional status and lung transplantation: an intriguing problem

Mario Nosotti, Michele Ferrari

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HLA typing in lung transplantation: does high resolution fit all?

Silvia Deaglio, Antonio Amoroso, Mauro Rinaldi, Massimo Boffini

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High-resolution human leukocyte antigen typing and early post-transplant outcomes: more than meets the eye

Annelore Sacreas, Stijn E. Verleden

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Consensus

Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Laishuan Wang, Yuan Shi, Tiantian Xiao, Jianhua Fu, Xing Feng, Dezhi Mu, Qi Feng, Mingyan Hei, Xiaojing Hu, Zhankui Li, Guoping Lu, Zezhong Tang, Yajuan Wang, Chuanqing Wang, Shiwen Xia, Jianqing Xu, Yujia Yang, Jie Yang, Mei Zeng, Jun Zheng, Wei Zhou, Xiaoyu Zhou, Xiaoguang Zhou, Lizhong Du, Shoo K. Lee, Wenhao Zhou, on behalf of the Working Committee on Perinatal, and Neonatal Management for the Prevention and Control of the 2019 Novel Coronavirus Infection

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Column in Laboratory Medicine

Which lessons shall we learn from the 2019 novel coronavirus outbreak?

Camilla Mattiuzzi, Giuseppe Lippi

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Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Big-data Clinical Trial Column

Propensity score analysis for time-dependent exposure

Zhongheng Zhang, Xiuyang Li, Xiao Wu, Huixian Qiu, Hongying Shi, written on behalf of AME Big-Data Clinical Trial Collaborative Group

Case Report

Rare paradoxical adverse event in Crohn’s disease: a case report

Marina Okoshi, Hiroki Sato, Terasu Honma, Shuji Terai

Localized bullous pemphigoid: a case report

Yiman Wang, Xuming Mao, Yangchun Liu, Li Li

Editorial

A new peg-filgrastim biosimilar, mecapegfilgrastim for primary prophylaxis of chemotherapy-related neutropenia is now available

Umberto Tirelli, Antonino Carbone, Raffaele Di Francia, Massimiliano Berretta

TSPAN8 and distant metastasis of nasopharyngeal carcinoma cells

Changqing Xie, Nicole A. McGrath

Real-life clinical data mining: generating hypotheses for evidence-based medicine

Jean-Emmanuel Bibault

Joint forces for making clinical prediction models contribute to science

Junfeng Wang, Yue Li

Predictive analytics in the era of big data: opportunities and challenges

Zhongheng Zhang

Symptomatic late-onset hypogonadism but normal total testosterone: the importance of testosterone annual decrease velocity

Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Laura M. Mongioì, Ylenia Duca, Laura Cimino, Filippo Giacone, Antonio Aversa

Prolonged follow-up of colorectal cancer patients after 5 years: to follow or not to follow, that is the question (and how)!

Raul Caso, Anne Fabrizio, Michael Sosin

Minimally invasive mitral valve surgery to maximally benefit patients—what is the key to success today and tomorrow?

Moritz C. Wyler von Ballmoos

Clinical prediction model construction and evaluation: a challenge for clinical researchers

Qiu-Yan Han, Zhi-De Hu

Can transrectal ultrasound-guided core needle biopsy serve as an accurate diagnostic tool for rectal lesions?

Dong Hoon Baek, Gwang Ha Kim

Clinical prediction models: evaluation matters

Hong-Qiu Gu, Chelsea Liu

Combining old and new strategies for colorectal cancer screening

Elisa Danese, Martina Montagnana, Giuseppe Lippi

Overview of clinical prediction models

Lingxiao Chen

Mitochondrial solar sensitivity: evolutionary and biomedical implications

Andrei P. Sommer

Statistical methods and models in the analysis of time to event data

Minjung Lee, Junhee Han

Comparison between muscle-preserving selective laminectomy and laminoplasty for multilevel cervical spondylotic myelopathy

Satoshi Nori, Tateru Shiraishi, Ryoma Aoyama

Maintaining anorectal function in patients with rectal cancer using biofeedback training

Andrea M. Stringer

Necessity of guidelines for publication of patient-derived cancer models

Tadashi Kondo

Can human placental extract help patients with osteoarthritis?

Nequesha S. Mohamed, Wayne A. Wilkie, Ethan A. Remily, Ronald E. Delanois

Mind body medicine: a tangible link between the gut and the brain

Luis Vitetta

Models and prediction, how and what?

Yujing Xie, Zhangsheng Yu

Targeting the mitogen-activated protein kinase-mediated vascular smooth muscle cell remodeling by angiotensin II

Masanori Yoshizumi, Yoji Kyotani, Jing Zhao, Kiichi Nakahira

How to use statistical models and methods for clinical prediction

Giuliana Cortese

A role for Follistatin-like protein 1 (FSTL1) in colorectal cancer

Ioannis A. Voutsadakis

Role of echocardiography in sepsis and septic shock

Saraschandra Vallabhajosyula, Abdelrahman M. Ahmed, Pranathi R. Sundaragiri

Structural heart disease: the revolution

Daniel Hernandez-Vaquero

Human placental extract: the feasibility of translation from basic science into clinical practice

Ahmed K. Emara, Hiba Anis, Nicolas S. Piuzzi

MLKL-dependent epithelial-to-mesenchymal transition in nasopharyngeal carcinoma: a novel finding and avenues for future research

Tristan Tham

A nomogram with enhanced function facilitated by nomogramEx and nomogramFormula

Guoshu Bi, Runmei Li, Jiaqi Liang, Zhengyang Hu, Cheng Zhan

The power of clinical data empowered by clinical prediction model: an R tutorial

Lutao Dai, Dan Yang, Haipeng Shen

Bariatric surgery focused issue

Muhammed Ashraf Memon

The efficacy of polyp detection and tumor characterization of blue laser imaging, blue light imaging, and linked color imaging with light-emitted diode (LED) and LASER endoscope

Naohisa Yoshida, Osamu Dohi, Ken Inoue, Yoshito Itoh

Editorial Commentary

Application of novel nanotechnologies in asthma

Adriana Lopes da Silva, Luisa Andrade Silva, Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Marcelo Marcos Morales

Predicting fluid responsiveness with the passive leg raising test: don’t be fooled by intra-abdominal hypertension!

Andrea Minini, Paul Abraham, Manu L. N. G. Malbrain

The passive leg raising under pressure: focus on the impact of intra-abdominal hypertension

Victor Beaucoté, Guillaume Geri, Antoine Vieillard-Baron

Periprocedural anticoagulation in non-ST-segment elevation acute coronary syndrome: time to reassess?

Rishi Chandiramani, Davide Cao, Roxana Mehran

Impact of renal impairment on light chain amyloidosis outcomes after autologous hematopoietic stem cell transplantation

Samer A. Srour, Muzaffar H. Qazilbash

Correlation between corticosteroid injections and surgical site infections in shoulder arthroscopy

Riccardo Compagnoni, Pietro Randelli

Unicompartmental knee arthroplasty over total knee arthroplasty: a more cost-effective strategy for treating medial compartment arthritis

Samuel W. Carlson, Rafael J. Sierra

Cost of cardiovascular disease prevention: towards economic evaluations in prevention programs

João Vasco Santos, Désirée Vandenberghe, Mariana Lobo, Alberto Freitas

Microcirculation and mean arterial pressure: friends or foes?

Olfa Hamzaoui, Rui Shi

The recent failure of the PROMESA clinical trial for multiple system atrophy raises the question—are polyphenols a viable therapeutic option against proteinopathies?

Gal Bitan

The Chinese experience with anti-NMDAR encephalitis

Virginie Desestret

FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways

Cara A. Rabik, Jiawan Wang, Christine A. Pratilas

Keynote 42: Pembrolizumab, PD-L1, and where to draw the line

James Isaacs, Jeffrey Clarke, Neal Ready

Beyond finding druggable targets and tumor mutational burden: to measure heterogeneity by ctDNA

Zhichao Liu, Jianxing He, Wenhua Liang

When data interpretation should not rely on the magnitude of P values: the example of ANDROMEDA SHOCK trial

Francesco Corradi, Guido Tavazzi, Gregorio Santori, Francesco Forfori

To combine or not to combine: anti-vascular endothelial growth factor therapies in EGFR mutation positive non-small cell lung cancer

Hidehito Horinouchi

Medial femorotibial osteoarthritis of the knee: total or partial knee replacement?

Jean-Noel A. Argenson, Christophe Jacquet, Matthieu Ollivier

Addressing the challenge to identify the role played by lifestyle factors in dementia

Tasnime Akbaraly

The Bayesian approach: may we learn a lesson from the ANDROMEDA-SHOCK trial?

Federico Franchi, Cesare Biuzzi, Emanuele Detti, Gabriele Cevenini, Sabino Scolletta

Interpretation or misinterpretation of clinical trials on septic shock: about the ANDROMEDA-SHOCK trial

François Dépret, Maxime Coutrot

Rotator cuff muscle stem cells: the double-edged sword in the skeletal muscle

Yong-Soo Lee, Ja-Yeon Kim, Seok Won Chung

Letter to the Editor

Von Hippel-Lindau: implications in development and disease—response

Kasey R. Cargill, Sunder Sims-Lucas

Platelet-derived HMGB1: critical mediator of SARs related to transfusion

Fabrice Cognasse, Caroline Sut, Hind Hamzeh-Cognasse, Olivier Garraud

Renal double negative T cells: increasing importance in health and disease

Mohanraj Sadasivam, Sanjeev Noel, Hamid Rabb, Abdel Rahim A. Hamad

Pan-cancer analysis of KEAP1 mutations as biomarkers for immunotherapy outcomes

Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou, Tao Jiang

Translating artificial intelligence into clinical practice

Duoru Lin, Haotian Lin

Below safety limits, every unit of glomerular filtration rate counts—reply letter

Carlotta Palumbo, Alessandro Antonelli

Cumulative antibiotic use significantly decreases efficacy of checkpoint inhibitors in patients with advanced cancer—reply to the editors

Nadina Tinsley, Donna M. Graham, Natalie Cook

A novel intrauterine stent for prevention of intrauterine adhesions

Huan Huang, Bin Xu, Chunxia Cheng, Dabao Xu

Why acute kidney injury during partial nephrectomy matters

Carlo A. Bravi, Andrew Vickers

Top-down proteomics—a near-future technique for clinical diagnosis?

Lidong He, Alan L. Rockwood, Archana M. Agarwal, Lissa C. Anderson, Chad R. Weisbrod, Christopher L. Hendrickson, Alan G. Marshall

ProBNP processing is decreased by obesity in patients with heart failure

Lynley K. Lewis, Sara D. Raudsepp, Tim C. R. Prickett, Tim G. Yandle, Chris J. Pemberton, A. Mark Richards

Prophylaxis of breast cancer chemotherapy for bone marrow toxicity: more individualized and safer

Fengrui Xu, Zefei Jiang

Optimized clinical randomized controlled trials designed for biomarker-guided antibiotics stewardship

Wensen Chen, Kai Zhang, Yun Liu

Circular RNAs as non-invasive urinary biomarker of kidney diseases

Malte Kölling, Johan M. Lorenzen

The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation

Katherine J. Donohue, Matthew S. Gentry, Ramon C. Sun

The role of CT for Covid-19 patient’s management remains poorly defined

Yi Xiang J. Wang, Wei-Hong Liu, Mo Yang, Wei Chen

CT imaging of coronavirus disease 2019 (COVID-19): from the qualitative to quantitative

Xiaolong Qi, Junqiang Lei, Qian Yu, Yarong Xi, Yuancheng Wang, Shenghong Ju

Meet the Professor

Prof. Leif Rogers: the recent advances in implant breast reconstruction and fat grafting

Karina Yang, Angelia Zhou

Prof. Helen Feltovich: today it’s 5G, tomorrow it’s 100G, who knows what can happen?

Jessie Bu, Angelia Zhou

Ren Zhao: no standard answer to be a doctor

Siying Yan, Chen Gao

Xiaohong Fan: breaking up “routine practices”

Siying Yan

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Net benefit of routine urine parameters for urinary tract infection screening: a decision curve analysis

Yan-Qiu Han, Lei Zhang, Jun-Rui Wang, Shang-Cheng Xu, Zhi-De Hu

An artificial intelligent platform for live cell identification and the detection of cross-contamination

Ruixin Wang, Dongni Wang, Dekai Kang, Xusen Guo, Chong Guo, Meimei Dongye, Yi Zhu, Chuan Chen, Xiayin Zhang, Erping Long, Xiaohang Wu, Zhenzhen Liu, Duoru Lin, Jinghui Wang, Kai Huang, Haotian Lin

Translational aspects of body image research for obesity-related quality of life and weight loss maintenance post-bariatric surgery

Marie L. Caltabiano

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry combined with UF-5000i urine flow cytometry to directly identify pathogens in clinical urine specimens within 1 hour

Chuang Sun, Xiao Zhang, Jingqiao Wang, Chen Cheng, Haiquan Kang, Bing Gu, Ping Ma

Logistic regression analyses of factors affecting fertility of intrauterine adhesions patients

Xingping Zhao, Yunzhi Liu, Aiqian Zhang, Bingsi Gao, Qing Feng, Huan Huang, Xiuting Zhu, Xin Sun, Dabao Xu

Obstetrical outcome in the third trimester after hysteroscopic adhesiolysis

Qing Feng, Bingsi Gao, Huan Huang, Jeffrey Je-Chuen Woo, Lingxiao Zou, Xingping Zhao, Chunxia Cheng, Dabao Xu

Study on the correlation among dysbacteriosis, imbalance of cytokine and the formation of intrauterine adhesion

Xingping Zhao, Qun Zhao, Xiuting Zhu, Huan Huang, Xing Wan, Rui Guo, Yanqiu Zhao, Dan Chen, Dabao Xu

Cold scissors ploughing technique in hysteroscopic adhesiolysis: a comparative study

Xingping Zhao, Aiqian Zhang, Bingsi Gao, Burjoo Arvind, Huan Huang, Dabao Xu

Building radiation-resistant model in triple-negative breast cancer to screen radioresistance-related molecular markers

Zhi-Rui Zhou, Xuan-Yi Wang, Xiao-Li Yu, Xin Mei, Xing-Xing Chen, Qun-Chao Hu, Zhao-Zhi Yang, Xiao-Mao Guo

Artificial intelligence-tutoring problem-based learning in ophthalmology clerkship

Dongxuan Wu, Yifan Xiang, Xiaohang Wu, Tongyong Yu, Xiucheng Huang, Yuxian Zou, Zhenzhen Liu, Haotian Lin

Automatic identification of myopia based on ocular appearance images using deep learning

Yahan Yang, Ruiyang Li, Duoru Lin, Xiayin Zhang, Wangting Li, Jinghui Wang, Chong Guo, Jianyin Li, Chuan Chen, Yi Zhu, Lanqin Zhao, Haotian Lin

The factors contributing to cognitive dysfunction in type 2 diabetic patients

San-Shan Xia, Wen-Lin Xia, Jiao-Jiao Huang, Hua-Jie Zou, Jing Tao, Yan Yang

Association between genetic risk scores and risk of narcolepsy: a case-control study

Hui Ouyang, Fang Han, Zechen Zhou, Qiwen Zheng, Yangyang Wang, Jun Zhang

Web-based study on Chinese dermatologists’ attitudes towards artificial intelligence

Changbing Shen, Chengxu Li, Feng Xu, Ziyi Wang, Xue Shen, Jing Gao, Randy Ko, Yan Jing, Xiaofeng Tang, Ruixing Yu, Junhu Guo, Feng Xu, Rusong Meng, Yong Cui

Growth hormone promotes human endometrial glandular cells proliferation and motion through the GHR-STAT3/5 pathway

Qing Feng, Bingsi Gao, Huan Huang, Lingxiao Zou, Xingping Zhao, Xiuting Zhu, Dabao Xu

Research of the potential biomarkers in vaginal microbiome for persistent high-risk human papillomavirus infection

Xiaopei Chao, Tingting Sun, Shu Wang, Xianjie Tan, Qingbo Fan, Honghui Shi, Lan Zhu, Jinghe Lang

Class A1 scavenger receptors mediated macrophages in impaired intestinal barrier of inflammatory bowel disease

Chenxi Xie, Yanyun Fan, Yinshi Huang, Shuangting Wu, Haimei Xu, Lupeng Liu, Yiqun Hu, Qingwen Huang, Huaxiu Shi, Lin Wang, Hongzhi Xu, Jingling Su, Jianlin Ren

The predictive value of baseline hepatic venous pressure gradient for variceal rebleeding in cirrhotic patients receiving secondary prevention

Chuan Liu, Yanna Liu, Ruoyang Shao, Sining Wang, Guangchuan Wang, Lifen Wang, Mingyan Zhang, Jinlin Hou, Chunqing Zhang, Xiaolong Qi

Prognosis and risk factors for the development of pulmonary metastases after preoperative chemoradiotherapy and radical resection in patients with locally advanced rectal cancer

Weihao Li, Jianhong Peng, Cong Li, Lifang Yuan, Wenhua Fan, Zhizhong Pan, Xiaojun Wu, Junzhong Lin

Initial anticoagulation experience with standard-dose rivaroxaban after Watchman left atrial appendage occlusion

Zhi-Chun Gu, Zhi-Qing Qiao, Zi-Yong Hao, Zheng Li, Li-Sheng Jiang, Heng Ge, Ben He, Jun Pu

Preoperative prediction of hepatocellular carcinoma with highly aggressive characteristics using quantitative parameters derived from hepatobiliary phase MR images

Zheng Ye, Likun Cao, Yi Wei, Jie Chen, Zhen Zhang, Shan Yao, Ting Duan, Bin Song

Blockade of OX40/OX40L pathway combined with ethylene-carbodiimide-fixed donor splenocytes induces donor-specific allograft tolerance in presensitized recipients

Xingqiang Lai, Zhongpeng Yao, Fen Ning, Lei Zhang, Jiali Fang, Guanghui Li, Lu Xu, Yunyi Xiong, Luhao Liu, Rongxin Chen, Junjie Ma, Zheng Chen

Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression

Wei He, Kaiming Yuan, Bin Ji, Yuan Han, Jun Li

Direct versus conventional anticoagulants for treatment of cancer associated thrombosis: a pooled and interaction analysis between observational studies and randomized clinical trials

Zhi-Chun Gu, Yi-Dan Yan, Sheng-Yan Yang, Long Shen, Ling-Cong Kong, Chi Zhang, An-Hua Wei, Zheng Li, Xin-Hua Wang, Hou-Wen Lin

Liver resection is beneficial for patients with colorectal liver metastases and extrahepatic disease

Kristina Hasselgren, Bengt Isaksson, Bjarne Ardnor, Gert Lindell, Magnus Rizell, Cecilia Strömberg, Per Loftås, Bergthor Björnsson, Per Sandström

Effects of collimated and focused low-intensity pulsed ultrasound stimulation on the mandible repair in rabbits

Xiaohan Liu, Ying Hu, Lin Wu, Shujun Li

Establishing M1 stage subdivisions by incorporating radiological features and Epstein-Barr virus DNA for metastatic nasopharyngeal carcinoma

Wei-Hong Zheng, Xiao-Jun He, Fo-Ping Chen, Li Lin, Xiao-Dan Huang, Hua-Qiang Zhou, Jia Kou, Jia-Wei Lv, Jun Ma, Guan-Qun Zhou, Ying Sun

Scientometric analysis of mTOR signaling pathway in liver disease

Jing Fang, Long Pan, Qiu-Xia Gu, Sarun Juengpanich, Jun-Hao Zheng, Chen-Hao Tong, Zi-Yuan Wang, Jun-Jie Nan, Yi-Fan Wang

Development and validation of an individualized gene expression-based signature to predict overall survival in metastatic colorectal cancer

Shu-Biao Ye, Yi-Kan Cheng, Jian-Cong Hu, Feng Gao, Ping Lan

Surgical fixation of rib fractures decreases intensive care length of stay in flail chest patients

Xiangzhi Xiao, Shengchao Zhang, Juhua Yang, Jian Wang, Zhilong Zhang, Hao Chen

Three-dimensional printing flexible models: a novel technique for Nuss procedure planning of pectus excavatum repair

Lei Wang, Ting Guo, Hao Zhang, Sanhu Yang, Jiahe Liang, Yitong Guo, Qiuya Shao, Tiesheng Cao, Xiaofei Li, Lijun Huang

Low expression of A-kinase anchor protein 5 predicts poor prognosis in non-mucin producing stomach adenocarcinoma based on TCGA data

Zishao Zhong, Zhenhao Ye, Guihua He, Wang Zhang, Jing Wang, Suiping Huang

The role of preoperative 3D-ultrasound in intraoperative judgement for hysteroscopic adhesiolysis

Arvind Burjoo, Xingping Zhao, Lingxiao Zou, Xinyi Liu, Baiyun Zhang, Dabao Xu

Identification and analysis of dysregulated lncRNA and associated ceRNA in the pathogenesis of keloid

Xilei Duan, Yuemeng Wu, Zheng Zhang, Zhong Lu

Study on the antibacterial activities of emodin derivatives against clinical drug-resistant bacterial strains and their interaction with proteins

Chengjie Ji, Guang Xin, Feixia Duan, Wen Huang, Taichang Tan

Clinical significance and prognosis of supraclavicular lymph node metastasis in patients with thoracic esophageal cancer

Fudong Wang, Xiaosong Ge, Zhiqiang Wang, Yuan Weng, Rong Yin, Qingjun You

Identification of hub genes and potential molecular mechanisms of chickpea isoflavones on MCF-7 breast cancer cells by integrated bioinformatics analysis

Jia Wang, Hao Yu, Abulimit Yili, Yanhua Gao, Linlin Hao, Haji Akber Aisa, Songcai Liu

ALDH2 rs671 polymorphisms and the risk of cerebral microbleeds in Chinese elderly: the Taizhou Imaging Study

Zhen Zhu, Yanfeng Jiang, Mei Cui, Yingzhe Wang, Shuyuan Li, Kelin Xu, Kexun Zhang, Chengkai Zhu, Wanghong Xu, Li Jin, Weimin Ye, Chen Suo, Xingdong Chen

Distinguishing risk factors between congenital anophthalmia and microphthalmia using multivariable logistic regression

Yang Li, Zhijia Hou, Jingwen Ding, Ying Cui, Bixuan Qin, Dongmei Li

Rapid identification of pathogens involved in pediatric osteoarticular infections by multiplex PCR

Chi Gan, Jinfeng Hu, Qing Cao, Ruike Zhao, Yuchan Li, Zhigang Wang, Yue Tao, Xi Mo

Fentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/Akt signaling pathway

Chunlai Li, Yi Qin, Yu Zhong, Yinying Qin, Yi Wei, Li Li, Yubo Xie

An intronic polymorphism of NFATC1 gene shows a risk association with biopsy-proven acute rejection in renal transplant recipients

Zijie Wang, Hengcheng Zhang, Haiwei Yang, Ming Zheng, Miao Guo, Hao Chen, Li Sun, Zhijian Han, Jun Tao, Xiaobing Ju, Ruoyun Tan, Ji-Fu Wei, Min Gu

Sirolimus-based immunosuppression improves outcomes in liver transplantation recipients with hepatocellular carcinoma beyond the Hangzhou criteria

Sunbin Ling, Tingting Feng, Qifan Zhan, Xin Duan, Guangjiang Jiang, Tian Shen, Qiaonan Shan, Shengjun Xu, Qianwei Ye, Peng Liu, Beini Cen, Shusen Zheng, Xiao Xu

Forkhead box K1 regulates the malignant behavior of gastric cancer by inhibiting autophagy

Yixuan Wang, Wensheng Qiu, Ning Liu, Libin Sun, Zhao Liu, Shasha Wang, Peng Wang, Shihai Liu, Jing Lv

Mortality and chronic obstructive pulmonary disease in patients treated with endovascular revascularization of the infra-inguinal lower limb arteries from retrograde access

Zoltan Ruzsa, Rafał Januszek, Viktor Óriás, Michał Chyrchel, Joanna Wojtasik-Bakalarz, Jerzy Bartuś, Saleh Arif, Paweł Kleczyński, Tomasz Tokarek, Andras Nyerges, Agata Stanek, Dariusz Dudek, Stanisław Bartuś

Transanal versus nontransanal surgery for the treatment of primary rectal gastrointestinal stromal tumors: a 10-year experience in a high-volume center

Zifeng Yang, Wentai Guo, Rongkang Huang, Minhui Hu, Huaiming Wang, Hui Wang

Prognostic value of nasopharynx tumour volume in local-regional advanced nasopharyngeal carcinoma

Weiqiong Ni, Weixiang Qi, Fei Xu, Weiguo Cao, Cheng Xu, Jiayi Chen, Yunsheng Gao

Differentiation combined hepatocellular and cholangiocarcinoma from intrahepatic cholangiocarcinoma based on radiomics machine learning

Jun Zhang, Zixing Huang, Likun Cao, Zhen Zhang, Yi Wei, Xin Zhang, Bin Song

Impact of the use of vasoactive drugs in cardiac death donors on the early postoperative renal function and related complications in renal transplant recipients

Peng Zhang, Peihua Cao, Jiali Fang, Guanghui Li, Lei Zhang, Lu Xu, Shijing Mo, Xingqiang Lai, Luhao Liu, Yunyi Xiong, Wei Yin, Li Li, Rongxin Chen, Hailin Xu, Tao Zhang, Jiao Wan, Yuhe Guo, Junjie Ma, Zheng Chen

Multiparametric radiomics nomogram may be used for predicting the severity of esophageal varices in cirrhotic patients

Shang Wan, Yi Wei, Xin Zhang, Xijiao Liu, Weiwei Zhang, Yuhao He, Fang Yuan, Shan Yao, Yufeng Yue, Bin Song

Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways

Qunyan Yao, Shuyu Li, Xinlai Cheng, Yanting Zou, Yue Shen, Shuncai Zhang

External validation of the eighth edition of the TNM classification for lung cancer in 3,611 surgically treated patients at a single institution

Jia Wang, Nan Wu, Chao Lv, Yue Yang

Association of survival and genomic mutation signature with immunotherapy in patients with hepatocellular carcinoma

Qiyun Ou, Yunfang Yu, Anlin Li, Jie Chen, Tingting Yu, Xiaolin Xu, Xinxin Xie, Yongjian Chen, Dagui Lin, Qiaohong Zeng, Yuxin Zhang, Xudong Tang, Herui Yao, Baoming Luo

Machine learning for the prediction of severe pneumonia during posttransplant hospitalization in recipients of a deceased-donor kidney transplant

You Luo, Zuofu Tang, Xiao Hu, Shuo Lu, Bin Miao, Songlin Hong, Haiyun Bai, Chen Sun, Jiang Qiu, Huiying Liang, Ning Na

Elevated lipid levels in patients with achilles tendon ruptures: a retrospective matching study

Yu-Ping Yang, Li-Yuan Tao, Jia-Ning Gao, Peng Wang, Yan-Fang Jiang, Le-Min Zheng, Yi-Ming Zhao, Ying-Fang Ao

Novel prognostic nomograms for female patients with breast cancer and bone metastasis at presentation

Zhan Wang, Yonggang Cheng, Shi Chen, Haiyu Shao, Xiaowei Chen, Zenan Wang, Yucheng Wang, Hao Zhou, Tao Chen, Nong Lin, Zhaoming Ye

Multiclassifier fusion based on radiomics features for the prediction of benign and malignant primary pulmonary solid nodules

Yao Shen, Fangyi Xu, Wenchao Zhu, Hongjie Hu, Ting Chen, Qiang Li

Serum PON1 as a biomarker for the estimation of microvascular invasion in hepatocellular carcinoma

Guang-Yu Ding, Xiao-Dong Zhu, Yuan Ji, Guo-Ming Shi, Ying-Hao Shen, Jian Zhou, Jia Fan, Hui-Chuan Sun, Cheng Huang

Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, Bombyx mori

Jiang-Bo Song, Kai-Ge Hao, Xin Chen, Yan-Hua Zhang, Zi-Lin Cheng, Shuang Mao, Yong-Xi Tang, Xiao-Ling Tong, Fang-Yin Dai

PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating I_Ks and I_CaL—insights from human atrial modelling

Jieyun Bai, Yaosheng Lu, Andy Lo, Jichao Zhao, Henggui Zhang

Health status of middle-aged and older cancer survivors: a nationwide cross-sectional study from the China Health and Retirement Longitudinal Study (CHARLS)

Jiarui Li, Haiyu Pang, Zhao Sun, Lin Zhao, Chunmei Bai

Deep learning LI-RADS grading system based on contrast enhanced multiphase MRI for differentiation between LR-3 and LR-4/LR-5 liver tumors

Yunan Wu, Gregory M. White, Tyler Cornelius, Indraneel Gowdar, Mohammad H. Ansari, Mark P. Supanich, Jie Deng

A survey of primary care physician referral to bariatric surgery in Manitoba: access, perceptions and barriers

Mostafa El-Beheiry, Ashley Vergis, Jung-Un Choi, Kathleen Clouston, Krista Hardy

The combination of preoperative D-dimer and CA19-9 predicts lymph node metastasis and survival in intrahepatic cholangiocarcinoma patients after curative resection

Qichen Chen, Yiling Zheng, Hong Zhao, Jianqiang Cai, Liming Wang, Jianjun Zhao, Xinyu Bi, Zhiyu Li, Zhen Huang, Yefan Zhang, Jianguo Zhou, Jianxiong Wu

Benefits of adjuvant treatment including trastuzumab in HER2-positive pT1a-bN0M0 breast cancer: a systematic review and meta-analysis

Hye Yoon Lee, In-Soo Shin, Chai Hong Rim

Infections and risk of end-stage renal disease in patients with nephrotic syndrome: a nationwide population-based case-control study

Chien-Hung Lin, Peir-Haur Hung, Wen-Sheng Liu, Hsiao-Yun Hu, Chi-Jung Chung, Tsung-Hsien Chen

Clinical characteristics of perivascular space and brain CT perfusion in stroke-free patients with intracranial and extracranial atherosclerosis of different extents

Hui Wang, Zhi-Yu Nie, Meng Liu, Ren-Ren Li, Li-He Huang, Zheng Lu, Ling-Jing Jin, Yun-Xia Li

Red blood cell distribution width is associated with mortality after acute ischemic stroke: a cohort study and systematic review

Lu Wang, Changyi Wang, Simiao Wu, Yuxiao Li, Wen Guo, Ming Liu

Transcriptomic changes and potential regulatory mechanism of intrauterine human chorionic gonadotropin (hCG) co-cultured with peripheral blood mononuclear cells (PBMCs) infusion in mice with embryonic implantation dysfunction

Jiao Chen, Xuehan Zhao, Liangfei Ao, Tailang Yin, Jing Yang

A preliminary study on a patented intrauterine stent in the treatment of recurrent intrauterine adhesions with poor prognosis

Huan Huang, Lingxiao Zou, Aiqian Zhang, Xingping Zhao, Dabao Xu, Min Xue

Recommended changes for the 8th edition of the TNM classification for lung cancer-the findings of a single-institution evaluation

Jia Wang, Nan Wu, Chao Lv, Shi Yan, Yue Yang

Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis

Xi Zhang, Zonglin Dai, Eric H. Y. Lau, Chunping Cui, He Lin, Jun Qi, Weifeng Ni, Like Zhao, Qing Lv, Jieruo Gu, Zhiming Lin

High-resolution combined arterial spin labeling MR for identifying cerebral arterial stenosis induced by moyamoya disease or atherosclerosis

Jingyuan Ya, Da Zhou, Jiayue Ding, Yuchuan Ding, Xunming Ji, Qi Yang, Ran Meng

Polymyositis/dermatomyositis is a potential risk factor for acute respiratory failure: a pulmonary heart disease

Shih-Huei Syue, Yi-Hua Chang, Pei-Ju Shih, Cheng-Li Lin, Jun-Jun Yeh, Chia-Hung Kao

Association between IL-1beta and cardiovascular disease risk in patients with newly diagnosed, drug-naïve type 2 diabetes mellitus: a cross-sectional study

Kyong Hye Joung, Ji Min Kim, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku

Efficacy of Ca²⁺- or PO4³⁻-conjugated mesoporous silica nanoparticles on dentinal tubule occlusion: an in-vitro assessment

Tianjia Yu, Yu Wang, Qiang Cai, Lin Wu

Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells

Zhixia Dong, Qian Zhuang, Min Ning, Shan Wu, Lungen Lu, Xinjian Wan

Pilot study: deficiency of mannose-binding lectin-dependent lectin pathway, a novel modulator in outcome from pancreatic islet auto-transplantation

Wen Yuan Chung, Cristina A. Pollard, Cordula Stover, Bashoo Naziruddin, Rohan Kumar, John Isherwood, Eyad Issa, Marlon F. Levy, Giuseppe Garcea, Ashley R. Dennison

Clinical characteristics and neuroimaging findings in eagle syndrome induced internal jugular vein stenosis

Chaobo Bai, Zhongao Wang, Jingwei Guan, Kexin Jin, Yuchuan Ding, Xunming Ji, Ran Meng

PITPNC1 fuels radioresistance of rectal cancer by inhibiting reactive oxygen species production

Yujing Tan, Ruoyang Shao, Jingyu Li, Hongyun Huang, Yanru Wang, Menglan Zhang, Jianyun Cao, Junde Zhang, Junguo Bu

Diagnosis and treatment of cervical incompetence combined with intrauterine adhesions

Waixing Li, Yueran Li, Xingping Zhao, Chunxia Cheng, Arvind Burjoo, Yimin Yang, Dabao Xu

Establishment of an animal model of intrauterine adhesions after surgical abortion and curettage in pregnant rats

Qing Feng, Bingsi Gao, Xingping Zhao, Huan Huang, Shuijing Yi, Lingxiao Zou, Xinyi Liu, Min Xue, Dabao Xu

A novel topoisomerase I inhibitor DIA-001 induces DNA damage mediated cell cycle arrest and apoptosis in cancer cell

Jiaqi Liu, Guohe Geng, Guang Liang, Ling Wang, Kuntian Luo, Jian Yuan, Shiguang Zhao

A two-circular RNA signature of donor circFOXN2 and circNECTIN3 predicts early allograft dysfunction after liver transplantation

Kun Wang, Xuyong Wei, Qiang Wei, Di Lu, Wangyao Li, Binhua Pan, Junli Chen, Haiyang Xie, Shusen Zheng, Xiao Xu

Effects of the different-sized external stents on vein graft intimal hyperplasia and inflammation

Qi Yang, Dong Lei, Shixing Huang, Yi Yang, Yang Yang, Xiaofeng Ye, Zhengwei You, Qiang Zhao

Prognostic value of chronic hepatitis B virus infection in patients with breast cancer in a hepatitis B virus endemic area

Weikai Xiao, Ying Zhou, Ping Yu, Anli Yang, Shaoquan Zheng, Hailin Tang, Xiaoming Xie

Myeloid derived suppressor cells are reduced and T regulatory cells stabilised in patients with advanced pancreatic cancer treated with gemcitabine and intravenous omega 3

John Isherwood, Ali Arshad, Wen Yuan Chung, Franscois Runau, Jill Cooke, Cristina Pollard, Lynne Howells, Jenny Fishwick, John Thompson, Matthew Metcalfe, William Steward, Ashley Dennison

Early removal of chest tubes leads to better short-term outcome after video-assisted thoracoscopic surgery lung resection

Tuo Xing, Xukai Li, Jun Liu, Ying Huang, Shilong Wu, Minzhang Guo, Hengrui Liang, Jianxing He

Non-invasive urinary sediment double-immunostaining predicts BK polyomavirus associated-nephropathy in kidney transplant recipients

Xu-Tao Chen, Wen-Fang Chen, Xiao-Tao Hou, Shi-Cong Yang, Hui-Fei Yang, Jun Li, Rong-Hai Deng, Yang Huang, Yelidana Nuertai, Chang-Xi Wang, Jiang Qiu, Gang Huang

Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis

Shu Yang, Peihua Cao, Peipei Du, Ziting Wu, Zian Zhuang, Lin Yang, Xuan Yu, Qi Zhou, Xixi Feng, Xiaohui Wang, Weiguo Li, Enmei Liu, Ju Chen, Yaolong Chen, Daihai He, on behalf of COVID-19 evidence and recommendations working group

Ginsenoside Rg1 prevents early diabetic retinopathy via reducing retinal ganglion cell layer and inner nuclear layer cell apoptosis in db/db mice

Ye Gao, Yubin Ji, Yun Luo, Jiafu Sun, Guibo Sun, Xiaobo Sun

Cyclic helix B peptide ameliorates renal tubulointerstitial fibrosis induced by unilateral ureter obstruction via inhibiting NLRP3 pathway

Ruochen Qi, Weitao Zhang, Long Zheng, Ming Xu, Ruiming Rong, Tongyu Zhu, Cheng Yang

RNA sequencing analysis of small cell lung cancer reveals candidate chemotherapy insensitivity long noncoding RNAs and microRNAs

Peng Kuang, Peixin Chen, Lei Wang, Wei Li, Bin Chen, Yu Liu, Yi Xu, Hao Wang, Sha Zhao, Lingyun Ye, Feng Yu, Hongbin Ji, Yayi He

Re-excision or “wait and watch” —a prediction model in breast phyllodes tumors after surgery

Xue Chao, Xiaoyan Jin, Cui Tan, Peng Sun, Junwei Cui, Hui Hu, Qian Ouyang, Kai Chen, Wei Wu, Zhanghai He, Yan Nie, Herui Yao

Platelet-rich plasma-enhanced osseointegration of decellularized bone matrix in critical-size radial defects in rabbits

Yi Leng, Guangkai Ren, Yutao Cui, Chuangang Peng, Jincheng Wang, Dankai Wu, He Liu

Teasaponin suppresses Candida albicans filamentation by reducing the level of intracellular cAMP

Ying Li, Mingzhu Shan, Shihui Li, Yuechen Wang, Huan Yang, Ying Chen, Bing Gu, Zuobin Zhu

Development and validation of a predictive nomogram for the risk of recurrence in patients with cystitis glandularis

Jiao Hu, Chao Li, Xi Guo, Huihui Zhang, Huihuang Li, Dongxu Qiu, Guanghui Gong, Peihua Liu, Wenbiao Ren, Jinbo Chen, Xiongbing Zu

Laparoscopic liver resection with simultaneous diaphragm resection

Airazat M. Kazaryan, Davit L. Aghayan, Åsmund A. Fretland, Vasiliy I. Semikov, Alexander M. Shulutko, Bjørn Edwin

Early oral nutrition improves postoperative ileus through the TRPA1/CCK1-R-mediated mast cell-nerve axis

Da-Li Sun, Yu-Xing Qi, Ting Yang, Yue-Ying Lin, Shu-Min Li, Yi-Jun Li, Qing-Wen Xu, Yan-Bo Sun, Wei-Ming Li, Xiong-Zhi Chen, Peng-Yuan Xu

The role of the CDCA gene family in ovarian cancer

Chongxiang Chen, Siliang Chen, Ma Luo, Honghong Yan, Lanlan Pang, Chaoyang Zhu, Weiyan Tan, Qingyu Zhao, Jielan Lai, Huan Li

Tumor slice culture as a biologic surrogate of human cancer

Heidi L. Kenerson, Kevin M. Sullivan, Yongwoo D. Seo, Kathryn M. Stadeli, Cigdem Ussakli, Xiaowei Yan, Chris Lausted, Venu G. Pillarisetty, James O. Park, Kimberly J. Riehle, Matthew Yeh, Qiang Tian, Raymond S. Yeung

Review Article

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Bariatric surgery and gastroesophageal reflux disease

Darius Ashrafi, Emma Osland, Muhammed Ashraf Memon

Laparoscopic adjustable gastric banding, the past, the present and the future

Niccolò Furbetta, Rosa Cervelli, Francesco Furbetta

Impact of bariatric surgery on cancer risk reduction

Debora S. Bruno, Nathan A. Berger

Endoscopic intragastric balloon: a gimmick or a viable option for obesity?

Katja Susanne Claudia Gollisch, Dirk Raddatz

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

The diagnostic utility of pleural markers for tuberculosis pleural effusion

Man Zhang, Dan Li, Zhi-De Hu, Yuan-Lan Huang

Timing it right: the challenge of recipient selection for lung transplantation

Henry W. Ainge-Allen, Allan R. Glanville

Infection prophylaxis and management of viral infection

Emily S. Clausen, Lorenzo Zaffir

Using artificial intelligence to improve medical services in China

Ruiyang Li, Yahan Yang, Shaolong Wu, Kai Huang, Weirong Chen, Yizhi Liu, Haotian Lin

The combination of brain-computer interfaces and artificial intelligence: applications and challenges

Xiayin Zhang, Ziyue Ma, Huaijin Zheng, Tongkeng Li, Kexin Chen, Xun Wang, Chenting Liu, Linxi Xu, Xiaohang Wu, Duoru Lin, Haotian Lin

Advances in laboratory assays for detecting human metapneumovirus

Seri Jeong, Min-Jeong Park, Wonkeun Song, Hyon-Suk Kim

From the perspective of embryonic tendon development: various cells applied to tendon tissue engineering

Fangjie Qi, Zhantao Deng, Yuanchen Ma, Shuai Wang, Chang Liu, Fengjuan Lyu, Tao Wang, Qiujian Zheng

Diabetes and carotid artery disease: a narrative review

Niki Katsiki, Dimitri P. Mikhailidis

An update on chronic lung allograft dysfunction

Sakhee Kotecha, Miranda A. Paraskeva, Kovi Levin, Gregory I. Snell

Diabetes improvement and bariatric surgery—review of laparoscopic Roux-en-Y gastric bypass vs. laparoscopic vertical sleeve gastrectomy

Jeffrey Gu, Ashley Vergis

Antibody-mediated rejection after lung transplantation

Amit I. Bery, Ramsey R. Hachem

Killer immunoglobulin-like receptors/human leukocyte antigen class-I, a crucial immune pathway in cancer

Yi Xu, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Yayi He, Caicun Zhou

Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system

Wei Liu, Jialong Yan, Weinan Pan, Mengjie Tang

Laparoscopic vertical sleeve gastrectomy, long and short-term impact on weight loss and associated co-morbidities

Leena Khaitan, Brian J. Shea

Radiographic assessment of the cup orientation after total hip arthroplasty: a literature review

Jing-Xin Zhao, Xiu-Yun Su, Zhe Zhao, Ruo-Xiu Xiao, Li-Cheng Zhang, Pei-Fu Tang

Elucidating the molecular signaling pathways of WAVE3

Urna Kansakar, Wei Wang, Vesna Markovic, Khalid Sossey-Alaoui

Cardiovascular risk reduction following metabolic and bariatric surgery

Wayne J. English, Matthew D. Spann, Chetan V. Aher, D. Brandon Williams

Surgical Technique

Hysteroscopic removal of angular retained products of conception hidden behind intrauterine adhesions using a 12-Fr spoon-shaped forceps

Aiqian Zhang, Huan Huang, Xian Qin, Arvind Burjoo, Nidhi, Dabao Xu, Chunxia Cheng

Hysteroscopic adhesiolysis using blunt spreading dissection technique in severe intrauterine adhesions with false passage

Xiuting Zhu, Xingping Zhao, Xiangyang Zeng, Arvind Burjoo, Yimin Yang, Dabao Xu

Study Protocol

A predictive analysis approach for paediatric and adult high-grade glioma: miRNAs and network insight

Anqi Liu, Hengyu Zhao, Banghao Sun, Xue Han, Danyang Zhou, Zhongqi Cui, Xiaoyu Ma, Jianan Zhang, Lijie Yuan

Technical Note

Anterior decompression through transoral axis slide and rotation osteotomy for salvage of failed posterior occipitocervical fusion: a novel technique note

Aimin Wu, Haiming Jin, Haicheng Dou, Xiangxiang Pan, Sunren Sheng, Chongan Huang, Xiangyang Wang

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

2019-nCoV Pneumonia Column more

Protocol for the development of a rapid advice guideline for prevention, management and care of children with 2019 novel coronavirus infection

In December 2019, a new type of Coronavirus that causes pneumonia was first detected in Wuhan,... More >>

Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis

Backgrounds: An ongoing outbreak of pneumonia caused by a novel coronavirus [severe acute... More >>

Measures and suggestions for the prevention and control of the novel coronavirus in dental institutions

Since the first cases of pneumonia of an unknown origin were identified in Wuhan, the capital... More >>

iMDT Corner more

Pulmonary lesions associated with sputum culture-positive actinomycetes: report of one case

Pulmonary lesions associated with sputum culture-positive actinomycetes: report of one case More >>

Left destroyed lung caused by a pen cap in the left lower lobe bronchus “swallowed” 25 years ago

Left destroyed lung caused by a pen cap in the left lower lobe bronchus “swallowed” 25 years ago More >>

Conversion therapy from N3 unresectable lung adenocarcinoma to radical surgery: a case report

Huali Hu, Shuai Zou, Ruofu Xu, Yoshinobu Ichiki, Dirk De Ruysscher, Fenglei Yu, Aihui Liao More >>

Focused Issues (Published) more

In this special issue of Annals of Translational Medicine focused on advances in knee rehabilitation, well-distinguished clinicians, and researchers address recent advances and problems related to orthopedic knee rehabilitation. I selected most relevant problems of the knee dysfunction such as, osteoarthritis of the knee joint, ligament injuries and post operative management of total knee arthroplasty (TKA).

Focused Issue on Recent Advances in Knee Rehabilitation More >>

This focused issue presents a collection of review articles on pediatric acute respiratory distress syndrome (PARDS). Despite a trend toward improved outcomes over the past decade or so, PARDS still leads to significant morbidities and mortality. This collection of review articles provides a comprehensive overview on this important disease in the pediatric critical care environment.

Focused Issue on Pediatric Acute Respiratory Distress Syndrome More >>