Home - Annals of Translational Medicine

Focused Issue on Cancer Metastasis: Molecular Signaling and Therapeutic

This Focused Issue on “Cancer Metastasis: Molecular Signaling and Therapeutic” is edited by Dr. Khalid Sossey-Alaoui, PhD, from Division of Cancer Biology, MetroHealth Medical Research Center, MetroHealth System, Cleveland, Ohio, USA.

Focused Issue on Structural Heart Disease: The Revolution

This focused issue on “Structural Heart Disease: The Revolution” is edited by Dr. Da-niel Hernandez-Vaquero from Cardiac Surgery Department, Heart Area, Hospital Uni-versitario Central de Asturias, Oviedo, Spain.

ATM’s New Journal Impact Factor Released

The editorial office of ATM is pleased to announce that Annals of Translational Medicine received our first Impact Factor: 3.689, indicating that articles published by ATM in 2016 and 2017 were cited an average of 3.689 times in 2018.

Since the launch in 2014, ATM has been strongly supported by the authors, readers, reviewers and editorial board members. We’d like to extend our sincere thanks to all of you who have contributed to our success. We believe this is a good start...

Focused Issue: Recent Developments in Cataract Surgery

This ATM focused issue on Recent Developments in Cataract Surgery is edited by Dr. Andrzej Grzybowski, Professor of Ophthalmology, Chair of Department of Ophthalmology, University of Warmia and Mazury, Olsztyn; Head of Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan, Poland.

Focused Issue on Neurological Diseases

This focused issue on “Neurological Diseases” is edited by Dr. Wei-Hai Xu, Department of Neurology, Peking Union Medical College Hospital, Beijing, China.

Focus on “Wilson’s disease: From Genetics to Management of Disease” edited by Dr. Ralf Weiskirchen and Dr. Wolfgang Stremmel

In this focused issue “Wilson Disease: From Genetics to Management of Disease”, leading experts working in the field of Wilson disease have summarized recent findings and advances in our understanding of this copper overload disease in regard to experimental and clinical aspects. The present knowledge on genetics and pathophysiology in relation to diagnostic and therapeutic procedures is our special interest. Challenges in diagnosis, anti-copper therapies, and clinical practice guidelines will be discussed.

Focused Issue on Current Trends and Advancements in Spine Surgery

This focused isuse on “Current Trends and Advancements in Spine Surgery” is edited by Dr. Kern Singh, from Department of Orthopaedic Surgery, Rush University Medical Center, Co-Director Minimally Invasive Spine Institute, USA

Focused Issue on Strategies to Achieve Long-term Success of Lung Transplantation

This focused issue on “Strategies to Achieve Long-term Success of Lung Transplantation is edited by Dr. Masaaki Sato and Dr. Dong Tian, Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan.

Focused Issue on Stem Cell and Clinical Application

This focusedissue on “Stem Cell and Clinical Application” is edited by Dr. Ling Lu, fromDivision of Liver Surgery, the First Affiliated Hospital of Nanjing MedicalUniversity, Nanjing, China

Focused Issue on The Immature Spine

This focused issue is edited by Dr. Federico Canavese, from Department of Pediatric Orthopedic Surgery, University Hospital Estaing, 1 place Lucie et Raymond Aubrac, Clermont Ferrand 63003, France.

Focused Issue on Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease

This focused issue on “Anticoagulation, Catheterization, and Minimizing Intervention: How Cutting-Edge Cuts Down Disease” is edited by Dr. Rami Khouzam, Professor of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

Focus on “Spinal Tumor Surgery” edited by Dr. Matthew L. Goodwin and Dr. Daniel M. Sciubba

This special issue of Annals of Translational Medicine focuses on tumors in and around the spine. The field of spine tumor surgery is undergoing a transition period, as multidisciplinary care of the patient with the spinal tumor has become the standard of care.

Focus on: “Application of Artificial Intelligence to Radiology” edited by Dr. Timothy Deyer and Dr. Amish Doshi

In this focused issue of the Annals of Translational Medicine “Application of Artificial Intelligence to Radiology”, we explore the use of AI in to specific clinical and operational problems in Radiology.

Focus on “Pompe Disease” edited by Dr. Rosa Puertollano and Dr. Nina Raben

In this special issue of Annals of Translational Medicine, well distinguished clinicians, academic researchers, industry scientists, and patient advocates address recent advances and challenges in current and future therapies for Pompe disease, a prototypical lysosomal storage disorder. As is the case with many maladies, the history of Pompe disease, a severe neuromuscular disorder, is a reflection of the accelerating pace of basic science discoveries and the speed with which scientific knowledge is translated into medical progress.

ATM Annual Report 2018

Greetings from the editorial office of ATM. We wish you a happy new year in the year of 2019. 2018 has seen much progress for the journal:
- ATM is officially indexed in Science Citation Index Expanded (SCIE) at March, 2018
- More than 600 papers have been published on ATM in 2018
- Retrieval of ATM in PubMed increased rapidly to 180, 321 times (monthly) in Nov. 2018
- Number of total citations by SCI journals has significantly increased to 6,922 until Dec. 2018

Join us at the 8TH INTERNATIONAL CONGRESS ON CANCER METASTASIS

This is a very exciting time to be involved in cancer research! The 8th iteration of the Congress brings together international experts in oncology, immunobiology, pharmacology, molecular biology and molecular imaging to discuss preclinical, translational and clinical advances in diagnosing, treating and preventing cancer metastasis as we enter the era of precision medicine. With advancements in cancer care and patient-centered treatment planning, cancer survivors today live longer and enjoy a vastly improved quality of life than thought imaginable. We hope you will participate in 8th International Congress on Cancer Metastasis, scheduled for October 25-27, 2019 in San Francisco, California.For more information: https://cancermetastasis.org/

ATM New Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that, effective June 2019, Dr. Yinghao Sun will be taking over as co-the Editor-in-Chief in tandem with Dr. Xuehao Wang and Dr. Jianxing He.

Dr. Yinghao Sun is a Chief Physician, PhD Supervisor, an Academician of the Chinese Academy of Engineering, the Chief Scientist of 973 programs, and the winner of Ho Leung Ho Lee Foundation Award. He is currently the President of the Second Military Medical University, and he is the Director of the Department of Urology. He is also the Director of the Research Institute for Prostatic Disease of the PLA, and the Director of Changhai da Vinci Robotic Surgery Training Center. Dr. Sun specializes in clinical diagnosis, treatment, and research of urological tumors and urolithiasis, as well as practice and innovate techniques for minimally invasive urological techniques.

ATM New Honorary Editor-in-Chief Announcement

The editorial office of ATM is pleased to announce that Dr. Rafael Rosell, former Editor-in-Chief of the journal, will continuously serve on the editorial board as the Honorary Editor-in-Chief from June 2019.

First of all, we would like to sincerely thank Dr. Rafael Rosell for his hard work and dedication since 2015, without which the journal would not be the success it is today.

Focus on “Lower extremity arthroplasty” edited by Dr. Nipun Sodhi, Dr. Joseph O. Ehiorobo, Dr. Hiba K. Anis, Dr. Assem A. Sultan and Dr. Michael A. Mont.

This special section of Annals of Translational Medicine focuses on lower extremity arthroplasty, especially knee and hip pathologies. In this section, a multitude of pertinent topics for orthopaedic surgeons as well as for the general patient population are reviewed.

Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” edited by Dr. Jin-Shing Chen, Dr. Mong-Wei Lin and Dr. Ke-Cheng Chen

Recently, there have been increasingly more advancements in new image diagnostic and therapeutic modalities for use in the diagnosis and management of thoracic diseases. The use of low-dose computed tomography screening is increasing, thus resulting in an increase in the detection rate of early lung cancers.

Focus on “Clinical Evaluation of Evidence Based on Traditional Chinese Medicine” edited by Dr. Bo Li

Ever since an awareness of two distinct cultural conceptions of healthcare has emerged, the debate concerning whether evidence-based medicine and Traditional Chinese medicine (TCM) are incompatible or whether they can in fact be unified, has continued.

‹ ›

Vol 7, No 17 (September, 2019)

About atm

Manuscript Submission

AME Editing Service

Reprint & Permission

Advertising

Contact us

General editorial enquiries:
Email: editor@atmjournal.org
Copyright related contact:
Email: permissions@amegroups.com
Commercial Sales contact (Reprints, advertising, etc.):
Email: sales@amegroups.com

Meet The Professor more

Dr. Zhouqiao Wu: the magic of change More >>

Experience in article writing about academic research and social issues More >>

Prof. Bin Zhang: no pains, no gains More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Anticoagulation, catheterization, and minimizing intervention: how cutting-edge cuts down disease

Rami N. Khouzam

PDF Full Text

Editorial Commentary

The death of aspirin for primary prevention—should aspirin be changed to a prescription only medication?

Aranyak Rawal, Brandon Cave, Devarshi Ardeshna, David Hana, Uzoma N. Ibebuogu, Rami N. Khouzam

PDF Full Text

Wearable cardioverter defibrillators: dead on arrival or chance of survival?

Pooja S. Jagadish, Rami N. Khouzam

PDF Full Text

Review Article

The dilemma of aspirin resistance in obese patients

Devarshi Ardeshna, Sarthak Khare, Pooja S. Jagadish, Venugopal Bhattad, Brandon Cave, Rami N. Khouzam

PDF Full Text

From WOEST to AUGUSTUS: a review of safety and efficacy of triple versus dual antithrombotic regimens in patients with atrial fibrillation requiring percutaneous coronary intervention for acute coronary syndrome

David W. Jones, Sheharyar Minhas, Joseph J. Fierro, Devarshi Ardeshna, Aranyak Rawal, Brandon Cave, Samarth P. Shah, Rami N. Khouzam

PDF Full Text

Ticagrelor or prasugrel vs. clopidogrel in combination with anticoagulation for treatment of acute coronary syndrome in patients with atrial fibrillation

Irene Kirolos, Ikechukwu Ifedili, Miguel Maturana, Alykhan Moez Premji, Brandon Cave, Sherif Roman, David Jones, Romany Gaid, Yehoshua C. Levine, Sunil Jha, Rajesh Kabra, Rami N. Khouzam

PDF Full Text

Post-operative atrial fibrillation: should we anticoagulate?

Pooja S. Jagadish, Irene Kirolos, Sarthak Khare, Aranyak Rawal, Victor Lin, Rami N. Khouzam

PDF Full Text

Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events

Venugopal B. Bhattad, Sathvika Gaddam, Margaret A. Lassiter, Pooja S. Jagadish, Devarshi Ardeshna, Brandon Cave, Rami N. Khouzam

PDF Full Text

P2Y12 inhibitors: do they increase cancer risk?

Joseph J. Fierro, Brandon Cave, Rami N. Khouzam

PDF Full Text

Targeting ticagrelor: a novel therapy for emergency reversal

Brandon Cave, Aranyak Rawal, Devarshi Ardeshna, Uzoma N. Ibebuogu, Chittoor B. Sai-Sudhakar, Rami N. Khouzam

PDF Full Text

Current status of oral anticoagulant reversal strategies: a review

Aranyak Rawal, Devarshi Ardeshna, Sheharyar Minhas, Brandon Cave, Uzoma Ibeguogu, Rami Khouzam

PDF Full Text

Is early invasive management as ST elevation myocardial infarction warranted in de Winter’s sign?—a “peak” into the widow-maker

Joel M. Raja, Amit Nanda, Issa Pour-Ghaz, Rami N. Khouzam

PDF Full Text

After COACT trial—new perspectives for the management of non-ST elevation myocardial infarction: early versus late cardiac catheterization post cardiac arrest

Miguel A. Maturana, Charles F. Clinton, Selene Caballero-Cummings, Brandon Cave, Amal Khan, Amit Nanda, Devarshi Ardeshna, Joel Raja, Rami N. Khouzam

PDF Full Text

Barriers physicians face when referring patients to cardiac rehabilitation: a narrative review

Carol Elsakr, David A. Bulger, Sherif Roman, Irene Kirolos, Rami N. Khouzam

PDF Full Text

Action plan for improving cardiac rehabilitation-related outcomes in a university hospital based on a review of previous interventions

Carol Elsakr, Leesa Wright, Pooja S. Jagadish, David A. Bulger, Uzoma N. Ibebuogu, Rami N. Khouzam

PDF Full Text

Cardiac physiology in post myocardial infarction patients: the effect of cardiac rehabilitation programs—a systematic review and update meta-analysis

Irene Kirolos, Danny Yakoub, Fiorella Pendola, Omar Picado, Aghapy Kirolos, Yehoshua C. Levine, Sunil Jha, Rajesh Kabra, Brandon Cave, Rami N. Khouzam

PDF Full Text

Apple Watch, Wearables, and Heart Rhythm: where do we stand?

Joel M. Raja, Carol Elsakr, Sherif Roman, Brandon Cave, Issa Pour-Ghaz, Amit Nanda, Miguel Maturana, Rami N. Khouzam

PDF Full Text

CardioMEMS: where we are and where can we go?

Issa Pour-Ghaz, David Hana, Joel Raja, Uzoma N. Ibebuogu, Rami N. Khouzam

PDF Full Text

Is there an optimal “door to cath time” in the treatment of acute pulmonary embolism with catheter-directed thrombolysis?

Aranyak Rawal, Devarshi Ardeshna, Kirstin Hesterberg, Brandon Cave, Uzoma N. Ibebuogu, Rami N. Khouzam

PDF Full Text

Transcatheter aortic valve replacement with a focus on transcarotid: a review of the current literature

Issa Pour-Ghaz, Joel Raja, Mahmoud Bayoumi, Theodore Manolukas, Rami N. Khouzam, Uzoma N. Ibebuogu

PDF Full Text

Accuracy of non-invasive and minimally invasive hemodynamic monitoring: where do we stand?

Issa Pour-Ghaz, Theodore Manolukas, Nathalie Foray, Joel Raja, Aranyak Rawal, Uzoma N. Ibebuogu, Rami N. Khouzam

PDF Full Text

The renal resistive index as a new complementary tool to predict microvascular diabetic complications in children and adolescents: a groundbreaking finding

Abeer Ahmed Abdel Maksoud, Sherine Mohamed Sharara, Amit Nanda, Rami N. Khouzam

PDF Full Text

Pectoriloquy

Cardiac technology

Pooja S. Jagadish

PDF Full Text

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Lymphoepithelioma-like intrahepatic cholangiocarcinoma with Epstein-Barr virus infection: report of a rare case

Yuan Ding, Zhongquan Sun, Wanlu You, Sitong Zhang, Chengdong Chang, Sheng Yan, Weilin Wang

Sarcoidosis presenting pulmonary subsolid nodules that mimic lung adenocarcinoma in a patient with history of uveitis and arrhythmia: a case report

Hye Jin Lee, Hyewon Seo, Seung Ick Cha, Tae In Park, Chang Ho Kim, Jaehee Lee

An invasive thymoma extending into the superior vena cava and right atrium

Tao Yang, Ruting Hui, Qingchen Wu, Jie Tian, Huanwen Chen

Column in Laboratory Medicine

Are we overrating the extra-skeletal benefits of oral vitamin D supplementation?

Giuseppe Lippi, Giovanni Targher

Editorial

The Promise of next generation sequencing micro RNA for the discovery of new targets in contrast induced acute kidney injury

Ayman Haq, Peter A. McCullough

Oral post-hydration after primary PCI for STEMI

Jonas Dominik Häner, Lorenz Räber

Editorial Commentary

BRAF mutant metastatic colorectal cancers: new arrows in our quiver

Chiara Cremolini, Roberto Moretto, Gemma Zucchelli, Alfredo Falcone

Treating BRAFV600E metastatic colorectal patients in 2019: a BEACON of hope?

Christelle de la Fouchardiere

Good news from the Da Qing Diabetes Prevention Outcome Study—healthy lifestyles result in long-term cardiovascular benefits

Matti Uusitupa

Radiation and cardiovascular disease

Nicolas Palaskas, Ashley Patel, Syed Wamique Yusuf

Are the long-term outcomes of percutaneous ablation for clinical stage T1 renal tumors similar to those of partial nephrectomy?

Roy Mano, A. Ari Hakimi

Management of brain metastases from renal cell carcinoma

Suguru Shirotake

A TITAN step forward: apalutamide for metastatic castration-sensitive prostate cancer

Daniel Hyuck-Min Kwon, Terence Friedlander

Non-selective beta blockers in cirrhosis: time to extend the indications?

Dev Katarey, Rajiv Jalan

Toxicity of pelvic nodal radiation for localized prostate cancer

Waqar Haque, E. Brian Butler, Bin S. Teh

IMblaze 370: lessons learned and future strategies in colorectal cancer treatment

Mark McGregor, Timothy J. Price

Do we have a “game changer” in treating patients with brain metastasis from renal cell carcinoma?

Olga Vornicova, Gil Bar-Sela

Letter to the Editor

Prognostic effect of allogeneic hematopoietic stem cell transplantation on first and non-first complete remission in acute myeloid leukemia

Ning Hu, Zhiheng Cheng, Yifan Pang, Hongmian Zhao, Hui Ding, Li Chen, Qianyu Li, Yu Han, Tong Qin, Yifeng Dai, Yijie Zhang, Jinlong Shi, Depei Wu, Lin Fu

Critical appraisal of ENGAGES: cognitive dissonance and anesthesia research

Troy S. Wildes, Michael S. Avidan

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Astym^® therapy improves FOTO^® outcomes for patients with musculoskeletal disorders: an observational study

Leah S. Harris, Suzanne Freeman, Ying-Chih Wang

The effect of extension assist orthosis with pneumatic bladders on pain and function for patients with early knee osteoarthritis

Kathleen Madara, Moiyad Aljehani, Federico Pozzi, Elizabeth Colonna, Joseph A. Zeni Jr

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Non-operative treatment options for knee osteoarthritis

Michael DeRogatis, Hiba K. Anis, Nipun Sodhi, Joseph O. Ehiorobo, Morad Chughtai, Anil Bhave, Michael A. Mont

Prevalence of cervical spine degenerative changes in elderly population and its weak association with aging, neck pain, and osteoporosis

Xiao-Rong Wang, Timothy C. Y. Kwok, James F. Griffith, Blanche Wai Man Yu, Jason C. S. Leung, Yì Xiáng J. Wáng

Predictive role of intraoperative clinicopathological features of the central compartment in estimating lymph nodes metastasis status

Rong-Hao Sun, Chao Li, Yu-Qiu Zhou, Yong-Cong Cai, Chun-Yan Shui, Wei Liu, Xu Wang, Din-Fen Zeng, Jian Jiang, Jing-Qiang Zhu

The preventive effect of Chinese herbal preparation Xuebijing against hyperactive inflammation after hepato-pancreato-biliary surgery

Qifan Zhang, Jia Li, Xiaolu Liang, Haorong Xie, Hang Sun, Xinxin Lin, Jie Zhou, Xiangjun He, Bili Zhu

Lower limb arterial intervention or autologous platelet-rich gel treatment of diabetic lower extremity arterial disease patients with foot ulcers

Danlan Pu, Xiaotian Lei, Weiling Leng, Yanling Zheng, Liu Chen, Ziwen Liang, Bing Chen, Qinan Wu

Total bilirubin is negatively related to diabetes mellitus in Chinese elderly: a community study

Ping Zhong, Dongmei Sun, Danhong Wu, Xueyuan Liu

Inpatient burden of esophageal varices in the United States: analysis of trends in demographics, cost of care, and outcomes

Shantanu Solanki, Khwaja Fahad Haq, Raja Chandra Chakinala, Zubair Khan, Wilbert S. Aronow, Muhammad Ali Khan, Mohamed Tausif Siddiqui, Khwaja Saad Haq, Shalom Frager, Maryam Alimirah, Christopher Nabors, David J. Samson, Edward Lebovics, David Cary Wolf

Association between retinol-binding protein 4 concentrations and gestational diabetes mellitus (A1GDM and A2GDM) in different pregnancy and postpartum periods

Xiyu Du, Yunan Dong, Li Xiao, Guang-Hui Liu, Wei Qin, Hong Yu

Increased risk of intracranial hemorrhage in preterm infants with OPRM1 gene A118G polymorphism

Xin-Ru Cheng, Pei-Ge Xia, Zan-Yang Shi, Qian-Ya Xu, Cheng-Han Luo, Meng-Yuan Lei, Qian Zhang

Efficacy and safety of mecapegfilgrastim for prophylaxis of chemotherapy-induced neutropenia in patients with breast cancer: a randomized, multicenter, active-controlled phase III trial

Fengrui Xu, Yang Zhang, Zhanhui Miao, Xiaohua Zeng, Biao Wu, Li Cai, Jinping Liu, Shusen Wang, Xichun Hu, Wenbo Zheng, Zhiyue Chen, Qing Yang, Zefei Jiang

Extensor muscle-preserving laminectomy in treating multilevel cervical spondylotic myelopathy compared with laminoplasty

Zhiming Yu, Da He, Jiachao Xiong, Zhimin Pan, Lingxuan Feng, Jiang Xu, Zhimin Han, Cristian Gragnaniello, Hisashi Koga, Kevin Phan, Parisa Azimi, Jong-Joo Lee, Yoon Ha, Kai Cao

Platelet-derived microparticles promote phagocytosis of oxidized low-density lipoprotein by macrophages, potentially enhancing foam cell formation

Can Feng, Qi Chen, Min Fan, Jun Guo, Yu Liu, Tao Ji, Jiaqi Zhu, Xianxian Zhao

Risk factors for refractory septic shock treated with VA ECMO

Lei Han, Yan Zhang, Yonghui Zhang, Wei Wu, Ping He

The pathways and mechanisms of muramyl dipeptide transcellular transport mediated by PepT1 in enterogenous infection

Guo-Guang Ma1, Bin Shi, Xue-Peng Zhang, Yue Qiu, Guo-Wei Tu, Zhe Luo

Hes1 is associated with long non-coding RNAs in colorectal cancer

Yuqin Zhang, Lin Zheng, Xuejun Lao, Mingbo Wen, Zhipeng Qian, Xin Liu, Hui Tang, Fei Gao

The effect of red blood cell transfusion on plasma hepcidin and growth differentiation factor 15 in gastric cancer patients: a prospective study

Jingfu Liu, Shan Chen, Xianren Ye

TSPAN8 serves as a prognostic marker involving Akt/MAPK pathway in nasopharyngeal carcinoma

Xiao Lin, Zhuofei Bi, Qian Hu, Qingjian Li, Jieqiong Liu, Man-Li Luo, Yanqun Xiang, Herui Yao

The prognostic significance of co-existence ductal carcinoma in situ in invasive ductal breast cancer: a large population-based study and a matched case-control analysis

Hongliang Chen, Fang Bai, Maoli Wang, Mingdi Zhang, Peng Zhang, Kejin Wu

Predicting significance of COX-2 expression of peripheral blood monocyte in patients with coronary artery disease

Qinghua Huang, Xianming Fei, Shengbing Li, Chan Xu, Chunping Tu, Lei Jiang, Mingyi Wo

MYC gene associated polymorphisms and Wilms tumor risk in Chinese children: a four-center case-control study

Jiabin Liu, Rui-Xi Hua, Wen Fu, Jinhong Zhu, Wei Jia, Jiao Zhang, Haixia Zhou, Jiwen Cheng, Huimin Xia, Guochang Liu, Jing He

Livin is involved in TGF-β1-induced renal tubular epithelial-mesenchymal transition through lncRNA-ATB

Jieqing Zhou, Hong Jiang

Moxifloxacin suppresses airway inflammation and modulates expression of caveolin-1 and flotillin-1 in airway smooth muscle cells of asthmatic rats

Hui-Ting Li, Cong Ye, Min Zhou, Yan Yang, Quan Jin, Chun-Feng Pan

Using deep convolutional neural networks for multi-classification of thyroid tumor by histopathology: a large-scale pilot study

Yunjun Wang, Qing Guan, Iweng Lao, Li Wang, Yi Wu, Duanshu Li, Qinghai Ji, Yu Wang, Yongxue Zhu, Hongtao Lu, Jun Xiang

Transcriptional dissection of differentially expressed long non-coding RNAs and messenger RNAs reveals the potential molecular mechanism after kidney transplantation

Hengcheng Zhang, Guodong Shi, Qingqiao Hu, Henglu Zhang, Ming Zheng, Kuirong Jiang, Min Gu

A combination of platelet-to-lymphocyte ratio and carbohydrate antigen 19-9 predict early recurrence after resection of pancreatic ductal adenocarcinoma

Shinichi Ikuta, Takashi Sonoda, Tsukasa Aihara, Naoki Yamanaka

Ergonomic thoracic port design for video-assisted thoracoscopic minimally invasive esophagectomy and lymphadenectomy: a preliminary pilot study

Han-Yu Deng, Xi Zheng, Guha Alai, Ze-Guo Zhuo, Gang Li, Jun Luo, Yi-Dan Lin

The alterations of gut microbiota in mice with chronic pancreatitis

Man-Man Han, Xiang-Yun Zhu, You-Fan Peng, Hao Lin, De-Chen Liu, Ling Li

Associations of serum sex hormone binding globulin with bone mineral densities and higher 10-year probability of fractures in postmenopausal women with type 2 diabetes mellitus

Yixuan Jing, Xiaofeng Wang, Jingjia Yu, Xiaojing Wang, Yanman Zhou, Bei Tao, Lihao Sun, Jianmin Liu, Hongyan Zhao

MiR-125b-5p targeting TRAF6 relieves skeletal muscle atrophy induced by fasting or denervation

Jiaying Qiu, Jianwei Zhu, Ru Zhang, Wenpeng Liang, Wenjing Ma, Qiuyu Zhang, Ziwei Huang, Fei Ding, Hualin Sun

Plasma miR-146a predicts serological conversion of hepatitis B e-antigen (HBeAg) in chronic hepatitis B patients treated with nucleotide analogs

Yi Ouyang, Xiaoyu Fu, Shifang Peng, Deming Tan, Lei Fu

The proportion of CD19⁺CD24^hiCD27⁺ regulatory B cells predicts the occurrence of acute allograft rejection in liver transplantation

Haoming Zhou, Feng Zhan, Hui Zhang, Jian Gu, Xiaoxin Mu, Ji Gao, Jianhua Rao, Guwei Ji, Xuhao Ni, Ling Lu, Yongxiang Xia

Precision oncology for gallbladder cancer: insights from genetic alterations and clinical practice

Jianzhen Lin, Kun Dong, Yi Bai, Songhui Zhao, Yonghong Dong, Junping Shi, Weiwei Shi, Junyu Long, Xu Yang, Dongxu Wang, Xiaobo Yang, Lin Zhao, Ke Hu, Jie Pan, Xinting Sang, Kai Wang, Haitao Zhao

Femoral and tibial torsion measurements based on EOS imaging compared to 3D CT reconstruction measurements

Wenqiang Yan, Xingquan Xu, Qian Xu, Wenjin Yan, Ziying Sun, Qing Jiang, Dongquan Shi

A lariat-based dilatation device for hysteroscopy: an in vitro study

Donghua Shen, Kaiwei Ma, Mengqian Tian, Lan Li, Qing Jiang, Xingsong Wang

Clinical relevance of mutant-allele tumor heterogeneity and lung adenocarcinoma

Hengyu Mao

Prognostic value of the pretreatment systemic immune-inflammation index (SII) in patients with non-small cell lung cancer: a meta-analysis

Yan Wang, Yina Li, Pingrun Chen, Wenying Xu, Yanming Wu, Guowei Che

Identification of CD2, CCL5 and CCR5 as potential therapeutic target genes for renal interstitial fibrosis

Chuanjie Zhang, Xin Hu, Feng Qi, Jun Luo, Xiao Li

Application of endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal lymphangioma

Runbo Zhong, Xiaoxuan Zheng, Jiajun Teng, Baohui Han

Increased cancer-specific mortality of very small size in carcinoembryonic antigen-elevated rectal cancer

Haiqiang Pan, Junhui Cui, Ke Cai, Yena Zhou

microRNA-1 inhibits cardiomyocyte proliferation in mouse neonatal hearts by repressing CCND1 expression

Jingyi Gan, Florence Mei Kuen Tang, Xianwei Su, Gang Lu, Jing Xu, Henry Siu Sum Lee, Kenneth Ka Ho Lee

Impact of the 21-gene recurrence score assay on chemotherapy decision making and outcomes for breast cancer patients with four or more positive lymph nodes

Qing-Hong Zhang, Wen-Wen Zhang, Jun Wang, Chen-Lu Lian, Jia-Yuan Sun, Zhen-Yu He, San-Gang Wu

Identification of etiologic agents and clinical characteristics for patients suspected of having pertussis in a large Children’s Hospital in China

Yue Tao, Mingyu Tang, Lijuan Luo, Long Xiang, Yijun Xia, Biru Li, Qing Cao, Xi Mo

Multi-targeted tyrosine kinase inhibitors as third-line regimen in advanced non-small cell lung cancer: a network meta-analysis

Zhonghan Zhang, Yuanyuan Zhao, Feiteng Lu, Xue Hou, Yuxiang Ma, Fan Luo, Kangmei Zeng, Shen Zhao, Yaxiong Zhang, Ting Zhou, Yunpeng Yang, Wenfeng Fan, Yan Huang, Li Zhang, Hongyun Zhao

Evaluation of the BioFire FilmArray meningitis/encephalitis panel for the detection of bacteria and yeast in Chinese children

Bailu Du, Chunzhen Hua, Yijun Xia, Jin Li, Yongping Xie, Yue Tao, Qing Cao, Xi Mo

Systemic immune-inflammation index predicts prognosis of bladder cancer patients after radical cystectomy

Wentao Zhang, Ruiliang Wang, Wenchao Ma, Yuan Wu, Niraj Maskey, Yadong Guo, Ji Liu, Shiyu Mao, Junfeng Zhang, Xudong Yao, Yongzhen Liu

Prevalence of hypertension, diabetes, and dyslipidemia, and their additive effects on myocardial infarction and stroke: a crosssectional study in Nanjing, China

Shan Lu, Ming-Yang Bao, Shu-Mei Miao, Xin Zhang, Qing-Qing Jia, Shen-Qi Jing, Tao Shan, Xiao-Hong Wu, Yun Liu

Risk of second primary malignancy after non-small cell lung cancer: a competing risk nomogram based on the SEER database

Huaqiang Zhou, Jiayi Shen, Yaxiong Zhang, Yan Huang, Wenfeng Fang, Yunpeng Yang, Shaodong Hong, Jiaqing Liu, Wei Xian, Zhonghan Zhang, Yuxiang Ma, Ting Zhou, Hongyun Zhao, Li Zhang

Fixation of os acromiale using polyester sutures: a novel surgical treatment

Dun-Ming Guo, Zu-Xi Li, Qing Wang, Huang-He Song

Norepinephrine intravenous prophylactic bolus versus rescue bolus to prevent and treat maternal hypotension after combined spinal and epidural anesthesia during cesarean delivery: a sequential dose-finding study

Tao Xu, Jing Zheng, Xiao-Hu An, Zi-Feng Xu, Fang Wang

Urinary levels of podocyte-derived microparticles are associated with the progression of chronic kidney disease

Jian Lu, Ze-Bo Hu, Pei-Pei Chen, Chen-Chen Lu, Jia-Xiu Zhang, Xue-Qi Li, Ben-Yin Yuan, Si-Jia Huang, Kun-Ling Ma

PQQ ameliorates skeletal muscle atrophy, mitophagy and fiber type transition induced by denervation via inhibition of the inflammatory signaling pathways

Wenjing Ma, Ru Zhang, Ziwei Huang, Qiuyu Zhang, Xiaoying Xie, Xiaoming Yang, Qi Zhang, Hua Liu, Fei Ding, Jianwei Zhu, Hualin Sun

Disparities in outcomes associated with rural-urban insurance status in China among inpatient women with stroke: a registry-based cohort study

Hong-Qiu Gu, Xin Yang, Zhen-Zhen Rao, Chun-Juan Wang, Xing-Quan Zhao, Yi-Long Wang, Li-Ping Liu, Chelsea Liu, Hao Li, Zi-Xiao Li, Yong-Jun Wan, on behalf of China National Stroke Registries investigators

Performance of modified carbapenem inactivation method and inhibitor-based combined disk test in the detection and distinguishing of carbapenemase producing Enterobacteriaceae

Juan Li, Congrong Li, Xuan Cai, Jinling Shi, Lina Feng, Kewen Tang, Yongqing Tong, Yan Li

Review Article

Innovations in functional and rehabilitative knee bracing

Jim Hewlett, John Kenney

Evidence based treatment options for common knee injuries in runners

Simeon Mellinger, Grace Anne Neurohr

Immunotherapy and targeted therapy—the new roadmap in cancer treatment

Kamran Shahid, Mustafa Khalife, Raetasha Dabney, Alexandria Phan

Micronutrient management following bariatric surgery: the role of the dietitian in the postoperative period

Emma Osland, Hilary Powlesland, Taylor Guthrie, Carrie-Anne Lewis, Muhammed Ashraf Memon

Static progressive stretch orthosis—consensus modality to treat knee stiffness—rationale and literature review

Anil Bhave, Nipun Sodhi, Hiba K. Anis, Joseph O. Ehiorobo, Michael A. Mont

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Concise update on colorectal cancer epidemiology

Camilla Mattiuzzi, Fabian Sanchis-Gomar, Giuseppe Lippi

Steroids in pediatric acute respiratory distress syndrome

Nicolás Monteverde-Fernández, Federico Cristiani, Jenniffer McArthur, Sebastián González-Dambrauskas

Red flag rules for knee and lower leg differential diagnosis

Young Jae Kim

Mitochondrion: I am more than a fuel server

Santanu Dasgupta

Rehabilitation protocols following total knee arthroplasty: a review of study designs and outcome measures

Iciar M. Dávila Castrodad, Thea M. Recai, Megha M. Abraham, Jennifer I. Etcheson, Nequesha S. Mohamed, Armin Edalatpour, Ronald E. Delanois

The role of point-of-care ultrasound in pediatric acute respiratory distress syndrome: emerging evidence for its use

Samantha K. Potter, Michael J. Griksaitis

Current criteria for return to play after anterior cruciate ligament reconstruction: an evidence-based literature review

Kala Y. Flagg, Spiridon G. Karavatas, Sam Thompson Jr, Craig Bennett

What do we know about optimal nutritional strategies in children with pediatric acute respiratory distress syndrome?

Rajalakshmi Iyer, Arun Bansal

Transfusion in children with acute respiratory distress syndrome

Tine François, Guillaume Emeriaud, Oliver Karam, Marisa Tucci

Long non-coding RNAs in diseases related to inflammation and immunity

Jiao Chen, Liangfei Ao, Jing Yang

Research progress on KIF3B and related diseases

Lihui Zhou, Lian Ouyang, Keying Chen, Xucan Wang

Approach to Cushing’s syndrome in pregnancy: two cases of Cushing’s syndrome in pregnancy and a review of the literature

Wei Lin, Hui-Bin Huang, Jun-Ping Wen, Neng-Ying Wang, Shuang-Yu Wang, Chen Wang, Gang Chen

Ventilator-induced lung injury in children: a reality?

Alette A. Koopman, Pauline de Jager, Robert G. T. Blokpoel, Martin C. J. Kneyber

Lessons learned in acute respiratory distress syndrome from the animal laboratory

Nadir Yehya

The finer scale of consciousness: quantum theory

Tianwen Li, Hailiang Tang, Jianhong Zhu, John H. Zhang

Gastric cancer surgery: historical background and perspective in Western countries versus Japan

Chun-Dong Zhang, Hiroharu Yamashita, Yasuyuki Seto

Bariatric surgery and gastroesophageal reflux disease

Darius Ashrafi, Emma Osland, Muhammed Ashraf Memon

Pertinent clinical outcomes in pediatric survivors of pediatric acute respiratory distress syndrome (PARDS): a narrative review

Siew Wah Lee, Sin Wee Loh, Chengsi Ong, Jan Hau Lee

Laparoscopic adjustable gastric banding, the past, the present and the future

Niccolò Furbetta, Rosa Cervelli, Francesco Furbetta

Circulating molecular biomarkers for screening or early diagnosis of colorectal cancer: which is ready for prime time?

Elisa Danese, Martina Montagnana, Giuseppe Lippi

The use of allogenic and autologous tissue to treat aortic valve endocarditis

Francesco Nappi, Sanjeet Singh Avtaar Singh, Mario Lusini, Antonio Nenna, Ivancarmine Gambardella, Massimo Chello

Definition and global epidemiology of pediatric acute respiratory distress syndrome

Fernando Beltramo, Robinder G. Khemani

Sublaminar polyester bands for the correction of idiopathic and neuromuscular scoliosis

Federico Canavese, Antoine Samba

Study Protocol

Blood pressure lowering and stroke prevention: a systematic review and network meta-analysis protocol

Xiao-Ling Zhong, Yi Dong, Wei Xu, Li Sun, Hui-Fu Wang, Hong-Qi Li, Yu-Yuan Huang, Lan Tan, Qiang Dong, Jin-Tai Yu

Oral Taodan granules for mild-to-moderate psoriasis vulgaris: protocol for a randomized, double-blind, multicenter clinical trial

Yi Ru, Xiao-Ning Yan, Su-Qing Yang, Li-Ping Gong, Ling-E Li, Jie Chen, Yi-Ding Zhao, Yue-Peng An, Gang Huang, Jin-Fang Zhang, Qing-Feng Yin, Rui-Ping Wang, Xin Li, Bin Li

Journal Highlight more

Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.