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Focus on “New Image Diagnostic and Therapeutic Modalities in Thoracic Surgery” More >>
Focus on “Inborn Errors of Metabolism” More >>
Focus on “Novel Aspects in Ventilator-associated Pneumonia” More >>


Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

STAG2 loss-of-function mutation induces PD-L1 expression in U2OS cells
Zhirui Nie, Wenwen Gao, Yan Zhang, Yuhe Hou, Jingxian Liu, Zhaoqiang Li, Wei Xue, Xidong Ye, Anmin Jin
AMBRA1-mediated autophagy and apoptosis associated with an epithelial-mesenchymal transition in the development of cleft palate induced by all-trans retinoic acid
Xuan Shu, Zejun Dong, Shenyou Shu
Routine intensive monitoring but not routine intensive care unit-based management is necessary in video-assisted thoracoscopic surgery lobectomy for lung cancer
Seung Eun Lee, Woo Hyun Cho, Sang Kwon Lee, Ki Sup Byun, Bong Soo Son, Doosoo Jeon, Yun Seong Kim, Hye Ju Yeo
Quality in practice: implementation of a clinical outcomes registry in regenerative medicine
Frank Zackary Jenio, Corey Scholes, Maimuna Marenah, Jinjie Li, Mac Cowley, Milad Ebrahimi, Meredith Harrison-Brown, William D. Murrell
The effect of walnut rolling training on hand function and corticospinal tract
Sung Ho Jang, Tae Ho Kim, Han Do Lee
Transplantation of dental tissue-derived mesenchymal stem cells ameliorates nephritis in lupus mice
Xiaojun Tang, Wenchao Li, Xin Wen, Zhuoya Zhang, Weiwei Chen, Genhong Yao, Hongwei Chen, Dandan Wang, Songtao Shi, Lingyun Sun
Baseline serum lactate dehydrogenase level predicts survival benefit in patients with metastatic colorectal cancer receiving bevacizumab as first-line chemotherapy: a systematic review and meta-analysis of 7 studies and 1,219 patients
Wanjing Feng, Yue Wang, Xiaodong Zhu
Enhancing autophagy protects platelets in immune thrombocytopenia patients
Chun-Yan Wang, Sai Ma, Shao-Jie Bi, Le Su, Shu-Ya Huang, Jun-Ying Miao, Chun-Hong Ma, Cheng-Jiang Gao, Ming Hou, Jun Peng
Ability of serum procalcitonin to distinguish focus of infection and pathogen types in patients with bloodstream infection
Yinzhi Leng, Caiyun Chen, Yongxiang Zhang, Can Luo, Bo Liu
Investigating the dysfunctional pathogenesis of Wilms’ tumor through a multidimensional integration strategy
Wenbiao Chen, Jia Zhuang, Lan Gong, Yong Dai, Hongyan Diao
Deep learning based classification of ultrasound images for thyroid nodules: a large scale of pilot study
Qing Guan, Yunjun Wang, Jiajun Du, Yu Qin, Hongtao Lu, Jun Xiang, Fen Wang
Polymorphisms in microRNA let-7 binding sites of the HIF1AN and CLDN12 genes can predict pathologic complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer
Yueyao Du, Liheng Zhou, Yanping Lin, Kai Yin, Wenjin Yin, Jinsong Lu
Complete percutaneous laparoscopic cholecystectomy by employing the Percuvance Percutaneous Surgical System
Konstantinos Sapalidis, Athanasios Katsaounis, Stylianos Mantalovas, Christoforos Kosmidis, Ioannis Passos, Dimitrios Giannakidis, Efstathios Pavlidis, Nikolaos Michalopoulos, Charilaos Koulouris, Stelian Mogoanta, Valeriu Surlin, Aikaterini Amaniti, Paul Zarogoulidis, Isaak Kesisoglou
Genomic alterations and survival in young patients aged under 40 years with completely resected non-small cell lung cancer
Shifeng Yang, Zhengbo Song, Guoping Cheng
MicroRNA-200c-3p/ZEB2 loop plays a crucial role in the tumor progression of prostate carcinoma
Jiayi Zhang, Hengcheng Zhang, Yuan Qin, Chen Chen, Jie Yang, Ninghong Song, Min Gu
M2 macrophages promote pulmonary endothelial cells regeneration in sepsis-induced acute lung injury
Yaxing Shen, Jieqiong Song, Yingqin Wang, Zhenglong Chen, Lin Zhang, Jie Yu, Duming Zhu, Ming Zhong
Exploration of high-risk factors for pulmonary embolism in patients undergoing postoperative anti-thrombotic therapy among gynecologic oncology surgery: a retrospective study
Tongyu Liu, Shao-Wei Lin, Su Lin, Lin Yang, Haizhou Ji, Jianping Zou, Rong Xie
Evaluation of the association between the −1304T>G polymorphism in the promoter of the MKK4 gene and the risk of colorectal cancer: a PRISMA-compliant meta-analysis
Rui Bai, Cheng Yuan, Fuxiang Zhou, Lihua Ni, Yan Gong, Conghua Xie
Retrospective study of the interlaminar approach for percutaneous endoscopic lumbar discectomy with the guidance of pre-operative magnetic resonance neurography
Yanhong Liu, Shengtao Wang, Congxian Yang, Bo Zhong, Siyan Zhang, Jian Li, Zhijian Fu
Clinical outcomes following long GnRHa ovarian stimulation with highly purified human menopausal gonadotropin plus rFSH or rFSH in patients undergoing in vitro fertilization-embryo transfer: a multi-center randomized controlled trial
Li Shu, Qianhua Xu, Qingxia Meng, Xue Dai, Yun Zhang, Wei Zhou, Honggang Yi, Jinyong Liu, Chunxiang Wu, Zhen Hou, Yugui Cui, Tin Chiu Li, Jiayin Liu

Review Article

Anti-inflammatory therapy for cardiovascular disease
Constantine E. Kosmas, Delia Silverio, Andreas Sourlas, Peter D. Montan, Eliscer Guzman, Mario J. Garcia
A paradigm shift in biomarker guided oncology drug development
Jan Trøst Jørgensen

Case Report

Pulmonary metastases of fibrosarcomatous dermatofibrosarcoma protuberans respond to apatinib-based angiogenesis and chemotherapy: a case report
Huimin Chen, Yongmei Liu, Feng Peng, Juan Huang, Xiang Wen, Zhenyu Ding, Shouyue Zhang, Yan Zhang, You Lu
Lipoblastoma of the left kidney: a case report and review of literature
Yangsheng Shi, Kang Yang, Man Zhang, Cheng Yi, Junfeng Yu

Visualized Surgery

The application of selective neck dissection while preserving the cutaneous branches of cervical plexus in the surgical treatment of differentiated thyroid cancer—experiences from thousands of cases
Ning Qu, Ting-Ting Zhang, Shi-Shuai Wen, Jun Xiang, Rong-Liang Shi, Guo-Hua Sun, Cai-Ping Huang, Yu Wang, Duan-Shu Li, Qing-Hai Ji, Qiang Shen

Big-data Clinical Trial Column

Predictive analytics with gradient boosting in clinical medicine
Zhongheng Zhang, Yiming Zhao, Aran Canes, Dan Steinberg, Olga Lyashevska, written on behalf of AME Big-Data Clinical Trial Collaborative Group


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Review Article

Original Article

Case Report

Surgical Technique

Editorial Commentary