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Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to clinical practice at the bedside” edited by Prof. Paolo Pelosi and Dr. Lorenzo Ball

In recent years, the role of protective mechanical ventilation has gained increasing importance in the clinical management of not only patients with acute respiratory distress syndrome, but also in those patients requiring respiratory support for non-pulmonary reasons or during general anesthesia.

Focus on “Cardiopulmonary Interactions” edited by Dr. Antoine Vieillard-Baron

This new issue of Annals of Translational Medicine is dedicated to the discussion of issues concerning the heart-lung interactions in critically-ill patients. This is indeed a key subject for several reasons: (I) many patients in the ICU are submitted to positive pressure ventilation; (II) the possible application of heart-lung interactions to bedside old but still very actual physiology makes for exciting study; (III) development of critical care echocardiography allows physicians to easily and accurately evaluate heart-lung interactions in the ICU;

Focus on “Rare and orphan disorders: an emerging challenge?” edited by Prof. Giuseppe Lippi and Dr. Elisa Danese

Rare (often called “orphan”) diseases are conventionally defined as those affecting a very low number of individuals, but which can be associated with inappropriate management, chronic debilitation and adverse health outcome, up to death. This problematic definition is, quite understandably, a major drawback that many scientists, clinicians and laboratory professionals recognize while facing very uncommon pathologies.

Focus on “Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care” edited by Prof. Keith C. Ferdinand

This special issue of the ATM provides perspectives on cardiovascular disease (CVD) not only in the United States (US), but also worldwide. We present a global, comprehensive view of innovative research, reviews, editorials and perspectives from basic science at the bench level to clinic interventions and public health considerations. While this edition of ATM builds on much of the research and clinical care conducted at Tulane University School of Medicine in New Orleans, Louisiana, USA, it also highlights provocative insights from other authors from the USA, along with articles from basic science researchers, clinicians and public health specialists from Africa, Europe, Asia and South America.

Introduction of ATM “Corresponding Authors” Column

Annals of Translational Medicine (ATM) editorial office has launched a column called "Corresponding Authors" to highlight their works published in AMT in order to express our gratitude for their continuous support to our journal.

Focus on “Molecular Medicine” edited by Dr. Christina Piperi and Dr. Athanasios G. Papavassiliou

Welcome to this thematic issue of Annals of Translational Medicine on the recent advances of the ever-expanding field of molecular medicine. The present volume attempts to cover current genetic, molecular, or cellular aspects of main subject areas including microbiology, haematology, biomechanics, oncology, endocrinology, pharmacology, cardiology and hepatology. It is primarily focused on recent developments on molecular biomarkers and current technologies that elucidate disease pathogenesis and may lead to the design of specific tools for diagnosis, treatment, or disease prevention

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Articles from these leading researchers, taken together, effectively paint the picture on a wide canvas and shine a spotlight on critical issues facing the translational oncology community. These leading experts provide a state-of-the-art assessment of timely questions spanning cancer research, from bedside to clinic (and back), including but not limited to accurate molecular assessment of genomic profiles, predictive and prognostic biomarkers, determination of appropriate treatments based on economic profiles, and also the financial toxicity stemming from the recent new wave of effective but expensive cancer-targeting therapies in lung cancer, breast cancer, colorectal cancer, and prostate cancer.

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Lung cancer remains the leading cause of cancer related death worldwide, with approximately 1.6 million deaths recorded in 2015. Non-small cell lung cancer (NSCLC) accounts for approximately 80–85% of cases. Despite broad advances in diagnostics and therapy, the 5-year overall survival for patients with advanced NSCLC has not significantly changed over the past few years. Following the decoding of human cancer genome and the advent of therapies targeting driver mutations, the choice of systemic therapy changed from “one size fits all” approach to a more precise selection of biologic therapies targeting distinct genetic profiles, the so-called “precision” medicine.

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

Good news continues to roll in! Announced by Clarivate Analytics, former Thomson Reuters Intellectual Property and Science Business, Annals of Translational Medicine (known as ATM), under AME Publishing Company, is officially indexed in Science Citation Index Expanded (SCIE) on 02 March, 2018

2017 Annual Report of ATM

We are glad to present the 2017 Annual Report of ATM here. In 2017, ATM progressed fast and smoothly under the join-efforts of experts worldwide. The total citation number has significantly increased from 1294 in January to 3314 in December. The journal was also exhibited in some international meetings, to attract wider attention and exposure. More information is shown in the Annual Report.
We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy, healthy and prosperous 2018!

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

Sleep apnea is associated with worse outcomes following various kinds of surgeries. There is a paucity of data on the association of sleep apnea with clinical outcomes after transcatheter aortic valve replacement (TAVR).

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

Allenbach and colleagues have recently reported for the first time the results of an intriguing study of the histopathologic, immunopathologic and gene expression differences in muscle biopsy tissue from adult dermatomyositis (DM) patients who do and do not have circulating MDA5 autoantibodies (anti-MDA5). Anti-MDA5 were originally identified in a clinically-defined subset of DM patients whose disease was expressed predominately in the skin for unusually long periods of time without accompanying muscle weakness [i.e., “clinically-amyopathic DM” (CADM)] and were at risk for acute, rapidly-progressive form of interstitial lung disease (ILD)...

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Vol 6, No 23 (December, 2018)

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Focused Issues more

Focus on “Respiratory mechanics in mechanically ventilated patients: from physiology to... More >>

Focus on “Cardiopulmonary Interactions” More >>

Focus on “Rare and orphan disorders: an emerging challenge?” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

VEGF inhibitors in EGFR-mutated lung cancer: a never-ending story?

Mariam Alexander, Balazs Halmos

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Radiogenomics as association between non-invasive imaging features and molecular genomics of lung cancer

Stefania Rizzo, Filippo Savoldi, Duccio Rossi, Massimo Bellomi

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Endogenous sex hormones and cardiovascular disease in postmenopausal women: new but conflicting data

Pierre-Yves Scarabin

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Original Article

Preoperative short-term fasting protects liver injury in patients undergoing hepatectomy

Chuanfei Zhan, Xinzheng Dai, Gefengqiang Shen, Xu Lu, Xuehao Wang, Ling Lu, Xiaofeng Qian, Jianhua Rao

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Surgical approach for Siewert type II adenocarcinoma of the esophagogastric junction: transthoracic or transabdominal? —a single-center retrospective study

Zi-Feng Yang, De-Qing Wu, Jun-Jiang Wang, Xing-Yu Feng, Jia-Bin Zheng, Wei-Xian Hu, Yong Li

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Serum uric acid and high-risk pregnancy: an intriguing correlation in advanced pregnant women

You-Fan Peng, Xiang-Hui Su, Man-Man Han, Xiang-Yun Zhu, Ling Li

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Elevation of serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations and its possible atherogenic role in patients with systemic lupus erythematosus

Chenglong Fang, Tingting Luo, Ling Lin

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Red blood cell distribution width (RDW) is an independent predictor of post-implantation syndrome in patients undergoing endovascular aortic repair for abdominal aortic aneurysm

Gian Franco Veraldi, Luca Mezzetto, Lorenzo Scorsone, Marco Macrì, Chiara Bovo, Fabio Simoncini, Paolo Criscenti, Giuseppe Lippi

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Unstable angina: trends and characteristics associated with length of hospitalization in the face of diminishing frequency—an evidence of a paradigm shift

Aaqib H. Malik, Nauman Siddiqui, Wilbert S. Aronow

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Retrospective study on the effects of the prognosis of patients treated with extracorporeal membrane oxygenation combined with continuous renal replacement therapy

Ping He, Shixin Zhang, Bingyang Hu, Wei Wu

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Effects of pre-analytical storage time, temperature, and freeze-thaw times on coagulation factors activities in citrate-anticoagulated plasma

Ying Zhao, Guofang Feng, Limin Feng

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Sphenopalatine ganglion block: an external gate to modulate cardiac autonomic tone and suppress premature ventricular beats?

Dimitrios N. Katsaras, Chrysa K. Arvaniti, Panayota G. Flevari, Georgios V. Giannopoulos, Chrysanthi Z. Batistaki, Vassilios E. Stassinos, Georgia G. Kostopanagiotou, Spyridon G. Deftereos, Efstathios K. Iliodromitis, Dionyssios I. Leftheriotis

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The comparison of teaching efficiency between massive open online courses and traditional courses in medicine education: a systematic review and meta-analysis

Fei Zhao, You Fu, Qi-Jie Zhang, Yue Zhou, Peng-Fei Ge, Hua-Xing Huang, Yuan He

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Methylation of TP53BP2 and Apaf-1 genes in embryonic lung cells and their impact on gene expression

Ying Chen, Jinke Wang, Xin Wang, Yingxun Liu, Bing Gu, Guodong Zhao, Ying Li

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Review Article

Reverse Takotsubo cardiomyopathy: a comprehensive review

Hamza H. Awad, Ashley R. McNeal, Hemant Goyal

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Role of spironolactone in the treatment of heart failure with preserved ejection fraction

Constantine E. Kosmas, Delia Silverio, Andreas Sourlas, Peter D. Montan, Eliscer Guzman

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Case Report

“No drain” uniportal thoracoscopic resection for posterior mediastinal paravertebral Mullerian cyst

Ping-Chung Tsai, Yi-Chen Yeh, Po-Kuei Hsu, Yu-Chung Wu

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Downhill esophageal varices: a therapeutic dilemma

Raja Chandra Chakinala, Anila Kumar, Jonathan E. Barsa, Dhruv Mehta, Khwaja F. Haq, Shantanu Solanki, Virendra Tewari, Wilbert S. Aronow

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A case of osimertinib-resistant lung adenocarcinoma responded effectively to alternating therapy

Haruki Hirakawa, Kazutoshi Komiya, Chiho Nakashima, Shinske Ogusu, Tomomi Nakamura, Masahide Tanaka, Koichiro Takahashi, Yoshiaki Egashira, Keita Kai, Shinya Kimura, Naoko Sueoka-Aragane

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Meet the Professor

Interview questions for Dr. Divya Khosla

Elva S. Zheng

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Colorectal cancer genomics and designing rational trials

Sebastian Mondaca, Rona Yaeger

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Editorial

Hyperphosphatemia: a novel risk factor for mortality in chronic kidney disease

Mario Cozzolino, Paola Ciceri, Andrea Galassi

Clinical benefit of treatment for metastatic renal cell cancer at high volume facilities

Waqar Haque, Monty Aghazadeh, Brian J. Miles, Raj Satkunasivam, E. Brian Butler, Bin S. Teh

BCMA CAR T-cell therapy arrives for multiple myeloma: a reality

Shih-Feng Cho, Kenneth C. Anderson, Yu-Tzu Tai

New perspectives on the role of anti-Müllerian hormone (AMH) in women

Renato Pasquali

Increased circulating choline, L-carnitine and TMAO levels are related to changes in adiposity during weight loss: role of the gut microbiota?

Ellen E. Blaak, Emanuel E. Canfora

CircPVT1: a bridge linking Hippo pathway and human cancers

Xiaoyun He, Weiping Su, Yangying Zhou, Xiaolu Ge, Jianhua Zhou, Chunlin Ou

Current strategies of reduce the rate of dysphagia and dysphonia after anterior cervical spine surgery and role of corticosteroids

Dong Chen, Min Min Shao, Xiang-Yang Wang, Yan Michael Li, Ai-Min Wu

Reflections on the effects of nitric oxide produced by a new dressing in the local management of diabetic foot ulcers

Yolanda García-Álvarez, José Luis Lázaro-Martínez, Raúl Juan Molines-Barroso

Vascular injuries during VATS lobectomies: keep calm, compress and have a plan

Luca Bertolaccini, Francesca Calabrese, Jury Brandolini, Piergiorgio Solli

FOLFOX plus cetuximab in first-line therapy of advanced colorectal cancer

Roland Ehrenberg, Niels Halama

Real-time continuous glucose monitoring decreases the risk of severe hypoglycemia in people with type 1 diabetes and impaired awareness of hypoglycemia

Paola Lucidi, Francesca Porcellati, Geremia B. Bolli, Carmine G. Fanelli

Paradigm shift in the management of type B insulin resistance

Jun Hwa Hong, Hyun Jin Kim, Kang Seo Park, Bon Jeong Ku

What future in the treatment of osteochondral knee defects?

Riccardo D’Ambrosi, Vincenza Ragone, Nicola Ursino

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Bleeding control during VATS major lung resection without conversion: safe and feasible?

Fabrizio Minervini, Peter Bruno Kestenholz, Luca Bertolaccini, Benedetta Bedetti, Davide Patrini, Enrico Cassina, Marco Scarci

Comment on “Sleep disturbances and later cognitive status: a multi-centre study”

Roberto Monastero, Roberta Baschi

Results of the First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults further highlight the need for a novel diabetes classification system

Theocharis Koufakis, Spyridon N. Karras, Pantelis Zebekakis, Kalliopi Kotsa

Editorial on “Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer”

Spencer Hart, Gopal Gupta

Benefit of nephron sparing surgery translates into lower cancer specific mortality in patients with localized renal cell carcinoma

Francesco A. Mistretta, Elio Mazzone, Sophie Knipper, Pierre I. Karakiewicz

Therapeutic strategies for type 2 diabetes mellitus patients with very high HbA1c: is insulin the only option?

Muhammad Abdul-Ghani, Ralph DeFronzo

Non-invasive vascular screening test to diagnose peripheral vascular disease

Lawrence A. Lavery, Peter Andrew Crisologo

Basal insulin reductions in anticipation of multiple exercise sessions in people with type 1 diabetes—a clinical perspective

Olivia McCarthy, Steve C. Bain, Rachel Deere

High-flow oxygen therapy for the management of patients with acute exacerbation of cystic fibrosis

Arnaud W. Thille, Florent Joly, Nicolas Marjanovic, Jean-Pierre Frat

Looking for an effective and non-invasive diagnostic test for endometriosis: where are we?

Pietro G. Signorile, Alfonso Baldi

What the future holds for the primary surgical repair as treatment of a massive pressure ulcer?

Aabid Sanaullah, Mohamed H. Ahmed

Pharmacotherapy in conjunction with lifestyle for the treatment of obesity complications, is it enough?

Werd Al-Najim, Carel W. le Roux

Upfront osimertinib in EGFR-mutated non-small cell lung cancer: is brain still a sanctuary?

Alessandro Leonetti, Francesco Facchinetti, Marcello Tiseo

Refining thoracoscopic left S3 segmentectomy by a unidirectional approach

Wolfgang Jungraithmayr

An editorial on the TAILOR trial—further support for the addition of cetuximab to FOLFOX-4 in the treatment of RAS wild-type metastatic colorectal cancer

Joanna Blanco, Michael Karass

Review Article

The role of integrated behavioral health in caring for patients with metabolic disorders

Neelkamal Soares, Roger W. Apple, Shibani Kanungo

Determination of copper poisoning in Wilson’s disease using laser ablation inductively coupled plasma mass spectrometry

Sabine Weiskirchen, Philipp Kim, Ralf Weiskirchen

Glycogen metabolism and glycogen storage disorders

Shibani Kanungo, Kimberly Wells, Taylor Tribett, Areeg El-Gharbawy

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Fatty acid oxidation disorders

J. Lawrence Merritt II, Marie Norris, Shibani Kanungo

Routine use of commercial antibiotic-loaded bone cement in primary total joint arthroplasty: a critical analysis of the current evidence

Assem A. Sultan, Linsen T. Samuel, Erica Umpierrez, Andrew Swiergosz, Jacob Rabin, Bilal Mahmood, Michael A. Mont

Laboratory diagnostic approaches in metabolic disorders

Ruben Bonilla Guerrero, Denise Salazar, Pranoot Tanpaiboon

Newborn screening and changing face of inborn errors of metabolism in the United States

Shibani Kanungo, Dilip R. Patel, Mekala Neelakantan, Brinda Ryali

Astym^® therapy: A systematic review

Morad Chughtai, Jared M. Newman, Assem A. Sultan, Linsen T. Samuel, Jacob Rabin, Anton Khlopas, Anil Bhave, Michael A. Mont

Lysosomal storage disease overview

Angela Sun

Inborn errors of metabolism in the 21^st century: past to present

Georgianne L. Arnold

Original Article

Long-term effects of acupuncture for chronic prostatitis/chronic pelvic pain syndrome: systematic review and single-arm meta-analyses

Zongshi Qin, Jiani Wu, Chang Xu, Xiaopu Sang, Xiao Li, Guangrui Huang, Zhishun Liu

Deep neural networks could differentiate Bethesda class III versus class IV/V/VI

Yi Zhu, Qiang Sang, Shijun Jia, Ying Wang, Timothy Deyer

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models

John Zech, Jessica Forde, Joseph Titano, Deepak Kaji, Anthony Costa, Eric Karl Oermann

Not all primary total hip arthroplasties are equal—so is there a difference in reimbursement?

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