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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Preoperative short-term fasting protects liver injury in patients undergoing hepatectomy
Chuanfei Zhan, Xinzheng Dai, Gefengqiang Shen, Xu Lu, Xuehao Wang, Ling Lu, Xiaofeng Qian, Jianhua Rao
Surgical approach for Siewert type II adenocarcinoma of the esophagogastric junction: transthoracic or transabdominal? —a single-center retrospective study
Zi-Feng Yang, De-Qing Wu, Jun-Jiang Wang, Xing-Yu Feng, Jia-Bin Zheng, Wei-Xian Hu, Yong Li
Serum uric acid and high-risk pregnancy: an intriguing correlation in advanced pregnant women
You-Fan Peng, Xiang-Hui Su, Man-Man Han, Xiang-Yun Zhu, Ling Li
Elevation of serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations and its possible atherogenic role in patients with systemic lupus erythematosus
Chenglong Fang, Tingting Luo, Ling Lin
Red blood cell distribution width (RDW) is an independent predictor of post-implantation syndrome in patients undergoing endovascular aortic repair for abdominal aortic aneurysm
Gian Franco Veraldi, Luca Mezzetto, Lorenzo Scorsone, Marco Macrì, Chiara Bovo, Fabio Simoncini, Paolo Criscenti, Giuseppe Lippi
Unstable angina: trends and characteristics associated with length of hospitalization in the face of diminishing frequency—an evidence of a paradigm shift
Aaqib H. Malik, Nauman Siddiqui, Wilbert S. Aronow
Retrospective study on the effects of the prognosis of patients treated with extracorporeal membrane oxygenation combined with continuous renal replacement therapy
Ping He, Shixin Zhang, Bingyang Hu, Wei Wu
Effects of pre-analytical storage time, temperature, and freeze-thaw times on coagulation factors activities in citrate-anticoagulated plasma
Ying Zhao, Guofang Feng, Limin Feng
Sphenopalatine ganglion block: an external gate to modulate cardiac autonomic tone and suppress premature ventricular beats?
Dimitrios N. Katsaras, Chrysa K. Arvaniti, Panayota G. Flevari, Georgios V. Giannopoulos, Chrysanthi Z. Batistaki, Vassilios E. Stassinos, Georgia G. Kostopanagiotou, Spyridon G. Deftereos, Efstathios K. Iliodromitis, Dionyssios I. Leftheriotis
The comparison of teaching efficiency between massive open online courses and traditional courses in medicine education: a systematic review and meta-analysis
Fei Zhao, You Fu, Qi-Jie Zhang, Yue Zhou, Peng-Fei Ge, Hua-Xing Huang, Yuan He
Methylation of TP53BP2 and Apaf-1 genes in embryonic lung cells and their impact on gene expression
Ying Chen, Jinke Wang, Xin Wang, Yingxun Liu, Bing Gu, Guodong Zhao, Ying Li

Review Article

Reverse Takotsubo cardiomyopathy: a comprehensive review
Hamza H. Awad, Ashley R. McNeal, Hemant Goyal
Role of spironolactone in the treatment of heart failure with preserved ejection fraction
Constantine E. Kosmas, Delia Silverio, Andreas Sourlas, Peter D. Montan, Eliscer Guzman

Case Report

“No drain” uniportal thoracoscopic resection for posterior mediastinal paravertebral Mullerian cyst
Ping-Chung Tsai, Yi-Chen Yeh, Po-Kuei Hsu, Yu-Chung Wu
Downhill esophageal varices: a therapeutic dilemma
Raja Chandra Chakinala, Anila Kumar, Jonathan E. Barsa, Dhruv Mehta, Khwaja F. Haq, Shantanu Solanki, Virendra Tewari, Wilbert S. Aronow
A case of osimertinib-resistant lung adenocarcinoma responded effectively to alternating therapy
Haruki Hirakawa, Kazutoshi Komiya, Chiho Nakashima, Shinske Ogusu, Tomomi Nakamura, Masahide Tanaka, Koichiro Takahashi, Yoshiaki Egashira, Keita Kai, Shinya Kimura, Naoko Sueoka-Aragane


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.



Review Article

Original Article

Case Report

Expert Consensus

Big-data Clinical Trial Column

Column in Laboratory Medicine