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OCT Angiography in Glaucoma

Therefore the review articles published in current series cover several essential and currently under investigation research areas. The reviews are important for all clinicians dealing with glaucoma patients, researchers working on any of the chronic progressive neurodegenerative diseases one of which is glaucoma, and those engineers, mathematicians and physicists whose research involves clinical aspects.

Gastroesophageal Cancer 2020

This series of Annals of Translational Medicine presents a collection of review articles on the treatment of gastric and gastroesophageal cancer in 2020. The treatment of this cancer has been evolving overtime in both the locally advanced and the metastatic setting. Treatment ranges from Endoscopic resection in early stage disease and perioperative chemotherapy in locally advanced disease to combination of chemotherapy and targeted therapy in the metastatic setting.

Carotid Artery Stenosis and Stroke: Prevention and Treatment Part I

The aim of the current series is to provide an outline of the various controversial issues and techniques, as well as to present the strengths and limitations of the various proposed diagnostic imaging modalities that need to be addressed by future research, thus optimizing stroke outcomes for patients.

Perioperative Management of Patients with Undergoing Mechanical Circulatory Support

In conclusion this special edition focuses the attention of the reader on the next step up for mechanical circulatory support. The excellent survival records move towards reducing complications for even better outcomes. We thank the authors who have vast experience in their field and believe these review articles to be not only discussion of published literature but also be seen through the eyes of the practicing doctor. We hope they will be interesting for many specialities medics and allied professionals who are working with patients in advanced heart failure supported by machines.

Hemodynamic Monitoring in Critically Ill Patients

This series of Annals of Translational Medicine presents a collection of review articles on hemodynamic monitoring in the critically ill patient. The limits and scopes of hemodynamic monitoring has broadened over the last decades with the incorporation of new less invasive techniques such as bedside point-of-care echocardiography. On the other hand, resuscitation concepts have changed and moved from a cardiac output centered approach to perfusion-driven strategies.

Tumor Associated Macrophages in Solid Tumor: Friend or Foe

The focused series aims to highlight the current status of TAMs research in context to solid tumors in a preclinical and clinical setting. We have invited distinguished scientists from the different onco- immunology field for this focused series. I hope, the reviews will help the reader to understand in detail macrophages topographical and temporal heterogeneity and functional diversity in different tumor types.

New Impact Factor for Annals of Translational Medicine: 3.297

We are pleased to announce that the Annals of Translational Medicine (ATM) has attained its latest impact factor update for the 2019 citation year: 3.297.

Here, we would like to extend our heartfelt gratitude to all our Editorial Team Members, Guest Editors, authors, and reviewers for their significant contributions. We look forward to the continuous cooperation with all the individuals mentioned above and those who are interested in translational medicine to bring more exciting content to readers in the coming future. Read More>>

AME entered an official partnership with Publons to enhance wide-ranging recognition for reviewers

AME Publishing Company entered an official partnership with Publons, a product of Clarivate Analytic Company (which owns Web of Science, EndNote, ScholarOne, among many others), as of April 2020. Around 60 AME journals’ peer review systems are now integrated seamlessly into the Publons platform (https://publons.com/about/home). The partnership was done to recognize our expert peer reviewers spontaneously for their review contribution.

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Vol 8, No 22 (November, 2020)

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Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Editorial

Neoadjuvant immunotherapy for patients with non-small cell lung cancer—current evidence

Christopher Cao, Allen Guo, Christopher Chen, Rob Zielinski, Matthew Bott

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Original Article

Analysis of population health projects funded by Joint Fund of the National Natural Science Foundation of China between 2015 and 2019

Rong Lei, Jinglin Zhang, Hongmei Zhou, Quan Liu, Hao Wang, Jia Liu

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Comparative expression analysis of PD-1, PD-L1, and CD8A in lung adenocarcinoma

Ke Ma, Yulei Qiao, Hao Wang, Shuai Wang

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Analysis of the economic performance of municipal Children’s Hospitals in Shanghai: a study on the impacts of policy changes in healthcare service prices

Yuanyuan An, Miao Wang, Xiaoyu Wu, Linan Wang, Kunkun Zhang

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Effects of dexmedetomidine as an adjuvant in thoracic paravertebral block on EC50 of propofol for successful laryngeal mask insertion: a randomized controlled trial

Fei Guo, Hao Chen, Xuejiao Cai, Jianlin Ge, Boxiang Du, Jie Song

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Correlation between alterations of gut microbiota and miR-122-5p expression in patients with type 2 diabetes mellitus

Lisha Li, Chaomin Li, Meijun Lv, Qiongying Hu, Lixuan Guo, Daqian Xiong

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Application of hybrid particle swarm and ant colony optimization algorithms to obtain the optimum homomorphic wavelet image fusion

Yonghong Jiang, Yaning Ma

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Regulatory T cell and activated natural killer cell infiltration in hepatocellular carcinoma: immune cell profiling using the CIBERSORT

Lixin Wang, Zongguo Yang, Yajuan Cao

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Whole-exome sequencing identifies prognostic mutational signatures in gastric cancer

Zhenxin Zhu, Hongbing Fu, Shengzhou Wang, Xinxin Yu, Qing You, Mengyao Shi, Chun Dai, Guan Wang, Wei Cha, Weimin Wang

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A multi-center randomized controlled trial of the LenoMed ATA-I-1-0 insulin pump for the intensive treatment of diabetic patients

Jin Du, Li Zang, Yufeng Li, Jia Liu, Lijuan Wang, Yan Duan, Guangxia Guo, Yijun Li, Yajing Zhang, Guang Wang, Yiming Mu

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The effectiveness of uterine parametrics measured by three-dimensional transvaginal sonography in the diagnosis of uterine cavity distortions

Yan Lin, Min Liu, Suhui He, Minmin Yang, Qiumei Wu

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Remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits IL-1β-induced apoptosis of articular chondrocytes via inhibition of PI3K/AKT/NF-κB phosphorylation

Hai Ke, Xiaping Mou, Qing Xia

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Comparison of internal target volumes defined by three-dimensional, four-dimensional, and cone-beam computed tomography images of a motion phantom

Yu Wang, Tao Liu, Huiqin Chen, Penggang Bai, Qiong Zhan, Xiaohua Liang

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Three-year clinical outcomes of a sirolimus-eluting bioresorbable scaffold (XINSORB) and a metallic stent to treat coronary artery stenosis

Yizhe Wu, Zhifeng Yao, Jiasheng Yin, Jiahui Chen, Juying Qian, Li Shen, Lei Ge, Junbo Ge, on behalf of the XINSORB randomized clinical trial

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A stereological study of 3D printed tissues engineered from rat vaginas

Yanpeng Tian, Shuangdan Zhao, Jiahua Zheng, Zhongkang Li, Chenxiao Hou, Xuejun Qi, Desheng Kong, Jingkun Zhang, Xianghua Huang

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Assessment of neutrophil gelatinase-associated lipocalin as an early biomarker for canine renal ischemia-reperfusion injury

Jun Cao, Xiaofeng Lu, Fei Gao, Xinyu Zhang, Xiaoli Xia, Huaichang Sun

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A HPV16-related prognostic indicator for head and neck squamous cell carcinoma

Qian Zhang, Yongfeng Chen, Shi-Qi Hu, Yu-Mei Pu, Kai Zhang, Yu-Xin Wang

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Target therapy for metastatic alveolar soft part sarcoma: a retrospective study with 47 cases

Jiayong Liu, Zhengfu Fan, Shu Li, Tian Gao, Ruifeng Xue, Chujie Bai, Lu Zhang, Zhichao Tan, Zhiwei Fang

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MUC16 affects the biological functions of ovarian cancer cells and induces an antitumor immune response by activating dendritic cells

Yan Zhai, Qi Lu, Tong Lou, Guangming Cao, Shuzhen Wang, Zhenyu Zhang

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Repair of severe traumatic nasal alar defects with combined pedicled flap and conchal cartilage composite grafts: a retrospective study

Zhenyu Zhang, Lihui Cheng, Tony Chieh-Ting Huang, Hua Hu, Ruiqi Liu, Yi Pu, Ru Wang, Zhengyong Li, Junjie Chen, Ying Cen, Guopeng Liang, Yong Qing

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MicroRNA-29b targeting of cell division cycle 7-related protein kinase (CDC7) regulated vascular smooth muscle cell (VSMC) proliferation and migration

Qunhua Ma, Jing Zhang, Ming Zhang, Huan Lan, Qian Yang, Chengping Li, Li Zeng

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Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation

Chuanmei Xie, Jing Jiang, Jianping Liu, Guohua Yuan, Zhenyi Zhao

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Delivery of vascular endothelial growth factor (VEGFC) via engineered exosomes improves lymphedema

Bohan Li, Jiantao Yang, Raoping Wang, Jia Li, Xubo Li, Xiang Zhou, Shuai Qiu, Ricong Weng, Zichao Wu, Chunyuan Tang, Ping Li

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ET-1 regulates the human umbilical vein endothelial cell cycle by adjusting the ERβ/FOXN1 signaling pathway

Yuyan Wang, Yunjun Ruan, Saizhu Wu

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MicroRNA-25-3p therapy for intervertebral disc degeneration by targeting the IL-1β/ZIP8/MTF1 signaling pathway with a novel thermo-responsive vector

Yong Huang, Leizhen Huang, Li Li, Zhishen Ge, Ganjun Feng, Limin Liu, Yueming Song

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Fucoidan attenuates hyperoxia-induced lung injury in newborn rats by mediating lung fibroblasts differentiate into myofibroblasts

Yan Zhang, Hengjian Du, Xuelian Yu, Jiang Zhu

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Human retinal pigment epithelial cells are protected against hypoxia by BNIP3

Jingyang Feng, Wei Tan, Tong Li, Quan Yan, Hong Zhu, Xiaodong Sun

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Comparison of topological properties of functional brain networks with graph theory in temporal lobe epilepsy with different duration of disease

Xiulin Liang, Xiaomin Pang, Jinping Liu, Jingyuan Zhao, Lu Yu, Jinou Zheng

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Role of lncRNA FTX in invasion, metastasis, and epithelial-mesenchymal transition of endometrial stromal cells caused by endometriosis by regulating the PI3K/Akt signaling pathway

Huixiang Wang, Chengxiang Ni, Wei Xiao, Sulin Wang

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Glycemic variability as predictor of contrast-induced nephropathy in diabetic patients with acute myocardial infarction undergoing percutaneous coronary intervention

Pengfei Zuo, Yongjun Li, Zhi Zuo, Xin Wang, Genshan Ma

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Xiaoyaosan (Tiaogan-Liqi therapy) protects peritoneal macrophages from corticosterone-induced stress by regulating the interaction between glucocorticoid receptor and ABCA1

Mingtai Chen, Ruolan Huang, Wenjun Fu, Lijun Ou, Ling Men, Zhong Zhang, Shudong Yang, Qiang Liu, Jienan Luan

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Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective

Yuying Hao, Pingping Hu, Jiandong Zhang

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LMCD1 antisense RNA 1 (LMCD1-AS1) potentiates thyroid cancer cell growth and stemness via a positive feedback loop of LMCD1-AS1/miR-1287-5p/GLI2

Jie Shao, Yonggang Xu, Haixia Li, Lu Chen, Wenjuan Wang, Danfeng Shen, Jinhong Chen

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Establishment of multiplex allele-specific blocker PCR for enrichment and detection of 4 common EGFR mutations in non-small cell lung cancer

Hongyuan Chen, Jie Zhang, Hong-Yan Chen, Bo Su, Daru Lu

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High concentrations of H7 human embryonic stem cells at the point of care for acute myocardial infarction

Yujie Shi, Ya Zhao, Yang Li, Jun Yi, Yue Ma, Yundai Chen

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Cangxitongbi capsule protects articular cartilage of the knee in rats by regulating ADAMTS-5

Xu-Yu Song, Wen-Peng Xie, Peng Zhang, Min Zhao, Rong-Xiu Bi

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An experimental study on the safe placement of sacroiliac screws using a 3D printing navigation module

Xuanhuang Chen, Feng Zheng, Guodong Zhang, Xiaoqiang Gao, Ya Wang, Wenhua Huang, Haibin Lin

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Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage

Shang Xie, Xiao-Feng Shan, Vicky Yau, Jian-Yun Zhang, Xin-Yuan Zhang, Yong-Pan Yan, Zhi-Gang Cai

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Pressure overload promotes cystatin C secretion of cardiomyocytes to regulate the MAPK signaling pathway and mediate cardiac hypertrophy

Yi Shen, Xiaoyi Zhang, Chenguang Li, Xiang Wang, Yong Ye, Jie Yuan, Hui Gong, Yunzeng Zou, Junbo Ge

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Analysis of the variation pattern in left upper division veins and establishment of simplified vein models for anatomical segmentectomy

Min Zhang, Ning Mao, Ke Zhang, Miao Zhang, Yun Liu, Ren-Feng Wang, Tao Xiong, Gang Huang, Jian-Fei Shen, Jun Liu, Qing-Chen Wu, Ming-Jian Ge

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Genome-wide analysis of long non-coding RNA expression profile in lung adenocarcinoma compared to spinal metastasis

Houlei Wang, Annan Hu, Yun Liang, Ketao Wang, Xiaogang Zhou, Jian Dong

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Efficacy of video-assisted anal fistula treatment combined with closure of the internal opening using a stapler for Parks II anal fistula

Yuru Zhang, Fei Li, Tuanjie Zhao, Feng Cao, Yamin Zheng, Ang Li

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LncRNA FAM83H-AS1 maintains intervertebral disc tissue homeostasis and attenuates inflammation-related pain via promoting nucleus pulposus cell growth through miR-22-3p inhibition

Xin Jiang, Dong Chen

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Glutathione ethyl ester supplementation prevents airway hyper-responsiveness in mice

Qiaoyun Wang, Aimin Li, Yiqiong Zheng, Shu Zhang, Ping Wang

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Reconstruction of the hepatic artery using the superior mesenteric artery for liver transplantation

Jiali Fang, Zheng Chen, Nan Jiang, Qiang He, Shaoping Wang, Weiting Zhang, Junjie Ma, Guanghui Li, Lei Zhang, Lu Xu, Wei Yin, Xingqiang Lai, Rongxin Chen, Li Li, Luhao Liu, Yunyi Xiong, Tao Zhang, Hailin Xu, Jiao Wan, Jialin Wu, Guanghui Pan, Bingyi Shi, Kun Li

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Correlation of carbonic anhydrase 9 (CA9) with pathological T-stage and prognosis in patients with oral tongue squamous cell carcinoma

Shuang Wang, Zhiguang Fu, Yizhu Wang, Yaping Sun, Lei Cui, Chunfang Wang, Qiaoling Liu, Dan Shao, Yu Wang, Ning Wen

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The overexpression of maspin increases the sensitivity of lung adenocarcinoma drug-resistant cells to docetaxel in vitro and in vivo

Qian Sun, Kai Zhang, Huan Li, Weiwei Chen, Leilei Liu, Guichun Huang, Qun Zhang, Jing Wang, Lu Lu, Longbang Chen, Rui Wang

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A study on the pathogenesis of blood-heat psoriasis with transcriptome analysis

Zhaoxia Chen, Yan Wang, Jingxia Zhao, Dongmei Zhou, Jingjing Lv, Guangzhong Zhang, Tingting Di, Ping Li

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Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling

Qiuxian Wan, Lilei Zhang, Ziwei Huang, Haiyan Zhang, Jing Gu, Hua Xu, Xiaoming Yang, Yuntian Shen, Betty Yuen-Kwan Law, Jianwei Zhu, Hualin Sun

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Review Article

Panax notoginseng saponins and their applications in nervous system disorders: a narrative review

Jing Qu, Na Xu, Jianliang Zhang, Xiaokun Geng, Ruihua Zhang

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The role of the programmed cell death protein-1/programmed death-ligand 1 pathway, regulatory T cells and T helper 17 cells in tumor immunity: a narrative review

Lanfang Zhang, Mingjuan Zhang, Jinxiu Xu, Shan Li, Yu Chen, Wenjing Wang, Juntian Yang, Shengyun Li, Meiling Gu

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Study Protocol

Current therapeutic options for coronavirus disease 2019 (COVID-19)—lessons learned from severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) therapy: a systematic review protocol

Zai-Li Zhang, Han Zhong, Yang-Xi Liu, Ke-Jia Le, Min Cui, Yue-Tian Yu, Zhi-Chun Gu, Yuan Gao, Hou-Wen Lin

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iMDT Corner

Transcatheter closure for the treatment of pseudoventricular aneurysm after acute myocardial infarction: a case report

Wei Zhong, Zhidong Liu, Weixiong Fan, Bin Ou, Min Zhong, Zhiwen Zeng, Xianfang Wang, Wilbert S. Aronow, Francesco Nappi, Juan Lacalzada-Almeida, Zhixiong Zhong

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Research trends and performances of breast reconstruction: a bibliometric analysis

Yunzhu Li, Xiaojun Wang, Jørn Bo Thomsen, Maurice Y. Nahabedian, Naohiro Ishii, Warren M. Rozen, Xiao Long, Yuh-Shan Ho

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Editorial Commentary

Tivozanib in advanced inoperable hepatocellular carcinoma: considerations for patients with liver cirrhosis

Hyunwoo Oh, Jeong-Hoon Lee

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Cigarette smoking and lung function decline beyond quitting

Jennifer L. Perret, E. Haydn Walters

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Angiogenesis inhibitors for advanced hepatocellular carcinoma: in search for the right partner

Claudia Campani, Lorenza Rimassa, Nicola Personeni, Fabio Marra

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A biologically effective dose threshold for stereotactic body radiation therapy—can we put the issue to BED?

Michael Mix, Jeffrey A. Bogart

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Macrophage depletion: a potential immunomodulator treatment of endometriosis-associated pain?

Thomas M. D’Hooghe, Arne Vanhie, Valerie A. Flores, Hugh S. Taylor

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Can exenatide flatten the post-prandial glucose curve in type 1 diabetes?

Charlotte K. Boughton, Roman Hovorka

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The LncRNA, the phosphatase, and the macrophage: can they team up for support in inflammatory diseases?

Marcel Kuhny, Michael Huber

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IMPassionate about immunotherapy for TNBC: from change, to revolution and to cure?

Elena Vagia, Massimo Cristofanilli

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MET immunochemistry: a reliable screening tool for MET exon 14 skipping mutations in non-small cell lung cancer?

Melinda A. Pruis, Jan H. von der Thüsen, Hendrikus Jan Dubbink

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Veverimer for treatment of chronic metabolic acidosis in patients with chronic kidney disease

Anirudh R. Gone, Wei Chen

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Editorial on Recent Developments in Cataract Surgery¹

Recent developments in cataract surgery

Andrzej Grzybowski

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Original Article on Recent Developments in Cataract Surgery¹

Cataract complications study: an analysis of adverse effects among 14,520 eyes in relation to surgical experience

Alexander Aaronson, Antti Viljanen, Piotr Kanclerz, Andrzej Grzybowski, Raimo Tuuminen

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Developmental characteristics of the cytokine profile in aqueous humor and its relationship with the inflammatory response in children

Weiyi Lai, Xiaohang Wu, Dongni Wang, Zhenzhen Liu, Duoru Lin, Lanqin Zhao, Weirong Chen, Haotian Lin, Yizhi Liu

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Effect of cataract surgery on quality of life for patients with severe vision impairment due to age-related macular degeneration

Claudia Taipale, Andrzej Grzybowski, Raimo Tuuminen

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Review Article on Recent Developments in Cataract Surgery¹

Lens regeneration in humans: using regenerative potential for tissue repairing

Zhenzhen Liu, Ruixin Wang, Haotian Lin, Yizhi Liu

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Recent developments in the management of congenital cataract

Dominique Bremond-Gignac, Alejandra Daruich, Matthieu P. Robert, Sophie Valleix

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A narrative review of intraoperative floppy iris syndrome: an update 2020

Xue Yang, Zhaochuan Liu, Zhigang Fan, Andrzej Grzybowski, Ningli Wang

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A narrative review of intraocular lens opacifications: update 2020

Andrzej Grzybowski, Agne Markeviciute, Reda Zemaitiene

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Postoperative Endophthalmitis and Toxic Anterior Segment Syndrome Prophylaxis: 2020 Update

Jesse D. Sengillo, Ying Chen, Diley Perez Garcia, Stephen G. Schwartz, Andrzej Grzybowski, Harry W. Flynn Jr

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Intraocular vision-improving devices in age-related macular degeneration

Andrzej Grzybowski, Jin Wang, Feifei Mao, Dabo Wang, Ningli Wang

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The role of lens extraction in glaucoma management

Jolly L. Tsui, Noel C. Chan, Clement C. Tham

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The history of cataract surgery: from couching to phacoemulsification

Christopher T. Leffler, Andrey Klebanov, Wasim A. Samara, Andrzej Grzybowski

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Advances in pharmacotherapy of cataracts

Jingjie Xu, Qiuli Fu, Xiangjun Chen, Ke Yao

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Recent developments in intraocular lens power calculation methods—update 2020

Giacomo Savini, Leonardo Taroni, Kenneth J. Hoffer

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Evolution of and developments in simultaneous bilateral cataract surgery. Update 2020

Gurinder Singh, Andrzej Grzybowski

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Retraction

Retraction “Methylation of the MAOA promoter is associated with schizophrenia”

Hao Yang, Jiajue Li, Aicen Ji, Liping Hu, Xiufeng Zhang, Linlin Liu, Lili Qing, Ming Yan, Shengjie Nie

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Disclosure:

1. The series “Recent Developments in Cataract Surgery” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Andrzej Grzybowski served as the unpaid Guest Editor for the series.

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

Metastatic colorectal cancer in a cirrhotic liver with synchronous hepatocellular carcinoma

Michael Karass, Emily Grossniklaus, Talal Seoud, Ralph Kamel, Oluwadamilola Teniola, Gabriela Oprea, Daniel A. Goldstein, Sanjay Jain

Editorial

Translating L-2-HG to kidney cancer at the bench and bedside

Omran Abu Aboud, Robert H. Weiss

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease

Nicholas S. Burris, Benjamin A. Hoff, Brian D. Ross

Dasatinib in breast cancer: Src-ing for response in all the wrong kinases

Laura C. Kennedy, Vijayakrishna Gadi

Cardiac troponin I—more than a biomarker for myocardial ischemia?

Li Ni, Xander H. T. Wehrens

Ifi204/p204, a new piece in the sepsis puzzle

Gayatri Subramanian, Ritu Chakravarti, Saurabh Chattopadhyay

Fusion heals the broken-hearted

Daniel A. Zuppo, Michael Tsang

Adjuvant antiviral therapy for the prevention of hepatocellular carcinoma recurrence after liver resection: indicated for all patients with chronic hepatitis B?

Clifford Akateh, Timothy M. Pawlik, Jordan M. Cloyd

Acidosis and citrate: provocative interactions

Kathleen S. Hering-Smith, L. Lee Hamm

Protecting functional β cells with a therapeutic peptide

Meghan L. Marré, Jon D. Piganelli, Eddie A. James

The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy

Emil Lou

Protease activated receptor 4: a backup receptor or a dark horse as a target in antiplatelet therapy?

Xu Han, Marvin T. Nieman

Geospatial modelling in guiding health program strategies in resource-limited settings—the way forward

Diane Gu, Chawangwa Modongo, Sanghyuk S. Shin, Nicola M. Zetola

Surrogate end points in early prostate cancer clinical states: ready for implementation?

Christos E. Kyriakopoulos, Emmanuel S. Antonarakis

Profiling of plasma-derived extracellular vesicles cargo for diagnosis of pancreatic malignancy

Theresa L. Whiteside

Evolving treatment options for valve and aortic disease with bicuspid aortic valve

Nicholas S. Burris, Michael D. Hope

Exosomes may play a crucial role in HIV dendritic cell immunotherapy

Benjamin Wolfson, Justine E. Yu, Qun Zhou

Custom cutting guides in total knee arthroplasty

Morad Chughtai, Anton Khlopas, Iyooh U. Davidson, George A. Yakubek, Kim L. Stearns, Michael A. Mont

Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges

Hong Tian, Wei Li

It takes time to tune

Brandon S. Bentzley, Jaspreet Pannu, Bashar W. Badran, Casey H. Halpern, Nolan R. Williams

Intra-luminal focused ultrasound for augmentation of gastrointestinal drug delivery

Ezekiel Maloney, Joo Ha Hwang

Re-assessing stem cells in the stomach—one story two tales

Ming Jiang, Jianwen Que

Extracellular vesicles isolation and their biomarker potential: are we ready for testing?

Theresa L. Whiteside

One size doesn’t fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence

Henry L. Schreiber IV, Caitlin N. Spaulding, Karen W. Dodson, Jonathan Livny, Scott J. Hultgren

Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings

Osamu Baba, Yongjian Liu, Gwendalyn J Randolph

An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus

Adam S Cockrel, Ralph S Baric

Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?

Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir

The evolving approach to sedation in ventilated patients: a real world perspective

Annachiara Marra, Pratik P. Pandharipande

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients

Rami A. Namas, Yoram Vodovotz

Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?

Matthew E. Poynter

Re-assessing the role of non-fasting lipids; a change in perspective

Zareen Farukhi, Samia Mora

Narcolepsy and influenza vaccination—the inappropriate awakening of immunity

Anoma Nellore, Troy D. Randall

A canine model for neuronal ceroid lipofuscinosis highlights the promise of gene therapy for lysosomal storage diseases

Jonathan E. Phillips, Richard H. Gomer

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

The AMPK-SKP2-CARM1 axis links nutrient sensing to transcriptional and epigenetic regulation of autophagy

Ziheng Xu, Daniel J. Klionsky

Is the regulation of SIRT1 by miRNA-34a the key to mesenchymal stem cell survival?

Michael A. Bellio, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The coming of age of adoptive T-cell therapy for viral infection after stem cell transplantation

Austin John Barrett, Catherine M. Bollard

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Editorial Commentary

Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Vibhu Parcha, Pankaj Arora

Pluripotential stem cells as replacement therapy in degenerative diseases of the eye

Colin J. Barnstable

Reactive astrocytes foster brain metastases via STAT3 signaling

Braden C. McFarland, Etty N. Benveniste

Cryo-electron microscopy reveals informative details of GABA_A receptor structural pharmacology: implications for drug discovery

Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou

‘RNA circles of influence’ in Kaposi sarcoma

Dimitrios Tsitsipatis, Myriam Gorospe

A novel macrophage subtype directs hematopoietic stem cell homing and retention

Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida

Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis

Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby

Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

Letter to the Editor

Challenges to interpreting patient reported outcomes in clinical trials: author rejoinder

Melanie L. Bell

Low levels of interleukin-10 in patients with transfusion-related acute lung injury

Rick Kapur, Michael Kim, Johan Rebetz, Matthew T. Rondina, Leendert Porcelijn, John W. Semple

Circulating CD40 autoantibody and suPAR synergy drives glomerular injury

Changli Wei, Tara K. Sigdel, Minnie M. Sarwal, Jochen Reiser

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Original Article

GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis

Hengwei Liu, Wei Zhang, Lili Wang, Zhibing Zhang, Wenqian Xiong, Ling Zhang, Tian Fu, Xiaoou Li, Yaobing Chen, Yi Liu

Genome-wide association study of cerebrospinal fluid neurofilament light levels in non-demented elders

Li-Dong Niu, Wei Xu, Jie-Qiong Li, Chen-Chen Tan, Xi-Peng Cao, Jintai Yu, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress in vitro

Yoram Vodovotz, Richard L. Simmons, Derek Barclay, Jinling Yin, Bahiyyah S. Jefferson, Ruben Zamora

Altering cough reflex sensitivity with aerosolized capsaicin paired with behavioral cough suppression: a proof-of-concept study

Laurie J. Slovarp, Emma Bozarth

Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males

Nazmi Che-Nordin, Min Deng, James F. Griffith, Jason C. S. Leung, Anthony W. L. Kwok, Yue-Qi Zhu, Richard H. Y. So, Timothy C. Y. Kwok, Ping Chung Leung, Yì Xiáng J. Wáng

Genome-wide association study identifies RBFOX1 locus influencing brain glucose metabolism

Ling-Li Kong, Dan Miao, Lin Tan, Shu-Lei Liu, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

ABCA7 genotype altered Aβ levels in cerebrospinal fluid in Alzheimer’s disease without dementia

Fang-Chen Ma, Yu Zong, Hui-Fu Wang, Jie-Qiong Li, Xi-Peng Cao, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Impact factors of orthopaedic journals between 2010 and 2016: trends and comparisons with other surgical specialties

Nequesha S. Mohamed, Chukwuweike U. Gwam, Jennifer I. Etcheson, Nicole E. George, Nicolas S. Piuzzi, Samuel Rosas, Nipun Sohdi, Assem A. Sultan, Anton Khlopas, Ronald E. Delanois

Impact of smoking in patients undergoing transcatheter aortic valve replacement

Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction

Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam

National use of total hip arthroplasty among patients with a history of breast, lung, prostate, colon or bladder cancer—an analysis of the Medicare population

Samuel Rosas, Karim Sabeh, Jennifer Kurowicki, Leonard Buller, Tsun Yee Law, Martin Roche, Sheila Conway, Victor H. Hernandez

Prospective study of quality of life after lung cancer resection

Kathleen G. Hopkins, Peter F. Ferson, Manisha R. Shende, Neil A. Christie, Matthew J. Schuchert, Arjun Pennathur

Probiotics for prevention of urinary stones

John C. Lieske

Variations in mRNA and protein levels of Ikaros family members in pediatric T cell acute lymphoblastic leukemia

Julie L. Mitchell, Thomas M. Yankee

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Review Article

Emerging biomarkers in autism spectrum disorder: a systematic review

Richard E. Frye, Sarah Vassall, Gurjot Kaur, Christina Lewis, Mohammand Karim, Daniel Rossignol

Pompe disease gene therapy: neural manifestations require consideration of CNS directed therapy

Barry J. Byrne, David D. Fuller, Barbara K. Smith, Nathalie Clement, Kirsten Coleman, Brian Cleaver, Lauren Vaught, Darin J. Falk, Angela McCall, Manuela Corti

Liver depot gene therapy for Pompe disease

Priya S. Kishnani, Dwight D. Koeberl

Genetics and epigenetic factors of Wilson disease

Valentina Medici, Janine M. LaSalle

Ventilator-induced lung injury and lung mechanics

Jason H. T. Bates, Bradford J. Smith

Precision oncology in liver cancer

Kevin M. Sullivan, Heidi L. Kenerson, Venu G. Pillarisetty, Kimberly J. Riehle, Raymond S. Yeung

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Aubhishek Zaman, Trever G. Bivona

Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?

Richard D. Sontheimer

Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation

Tara R. Semenkovich, Bryan F. Meyers

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

The female urinary microbiota, urinary health and common urinary disorders

Linda Brubaker, Alan J. Wolfe

The association between bacteria and urinary stones

Andrew L. Schwaderer, Alan J. Wolfe

PDX1 associated therapy in translational medicine

Juehua Yu, Shi-He Liu, Robbi Sanchez, John Nemunaitis, Enrique Rozengurt, F. Charles Brunicardi

Biomarkers of risk to develop lung cancer in the new screening era

Thomas Atwater, Pierre P. Massion

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

Commentary

Vinculin at the heart of aging

William H. Bradford, Jeffrey H. Omens, Farah Sheikh

MET signaling promotes DNA repair and radiation resistance in glioblastoma stem-like cells

Pavlina Krasimirova Todorova, Bipasha Mukherjee, Sandeep Burma

Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity

Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond

Epigenetic therapy in a new era of medicine: creating and integrating molecular profiles of patients

Ebrahim Afshinnekoo, Christopher E. Mason

Patellar resurfacing after endoprosthetic replacement for primary or secondary bone tumors

Alexander D. Liddle

A sensible approach to targeting STAT3-mediated transcription

Neil E. Bhola, Daniel E. Johnson, Jennifer R. Grandis

Circulating fibrocytes serve as a marker for clinical diagnosis

Thuy Cao, Sheeja Rajasingh, Johnson Rajasingh

Collagen and fibronectin: threads linking obesity and breast cancer

Lesley G. Ellies

Abrupt versus gradual smoking cessation with pre-cessation nicotine replacement therapy for cigarette smokers motivated to quit

Elias M. Klemperer, Karl O. Fagerstrom, John R. Hughes

Quantification of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?

Andrew C. McKown, Lorraine B. Ware

TGFβ signaling: a friend or a foe to hepatic fibrosis and tumorigenesis

Dragana Kopanja, Pradip Raychaudhuri

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

Significance of microRNA-based biomarkers for pancreatic cancer

Sukhwinder Kaur, Shiv Ram Krishn, Satyanarayana Rachagani, Surinder K. Batra

Perspective

The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation

Marylyn D. Ritchie, Kristel Van Steen

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

RNAs that make a heart beat

Mithun Mitra, Hilary A. Coller

Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials

Gregory A. Chinn, Jennifer M. Sasaki Russell, Jeffrey W. Sall

Glucose management in the intensive care unit: are we looking for the right sweet spot?

Sarah J. Beesley, Eliotte L. Hirshberg, Michael J. Lanspa

Emerging role of lncRNA in cancer: a potential avenue in molecular medicine

Nidhi Jariwala, Devanand Sarkar

Sarco“MiR” friend or foe: a perspective on the mechanisms of doxorubicin-induced cardiomyopathy

Louis A. Saddic, Jochen D. Muehlschlegel

Improving our understanding of papillary renal cell carcinoma with integrative genomic analysis

Parth K. Modi, Eric A. Singer

Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice

Jac A. Nickoloff

Why we need a new definition of sepsis

Sarah J. Beesley, Michael J. Lanspa

Health Service and Policy Research

Health Services & Policy Research in translational medicine

Nengliang (Aaron) Yao

Editorials

Circulating free DNA in the management of breast cancer

Jacqueline A. Shaw, Justin Stebbing

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Health Service and Policy Research Column

Diabetes management before and after cancer diagnosis: missed opportunity

Nengliang Yao, Fabian T. Camacho, Askar S. Chukmaitov, Steven T. Fleming, Roger T. Anderson

The real difficulty in improving concordance of clinical practice with guidelines

Nengliang Yao, Abram Recht

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Review Article on MET as Actionable Target in Cancer Therapy

MET: roles in epithelial-mesenchymal transition and cancer stemness

Hye-Min Jeon, Jeongwu Lee

Effective implementation of novel MET pharmacodynamic assays in translational studies

Apurva K. Srivastava, Tony Navas, William G. Herrick, Melinda G. Hollingshead, Donald P. Bottaro, James H. Doroshow, Ralph E. Parchment

Perspective on Mesothelioma

Novel immunotherapy clinical trials in malignant pleural mesothelioma

Zachary E. Tano, Navin K. Chintala, Xiaoyu Li, Prasad S. Adusumilli

Review Article on Mesothelioma

Mesothelioma: recent highlights

Michele Carbone, Haining Yang

Environmental asbestos exposure and risk of mesothelioma

Curtis W. Noonan

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Original Article on Translational Neurodegeneration

The impact of GAB2 genetic variations on cerebrospinal fluid markers in Alzheimer’s disease

Xiao-Xiao Chen, Run-Rong Guo, Xi-Peng Cao, Lin Tan, Lan Tan, Alzheimer’s Disease Neuroimaging Initiative

Review Article on Molecular Hepatology

Fibroblast growth factors 19 and 21 in acute liver damage

Zhao Shan, Gloria Alvarez-Sola, Iker Uriarte, María Arechederra, Maite G. Fernández-Barrena, Carmen Berasain, Cynthia Ju, Matías A. Avila

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension

David A. Calhoun

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Review Article on Inborn Errors of Metabolism

Congenital disorders of glycosylation

Irene J. Chang, Miao He, Christina T. Lam

Review Article on Health and Medicine: a new era

Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy

Sachin Kumar Deshmukh, Sanjeev Kumar Srivastava, Teja Poosarla, Donna Lynn Dyess, Nicolette Paolaungthong Holliday, Ajay Pratap Singh, Seema Singh

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Case Report

Atypical hemolytic uremic syndrome after childbirth: a case report

Hong Sang Choi, Jae Won Yun, Hee-Jin Kim, Doyeun Oh, Nah Ihm Kim, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae

Complete response to immunotherapy combined with an antiangiogenic agent in multiple hepatic metastases after radical surgery for advanced gallbladder cancer: a case report

Jianhua Rao, Jinguo Xia, Wenjie Yang, Chen Wu, Bowen Sha, Qitong Zheng, Feng Cheng, Ling Lu

Editorial

Infective endocarditis in the 21th century

Francesco Nappi, Cristiano Spadaccio, Christos Mihos

Endovascular interventions in trauma, an introduction

Keith Bertram Quencer

Ovarian cancer: state of the art and perspectives of clinical research

Stergios Boussios, Nicholas Pavlidis

Editorial Commentary

Tenascin-C: an emerging prognostic biomarker in diabetes

Saori Yonebayashi, Kazuko Tajiri, Siqi Li, Akira Sato

Anti-PD1 monotherapy in hepatocellular carcinoma: a step forward or already behind?

Silvia Catanese, Florian Lordick

Transarterial chemoembolization (TACE) plus sorafenib: a real winning combination?

Xavier Adhoute, Rodolphe Anty, Marc Bourlière

Keynote-158 study, FDA granted accelerated approval of pembrolizumab for the treatment of patients with advanced PD-L1-positive cervical cancer

Edith Borcoman, Christophe Le Tourneau

Optimizing adjuvant therapy in EGFR-mutated non-small cell lung cancer

Annemarie F. Shepherd, Isabel R. Preeshagul, Narek Shaverdian, Abraham J. Wu, Daphna Y. Gelblum, Daniel R. Gomez, Andreas Rimner, Charles B. Simone II

Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma—targeting a novel PD-1 epitope to treat hepatocellular carcinoma

Yannick Sebastiaan Rakké, Dave Sprengers, Jaap Kwekkeboom, Jan Nicolaas Maria IJzermans

The role of c-MET inhibitors in advanced hepatocellular carcinoma: now and future

Hyun Young Woo, Jeong Heo

Devil in the detail: MET overexpression fails as surrogate marker for MET exon 14 splice site mutations in NSCLC

Matthew R. Strickland, Pasi A. Jänne

Paving the way to precision medicine for diabetic kidney disease: the PRIORITY trial

Meir Schechter, Gil Leibowitz, Ofri Mosenzon

Combination of immunotherapy with chemotherapy in first line treatment of metastatic gastric cancer? Too much, too little or just right?

Matthew C. H. Ng, Su Pin Choo

Safety and preliminary signs of efficacy with the combination of pembrolizumab plus oxaliplatin and S-1 in Japanese gastric cancer patients

Maria Alsina, Elizabeth C. Smyth

Endothelial growth factor receptor-mutant lung cancer and post-operative care management: one size does not fit all

Javeryah Safi, Sarah W. Gordon, Peter Lee, Howard Li, Patrick Nana-Sinkam, Rachit D. Shah, Ray W. Shepherd, Samira Shojaee

Home spirometry to assess efficacy of pirfenidone in progressive unclassifiable interstitial lung disease: better the devil you know than the devil you don’t

Giacomo Sgalla, Pier-Valerio Mari, Luca Richeldi

Doxorubicin for the treatment of hepatocellular carcinoma: GAME OVER!

Boris Guiu, Eric Assenat

Exenatide at mealtimes in type 1 diabetes—no MAG1C with exenatide, or with other glucagon-like peptide-1 receptor agonists

Sheila A. Doggrell

Sorafenib plus doxorubicin in advanced hepatocellular carcinoma patients: hope or hype?

Kit Shing, Gerry Kwok, Joanne Chiu, Tan To Cheung, Thomas Yau

Combined locoregional and systemic therapy for advanced hepatocellular carcinoma: finally, the future is obscure

Khashayar Farsad, Nima Nabavizadeh, Adel Kardosh, Janice H. Jou, Willscott E. Naugler, Kenneth J. Kolbeck

Molecular downstaging: a new paradigm for neoadjuvant endocrine therapy

Emanuela Ferraro, Monica N. Fornier

Letter to the Editor

Recommendations for the medical task force against COVID-19: Zhongshan experience in Wuhan

Zhe Luo, Guo-Wei Tu, Qing Yu, Yu-Meng Yao, Yuan Xue, Xiang Chen, Min Fei, Chou-Wen Zhu

Is fibrinogen plasma level a risk factor for the first 24-hour death of medically treated acute type A aortic dissection patients?

Zeyi Cheng, Honghui Wang

Original Article

The correlation between patient reported outcomes and biomarkers for knee osteoarthritis

Bumsup Lee, Martin Wang, Soo-Hyun Lew, Jung Jong Cho, Tae Won Kim, Nipun Sodhi, Hiba K. Anis, Michael A. Mont

Perioperative changes in pelvic tilt after hip resurfacing using a direct lateral approach

Linsen T. Samuel, Jared Warren, Jacob M. Rabin, Alexander J. Acuña, Amy Shuster, Jordan Patterson, Michael A. Mont, Peter J. Brooks

Cementless tapered wedge stems in patients undergoing primary total hip arthroplasty with Dorr C bone—are complication risks increased?

Jonathon Lindner, Jonathan Napier, Anthony Feher, Heather S. Haeberle, Linsen T. Samuel, Michael A. Mont, Ronald Delanois, Arthur L. Malkani

Prediabetes and risk for all-cause and cardiovascular mortality based on hypertension status

Yu-Qing Huang, Lin Liu, Jia-Yi Huang, Chao-Lei Chen, Yu-Ling Yu, Kenneth Lo, Ying-Qing Feng

Myeloid cell leukemia-1 is an important predictor of survival and progression of small cell lung cancer

Ting Zhou, Lin Zhang, Tingting Liu, Yunpeng Yang, Fan Luo, Zhonghan Zhang, Yan Huang, Hongyun Zhao, Li Zhang, Yuanyuan Zhao

CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis

Weidong Shi, Chenyue Zhang, Zhouyu Ning, Yongqiang Hua, Ye Li, Lianyu Chen, Luming Liu, Zhen Chen, Zhiqiang Meng

Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients—a pilot clinical study

Angelos Karlas, Max Masthoff, Michael Kallmayer, Anne Helfen, Michail Bariotakis, Nikolina Alexia Fasoula, Michael Schäfers, Max Seidensticker, Hans-Henning Eckstein, Vasilis Ntziachristos, Moritz Wildgruber

Carbon-ion radiotherapy in the treatment of radiation-induced second primary malignancies

Jing Yang, Jing Gao, Jiyi Hu, Weixu Hu, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

The role of carbon-ion radiotherapy in the treatment of adenoid cystic carcinoma of the nasopharynx

Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu

A comparison of perioperative safety for breast augmentation in cis- vs. trans patients

Kyle S. Gabrick, Fouad Chouiari, Kitae E. Park, Omar Allam, Mohammed Ali Mozaffari, John A. Persing, Michael Alperovich

Intravenous fluids for pain management in head and neck cancer patients undergoing chemoradiation

Charlotte I. Rivers, Austin J. Iovoli, Udit Chatterjee, Gregory M. Hermann, Anurag K. Singh

Protective effect of hydrogen sulfide on endothelial cells through Sirt1-FoxO1-mediated autophagy

Lin Zhu, Wu Duan, Guangjie Wu, Di Zhang, Lan Wang, Dong Chen, Zhishui Chen, Bo Yang

Variable innervation of the first dorsal interosseous muscle: an electrophysiological study

Yang Liu, Jing Rui, Kaiming Gao, Jie Lao

A predictive model for respiratory distress in patients with COVID-19: a retrospective study

Xin Zhang, Wei Wang, Cheng Wan, Gong Cheng, Yuechuchu Yin, Kaidi Cao, Xiaoliang Zhang, Zhongmin Wang, Shumei Miao, Yun Yu, Jie Hu, Ruochen Huang, Yun Ge, Ying Chen, Yun Liu

Nomogram to predict overall survival for patients with non- metastatic cervical esophageal cancer: a SEER-based population study

Dezuo Dong, Dan Zhao, Shuai Li, Weixin Liu, Feng Du, Xiaolong Xu, Shaowen Xiao, Baomin Zheng, Yan Sun, Weihu Wang

Short-term dietary restriction ameliorates brain injury after cardiac arrest by modulation of mitochondrial biogenesis and energy metabolism in rats

Minggen Zhou, Tao Yu, Xiangshao Fang, Qiulin Ge, Fengqing Song, Zitong Huang, Longyuan Jiang, Peng Wang

Elevated lipoprotein(a) and risk of coronary heart disease according to different lipid profiles in the general Chinese community population: the CHCN-BTH study

Chunyue Guo, Han Cao, Guangliang Shan, Wei Zhao, Han Zhang, Kaijun Niu, Ze Cui, Naijun Tang, Kuo Liu, Li Pan, Xiaoyan Han, Zhengfang Wang, Ge Meng, Jixin Sun, Anqi Shan, Yuxiang Yan, Huijing He, Zhiyuan Xu, Yajing Cao, Wenjuan Peng, Yanyan Sun, Yunyi Xie, Xiaohui Liu, Bingxiao Li, Fuyuan Wen, Ling Zhang

Clinical findings in a group of COVID-19 patients: a single-center retrospective study

Fang Ji, Liang Wang, Chunyang Li, Liping Wang, Jungui Hao, Mingjia Dai, Yan Liu, Xiucheng Pan, Juanjuan Fu, Li Li, Guangde Yang, Jianye Yang, Xiao Zhang, Jiachuan Wang, Renhao Wang, Xuebing Yan, Bing Gu

Macrophage-derived netrin-1 contributes to endometriosis- associated pain

Shaojie Ding, Xinyue Guo, Libo Zhu, Jianzhang Wang, Tiantian Li, Qin Yu, Xinmei Zhang

Inhibition of laser induced rats choroidal neovascularization by intravitreous injection of sEphB4-HSA

Shikun He, Sha Ouyang, Xiaohua Li, Binyun Ma

Infection biomarkers in assisting the judgement of blood stream infection and patient prognosis: a retrospective study incorporating principal components analysis

Sheng Zhang, Xian Zhang, Wenbo Yu, Zhaofen Lin, Dechang Chen

Cross-sectional analysis of the association between serum uric acid levels and handgrip strength among Chinese adults over 45 years of age

Liqian Xu, Yuxia Jing, Chen Zhao, Yichen Yang, Ji Yang, Wenjing Zhou, Qin Zhang, Zhaodi Wang, Yunmei Yang

A multi-center study of prediction of macular hole status after vitrectomy and internal limiting membrane peeling by a deep learning model

Yijun Hu, Yu Xiao, Wuxiu Quan, Bin Zhang, Yuqing Wu, Qiaowei Wu, Baoyi Liu, Xiaomin Zeng, Ying Fang, Yu Hu, Songfu Feng, Ling Yuan, Tao Li, Hongmin Cai, Honghua Yu

Impact of anesthesia methods on perioperative systemic inflammation and long-term outcomes in patients undergoing surgery for hepatocellular carcinoma: a propensity score-matched analysis

Hao Zhang, Kefang Guo, Xingfeng Sun, Yi Liu, Ziwen Zhong, Wenchang Zhou, Weian Zeng, Lu Wang, Juan P. Cata, Wankun Chen, Changhong Miao

Predicting aggressive histopathological features in esophageal cancer with positron emission tomography using a deep convolutional neural network

Joe Chao-Yuan Yeh, Wei-Hsiang Yu, Cheng-Kun Yang, Ling-I Chien, Ko-Han Lin, Wen-Sheng Huang, Po-Kuei Hsu

Incidence and prognosis of undifferentiated cancers of the digestive system: a population-based cohort study

Jingping Qiu, Yan Xin

Automatic prediction of treatment outcomes in patients with diabetic macular edema using ensemble machine learning

Baoyi Liu, Bin Zhang, Yijun Hu, Dan Cao, Dawei Yang, Qiaowei Wu, Yu Hu, Jingwen Yang, Qingsheng Peng, Manqing Huang, Pingting Zhong, Xinran Dong, Songfu Feng, Tao Li, Haotian Lin, Hongmin Cai, Xiaohong Yang, Honghua Yu

Clinical results and complications associated with oblique lumbar interbody fusion technique

Cheng Cheng, Kai Wang, Can Zhang, Hao Wu, Fengzeng Jian

Endometrial cavity fluid is associated with deleterious pregnancy outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection: a retrospective cohort study

Wen Xiu Zhang, Lian Bao Cao, Ying Zhao, Jing Li, Bo Feng Li, Jia-Nan Lv, Lei Yan, Jin Long Ma

Poor consistency between reflux symptom index and laryngopharyngeal pH monitoring in laryngopharyngeal reflux diagnosis in Chinese population

Jun-Yao Wang, Tao Peng, Li-Li Zhao, Gui-Jian Feng, Yu-Lan Liu

Bone mineral density, osteopenia, osteoporosis, and fracture risk in patients with atopic dermatitis: a systematic review and meta- analysis

Di Wu, Xiang-Dong Wu, Xi Zhou, Wei Huang, Changqi Luo, Yong Liu

The trend of indirect anastomosis formation in a 2-vessel occlusion plus encephalo-myo-synangiosis rat model

Wensheng Li, Lei Wei, Bocheng Wang, Shuangqi Gao, Tengchao Huang, Zhangyu Li, Robin Bhattarai, Hui Wang, Ying Guo, Chuan Chen

Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes and preeclampsia

Congcong Liu, Jinsong Gao, Juntao Liu, Xietong Wang, Jing He, Jingxia Sun, Xiaowei Liu, Shixiu Liao

Intraoperative completion studies in carotid endarterectomy: systematic review and meta-analysis of techniques and outcomes

Christoph Knappich, Thomas Lang, Pavlos Tsantilas, Sofie Schmid, Michael Kallmayer, Bernhard Haller, Hans-Henning Eckstein

Prevalence and sex- and age-related risk of pulmonary embolism in inhospital patients with atrial fibrillation: a multicenter retrospective study from China

Ying Bai, Qiao-Min Yue, He Sun, Shi-Dong Guo, Zhen-Zhou Wang, Peng Zhong, Xue-Yao Wei, Lin Sun, Yue Liu, Xu-Bo Shi, Yan-Ting Liu

Rapid, accurate, multifunctional and self-assisted vision assessment and screening with interactive desktop autostereoscopy

Xiaoke Li, Jing Zhong, Yiyao Wang, Hantao Zhang, Jinrong Li, Kunyang Li, Li Gu, Min Zheng, Jin Yuan, Hang Fan, Dongyan Deng, Yao Wang, Jianying Zhou

A novel online calculator based on albumin-bilirubin and aspartate transaminase-to-platelet ratio index for predicting postoperative morbidity following hepatectomy for hepatocellular carcinoma

Li-Yang Sun, Hong Zhu, Yong-Kang Diao, Hao Xing, Lei Liang, Jie Li, Ya-Hao Zhou, Wei-Min Gu, Ting-Hao Chen, Yong-Yi Zeng, Timothy M. Pawlik, Wan Yee Lau, Chao Li, Feng Shen, Cheng-Wu Zhang, Tian Yang

Repressing PDCD4 activates JNK/ABCG2 pathway to induce chemoresistance to fluorouracil in colorectal cancer cells

Lanlin Hu, Yutong Liang, Kelv Wu, Caixia Wang, Tao Zhang, Rui Peng, Fangdong Zou

It’s not all about the size—characteristics and risk factors for malignancy of mucinous cystic neoplasms of the pancreas

Philipp Höhn, Muhammed Abdussamed Soydemir, Andreas Minh Luu, Monika Janot-Matuschek, Andrea Tannapfel, Waldemar Uhl, Orlin Belyaev

SPECTnet: a deep learning neural network for SPECT image reconstruction

Wenyi Shao, Steven P. Rowe, Yong Du

Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration

Un Chul Park, Susanna S. Park, Bo Hee Kim, Sung Wook Park, Young Joo Kim, Whitney Cary, Johnathon D. Anderson, Jan A. Nolta, Hyeong Gon Yu

The influence of initial defect morphology of alveolar ridge on volumetric change of grafted bone following guided bone regeneration in the anterior maxilla region: an exploratory retrospective study

Yuan Li, Xiao-Meng Zhang, Shu-Jiao Qian, Shi-Chong Qiao, Hong-Chang Lai, Jun-Yu Shi

Predictive factors of postoperative pancreatic fistula after laparoscopic pancreatoduodenectomy

Jikuan Jin, Guangbing Xiong, Jiali Li, Xingjun Guo, Min Wang, Zhen Li, Feng Zhu, Renyi Qin

The predictors and prognosis for unexpected reocclusion after mechanical thrombectomy: a meta-analysis

Xiangyu Li, Furong Gu, Jiayue Ding, Ji Bian, Na Wang, Rui Shu, Qingyun Li, Xiaolin Xu

Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4⁺ T-cell activation in a mouse heart transplantation model

Yajun Huang, Sufei Wang, Xiangchao Ding, Chuangyan Wu, Jiuling Chen, Zhiwei Hu, Xinling Du, Guohua Wang

Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury

Stephanie A. Savage, Ben L. Zarzaur, Greg E. Gaski, Tyler McCarroll, Ruben Zamora, Rami A. Namas, Yoram Vodovotz, Rachael A. Callcut, Timothy R. Billiar, Todd O. McKinley

miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1

Wenliang Tan, Zhirong Lin, Xianqing Chen, Wenxin Li, Sicong Zhu, Yingcheng Wei, Liyun Huo, Yajin Chen, Changzhen Shang

Prognostic factors for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome: a multicenter study in China

Haitao Shang, Tao Bai, Shenghua Zhu, Xiaoqian Yang, Chang Liu, Dong Xu, Yuzheng Zhuge, Yuhu Song, Xiaohua Hou

Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers

Qingting Huang, Jiyi Hu, Weixu Hu, Jing Gao, Jing Yang, Xianxin Qiu, Jiade Jay Lu, Lin Kong

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34+ bone marrow stem cells

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A. Nolta, Susanna S. Park

Sensitivity and specificity of combination of Hull airway reflux questionnaire and gastroesophageal reflux disease questionnaire in identifying patients with gastroesophageal reflux-induced chronic cough

Siwan Wen, Shengyuan Wang, Shanshan Niu, Mengru Zhang, Cuiqin Shi, Zhongmin Qiu, Xianghuai Xu, Li Yu

An overview of patients with urothelial bladder cancer over the past two decades: a Surveillance, Epidemiology, and End Results (SEER) study

Yan Zang, Xiao Li, Yifei Cheng, Feng Qi, Ningli Yang

Clinical implications of serum Mac-2-binding protein glycan isomer as a novel biomarker of advanced hepatic fibrosis in diabetes

Huiyul Park, Dae Won Jun, Hoon-Ki Park, Mimi Kim

Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study

Fei Han, Li-Xin Zhou, Jun Ni, Ming Yao, Fei-Fei Zhai, Yong-Tai Liu, Wei Wu, Hua-Dan Xue, Ming-Li Li, Meng Yang, Qing Dai, Li-Ying Cui, Zheng-Yu Jin, Yi-Cheng Zhu, Shu-Yang Zhang

Current situation and trends of online academic activities for oncologists during the COVID-19 pandemic: a multicenter survey

Fei Gao, Luopei Wei, Qichen Chen, Wen Shang, Zhuoyu Yang, Yan Wen, Shida Yan, Hanjie Hu, Rui Zhang, Ni Li, Hong Zhao

Uric acid preconditioning alleviated doxorubicin induced JNK activation and Cx43 phosphorylation associated cardiotoxicity via activation of AMPK-SHP2 signaling pathway

Jiawei Wang, Yixin Fan, Xiaomin Cai, Zhenzhen Gao, Zhengyi Yu, Bin Wei, Yulin Tang, Liang Hu, Wen-Tao Liu, Yanhong Gu

Association between comorbid diabetes mellitus and prognosis of patients with sepsis in the intensive care unit: a retrospective cohort study

Shan Lin, Shanhui Ge, Wanmei He, Mian Zeng

Hepatobiliary phase hypointensity on gadobenate dimeglumine- enhanced magnetic resonance imaging may improve the diagnosis of hepatocellular carcinoma

Yueming Li, Jianwei Chen, Shuping Weng, Chuan Yan, Rongping Ye, Yuemin Zhu, Liting Wen, Dairong Cao, Jinsheng Hong

Perfusion MR prior to radiotherapy is a strong predictor of survival in high-grade gliomas after proton and carbon ion radiotherapy

Xianxin Qiu, Jing Gao, Jing Yang, Jiyi Hu, Weixu Hu, Xiaoyong Zhang, Jiade J. Lu, Lin Kong

Perception of femininity and attractiveness in Facial Feminization Surgery

Ann Hui Ching, Allister Hirschman, Xiaona Lu, Seija Maniskas, Antonio J. Forte, Michael Alperovich, John A. Persing

Pre-treatment FLT-PET parameters as a prognostic tool for patients with locally advanced recurrent nasopharyngeal carcinoma salvaged by carbon-ion radiotherapy: a pilot study

Jiyi Hu, Zhongyi Yang, Jing Gao, Weixu Hu, Jing Yang, Xianxin Qiu, Guang Ma, Lin Kong, Jiade J. Lu

Association of lymphocyte count and incidence of maternal fever in epidural analgesia-involved labor

Jing Chai, Lijie Jia, Huimin Cao, Xiaoyu Zhang, Zifeng Xu

Metformin inhibits inflammation and bone destruction in collagen- induced arthritis in rats

Kai-Jian Fan, Jing Wu, Qi-Shan Wang, Bing-Xin Xu, Fu-Tao Zhao, Ting-Yu Wang

Diagnosis and management of protracted bacterial bronchitis: a survey of Chinese pediatricians

Qinyuan Li, Ziyao Guo, Yuanyuan Li, Guangli Zhang, Xiaoyin Tian, Ruixue Gu, Zhengxiu Luo

Comparison of different surgical interventions for hepatocellular carcinoma with bile duct tumor thrombus: a systematic review and meta-analysis

Jin-Kai Feng, Zhen-Hua Chen, Yu-Xuan Wu, Kang Wang, Ju-Xian Sun, Zong-Tao Chai, Wei-Xing Guo, Jie Shi, Shu-Qun Cheng

Association of a novel PKHD1 mutation in a family with autosomal dominant polycystic liver disease

Jiaru Wang, Huayu Yang, Ruohan Guo, Xinting Sang, Yilei Mao

Coronary artery disease: differential expression of ceRNAs and interaction analyses

Sheng Kang, Yong Ye, Guang Xia, Hai-Bo Liu

No diffuse intrahepatic biliary stricture after ABO-incompatible adult living donor liver transplantation using tailored rituximab-based desensitization protocol

Koji Natsuda, Takahiro Murokawa, Kwang-Woong Lee, Kyung Chul Yoon, Suk Kyun Hong, Jeong-Moo Lee, Jae-Hyung Cho, Nam-Joon Yi, Kyung-Suk Suh

Significance of endometrial thickness change after human chorionic gonadotrophin triggering in modified natural cycles for frozen-thawed embryo transfer

Jialyu Huang, Jiaying Lin, Renfei Cai, Xuefeng Lu, Ning Song, Hongyuan Gao, Yanping Kuang

Review Article

Detection and significance of glial fibrillary acidic protein antibody in autoimmune astocytopathy and related diseases

Jiehong Huang, Wenyao Huang, Ruisi Zhou, Wenhui Lin, Ting Chen, Youming Long

Metal-on-metal (MoM) hip implants and pregnancy: are MoM implants good for mom?—a systematic review

Linsen T. Samuel, Jacob M. Rabin, Nicholas R. Arnold, Mohammed Munim, Peter J. Brooks, Michael A. Mont

Serological diagnosis of myasthenia gravis and its clinical significance

Yi Li, Yuyao Peng, Huan Yang

Human placental extract: a potential therapeutic in treating osteoarthritis

Chukwuweike Gwam, Chiemena Ohanele, Jacob Hamby, Noor Chughtai, Zarmina Mufti, Xue Ma

Progress in the esophagogastric anastomosis and the challenges of minimally invasive thoracoscopic surgery

Luigi Bonavina

The modern approach to esophagectomy—review of the shift towards minimally invasive surgery

Daniel P. Dolan, Scott J. Swanson

Endometriosis and ovarian cancer risk, an epigenetic connection

Sarah Brunty, Brenda Mitchell, Nadim Bou-Zgheib, Nalini Santanam

Current state of navigation in spine surgery

Nathaniel Rawicki, James E. Dowdell, Harvinder S. Sandhu

Intraoperative image guidance for cervical spine surgery

Sertac Kirnaz, Harry Gebhard, Taylor Wong, Raj Nangunoori, Franziska Anna Schmidt, Kosuke Sato, Roger Härtl

Intraoperative image guidance for lateral position surgery

Peter R. Swiatek, Michael H. McCarthy, Joseph Weiner, Shivani Bhargava, Avani S. Vaishnav, Sravisht Iyer

Narrative review: the holy grail: update on pharmacotherapy for heart failure with preserved ejection fraction

Pablo Alejandro Paz, Barbara Daniela Mantilla, Erwin E. Argueta, Debabrata Mukherjee

Inhaled antibiotics during mechanical ventilation—why it will work

Maxime Desgrouas, Stephan Ehrmann

Narrative review in the current role of angiotensin receptor-neprilysin inhibitors

Jose B. Cruz Rodriguez, Cameron Cu, Tariq Siddiqui

Guidelines on prosthetic heart valve management in infective endocarditis: a narrative review comparing American Heart Association/American College of Cardiology and European Society of Cardiology guidelines

Umberto Maria Satriano, Antonio Nenna, Cristiano Spadaccio, Francesco Pollari, Theodor Fischlein, Massimo Chello, Francesco Nappi

Non-alcoholic fatty liver diseases: current challenges and future directions

Elke Roeb

The CLASI, a validated tool for the evaluation of skin disease in lupus erythematosus: a narrative review

Srita Chakka, Rebecca L. Krain, Josef Symon S. Concha, Benjamin F. Chong, Joseph F. Merola, Victoria P. Werth

Review of aerosol delivery in the emergency department

Patricia A. Dailey, Courtney M. Shockley

Narrative review of the choices of stem cell sources and hydrogels for cartilage tissue engineering

Zhantao Deng, Jiewen Jin, Shuai Wang, Fangjie Qi, Xuepan Chen, Chang Liu, Yanbing Li, Yuanchen Ma, Fengjuan Lyu, Qiujian Zheng

Subcellular microRNAs in diabetic cardiomyopathy

Huaping Li, Jiahui Fan, Chen Chen, Dao Wen Wang

Extreme complications related to bevacizumab use in the treatment of ovarian cancer: a case series from a III level referral centre and review of the literature

Luigi Carlo Turco, Gabriella Ferrandina, Virginia Vargiu, Serena Cappuccio, Anna Fagotti, Giuseppina Sallustio, Giovanni Scambia, Francesco Cosentino

The modern approach to esophageal palliative and emergency surgery

Anny Godin, Moishe Liberman

The current state of navigation in robotic spine surgery

Meng Huang, Tyler A. Tetreault, Avani Vaishnav, Philip J. York, Blake N. Staub

Intraoperative risks of radiation exposure for the surgeon and patient

Nathaniel W. Jenkins, James M. Parrish, Evan D. Sheha, Kern Singh

Fugitive aerosols in the intensive care unit: a narrative review

Ciarraí O’Toole, Mary Joyce, James A. McGrath, Andrew O’Sullivan, Miriam A. Byrne, Ronan MacLoughlin

Nipple-areola complex reconstruction in transgender patients undergoing mastectomy with free nipple grafts: a systematic review of techniques and outcomes

Samyd S. Bustos, Doga Kuruoglu, Maria Yan, Valeria P. Bustos, Antonio J. Forte, Pedro Ciudad, Esther A. Kim, Gabriel A. Del Corral, Oscar J. Manrique

A management framework for left sided endocarditis: a narrative review

Francesco Nappi, Cristiano Spadaccio, Marc R. Moon

It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis

Amit Khurana, Nilofer Sayed, Prince Allawadhi, Ralf Weiskirchen

A narrative review of diagnosis of infective endocarditis—imaging methods and comparison

Sanjeet Singh Avtaar Singh, Marco Fabio Costantino, Gianpaolo D’Addeo, Damiano Cardinale, Rosario Fiorilli, Francesco Nappi

Splenic trauma: endovascular treatment approach

Maxwell Cretcher, Catherine E. P. Panick, Alexander Boscanin, Khashayar Farsad

Paraesophageal hernia: to fundoplicate or not?

Daniel Solomon, Eliahu Bekhor, Hanoch Kashtan

Narrative review on serous primary peritoneal carcinoma of unknown primary site: four questions to be answered

Elie Rassy, Tarek Assi, Stergios Boussios, Joseph Kattan, Julie Smith-Gagen, Nicholas Pavlidis

Acute traumatic injury of the aorta: presentation, diagnosis, and treatment

S. Rodes Brown, Sasha A. Still, Kyle W. Eudailey, Adam W. Beck, Andrew J. Gunn

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues

Rolf Teschke, Jack Uetrecht

Hyperthermic intraperitoneal chemotherapy in ovarian cancer: Qui Bono?

John Spiliotis

Intranasal drugs for analgesia and sedation in children admitted to pediatric emergency department: a narrative review

Valeria Pansini, Antonietta Curatola, Antonio Gatto, Ilaria Lazzareschi, Antonio Ruggiero, Antonio Chiaretti

A narrative review of early surgery versus conventional treatment for infective endocarditis: do we have an answer?

Umberto Benedetto, Cristiano Spadaccio, Federico Gentile, Marc R. Moon, Francesco Nappi

Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

Sangwan Park, Brian C. Leonard, Vijay Krishna Raghunathan, Soohyun Kim, Jennifer Y. Li, Mark J. Mannis, Christopher J. Murphy, Sara M. Thomasy

Diagnostic management of nonalcoholic fatty liver disease: a transformational period in the development of diagnostic and predictive tools—a narrative review

Natalia Rosso, Adam M. Stephenson, Pablo J. Giraudi, Claudio Tiribelli

Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction

Vaia Florou, Sonam Puri, Ignacio Garrido-Laguna, Breelyn A. Wilky

Manometric pattern progression in esophageal achalasia in the era of high-resolution manometry

Renato Salvador, Mario Costantini, Salvatore Tolone, Pietro Familiari, Ermenegildo Galliani, Bastianello Germanà, Edoardo Savarino, Stefano Merigliano, Michele Valmasoni

Upfront debulking surgery for high-grade serous ovarian carcinoma: current evidence

Orestis Tsonis, Fani Gkrozou, Konstantinos Vlachos, Minas Paschopoulos, Michail C. Mitsis, Nikolaos Zakynthinakis-Kyriakou, Stergios Boussios, George Pappas-Gogos

Ovarian cancer risk assessment in the era of next-generation sequencing

Renata Colombo Bonadio, Jéssica Rojas Crespo, Maria Del Pilar Estevez-Diz

Robotics and minimally invasive esophageal surgery

Ealaf Shemmeri, Jon O. Wee

Pulmonary vasodilator use in continuous-flow left ventricular assist device management

Preethi Pirlamarla, Eduardo Rame, Charles Hoopes, Indranee Rajapreyar

Environmental triggers of dermatomyositis: a narrative review

Christina E. Bax, Spandana Maddukuri, Adarsh Ravishankar, Lisa Pappas-Taffer, Victoria P. Werth

A path to successful patient outcomes through aerosol drug delivery to children: a narrative review

Arzu Ari

Human cutaneous B cells: what do we really know?

Irina Lerman, Drew C. Mitchell, Christopher T. Richardson

Narrative Review of Carotid disease and the kidney

Luca Zanoli, Dimitri P. Mikhailidis

A narrative review of gallbladder adenomyomatosis: what we need to know

Kit-Fai Lee, Esther H. Y. Hung, Howard H. W. Leung, Paul B. S. Lai

Aerosol delivery via noninvasive ventilation: role of models and bioanalysis

Haitham Saeed, Hadeer S. Harb, Yasmin M. Madney, Mohamed E. A. Abdelrahim

A narrative review of risk factors and interventions for cancer- related cognitive impairment

Lu Bai, Enyan Yu

The dark side of immunotherapy

Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami

Evolving treatment paradigms in esophageal cancer

Ilit Turgeman, Irit Ben-Aharon

Opioid transdermal delivery system: a useful method for pain management in children

Stefano Mastrangelo, Michele Antonio Capozza, Silvia Triarico, Giorgio Attinà, Palma Maurizi, Alberto Romano, Antonio Ruggiero

Neoadjuvant treatment for newly diagnosed advanced ovarian cancer: where do we stand and where are we going?

Michele Moschetta, Stergios Boussios, Elie Rassy, Eleftherios P. Samartzis, Gabriel Funingana, Mario Uccello

Current and future immunotherapy approaches in ovarian cancer

Nazım Can Demircan, Stergios Boussios, Tolga Tasci, Mehmet Akif Öztürk

Intraoperative image guidance for endoscopic spine surgery

Jason I. Liounakos, Gregory W. Basil, Hikari Urakawa, Michael Y. Wang

Measurements of deposited aerosol dose in infants and small children

Timothy E. Corcoran

Administration of dry powders during respiratory supports

Wei-Ren Ke, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Patricia Tang, Lan Chen, Donghao Chen, Hak-Kim Chan

Antiplatelet and anticoagulation strategies for left ventricular assist devices

Renzo Y. Loyaga-Rendon, Toshinobu Kazui, Deepak Acharya

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Frank Tacke, Ralf Weiskirchen

Therapeutic strategies in Wilson disease: pathophysiology and mode of action

Wolfgang Stremmel, Ralf Weiskirchen

Targeting vascular endothelial growth factor using retinal gene therapy

Sook H. Chung, Sonia L. Frick, Glenn Yiu

A narrative review of non-pharmacological management of SARS-CoV-2 respiratory failure: a call for an evidence based approach

Rishik Vashisht, Sudhir Krishnan, Abhijit Duggal

Gene therapy for inherited retinal diseases

Yan Nuzbrokh, Sara D. Ragi, Stephen H. Tsang

Development of new poly(ADP-ribose) polymerase (PARP) inhibitors in ovarian cancer: Quo Vadis?

Stergios Boussios, Michele Moschetta, Peeter Karihtala, Eleftherios P. Samartzis, Matin Sheriff, George Pappas-Gogos, Mehmet Akif Ozturk, Mario Uccello, Afroditi Karathanasi, Michail Tringos, Elie Rassy, Nicholas Pavlidis

Metformin and ovarian cancer: the evidence

Elina Urpilainen, Ulla Puistola, Stergios Boussios, Peeter Karihtala

Preoperative planning for intraoperative navigation guidance

Shahbaaz A. Sabri, Philip J. York

Intraoperative image guidance for the surgical treatment of adult spinal deformity

Venkat Boddapati, Joseph M. Lombardi, Hikari Urakawa, Ronald A. Lehman

Sharing of decision-making for infective endocarditis surgery: a narrative review of clinical and ethical implications

Francesco Pollari, Cristiano Spadaccio, Michela Cuomo, Massimo Chello, Antonio Nenna, Theodor Fischlein, Francesco Nappi

Current practices on genetic testing in ovarian cancer

Florentia Fostira, Marios Papadimitriou, Christos Papadimitriou

Narrative review of pharmacotherapy for transthyretin cardiac amyloid

Jose B. Cruz Rodriguez, Jose A. Tallaj

Inhaled pulmonary vasodilators: a narrative review

Kai Liu, Huan Wang, Shen-Ji Yu, Guo-Wei Tu, Zhe Luo

Dairy consumption and hepatocellular carcinoma risk

Bodo C. Melnik

Esophageal disease in lung transplant patients

John S. Young, Antonio Coppolino

Systemic anti-cancer treatment in malignant ovarian germ cell tumours (MOGCTs): current management and promising approaches

Mario Uccello, Stergios Boussios, Eleftherios P. Samartzis, Michele Moschetta

New frontiers in esophageal radiology

Eric J. Schmidlin, Ritu R. Gill

Current innovation in virtual and augmented reality in spine surgery

Frank J. Yuk, Georgios A. Maragkos, Kosuke Sato, Jeremy Steinberger

The quest for the optimal surgical management of tricuspid valve endocarditis in the current era: a narrative review

Francesco Nappi, Cristiano Spadaccio, Christos Mihos, Kasra Shaikhrezai, Christophe Acar, Marc R. Moon

A narrative review of the interpretation of guidelines for the treatment of infective endocarditis

Umberto Benedetto, Sanjeet Singh Avtaar Singh, Cristiano Spadaccio, Marc R. Moon, Francesco Nappi

Endovascular embolization in renal trauma: a narrative review

Tyler Andrew Smith, Adriene Eastaway, Duncan Hartt, Keith Bertram Quencer

Narrative review of intrathecal drug delivery (IDD): indications, devices and potential complications

Michele Antonio Capozza, Silvia Triarico, Stefano Mastrangelo, Giorgio Attinà, Palma Maurizi, Antonio Ruggiero

The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis—a narrative review article

Wolfgang Stremmel, Martina Lukasova, Ralf Weiskirchen

Narrative review of vascular iatrogenic trauma and endovascular treatment

Tyler Andrew Smith, David Gage, Keith Bertram Quencer

De-intensification strategies in HPV-related oropharyngeal squamous cell carcinoma—a narrative review

Madeleine P. Strohl, Katherine C. Wai, Patrick K. Ha

The role of bile acids in cholestatic liver injury

Shi-Ying Cai, James L. Boyer

Fluorescence-guided surgery of the esophagus

Paul Chandler, Ory Wiesel, Danny A. Sherwinter

Pain assessment in clinical trials: a narrative review

Livia Puljak, Krste Boric, Svjetlana Dosenovic

Narrative review of intraoperative image guidance for transforaminal lumbar interbody fusion

Joseph A. Weiner, Michael H. McCarthy, Peter Swiatek, Philip K. Louie, Sheeraz A. Qureshi

Redo aortic valve replacement for prosthesis endocarditis in patients previously classified as high or prohibitive risk: a narrative review

Francesco Pollari, Renate Ziegler, Francesco Nappi, Irena Großmann, Jörg Steinmann, Theodor Fischlein

Optimal diuretic strategies in heart failure

Sarabjeet S. Suri, Salpy V. Pamboukian

Updates in pharmacotherapy of heart failure with reduced ejection fraction

Clifton Espinoza, Haider Alkhateeb, Tariq Siddiqui

Circulating tumor DNA-based predictive biomarkers in breast cancer clinical trials: a narrative review

Oraianthi Fiste, Michael Liontos, Konstantinos Koutsoukos, Evangelos Terpos, Meletios A. Dimopoulos, Flora Zagouri

Erratum

Erratum to development and formulation of the classification criteria for osteoarthritis

Cibo Huang, Zhiyi Zhang, Yaolong Chen, Yue Zhang, Dan Xing, Like Zhao, Jianhao Lin, Yifang Mei, Hsiao-Yi Lin, Yi Zheng, Wei-Chung Tsai, Shengyun Liu, Quan Jiang, Yi Liu, Jinwei Chen, Zhizhong Ye, Min Chen, Yingjuan Chen, Cong-Qiu Chu, Ming Gao, Lan He, Jin Lin, Lijun Wu, Jianhua Xu, Pinting Yang, Xuewu Zhang, Qing Jiang, Guanghua Lei, Mengtao Li, Wanling Yang, Xin Gu, Yixin Zhou, Dongyi He, Wei Liu, Weiya Zhang, Changhai Ding, Xiaofeng Zeng, on behalf of the COACH Group

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Annals of Translational Medicine is an international, peer-reviewed Open Access journal featuring original and observational investigations in the broad fields of laboratory, clinical, and public health research including but are not limited to, oncology, thoracic disease, cardiology, hepatology, gastroenterology, endocrinology, neurology, dermatology, biomedical engineering, biochemical science/genomics, pathology, medical informatics, emergency medicine/critical care, epidemiology, hematology, immunology, drug, and other interdisciplinary approaches to medicine.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in... More >>

What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz More >>

Lawrence A. Lavery More >>

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