Home - Annals of Translational Medicine

Focus on “Translational approach to investigation of solid tumor malignancies” edited by Dr. Emil Lou

Articles from these leading researchers, taken together, effectively paint the picture on a wide canvas and shine a spotlight on critical issues facing the translational oncology community. These leading experts provide a state-of-the-art assessment of timely questions spanning cancer research, from bedside to clinic (and back), including but not limited to accurate molecular assessment of genomic profiles, predictive and prognostic biomarkers, determination of appropriate treatments based on economic profiles, and also the financial toxicity stemming from the recent new wave of effective but expensive cancer-targeting therapies in lung cancer, breast cancer, colorectal cancer, and prostate cancer.

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through Innovation” edited by Dr. Giannis Mountzios

Lung cancer remains the leading cause of cancer related death worldwide, with approximately 1.6 million deaths recorded in 2015. Non-small cell lung cancer (NSCLC) accounts for approximately 80–85% of cases. Despite broad advances in diagnostics and therapy, the 5-year overall survival for patients with advanced NSCLC has not significantly changed over the past few years. Following the decoding of human cancer genome and the advent of therapies targeting driver mutations, the choice of systemic therapy changed from “one size fits all” approach to a more precise selection of biologic therapies targeting distinct genetic profiles, the so-called “precision” medicine.

Focus on “Art of Minimally Invasive Spine Surgery” edited by Dr. Roger Härtl and Dr. Ai-Min Wu

This special issue reports the newest MISS techniques in the treatment of a wide spectrum of spinal disorders. This timely issue will be extremely useful to spine surgeons, orthopedic surgeons, neurological surgeons, and young scientists who are interested in MISS. As MISS is still in its evolution, we also hope that this issue can bring some inspiration to readers to contribute to its progress.

Join us at the 26th ESTS Annual Meeting, 27-30 May 2018, Ljubljana, Slovenia!

The 26th European Society of Thoracic Surgeons (ESTS) Annual Meeting is going to be held during 27-30 May 2017, Ljubljana, Slovenia. The AME Editorial Team is glad to attend the conference to exhibit our books and journals like the Journal of Visualized Surgery (JOVS), Journal of Thoracic Disease (JTD), Video-assisted Thoracic Surgery (VATS), etc, at the booth (named “AME Publishing Company”, at No. 38). We would like to seize this great opportunity to meet our authors, editorial board members and readers.

Join us at AIMed Europe, London 11-13 September 2018 + Datathon sponsored by Google Cloud

Find out more about the role AI has to play in our future at the AIMed Europe conference in London on 11-13 September. This is the largest and most comprehensive multi-disciplinary AI in healthcare and medical conference in Europe.

AIMed Europe is an engaging, strategic-level platform for clinicians, physicians, CIOs and CMIOs, Data and Computer Scientists, Investors and Entrepreneurs.

The conference will take place over 5 days and include for the first time, a Datathon - Sponsored by Google Cloud

www.aimed.events/europe

Together we witness the 5th AME journal indexed in SCIE: Annals of Translational Medicine!

Good news continues to roll in! Announced by Clarivate Analytics, former Thomson Reuters Intellectual Property and Science Business, Annals of Translational Medicine (known as ATM), under AME Publishing Company, is officially indexed in Science Citation Index Expanded (SCIE) on 02 March, 2018

2017 Annual Report of ATM

We are glad to present the 2017 Annual Report of ATM here. In 2017, ATM progressed fast and smoothly under the join-efforts of experts worldwide. The total citation number has significantly increased from 1294 in January to 3314 in December. The journal was also exhibited in some international meetings, to attract wider attention and exposure. More information is shown in the Annual Report.
We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy, healthy and prosperous 2018!

Artificial Intelligence (AI) in Medicine: Evolving with the Times

The Annals of Translational Medicine (ATM) is putting up a call for new research and innovative ideas on the study of AI in medicine. Regarded as one of the hottest topics that the ATM is placing a huge focus on, all authors and articles are provided a spotlight to showcase their knowledge and studies with other experts. Interested authors may join the editorial board in leading special issues focusing on medical AI, or submit articles that demonstrate novelty in method and theory related to AI and computer science techniques. Any suggestions or ideas of medical AI topics that may spark debate and discussion are also welcome.

Rare diseases: exploration never ceases

Despite occurrence over a small percentage of the population, rare diseases are often chronic and life-threatening. Around five new rare diseases are described in medical literature every week. Attention to the special challenges faced by these patients has been sought internationally by an annual Rare Disease Day on the last day of each February.

In view of the elevating awareness and concern over the management of these diseases, Annals of Translational Medicine now opens new grounds for the studies of rare diseases. Any articles that encourage new understanding, solid theory, debate, controversy and reflection on any kind of rare diseases are welcome.

Testimonials for ATM from Eminent Experts Worldwide

ATM has received over 35 supporting letters from prominent experts worldwide, who are editorial board members, guest editors, authors and readers knowing ATM well. We are sincerely grateful for their approval and vigorous support to the journal. The editorial office will keep moving on to build ATM a robust academic platform in near future. Below abstracts some parts from their supporting letters.

Impact of sleep apnea on in-hospital outcomes after transcatheter aortic valve replacement: insight from National Inpatient Sample database 2011–2014

Sleep apnea is associated with worse outcomes following various kinds of surgeries. There is a paucity of data on the association of sleep apnea with clinical outcomes after transcatheter aortic valve replacement (TAVR).

MDA5 autoantibody—another indicator of clinical diversity in dermatomyositis

Allenbach and colleagues have recently reported for the first time the results of an intriguing study of the histopathologic, immunopathologic and gene expression differences in muscle biopsy tissue from adult dermatomyositis (DM) patients who do and do not have circulating MDA5 autoantibodies (anti-MDA5). Anti-MDA5 were originally identified in a clinically-defined subset of DM patients whose disease was expressed predominately in the skin for unusually long periods of time without accompanying muscle weakness [i.e., “clinically-amyopathic DM” (CADM)] and were at risk for acute, rapidly-progressive form of interstitial lung disease (ILD)...

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Vol 6, No 11 (June, 2018)

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Focused Issues more

Focus on “Translational approach to investigation of solid tumor malignancies” More >>

Focus on “Breakthroughs in the Treatment of Advanced Lung Cancer: Making Progress Through... More >>

Focus on “Art of Minimally Invasive Spine Surgery” More >>

Endorsement

Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.

the Brazilian Society of Thoracic Surgery(SBCT)

the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article

Blood pressure targets for hypertension in patients with type 2 diabetes

Wilbert S. Aronow, Tatyana A. Shamliyan

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Trends of snowboarding-related fractures that presented to emergency departments in the United States, 2010 to 2016

Aleksey Seleznev, Neil V. Shah, Rohan Desai, Cuong Le, Patrick Cleary, Qais Naziri, Niladri N. Basu, Barbara J. Freeman, William P. Urban, Jared M. Newman

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The efficacy of first-line chemotherapy in recurrent or metastatic nasopharyngeal carcinoma: a systematic review and metaanalysis

Shu-Xiang Ma, Ting Zhou, Yan Huang, Yun-Peng Yang, Jian-Hua Zhan, Ya-Xiong Zhang, Zhong-Han Zhang, Yuan-Yuan Zhao, Wen-Feng Fang, Yu-Xiang Ma, Li-Kun Chen, Hong-Yun Zhao, Li Zhang

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Cervical or thoracic anastomosis for patients with cervicothoracic esophageal squamous cell carcinoma

Ran Mo, Chen Chen, Liang Pan, Ao Yu, Tao Wang

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Compensatory hyperhidrosis after different surgeries at the same sympathetic levels: a meta-analysis

Xiaojun Du, Xu Zhu, Tao Wang, Xiao Hu, Peng Lin, Yin Teng, Chao Fan, Jianglun Li, Yang Xi, Jiarong Xiao, Wen Liu, Jian Zhang, Haiyu Zhou, Dan Tian, Shizhang Yuan

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Short-term outcomes for total knee arthroplasty patients with active extension lag

Tanner L. McGinn, Jennifer I. Etcheson, Chukwuweike U. Gwam, Nicole E. George, Nequesha S. Mohamed, Jaydev B. Mistry, Ugochi Ananaba, Anil Bhave

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Physical activity levels are low in patients with pulmonary hypertension

Laura González-Saiz, Alejandro Santos-Lozano, Carmen Fiuza-Luces, Paz Sanz-Ayán, Carlos A. Quezada-Loaiza, Ana Ruiz-Casado, Lidia B. Alejo, Angela Flox-Camacho, María Morán, Alejandro Lucia, Pilar Escribano-Subías

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Impact of polymyxin B hemoperfusion in the treatment of patients with sepsis and septic shock: a meta-analysis of randomized controlled trials

Akira Kuriyama, Morihiro Katsura, Seigo Urushidani, Tadaaki Takada

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Increasing clinical resistance rate of Shigella sonnei to cefotaxime in Jiangsu Province, China, between 2012 and 2015

Huimin Qian, Guoye Liu, Yin Chen, Ping Ma, Xiaoxiao Kong, Lu Zhou, Jie Hong, Changjun Bao, Bing Gu

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Study on factors affecting local peak strain results in automatic functional imaging of transthoracic echocardiography

Na Li, Linbin Meng, Yichen Wang, Kailing Xiong, Junxuan He, Yang Wang, Yifu Qiao, Attila Nemes, Raffaele Giordano, Lang Qiao, written on behalf of AME Echocardiography Collaborative Group

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miR-486 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells

Jin Li, Qiulian Zhou, Yajun Liang, Wen Pan, Yihua Bei, Yuhui Zhang, Jinhua Wang, Zheng Jiao

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Review Article

Surgery for intrathoracic tracheoesophageal and bronchoesophageal fistula

Benoit Jacques Bibas, Paulo Francisco Guerreiro Cardoso, Helio Minamoto, Paulo Manoel Pêgo-Fernandes

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Case Report

Laparoscopic Roux-en-Y duodenojejunostomy for annular pancreas in adults: case report and literature review

He Cai, Xin Wang, Yun-Qiang Cai, Yong-Bin Li, Ling-Wei Meng, Bing Peng

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Pulmonary sequestration associated with a synchronous elevation of carbohydrate antigen 50 and 19-9: a case report

Shaozi Fu, Haitao Wang

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Laparoscopic pancreaticoduodenectomy with major venous resection and reconstruction with repassed round ligament: a case report

Yunqiang Cai, Yongbin Li, Pan Gao, Xin Wang, Bing Peng

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Surgical Technique

Development and clinical applications of glasses-free three-dimensional (3D) display technology for thoracoscopic surgery

Jun Liu, Fei Cui, Jingpei Li, Wenlong Shao, Wei Wang, Jun Li, Muchun Liu, Jianxing He

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Technical Note

Laparoscopic suture training curricula and techniques

Xin Wang, Yongbin Li, Yunqiang Cai, Lingwei Meng, He Cai, Xubao Liu, Bing Peng

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Big-data Clinical Trial Column

Opening the black box of neural networks: methods for interpreting neural network models in clinical applications

Zhongheng Zhang, Marcus W. Beck, David A. Winkler, Bin Huang, Wilbert Sibanda, Hemant Goyal, written on behalf of AME Big-Data Clinical Trial Collaborative Group

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Column in Changemakers in Patient-Oriented Translational Clinical Investigation

James Neil Gilliam, MD—the career arc of a patient-oriented translational clinical investigation changemaker in rheumatologic skin disease

Richard D. Sontheimer

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Editorial

Aspirin and diabetes mellitus in primary prevention: the Endless Conundrum

Rubén Casado-Arroyo

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Low-dose aspirin for primary cardiovascular prevention in diabetic patients: the issue to believe it or not

Priscilla Lamendola, Angelo Villano, Augusto Fusco, Massimo Leggio

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Quality of life and treatment satisfaction are highly relevant patient-reported outcomes in type 2 diabetes mellitus

Didac Mauricio

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Multi-drug therapy in breast cancer: are there any alternatives?

Partha Mitra

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Which criteria should we use to evaluate the efficacy of immunecheckpoint inhibitors?

Yuki Kataoka, Katsuya Hirano

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An important piece of the puzzle for understanding the benefits of concomitant ablation of atrial fibrillation in cardiac surgery

Anders Albåge

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Policy and governance solutions for ensuring equitable access to cancer medicines in low- and middle-income countries

Raphael E. Cuomo, Tim K. Mackey

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The uremic solute-AHR-tissue factor axis in vascular cells, mouse models and thrombosis in chronic kidney disease patients

Nigel Mackman, Jonathan H. Erlich

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Is effective the hyperbaric oxygen therapy for the treatment of ischemic lower extremity ulcers?—new insights from a multicenter study

Bruno Rivas-Santiago

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Building a cultural alliance for the prevention of fragility fractures among high risk older adults

Marta Baroni, Valentina Prenni, Carmelinda Ruggiero

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Hyperbaric oxygen for treatment of diabetic foot ulcers: love you more than I can say

Qinan Wu

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Optimal regimen of cisplatin in squamous cell carcinoma of head and neck yet to be determined

Xiuning Le, Ehab Y. Hanna

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Gene-expression signature may be useful for the prediction of lymph node metastasis in esophageal cancer

Yoshifumi Baba, Hideo Baba

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The search for surrogate endpoints for immunotherapy trials

Marc Buyse, Tomasz Burzykowski, Everardo D. Saad

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BLU-285—the breakthrough in treatment of patients with aggressive systemic mastocytosis and gastrointestinal stromal tumor

Regine Schneider-Stock

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Noninvasive cancer biomarkers in solid malignancies: circulating tumor DNA—clinical utility, current limitations and future perspectives

Debora de Melo Gagliato, Denis L. Fontes Jardim

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Unmask the genetic backbone of ibrutinib-relapsed chronic lymphocytic leukemia progression and Richter transformation

Wei-Ge Wang, Xiao-Yan Zhou, Xiao-Qiu Li

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The promise and challenges of chimeric antigen receptor T cells in relapsed B-cell acute lymphoblastic leukemia

Zhi-Chun Ding

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Different prevalence and clinical outcome of Epstein-Barr virus positive diffuse large B-cell lymphoma between North American and non-Western populations

Lihui Yin, Zijun Y. Xu-Monette, Jay Brock, Yong Li, Ken H. Young

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Revolutionary changes in salvage treatment for Hodgkin lymphoma: toward a chemotherapy-free future

Jiawen Chen, Wei Yang, Zimu Gong

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Is there a place for the combination of brentuximab vedotin and bendamustine in treatment of patients with relapsed/refractory Hodgkin lymphoma?

Robert W. Chen

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Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Additional data in the debate on stage I non-small cell lung cancer: surgery versus stereotactic ablative radiotherapy

Charles B. Simone II, Jay F. Dorsey

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Marius Ilie, Véronique Hofman, Elodie Long, Olivier Bordone, Eric Selva, Kevin Washetine, Charles Hugo Marquette, Paul Hofman

Clinical advances in the development of novel VEGFR2 inhibitors

Caterina Fontanella, Elena Ongaro, Silvia Bolzonello, Michela Guardascione, Gianpiero Fasola, Giuseppe Aprile

Recent advances in the development of farnesoid X receptor agonists

Ahmad H. Ali, Elizabeth J. Carey, Keith D. Lindor

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations

Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri, Wainer Zoli, Michel Rigaud

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

CTC enumeration and characterization: moving toward personalized medicine

Angela Toss, Zhaomei Mu, Sandra Fernandez, Massimo Cristofanilli

Current trends in the surgical management and treatment of adult glioblastoma

Richard M. Young, Aria Jamshidi, Gregory Davis, Jonathan H. Sherman

Metformin may function as anti-cancer agent via targeting cancer stem cells: the potential biological significance of tumorassociated miRNAs in breast and pancreatic cancers

Bin Bao, Asfar S. Azmi, Shadan Ali, Feras Zaiem, Fazlul H. Sarkar

Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification

Krishanthan Vigneswaran, Stewart Neill, Costas G. Hadjipanayis

Lung cancer epidemiology: contemporary and future challenges worldwide

Joanna Didkowska, Urszula Wojciechowska, Marta Mańczuk, Jakub Łobaszewski

Immune checkpoint inhibitors: therapeutic advances in melanoma

Ivan Márquez-Rodas, Pablo Cerezuela, Ainara Soria, Alfonso Berrocal, Aldo Riso, María González-Cao, Salvador Martín-Algarra

Structural analysis of glucans

Andriy Synytsya, Miroslav Novak

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

“Liquid biopsy”—ctDNA detection with great potential and challenges

Mingwei Ma, Hongcheng Zhu, Chi Zhang, Xinchen Sun, Xianshu Gao, Gang Chen

Roscovitine in cancer and other diseases

Jonas Cicenas, Karthik Kalyan, Aleksandras Sorokinas, Edvinas Stankunas, Josh Levy, Ingrida Meskinyte, Vaidotas Stankevicius, Algirdas Kaupinis, Mindaugas Valius

Resistant mechanisms to BRAF inhibitors in melanoma

José Luís Manzano, Laura Layos, Cristina Bugés, María de los Llanos Gil, Laia Vila, Eva Martínez-Balibrea, Anna Martínez-Cardús

microRNAs and cancer metabolism reprogramming: the paradigm of metformin

Claudio Pulito, Sara Donzelli, Paola Muti, Luisa Puzzo, Sabrina Strano, Giovanni Blandino

Original Article

Report of cancer incidence and mortality in China, 2010

Wanqing Chen, Rongshou Zheng, Siwei Zhang, Ping Zhao, Hongmei Zeng, Xiaonong Zou

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis

Jiezhong Chen, Kong-Nan Zhao, Chen Chen

Highlighted Reports in Galectins

Galectins in cancer: carcinogenesis, diagnosis and therapy

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Galectins in tumor angiogenesis

Arjan W. Griffioen, Victor L. Thijssen

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Review Article on MicroRNAs, Signalling Pathways and Diseases

Role of microRNAs in chemoresistance

Peter Magee, Lei Shi, Michela Garofalo

Editorial

Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?

Jayoung Kim, Wun-Jae Kim

Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era

Kimberly J. Payne, Abigail Benitez, Sinisa Dovat

Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?

Kevin P. Daly

Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized

Mark R. Walter

Safe anticoagulation when heart and lungs are “on vacation”

Marina A. Dobrovolskaia, Scott E. McNeil

γδ T cells and immunity to human malaria in endemic regions

Samarchith P. Kurup, John T. Harty

Apyrase as a novel therapeutic inhibitor of heterotopic ossification

Olin D. Liang, Anthony M. Reginato, Damian Medici

The CRISPR road: from bench to bedside on an RNA-guided path

Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort

Microbiome, a new dimension in cancer research

Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome

Irfana Muqbil, Ramzi M. Mohammad

Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?

Sarina Bains, Prasad S. Adusumilli

Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy

Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli

Radiotherapy: killing with complement

Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming

Getting to the core of fibrosis: targeting redox imbalance in aging

Louise Hecker, Victor J. Thannickal

Perspective

Integrating bevacizumab and radiation treatment of brain metastasis: is there sense and sensibility in this approach?

Emil Lou, Paul W. Sperduto

Commentary

Applications of iPSC-derived models of Gaucher disease

Daniel K. Borger, Elma Aflaki, Ellen Sidransky

The impact of sedation protocols on outcomes in critical illness

Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review

Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont

Update in genetic susceptibility in melanoma

Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig

State of the art management of metastatic gastroesophageal cancer

Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors

Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari

Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy

Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Letter to the Editor

Gene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs

Martin K. Childers, Alan H. Beggs, Ana Buj-Bello

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds

Noorjahan Panjwani

Editorial: Diabetes Mellitus

A look at the trend in diabetes-related complications in the U.S. over the past two decades: looking ahead

Chee W. Chia, Luigi Ferrucci

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease

Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease

David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease

Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Preface

Molecular medicine in the translational research era

Christina Piperi, Athanasios G. Papavassiliou

Quality in gastrointestinal endoscopy: the preface

Konstantinos Triantafyllou, Spyridon Michopoulos, Cesare Hassan

Editorial

“Remote” myokine protects from pulmonary ischemia/reperfusion injury by a surprising “proximal” control mechanism

Jürgen Bernhagen

Review Article

Tidal volume in acute respiratory distress syndrome: how best to select it

Michele Umbrello, Antonella Marino, Davide Chiumello

Quality in upper gastrointestinal endoscopic submucosal dissection

Flaminia Purchiaroni, Guido Costamagna, Cesare Hassan

Chromatin remodeling defects in pediatric brain tumors

Alexia Klonou, Danai Spiliotakopoulou, Marios S. Themistocleous, Christina Piperi, Athanasios G. Papavassiliou

Molecular mechanisms of mechanotransduction in psoriasis

Lina S. Malakou, Antonios N. Gargalionis, Christina Piperi, Evangelia Papadavid, Athanasios G. Papavassiliou, Efthimia K. Basdra

Quality in endoscopy training—the endoscopic retrograde cholangiopancreatography case

Ivan Jovanovic, Klaus Mönkemüller

The role of transient receptor potential polycystin channels in bone diseases

Maria A. Katsianou, Foteini G. Skondra, Antonios N. Gargalionis, Christina Piperi, Efthimia K. Basdra

DPP-4 inhibitors: a promising therapeutic approach against Alzheimer’s disease

Efthalia Angelopoulou, Christina Piperi

Physiology-guided management of hemodynamics in acute respiratory distress syndrome

Gustavo A. Cortes-Puentes, Richard A. Oeckler, John J. Marini

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Non-invasive ventilation in cardiogenic pulmonary edema

Giuseppe Bello, Paolo De Santis, Massimo Antonelli

How to measure quality in endoscopic ultrasound

Antonio Facciorusso, Rosario Vincenzo Buccino, Nicola Muscatiello

Current advances of targeting HGF/c-Met pathway in gastric cancer

Aristomenis Anestis, Ilianna Zoi, Michalis V. Karamouzis

Paediatric gliomas: diagnosis, molecular biology and management

Alexandros Blionas, Dimitrios Giakoumettis, Alexia Klonou, Eleftherios Neromyliotis, Ploutarchos Karydakis, Marios S. Themistocleous

Prediction of fluid responsiveness in ventilated patients

Mathieu Jozwiak, Xavier Monnet, Jean-Louis Teboul

Value of measuring esophageal pressure to evaluate heart-lung interactions—applications for invasive hemodynamic monitoring

Xavier Repessé, Antoine Vieillard-Baron, Guillaume Geri

Critical appraisal of guidelines for screening and surveillance of Barrett’s esophagus

Spyridon Michopoulos

What defines quality in small bowel capsule endoscopy

Ioannis V. Mitselos, Dimitrios K. Christodoulou

Current concepts in the management of stable ischemic heart disease and acute coronary syndrome in patients with hemophilia

Ahmad Y. Jabbar, Hassan Baydoun, Maissaa Janbain, Keith C. Ferdinand

Diagnostic molecular techniques in haematology: recent advances

Aikaterini Koutsi, Elisavet-Christina Vervesou

Interpretation of the transpulmonary pressure in the critically ill patient

Michele Umbrello, Davide Chiumello

Determinants of systemic venous return and the impact of positive pressure ventilation

David Berger, Jukka Takala

The role of epithelial growth factors and insulin growth factors in the adrenal neoplasms

Anna Angelousi, Georgios Kyriakopoulos, Narjes Nasiri-Ansari, Margarita Karageorgou, Eva Kassi

Effects of patient positioning on respiratory mechanics in mechanically ventilated ICU patients

Mehdi Mezidi, Claude Guérin

Ten quality indicators for endoscopic submucosal dissection: what should be monitored and reported to improve quality

Lorenzo Fuccio, Pradeep Bhandari, Roberta Maselli, Leonardo Frazzoni, Thierry Ponchon, Franco Bazzoli, Alessandro Repici

Assessing breathing effort in mechanical ventilation: physiology and clinical implications

Heder de Vries, Annemijn Jonkman, Zhong-Hua Shi, Angélique Spoelstra-de Man, Leo Heunks

Mechanical ventilation management during cardiothoracic surgery: an open challenge

Elena Bignami, Francesco Saglietti, Antonio Di Lullo

Cardiovascular failure and weaning

Philippe Vignon

Thyroid hormone receptor α1 as a novel therapeutic target for tissue repair

Constantinos Pantos, Iordanis Mourouzis

MALDI-TOF mass spectrometry technology for detecting biomarkers of antimicrobial resistance: current achievements and future perspectives

Georgia Vrioni, Constantinos Tsiamis, George Oikonomidis, Kalliopi Theodoridou, Violeta Kapsimali, Athanasios Tsakris

The basics of respiratory mechanics: ventilator-derived parameters

Pedro Leme Silva, Patricia R. M. Rocco

Histopathological, immunohistochemical, genetic and molecular markers of neuroendocrine neoplasms

Georgios Kyriakopoulos, Vasiliki Mavroeidi, Eleftherios Chatzellis, Gregory A. Kaltsas, Krystallenia I. Alexandraki

Management of hormone-receptor positive human epidermal receptor 2 negative advanced or metastatic breast cancers

Roger K. C. Ngan

Original Article

Monitoring of colonoscopy quality indicators in an academic endoscopy facility reveals adherence to international recommendations

Stefanos Karamaroudis, Aliki Stamou, Stamatia C. Vorri, Paraskevas Gkolfakis, Vasilios Papadopoulos, Georgios Tziatzios, Aikaterini Karagouni, Panagiota Katsouli, George D. Dimitriadis, Konstantinos Triantafyllou

Boiling and roasting treatment affecting the peanut allergenicity

Tong Zhang, Yunfeng Shi, Yanqing Zhao, Guowei Tang, Bing Niu, Qin Chen

Quantitative analysis and study of the mRNA expression levels of apoptotic genes BCL2, BAX and BCL2L12 in the articular cartilage of an animal model of osteoarthritis

Aristotelis Kourtis, Panagiotis G. Adamopoulos, Apostolos Papalois, Dimitrios C. Iliopoulos, George C. Babis, Andreas Scorilas

Health-related quality of life measure distinguishes between low and high clinical T stages in esophageal cancer

Biniam Kidane, Amir Ali, Joanne Sulman, Rebecca Wong, Jennifer J. Knox, Gail E. Darling

Determining association of rho kinase 1 gene polymorphisms with risk of Alzheimer’s disease: a multicenter pilot study

Ying Gao, Xia Li, Xiao-Hong Liu, Qian-Hua Zhao, Xiang-Qian Che, Qi-Hao Guo, Ru-Jing Ren, Gang Wang

Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia

Raquel Almansa, Leonor Nogales, Marta Martín-Fernández, Montse Batlle, Esther Villareal, Lucia Rico, Alicia Ortega, Guillermo López-Campos, David Andaluz-Ojeda, Paula Ramírez, Lorenzo Socias, Luis Tamayo, Jordi Vallés, Jesús F. Bermejo-Martín, Ignacio Martín-Loeches