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Focus on “Advances in Cardiology, Interventional Cardiology, Electrophysiology, and Structural... More >>
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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

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Annals of Translational Medicine is sponsored by the Affiliated Nanjing Jiangning Hospital of Nanjing Medical University.

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Original Article

Impact of smoking in patients undergoing transcatheter aortic valve replacement
Manyoo Agarwal, Sahil Agrawal, Lohit Garg, Guy L. Reed, Rami N. Khouzam, Uzoma N. Ibebuogu
Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction
Manyoo A. Agarwal, Lohit Garg, Carl J. Lavie, Guy L. Reed, Rami N. Khouzam
Stress-induced thrombus: prevalence of thromboembolic events and the role of anticoagulation in Takotsubo cardiomyopathy
Mark R. Heckle, Cody W. McCoy, Oluwaseun A. Akinseye, Rami N. Khouzam
Trends, predictors and outcomes of ischemic stroke and intracranial hemorrhage in patients with a left ventricular assist device
Muhammad Shahreyar, Tamunoinemi Bob-Manuel, Rami N. Khouzam, Mohammad W. Bashir, Samian Sulaiman, Oluwaseun Akinseye, Arindam Sharma, April Carter, Samuel Latham, Sanjay Bhandari, Arshad Jahangir
Severe sepsis and cardiac arrhythmias
Muhammad Shahreyar, Regina Fahhoum, Oluwaseun Akinseye, Sanjay Bhandari, Geetanjali Dang, Rami N. Khouzam

Review Article

Simultaneous acute cardio-cerebral infarction: is there a consensus for management?
Oluwaseun A. Akinseye, Muhammad Shahreyar, Mark R. Heckle, Rami N. Khouzam
Outcomes following transcatheter aortic valve replacement in patients with native aortic valve regurgitation
Tamunoinemi Bob-Manuel, Siri Kadire, Mark R. Heckle, Jiajing Wang, Uzoma N. Ibebuogu
When more is not better—appropriately excluding patients from mechanical circulatory support therapy
Mannu Nayyar, Kevin Michael Donovan, Rami N. Khouzam
A review of racial disparities in transcatheter aortic valve replacement (TAVR): accessibility, referrals and implantation
Tamunoinemi Bob-Manuel, Arindam Sharma, Amit Nanda, Devarshi Ardeshna, William Paul Skelton IV, Rami N. Khouzam
Permanent pacemaker insertion in patients with conduction abnormalities post transcatheter aortic valve replacement: a review and proposed guidelines
Tamunoinemi Bob-Manuel, Amit Nanda, Samuel Latham, Issa Pour-Ghaz, William Paul Skelton IV, Rami N. Khouzam
Asian-Indians: a review of coronary artery disease in this understudied cohort in the United States
Devarshi R. Ardeshna, Tamunoinemi Bob-Manuel, Amit Nanda, Arindam Sharma, William Paul Skelton IV, Michelle Skelton, Rami N. Khouzam
Incidence and predictors of acute coronary syndrome within a year following a negative stress test—a false sense of security: is routine screening any useful?
Issa Pour-Ghaz, Tamunoinemi Bob-Manuel, Hemnishil K. Marella, Jayna Kelly, Amit Nanda, William Paul Skelton IV, Rami N. Khouzam
Access site complications in transcutaneous aortic valve replacement: frequency, outcomes, prevention, and treatment
Samuel Latham, Tamunoinemi Bob-Manuel, Arindam Sharma, Amit Nanda, Devareshi Ardeshna, Rami N. Khouzam

Case Report

Double conduction through the atrioventricular node following acute medullary infarction: a case report
Salem A. Salem, Nadish Garg, Raed Abu Shama, Sunil Jha, Showkat Haji, Muhammed Shahreyar, Devarshi Ardeshna
The potential detrimental effects of calcium channel blockers’ overdose and current available management
Manyoo A. Agarwal, David Flatt, Rami N. Khouzam
Electrocardiographic artifact potentially misleading to the wrong management
Srishti Sareen, Mannu Nayyar, Brian Wheeler, Michelle Skelton, Rami N. Khouzam
Peri-procedural antibiotic prophylaxis in ventricular septal defect: a case study to re-visit guidelines
Nadish Garg, Mannu Nayyar, Rami N. Khouzam, Salem A. Salem, Devarshi Ardeshna
Acute right ventricular failure after orthotopic liver transplantation
Rohan M. Goswami, Rami N. Khouzam
Occlusion of right coronary artery by microembolization caused by excessive diagnostic catheter manipulation
Salem A. Salem, Showkat Haji, Nadish Garg, Rami N. Khouzam, Pooja Jagadish, Shadwan Alsafwah
Paradoxical emboli following a pulmonary embolus in the presence of a patent foramen ovale
Khalid Najib, Mark Heckle, Sameh Goubran, Rhadika Mehta, Rohan Goswami, Rami N. Khouzam


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.



Review Article

Original Article

Technical Note

Column in Hypertension: Editorial