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Annals of Translational Medicine is endorsed by the Bonnie J. Addario Lung Cancer Foundation (ALCF), the Ming-Yi Medical Charity Foundation of Guangdong Province, the international Inspire2Live Patient Advocates organization, and the Hellenic Cooperative Oncology Group.


the Brazilian Society of Thoracic Surgery(SBCT)

the Brazilian Society of Thoracic Surgery(SBCT) the Bonnie J. Addario Lung Cancer Foundation (ALCF)

Original Article on Lung Transplantation

The value of high-resolution HLA in the perioperative period of non-sensitized lung transplant recipients
Ji Zhang, Dong Liu, Caixin Zhang, Min Zhou, Jian Lv, Hongmei Wang, Hang Yang, Li Fan, Bo Wu, Jingyu Chen
Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage
Dong Wei, Fei Gao, Zhenkun Yang, Wei Wang, Yinglun Chen, Yan Lu, Jingyu Chen
Clinical outcomes of ceftazidime-avibactam in lung transplant recipients with infections caused by extensively drug-resistant gram-negative bacilli
Wenhui Chen, Lingxiao Sun, Lijuan Guo, Bin Cao, Yingmei Liu, Li Zhao, Binghuai Lu, Binbin Li, Jingyu Chen, Chen Wang
Can the preoperative nutritional risk score be a predictor of the outcomes in critically ill patients of lung transplantation: a retrospective study
Kongmiao Lu, Huixing Li, Yinglun Chen, Bo Wu, Ji Zhang, Man Huang, Jingyu Chen

Review Article on Lung Transplantation

China lung transplantation developing: past, present and future
Bo Wu, Chunxiao Hu, Wenhui Chen, Jianxing He, Gening Jiang, Ji Zhang, Dong Liu, Xiaoshan Li, Dong Wei, Guohui Jiao, Chen Wang, Jingyu Chen

Editorial on Lung Transplantation

Extended ex vivo lung perfusion—abridged expense
Harpreet Singh Grewal, Atul C. Mehta, Alejandro Bribiesco
Is perfusate exchange during ex vivo lung perfusion beneficial?
Christina C. Kao, Amit D. Parulekar
Nutritional status and lung transplantation: an intriguing problem
Mario Nosotti, Michele Ferrari
HLA typing in lung transplantation: does high resolution fit all?
Silvia Deaglio, Antonio Amoroso, Mauro Rinaldi, Massimo Boffini
High-resolution human leukocyte antigen typing and early post-transplant outcomes: more than meets the eye
Annelore Sacreas, Stijn E. Verleden


Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)
Laishuan Wang, Yuan Shi, Tiantian Xiao, Jianhua Fu, Xing Feng, Dezhi Mu, Qi Feng, Mingyan Hei, Xiaojing Hu, Zhankui Li, Guoping Lu, Zezhong Tang, Yajuan Wang, Chuanqing Wang, Shiwen Xia, Jianqing Xu, Yujia Yang, Jie Yang, Mei Zeng, Jun Zheng, Wei Zhou, Xiaoyu Zhou, Xiaoguang Zhou, Lizhong Du, Shoo K. Lee, Wenhao Zhou, on behalf of the Working Committee on Perinatal, and Neonatal Management for the Prevention and Control of the 2019 Novel Coronavirus Infection

Column in Laboratory Medicine

Which lessons shall we learn from the 2019 novel coronavirus outbreak?
Camilla Mattiuzzi, Giuseppe Lippi


Will the 40-gene expression classifier predict responders to EGFR targeted chemotherapy for the invasive bladder cancer patients?
Jayoung Kim, Wun-Jae Kim
Translating basic science discoveries to clinical practice—Let us not repeat the naiveté of the pre-omics era
Kimberly J. Payne, Abigail Benitez, Sinisa Dovat
Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection?
Kevin P. Daly
Elucidating new drug targets in psoriasis by gene profiling: an opportunity to be seized
Mark R. Walter
Safe anticoagulation when heart and lungs are “on vacation”
Marina A. Dobrovolskaia, Scott E. McNeil
γδ T cells and immunity to human malaria in endemic regions
Samarchith P. Kurup, John T. Harty
Apyrase as a novel therapeutic inhibitor of heterotopic ossification
Olin D. Liang, Anthony M. Reginato, Damian Medici
The CRISPR road: from bench to bedside on an RNA-guided path
Benjamin Garcia-Bloj, Colette Moses, Pilar Blancafort
Microbiome, a new dimension in cancer research
Antonio Galvao Neto, Azore-Dee Bradshaw, Zhiheng Pei
Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome
Irfana Muqbil, Ramzi M. Mohammad
Is spread through alveolar spaces, the newly recognized pattern of invasion, a potential game changer in lung adenocarcinoma?
Sarina Bains, Prasad S. Adusumilli
Significance of IASLC/ATS/ERS classification for early-stage lung adenocarcinoma patients in predicting benefit from adjuvant chemotherapy
Yusuke Takahashi, Takashi Eguchi, Sarina Bains, Prasad S. Adusumilli
Radiotherapy: killing with complement
Jean F. Regal, Kenneth J. Dornfeld, Sherry D. Fleming
Getting to the core of fibrosis: targeting redox imbalance in aging
Louise Hecker, Victor J. Thannickal
The Art of War and oncology: applying the principles of strategy and tactics to greater effect in the era of targeted therapy
Emil Lou
Protecting functional β cells with a therapeutic peptide
Meghan L. Marré, Jon D. Piganelli, Eddie A. James
Acidosis and citrate: provocative interactions
Kathleen S. Hering-Smith, L. Lee Hamm

Original Article

Hyaluronan expression in primary and secondary brain tumors
Laurence Jadin, Sandra Pastorino, Rebecca Symons, Natsuko Nomura, Ping Jiang, Tiffany Juarez, Milan Makale, Santosh Kesari
Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy
Melissa A. Goddard, David L. Mack, Stefan M. Czerniecki, Valerie E. Kelly, Jessica M. Snyder, Robert W. Grange, Michael W. Lawlor, Barbara K. Smith, Alan H. Beggs, Martin K. Childers

Review Article

Osteonecrosis of the knee: review
Ammar R. Karim, Jeffrey J. Cherian, Julio J. Jauregui, Todd Pierce, Michael A. Mont
Update in genetic susceptibility in melanoma
Miriam Potrony, Celia Badenas, Paula Aguilera, Joan Anton Puig-Butille, Cristina Carrera, Josep Malvehy, Susana Puig
State of the art management of metastatic gastroesophageal cancer
Adrian G. Murphy, David Lynch, Ronan J. Kelly
Colorectal cancer genomics and designing rational trials
Sebastian Mondaca, Rona Yaeger
Emerging application of genomics-guided therapeutics in personalized lung cancer treatment
Aubhishek Zaman, Trever G. Bivona
Aminoquinoline antimalarial therapy in dermatomyositis—are we missing opportunities with respect to comorbidities and modulation of extracutaneous disease activity?
Richard D. Sontheimer


Applications of iPSC-derived models of Gaucher disease
Daniel K. Borger, Elma Aflaki, Ellen Sidransky
The impact of sedation protocols on outcomes in critical illness
Benjamin Scott, Tobias Eckle

Review Articles

Functional role of microvesicles in gastrointestinal malignancies
Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng
Effect of high fat-diet and obesity on gastrointestinal motility
Mazen Al Mushref, Shanthi Srinivasan
The physiological roles of secretin and its receptor
Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Highlighted Reports in Galectins

Role of galectins in re-epithelialization of wounds
Noorjahan Panjwani

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test
Takahiro Uotani, David Y. Graham

Review Article on MicroRNAs, Signalling Pathways and Diseases

MicroRNAs in congenital heart disease
Tanya Smith, Cha Rajakaruna, Massimo Caputo, Costanza Emanueli

Review Article on Toward Precision Medicine in Neurological Diseases

Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
David D. Bushart, Geoffrey G. Murphy, Vikram G. Shakkottai

Focus on Toward Precision Medicine in Neurological Diseases

Toward precision medicine in Alzheimer’s disease
Christiane Reitz

Editorial on Cardiovascular Disease and Cardiometabolic Risk: Advances in Understanding Pathophysiology, Public Health Burden and Clinical Care

Advances in resistant hypertension
David A. Calhoun

Below are the latest Annals of Translational Medicine articles published online ahead of print publication.

Big-data Clinical Trial Column

Case Report


Editorial Commentary

Letter to the Editor

Original Article

Review Article

Surgical Technique

Study Protocol

Technical Note