Vol 7, Supplement 1 (March 2019): Annals of Translational Medicine

Patient centered care for prostate cancer—how can artificial intelligence and machine learning help make the right decision for the right patient?

Nathan C. Wong, Bobby Shayegan

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Meningeal lymphatics in aging and Alzheimer’s disease

Russell J. Jaffe, Rajnish S. Dave, Siddappa N. Byrareddy

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Pembrolizumab in advanced gastric cancer: pioneering or prosaic?

Sarbajit Mukherjee, Steven N. Hochwald

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Improving detection combined with targeted therapy for small hepatocellular carcinoma

Shengyang Qiu, Long R. Jiao

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Is the onset of adverse effects of immunotherapy always bad news for the patients…?—certainly not!

Paul Hofman

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Fluorescence-guided surgery in cancer treatment: current status and future perspectives

Yongchang Zheng, Huayu Yang, Henan Wang, Kai Kang, Wenkai Zhang, Gang Ma, Shunda Du

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Blocking the PD-1/PD-L1 axis in advanced prostate cancer: are we moving in the right direction?

Andre P. Fay, Emmanuel S. Antonarakis

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Pathophysiology of pain in patients with peritoneal endometriosis

Simone Ferrero, Valerio Gaetano Vellone, Fabio Barra

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Lessons learned by features of pancreatic ductal adenocarcinoma and its tumor microenvironment

Alex B. Blair, Vincent P. Groot, Jin He

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American Joint Committee on Cancer 8^th edition staging—an improvement in prognostication in HPV-associated oropharyngeal cancer?

Jon Mallen-St Clair, Allen S. Ho

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Eighth edition of the American Joint Committee on Cancer staging system for soft tissue sarcoma of the trunk and extremity: in search of a better staging system

Kazuhiro Tanaka, Hiroshi Tsumura

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Cancer staging for rare cancers: should the American Joint Committee on Cancer have a separate staging classification for external auditory canal cancer?

Jonathan Robert Clark, Hubert Low, Ruta Gupta

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Mitochondrial cytochrome c oxidase is not the primary acceptor for near infrared light—it is mitochondrial bound water: the principles of low-level light therapy

Andrei P. Sommer

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Pembrolizumab for recurrent/metastatic head and neck cancer: equally promising for Asian patients?

Wenda Ye, Nicole C. Schmitt

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Single nucleotide polymorphisms in angiogenesis-related genes and outcomes from antiangiogenic therapies in renal cell carcinoma: really a step towards personalized oncology, or not at all?

Camillo Porta, Laura Cosmai, Mimma Rizzo, Mario Melazzini

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Ultrasound patterns of pulmonary edema

Gino Soldati, Marcello Demi, Libertario Demi

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There is another new method for cryopreserving small numbers of human sperm cells

Alessio Paffoni, Simone Palini

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Revisiting AJCC TNM staging for renal cell carcinoma: quest for improvement

Umang Swami, Roberto H. Nussenzveig, Benjamin Haaland, Neeraj Agarwal

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Monocyte-platelet cross-talk in peripheral artery disease—how much does the pathogenesis of atherosclerosis depend on anatomical location?

Richard A. Brown, Gregory Y. H. Lip

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The variables of force generation and application to cartilage, ligaments and bone remain to be defined

Robert A. Teitge

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Orphan noncoding RNAs: novel regulators and cancer biomarkers

Mona Teng, Lydia Y. Liu, Junjie Tony Hua, Sujun Chen, Housheng Hansen He

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Immunotherapeutic strategies in patients with advanced head and neck squamous cell carcinoma

Maysaloun Merhi, Afsheen Raza, Varghese Inchakalody, Abdul Rahman Zar, Shahab Uddin, Said Dermime

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Important caveats of KEYNOTE-045: relevance of these findings in the current and future therapeutic paradigm

Julio Slongo, Rohit K. Jain, Philippe E. Spiess

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The use of baseline tumor size to prognosticate overall survival in stage IV melanoma patients treated with the PD-1 inhibitor pembrolizumab

Philip Friedlander

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Norepinephrine, more than a vasopressor

Emilio Daniel Valenzuela Espinoza, Glenn Hernandez, Jan Bakker

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A nomogram for predicting survival of patients with locally advanced pancreatic cancer treated with chemoradiotherapy: an editorial comment

Joyce Wong

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Electronic health records, physician workflows and system change: defining a pathway to better healthcare

Carla M. Pugh

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Nephron repair: powered by anaerobic energy metabolism

Brooke E. Chambers, Rebecca A. Wingert

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Nanoparticles as theranostic vehicles in prostate cancer

Rafael Morales-Barrera, Cristina Suárez, Joaquín Mateo, Macarena González, Joan Carles

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Mind the gap: renal tubule responses to injury and the role of Cxcl12 and Myc

Veronika Sander, Richard W. Naylor, Alan J. Davidson

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Anterior knee pain as a functional problem of complex dynamic inter-play of living structures

Werner Müller

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Is an immune checkpoint inhibitor really a hopeless therapeutic choice for EGFR-mutant non-small cell lung cancer (NSCLC) patients?

Kei Kunimasa, Kazumi Nishino, Toru Kumagai

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Strengthening the foundation of kidney cancer treatment and research: revising the AJCC staging system

Hiren V. Patel, Arnav Srivastava, Brian Shinder, Evita Sadimin, Eric A. Singer

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Anatomy is not enough: the crucial role of biology and genetics in AJCC eighth edition of the TNM classification for breast cancer

Francesca Magnoni, Giuseppe Accardo, Elisabetta Rossi, Paolo Veronesi, Giovanni Corso

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When survival curves cross: are we at a crossroads of immunotherapy in gastric cancer?

Jun Gong, Joseph Chao

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Editorial on “Risk prediction models for cancer-specific survival following cytoreductive nephrectomy in the contemporary era”

Yasmin Abu-Ghanem, Jacob Ramon

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The potential role of germline single nucleotide polymorphisms for selecting the ideal candidates for sunitinib therapy in patients with locally-advanced renal cell carcinoma

Alberto Martini, Reza Mehrazin

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Adjuvant therapy in renal cell carcinoma—is pharmacogenomics assessment another element to select our patients?

Vincenzo Di Nunno, Veronica Mollica, Lidia Gatto, Matteo Santoni, Giulia Sorgentoni, Nicola Battelli, Francesco Massari

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Optimizing renal function and outcome of patients with cT2 renal cell carcinoma

Matteo Santoni, Giada Maiorani, Luca Faloppi, Vincenzo Di Nunno, Lidia Gatto, Francesco Massari, Nicola Battelli

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Stem cell therapy in diabetic men with erectile dysfunction: a step closer to safe and effective regenerative technology

Eric Chung

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UICC and AJCC 8th edition tumor-nodes-metastasis (TNM) classifications for patients treated with radical prostatectomy: reliable but not infallible prognostic tools

Marco Bandini, Felix Preisser

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Chronic obstructive pulmonary disease alters immune cell composition and immune checkpoint inhibitor efficacy in non-small cell lung cancer

Marcos Magalhães Filho, Pedro N. Aguiar Jr, Ramon Andrade de Mello

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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required

Nicolas Jonckheere, Isabelle Van Seuningen

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Is smoking causally-associated with hepatitis B virus-related hepatocellular carcinoma?

Kyrillus S. Shohdy, Omar Abdel-Rahman

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Predicting renal function after kidney cancer surgery: a tool for clinical decision making

Natalie R. Swavley, Alessandro Veccia, Riccardo Autorino

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Potential biological and clinical benefit of prostate-directed interventions in patients with metastatic prostate cancer

Makito Miyake, Takuya Owari, Nobumich Tanaka, Kiyohide Fujimoto

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What is the most durable construct for a forefoot amputation, traditional transmetatarsal amputation or a medial ray sparing procedure?

Lawrence A. Lavery, Peter A. Crisologo, Metin Yavuz

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Systemic therapy of elderly patients with advanced non-small cell lung cancer—individualized treatment is key

Robert Pirker

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Thyroid cancer staging and genomics

Ashok R. Shaha, R. Michael Tuttle

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Encouraging early outcomes in cancer and leukemia group B (CALGB)/Alliance 140503: patient selection, not extent of resection, is the key to perioperative success

Kyle G. Mitchell, Mara B. Antonoff

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Implementation of staging systems in clinical practice for cutaneous squamous cell carcinoma

Javier Cañueto

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Eighth edition of the American Joint Committee on Cancer staging system: are we getting closer to the ideal classification for gastric cancer?

Karen Elizabeth Padilla-Leal, Heriberto Medina-Franco

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An extended overall survival analysis of pemetrexed and carboplatin with or without pembrolizumab as first-line therapy for advanced non-squamous non-small cell lung cancer

Muhammad Zubair Afzal, Konstantin H. Dragnev, Keisuke Shirai

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Pathological nodal staging score for renal cell carcinoma: how to build reliable therapeutic choices basing on assumptions

Melissa Bersanelli, Sebastiano Buti, Matteo Santoni, Francesco Ziglioli, Umberto Maestroni

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Vol 7, Supplement 1 (March 2019): Annals of Translational Medicine

Editorial Commentary