Vol 7, Supplement 8 (December 2019): Annals of Translational Medicine

Editorial Commentary

The evolving treatment paradigm for BRAF V600 mutant colorectal cancer
Jeremy D. Kratz, Dustin A. Deming
Liver impairment in critical illness and sepsis: the dawn of new biomarkers?
Martin Kluge, Frank Tacke
Comparing total hip arthroplasty and hemiarthroplasty in the treatment of hip fracture
Nicholas J. Tucker, Atul F. Kamath
Variability of relative cerebral blood volume measurements of recurrent glioma
Laura K. Reed, Jason H. Huang
Two-stage revision surgery for periprosthetic joint infection following total hip arthroplasty
Timothy J. Fowler, Adrian Sayers, Michael R. Whitehouse
Tumor modeling maintains diverse pathology in vitro
Michael E. Bregenzer, Eric N. Horst, Pooja Mehta, Caymen M. Novak, Taylor Repetto, Catherine S. Snyder, Geeta Mehta
Succinate links mitochondria to deadly bacteria in cystic fibrosis
Speranza Esposito, Valeria Rachela Villella, Federica Rossin, Antonella Tosco, Valeria Raia, Alessandro Luciani
Is dyschloremia a marker of critical illness or euchloremia an interventional target to improve outcomes?
Fabrizio Canepa-Escaro, Javier A. Neyra
The effect of 3D scoliosis correction on the length of the spinal canal
Tom P. C. Schlösser, René M. Castelein
Oral antibiotic therapy in diabetic foot osteomyelitis: one small step or a giant leap of faith?
Prashanth R. J. Vas, Maria Demetriou, Nikolaos Papanas
Unique behavior of brain metastases during the treatment of nivolumab for metastatic renal cell carcinoma
Tsunenori Kondo, Hiroki Ishihara
Comparison of narrow-band UVB vs. psoralen with UVA phototherapy for early-stage mycosis fungoides
Amrita Goyal
Determining the most important factors in hospital readmission following surgery for lung cancer
Masayuki Nakao, Junji Ichinose, Yosuke Matsuura, Sakae Okumura, Mingyon Mun
Antithrombotic therapy after coronary artery stenting in atrial fibrillation: dual therapy encompassing NOAC plus P2Y12 inhibitor is ready for prime time!
Andreas Goette
Safety evaluation of intra-arterial cell delivery in stroke patients—a framework for future trials
Johannes Boltze, Jukka Jolkkonen
Sequential treatment of metastatic renal cancer in a complex evolving landscape
Javier C. Angulo, Charles H. Lawrie, José I. López
Surgical metastasectomy for renal cell carcinoma: which patients are the real candidates for surgery?
Satoshi Kato, Satoru Demura, Hideki Murakami, Hiroyuki Tsuchiya
Before it catches the eye...
Marian J. Mourits, Geertruida H. de Bock
Can immune biomarkers predict benefit from targeted agents in metastatic renal cell carcinoma?
Renate Pichler, Manuela Schmidinger
Is there a role for immunotherapy in ovarian cancer?
Gaia Giannone, Giorgio Valabrega
The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression
Olivier Feron
Epigallocatechin gallate in multiple system atrophy (PROMESA)
Kurt A. Jellinger
The new frontier of hepatitis C virus (HCV)-mismatched heart and lung transplantation
Piergiorgio Solli, Giampiero Dolci, V. Marco Ranieri
Intraoperative contrast enhanced ultrasound adds some important details to the endovascular aortic aneurysm repair completion control
Chiara Mascoli, Gianluca Faggioli, Enrico Gallitto, Rodolfo Pini, Mauro Gargiulo
PD-1 inhibition: a novel approach to the treatment of progressive multifocal leukoencephalopathy
Joseph R. Berger
Elderly patients and PD-L1-positive advanced non-small cell lung cancer: is pembrolizumab monotherapy effective and safe?
Cesare Gridelli, Assunta Sgambato
Is there value of tumor stromal infiltrating lymphocytes for response assessment to chemoradiation in esophageal squamous cell carcinoma?
Xin Wang, Wang Jing, Steven H. Lin
Brake adjustment: Ca2+ entry pathway provides a novel target for acute pancreatitis therapy
Richard T. Waldron, Aurelia Lugea, Stephen J. Pandol
Changing the diagnostic approach to diabetes insipidus: role of copeptin
Anna Grandone, Pierluigi Marzuillo, Giuseppa Patti, Silverio Perrotta, Mohamad Maghnie
Therapeutic potential of vascular stem cells for anterior cruciate ligament reconstruction
Tomoyuki Matsumoto, Koji Takayama, Shinya Hayashi, Takahiro Niikura, Takehiko Matsushita, Ryosuke Kuroda
Programmed cell death protein 1/programmed death ligand-1 checkpoint blockade meets patient-derived organoids
Lejia Sun, Huayu Yang, Yilei Mao
Restaging after chemoradiotherapy for locally advanced esophageal cancer
Ingmar L. Defize, Richard van Hillegersberg, Stella Mook, Gert J. Meijer, Steven H. Lin, Jelle P. Ruurda, Peter S. N. van Rossum
Utilizing gene expression profiles to characterize tumor infiltrating lymphocytes in cancers
Ching-Hsuan Chen, Tzu-Pin Lu
Intra-operative contrast enhanced ultrasound as an adjunct to detect persistent type two endoleak after endovascular repair of abdominal aortic aneurysms
Regent Lee, Ediri Sideso
Adjuvant radiotherapy in prostate cancer patients with positive margins or extracapsular extension
Chandler Bronkema, Nikola Rakic, Firas Abdollah
Therapeutic potential of microRNAs in the regulation of cancer energy metabolism
Misa Yamamoto, Kenjiro Sawada, Tadashi Kimura
Improving survival in immunocompromised patients with hypoxemic acute respiratory failure
Guillaume Dumas, Virginie Lemiale, Alexandre Demoule, Elie Azoulay
The PEMBRO-RT phase II randomized trial and the evolution of therapy for metastatic non-small cell lung cancer: a historical perspective
Steven E. Schild
The inflammatory response from stereotactic body proton therapy versus stereotactic body radiation therapy: implications from early stage non-small cell lung cancer
Xingzhe D. Li, Charles B. Simone II
Does elevated urinary Dkkopf-3 level predict vulnerability to kidney injury during cardiac surgery?
Matthew B. Lanktree, York Pei
Use of check-point inhibitors in the treatment of progressive multifocal leukoencephalopathy
Luis Miguel Juárez-Salcedo, Samir Dalia
Checkpoint inhibitors and progressive multifocal leukoencephalopathy: friends of foes?
Daniele Focosi, Marco Tuccori, Fabrizio Maggi
MicroRNA targeting energy metabolism in ovarian cancer: a potent contender for future therapeutics
Siddhika Pareek, Aritro Nath, R. Stephanie Huang
New insights into the association between non-alcoholic fatty liver disease and atherosclerosis
Alejandro Valencia-Rodríguez, Alfonso Vera-Barajas, Beatriz Barranco-Fragoso, Deyanira Kúsulas-Delint, Xingshun Qi, Nahum Méndez-Sánchez
Impact of rapid socioeconomic development in China on nutritional status in children: two sides of a coin
Tena Niseteo, Iva Hojsak
Circular RNAs as diagnostic tool for renal transplant patients with acute rejection
Joseph B. Moore IV, Michael L. Merchant, Shizuka Uchida
Proteomic analysis of PAX8 alterations provides new insights into its role as a master regulator of migration in high-grade serous ovarian cancer
Tania Gamberi
Developing effective and efficient genomic educational tools for our diverse population
Julia Wynn, Wendy K. Chung
Neoantigens from the bench to the bedside: new prospective for ovarian cancer immunotherapy
Chiara Napoletano, Filippo Bellati
Glycosylation alterations in acute pancreatitis and pancreatic cancer: CA19-9 expression is involved in pathogenesis and maybe targeted by therapy
Ionut Negoi, Mircea Beuran, Sorin Hostiuc, Massimo Sartelli, Alaa El-Hussuna, Enrique de-Madaria
Sugammadex in the management of myasthenic patients undergoing surgery: beyond expectations
Michele Carron, Alessandro De Cassai, Federico Linassi
Synergistic clinical efficacy of niraparib in combination with pembrolizumab in patients with recurrent platinum-resistant ovarian carcinoma
Joan Tymon-Rosario, Burak Zeybek, Chanhee Han, Alessandro D. Santin
Gut microbiome, antibiotic use, and immunotherapy responsiveness in cancer
Jarred P. Reed, Suzanne Devkota, Robert A. Figlin
Percentage of tumor-infiltrating lymphocytes after chemoradiation therapy for locally advanced esophageal squamous cell carcinoma: a biomarker for pathological response rates and cancer-specific survival?
Shawn S. Groth, Bryan M. Burt
Serial bipolar androgen therapy (sBAT) using cyclic supraphysiologic testosterone (STP) to treat metastatic castration-resistant prostate cancer (mCRPC)
John T. Isaacs, W. Nathaniel Brennen, Samuel R. Denmeade
Complex renal masses: partial or no partial nephrectomy?
Riccardo Lombardo, Costantino Leonardo, Anton Zarraonandia, Andrea Tubaro, Cosimo De Nunzio
The role of immunotherapy in the management of patients with renal cell carcinoma and brain metastases
Jaleh Fallah, Manmeet S. Ahluwalia
Immunohistochemistry as a tool for screening rare renal cancers
Cissy Yong, Grant D. Stewart, Christian Frezza
Impact of circulating tumor DNA early detection and serial monitoring in the management of stage I to III colorectal cancer
Diana Bello Roufai, François-Clément Bidard
Signals from SABR-COMET time to move on to phase III studies
Michael T. Milano, Amit K. Chowdhry, Joseph K. Salama, Steven J. Chmura
Acute kidney injury after partial nephrectomy: transient or permanent kidney damage?—Impact on long-term renal function
Giuseppe Rosiello, Umberto Capitanio, Alessandro Larcher
CA19-9 as a therapeutic target in pancreatitis
Shingo Kato, Kazufumi Honda
The novel and critical role of von Hippel-Lindau in nephron formation
Soyoung Park, So-mi Kang, Bum-Joon Park
Paradigm shift in local consolidative therapy for oligometastatic non-small cell lung cancer: a meta-analysis
Christopher Cao, Adam Chakos, Allen Guo, John J. Park, Tajalli Saghaie, Prunella Blinman
The prognostic significance of preexisting diabetes in patients with surgically treated renal cell carcinoma: the ongoing debate
Ho Won Kang, Yong-June Kim
Gene-environment interactions determine risk for dementia: the influence of lifestyle on genetic risk for dementia
Kelley T. Patten, Pamela J. Lein
Promotion of synaptogenesis and neural circuit development by exosomes
Jun Yamada, Shozo Jinno
Immunohistochemical screening for the diagnosis of succinate dehydrogenase-deficient renal cell carcinoma and fumarate hydratase-deficient renal cell carcinoma
Kiril Trpkov, Farshid Siadat
Prevention and control of intensive care unit-acquired carbapenem-resistant Klebsiella pneumoniae: need for a multimodal approach
Arta Karruli, Roberto Andini, Antonio Corcione, Emanuele Durante-Mangoni
EGFR mutations in lung cancer: not all equal in the eyes of the immune system?
Kwun M. Fong, Brett G. M. Hughes, Zarnie Lwin, Ian A. Yang
RBP3: a possible prognostic marker and therapeutic target in diabetic retinopathy
Dario Rusciano, Paola Bagnoli
Video-assisted thoracic surgery lobectomy oncologically is equal to the open thoracotomy one
Marcin Zieliński
Mismatch repair deficiency/microsatellite instability testing as predictive immunotherapy biomarkers—possible diagnostic missteps trusting a single method
Ioanna Gazouli, George Zarkavelis, Davide Mauri, George Pentheroudakis
The SONAR study—is there a future for endothelin receptor antagonists in diabetic kidney disease?
Avivit Cahn, Simona Cernea, Itamar Raz
Complete revascularisation in STEMI: consider the benefits but do not forget the risks!
Andreas Mitsis, Alessandro Spirito, Marco Valgimigli
Drowning in data: early responses of renal cortical collecting duct cells to lithium
John Leader, Jennifer Bedford, Robert J. Walker
Are we approaching a new era in the treatment of anemia of chronic kidney disease patients?
Francesco Locatelli, Lucia Del Vecchio
Prolyl hydroxylase domain inhibitors: a new era in the management of renal anemia
Yu Kurata, Tetsuhiro Tanaka, Masaomi Nangaku
Novel approaches targeting mitochondrial fission to deplete stem-like tumor cells in prostate cancer and improve treatment outcomes
Antonino Passaniti, Arif Hussain
The volume-outcome relationship in kidney cancer: is more really better?
Brian T. Kadow, Shreyas S. Joshi, Alexander Kutikov, Elizabeth Handorf, Marc C. Smaldone, Robert G. Uzzo, Daniel M. Geynisman
The risks of converting post-hoc findings into primary outcomes in subsequent trials
Filipe B. Rodrigues, Joaquim J. Ferreira
More than just a screen to liberate from mechanical ventilation: treat to keep extubated?
Jie Li, J. Brady Scott, Jun Duan, Kai Liu, James B. Fink
Immune-checkpoint inhibitors and the importance of concomitant medications: focus on antibiotics
Chiara Casadei, Cristian Lolli, Alberto Farolfi
Single-cell RNA profiling of glomerular cells in diabetic kidney: a step forward for understanding diabetic nephropathy
María José Soler, Daniel Batlle
Transvaginal ultrasound-guided biopsy of adenomyosis
Simone Ferrero, Carolina Scala, Valerio Gaetano Vellone, Ennio Biscaldi, Fabio Barra
Renal double negative T cells: unconventional cells in search of a function
Raphael A. Nemenoff, Emily K. Kleczko, Katharina Hopp
“Early thrombus removal” in iliac-femoral deep vein thrombosis for prevention of post-thrombotic syndrome
Benilde Cosmi, Gualtiero Palareti
Carbapenem-resistant Klebsiella pneumoniae—impact of infection-prevention and control interventions
Isabelle Vock, Sarah Tschudin-Sutter
The limits of complex partial nephrectomy: are there any?
Vignesh T. Packiam, R. Houston Thompson
Erlotinib plus bevacizumab for EGFR-mutant advanced non-squamous non-small-cell lung cancer patients: ready for first-line?
Helen Adderley, Christoph Jakob Ackermann, Raffaele Califano
Cytoreductive nephrectomy following treatment with anti-vascular endothelial growth factor-targeted agents: is it surgically safe?
Hideaki Miyake
How children’s glue fixes a decades old enigma
Michael A. Rieger
Role of immunotherapy in metastatic renal cell cancer: past, present and future
Amos Lal, Kamal Kant Sahu, Vishal Jindal, Ajay Kumar Mishra, Ahmad Daniyal Siddiqui
Classification of solid renal tumor with oncocytic/eosinophilic cytoplasm: is hybrid oncocytic/chromophobe renal tumor a subtype of oncocytoma, chromophobe renal cell carcinoma, or a distinct tumor entity?
Shuji Mikami, Naoto Kuroda, Yoji Nagashima, Chisato Ohe, Hiroyuki Hayashi, Ryuichi Mizuno, Mototsugu Oya, Kaori Kameyama
Is serotonin pathology a good biomarker in vivo for early Parkinson’s disease?
Celia Painous, Andres Perissinotti, Maria J. Martí
Standard of usual care defines effectiveness of early goal directed therapy
Vikram Mukherjee, Jan Bakker
Weaning off mechanical ventilation: much less an art, but not yet a science
Paolo Navalesi, Andrea Bruni, Eugenio Garofalo, Eugenio Biamonte, Federico Longhini, Pamela Frigerio
Circulating tumor cell-based or tissue biopsy-based AR-V7 detection: which provides the greatest clinical utility?
Arpit Rao, Emmanuel S. Antonarakis
Non-selective beta blockers in cirrhosis: time to extend the indications?
Dev Katarey, Rajiv Jalan
Is it “hybrid” or “intermediate”?—more than just a semantic issue in oncocytic renal cell tumors
Diana Montezuma, Carmen Jerónimo, Rui Henrique
Enhanced recovery after surgery pathways in thoracic surgery, do they end at discharge?
Maria Rodriguez, Maria Aymerich
Circulating tumour DNA in early stage colorectal cancer: can blood tell all?
Yat Hang To, Margaret Lee, Peter Gibbs, Jeanne Tie
Toxicity of pelvic nodal radiation for localized prostate cancer
Waqar Haque, E. Brian Butler, Bin S. Teh
Do we have a “game changer” in treating patients with brain metastasis from renal cell carcinoma?
Olga Vornicova, Gil Bar-Sela
Definitive radiation for early stage lung cancer: who is medically inoperable?
Gonzalo Varela, Nuria M. Novoa
The importance of antiandrogen in prostate cancer treatment
Camille Lanz, Mostefa Bennamoun, Petr Macek, Xavier Cathelineau, Rafael Sanchez-Salas
Partial nephrectomy versus thermal ablation for clinical T1 renal tumours
Tobias Klatte, Grant D. Stewart
A TITAN step forward: apalutamide for metastatic castration-sensitive prostate cancer
Daniel Hyuck-Min Kwon, Terence Friedlander
Reducing dissemination of carbapenem-resistant Klebsiella pneumoniae
Matteo Bassetti, Daniele Roberto Giacobbe
Nivolumab without brain radiotherapy is insufficient for the treatment of most patients with brain metastases from clear cell renal cell carcinoma
Amit K. Chowdhry, Sara J. Hardy, Michael T. Milano
BRAF mutant metastatic colorectal cancers: new arrows in our quiver
Chiara Cremolini, Roberto Moretto, Gemma Zucchelli, Alfredo Falcone
Good news from the Da Qing Diabetes Prevention Outcome Study—healthy lifestyles result in long-term cardiovascular benefits
Matti Uusitupa
Management of brain metastases from renal cell carcinoma
Suguru Shirotake
Are the long-term outcomes of percutaneous ablation for clinical stage T1 renal tumors similar to those of partial nephrectomy?
Roy Mano, A. Ari Hakimi
Radiation and cardiovascular disease
Nicolas Palaskas, Ashley Patel, Syed Wamique Yusuf
Secondary cytoreduction in platinum-sensitive recurrent ovarian cancer: are we missing something?
Claudia Marchetti, Andrea Rosati, Giovanni Scambia, Anna Fagotti
Dual specificity phosphatase 6 as a new therapeutic target candidate for epithelial ovarian cancer
Seiya Sato, Hiroaki Itamochi
An important step in establishing a treatment strategy for small renal masses of clear cell renal cell carcinoma based on the significance of adverse histopathologic features on tumor needle biopsy
Suguru Kadomoto, Tomoyuki Makino, Kouji Izumi, Atsushi Mizokami
Current status of circulating tumor cell androgen receptor splice variant-7 in metastatic castration-resistant prostate cancer
Shinichi Sakamoto
Notch signaling is essential in collecting duct epithelial cell fate determination during development and maintenance of cell type homeostasis in adult
Ming-Zhi Zhang
Socioeconomic disparities in obesity among children and future actions to fight obesity in China
Hyunjung Lim, Youfa Wang
Considerations for AR-V7 testing in clinical routine practice
Christof Bernemann, Laura-Maria Krabbe, Andres Jan Schrader
Automated quantitative assessment of oncological disease progression using deep learning
Yiftach Barash, Eyal Klang
Use of high flow nasal cannula for preoxygenation and apneic oxygenation during intubation
Jean-Damien Ricard, Baptiste Gaborieau, Juliette Bernier, Camille Le Breton, Jonathan Messika
Current assessment of the (dys)function of macrophages in endometriosis and its associated pain
Sarah Brunty, Nalini Santanam
Does diabetes mellitus play an independent prognostic role in kidney cancer?
Johannes Breyer
The role of immune checkpoint inhibitors (ICI) in the treatment of metastatic non-small cell lung carcinoma in the elderly
Johan Chan, Ravindran Kanesvaran
Clonal hematopoiesis: background player in plasma cell-free DNA variants
Kun Sun
Immunotherapy combinations transform the treatment paradigm for advanced renal cell carcinoma
Justin A. Shaya, Rana R. McKay
Taking in consideration the bystander effects of articular senescence
Jean-Marc Brondello, Yves-Marie Pers
Distal radius fracture fixation in the elderly: does better form equal better function?
Dennis K. H. Yee, Christian Fang, Frankie Leung
The cost and benefit of anti-TNF therapy from a population perspective—for what it’s worth
Joseph D. Frasca, Adam S. Cheifetz
Saline lavage and reaspiration for the diagnosis of periprosthetic joint infections
Hytham S. Salem, Joseph O. Ehiorobo, Kevin K. Mathew, Michael A. Mont


The supplement was published without any sponsorship or funding.