Improving detection combined with targeted therapy for small hepatocellular carcinoma

Surgery remains the best treatment option for cure in patients with hepatocellular carcinoma (HCC). However, the majority of patients with localised HCC are unfit for curative resection or transplantation. Currently, several modalities are available for non-surgical liver directed therapy including radiofrequency ablation (RFA), microwave ablation, cryo-ablation, ethanol injection, laser ablation, and irreversible electroporation.