Article Abstract

Editorial on “Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer”

Authors: Spencer Hart, Gopal Gupta


Renal cell carcinoma remains a common entity with approximately 65,340 new cases diagnosed in 2018. Given the insidious onset of disease, approximately 25–30% of patients will present with metastatic disease and require systemic therapy (1). Fortunately, the last two decades has seen the development of a number of targeted therapies including mammalian target of rapamycin (mTOR) inhibitors as well as tyrosine kinase inhibitors (TKIs) which are commonly used as first and second line therapies.