Article Abstract

Protecting functional β cells with a therapeutic peptide

Authors: Meghan L. Marré, Jon D. Piganelli, Eddie A. James

Abstract

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic islet β cells are targeted and destroyed by autoreactive immune cells. This loss of β cell mass leads to decreased capacity for insulin production and an eventual decline of insulin-mediated regulation of glucose levels in the blood.