Article Abstract

Acidosis and citrate: provocative interactions

Authors: Kathleen S. Hering-Smith, L. Lee Hamm


The kidneys maintain acid-base homeostasis (with the lungs controlling CO2) by reabsorbing large amounts of filtered bicarbonate (HCO3−) and excreting acid. Regulation of pH at both the cell level and organism level are important for many cellular functions and health. Both acidosis and alkalosis have both acute and long-term deleterious consequences.