Article Abstract

Be care the risk of under fit in dose-response meta-analysis when using cubic spline

Authors: Chang Xu, Chao Zhang, Joey S. W. Kwong


Dose-response meta-analysis (DMA) plays a vital role in investigating the potential causality between continuous variable and binary outcome. An increasing number of DMAs have been published during the past several years. In this letter, we aim to illustrate why some of them may at risk of under fit.