COVID-19 Column

Coronavirus disease 2019 (COVID-19): two case reports from a family cluster

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Abstract: The coronavirus disease 2019 (COVID-19) is a new infectious disease, firstly appeared in Wuhan city and has rapidly spread to 114 countries outside China, which is receiving worldwide attention. As two important means of examination, computed tomography (CT) and real-time reverse transcription polymerase chain reaction (RT-PCR) have always been controversial in the clinical diagnosis of COVID-19 pneumonia.

Fighting the novel coronavirus: the publication of the Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

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Since December 2019, there has been an outbreak of novel coronavirus (2019-nCoV) infection in China, the first case of which was reported in Wuhan, China. On January 19, 2020, the relevant experts and local government officials briefed the public on the 2019-nCoV outbreak.

Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus

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Background: The emerging infection of the 2019 novel coronavirus (2019-nCoV) in late December, 2019 in Wuhan, China, has caused an extreme health concern, with many patients having progressed to acute respiratory disease or other complications in a short period. Meanwhile, the risk factors associated with the disease progression still remain elusive.

A profiling analysis on the receptor ACE2 expression reveals the potential risk of different type of cancers vulnerable to SARS-CoV-2 infection

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Background: The new coronavirus pneumonia (NCP) is now causing a severe public health emergency. The novel coronavirus 2019 (2019-nCoV) infected individuals by binding human angiotensin converting enzyme II (ACE2) receptor. ACE2 is widely expressed in multiple organs including respiratory, cardiovascular, digestive and urinary systems in healthy individuals.

Coronavirus disease 2019 (COVID-19): the portrait of a perfect storm

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Abstract: The “novel” coronavirus disease 2019 (abbreviated “COVID-19”) is the third coronavirus outbreak emerging during the past two decades. This infectious disease, sustained by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has been recently declared a global pandemic by the World Health Organization. Despite the concerning epidemiological burden, many people, including some policymakers, are underestimating this pandemic and are remaining enigmatically inactive against a human pathology which, for a combination of reasons, can be reasonably defined as a perfect storm (i.e., the “wrong virus” at the “wrong time”).

The challenges in colorectal cancer management during COVID-19 epidemic

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Abstract: It has been over 2 months since the start of the Coronavirus disease 2019 (COVID-19) outbreak. The epidemic stage of COVID-19 has brought great challenges to the diagnosis and management of colorectal cancer (CRC) patients. Symptoms, such as fever and cough caused by cancer, and the therapeutic process (including chemotherapy and surgery) should be differentiated from some COVID-19 related characteristics.

The effect of RAS blockers on the clinical characteristics of COVID-19 patients with hypertension

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Background: Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus (designated as SARS-CoV-2) has become a pandemic worldwide. Based on the current reports, hypertension may be associated with increased risk of sever condition in hospitalized COVID-19 patients. Angiotensin-converting enzyme 2 (ACE2) was recently identified to functional receptor of SARS-CoV-2.

Chinese expert brief consensus on newborn screening of inherited metabolic disorders during the novel coronavirus infection epidemic

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Abstract: Novel coronavirus (2019-nCov) infection (COVID-19) rapidly spread across China and 25 countries in the worldwide, which infected not only adults but also children, even neonates. Each year, about 15 million newborns are delivered in China. Newborn screening (NBS) helps effectively prevent some mental retardation, premature death, and adverse outcomes in the early stage of baby

2019 novel coronavirus pneumonia with onset of dizziness: a case report

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Abstract: The 2019 novel coronavirus (2019-nCoV) epidemic continues, with the number of infections and deaths increasing. The respiratory tract is the main route of transmission of the virus, and the majority of symptoms are respiratory relative. Until now, there has been no reports concerning the nervous system onset.

Prone positioning in high-flow nasal cannula for COVID-19 patients with severe hypoxemia: a pilot study

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The COVID-19 outbreak has become a global pandemic within only a few months. COVID-19 patients complicated with severe hypoxemia usually required high-flow nasal cannula (HFNC) and mechanical ventilation. Prone positioning is a salvage therapy for refractory hypoxemia and has proven to be effective in increasing tidal volume and improving oxygenation and diaphragmatic function in patients with acute respiratory distress syndrome (ARDS) (1-3). However, all these studies were conducted in intubated patients.

Organ transplantation management in the midst of the COVID-19 outbreak: a synopsis

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On December 8, 2019, the first case of unexplained pneumonia was reported in China, in Wuhan, Hubei Province (1). By March 6, 2020, over 100,000 confirmed cases of coronavirus disease 2019 (COVID-19), and more than 3,400 deaths have been reported worldwide (data from National Health Commission of the People’s Republic of China, Official Channels of Hong Kong, Macao and Taiwan, and World Health Organization). COVID-19, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is bound to have widespread ramifications on the clinical management system, organ transplantation being a prime example.

How does Wuhan respond to 2019-nCoV outbreak when the Spring Festival comes?

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On January 16, after receiving the kits released by the central government, Hubei Provincial Centers for Disease Control and Prevention began to perform pathogen identification on the specimens obtained from Wuhan patients with viral pneumonia of unknown causes. On January 16–17, the national and provincial expert groups confirmed 4 and 17 2019-nCoV patients, respectively, based on the clinical manifestations, epidemiological histories and pathogen testing results.

COVID-19 spread, wildlife protection and the response capacity on public health crisis: empirical research of 31 provinces and cities in China

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Background: According to epidemiological investigation, many cases of coronavirus (COVID-19) pneumonia occurred in Wuhan, Hubei Province, China in December 2019. It is a respiratory infectious disease caused by human-to-human transmission and the host of COVID-19 is likely to be wild animals. On January 23, 2020, the Chinese government adopted emergency management measures to conduct closed management for Wuhan, and 31 provinces, cities and autonomous regions initiated a first-level emergency response, calling on nationals to isolate themselves at home for 14 days.

The value of CT Imaging for COVID-19 pneumonia: report of a false-negative nucleic acid test case

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In this brief letter we would like to refer to you some information about the value of CT imaging for corona virus disease 2019 (COVID-19) pneumonia in cases which have inconsistent COVID-19 nucleic acid test. A 34-year-old man had a 1-day history of fever (39.0 ℃) entered our hospital who resided in Wuhan, China (COVID-19 epicenter) but had traveled to Chengdu, China. The detection of Influenza A, B virus antigens was negative.
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Disclosure:
The series “COVID-19 Column” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding.