TY - JOUR AU - Kilcoyne, Aoife AU - Lavelle, Lisa P. AU - McCarthy, Colin J. AU - McEvoy, Sinead H. AU - Fleming, Hannah AU - Gallagher, Annika AU - Loeve, Martine AU - Tiddens, Harm AU - McKone, Edward AU - Gallagher, Charles C. AU - Dodd, Jonathan D. PY - 2016 TI - Chest CT abnormalities and quality of life: relationship in adult cystic fibrosis JF - Annals of Translational Medicine; Vol 4, No 5 (March 11, 2016): Annals of Translational Medicine Y2 - 2016 KW - N2 - Background: To evaluate the relationship between lung parenchymal abnormalities on chest CT and health-related quality of life in adult cystic fibrosis (CF). Methods: The chest CT scans of 101 consecutive CF adults (mean age 27.8±7.9, 64 males) were prospectively scored by two blinded radiologists in consensus using a modified Bhalla score. Health-related quality of life was assessed using the revised Quittner Cystic Fibrosis Questionnaire (CFQ-R). Multiple regressions were performed with each of the CFQ-R domains and all clinical and imaging findings to assess independent correlations. Results: There were 18 inpatients and 83 outpatients. For the cohort of inpatients, CT abnormalities were significantly (P Conclusions: Chest CT abnormalities are significantly associated with quality of life measures in adult CF, independent of clinical or spirometric measurements. UR - https://atm.amegroups.org/article/view/9443