TY - JOUR AU - Singer, Pierre AU - Cohen, Jonathan PY - 2015 TI - Please sir, may I have some more? The case against underfeeding JF - Annals of Translational Medicine; Vol 3, No 13 (August 15, 2015): Annals of Translational Medicine Y2 - 2015 KW - N2 - In the critically ill patient, current recommendations endorse administering nutritional support according to indirect calorimetry measurements or if not available, according to formulae, such as 25 kcal/kg ideal body weight/day or other predictive equations (1,2). However, it is universally recognized that these equations are largely inaccurate and may result in both under- or over-feeding in 40-70% of patients. Over the past few years, numerous studies have compared outcomes of patient receiving by different routes, various amounts of calories and protein (3-5). One of the most recent, by Arabi et al . (6), namely the PermiT study, compared a standard caloric regimen consisting of 70-100% of estimated caloric requirements as determined by the Penn State equation, to a permissive underfeeding regimen consisting of 40-60% of caloric requirements. UR - https://atm.amegroups.org/article/view/7169