TY - JOUR AU - Hasan, Amr AU - Mazzone, Massimiliano PY - 2015 TI - Sixty shades of oxygen—an attractive opportunity for cancer immunotherapy JF - Annals of Translational Medicine; Vol 3, No 13 (August 15, 2015): Annals of Translational Medicine Y2 - 2015 KW - N2 - Tumors evade the cytotoxic activity of T lymphocytes by secreting adenosine in the extracellular matrix which limits the infiltration and activation of cytotoxic T lymphocytes (CTLs), and this process is strongly fostered by the hypoxic microenvironment that characterizes most of the cancer types. A paper recently published in Science Translational Medicine by Hatfield et al. found that respiratory hyperoxygenation can promote tumor regression in preclinical models of cancer by re-activating the antitumoral function of CTLs and natural killer (NK) cells. UR - https://atm.amegroups.org/article/view/7081