%0 Journal Article %T Human somatic stem cell-based therapy for cartilage regeneration %A Mabuchi, Yo %A Okano, Hideyuki %J Annals of Translational Medicine %D 2015 %B 2015 %9 %! Human somatic stem cell-based therapy for cartilage regeneration %K %X Clinical investigations using human somatic tissue derived stem cells for a variety of different diseases have been performed. Neural crest-derived stem cells exhibit somatic organization, can contribute to mesenchymal stem/stromal cells (MSCs) (1) and are used for cartilage treatment, bone reconstruction and anti-inflammatory treatments for diseases. The most common cell source for cartilage treatment is MSCs (2,3). Many clinical studies have used neural crest-derived stem cells (or MSCs) from different tissues and different methodologies. These differences in the generation of somatic tissue-derived stem cells have led to variable results in clinical studies. Although stem cell properties have been poorly characterized, human trials are presently under way. %U https://atm.amegroups.org/article/view/6230 %P S17 %@ 2305-5847