%0 Journal Article %T Glucan supplementation enhances the immune response against an influenza challenge in mice %A Vetvicka, Vaclav %A Vetvickova, Jana %J Annals of Translational Medicine %D 2015 %B 2015 %9 %! Glucan supplementation enhances the immune response against an influenza challenge in mice %K %X Background: The strong immunostimulating potential of β-glucans has been well established in numerous diseases. However, the effects on viral infection were less studied. Methods: In our study, we focused on possible effects of a special combined glucan formulation on immunosuppression caused by influenza infection. Results: We found that a 2-week oral feeding with glucan mixture significantly reduced the effects of influenza infection in total mortality. Our study was focused on phagocytosis, cytokine levels, antibody response and cytotoxicity assay. Conclusions: Based on our data, we concluded that these effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load. %U https://atm.amegroups.org/article/view/5574 %V 3 %N 2 %P 22 %@ 2305-5847