TY - JOUR AU - Liu, Zeming AU - Chen, Sichao AU - Huang, Yihui AU - Hu, Di AU - Zeng, Wen AU - Wang, Min AU - Zhou, Wei AU - Chen, Danyang AU - Feng, Haifeng AU - Wei, Wei AU - Zhang, Chao AU - Zhou, Ling AU - Guo, Liang PY - 2019 TI - Synergic effects of histology subtype, tumor size, and lymph node metastasis on distant metastasis in differentiated thyroid cancer JF - Annals of Translational Medicine; Vol 7, No 20 (October 31, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Background: Detection of distant metastasis (DM) is important in differentiated thyroid cancer (DTC). This study aimed to investigate the synergic effects of histology subtype, tumor size, and lymph node metastasis (LNM) status on the occurrence of DM in DTC. Methods: We collected data of 96,788 patients with DTC. Univariate and multivariate analyses were conducted to identify the risk factors of DM. Relative excess risk of synergic effect, attributable proportion of synergic effect, and synergy index were then calculated to assess synergic effects. Further, Kaplan-Meier method using the log-rank test and receiver operating characteristic (ROC) curves were utilized. Results: Age at diagnosis (P Conclusions: Age at diagnosis, sex, race, tumor size, N stage, histology subtype, and extrathyroidal extension are risk factors for DM in DTC patients. LNM has a synergic effect with either follicular thyroid histology or larger tumor size for higher risk of DM which is important for diagnosing DM. UR - https://atm.amegroups.org/article/view/30610