%0 Journal Article %T Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males %A Che-Nordin, Nazmi %A Deng, Min %A Griffith, James F. %A Leung, Jason C. S. %A Kwok, Anthony W. L. %A Zhu, Yue-Qi %A So, Richard H. Y. %A Kwok, Timothy C. Y. %A Leung, Ping Chung %A Wáng, Yì Xiáng J. %J Annals of Translational Medicine %D 2018 %B 2018 %9 %! Prevalent osteoporotic vertebral fractures more likely involve the upper endplate than the lower endplate and even more so in males %K %X Background: While the importance of identifying osteoporotic vertebral endplate fracture (EPF) is being recognized; the pathophysiological understanding of EPF till now remain insufficient. In this population-based cross-sectional radiograph study, we aim to investigate the anatomic location characteristics of osteoporotic EPF. Methods: This study analyzed the anatomical location of osteoporotic EPFs in elderly Chinese population (age ≥65 years). The T4–L4 radiographs of 1,954 elderly Chinese men (mean: 72.3 years) and 1,953 elderly Chinese women (mean: 72.5 years) were evaluated to identify EPF, and vertebral bodies were graded according to Genant’s vertebral deformity criteria. Results: Of the 101,582 endplates analyzed, there were 505 EPFs (males: 27.7%; females: 72.3%). Excluding those with both upper endplate and lower endplate involvements, the ratio of upper EPF to lower EPF was 9.63 for males and 4.3 for females (P Conclusions: Osteoporotic EPFs more likely involve the upper endplate rather than lower endplate, with a trend for this effect to be greater in men than in women. These characteristics may help radiographic differential diagnosis for osteoporotic EPF. %U https://atm.amegroups.org/article/view/22209 %V 6 %N 22 %P 442 %@ 2305-5847