TY - JOUR AU - Jiang, Yu-Ting AU - Li, Hai-Yan AU - Cao, Xi-Peng AU - Tan, Lan PY - 2018 TI - Meta-analysis of the association between CD33 and Alzheimer’s disease JF - Annals of Translational Medicine; Vol 6, No 10 (May 26, 2018): Annals of Translational Medicine (Focus on “Translational Neurodegeneration”) Y2 - 2018 KW - N2 - Background: The cluster of differentiation 33 ( CD33 ) gene is compelling among the susceptibility genes of Alzheimer’s disease (AD) in Genome-wide association study (GWAS). Researches of the relationship between AD and polymorphism in CD33 have showed conflicting results. In order to more precisely evaluate whether CD33 variants are associated with AD, we performed the meta-analysis presented in this manuscript. Methods: We searched from three databases including PubMed, Cochrane library and EMbase for related case-control researches based on criteria of determination. A total of 18 case-control studies, containing 50,030 cases and 77,405 controls were involved in CD33 rs3865444 polymorphism. And a total of 4 case-control studies, containing 826 cases and 984 controls were involved in CD33 rs3826656 polymorphism. Results: This study demonstrated that different variants in CD33 were associated with AD (rs3865444: OR =0.94; 95% CI, 0.90–0.98, P CD33 rs3865444 polymorphism (Caucasians: OR =0.92; 95% CI, 0.90–0.94, P=0.05; Asians: OR =0.87; 95% CI, 0.65–1.17, P Conclusions: The CD33 rs3865444 polymorphism could be a protective factor in AD. Meanwhile, there was no association between the CD33 rs3826656 polymorphism and AD. Further confirmation is needed in larger and better-designed researches. UR - https://atm.amegroups.org/article/view/19409