@article{ATM19409,
author = {Yu-Ting Jiang and Hai-Yan Li and Xi-Peng Cao and Lan Tan},
title = {Meta-analysis of the association between CD33 and Alzheimer’s disease},
journal = {Annals of Translational Medicine},
volume = {6},
number = {10},
year = {2018},
keywords = {},
abstract = {Background: The cluster of differentiation 33 (CD33) gene is compelling among the susceptibility genes of Alzheimer’s disease (AD) in Genome-wide association study (GWAS). Researches of the relationship between AD and polymorphism in CD33 have showed conflicting results. In order to more precisely evaluate whether CD33 variants are associated with AD, we performed the meta-analysis presented in this manuscript.
Methods: We searched from three databases including PubMed, Cochrane library and EMbase for related case-control researches based on criteria of determination. A total of 18 case-control studies, containing 50,030 cases and 77,405 controls were involved in CD33 rs3865444 polymorphism. And a total of 4 case-control studies, containing 826 cases and 984 controls were involved in CD33 rs3826656 polymorphism.
Results: This study demonstrated that different variants in CD33 were associated with AD (rs3865444: OR =0.94; 95% CI, 0.90–0.98, P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/19409}
}