%0 Journal Article %T Association of lectin-like oxidized low density lipoprotein receptor 1 ( OLR1 ) polymorphisms with late-onset Alzheimer disease in Han Chinese %A Wang, Zuo-Teng %A Zhong, Xiao-Ling %A Tan, Meng-Shan %A Wang, Hui-Fu %A Tan, Chen-Chen %A Zhang, Wei %A Zheng, Zhan-Jie %A Kong, Ling-Li %A Tan, Lan %A Sun, Li %J Annals of Translational Medicine %D 2018 %B 2018 %9 %! Association of lectin-like oxidized low density lipoprotein receptor 1 ( OLR1 ) polymorphisms with late-onset Alzheimer disease in Han Chinese %K %X Background: Lectin-like oxidized low density lipoprotein receptor 1 (OLR1) locates within the area of chromosome 12p, which has been identified as the AD-susceptible region, and plays a role in lipid metabolism. Therefore, it has been suggested to be a good candidate gene for Alzheimer’s disease (AD). Several SNPs within OLR1 have been reported to have association with AD among Caucasians. Methods: We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese. Results: No significant association was found between the OLR1 (rs1050283, rs1050286, rs17808009) polymorphisms and LOAD, even after adjustment for gender and age and stratification for apolipoprotein E (APOE) status. Conclusions: Our study showed that the SNPs (rs1050283, rs1050286, rs17808009) located in the 3’UTR of OLR1 may not involve in the mechanism of LOAD in Han Chinese population. %U https://atm.amegroups.org/article/view/19329 %V 6 %N 10 %P 172 %@ 2305-5847