TY - JOUR AU - Agarwal, Manyoo AU - Agrawal, Sahil AU - Garg, Lohit AU - Reed, Guy L. AU - Khouzam, Rami N. AU - Ibebuogu, Uzoma N. PY - 2017 TI - Impact of smoking in patients undergoing transcatheter aortic valve replacement JF - Annals of Translational Medicine; Vol 6, No 1 (January 15, 2018): Annals of Translational Medicine (Focus on “Advances in Cardiology, Interventional Cardiology, Electrophysiology, and Structural Heart Disease: A Moving Target”) Y2 - 2017 KW - N2 - Background: The paradox that smokers have better clinical outcomes in cardiovascular diseases remains controversial. No literature exists studying impact of smoking on outcomes following transcatheter aortic valve replacement (TAVR). Methods: We performed an electronic search of the 2011–2012 National Inpatient Sample (NIS) database to identify all TAVR hospitalizations. Outcomes were measured comparing smokers to non-smokers. Results: A total of 8,345 TAVR hospitalizations were identified with 24% being smokers. Compared to non-smokers, smokers were younger (80.4±8.8 vs. 81.4±9.2 years, P<0.001), were more often men (63.6% vs. 47.8%, P<0.001), and had a higher disease burden. Despite a higher disease burden, smokers had lower post procedure stroke (2.8% vs. 3.1%), hemorrhage events (28.2% vs. 32.0%, P<0.05) and lower all cause in-hospital mortality (1.2% vs. 5.7%, adjusted odds ratio 0.21, 95% CI: 0.13–0.32, P<0.001) compared to non-smokers. Conclusions: Despite having a higher cardiovascular disease burden, smokers had better outcomes compared to non-smokers. Therefore the smoker’s paradox is applicable in the TAVR cohort. UR - https://atm.amegroups.org/article/view/17553