TY - JOUR AU - Carbone, Michele AU - Yang, Haining PY - 2017 TI - Mesothelioma: recent highlights JF - Annals of Translational Medicine; Vol 5, No 11 (June 15, 2017): Annals of Translational Medicine (Focus on “Mesothelioma”) Y2 - 2017 KW - N2 - Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma. These discoveries are: (I) the critical role of chronic inflammation in promoting mesothelioma growth, driven by the release of high mobility group box protein-1 (HMGB1) following asbestos deposition in tissues and its potential role as a biomarker to identify asbestos exposed individuals and mesothelioma patients; (II) the discovery that inherited heterozygous germline mutations of the deubiquitylase BRCA-associated protein 1 ( BAP1 ) cause a high incidence of mesothelioma in some families; and that (III) germline BAP1 mutations lower the threshold of asbestos required to cause mesothelioma in mice, evidence of gene X environment interaction. These findings together with the identification of novel serum biomarkers, including HMGB1, Fibulin-3, etc., promise to revolutionize screening and treatment of this malignancy in the coming years. UR - https://atm.amegroups.org/article/view/14824