Unresolved Basic Issues in Hepatology

Posted On 2021-05-19 17:20:42

Basic research and comparative human medical advances during the last decades and centuries have significantly improved diagnostic and treatment modalities in Hepatology. However, the evolution of this area has sparked not only scientific and clinical benefits but also controversies. The focused series “Unresolved Basic Issues in Hepatology” contains 13 reviews from leading experts from Australia, Austria, Canada, China, France, Germany, India, UK and USA highlighting current perspectives on hot and often controversial discussed topics in the field of Hepatology.

We are convinced that the different articles of this focused series are more than just a summary of what has been published as core scientific facts in a particular field. They report about areas of controversy and highlight under-examined aspects of research. In some cases, the authors have challenged fixed theories and spotlight potential future avenues in diagnosis and management of liver diseases.

Unresolved basic issues in hepatology
Ralf Weiskirchen, Wolfgang Stremmel

Review Article
Non-alcoholic fatty liver diseases: current challenges and future directions
Elke Roeb

Diagnostic management of nonalcoholic fatty liver disease: a transformational period in the development of diagnostic and predictive tools—a narrative review
Natalia Rosso, Adam M. Stephenson, Pablo J. Giraudi, Claudio Tiribelli

It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis
Amit Khurana, Nilofer Sayed, Prince Allawadhi, Ralf Weiskirchen

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention
Frank Tacke, Ralf Weiskirchen

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues
Rolf Teschke, Jack Uetrecht

Revisiting hemochromatosis: genetic vs. phenotypic manifestations
Gregory J. Anderson, Edouard Bardou-Jacquet

Therapeutic strategies in Wilson disease: pathophysiology and mode of action
Wolfgang Stremmel, Ralf Weiskirchen

Autoimmune hepatitis—is histology conclusive?
Andrea Beer, Hans Peter Dienes

Liver failure—future challenges and remaining questions
Peter Lemmer, Josef Christian Pospiech, Ali Canbay

Exosomes as therapeutic vehicles in liver diseases
Jingyi Ding, Ju Wang, Jiajia Chen

Dairy consumption and hepatocellular carcinoma risk
Bodo C. Melnik

The role of bile acids in cholestatic liver injury
Shi-Ying Cai, James L. Boyer

The neglected biliary mucus and its phosphatidylcholine content: a putative player in pathogenesis of primary cholangitis—a narrative review article
Wolfgang Stremmel, Martina Lukasova, Ralf Weiskirchen

The focused issue “Unresolved Basic Issues in Hepatology” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Ralf Weiskirchen and Wolfgang Stremmel are serving as the unpaid Guest Editors for the focused issue.