An ‘asymptomatic’ driver with COVID-19: atypical suspected myocarditis by SARS-CoV-2

Posted On 2020-05-10 05:45:16

COVID-19 has become a global hotspot (1,2). We report a case of COVID-19 with no sign of viral pneumonia but initially confirmed as myocarditis by SARS-CoV-2.

A 33-year-old-male Chinese taxi driver complained that he had contact history with a Wuhan resident on January 27, 2020. On February 5, he had chest pain, fever and muscle ache. His stool was normal. Further diagnosis and treatment were carried out in the fever clinic of our hospital on February 8. Physical examination after admission: body temperature 37.3 °C, pulse 121 times/min, breath 18 times/min, blood pressure 115/79 mmHg. ECG indicated ventricular tachycardia. On February 8, CT scan of the chest was performed: there was no exact ground-glass shadow in both lungs, a nodular calcification in the posterior segment of the upper lobe tip of the left lung near the mediastinum, and local thickening of the right pleura (Figure 1A,B). The above-mentioned chronic lesions were considered. SARS-CoV-2 nucleic acid was not detected in throat swab and EDTA anticoagulated whole blood on the same day, so viral pneumonia was not considered temporarily. On February 10, cardiac MRI was performed: the signal of T2WI in the apical region of the left ventricle was increased. After adjusting the parameters and scanning T2WI again, the signal was still increased (Figure 1C), indicating the possibility of myocardial cell edema; the signal of the corresponding segment was normal both in early gadolinium enhancement (EGE) (Figure 1D) and late gadolinium enhancement (LGE) (Figure 1E), indicating no obvious capillary leakage, myocardial necrosis or interstitial fibrosis. Left ventricular systolic function was slightly decreased (Figure 1F). Acute but atypical myocarditis was considered due to incompletely meeting Lake Louise Consensus Criteria (3). Due to subjective rejection and insufficient clinical evidence, the patient did not participate in endocardial biopsy. In order to confirm the diagnosis, urine and fecal samples were collected on the same day; no SARS-CoV-2 nucleic acid was detected in urine samples, but the two targets of SARS-CoV-2 in feces had typical S-type amplification curve (4). After consultation by the expert group, the diagnosis based on comprehensive diagnostic criteria (5) was: atypical COVID-19, myocarditis by SARS-CoV-2.

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