Vol 7, Supplement 3 (July 2019): Annals of Translational Medicine

Editorial Commentary

Immunotherapy for head and neck cancer: where are we now and where are we going?
Joshua M. Bauml, Charu Aggarwal, Roger B. Cohen
Combining immunotherapy and epidermal growth factor receptor kinase inhibitors: worth the risk?
Hira Latif, Stephen V. Liu
Current landscape of cytoreductive nephrectomy: who, when, and why?
Jiping Zeng, Alfredo Harb-De la Rosa, Juan Chipollini
New insights into cordycepin production in Cordyceps militaris and applications
Sunita Chamyuang, Amorn Owatworakit, Yoichi Honda
A novel macrophage subtype directs hematopoietic stem cell homing and retention
Marcin Wysoczynski, Joseph B. Moore IV, Shizuka Uchida
Brain metastases in EGFR-positive non-small cell lung cancer: the way to the sanctuary becomes less winding
Antonio Passaro, Letizia Gianoncelli, Valeria Stati, Filippo de Marinis
Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis
Quante Singleton, Santul Bapat, Sadanand Fulzele
Renal function after kidney surgery: “it’s tough to make predictions, especially about the future”
John M. DiBianco, Patrick T. Gomella, Mark W. Ball
Reactive astrocytes foster brain metastases via STAT3 signaling
Braden C. McFarland, Etty N. Benveniste
Depth of invasion for prognostic stratification in oral cavity cancer: do we need further validation?
Cesare Piazza, Lorenzo Bresciani, Lorenzo Giannini
Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products
Peter A. D. Wellham, Dong-Hyun Kim, Matthias Brock, Cornelia H. de Moor
Asymmetric dimethylarginine, erythropoietin resistance, and anemia in CKD
Tammy L. Sirich, Glenn M. Chertow
Editorial commentary: the multiligament injured knee: current controversies and strategies for improving outcomes
Adnan Saithna
The role of acute kidney injury duration in clinical practice
Chyi-Sheng Khor, Wei-Jie Wang
Risk reduction in kidney surgery
Martin Marszalek
Profiling changes in metabolism and the immune microenvironment in lung tumorigenesis
Di Zhang, Ana S. Leal, Fawzi Abu Rous, Karen T. Liby
Revisiting the role of lymph node dissection in renal cell carcinoma
Alice Yu, Dimitar V. Zlatev, Michael L. Blute Sr
Lack of evidence regarding bone metastases of genitourinary cancers: interventions by surgery, radiotherapy, and bone-targeted systemic therapy
Makito Miyake, Takuya Owari, Kiyohide Fujimoto
An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution
Lykourgos-Panagiotis Zalmas, Wei-Ting Lu, Nnennaya Kanu
The role of laparoscopic pancreaticoduodenectomy—how take care of patient security?
Trond A. Buanes
Pembrolizumab plus ipilimumab or pegylated interferon alfa-2b for patients with melanoma or renal cell carcinoma: take new drugs but keep the old?
Matthew Zibelman, Elizabeth R. Plimack
Non-small cell lung cancer 2 cm or less: robotic segmentectomy sets the gold standard against non-surgical therapy
Dana Ferrari-Light, Robert J. Cerfolio
State of the art in multiligament knee injuries: from diagnosis to treatment
Marcel Faraco Sobrado
Stereotactic body radiation therapy for oligometastatic renal cell carcinoma: improving outcomes in an otherwise radioresistant malignancy
Thomas H. Beckham, Brandon S. Imber, Charles B. Simone II
Smoking favours hepatocellular carcinoma
Maria Guarino, Jean-François Dufour
Predicting mortality after postcardiotomy venoarterial extracorporeal membrane oxygenation
Fausto Biancari, Angelo M. Dell’Aquila, Giovanni Mariscalco
Comment on an external validation of the 8th edition of the TNM classification for lung cancer staging in patients treated with chemoradiation
Ramón Palmero, Arturo Navarro-Martin, Ernest Nadal
Immune checkpoint inhibitors for esophageal cancer: are we moving in the right direction?
Alexander G. Raufi, Khaldoun Almhanna
TNM in non-small cell lung cancer: a staging system for all oncologists or just for surgeons?
David Ball
Improving patient selection for adjuvant therapy in high-risk renal cell carcinoma
Dylan M. Buller, Benjamin T. Ristau
Stereotactic body radiation therapy could improve disease control in oligometastatic patients with renal cell carcinoma: do we need more evidence?
Linda Agolli
Role of stereotactic body radiation therapy for the management of renal cell carcinoma: tailoring treatment in the era of the “embarrassment of riches”
Sebastiano Buti, Alessandro Leonetti, Elisabetta Lattanzi, Nunziata D’Abbiero, Melissa Bersanelli
Lobar or sublobar resections are safe procedures for management of early lung cancer
Alfonso Fiorelli, Immacolata Mauro, Gaetano Cicchitto, Aldo Prencipe, Mario Polverino, Vincenzo Giuseppe Di Crescenzo, Mario Santini
Microfracture for cartilage repair in the knee: current concepts and limitations of systematic reviews
Sang Jun Song, Cheol Hee Park
‘RNA circles of influence’ in Kaposi sarcoma
Dimitrios Tsitsipatis, Myriam Gorospe
Cellular therapy for autism spectrum disorder: a step forward to the optimal treatments
Dario Siniscalco, Nicola Antonucci
Reconsider minimally invasive surgery for early cervical cancer
Yi Zhang, Shuguang Chen
Key players of neuroendocrine differentiation in prostate cancer
Matteo Santoni, Gaetano Aurilio, Alessandro Maccioni, Franco Nolè, Nicola Battelli
Urologic and interventional radiology treatment of renal cell carcinomas—similarities and differences
Diep Nguyen, Eric vanSonnenberg, Paul Kang, Peter R. Mueller
Is the adipose-derived mesenchymal stem cell therapy effective for treatment of knee osteoarthritis?
Ilaria Roato, Riccardo Ferracini
Antioxidant therapy in chronic pancreatitis—promises and pitfalls
Kwang Hyun Ko, Jeong Min An, Mi Seo Son, Jae Bock Chung, Ki Baik Hahm
VCAM-1+ macrophages usher hematopoietic stem and progenitor cell to vascular niche “hotspots”
Yahui Grace Chiu, Moh’d Khushman
Vitamin C’s essential role in DNA and histone demethylation and a preclinical rationale for its therapeutic high-dose potential in renal cell carcinoma
Ching-Hui Huang, Chia-Chu Chang
Immunotherapy for mucosal melanoma
Kelley Sherling, Brittany Case
Salvage procedures for chronic gastric leaks after sleeve gastrectomy: the role of laparoscopic Roux-en-Y fistulo-jejunostomy
Panagiotis Lainas, Naim Schoucair, Carmelisa Dammaro, Ibrahim Dagher
Comment for “nomogram establishment for surgery-related complications in partial nephrectomy”
Katsumi Shigemura, Shian-Ying Sung, Kuan-Cho Chen, Masato Fujisawa
Looking beyond cancer for cabozantinib-induced cardiotoxicity: evidence of absence or absence of evidence?
Eugenia Y. Lee, Andrew T. Yan
A 7.0–7.7% value for glycated haemoglobin is better than a <7% value as an appropriate target for patient-centered drug treatment of type 2 diabetes mellitus
José Pedro L. Nunes, Joseph P. DeMarco
Behaviorally associated changes in neuroconnectivity following autologous umbilical cord blood infusion in young children with autism spectrum disorder
Richard E. Frye
Arterial erectile dysfunction is an early sign of vascular damage: the importance for the prevention of cardiovascular health
Sandro La Vignera, Rosita A. Condorelli, Rossella Cannarella, Filippo Giacone, Aldo E. Calogero
The effect of centralization of abdominal aortic aneurysm repair procedures on perioperative outcomes
Kosmas I. Paraskevas
Spread through air spaces-positive T1 lung adenocarcinoma: is lobectomy associated with better outcomes than sublobar resection?
Kathleen Weiss, Matthew M. Rochefort
Extended follow-up on KEYNOTE-024 suggests significant survival benefit for pembrolizumab in patients with PD-L1 ≥50%, but unanswered questions remain
Jose M. Pacheco, Dexiang Gao, D. Ross Camidge
Progress in interferon-gamma release assay development and applications: an unfolding story of translational research
Ajit Lalvani, Hilary S. Whitworth
Testing two (of several) intravenous iron dosing strategies in hemodialysis
Margaret K. Yu, Glenn M. Chertow
New promising circulating RNA biomarkers for early diagnosis of lung adenocarcinoma
Francisco J. Enguita
Fluoxetine in stroke (FOCUS) trial—reasons to be cheerful about antidepressants in stroke?
Terence J. Quinn
Cardiovascular and renal protection with sodium-glucose cotransporter type 2 inhibitors: new paradigm in type 2 diabetes management…and potentially beyond
André J. Scheen
Serum neurofilament light chain rate of change in Alzheimer’s disease: potentials applications and notes of caution
Federico Massa, Riccardo Meli, Silvia Morbelli, Flavio Nobili, Matteo Pardini
Nephrometry score correlated with tumor proliferative activity inT1 clear cell renal cell carcinoma—the tiger in the tall grasses versus the cat in plain sight
Ziting Wang, Ho Yee Tiong
New insights in predictive determinants of the tumor immune microenvironment for immune checkpoint inhibition: a never ending story?
Markus Eckstein, Shilpa Gupta
Post-operative surveillance in kidney cancer
Ofer Gofrit, Marina Orevi
Another one in the chamber: cabozantinib for patients with metastatic non clear cell renal cell carcinoma
Vincenzo Di Nunno, Francesco Massari, Veronica Mollica, Alessia Cimadamore, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi
Personalized medicine in breast cancer: a step forward
Alejandro Martin Sanchez, Gianluca Franceschini, Daniela Terribile, Sabatino D’Archi, Lorenzo Scardina, Riccardo Masetti
Renal cell carcinoma response to checkpoint inhibitors may be predicted by senescence activity in tumor microenvironment
Javier González, Gaetano Ciancio
Pembrolizumab monotherapy for PD-L1 ≥50% non-small cell lung cancer, undisputed first choice?
Willemijn S. M. E. Theelen, Paul Baas
A critical evaluation of the role of robotic-assisted surgery in complex pediatric urology cases
Patricio Gargollo
Prevention of cognitive decline in old age—varying effects of interventions in different populations
Chengxuan Qiu, Gunilla Johansson, Feiqi Zhu, Miia Kivipelto, Bengt Winblad
Predicting biological behaviour of newly diagnosed renal masses: a possible role of cell proliferation biomarkers?
Riccardo Mastroianni, Aldo Brassetti, Manuela Costantini, Giuseppe Simone
Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery
Richard W. Olsen, A. Kerstin Lindemeyer, Martin Wallner, Xiaorun Li, Kevin W. Huynh, Z. Hong Zhou
Role of cytoreductive nephrectomy in metastatic renal cell carcinoma patients with tumor thrombus: does it change with development of systemic therapy?
Fumitaka Koga
Do hypofraction and large breast size reciprocally fit in breast cancer radiotherapy?
Pierfrancesco Franco, Sara Bartoncini, Stefania Martini, Giuseppe Carlo Iorio, Umberto Ricardi
Long-term survival following thoracoscopic versus open lobectomy for stage I non-small cell lung cancer
Hussein Elkhayat, Diego Gonzalez Rivas
Turning stem cells homing potential into cancer specific drug delivery machines
Nedime Serakinci, Huseyin Cagsin
Is nodal disease burden relevant in patients with renal cell carcinoma and lymph node invasion?
Francisco Rodriguez-Covarrubias
68Ga-dotatoc vs. 18F-FDG vs. radiolabelled PSMA PET/CT in renal cancer patients
Laura Evangelista, Fabio Zattoni, Pierpaolo Alongi
Parallels between antibody-mediated rejection and ischemic kidney injury with respect to B cell activation
Stuart J. Knechtle, Jean Kwun
FOCUS trial: results, potentialities and limits
Luca Saba, Antonella Balestrieri, Alessandra Serra, Raimondo Garau, Carola Politi, Pierleone Lucatelli, Alessandro Murgia, Jasjit S. Suri, Lorenzo Mannelli
Novel therapeutic approaches for pancreatic cancer by combined targeting of RAF→MEK→ERK signaling and autophagy survival response
Faustino Mollinedo, Consuelo Gajate
Outcome of safety and efficacy of allogeneic mesenchymal stromal cell derived from umbilical cord for the treatment of osteoarthritis in a randomized blinded placebo-controlled trial
Kiran Shah, Huseyin Sumer
Breakthroughs and challenges in the management of tropomyosin receptor kinase fusion-positive tumors
Hirva Mamdani, Shadia I. Jalal
Pluripotential stem cells as replacement therapy in degenerative diseases of the eye
Colin J. Barnstable
Should we perform peripheral laser iridotomy in primary angle closure suspects: implications of the ZAP trial?
Vivek Gupta, Tanuj Dada
Better screened than sorry!—an informed panel of inherited DNA repair gene variants for prostate cancer screening and prognostication
Giulia Fracassi, Francesca Lorenzin, Francesca Demichelis


The supplement was published without any sponsorship or funding.