Vol 4, No 24 (December 2016): Annals of Translational Medicine

Original Article

Effects of curcumin on Helicobacter pylori infection
Vaclav Vetvicka, Jana Vetvickova, Rafael Fernandez-Botran
Inertia based microfluidic capture and characterisation of circulating tumour cells for the diagnosis of lung cancer
Dimple Y. Chudasama, Daria V. Freydina, Maxim B. Freidin, Maria Leung, Angeles Montero Fernandez, Alexandra Rice, Andrew G. Nicholson, Emmanouil Karteris, Vladimir Anikin, Eric Lim

Case Report

Gastric metastases from gynaecologic tumors: case reports and review of the literature
Angelo Zullo, Giuseppina Balsamo, Roberto Lorenzetti, Adriana Romiti, Vincenzo De Francesco, Cesare Hassan, Raffaele Manta


Does relief of outflow tract obstruction in patients with hypertrophic cardiomyopathy improve long-term survival? Implications for lowering the threshold for surgical myectomy and alcohol septal ablation
Srihari S. Naidu, Julio A. Panza, David Spielvogel, Ramin Malekan, Joshua Goldberg, Wilbert S. Aronow
Human behaviour, benign or malevolent: understanding the human psyche, performing therapy, based on affective mentalization and Matte-Blanco’s bi-logic
Fionn Murtagh, Giuseppe Iurato
Using epigenomic data to inform genome-wide association studies of bone mineral density
John A. Morris
Alleviation of gram-negative bacterial lung inflammation by targeting HECTD2
Rick Kapur, John W. Semple
Virus vs. virus: adenovirus vectored vaccine to defeat respiratory syncytial virus
Alessandra Vitelli, Alfredo Nicosia
Circulating microRNA biomarkers for cardiovascular risk prediction: are we approaching clinical application?
Maurice W. J. de Ronde, Yigal M. Pinto, Sara-Joan Pinto-Sietsma
Clinical utility of novel biomarkers in acute myocardial infarction
Thomas Stiermaier, Holger Thiele, Ingo Eitel
From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients
Rami A. Namas, Yoram Vodovotz
Genomic predictor of complete response after chemoradiotherapy in rectal cancer
Gyoung Tae Noh, Nam Kyu Kim
The evolving approach to sedation in ventilated patients: a real world perspective
Annachiara Marra, Pratik P. Pandharipande
Fatty acid-binding proteins as diagnostic and prognostic markers in pneumonia
Raphae S. Barlas, Phyo K. Myint
Ventilation in acute respiratory distress syndrome: importance of low-tidal volume
Saraschandra Vallabhajosyula, Vrinda Trivedi, Ognjen Gajic
Defensin-chemokine heteromeric complexes derived from heterocellular activation—a possible target to inhibit CCL5 in cardiovascular settings
Osamu Baba, Yongjian Liu, Gwendalyn J Randolph
Is pulmonary artery pressure a trigger of adverse outcome in mitral regurgitation?
Iside Scarfò, Giovanni La Canna
An effective DNA vaccine platform for Middle East respiratory syndrome coronavirus
Adam S Cockrel, Ralph S Baric
Prospects to translate the biology of IL-33 and ST2 during organ transplantation into therapeutics to treat graft-versus-host disease
Ian C. Scott, Kirsty F. Houslay, E. Suzanne Cohen
Attempting to define and refine vasopressin use in septic shock: the VANISH trial
Aviral Roy, Richard Phillip Dellinger
Early detection of myocardial infarction—microRNAs right at the time?
Nicolle Kränkel, Stefan Blankenberg, Tanja Zeller
Treatment of non-small cell lung cancer ≤2 cm in size: less may not be more
Siobain M. Horan, Sai Yendamuri
Are we ready to introduce T790M plasma analysis in the follow up of patients with NSCLC under treatment with EGFR-TKI?
Estibaliz Alegre, Débora Martínez, Mónica Macías, Álvaro González
Do insights from mice imply that combined Th2 and Th17 therapies would benefit select severe asthma patients?
Matthew E. Poynter
Every other day bathing with chlorhexidine gluconate: what is the evidence?
Jackson S. Musuuza, Nasia Safdar
Advances in anterior cruciate ligament reconstruction techniques
Roberto Seijas, Andrea Sallent, Oscar Ares
Targeting colorectal cancer (stem-like) cells using LGR5 directed antibody drug conjugates
Daniela Hirsch, Thomas Ried
SAMP-ening down sepsis
Alison Coady, Victor Nizet
Inhibition of receptor activator of nuclear factor kappa-B ligand pathway for the management of aggressive osteosarcoma
Ioannis Panagiotidis, Dimitrios Christoulas, Evangelos Terpos
Cardiac fibrosis and miR-433
Jae Gyun Oh, Roger J. Hajjar, Woo Jin Park
The “gut microbiota” hypothesis in primary sclerosing cholangitis
Valerio Pontecorvi, Marco Carbone, Pietro Invernizzi
Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy
Thomas. Scambler, Conor Feeley, Michael F. McDermott
Volatile anesthetics for lung protection: a bridge between operating rooms and intensive care units?
Giovanni Landoni, Omar Saleh, Elena Scarparo, Alberto Zangrillo
Ultrasound: a novel translational tool to study diaphragmatic dysfunction in critical illness
Philippe G. Jorens, Tom Schepens
In search for the Holy Grail of cough guidelines
Anne B. Chang
Can multispectral optoacoustic tomography replace sentinel lymph biopsy in melanoma?
Stanley P. L. Leong, Sri-Rajasekhar Kothapalli, Sanjiv Sam Gambhir


Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets
David W. Clark, Komaraiah Palle
Cancer stem cells don’t waste their time cleaning—low proteasome activity, a marker for cancer stem cell function
Kristiaan J. Lenos, Louis Vermeulen
Simian immunodeficiency virus confounds T follicular helper T cells and the germinal centre
Tom N. Lea-Henry, Simon H. Jiang
Focusing the management of rectal cancer
Rachel Dbeis, Neil J. Smart, Ian R. Daniels
P53 mutations and cancer: a tight linkage
Francesco Perri, Salvatore Pisconti, Giuseppina Della Vittoria Scarpati
Targeted nanoparticles for tumour radiotherapy enhancement—the long dawn of a golden era?
Elisabetta Gargioni, Florian Schulz, Annette Raabe, Susanne Burdak-Rothkamm, Thorsten Rieckmann, Kai Rothkamm
Potential biomarkers for radiosensitivity in head and neck cancers
Sherly Pardo-Reoyo, J. L. Roig-Lopez, Eddy S. Yang
Anticoagulant independent mechanical heart valves: viable now or still a distant holy grail
Aurelio Chaux, Richard J. Gray, Jonathan C. Stupka, Michael R. Emken, Lawrence N. Scotten, Rolland Siegel
Improved outcomes with surgery vs. medical therapy in non-thymomatous myesthenia gravis: a perspective on the results of a randomized trial
Olugbenga T. Okusanya, Nick Hess, Neil Christie, James D. Luketich, Inderpal S. Sarkaria
Scoring systems for the characterization of sepsis and associated outcomes
Natalie McLymont, Guy W. Glover


HECTD2 one step closer to understand susceptibility for acute respiratory disease syndrome?
Alexander P. J. Vlaar
Going into BATTLE: umbrella and basket clinical trials to accelerate the study of biomarker-based therapies
Sawsan Rashdan, David E. Gerber
Tranexamic acid and total hip arthroplasty: optimizing the administration method
Jean-Edern Ollivier, Stéphane Van Driessche, Fabien Billuart, Julien Beldame, Jean Matsoukis
Optimum treatment for chronic obstructive pulmonary disease exacerbation prevention
Pradeep Karur, Dave Singh
Is the revision of a primary TKA really as easy and safe as the revision of a primary UKA?
Kevin Staats, Christian Merle, Tom Schmidt-Braekling, Friedrich Boettner, Reinhard Windhager, Wenzel Waldstein
Finding ways to solve or prevent aminoglycoside-induced ototoxicity?
Jin Li, Connie W. Woo
RANKL inhibitors for osteosarcoma treatment: hope and caution
Eva M. Trinidad, Eva González-Suárez
Is it time for SABR to overtake surgery as the treatment of choice for stage I non-small cell lung cancer?
Susannah M. Love, Gillian Hardman, Ruchir Mashar, Rajesh D. Shah
Idolizing the clearance of Amyloid-β by microglia
Nienke Marlies Van Loon, Noam Zelcer
The role of circulating microRNAs in acute coronary syndromes: ready for prime time?
Gert Klug, Bernhard Metzler
Uncovering the influence of the FGFR1 pathway on glioblastoma radiosensitivity
Karen K. Sayal, Geoffrey S. Higgins, Ester M. Hammond
MicroRNA-499-5p: a therapeutic target in the context of cardiovascular disease
Menno Hoekstra
Reconstruction of the medial patellofemoral ligament reconstruction for patients with recurrent patellar dislocation: review of surgical techniques and tips to achieve successful reconstruction
Giacomo Placella, Valerio Pace, Paul Foster
Pulmonary hypertension: a long-term risk stratifier in primary mitral regurgitation
Mi-Jeong Kim, Hae Ok Jung
Should the patella be resurfaced in distal femoral replacement after distal femoral resection?
Chun Hoi Yan
What the blood knows: interrogating circulating tumor DNA to predict progression of minimal residual disease in early breast cancer
Melanie Majure, Aaron C. Logan
Polytherapy as first-line in status epilepticus: should we change our practice? “Time is brain”!
Ashalatha Radhakrishnan
Targeting NF2-Hippo/Yap signaling pathway for cardioprotection after ischemia/reperfusion injury
Masum M. Mia, Ayshwarya L. Chelakkot-Govindalayathil, Manvendra K. Singh
The downside of human natural killer cell diversity in viral infection revealed by mass cytometry
Mir Munir A. Rahim
Acquired resistance mechanisms to immunotherapy
Teresa Amaral, Claus Garbe
Therapeutic potential of targeting microRNAs to regulate cardiac fibrosis: miR-433 a new fibrotic player
Jenny Y. Y. Ooi, Bianca C. Bernardo, Julie R. McMullen
Preclinical randomized controlled multicenter trials (pRCT) in stroke research: a new and valid approach to improve translation?
Walter Balduini, Silvia Carloni, Mauro Cimino
Combining traditional medicine and modern chemistry to fight malaria
Christiaan van Ooij
Micro-RNAs as promising biomarkers in cardiac diseases
Mariama Akodad, Mathias Mericskay, François Roubille
Anatomic placement of the acetabulum improves the survival rate in patients with Crowe type-II dysplasia undergoing total hip arthroplasty
Ruyin Hu, Bo Li, Xiaobin Tian
Endothelial progenitor cells and cardiovascular risk: does ageing trump all other factors?
Amaryllis H. Van Craenenbroeck, Emeline M. Van Craenenbroeck
Myeloid-derived suppressor cell, arginase-1, IL-17 and cl-CD95L: an explosive cocktail in lupus?
Robin J. Flynn, Patrick Legembre
Chlorhexidine bathing every other day still does the trick, but it may come at a cost
Susana Chávez-Moreno, Adrián Camacho-Ortiz


1. The series “Big-data Clinical Trial Column” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding.

2. The series “Meet the Professor” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding.