Vol 9, No 22 (November 30, 2021): Annals of Translational Medicine

Editorial

Regional delivery of immunosuppression for transplantation of vascularized composite allografts: opportunities near and far
Jeffrey L. Platt, Marilia Cascalho, Christina L. Kaufman
Annals of Translational Medicine
 2021;
9
(22)
:1635
Editorial: reducing blood loss in liver transplantation—the impact of surgical technique
Marcos V. Perini, Vijayaragavan Muralidharan
Annals of Translational Medicine
 2021;
9
(22)
:1636
Reducing readmissions in patients with cirrhosis: the time to act is now
Arpan Patel, Jejo D. Koola, Michael E. Matheny
Annals of Translational Medicine
 2021;
9
(22)
:1637

Original Article

Do simultaneous mandibular advancement and temporomandibular joint prosthesis impact the upper airway in TMJ ankylosis patients?
Hui Li, Dongmei He, Qianyang Xie, Ahmed Abdelrehem, Dong Huang, Chi Yang
Annals of Translational Medicine
 2021;
9
(22)
:1638
Determinants of survival in advanced non-small cell lung cancer patients treated with anti-PD-1/PD-L1 therapy
Wael Abdullah Sultan Ali, Pan Hui, Yuxiang Ma, Yuehan Wu, Yang Zhang, Yukun Chen, Shaodong Hong, Yunpeng Yang, Yan Huang, Yuanyuan Zhao, Wenfeng Fang, Hongyun Zhao, Li Zhang
Annals of Translational Medicine
 2021;
9
(22)
:1639
Body mass index is not associated with early onset cataract in the 45 and Up cohort study
Jiaqing Zhang, Wei Wang, Guangyao Yang, Jason Ha, Xuhua Tan, Xianwen Shang, Zhuoting Zhu, Xiaotong Han, Zhenzhen Liu, Lei Zhang, Mingguang He, Lixia Luo
Annals of Translational Medicine
 2021;
9
(22)
:1640
In vitro assessment of an engineered tBID-based safety switch system in human T lymphocytes
Jiamiao Lu, Patrick Collins, Ki Jeong Lee, Chi-Ming Li, Songli Wang
Annals of Translational Medicine
 2021;
9
(22)
:1641
Syngeneic bone marrow transplantation in combination with PI3K inhibitor reversed hyperglycemia in later-stage streptozotocin-induced diabetes
Shiyun Zhang, Qianqian Dai, Bin Zhang, Siyang Liu, Ying Wang, Yixue Zhang, Dongyue Chen, Ningning Zong, Hongwei Wang, Jingjing Ding, Qian Gao, Yanting Wen
Annals of Translational Medicine
 2021;
9
(22)
:1642
Inflammatory signals and network connections implicate cell-mediated immunity in chronic venous insufficiency
Lena Vodovotz, Ruben Zamora, Derek A. Barclay, Yoram Vodovotz, Jinling Yin, Julie Bitner, John Florida, Efthymios D. Avgerinos, Ulka Sachdev
Annals of Translational Medicine
 2021;
9
(22)
:1643
Liposomal honokiol inhibits glioblastoma growth through regulating macrophage polarization
Shenglan Li, Long Li, Jinyi Chen, Yaqiong Fan, Ce Wang, Yuan Du, Caixia Guo, Feng Chen, Wenbin Li
Annals of Translational Medicine
 2021;
9
(22)
:1644
The application of transbronchial cryobiopsy in interstitial lung disease: a prospective, multicenter, real-world study
Xiaobo Chen, Jing Li, Fengming Luo, Feng Tao, Xiaoju Zhang, Youru Wu, Ping Xu, Mingyao Ke, Fa Long, Laiyu Liu, Liping Lv, Huai Liao, Ye Gu, Zhiguang Liu, Xiaoming Tan, Shuliang Guo, Yi Hu, Huaping Yang, Yong Zhou, Hongmei Zhou, Yongshun Ye, Difei Chen, Shiyue Li
Annals of Translational Medicine
 2021;
9
(22)
:1645
A bibliometric analysis of infectious diseases in patients with liver transplantation in the last decade
Han Zhong, Chun-Yan Liu, You-Qin Dai, Cheng Zhu, Ke-Jia Le, Xiao-Yun Pang, Yu-Jie Li, Zhi-Chun Gu, Yue-Tian Yu
Annals of Translational Medicine
 2021;
9
(22)
:1646
Ventilation in patients with stage IIIB or above lung cancer
Haiqin Zhang, Jinhua Ni, Qijian Cheng
Annals of Translational Medicine
 2021;
9
(22)
:1647
Characterization of microRNAs in spent culture medium associated with human embryo quality and development
Shanshan Wang, Lei Chen, Yingchun Zhu, Weihua Jiang
Annals of Translational Medicine
 2021;
9
(22)
:1648
Reciprocal induction of hepatitis C virus replication and stimulation of hepatic profibrogenic cytokine release and cellular viability by YKL-40
Du Cheng, Chengliang Zhu, Fei Liao, Liang Zhao, Lei Shen, Wenyang Jiang
Annals of Translational Medicine
 2021;
9
(22)
:1649
The clinical prognostic value of PD-L1 after concurrent chemoradiotherapy in Chinese nasopharyngeal carcinoma patients
Guoxian Long, Xiaoyu Li, Lin Yang, Jing Zhao, Xiang Lu, Heng Wang, Jia Song, Qi Mei, Guangyuan Hu
Annals of Translational Medicine
 2021;
9
(22)
:1650
Effects of preoperative pulmonary function on short-term outcomes and overall survival after video-assisted thoracic surgery lobectomy
Yihe Wu, Yuwei Zhou, Shenhu Gao, Chengli Du, Linpeng Yao, Rong Yang
Annals of Translational Medicine
 2021;
9
(22)
:1651
MicroRNA-376b-3p targets RGS1 mRNA to inhibit proliferation, metastasis, and apoptosis in osteosarcoma
Lei Zhang, Meng Yao, Weikang Ma, Yongqing Jiang, Wenbo Wang
Annals of Translational Medicine
 2021;
9
(22)
:1652
Adipose-derived mesenchymal stem cells (AD-MSCs) in the treatment for psoriasis: results of a single-arm pilot trial
Danni Yao, Shuyan Ye, Ziyang He, Yu Huang, Jingwen Deng, Zehuai Wen, Xinsheng Chen, Hongyi Li, Qin Han, Hao Deng, Robert Chunhua Zhao, Chuanjian Lu
Annals of Translational Medicine
 2021;
9
(22)
:1653
Gender-specific nomogram models to predict the prognosis of male and female lung adenocarcinoma patients: a population-based analysis
Hui Wen, Xuefeng Lin, Daqiang Sun
Annals of Translational Medicine
 2021;
9
(22)
:1654
ATF3: a novel biomarker for the diagnosis of acute kidney injury after cardiac surgery
Xiaoyun Wu, Feng Qiu, Xianglan Jin, Jian Zhou, Wangfu Zang
Annals of Translational Medicine
 2021;
9
(22)
:1655
Exchange proteins directly activated by cyclic adenosine monophosphate inhibitor reverses mechanical allodynia via the modification of astrocytes activity in the spinal cord
Qing She, Junjie Chen, Chaochao Zhong, Saisai Huang, Cui’e Lu, Yibin Qin
Annals of Translational Medicine
 2021;
9
(22)
:1656
AEBP1 as a potential immune-related prognostic biomarker in glioblastoma: a bioinformatic analyses
Mingjian Liu, Yuyu Yu, Ziqian Zhang, Zhenghong Chen, Bin Chen, Yijun Cheng, Yongxu Wei, Jia Li, Hanbing Shang
Annals of Translational Medicine
 2021;
9
(22)
:1657
Effect of iron overload on endothelial cell calcification and its mechanism
Lili Zhao, Ning Yang, Yanqiu Song, Hailong Si, Qin Qin, Zhigang Guo
Annals of Translational Medicine
 2021;
9
(22)
:1658
Characteristics of genomic mutations and signaling pathway alterations in thymic epithelial tumors
Weilin Yang, Sai Chen, Xinxin Cheng, Bo Xu, Huilan Zeng, Jianyong Zou, Chunhua Su, Zhenguang Chen
Annals of Translational Medicine
 2021;
9
(22)
:1659
The role of TGF-β pathway alterations in immune regulation as a potential pan-cancer biomarker in immunotherapy
Yan Liang, Wei Li, Bing Qian, Jie Ming, Zhengyi Zhao, Zhengqing Yan, Xiaochen Zhao, Shiqing Chen, Yongmei Yin
Annals of Translational Medicine
 2021;
9
(22)
:1660
Comprehensive analysis of DNA damage repair deficiency in 10,284 pan-cancer study
Yanni Xiao, Di Lu, Mingxing Lei, Wenzhuan Xie, Yaoxu Chen, Yating Zheng, Chunli Wang, Jing Zhao, Zhen Zhu, Xiaochen Zhao, Mengli Huang, Youen Lin, Zhongjun Li, Li Yang
Annals of Translational Medicine
 2021;
9
(22)
:1661
Artificial intelligence-assisted detection and classification of colorectal polyps under colonoscopy: a systematic review and meta-analysis
Aling Wang, Jiahao Mo, Cailing Zhong, Shaohua Wu, Sufen Wei, Binqi Tu, Chang Liu, Daman Chen, Qing Xu, Mengyi Cai, Zhuoyao Li, Wenting Xie, Miao Xie, Motohiko Kato, Xujie Xi, Beiping Zhang
Annals of Translational Medicine
 2021;
9
(22)
:1662
Application of a novel magnetic anchoring and traction technique in thoracoscopic esophagectomy: a swine experiment
Wenwen Chen, Yunhao Li, Rongkai Qian, Meiling Jiang, Lu Lv, Siyu Ren, Aihua Shi, Xiaopeng Yan, Junke Fu, Haohua Wang, Feng Ma, Yi Lv, Yong Zhang
Annals of Translational Medicine
 2021;
9
(22)
:1663
Development and validation of an early predictive nomogram for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
Long Zhao, Tao Chen, Hao-Ji Yan, Chang Liu, Yi Cao, Yi Zhang, Ping Lin, Xiao-Ping Tang, Liang-Xue Zhou
Annals of Translational Medicine
 2021;
9
(22)
:1664
Radiomic signatures based on multiparametric MR images for predicting Ki-67 index expression in medulloblastoma
Lili Zhou, Hong Peng, Qiang Ji, Bo Li, Lexin Pan, Feng Chen, Zishan Jiao, Yali Wang, Mengqian Huang, Gaifen Liu, Yaou Liu, Wenbin Li
Annals of Translational Medicine
 2021;
9
(22)
:1665
Risk factors for delirium after coronary artery bypass grafting in elderly patients
Jian Li, Dongmei Meng, Chao Chang, Bo Fu, Chang Xie, Zhenhua Wu, Lianqun Wang
Annals of Translational Medicine
 2021;
9
(22)
:1666
N-glycosylation of somatostatin receptor type 2 protects rats from acute pancreatitis
Ming Huang, Min-Min Chen, Dong Han, Wei Chen, Feng Xu
Annals of Translational Medicine
 2021;
9
(22)
:1667
Autophagy-related long non-coding RNA signature for potential prognostic biomarkers of patients with cervical cancer: a study based on public databases
Qian Feng, Jingyuan Wang, Nan Cui, Xian Liu, Haiyan Wang
Annals of Translational Medicine
 2021;
9
(22)
:1668
NOTCH2NLA silencing inhibits ovarian carcinoma progression and oncogenic activity in vivo and in vitro
Wendi Guo, Zhen Sun, Nannan Zhao, Yiwen Zhou, Jie Ren, Lingling Huang, Yi Ping
Annals of Translational Medicine
 2021;
9
(22)
:1669
Trimethylamine-N-oxide-stimulated hepatocyte-derived exosomes promote inflammation and endothelial dysfunction through nuclear factor-kappa B signaling
Xiang Liu, Yijia Shao, Jiazichao Tu, Jiapan Sun, Lifu Li, Jun Tao, Jimei Chen
Annals of Translational Medicine
 2021;
9
(22)
:1670
Knockdown of phosphoinositide-dependent kinase 1 (PDK1) inhibits fibrosis and inflammation in lipopolysaccharide-induced acute lung injury rat model by attenuating NF-κB/p65 pathway activation
Keke Yang, Boqian Li, Jinghua Chen
Annals of Translational Medicine
 2021;
9
(22)
:1671
Phenotype and molecular characterizations of a family with dentinogenesis imperfecta shields type II with a novel DSPP mutation
Qin Du, Li Cao, Yi Liu, Chunyan Pang, Si Wu, Liwei Zheng, Wei Jiang, Xiaoxue Na, Jing Yu, Shasha Wang, Xianjun Zhu, Jiyun Yang
Annals of Translational Medicine
 2021;
9
(22)
:1672
The role of autoantibody detection in the diagnosis and staging of lung cancer
Yun Wang, Yang Jiao, Cui-Min Ding, Wu-Zhuang Sun
Annals of Translational Medicine
 2021;
9
(22)
:1673
A randomized controlled trial of oral nutritional supplementation versus standard diet following McKeown minimally invasive esophagectomy in patients with esophageal malignancy: a pilot study
Hounai Xie, Xiankai Chen, Lei Xu, Ruixiang Zhang, Xiaozheng Kang, Xiufeng Wei, Yafan Yang, Yin Li
Annals of Translational Medicine
 2021;
9
(22)
:1674
Applying the pathogen-targeted next-generation sequencing method to pathogen identification in cerebrospinal fluid
Daiquan Gao, Yongqiang Hu, Xuebin Jiang, Hao Pu, Zhendong Guo, Yunzhou Zhang
Annals of Translational Medicine
 2021;
9
(22)
:1675
Botrychium schaffneri Underw. extract acts via DIABLO to induce apoptosis and inhibit proliferation of non-small cell lung carcinoma in vitro and in vivo
Yu-Jia Liu, Yi-Wen Zhang, Shui-Lian Zheng, Xiao-Chun Zheng, Hai-Ying Ding, Wen-Xiu Xin, Jiao Sun, Li Li, Ping Huang
Annals of Translational Medicine
 2021;
9
(22)
:1676
Value of breast MRI omics features and clinical characteristics in Breast Imaging Reporting and Data System (BI-RADS) category 4 breast lesions: an analysis of radiomics-based diagnosis
Qian Cui, Liang Sun, Yu Zhang, Zimu Zhao, Shuo Li, Yajie Liu, Hongwei Ge, Dongxue Qin, Yiping Zhao
Annals of Translational Medicine
 2021;
9
(22)
:1677
Identification of novel hub genes associated with lymph node metastasis of head and neck squamous cell carcinoma by completive bioinformatics analysis
Honglue Lu, Liang Li, Dongnan Sun, Yuansheng Duan, Kai Yue, Yansheng Wu, Xudong Wang
Annals of Translational Medicine
 2021;
9
(22)
:1678
Long noncoding TMPO antisense RNA 1 promotes hepatocellular carcinoma proliferation and epithelial-mesenchymal transition by targeting the microRNA-126-3p/LRP6/β-catenin axis
Weifeng Huang, Qingsong Chen, Jiangweng Dai, Yuke Zhang, Yan Yi, Xufu Wei
Annals of Translational Medicine
 2021;
9
(22)
:1679
The clinical value of hematological neutrophil and monocyte parameters in the diagnosis and identification of sepsis
Wenping Zhang, Zhongming Zhang, Shiyao Pan, Jin Li, Yanmei Yang, Huan Qi, Jiabin Xie, Jiuxin Qu
Annals of Translational Medicine
 2021;
9
(22)
:1680
Correlation of elastic characteristics of breast lesions with the expression of Smad2/3
Meng-Ke Zhang, Shi-Yu Li, Shao-Wei Xue, Gang Liu, Zhi-Li Wang
Annals of Translational Medicine
 2021;
9
(22)
:1681
Propranolol inhibits stemness of hemangioma through Jagged1
Xiaorong Ma, Kaiyang Lv, Liming Wu, Tianxiang Ouyang
Annals of Translational Medicine
 2021;
9
(22)
:1682
Netrin-1 promotes retinoblastoma-associated angiogenesis
Xiaosheng Yang, Hui Sun, Tianchi Tang, Wenchuan Zhang, Yi Li
Annals of Translational Medicine
 2021;
9
(22)
:1683
Development and validation of a nomogram prediction model for early mortality in patients with primary malignant cardiac tumors
Shaojun Wang, Hui Jing, Zhiyong Yang
Annals of Translational Medicine
 2021;
9
(22)
:1684
RNA sequencing reveals the circular RNA expression profiles of the infrapatellar fat pad/synovium unit
Tao Jiang, Yimin Lu, Zehua Chen, Xiaodong Lin, Jiayuan Zhang, Jiaxin Shan, Chao Lu, Chuanxi Zhao, Xuemeng Xu, Wengang Liu
Annals of Translational Medicine
 2021;
9
(22)
:1685
IFI30 as a prognostic biomarker and correlation with immune infiltrates in glioma
Wei Jiang, Feifei Zheng, Taotao Yao, Fang Gong, Wenjie Zheng, Ninghua Yao
Annals of Translational Medicine
 2021;
9
(22)
:1686
Short-term analysis of uniport video-assisted thoracoscopic surgery via the subxiphoid approach without chest tube drainage for anterior mediastinal tumors: a comparative retrospective study
Min Cao, Qing Wang, Hang Yin, Yujie Fu, Xiaojing Zhao
Annals of Translational Medicine
 2021;
9
(22)
:1687
Comparison of popliteal artery aneurysm outcomes after open repair and endovascular repair: reducing post-operative type II endoleak and sac enlargement
Jinting Ge, Tiehao Wang, Jichun Zhao, Ding Yuan, Bin Huang, Yi Yang
Annals of Translational Medicine
 2021;
9
(22)
:1688
NUSAP1 promotes the metastasis of breast cancer cells via the AMPK/PPARγ signaling pathway
Juanjuan Qiu, Li Xu, Xiaohong Zeng, Zhenru Wu, Yu Wang, Yao Wang, Jiqiao Yang, Hao Wu, Yanyan Xie, Faqing Liang, Qing Lv, Zhenggui Du
Annals of Translational Medicine
 2021;
9
(22)
:1689
Prediction models and nomograms of 3-year risk of chronic kidney disease in China: a study from the Shanghai Suburban Adult Cohort and Biobank (2016–2020)
Yuting Yu, Qi Zhao, Yonggen Jiang, Na Wang, Xing Liu, Yun Qiu, Junjie Zhu, Xin Tong, Shuheng Cui, Genming Zhao
Annals of Translational Medicine
 2021;
9
(22)
:1690
Efficacy and safety of neostigmine for neuromuscular blockade reversal in patients under general anesthesia: a systematic review and meta-analysis
Wentao Ji, Xiaoting Zhang, Jia Liu, Guolin Sun, Xiandong Wang, Lulong Bo, Xiaoming Deng
Annals of Translational Medicine
 2021;
9
(22)
:1691
Identification of ubiquitinated substrate proteins and their gene expression patterns in lung adenocarcinoma
Ran Xu, Tong Lu, Jiaying Zhao, Qi Li, Jun Wang, Bo Peng, Jian Liu, Pengfei Zhang, Lidong Qu, Xiaoyan Chang, Lingqi Yao, Linyou Zhang
Annals of Translational Medicine
 2021;
9
(22)
:1692
Y-box binding protein 1 regulates liver lipid metabolism by regulating the Wnt/β-catenin signaling pathway
Zhenzeng Ma, Yu Zhu, Qizhi Wang, Min Deng, Jianchao Wang, Dapeng Li, Lin Gu, Rui Zhao, Shanjun Yan
Annals of Translational Medicine
 2021;
9
(22)
:1693
Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway
Jie Liu, Wei Ma, Cheng-Hao Zang, Guo-Dong Wang, Si-Jia Zhang, Hong-Jie Wu, Ke-Wei Zhu, Xiang-Lin Xiang, Chun-Yan Li, Kuang-Pin Liu, Jian-Hui Guo, Li-Yan Li
Annals of Translational Medicine
 2021;
9
(22)
:1694
GSK-3β activates NF-κB to aggravate caerulein-induced early acute pancreatitis in mice
Xiaoying Fu, Xi Zhong, Xudong Chen, Dujiang Yang, Zongguang Zhou, Yong Liu
Annals of Translational Medicine
 2021;
9
(22)
:1695
Growth hormone secretagogue receptor deficiency promotes lung cancer growth by affecting the Th17/Treg balance
Liang Wu, Dongliang Li, Linlin Qin, Qingliang Wang, Yuichi Saito, Ricciardi Sara, Jiang Fan
Annals of Translational Medicine
 2021;
9
(22)
:1696
Integrated analysis of immune infiltration in esophageal carcinoma as prognostic biomarkers
Hang Yin, Xiaoyuan Wang, Nannan Jin, Xiaodong Ling, Xue Leng, Yu Wang, Keru Ma, Xiangyu Jiang, Jinhong Zhu, Jianqun Ma
Annals of Translational Medicine
 2021;
9
(22)
:1697
Role of the Alarmin S100A9 protein in inducing Achilles tendinopathy in rats
Bin-An Zhao, Jun Li, Chao Xue, Jie Li, Heng-An Ge, Biao Cheng, Qi-Hang Su
Annals of Translational Medicine
 2021;
9
(22)
:1698
Effect of cigarette smoke extract on mitochondrial division in mouse quadriceps femoris cells
Zhidan Tan, Siqi Li, Su Zhu, Xiaoxuan Yao, Jing Li, Xinglin Gao, Shifang Yang
Annals of Translational Medicine
 2021;
9
(22)
:1699
A multicenter single-arm trial of sintilimab in combination with chemotherapy for neoadjuvant treatment of resectable esophageal cancer (SIN-ICE study)
Hongtao Duan, Tianhu Wang, Zhilin Luo, Xiaoyuan Wang, Honggang Liu, Liping Tong, Xiaoping Dong, Yong Zhang, Michele Valmasoni, Biniam Kidane, Khaldoun Almhanna, Ory Wiesel, Sainan Pang, Jianqun Ma, Xiaolong Yan
Annals of Translational Medicine
 2021;
9
(22)
:1700
Andrographolide inhibits non-small cell lung cancer cell proliferation through the activation of the mitochondrial apoptosis pathway and by reprogramming host glucose metabolism
Zhao Chen, Wei-Jian Tang, Yu-Han Zhou, Zhou-Miao Chen, Kai Liu
Annals of Translational Medicine
 2021;
9
(22)
:1701
Development of a novel miR-3648-related gene signature as a prognostic biomarker in esophageal adenocarcinoma
Donglei Zhang, Hang Yin, Thomas L. Bauer, Michael P. Rogers, Jeffrey B. Velotta, Clinton T. Morgan, Weijia Du, Ping Xu, Xiaozhe Qian
Annals of Translational Medicine
 2021;
9
(22)
:1702

Review Article

The prospect of immunotherapy combined with chemotherapy in patients with advanced non-small cell lung cancer: a narrative review
Xiangu Ning, Yang Yu, Songjun Shao, Rong Deng, Jie Yu, Xuming Wang, Xueke She, Depei Huang, Xudong Shen, Weiming Duan, Jin Duan, Hushan Zhang
Annals of Translational Medicine
 2021;
9
(22)
:1703
A narrative review of research progress on FoxM1 in breast cancer carcinogenesis and therapeutics
Yan-Ling Zhang, Yan Ma, You-Qin Zeng, Yan Liu, En-Ping He, Yi-Tong Liu, Feng-Ling Qiao, Rong Yu, Ying-Shuang Wang, Xin-Yu Wu, Ping Leng
Annals of Translational Medicine
 2021;
9
(22)
:1704
A narrative review of liver regeneration—from models to molecular basis
Wei Huang, Ning Han, Lingyao Du, Ming Wang, Liyu Chen, Hong Tang
Annals of Translational Medicine
 2021;
9
(22)
:1705

Case Report

Resection of a giant sternal chondrosarcoma and chest wall reconstruction: a case report
Dahai Liu, Zizong Wang, Tong Qiu, Feng Hou, Yi Qin, Yi Shen, Bingxue Song
Annals of Translational Medicine
 2021;
9
(22)
:1706

Editorial Commentary

Non-intubated robotic-assisted thoracic surgery for tracheal/airway resection and reconstruction safe: editorial commentary
Donatas Zalepugas, Philipp Schnorr, Joachim Schmidt, Benedetta Bedetti
Annals of Translational Medicine
 2021;
9
(22)
:1707
Perspectives and horizons of non-intubated robotic-assisted tracheal surgery
Isabella B. Metelmann, Matthias Steinert, Sebastian Kraemer
Annals of Translational Medicine
 2021;
9
(22)
:1708