Original Article

Glucan supplementation enhances the immune response against an influenza challenge in mice

Vaclav Vetvicka, Jana Vetvickova


Background: The strong immunostimulating potential of β-glucans has been well established in numerous diseases. However, the effects on viral infection were less studied.
Methods: In our study, we focused on possible effects of a special combined glucan formulation on immunosuppression caused by influenza infection.
Results: We found that a 2-week oral feeding with glucan mixture significantly reduced the effects of influenza infection in total mortality. Our study was focused on phagocytosis, cytokine levels, antibody response and cytotoxicity assay.
Conclusions: Based on our data, we concluded that these effects are caused by stimulation of both cellular and humoral immune reaction resulting in lower viral load.

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