Comprehensive characterization of hepatitis B virus-associated multifocal hepatocellular carcinoma using a multi-omics strategy

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide (1). Although numerous studies have examined the molecular mechanisms involved in hepatocarcinogenesis, powerful diagnostic and/ or prognostic factors as well as an efficient therapeutic target for HCC have yet to be developed.