Glycosylation of natriuretic peptides in obese heart failure: mechanistic insights

Natriuretic peptides (NPs) are cardiac derived hormones that are secreted in response to increased wall stress, stretching of the myocardium, volume overload, and angiotensin II stimulation. The principal circulating NPs, atrial and B-type NP (ANP and BNP respectively) are released as precursor molecules (proANP and proBNP) which are processed to active components ANP and BNP, and inactive amino-terminal fragments NT-proANP and NT-proBNP (1).