Neuropathic pain models and outcome measures: a dual translational challenge

Robert D. E. Sewell


The phenomenon of pain may be neuropathic in nature and it invariably stems from disease or injury affecting the somatosensory system (1,2). Neuropathic pain is usually a chronic condition and is a significant cause of morbidity. It has a pronounced impact on wellbeing as well as patient quality of life and of those patients presenting with pain, up to a quarter of them suffer neuropathic pain (3,4). It involves symptoms of an abnormally unpleasant sensation (dysesthesia), allodynia typified by a painful sensation to a normally innocuous stimulus and hyperalgesia characterized by an exaggerated pain perception to a normally noxious stimulus (5).