Advances in resistant hypertension

David A. Calhoun


Resistant hypertension (RHTN) has historically been defined as high blood pressure (BP) that remains uncontrolled despite use of 3 or more antihypertensive agents from different classes, including ideally, a diuretic. In 2008, the first American Heart Association Scientific Statement on RHTN included a new category of “controlled RHTN” as high BP controlled on 4 or more antihypertensive agents (1).