Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax

Yoshinori Marunaka, Rie Marunaka, Hongxin Sun, Toshiro Yamamoto, Narisato Kanamura, Akiyuki Taruno


The body fluid (extracellular fluid: ECF) volume is mainly regulated by Na+ uptake (absorption) in the colon (1-3) and Na+ reabsorption in the kidney (4-7), and plays various important roles in the body functions such as regulation of blood pressure.