Hajime Isomoto, MD

Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Professor of Medicine, Tottori University, Japan

I have been a professor of Department of Multidisciplinary Internal Medicine, Tottori University since 2015. I have licenses of MD (1990) and of PhD (1999). In 2003, I was a postdoctorial fellow, Gastrointestinal Unit, Massachusetts General Hospital, and in 2004, had been a postdoctorial fellow, Basic Research Center for Gastrointestinal Diseases, Mayo Clinic for 2 years. Recently, I have been tackled with endoscopic therapy including endoscopic submucosal dissection (ESD) for gastrointestinal tumors. In cases of ESD for extended superficial esophageal tumors, post-ESD esophageal stricture occurs frequently. More recently, we have succeeded inthe prevention of luminal stricture following esophageal ESD usinginnovative transplantation of autologous tissue-engineered epithelial cell sheets in humans.In the research field, we have been studying gastrointestinal carcinogenesis in association with chronic inflammatory processes in particular via microRNA and DNA methylation. These epigenetic mechanisms in carcinogenesis pave the way for new therapeutic strategy.