Hajime Isomoto, MD

Nagasaki University Hospital, Department of
Gastroenterology and Hepatology, 1-7-1 Sakamoto, Nagasaki 8528102, Japan.

I have been an associate professor of Department of Endoscopy, Nagasaki University Hospital in the southwest part of Japan since 2009. I have licenses of MD (1990) and of PhD (1999). In 2003, I was a postdoctorial fellow, Gastrointestinal Unit, Massachusetts General Hospital, and in 2004, had been a postdoctorial fellow, Basic Research Center for Gastrointestinal Diseases, Mayo Clinic for 2 years. Recently, I have been tackled with endoscopic therapy including endoscopic submucosal dissection (ESD) for gastrointestinal tumors. In cases of ESD for extended superficial esophageal tumors, post-ESD esophageal stricture occurs frequently. More recently, we have succeeded inthe prevention of luminal stricture following esophageal ESD usinginnovative transplantation of autologous tissue-engineered epithelial cell sheets in humans.In the research field, we have been studying gastrointestinal carcinogenesis in association with chronic inflammatory processes in particular via microRNA and DNA methylation. These epigenetic mechanisms in carcinogenesis pave the way for new therapeutic strategy.