TY - JOUR AU - Basu, Atreyee AU - Seth, Shashi AU - Chauhan, Ashok K. AU - Bansal, Nupur AU - Arora, Kanchan AU - Mahaur, Anuradha PY - 2016 TI - Comparative study of tumor markers in patients with colorectal carcinoma before and after chemotherapy JF - Annals of Translational Medicine; Vol 4, No 4 (February 29, 2016): Annals of Translational Medicine Y2 - 2016 KW - N2 - Background: Colorectal carcinoma (CRC), the second leading cause of cancer-related deaths in US, has a rising time-trend in India. Tumour markers in CRC are extensively researched, and there’s still debate on their diagnostic and prognostic values. Methods: In this hospital-based longitudinal study in north India, 51 male diagnosed CRC cases (pre-chemotherapy) were contrasted against 50 age and sex matched controls. Nine biomarkers: carcinoembryonic antigen (CEA), prolactin (PRL), alfa feto protein (AFP), total human chorionic gonadotropin (hCG), cancer antigen-125 (CA-125), serum testosterone, prostate specific antigen (PSA) and ferritin were measured by direct chemiluminescence technique. Further, follow-up was done on 47 cases after treatment with six cycles of 5-flurouracil (5-FU) and oxaliplatin. Results: Mean serum CEA (case: 5.94±8.27 ng/mL, control: 2.5±0.79 ng/mL, P Conclusions: The present study strongly indicates the role of CEA, PRL, AFP, CA-125 and testosterone as important biomarkers in male CRC patients from north India. Further, AFP, CA-125 and CEA may be used to assess the effectiveness of chemotherapy in such patients. UR - https://atm.amegroups.org/article/view/9241