TY - JOUR AU - He, Lidong AU - Rockwood, Alan L. AU - Agarwal, Archana M. AU - Anderson, Lissa C. AU - Weisbrod, Chad R. AU - Hendrickson, Christopher L. AU - Marshall, Alan G. PY - 2020 TI - Top-down proteomics—a near-future technique for clinical diagnosis? JF - Annals of Translational Medicine; Vol 8, No 4 (February 29, 2020): Annals of Translational Medicine (Focus on "Intrauterine Adhesion") Y2 - 2020 KW - N2 - We thank Dr. Laszlo Prokai, Dr. Jae-Seok Kim, and Dr. Hyun Sik Kim for their insightful editorial commentaries on our recent publication “ Diagnosis of hemoglobinopathy and β-thalassemia by 21 Tesla Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry of hemoglobin from blood ” (1-3). As described by the editorial authors, 21 Tesla Fourier transform ion cyclotron resonance mass spectrometry (21 T FT-ICR MS) and top-down MS/MS set a new benchmark for precision diagnosis of hemoglobinopathies and thalassemia with fast sample preparation (dilute and infuse) and data acquisition (3 min). UR - https://atm.amegroups.org/article/view/34388