@article{ATM33235,
author = {Fangqi Liu and Jiang Zhao and Cong Li and Yuchen Wu and Wang Song and Tianan Guo and Shiqing Chen and Sanjun Cai and Dan Huang and Ye Xu},
title = {The unique prognostic characteristics of tumor deposits in colorectal cancer patients},
journal = {Annals of Translational Medicine},
volume = {7},
number = {23},
year = {2019},
keywords = {},
abstract = {Background: Both AJCC 7th and 8th TNM systems have included tumor deposits (TDs) in nodal staging when lymph nodes metastases (LNMs) are negative in colorectal cancer (CRC). However, the prognostic role of TDs has not been determined in the presence of positive LNMs.
Methods: Two independent large-scale cohorts of CRC patients from the Surveillance Epidemiology and End Results (SEER) database (n=69,178) [2010–2013] and Fudan University Shanghai Cancer Center (FUSCC) (n=3,137) [2010–2014] were retrospectively analyzed. Kaplan-Meier method was used to estimate survival curves and univariate and multivariate analyses were performed by Cox proportional hazard model.
Results: TDs were observed in 12.3% (n=8,480) and 14.8% (n=463) of patients in the SEER and FUSCC cohorts, respectively. Multivariate analysis suggested TDs were an independent adverse prognostic factors for overall survival (OS) (P},
issn = {2305-5847}, url = {https://atm.amegroups.org/article/view/33235}
}