TY  - JOUR
AU  - Huang, Xiaosheng
AU  - Xu, Yunping
AU  - Chen, Wenchieh
AU  - Zhu, Tianhui
AU  - He, Liumei
AU  - Wang, Songxing
AU  - Peng, Shiming
AU  - Mei, Shaoyi
AU  - Wang, Yan
AU  - Zhao, Jun
PY  - 2019
TI  - The genetic contribution of  HLA-E*01:03  and  HLA-E*01:03-G*01:01  to Posner-Schlossman syndrome in southern Chinese
JF  - Annals of Translational Medicine; Vol 7, No 23 (December 15, 2019): Annals of Translational Medicine
Y2  - 2019
KW  - 
N2  -  Background:  The polymorphisms of classical  HLA-Ia  and  HLA-II  loci have been associated with Posner- Schlossman syndrome (PSS) in the southern Chinese population. However, the associations of non-classical  HLA-Ib  (e.g.,  HLA-E  and  HLA-G ) loci with PSS have not been reported for in the southern Chinese population. This study aimed to evaluate the associations of the  HLA-E  and  HLA-G  loci with PSS in a southern Chinese Han population group.   Methods:   Ninety-seven unrelated patients with PSS and 90 ethnically matched control subjects were recruited from the Shenzhen Eye Hospital in China. The full-length sequences of  HLA-E  and  HLA-G  genes were amplified by long-range high-fidelity PCR, and the third exon of the  HLA-E  gene and the coding region of the  HLA-G  gene were sequenced.   Results:   The allele frequency of  HLA-E*01:03  in patients with PSS was significantly higher than that in the control group (P=0.017, corrected P=0.034, OR =1.66). The genotype frequencies of  HLA-E*01:01/01:03  and  HLA-E*01:03/01:03  in the PSS group were significantly higher than that in the control group (P=0.027, OR =2.62; P=0.011, OR =3.05; respectively). There were no significant differences in the frequency of  HLA-G  alleles and genotypes between the two groups (all P>0.05). The haplotype frequency of  HLA- E*01:03-G*01:01  in the PSS group was significantly higher than that in the control group (P=0.019, OR =1.63), although this association did not survive the Bonferroni correction (corrected P=0.13).    Conclusions:   This study proved for the first time that  HLA-E*01:03  and  HLA-E*01:03-G*01:01  might be risk factors for PSS.
UR  - https://atm.amegroups.org/article/view/32707