TY - JOUR AU - Wu, Yue AU - Jiang, Jie-Hui AU - Chen, Li AU - Lu, Jia-Ying AU - Ge, Jing-Jie AU - Liu, Feng-Tao AU - Yu, Jin-Tai AU - Lin, Wei AU - Zuo, Chuan-Tao AU - Wang, Jian PY - 2019 TI - Use of radiomic features and support vector machine to distinguish Parkinson’s disease cases from normal controls JF - Annals of Translational Medicine; Vol 7, No 23 (December 15, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Background: Parkinson’s disease (PD) is an irreversible neurodegenerative disease. The diagnosis of PD based on neuroimaging is usually with low-level or deep learning features, which results in difficulties in achieving precision classification or interpreting the clinical significance. Herein, we aimed to extract high- order features by using radiomics approach and achieve acceptable diagnosis accuracy in PD. Methods: In this retrospective multicohort study, we collected 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images and clinical scale [the Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn & Yahr scale (H&Y)] from two cohorts. One cohort from Huashan Hospital had 91 normal controls (NC) and 91 PD patients (UPDRS: 22.7±11.7, H&Y: 1.8±0.8), and the other cohort from Wuxi 904 Hospital had 26 NC and 22 PD patients (UPDRS: 20.9±11.6, H&Y: 1.7±0.9). The Huashan cohort was used as the training and test sets by 5-fold cross-validation and the Wuxi cohort was used as another separate test set. After identifying regions of interests (ROIs) based on the atlas-based method, radiomic features were extracted and selected by using autocorrelation and fisher score algorithm. A support vector machine (SVM) was trained to classify PD and NC based on selected radiomic features. In the comparative experiment, we compared our method with the traditional voxel values method. To guarantee the robustness, above processes were repeated in 500 times. Results: Twenty-six brain ROIs were identified. Six thousand one hundred and ten radiomic features were extracted in total. Among them 30 features were remained after feature selection. The accuracies of the proposed method achieved 90.97%±4.66% and 88.08%±5.27% in Huashan and Wuxi test sets, respectively. Conclusions: This study showed that radiomic features and SVM could be used to distinguish between PD and NC based on 18F-FDG PET images. UR - https://atm.amegroups.org/article/view/32699