TY - JOUR AU - Zhang, Yue AU - Qian, Huizhu AU - Xu, Jing AU - Gao, Wen PY - 2019 TI - ADAR, the carcinogenesis mechanisms of ADAR and related clinical applications JF - Annals of Translational Medicine; Vol 7, No 22 (November 29, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Adenosine deaminases acting on RNA (ADARs) catalyze the conversion of adenosine (A) to inosine (I) in double-stranded RNA, which can change the codons after transcription. Abnormal ADAR editing is present in a variety of cancers. However, the study of the biological effects of ADARs in cancer is not very deep. Here, we review current important ADAR-mediated editing events, related carcinogenic mechanisms and applications in clinical medicine. Further exploration in ADARs can provide a new direction for cancer treatment. UR - https://atm.amegroups.org/article/view/31844