TY - JOUR AU - Focosi, Daniele AU - Tuccori, Marco AU - Maggi, Fabrizio PY - 2019 TI - Checkpoint inhibitors and progressive multifocal leukoencephalopathy: friends of foes? JF - Annals of Translational Medicine; Vol 7, Supplement 8 (December 31, 2019): Annals of Translational Medicine Y2 - 2019 KW - N2 - Progressive multifocal leukoencephalopathy (PML) has evolved in the last decade from a disorder of acquired immune deficiency syndrome (AIDS) patients into a rare but fatal complication of several life-saving therapeutics (ranging from rituximab in non-Hodgkin lymphomas to natalizumab in multiple sclerosis). PML is linked to opportunistic reactivation of the latent human JC polyomavirus (JCV), which leads to emergence of neurotropic strains causing brain demyelination. UR - https://atm.amegroups.org/article/view/31812