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Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson’s disease

  
@article{ATM31677,
	author = {Congcong Sun and Zhenxiang Zhao and Wenfei Yu and Mingshu Mo and Chengyuan Song and Youfeng Si and Yiming Liu},
	title = {Abnormal subpopulations of peripheral blood lymphocytes are involved in Parkinson’s disease},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {22},
	year = {2019},
	keywords = {},
	abstract = {Background: Abnormal immune responses are involved in the development of Parkinson’s disease (PD), and also affect peripheral blood lymphocytes. The profile of lymphocyte subsets in peripheral blood and whether it is relevant to the clinical features of PD patients remains controversial.
Methods: To explore the role of peripheral blood lymphocytes (NK cells, B cells, CD3+ T cells, CD3+CD4+ T cells and CD3+CD8+ T cells) in the development of PD, a case-control study including 127 patients and 148 healthy controls was conducted, and peripheral blood lymphocyte subpopulations of participants were analysed by a FACSCalibur flow cytometer.
Results: PD patients had a significantly higher percentage of NK cells and a lower percentage of CD3+ T cells and CD3+CD4+ T cells than controls [16.4% (12.3%) vs. 12.6% (6.2%), 63.7% (14.2%) vs. 69.0% (6.6%), 33.1% (13.1%) vs. 38.9% (7.6%), P},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/31677}
}