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Predictive factors and prognostic value of pathologic complete response of ipsilateral supraclavicular lymph nodes in breast cancer after neoadjuvant chemotherapy

  
@article{ATM31559,
	author = {Jiujun Zhu and Dechuang Jiao and Xuhui Guo and Jianghua Qiao and Youzhao Ma and Jingyang Zhang and Hui Chen and Hui Xiao and Yue Yang and Zhenduo Lu and Zhenzhen Liu},
	title = {Predictive factors and prognostic value of pathologic complete response of ipsilateral supraclavicular lymph nodes in breast cancer after neoadjuvant chemotherapy},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {22},
	year = {2019},
	keywords = {},
	abstract = {Background: Breast cancer with ipsilateral supraclavicular lymph node metastasis is one of the indicators of poor prognosis. Patients who attain pathologic complete response in breast and axillary sites have improved survival and are highest in aggressive HR–HER2– and HER2-positive tumor subtypes. However, there is no study on the related factors and prognostic value of supraclavicular pathologic complete response in breast cancer after neoadjuvant chemotherapy. The aim of our work was to investigate the factors and prognostic significance of pathologic complete response of ipsilateral supraclavicular lymph node metastasis in breast cancer after neoadjuvant chemotherapy. 
Methods: A total of 214 patients with breast cancer who had primary ISLN metastasis, receiving NAC and subsequent ISLN dissection, were retrospectively and consecutively reviewed. Univariate and multivariate analyses were performed using χ2 test and the logistic regression model, and the prognosis was analyzed by Kaplan-Meier curve. 
Results: All patients included were women who were 26–74 years old. The rate of supraclavicular pathologic complete response (pCR) was 53.7%. Multivariate analysis showed that the expression of Ki67, breast pCR, and axillary pCR were independent predictors of supraclavicular pCR (P},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/31559}
}