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Effect of Candida albicans bronchial colonization on hospital-acquired bacterial pneumonia in patients with systemic lupus erythematosus

  
@article{ATM31543,
	author = {Yuetian Yu and Jia Li and Suli Wang and Yuan Gao and Hui Shen and Liangjing Lu},
	title = {Effect of  Candida albicans  bronchial colonization on hospital-acquired bacterial pneumonia in patients with systemic lupus erythematosus},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {22},
	year = {2019},
	keywords = {},
	abstract = {Background: To investigate the effect of Candida albicans airway colonization on hospital-acquired bacterial pneumonia (HABP) in patients with systemic lupus erythematosus (SLE).
Methods: SLE patients with HAP were enrolled in this retrospective cohort study from January 2015 to December 2018. According to the culture results of respiratory tract secretions and antifungal treatment, patients were divided into non-C. albicans colonization group (NCG), C. albicans colonization with antifungal treatment group (CTG) and C. albicans colonization without antifungal treatment group (CNTG). Twenty- eight days of all-cause mortality after the onset of HABP of each group was assessed, total duration of antibiotic treatment, changes of inflammatory cytokines and markers of immune status were documented. 
Results: A total of 269 SLE patients with HABP were finally included in the study. Among them, 69.1% (186/269) were found C. albicans airway colonization, and 36.1% (97/269) received antifungal treatment. No difference of 28 days of all-cause mortality after HABP onset was found among the three groups (10.8% vs. 13.4% vs. 15.7%, P>0.05). Duration of antibiotic treatment of HABP due to Acinetobacter baumannii was shorter in CTG (11.21±2.45 days) than that in CNTG (12.89±3.87 days) as well as HABP due to Pseudomonas aeruginosa (10.57±2.66 vs. 12.56±3.04 days), (P},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/31543}
}