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Decreased expression of EFCC1 and its prognostic value in lung adenocarcinoma

  
@article{ATM31484,
	author = {Liang Xia and Yunke Zhu and Chuanfen Zhang and Senyi Deng and Yulan Deng and Zhenyu Yang and Jiandong Mei and Lunxu Liu},
	title = {Decreased expression of EFCC1 and its prognostic value in lung adenocarcinoma},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {22},
	year = {2019},
	keywords = {},
	abstract = {Background: So far, there is a lack of reliable prognostic biomarkers for lung adenocarcinoma (ADC). Initially, we found that EF-hand and coiled-coil domain containing 1 (EFCC1) was a novel gene which was downregulated consistently with the progression of lung ADC in The Cancer Genome Atlas (TCGA) data through bioinformatics analysis. In this study, we aimed to evaluate the prognostic significance of EFCC1 in lung ADC in both TCGA data and clinical samples.
Methods: Firstly, the expression level and prognostic significance of EFCC1 in lung ADC were investigated in TCGA data. Then, the expression level of EFCC1 was validated by qPCR, Western blot, and immunohistochemistry (IHC) in five clinical lung ADC and matched adjacent non-tumor tissues. Finally, the association of EFCC1 expression with clinicopathological characteristics and overall survival (OS) in lung ADC patients was further evaluated in 130 clinical lung ADC samples with tissue microarray (TMA). 
Results: In TCGA data, we found that decreased mRNA expression (P},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/31484}
}