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Vortioxetine versus sertraline in metabolic control, distress and depression in Mexican patients with type 2 diabetes

	author = {Carlos Alfonso Tovilla-Zárate and Antonia Pérez-Mandujano and Iris Rubí Ramírez-González and Ana Fresan and Samuel Suarez-Mendez and Esteban Martínez-Villaseñor and Ester Rodríguez-Sánchez and Mario Villar-Soto and María Lilia López-Narváez and Thelma Beatriz González-Castro and Jorge L. Ble-Castillo and Isela Esther Juárez-Rojop},
	title = {Vortioxetine versus sertraline in metabolic control, distress and depression in Mexican patients with type 2 diabetes},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {22},
	year = {2019},
	keywords = {},
	abstract = {Background: Depression in patients with type 2 diabetes (T2D) is often undiagnosed and remains untreated, leading to poor therapy adherence and ill health-related outcomes. We evaluated the effect of vortioxetine versus sertraline in the treatment of depression, distress and metabolic control in subjects with T2D and depression. 
Methods: Participants were selected from the Clinic for Diabetes, diagnosed with depression when the score was ≥14 in the Hamilton Depression Rating Scale, and verified by a psychiatrist in agreement with the DSM-5 instrument (Diagnostic and Statistical Manual of Mental Disorders, fifth edition). The criteria for recruitment also included glycosylated hemoglobin ≥7.5%, 18 to 60 years of age, and written informed consent. Pharmacological treatment for depression was assigned randomly: vortioxetine (10 mg/day) or sertraline (75 mg/day) for 8 weeks. Biochemical parameters, anthropometric measures and depression symptoms were evaluated after antidepressant treatment. This was a randomized singled-blind study. 
Results: Subjects that met the inclusion criteria were 50, of which only 21 patients with T2D and depression finished the treatment. Vortioxetine and sertraline showed partial remission of depression. Vortioxetine showed a major effect size in glycosylated hemoglobin and a moderate effect size on weight loss, fasting plasma glucose (FPG), cholesterol and triacylglycerol levels. On the other hand, patients treated with sertraline presented a slight increase in body weight, body mass index (BMI), and in all biochemical markers. 
Conclusions: Vortioxetine may ameliorate depressive symptoms and metabolic control in patients with T2D and depression. Trial registration number: NCT03978286.},
	issn = {2305-5847},	url = {}