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Circulating tumor cell-based or tissue biopsy-based AR-V7 detection: which provides the greatest clinical utility?

  
@article{ATM30777,
	author = {Arpit Rao and Emmanuel S. Antonarakis},
	title = {Circulating tumor cell-based or tissue biopsy-based AR-V7  detection: which provides the greatest clinical utility?},
	journal = {Annals of Translational Medicine},
	volume = {0},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {Metastatic castration-resistant prostate cancer (mCRPC) is a condition characterized by cancer progression in the setting of low serum testosterone levels (1,2), and represents the lethal phase of the disease. Biologically, the development of castration-resistance occurs through a multitude of primarily androgen receptor (AR)-dependent mechanisms such as AR amplification, AR mutation, AR splice variant expression, and increase in synthesis of intratumoral and adrenal androgens through CYP17 and other pathways (3,4).},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/30777}
}