%0 Journal Article %T Resistance of the stable—towards more precise prediction of response to immune checkpoint blockade in microsatellite-unstable cancer patients %A Kloor, Matthias %J Annals of Translational Medicine %D 2019 %B 2019 %9 %! Resistance of the stable—towards more precise prediction of response to immune checkpoint blockade in microsatellite-unstable cancer patients %K %X The introduction of immune checkpoint blockade into the clinical practice has marked a milestone for treating patients with advanced microsatellite-unstable (MSI) cancer (1,2). MSI tumors are evolving with a deficiency of the DNA mismatch repair (MMR) system and therefore accumulate numerous somatic mutations during every cell division, resulting in a very high mutational load in the manifest tumors (3,4). %U https://atm.amegroups.org/article/view/30449 %V 7 %N 21 %P 603 %@ 2305-5847