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Resistance of the stable—towards more precise prediction of response to immune checkpoint blockade in microsatellite-unstable cancer patients

  
@article{ATM30449,
	author = {Matthias Kloor},
	title = {Resistance of the stable—towards more precise prediction of response to immune checkpoint blockade in microsatellite-unstable cancer patients},
	journal = {Annals of Translational Medicine},
	volume = {7},
	number = {21},
	year = {2019},
	keywords = {},
	abstract = {The introduction of immune checkpoint blockade into the clinical practice has marked a milestone for treating patients with advanced microsatellite-unstable (MSI) cancer (1,2). MSI tumors are evolving with a deficiency of the DNA mismatch repair (MMR) system and therefore accumulate numerous somatic mutations during every cell division, resulting in a very high mutational load in the manifest tumors (3,4).},
	issn = {2305-5847},	url = {http://atm.amegroups.com/article/view/30449}
}